35 research outputs found
Nucleobindin-1 modulates extracellular matrix remodeling by promoting intra-Golgi trafficking of matrix metalloproteinase 2
- Publication venue
- Ludwig-Maximilians-Universität München
- Publication date
- 01/01/2020
- Field of study
Matrix metalloproteases (MMPs) play a crucial role in tissue homeostasis. Profuse literature has studied their roles in cell migration and tissue invasion during cancer metastasis, as well as in inflammatory processes. Although the literature covering MMPs function is abundant, the intracellular trafficking of these proteins remains poorly understood. The aim of the present work was to identify the molecular mechanism of intracellular trafficking of MMPs, with particular focus on MMP2. A novel mass spectrometry approach revealed nucleobindin-1 (NUCB1), a major regulator of Ca2+ homeostasis at the Golgi, as a potential candidate for the regulation of MMP transport. Using a synchronized cargo trafficking assay, it was possible to demonstrate that in the absence of NUCB1 the intracellular trafficking of MMP2 is delayed. Moreover, this work reveals that NUCB1-dependent MMP2 trafficking is restricted to the Golgi, exclusively delaying its intra-Golgi trafficking at the cis compartment and, as a consequence, decreasing MMP2 mediated cell migration and matrix invasion. Furthermore, my findings show that not only MMP2, but also MT1-MMP intra-Golgi trafficking is impaired, implying that this mechanism could also influence the trafficking of other MMPs. Interestingly, experiments performed with a NUCB1 Ca2+-binding deficient mutant showed that Ca2+ is required, both for the interaction, as well as for proper MMP2 trafficking, suggesting that a specific impairment of cis-Golgi Ca2+ homeostasis, rather than an overall Ca2+ deficiency, is essential for proper MMP2 intra-Golgi trafficking. Taken together the results of this thesis contributed to enlighten the mechanism of MMP2 intracellular trafficking by identifying NUCB1 as a critical player in MMP transport. Importantly, this work highlights the requirement of Ca2+ for proper trafficking, not just at the TGN, as has been documented, but also at the cis-Golgi. Although this is a big step towards the understanding of MMP intracellular trafficking, further investigations are required to gain a better understanding of the retention mechanism of NUCB1 at the cis-Golgi lumen and a deeper insight into the regulation of intra-Golgi protein trafficking
PATRONES DE DIVERSIDAD DE EPÍFITAS EN BOSQUES DE TIERRAS BAJAS Y SUBANDINOS
- Author
- Publication venue
- 'Universidad Distrital Francisco Jose de Caldas'
- Publication date
- 01/07/2012
- Field of study
Tropical rainforests are the most diverse ecosystems on the planet. Although many theories have been proposed to explain their richness we currently know little about their relative importance. This diversity is threatened by anthropogenic disturbances such as fragmentation and forest degradation. In this study we compared epiphytic plant diversity patterns in lowland and subandean forests. More epiphytic diversity was found in subandean (PNN Cueva de los Guácharos) compared to lowland forest (Palmarí Reserve). In addition a higher abundance of epiphytes was found in conserved forest. Tree host diversity was higher in lowland forests than in subandean forests, so we can reject the possibility that differences between the patterns of epiphytic diversity are caused by regional effects of plant diversity. Our results suggest that humidity seems to be the most important environmental filter explaining epiphyte diversity.Los bosques tropicales son los ecosistemas más diversos del planeta y aunque se han propuesto muchas teorías para explicar su riqueza, aún desconocemos gran parte de la importancia relativa de los factores que la afectan. Esta diversidad se encuentra amenazada por alteraciones de origen antrópico, como la fragmentación y la degradación de los bosques. En este estudio se comparan patrones de diversidad de epífitas en un bosque de tierras bajas y uno subandino. De esta manera, se encontró una mayor diversidad de epífitas en el bosque subandino (PNN Cueva de los Guacharos) comparado con el de tierras bajas (reserva Palmarí). Adicionalmente se encontró mayor abundancia de epífitas en los bosques más conservados. Dado que la diversidad de forofitos es mayor en el bosque de tierras bajas que en el subandino, se descarta la posibilidad de que las diferencias en los patrones encontrados se den por efectos regionales de diversidad de plantas. Se concluye que la humedad parece ser el filtro ambiental más importante para explicar la variación en diversidad de epífitas
Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2
- Author
- Abellán Javier
- Acosta-isaac René
- Aguado Jose María
- Aguilar Carlos
- Aguilera-albesa Sergio
- Ahmadi Sabbagh Abdolah
- Alba Jorge
- Albu Sergiu
- Alcalá-gallardo Karla A. M.
- Alcoba-florez Julia
- Alcolea Batres Sergio
- Algarin-lara Holmes Rafael
- Almadana Virginia
- Almeida Julia
- Almoguera Berta
- Alonso María R.
- Andreu-bernabeu Álvaro
- Antonijoan Maria Rosa
- Arana-arri Eunate
- Aranda Carlos
- Arango Celso
- Araque Carolina
- Araujo Izabel M. T.
- Araujo Nathalia K.
- Arcanjo Ana C.
- Arnaiz Ana
- Arnalich Fernández Francisco
- Arranz María J.
- Arribas López José Ramón
- Artiga Maria-jesús
- Avello-malaver Yubelly
- Ayuso Carmen
- Balagué-dobón Laura
- Baldion Ana María
- Ballina Martín Belén
- Baptista-rosas Raúl C.
- Barranco-díaz Andrea
- Barreda-sánchez María
- Barrera-penagos Viviana
- Belhassen-garcia Moncef
- Bernal Enrique
- Bernal-bello David
- Bezerra Joao F.
- Bezerra Marcos A. C.
- Blanca-lópez Natalia
- Blancas Rafael
- Boix-palop Lucía
- Borobia Alberto
- Bravo Elsa
- Brion María
- Brochado-kith Óscar
- Brugada Ramón
- Bustos Matilde
- Cabello Alfonso
- Calbo Esther
- Calderón Enrique J.
- Camacho Shirley
- Campos Marcela C.
- Carbonell Cristina
- Cardona-huerta Servando
- Carioca Antonio Augusto F.
- Carpio Segura Carlos
- Carracedo Ángel
- Carratto Thássia M. T.
- Carrillo-avila José Antonio
- Carvalho Maria C. C.
- Casasnovas Carlos
- Castaño Carlos F.
- Castaño Luis
- Castelao Jose E.
- Castellano Candalija Aranzazu
- Castillo María A.
- Cañadas Yolanda
- Ceballos Francisco C.
- Chaux Jessica G.
- Chaves-santiago Walter G.
- Chiquillo-gómez Sylena
- Cid-lópez Marco A.
- Cienfuegos-jiménez Óscar
- Conde-vicente Rosa
- Cordero-lorenzana M. Lourdes
- Corella Dolores
- Corrales Almudena
- Corton Marta
- Cortés-sánchez Jose L.
- Costa Tatiana X.
- Cruz Marina S.
- Cruz Raquel
- Cuesta Luisa
- Cunha Gabriela C. R.
- Cáceres Alejandro
- Cáceres-agra Juan J.
- Dalmau David
- Dantas-komatsu Raquel C. S.
- Darnaude M. Teresa
- De Andrés Raimundo
- De Araújo Jéssica N. G.
- De Juan Carmen
- De La Cruz Troca Juan J.
- De La Horra Carmen
- De La Hoz Ana B.
- De Martino-rodríguez Alba
- De Sousa Alves Neri Julianna Lys
- Del Campo-pérez Victor
- Delgado-cuesta Juan
- Diaz De Bustamante Aranzazu
- Dietl Beatriz
- Diz-de Almeida Silvia
- Do Monte Alves Manoella
- Domínguez-garrido Elena
- Dos Santos Katiusse A.
- Duarte Alice L.
- Díaz-caneja Covadonga M.
- Díaz-pérez Anderson
- Echave-sustaeta Jose
- Eiros Rocío
- Enciso-olivera César O.
- Escudero Gabriela
- Esko Tonu
- España Pedro Pablo
- Estigarribia Sanabria Gladys
- Fariñas María Carmen
- Fernandes Marianne R.
- Fernandez-nestosa María J.
- Fernández Martínez Yolanda
- Fernández Ramón
- Fernández Ruth
- Fernández-caballero Lidia
- Fernández-capitán Carmen
- Fernández-cruz Ana
- Fernández-ferrero Silvia
- Fernández-robelo Uxía
- Fernández-rodríguez Amanda
- Fernández-sampedro Marta
- Fernández-villa Tania
- Flores Carlos
- Flores-pérez Patricia
- Friaza Vicente
- Fuenmayor-hernández Lácides
- Fuertes-núñez Marta
- Fumadó Victoria
- Gadea Ignacio
- Gagliardi Lidia
- Gago-domínguez Manuela
- Gallego Natalia
- Galoppo Cristina
- Garcia-garcía Josefina
- García Torrejón María Carmen
- García Inés
- García Leticia
- García Mercedes
- García-cerrada Carlos
- García-de-vicuña Aitor
- García-garcía Irene
- García-ibarbia Carmen
- García-montero Andrés C.
- García-soidán Ana
- García-vázquez Elisa
- Garza-frias Emiliano
- Gentile Angela
- Gil-fournier Belén
- Gonzalez-sagrado Manuel
- Gonzalo-benito Hugo
- González Bernaldo De Quirós Fernán
- González Álvarez Beatriz
- González Juan R.
- González Juan R.
- González-montelongo Rafaela
- González-neira Anna
- González-peñas Javier
- Gorgojo-galindo Oscar
- Guaragna Florencia
- Guegel Genilson P.
- Guillén-guío Beatriz
- Guillén-navarro Encarna
- Guisado-vasco Pablo
- Gutiérrez-bautista Juan F.
- Gutiérrez-castañeda Luz D.
- Gómez Carrera Luis
- Gómez García María
- Gómez Sacristán Ángela
- Gómez-arrue Javier
- Gómez-duque Mario
- Górgolas Miguel
- Heili-frades Sara
- Hernández Estefania
- Hernández-moro Cristina
- Hernández-ortega Luis D.
- Hernández-pérez Guillermo
- Hernández-vaquero Rebeca
- Herranz M. Teresa
- Herrera María
- Herrero María José
- Herrero-gonzález Antonio
- Herráez Belén
- Horcajada Juan P.
- Imaz-ayo Natale
- Intxausti-urrutibeaskoa Maider
- Jacomo Rafael H.
- Jara Rubén
- Jiménez Pilar
- Jiménez Ángel
- Jiménez-alfaro Ignacio
- Jiménez-sousa María A.
- Jordan Iolanda
- Laguna-goya Rocío
- Laorden Daniel
- Lapunzina Pablo
- Lasa-lázaro María
- Lattig María Claudia
- Lauriente Ailen
- Liger Borja Anabel
- Llanos Lucía
- Lopez-garcia Esther
- Lopez-rodriguez Rosario
- Lorente Leonardo
- Lorenzo-salazar José M.
- Lozano José E.
- Lozano-espinosa María
- Luchessi Andre D.
- López De Heredia Miguel
- López De Heredia Miguel
- López-bernús Amparo
- López-granados Eduardo
- López-ruz Miguel A.
- Mahillo Ignacio
- Mancebo Esther
- Mar Carmen
- Marcelo Calvo Cristina
- Marcos Miguel
- Marcos-delgado Alba
- Mariscal-aguilar Pablo
- Martin-fernandez Marta
- Martin-pedraza Laura
- Martinez Amalia
- Martinez-paz Pedro
- Martín María Dolores
- Martín María M.
- Martín Vicente
- Martín-lópez Caridad
- Martín-oterino José-Ángel
- Martín-vicente María
- Martínez Juan José
- Martínez Ricardo
- Martínez Silvia
- Martínez-aquino Eleno
- Martínez-gonzález Óscar
- Martínez-lópez Iciar
- Martínez-nieto Óscar
- Martínez-pérez Ángel
- Martínez-ramas Andrea
- Martínez-reséndez Michel F.
- Martínez-robles Violeta
- Marzal Laura
- Marín-candón Alicia
- Maya Belén Rodríguez
- Mazzeu Juliana F.
- Medeiros Jeane F. P.
- Medeiros Kelliane A.
- Medrano Francisco J.
- Meijome Xose M.
- Mejuto-montero Natalia
- Mendes Ingrid
- Mendoza Charris Humberto
- Merayo Macías Eleuterio
- Mercadillo Fátima
- Mercado-sesma Arieh R.
- Molina Antonio J. J.
- Molina-roldán Elena
- Montoya Juan José
- Moraes Vitor M. S.
- Moreira-escriche Patricia
- Morelos-arnedo Xenia
- Moreno Cuerda Víctor
- Moreno Fernández Alberto
- Moreno Rocío
- Moreno-docón Antonio
- Moreno-escalante Junior
- Morilla Rubén
- Muñoz García Patricia
- Méndez-echevarría Ana
- Mínguez Pablo
- Neira Pablo
- Nevado Julián
- Nieto-gañán Israel
- Nunes Joana F. R.
- Nuñez-torres Rocío
- Obrador-hevia Antònia
- Ocejo-vinyals J. Gonzalo
- Olivar Virginia
- Oliveira Silviene F.
- Olivera María Rubio
- Ondo Lorena
- Orfao Alberto
- Ortega Luis
- Ortega-paino Eva
- Ortiz-flores Fernando
- Ortiz-lópez Rocío
- Oteo José A.
- Pacheco Manuel
- Pacheco-miranda Fredy Javier
- Padilla-conejo Irene
- Panadero-fajardo Sonia
- Parellada Mara
- Pariente-rodríguez Roberto
- Paz-artal Estela
- Peces-barba Germán
- Pedromingo Kus Miguel S.
- Perales Celia
- Perucho Teresa
- Pichardo Lisbeth A.
- Pinho Susana M. T.
- Pinsach-abuin Mel·lina
- Pinzón Luz Adriana
- Pita Guillermo
- Pla-juncà Francesc
- Planas-serra Laura
- Pompa-mera Ericka N.
- Porras-hurtado Gloria L.
- Pujol Aurora
- Pérez Alexandra
- Pérez César
- Pérez María Jazmín
- Pérez Patricia
- Pérez-de-nanclares Gustavo
- Pérez-garcía Felipe
- Pérez-jurado Luis A.
- Pérez-matute Patricia
- Pérez-tomás M. Elena
- Quevedo-chávez María Eugenia
- Quijada Maria Angeles
- Quintela Inés
- Quintela Inés
- Ramiro-león Soraya
- Rascado Sedes Pedro
- Recalde Delia
- Recio-fernández Emma
- Resino Salvador
- Riancho José A.
- Ribeiro Adriana P.
- Rivadeneira-chamorro Carlos S.
- Roa-agudelo Diana
- Robelo Pardo Montserrat
- Rodriguez Marilyn Johanna
- Rodriguez-nicolas Antonio
- Rodriguez-palmero Agustí
- Rodriguez-urrego Paula A.
- Rodríguez-artalejo Fernando
- Rodríguez-ferrer Marena
- Rodríguez-gallego Carlos
- Rodríguez-garcía José A.
- Rodríguez-hernández María A.
- Rodríguez-novoa German Ezequiel
- Rodríguez-ruiz Emilio
- Rojas-martinez Augusto
- Rojo Federico
- Romero-coronado Andrea
- Rondón-garcía Filomeno
- Rosa Lidia S.
- Rosales-castillo Antonio
- Rubio Cladelis
- Ruiz Montserrat
- Ruiz-cabello Francisco
- Ruiz-casares Eva
- Ruiz-cubillan Juan J.
- Ruiz-hornillos Javier
- Ryan Pablo
- Salamanca Hector D.
- Salazar-garcía Lorena
- Salgueiro-origlia Giorgina Gabriela
- Sancho-sainz Cristina
- Sande Esther
- Sangil Anna
- Santos Arnoldo
- Santos Ney P. C.
- Schlüter Agatha
- Scourge Cohort Group
- Segovia Sonia
- Serra-llovich Alex
- Sevil-puras Fernando
- Sevilla-porras Marta
- Sicolo Miguel A.
- Silbiger Vivian N.
- Silva Fabiola T. C.
- Silva Gabriela V.
- Silva Nayara S.
- Silván-fuentes Cristina
- Solé-violán Jordi
- Soria José Manuel
- Sorlí Jose V.
- Sousa Renata R.
- Souto Juan Carlos
- Souza Karla S. C.
- Souza Vanessa S.
- Sprockel John J.
- Suárez-rama José Javier
- Suárez-zamora David A.
- Sánchez López Antonio J.
- Sánchez Pedro-luis
- Sánchez-carpintero Abad María
- Sánchez-pablo Clara
- Sánchez-pernaute Olga
- Sánchez-prados María Concepción
- Sánchez-real Javier
- Sánchez-redondo Jorge
- Taboada-fraga Xiana
- Tamayo Eduardo
- Tamayo-velasco Alvaro
- Taracido-fernández Juan Carlos
- Tavares Nathali A. C.
- Tellería Carlos
- Tenorio-castaño Jair Antonio
- Teper Alejandro
- Torres-gutiérrez Ronald P.
- Torres-macho Juan
- Torres-tobar Lilian
- Troya Jesús
- Urioste Miguel
- Valencia-ramos Juan
- Valido Agustín
- Vargas-gallo Juan Pablo
- Varón Belén
- Vasconcelos Romero H. T.
- Vega Tomas
- Velasco-quirce Santiago
- Vidán-estévez Julia
- Vieitez-santiago Miriam
- Vilches Carlos
- Villalobos Lavinia
- Villar Felipe
- Villar-garcia Judit
- Villaverde Cristina
- Villoslada-blanco Pablo
- Virseda-berdices Ana
- Vélez-santamaría Valentina
- Víctor Virginia
- Yáñez Zuleima
- Zapatero-gaviria Antonio
- Zarate Ruth
- Zazo Sandra
- Álvarez Nuria
- Álvarez-benítez Yady
- Álvarez-navia Felipe
- Álvarez-sala Walther Rodolfo
- Íñigo-campos Antonio
- Íñiguez María
- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 08/05/2024
- Field of study
The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality
Procesos de subjetivación del género: una experiencia desde la Investigación Basada en Artes
- Author
- Andrade Riaño Mary Julieth
- Arcila Gallego Jorge Tadeo
- Benavides Buitrago Chaterine
- Chacón Pinilla Ruth Stella
- Correa Toro Adriana
- Cortés Salcedo Ruth Amanda
- Forero Duarte María Teresa
- Latorre Kañizares Kenia Karolina
- Madrigal Cogollo Martha Liliana
- Ordóñez de Valdés Stephany Parra
- Pinilla Cortés Anjie Natalia
- Pinto Torres Fernando
- Ramírez Aristizábal Fidel Mauricio
- Ramírez Segura Darío Fernández
- Riaño Herrera Claudia Emilse
- Rueda Pacheco Fanny
- Sabogal Pulido Carmen Edilma
- Álvarez Bautista Adriana Lucía
- Publication venue
- Editorial Universidad El Bosque
- Publication date
- 01/01/2023
- Field of study
284 p.
Libro ElectrónicoPrimera EdicionEste libro, resultado de investigación, fue elaborado en el marco del Convenio Ciencia y Tecnología No. 58 de 2022 suscrito entre el Instituto para la Investigación Educativa y el Desarrollo Pedagógico (IDEP) y la Universidad El Bosque, con el objeto de “Anuar esfuerzos para desarrollar la Investigación Arte, Género y Educación 2022”, en el marco de la Agenda de Investigaciones para la Transformación Pedagógica
Plasma lipid profiles discriminate bacterial from viral infection in febrile children
- Author
- Abdulla Amina F.
- Abelake Eugenia
- Adeel Abdul O.A.
- Aebi C.
- Agapow Paul Michael
- Agbeko R.
- Agyeman P.
- Anderson Suzanne T. B.
- Antonio Martin
- Baer W.
- Barham Heather
- Barral-Arca Ruth
- Barrios Xavier Gabaldó
- Bartlett Maeve
- Baumgart Hinrich
- Baumgartner Markus
- Behrends Uta
- Bellos Evangelos
- Berger C.
- Bernhard-Stirnemann S.
- Biebl Ariane
- Binder Alexander
- Birnbacher Robert
- Blanke Jan-Gerd
- Boeddha Navin P.
- Boelke Carsten
- Bojang Kalifa
- Bokhandi Sumit S.
- Breukels Meike A.
- Breuling Kai
- Brinkman Daniëlle M.C.
- Brió Sanagustín Sonia
- Brunner Jürgen
- Buller Maria
- Camuzeaux Stephane
- Carreras Eduardo
- Carrol Enitan
- Carter Stephanie
- Cebey-López Miriam
- Coin Lachlan
- Cole Fatoumata
- Concha-Torre Andres
- Contreras J. Ruiz
- Cooke Elizabeth Fernández
- Crate Lindsay
- Curras-Tuala MJ.
- Dahlem Peter
- Davies Patrick
- de Groot Ronald C.A.
- de Korte Carla C.M.M.
- de Vries Esther
- de Waal Wouter J.
- Deep Akash
- Dekkers Roel
- Dietrich Beate
- Dings-Lammertink Anouk
- Doedens Rienus A.
- Donker AlbertineE.
- Dousma Mieke
- Driessen Gertjan Jan A.
- Eber Ernst
- Eleftherohorinou Hariklia
- Elias Johannes
- Ellacuriagal Antonio Salas
- Emhofer Josef
- Emonts Marieke
- Etschmaier Rosa
- Faber Tina E.
- Farr Sebastian
- Faust Saul
- Fernandez Silveira Laura
- Fernández Reyes
- Fink Colin
- Forte Miguel Sanchez
- Fortune Peter-Marc
- Frederick H.
- Galassini Rachel
- García Natalia
- Gerrits Gerardus Peter Jm M.
- Gerver Jan A.M.
- Giannoni E.
- Giménez-Sánchez Francisco
- Girtler Ylenia
- Gomez-Rial Jose
- Gormley Stuart
- Grela Beiroa Andrea
- Gribbin Andrew
- Grigorow Irina
- Guillén Sara
- Gómez-Carballa Alberto
- Hamilton Shea
- Hardy Katie
- Hasters P.
- Hazelzet Jan
- Heidema Jojanneke
- Heimann Konrad
- Heininger U.
- Herberg Jethro A.
- Hoggart Clive
- Hourmat Bernardo
- Hudnott Phil
- Ibarrondo Cristina Epalza
- Iglesias Pilar Leboráns
- Ihm Ulrike
- Inwald David
- Jackson Heather R.
- Jacobs Monique A.M.
- Jansen Nicolaas Johannes Georgius
- Jaros Zdenek
- Jennings R.
- Johnston J.
- Justicia-Grande Antonio
- Kaforou Myrsini
- Kahlert C.
- Kalhoff Hermann
- Kaulfersch Wilhelm
- Kawczynski Pawel
- Kebbeh Ngange
- Kemen Christoph
- Kenwright R.
- khan Saidy
- Klobassa Daniela S.
- Klocker Nina
- Klucovska Kristine
- Kneyber Martin Christiaan Jacques
- Kohlmaier B.
- Komini Eleni
- Koopman-Keemink Yvonne
- Kramer Lydia
- Kuijpers T. W.
- Köster Bernhard
- Langenhorst Veerle J.
- Leusink José
- Levin Michael
- Lewis Matthew R.
- León-León María Cruz
- Loza Bettina F.
- Lozano María José
- Maconochie Ian
- Martinez-Santos Alba-Elena
- Martinon-Torres Federico
- MartinónTorres Nazareth
- Mashbat Meg
- McClure Myra
- McCorkell Jenni
- McCready Sharon
- Menikou Stephanie
- Merth Istvan T.
- Miedema Carien J.
- Mingorance Álvaro Navarro
- Momodou None
- Moreno David
- Morillo Gutiérrez Beatriz
- Mustafa Sobia
- Nadel Simon
- Navarra Helen
- Navarro Marisa
- Neeleman Chris
- Neth Olaf
- Neubert Antje
- Niederer-Loher A.
- Nijman Ruud Gerard
- Noordzij Jeroen G.
- Nsirim Eniola
- O'Neill Lauren
- Obihara Charlie C.C.
- Ortner Daniel
- Oñate Vergara Eider
- Pacheco Pablo Obando
- Padilla Ma del Carmen Martínez
- Pajkrt Dasja
- Palacios Alba
- Pardo-Seco Jacobo
- Patel Rekha
- Patel Sanjay Valabh
- Pathan Nazima
- Paulus Stéphane
- Pescollderungg Lydia
- Peters Mark
- Pfurtscheller Klaus
- Philipsen H.L.A.
- Pinnock Elli
- Pischedda Sara
- Pollard AJ.
- Poortman Geriska H.
- Posfay-Barbe K.M.
- Potgieter Steph T.
- Potjewijd Joke
- Power Sue
- Pérez Belén Mosquera
- Rahman Rahmeen
- Ramaiah Raghu
- Redondo Collazo Lorenzo
- Reiter Karl
- Relly C.
- Reyes Susana Beatriz
- Ridout Jenna
- Ristic Goran
- Rivero Calle Irene
- Rodríguez-Tenreiro Carmen
- Rojo Pablo
- Rosias Philippe P.R.
- Royad C.
- Rödl Siegfried
- Sagmeister Manfred
- Salas Antonio
- Sancho Shimizu Vanessa
- Sanders Elisabeth A. M.
- Sands Caroline
- Sarr Isatou
- Schlapbach Luregn
- Schweintzger Nina
- Secka Fatou
- Sellner Andrea
- Serén Fernández Sonia
- Sey Gibbi
- Silva María Del Sol Porto
- Sonnleitner Astrid
- Sperl Matthias
- Sprong Tom
- Standing Fran
- Stelzl Wolfgang
- Stocker M.
- Sánchez José María
- Tato Luis Manuel Prieto
- ten Tussher Gavin W.
- Thakker Clare
- Thio Bernard J.
- Thomas Gilleh
- Thurston Sarah
- Till Holger Karl H.
- Tramper-Stranders Gerdien A.
- Trobisch Andreas
- Tuffrey Catherine
- Universitat Autònoma de Barcelona
- van de Beek Diederik
- van der Ende Arie
- Van der Flier Michiel
- van der Meer H.
- van Deuren M.
- van Furth Marceline
- van Kuppevelt A.J.M.
- van Overbeek - van Gils A. Lidy T.
- van Wermeskerken A.M.
- Veen J. Homan-van der
- Vega Ana Karina
- Verwijs W.A.
- Vicente Luisa García
- Vierzig Anne
- Vilanova-Trillo Lucía
- Vivanco Ana
- Vogel Ulrich
- Wang Xinzhu
- Weingarten Christina
- Welke Stefanie
- White Deborah K.
- White Sonia
- Willis Louise
- Wimmer Andreas
- Wintergerst Uwe
- Wolfs T.F.W.
- Wright Victoria
- Wüller Daniel
- Young Zoe
- Zaunschirm Andrew
- Zenz Werner
- Ziuraite Ieva
- Álvarez Cristina Álvarez
- Álvez González Fernando
- Žukovskaja Veslava
- Publication venue
- Publication date
- 01/01/2019
- Field of study
Fever is the most common reason that children present to Emergency Departments. Clinical signs and symptoms suggestive of bacterial infection are often non-specific, and there is no definitive test for the accurate diagnosis of infection. The 'omics' approaches to identifying biomarkers from the host-response to bacterial infection are promising. In this study, lipidomic analysis was carried out with plasma samples obtained from febrile children with confirmed bacterial infection (n = 20) and confirmed viral infection (n = 20). We show for the first time that bacterial and viral infection produces distinct profile in the host lipidome. Some species of glycerophosphoinositol, sphingomyelin, lysophosphatidylcholine and cholesterol sulfate were higher in the confirmed virus infected group, while some species of fatty acids, glycerophosphocholine, glycerophosphoserine, lactosylceramide and bilirubin were lower in the confirmed virus infected group when compared with confirmed bacterial infected group. A combination of three lipids achieved an area under the receiver operating characteristic (ROC) curve of 0.911 (95% CI 0.81 to 0.98). This pilot study demonstrates the potential of metabolic biomarkers to assist clinicians in distinguishing bacterial from viral infection in febrile children, to facilitate effective clinical management and to the limit inappropriate use of antibiotics
Canagliflozin and renal outcomes in type 2 diabetes and nephropathy
- Author
- A Kaldun Nossuli
- Aamir Jamal
- Adalbert Schiller
- Adam Cheifetz
- Adarsh Daswani
- Adeera Levin
- Adline Ghazi
- Adrian Guinsburg
- Adriana Cif
- Adriana Gabriela Onaca
- Adriana Ilavska
- Adriana Villarino
- Agarwal R.
- Agnieszka Starzec
- Ahmed Arif
- Ahmed Awad
- Aiping Yin
- Akimichi Asano
- Alan Jackson
- Alan McMahon
- Alan Perlman
- Alberto Di Carlo
- Alberto Esquenazi
- Alejandra Oviedo
- Alejandro Valdes Depeda
- Aleksandra Kendereski
- Alex Valenzuela
- Alexander Dreval
- Alexander Gonzalez
- Alexander Shinkov
- Alexander Turchin
- Alexandre Klein
- Alfonso Soto Gonzalez
- Alfred Penfornis
- Alfredo Chew Wong
- Alfredo Wassermann
- Ali Torshizi
- Alicia Chilito
- Alina Agafyina
- Alison Dawson
- Alva Hansraj
- Amer Al-Karadsheh
- Amorin Remus Popa
- Amrendra Kumar
- Amy Sprague
- Ana Limos
- Ana Maria Cusumano
- Ana Maria Elosegui
- Anabella Amigo
- Anatoliy Kazmirchuk
- Andrea Phillips
- Andrea Stella
- Andreas Maddux
- Andrej Dzupina
- Andres Alvarisqueta
- Andrew Johnson
- Andrew O'Shaughnessy
- Andrew Steele
- Andrian Yakov
- Andrzej Januszewicz
- Andrzej Madej
- Angelina Angelova
- Anibal Gastaldi
- Anil Gupta
- Anita Bhajan Manocha
- Anjanette Tan
- Anna Kaminska
- Anna Maria Veronelli
- Anna Strzelecka
- Anna Zateyshchikova
- Anselmo Bordonava
- Antanas Navickas
- Anthony Gunstone
- Anthony Roberts
- Antonio Ceriello
- Antonio Galan Serrano
- Antonio Scafuto Scotton
- Antonio Terrelonge
- Antônio Roberto Chacra
- Anupama Gowda
- Arjun D Sinha
- Armando Perez
- Ashot Mkrtumyan
- Atanas Koundurdjiev
- Augusto Vallejos
- Aurelian-Emil Ranetti
- Ayim Akyea-Djamson
- Aysha Badat
- Bakris G.
- Baldev Singh
- Barbara Greco
- Barbara Kaczmarek
- Barbara Rewerska
- Barry M Brenner
- Belia Martin Del Camp Blanco
- Bernard Zinman
- Bertrand Cariou
- Bertrand Dussol
- Bhasker Mehta
- Bhimavarapu Sudhakar
- Björn Paschen
- Bompoint S.
- Borys Mankovskyy
- Botond Csiky
- Boyan Nonchev
- Brenner B. M.
- Brett Kissela
- Brian Nichol
- Bruce Neal
- Bruce Trippe
- Bruno Geloneze Neto
- Bull S.
- Byung-Wan Lee
- C B Keshavamurthy
- Cannon C. P.
- Capuano G.
- Carlo Giorda
- Carlos Alberto Cuneo
- Carlos Arauz-Pacheco
- Carlos Barrera
- Carlos Perez
- Carmel Hawley
- Carmen Crisan
- Carol Pollock
- Carolyn Droste
- Caroucel Chuateco
- Caryl David
- Cecilia Garcia Ballesteros
- Cecilia Jimeno
- Celso Amodeo
- Cesar Javier Zaidman
- Cesar Yoiti Hayashida
- Chamberlain Obialo
- Chang-Hsun Hsieh
- Charles Cook
- Charles Kaupke
- Charytan D. M.
- Chek Loong Loh
- Chen Leia
- Cheol-Young Park
- Chih-Ching Lin
- Christopher P Cannon
- Christy Yao
- Chu P. -L.
- Chwen-Tzuei Chang
- Chye Lee Gan
- Clara Barrios
- Claude Galphin
- Claudia Goycoa
- Claudia Moreira de Brito
- Clodoaido Caringal
- Cristian Serafinceanu
- Cristina Toarba
- Cristobal Morales Portillo
- Csaba Kovesdy
- Cynthia Bowman-Stroud
- Cynthia Christiano
- Cynthia Mustieles Rocha
- Cyrus Desouza
- Cássio Slompo Ramos
- Dagmar Bartaskova
- Dale Crawford Allison
- Dalia Kozloviene
- Dan Scharfstein
- Dana Cosma
- Daniel Coyne
- Daniel Hiser
- Daniel Kolansky
- Daniel Panarotto
- Daniel Pella
- Daniel Weiner
- Daniil Chizhov
- Dariusz Sowinski
- Darren K McGuire
- Davesh Sennik
- David C Wheeler
- David Cherney 3rd
- David Gorson
- David Johnson
- David M Charytan
- David Packham
- David Scott
- David Wheeler
- De Zeeuw D.
- Debbie Cohen-Stein
- Debbie Mascaro
- Deepak Koppolu
- Dennis Levinson
- Derek Lewis
- Detian Li
- Devasmita Dev
- Devesh Patel
- Dewan Deepak
- Dick de Zeeuw
- Diego Aizenberg
- Dinesh Jain
- Dinesh Khullar
- Diogo Belo
- Dmitry Zateyshshikov
- Domenico Santoro
- Domingos d'Avila
- Donald Brandon
- Donald Fraser
- Dong-Wan Chae
- Dora Inés Molina de Salazar
- Dorota Mlodawska-Choluj
- Doru Negru
- Edgar Arcos
- Edoardo Mannucci
- Eduardo Farias
- Edward Watson
- Edwards R.
- Egle Gaupsiene
- Egle Urbanaviciene
- Ekaterina Velichkova
- Elena Christofides
- Elena Grineva
- Elena Kolmakova
- Elena Shutemova
- Eleonora Harcsa
- Elizabeth Barranco
- Elizabeth Gelersztein
- Elizabeth Kern
- Elizete Keitel
- Eloisa Tellez Chavez
- Emanuela Orsi
- Emil Martinka
- Emyr Davies
- Enrique Gonzalez
- Eric Alamartine
- Eric Hernandez Triana
- Eric Thervet
- Erick Turcios Juarez
- Esteban Cercos
- Eugenia Galindo-Ramos
- Eva Peterfai
- Evaly Chen
- Evandro de Souza Portes
- Evgueniy Vazelov
- Fabian Otreras
- Fabiana Loss de Carvalho Contieri
- Fabio Malberti
- Fadi Saba
- Fadlo Fraige Filho
- Favio Edmundo Enriquez Sosa
- Fayzal Ahmed
- Ferdinando Carlo Sasso
- Fernanco Augusto Alves da Costa
- Fernanda Cristina Camelo Sanches
- Fernando Cereto Castro
- Fernando Flores Lozano
- Fernando Jimenez Florez
- Fernando Krynski
- Fernando M Edwin
- Fernando Thomé
- Fernando Trespalacios
- Florence Santos
- Florencia Kraft
- Fracisco Javier Gonzalez Martinez
- Fran Morren
- Franciso Jose Tinahones Madueno
- Frank Eder
- Franklin Joseph
- Franklin Paul Haase
- Frantisek Saudek
- François Dubé
- François Madore
- Freemu Varghese
- Gabriela Cecilia Coloma
- Gabriela Genova-Hristova
- Gabriele von Ingersleben
- Gaetano Serviddio
- Galina Nagibovich
- Gary Meininger
- Gema Fernandez Fresnedo
- Georg Plassmann
- George Bakris
- George Hon
- George Newman
- Gerald DaRoza
- Gerald Keightley
- Gerry Tan
- Giacomo Garibotto
- Giorgio Fuiano
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- Giovanni Gambaro
- Giuseppe Derosa
- Gizella Petro
- Glenn Chertow
- Gnyandev Patel
- Godwin Simon
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- Gopal Krishna
- Grace Aquitania
- Grace Lin
- Graham Hillis
- Graziano Di Cianni
- Grazyna Orlowska-Kowalik
- Grazyna Popenda
- Greene T.
- Greg Fulcher
- Gregorio Obrador
- Gregorio Obrador Vera
- Grit Faulmann
- Guadalupe Morales Franco
- Guillermo Fragale
- Guixia Wang
- Gulam Latiff
- Gustavo Cristian Greloni
- Guy Chouinard
- Gyongyi Csecsei
- Gyorgy Paragh
- Halyna Tomashkevych
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- Harpreet Bajaj
- Hasnain Khandwala
- Hector Rodriguez
- Heerspink H. J. L.
- Helena Oosthuizen
- Hendrik Nortje
- Henry Watson
- Hermann Haller
- Hernan Finkelstein
- Hernan Yupanqui
- Hiddo J L Heerspink
- Hiralal Maheshwari
- Hiroko Oishi
- Hiromi Aoki
- Hiromi Rodriguez Pattzi
- Hiroshi Kono
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- Hong Mao
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- Ioana Emilia Ferariu
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- Isabel Garcia
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- James Welker
- Jan Culak
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- Jana Belobradkova
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- Jardine M. J.
- Jason Gaglia
- Javier Narvarte
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- Jiao Sun
- Jinkui Yang
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- Joseph Feuerstein
- Joseph O'Hare
- Joseph Proietto
- Josier Nisnisan
- José Vicente Sanchez Polo
- João Lindolfo Cunha Borges
- João Soares Felício
- Juan Alfredo Tamayo Y Orozco
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- Juan Frias
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- Juan Villagordoa Mesa
- JungEun Lee
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- Kazunori Koyama
- Kazuyuki Mizuyama
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- Kenneth W Mahaffey
- Khalid Abdul Kadir
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- Kim Travis
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- Krisztian Kiss
- Kun Ho Yoon
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- Li Yuan Lee
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- Meg Jardine
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- Sunil Sheth
- Susumu Kashine
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- Sérgio Yamada
- Tadashi Iitsuka
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- Vijayaraman Arutchelvam
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- Vimladhevi Govender
- Vincent Pichette
- Vincent Woo
- Vira Tseluyko
- Virginia Esther Visco
- Vivek Sood
- Vivekan Jha
- Vladimir Dobronravov
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- Vladimir Tesar
- Vlado Perkovic
- Volker Burst
- Volodymyr Botsyurko
- Walter Guillermo Douthat
- Walter Pharr
- Wasim Hanif
- Wataru Yumita
- Wayne H-H Sheu
- Wayne Turner
- Wei Yen Kong
- Weihong Song
- Weiping Lu
- Wendy Lane
- Wenge Li
- Wheeler D. C.
- Wladmir Saporito
- Xuemei Li
- Xueqing Yu
- Yamil Canaan
- Yan Ren
- Yannick Le Meur
- Yaozhong Kong
- Yasuro Kumeda
- Yasushi Wakida
- Yavin Y.
- Yeong Hoon Kim
- Yevgeniya Svyshchenko
- Young Min Cho
- Yulia Samoylova
- Yung-Chuan Lu
- Yuriy Mostovoy
- Yuriy Shwartz
- Yvette Ethel Yap
- Zaynab Abejuela
- Zdravko Kamenov
- Zeid Khitan
- Zhang H.
- Zinman B.
- Zishan Ali
- Zuzana Ochodnicka
- Ângela Regina Nazario Sabbag
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2019
- Field of study
BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to <90 ml per minute per 1.73 m2 of body-surface area and albuminuria (ratio of albumin [mg] to creatinine [g], >300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years
Plasma lipid profiles discriminate bacterial from viral infection in febrile children
- Author
- Abdulla A. (Amina)
- Abelake E. (Eugenia)
- Adeel A.O.A. (A. O.A.)
- Aebi C. (Christoph)
- Aebi C. (Christoph)
- Agapow P. (Paul)
- Agbeko R. (Rachel)
- Agyeman P. (Philipp)
- Anderson S. (Suzanne)
- Antonio M. (Martin)
- Baer W. (Walter)
- Barham H. (Heather)
- Barral-Arca R. (Ruth)
- Barrios X.G. (Xavier Gabaldó)
- Bartlett M. (Maeve)
- Baumgart H. (Hinrich)
- Baumgartner M. (Markus)
- Behrends U. (Uta)
- Beiroa A.G. (Andrea Grela)
- Bellos E. (Evangelos)
- Berger C. (Christoph)
- Berger C. (Christoph)
- Bernhard-Stirnemann S. (Sara)
- Biebl A. (Ariane)
- Binder A. (Alexander)
- Birnbacher R. (Robert)
- Blanke J.-G. (Jan-Gerd)
- Boeddha N.P. (Navin)
- Boelke C. (Carsten)
- Bojang K. (Kalifa)
- Bokhandi S. (S.)
- Breukels M.A. (M. A.)
- Breuling K. (Kai)
- Brinkman D.M.C.
- Brunner J. (Jürgen)
- Buller M. (Maria)
- Camuzeaux S. (Stephane)
- Carreras E. (Eduardo)
- Carrol E.D. (Enitan)
- Carter S. (Stephanie)
- Cebey-López M. (Miriam)
- Coin L.M.J. (Lachlan M. J.)
- Cole F. (Fatoumata)
- Contreras J.R. (J. Ruiz)
- Cooke E.F. (Elizabeth Fernández)
- Crate L. (Lindsey)
- Curras-Tuala M.J. (María José)
- Dahlem P. (Peter)
- Davies P. (P.)
- de Korte C.C.M.M. (C. C.M.M.)
- de Vries E. (E.)
- Deep A. (Akash)
- Dekkers R. (R.)
- Deuren M. (Marcel) van
- Dietrich B. (Beate)
- Dings-Lammertink A. (A.)
- Doedens R.A. (R. A.)
- Donker A.E. (A.)
- Dousma M. (M.)
- Driessen G.J.A. (Gertjan)
- Eber E. (Ernst)
- Eleftherohorinou H. (Hariklia)
- Elias J. (Johannes)
- Ellacuriagal A.S. (Antonio Salas)
- Emhofer J. (Josef)
- Emonts M. (Marieke)
- Emonts M. (Marieke)
- Ende A. (A.) van der
- Etschmaier R. (Rosa)
- Faber T.E. (T. E.)
- Farr S. (Sebastian)
- Faust D. (Dominik)
- Fernández R. (Reyes)
- Fernández S.S. (Sonia Serén)
- Fink C. (Colin)
- Flier M. (Michiel) van der
- Forte M.S. (Miguel Sánchez)
- Fortune P.M. (P. M.)
- Frederick H. (Hannah)
- Galassini R. (Rachel)
- García N. (Natalia)
- Gerrit G.P.J.M. (Gerardus)
- Gerver J.A.M. (J. A.M.)
- Giannoni P.
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- Gormley S. (Stuart)
- Grande A.J. (Antonio Justicia)
- Gribbin A. (Andrew)
- Grigorow I. (Irina)
- Groot R. (Ronald) de
- Guillén S. (Sara)
- Gutiérrez B.M. (Beatriz Morillo)
- Gómez-Carballa A. (Alberto)
- Hamilton S. (Shea)
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- Hasters P. (Paul)
- Hazelzet J.A. (Jan)
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- Jansen N.J.G. (N. J.G.)
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- Kaulfersch W. (Wilhelm)
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- Kebbeh N. (Ngange)
- Kemen C. (Christoph)
- Kenwright R. (Rhian)
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- Klocker N. (Nina)
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- Kneyber M.C.J. (M. C.J.)
- Kohlmaier B. (Benno)
- Komini E. (Eleni)
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- Köster B. (Bernhard)
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- Leusink J. (J.)
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- Lewis M.R. (Matthew R.)
- León M.C.L. (María Cruz León)
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- Lozano M.J. (María José)
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- Nsirim E. (Eniola)
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- Paulus S.C. (Stephane C.)
- Pescollderungg L. (Lydia)
- Peters M. (Mark)
- Pfurtscheller K. (Klaus)
- Philipsen H.L.A. (H. L.A.)
- Pinnock E. (Elli)
- Pischedda S. (Sara)
- Pollard A.J. (Andrew J.)
- Poortman G.H. (G. H.)
- Posfay-Barbe K.M. (Klara M.)
- Potgieter S.T. (S. T.)
- Potjewijd J. (J.)
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- Pérez B.M. (Belén Mosquera)
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- Ristic G. (Goran)
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- Rodríguez-Tenreiro C. (Carmen)
- Rojo P. (Pablo)
- Rosias P.P.R. (Philippe)
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- Rödl S. (Siegfried)
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- Schlapbach L.J. (Luregn)
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- Secka F. (Fatou)
- Sellner A. (Andrea)
- Sey G. (Gibbi)
- Silva M.S.P. (María del Sol Porto)
- Silveira L.F. (Laura Fernández)
- Sonnleitner A. (Astrid)
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- Standing F. (Fran)
- Stelzl W. (Wolfgang)
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- Sánchez F.G. (Francisco Giménez)
- Sánchez J.M.M. (José María Martinón)
- Tato L.M.P. (Luis Manuel Prieto)
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- Thakker C. (Clare)
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- Thomas G. (Gilleh)
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- Till H. (Holger)
- Torre A.C. (Andrés Concha)
- Tramper-Stranders G.A. (Gerdien)
- Trillo L.V. (Lucía Vilanova)
- Trobisch A. (Andreas)
- Tuffrey C. (Catherine)
- van de Beek D. (D.)
- van der Meer H. (H.)
- van Furth A.M.T. (A. M. Tutu)
- van Kuppevelt A.J.M. (A. J.M.)
- van Overbeek – van Gils A.L.T. (A. L.T.)
- van Wermeskerken A.M. (A. M.)
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- Vergara E.O. (Eider Oñate)
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- Vicente L.G. (Luisa García)
- Vierzig A. (Anne)
- Vivanco A. (Ana)
- Vogel U. (Ulrich)
- Waal W.J. (Wouter) de
- Wang X. (Xinzhu)
- Weingarten C. (Christina)
- Welke S. (Stefanie)
- White D. (Deborah)
- White S. (Sonia)
- Willis L. (Louise)
- Wimmer A. (Andreas)
- Wintergerst U. (Uwe)
- Wolfs T.F.W. (T. F.W.)
- Wright V.J. (Victoria)
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- Young Z. (Zoe)
- Zaunschirm A. (Andrew)
- Zenz W. (Werner)
- Ziuraite I. (Ieva)
- Álvarez C.Á. (Cristina Álvarez)
- Žukovskaja V. (Veslava)
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/12/2019
- Field of study
Fever is the most common reason that children present to Emergency Departments. Clinical signs and symptoms suggestive of bacterial infection ar
Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight NCD Risk Factor Collaboration (NCD-RisC)
- Author
- Abarca-Gómez Leandra
- Abdeen Ziad A
- Abdrakhmanova Shynar
- Abu-Rmeileh Niveen M
- Acosta-Cazares Benjamin
- Adams Robert J
- Aekplakorn Wichai
- Afsana Kaosar
- Afzal Shoaib
- Agdeppa Imelda A
- Aghazadeh-Attari Javad
- Aguilar-Salinas Carlos A
- Agyemang Charles
- Ahmad Mohamad Hasnan
- Ahmad Noor Ani
- Ahmadi Ali
- Ahmadi Naser
- Ahmed Soheir H
- Ahrens Wolfgang
- Aitmurzaeva Gulmira
- Ajlouni Kamel
- Al Nsour Mohannad
- Al-Hazzaa Hazzaa M
- Al-Lahou Badreya
- Al-Raddadi Rajaa
- Alarouj Monira
- AlBuhairan Fadia
- AlDhukair Shahla
- Ali Mohamed M
- Alkandari Abdullah
- Alkerwi Ala'a
- Allin Kristine
- Alvarez-Pedrerol Mar
- Aly Eman
- Amarapurkar Deepak N
- Amiri Parisa
- Amougou Norbert
- Amouyel Philippe
- Anderssen Sigmund A
- Anjana Ranjit Mohan
- Ansari-Moghaddam Alireza
- Aounallah-Skhiri Hajer
- Araújo Joana
- Ariansen Inger
- Aris Tahir
- Arku Raphael E
- Arlappa Nimmathota
- Aryal Krishna K
- Aspelund Thor
- Assah Felix K
- Assunção Maria Cecília F
- Aung May Soe
- Auvinen Juha
- Avdicová Mária
- Avi Shina
- Azevedo Ana
- Azimi-Nezhad Mohsen
- Azizi Fereidoun
- Azmin Mehrdad
- Babu Bontha V
- Baharudin Azli
- Bahijri Suhad
- Baker Jennifer L
- Balakrishna Nagalla
- Bamoshmoosh Mohamed
- Banach Maciej
- Bandosz Piotr
- Banegas José R
- Bao Tran Quoc
- Baran Joanna
- Barbagallo Carlo M
- Barceló Alberto
- Barkat Amina
- Barros Aluisio JD
- Barros Mauro Virgílio Gomes
- Basit Abdul
- Bastos Joao Luiz D
- Bata Iqbal
- Batieha Anwar M
- Batista Rosangela L
- Battakova Zhamilya
- Batyrbek Assembekov
- Baur Louise A
- Beaglehole Robert
- Bebakar Wan Mohamad Wan
- Bel-Serrat Silvia
- Belavendra Antonisamy
- Benchekor Sounnia Mediene
- Benedics Judith
- Benet Mikhail
- Bennett James E
- Bergh Ingunn Holden
- Berkinbayev Salim
- Bernabe-Ortiz Antonio
- Bernotiene Gailute
- Bettiol Heloísa
- Bezerra Jorge
- Bhagyalaxmi Aroor
- Bharadwaj Sumit
- Bhargava Santosh K
- Bhutta Zulfiqar A
- Bi Hongsheng
- Bi Yufang
- Bia Daniel
- Bikbov Mukharram M
- Bista Bihungum
- Bixby Honor
- Bjelica Dusko J
- Bjerregaard Peter
- Bjertness Espen
- Bjertness Marius B
- Björkelund Cecilia
- Bloch Katia V
- Blokstra Anneke
- Bo Andersen Lars
- Bo Simona
- Bobak Martin
- Boddy Lynne M
- Boehm Bernhard O
- Boeing Heiner
- Boggia Jose G
- Bogova Elena
- Boissonnet Carlos P
- Bojesen Stig E
- Boker Lital Keinan
- Bonaccio Marialaura
- Bongard Vanina
- Bonilla-Vargas Alice
- Bopp Matthias
- Borghs Herman
- Bovet Pascal
- Braeckevelt Lien
- Braeckman Lutgart
- Bragt Marjolijn CE
- Brajkovich Imperia
- Branca Francesco
- Braunerová Radka Taxová
- Breckenkamp Juergen
- Breda João
- Brenner Hermann
- Brewster Lizzy M
- Brian Garry R
- Brinduse Lacramioara
- Brophy Sinead
- Bruno Graziella
- Bueno-de-Mesquita H Bas
- Bugge Anna
- Buoncristiano Marta
- Burazeri Genc
- Burns Con
- Cacciottolo Joseph
- Cadena Leticia Hernandez
- Cai Hui
- Cama Tilema
- Cameron Christine
- Camolas José
- Can Günay
- Capanzana Mario V
- Capková Nadežda
- Capuano Eduardo
- Capuano Vincenzo
- Cardol Marloes
- Cardoso Viviane C
- Carlsson Axel C
- Carmuega Esteban
- Carrillo-Larco Rodrigo M
- Carvalho Joana
- Casajús José A
- Casanueva Felipe F
- Cañete Felicia
- Celikcan Ertugrul
- Censi Laura
- Cervantes-Loaiza Marvin
- Cesar Juraci A
- Chamukuttan Snehalatha
- Chan Angelique W
- Chan Queenie
- Chaturvedi Himanshu K
- Chaturvedi Nish
- Chen Chien-Jen
- Chen Fangfang
- Chen Huashuai
- Chen Shuohua
- Chen Zhengming
- Cheng Ching-Yu
- Cheraghian Bahman
- Chetrit Angela
- Chikova-Iscener Ekaterina
- Chiolero Arnaud
- Chiou Shu-Ti
- Chirita-Emandi Adela
- Chirlaque María-Dolores
- Cho Belong
- Christensen Kaare
- Christofaro Diego G
- Chudek Jerzy
- Cifkova Renata
- Cilia Michelle
- Cinteza Eliza
- Cisneros Julio Zuñiga
- Claessens Frank
- Clarke Janine
- Clays Els
- Cohen Emmanuel
- Concin Hans
- Confortin Susana C
- Cooper Cyrus
- Coppinger Tara C
- Corpeleijn Eva
- Costanzo Simona
- Cottel Dominique
- Cowan Melanie J
- Cowell Chris
- Craig Cora L
- Crampin Amelia C
- Crujeiras Ana B
- Csilla Semánová
- Cucu Alexandra M
- Cui Liufu
- Cureau Felipe V
- Czenczek-Lewandowska Ewelina
- Cândido Ana Paula C
- D'Arrigo Graziella
- d'Orsi Eleonora
- da Silva Bruna Goncalves Cordeiro
- Dacica Liliana
- Dallongeville Jean
- Damasceno Albertino
- Damsgaard Camilla T
- Danaei Goodarz
- Dankner Rachel
- Dantoft Thomas M
- Dasgupta Parasmani
- Dastgiri Saeed
- Dauchet Luc
- Davletov Kairat
- De Backer Guy
- De Bacquer Dirk
- de Gaetano Giovanni
- De Henauw Stefaan
- de León Antonio Cabrera
- de Oliveira Paula Duarte
- de Paiva Karina Mary
- De Ridder David
- De Ridder Karin
- de Rooij Susanne R
- De Smedt Delphine
- de Souza Wanderley Júnior Rildo
- de Wit Tobias F Rinke
- Deepa Mohan
- Deev Alexander D
- Dehghan Abbas
- del Cristo Rodriguez-Perez María
- Delisle Hélène
- Delpeuch Francis
- Demarest Stefaan
- Dennison Elaine
- Dereń Katarzyna
- Deschamps Valérie
- Dhimal Meghnath
- Di Castelnuovo Augusto F
- Di Cesare Mariachiara
- Dias-da-Costa Juvenal Soares
- Diaz Alejandro
- Dika Zivka
- Djalalinia Shirin
- Djordjic Visnja
- do Carmo Franco Maria
- Do Ha TP
- Dobson Annette J
- Donati Maria Benedetta
- Donfrancesco Chiara
- Donoso Silvana P
- Dorobantu Maria
- Dorosty Ahmad Reza
- dos Santos Henrique Rafael
- Doua Kouamelan
- Dragano Nico
- Drygas Wojciech
- Duante Charmaine A
- Duboz Priscilla
- Duda Rosemary B
- Duleva Vesselka
- Dulskiene Virginija
- Dumith Samuel C
- Dushpanova Anar
- Dzerve Vilnis
- Dziankowska-Zaborszczyk Elzbieta
- Díaz-Sánchez María Elena
- Döring Angela
- Eddie Ricky
- Eftekhar Ebrahim
- Egbagbe Eruke E
- Eggertsen Robert
- Eghtesad Sareh
- Ei K Nang Ei
- Eiben Gabriele
- Ekelund Ulf
- El Ati Jalila
- El-Khateeb Mohammad
- Eldemire-Shearer Denise
- Eliasen Marie
- Elliott Paul
- Engle-Stone Reina
- Enguerran Macia
- Erasmus Rajiv T
- Erbel Raimund
- Erem Cihangir
- Eriksen Louise
- Eriksson Johan G
- Eslami Saeid
- Esmaeili Ali
- Evans Alun
- Ezzati Majid
- Faeh David
- Fakhretdinova Albina A
- Fall Caroline H
- Faramarzi Elnaz
- Farjam Mojtaba
- Farzadfar Farshad
- Fattahi Mohammad Reza
- Fawwad Asher
- Felix-Redondo Francisco J
- Ferguson Trevor S
- Fernandes Romulo A
- Fernández-Bergés Daniel
- Ferrante Daniel
- Ferrao Thomas
- Ferrari Marika
- Ferrario Marco M
- Ferreccio Catterina
- Ferrer Eldridge
- Ferrieres Jean
- Figueiró Thamara Hubler
- Fijalkowska Anna
- Filippi Sarah
- Fink Günther
- Fischer Krista
- Foo Leng Huat
- Forsner Maria
- Fouad Heba M
- Francis Damian K
- Frikke-Schmidt Ruth
- Frontera Guillermo
- Fuchs Flavio D
- Fuchs Sandra C
- Fujiati Isti I
- Fujita Yuki
- Fumihiko Matsuda
- Furusawa Takuro
- Gaciong Zbigniew
- Gafencu Mihai
- Galbarczyk Andrzej
- Galenkamp Henrike
- Galeone Daniela
- Galfo Myriam
- Galvano Fabio
- Gao Jingli
- Garba Jamila Abubakar
- Garcia-de-la-Hera Manoli
- García-Solano Marta
- Gareta Dickman
- Garnett Sarah P
- Gaspoz Jean-Michel
- Gasull Magda
- Gaya Adroaldo Cesar Araujo
- Gaya Anelise Reis
- Gazzinelli Andrea
- Gehring Ulrike
- Geiger Harald
- Geleijnse Johanna M
- Ghaffar Suhaila Abdul
- Ghanbari Ali
- Ghasemi Erfan
- Gheorghe-Fronea Oana-Florentina
- Giampaoli Simona
- Gianfagna Francesco
- Gill Tiffany K
- Giovannelli Jonathan
- Gironella Glen
- Giwercman Aleksander
- Gkiouras Konstantinos
- Godos Justyna
- Gogen Sibel
- Goldberg Marcel
- Goldsmith Rebecca A
- Goltzman David
- Gomula Aleksandra
- Gonzalez Angel R
- Gonzalez-Chica David A
- Gonzalez-Gross Marcela
- González-Leon Margot
- González-Rivas Juan P
- González-Villalpando Clicerio
- González-Villalpando María-Elena
- Gonçalves Helen
- Gottrand Frederic
- Graff-Iversen Sidsel
- Grafnetter Dušan
- Grajda Aneta
- Grammatikopoulou Maria G
- Graça Antonio Pedro
- Gregg Edward W
- Gregor Ronald D
- Grodzicki Tomasz
- Grosso Giuseppe
- Gruden Gabriella
- Grøholt Else Karin
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- Zhang Zhen-Yu
- Zhao Dong
- Zhao Ming-Hui
- Zhao Wenhua
- Zhen Shiqi
- Zheng Wei
- Zheng Yingfeng
- Zholdin Bekbolat
- Zhou Bin
- Zhou Maigeng
- Zhu Dan
- Zins Marie
- Zitt Emanuel
- Zocalo Yanina
- Zuziak Monika
- Ängquist Lars
- Łuszczki Edyta
- Ševcíková Ludmila
- Publication venue
- eLife Sciences Publications
- Publication date
- 01/01/2021
- Field of study
From 1985 to 2016, the prevalence of underweight decreased, and that of obesity and severe obesity increased, in most regions, with significant variation in the magnitude of these changes across regions. We investigated how much change in mean body mass index (BMI) explains changes in the prevalence of underweight, obesity, and severe obesity in different regions using data from 2896 population-based studies with 187 million participants. Changes in the prevalence of underweight and total obesity, and to a lesser extent severe obesity, are largely driven by shifts in the distribution of BMI, with smaller contributions from changes in the shape of the distribution. In East and Southeast Asia and sub-Saharan Africa, the underweight tail of the BMI distribution was left behind as the distribution shifted. There is a need for policies that address all forms of malnutrition by making healthy foods accessible and affordable, while restricting unhealthy foods through fiscal and regulatory restrictions
Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries
- Author
- Abad-Motos Ane
- Abbas Ahmed M.
- Abbas Mostafa
- Abbasi Mujeeb
- Abbott Tom
- Abd Karim Muhammad Fairuz Shah
- Abdalaal Ibrahim
- Abdel-Galil Khalid
- Abdelemam Rania
- Abdelgawad Abdalrahman
- Abdelkarim Maryam
- Abdelkhalek Mohamed
- Abdelmageed Abdelfatah
- Abdelmawgoud Sherif
- Abdelmohsen Sarah
- Abdelrahman Ahmed Saber
- Abdelrahman Mostafa
- Abdelwahab Khaled
- Abdou Hossam
- Abdulai Darling Ramatu
- Abdulkhaleq Marwa
- Abdullah Bahiyah
- Abdulsalam Khalifa
- Abdulsalam Shuaib
- Abdur-Rahman Lukman
- Abdus-Salam Rukiyat
- Abdussalam Hameedat Opeyemi
- Abebrese John Tabiri
- Abeldaño Ariel
- Abou-Khalil Jad
- Abou-Taleb Hisham
- Abozid Anwaar
- Abozied Hesham
- Abrate Alberto
- Abu-Zaid Ahmed
- Abubakar Mohammed Kabir
- Abud Burçin
- Abuzaid Mohammed
- Adam Albushra Altayeb
- Adamina Michel
- Adamou Harissou
- Adamu Auwal
- Adamu Kabir Musa
- Adanu Kekeli
- Adebara Idowu
- Adebola Oluwaseyi
- Ademuyiwa Adesoji
- Adeniran Abiodun
- Adepiti Akinfolarin
- Aderogba Adeleke Akeem
- Adesunkanmi Abdulhafiz
- Adeyeye Ademola
- Adisa Adewale
- Adjeso Theophilus Justus Kofi
- Ads Adel Mohamed
- Ads Alaa Mohamed
- Adu-Aryee Nii Armah
- Adumah Collins
- Afzal Irrum
- Agapov Mikhail
- Agarwal Gaurav
- Agarwal Ravi
- Agbeko Anita Eseenam
- Agbeno Evans Kofi
- Agbonrofo Peter
- Agboola Oluseyi
- Aggarwal Gaurav
- Aghadi Ifeanyi
- Aghtarafi Natasha
- Agrawal Amit
- Agresta Ferdinando
- Aguado Héctor J.
- Aguilera-Arevalo Maria-Lorena
- Aherne Thomas
- Ahmad Aline
- Ahmad Maleeha
- Ahmad Misbahu
- Ahmad Sarwat
- Ahmad Shahzaib
- Ahmad Shoaib
- Ahmed Hayat Tarig Abdelhafiz
- Ahmed Khalid
- Ahmed Sharwany
- Ahmed Shima
- Ahmed Usama
- Aisuodionoe-Shadrach Oseremen
- Aitken Sarah
- Ajenifuja Kayode
- Ajiya Abdulrazak
- Akeel Nouf
- Akin Emrah
- Akinajo Opeyemi
- Akinyemi Tosin
- Akrida Ioanna
- Aktokmakyan Talar Vartanoglu
- Akwaisah Ayoub
- Al Bettar Osama
- Al-Badawi Ismail A.
- Al-Juaifari Maytham
- Al-Khyatt Waleed
- Al-Mallah Abdullah
- Al-Nusairi Ahmed
- Al-Saadi Nina
- Al-Sayaghi Khaled
- Al-Shaiji Tariq
- Al-Shehari Mohammed
- Al-Touny Aiman
- Al-Touny Shimaa A.
- Aladawi Omar
- Aladna Abdallah
- Alali Mahmoud
- Alam Mahmood
- Alam Mohammed Shadrul
- Alarabi Rehab
- Alawneh Yazan
- Alayande Barnabas
- Albanese Erminia
- Albayadi Eslam
- Albdour Maram
- Alconchel Felipe
- Alderazi Amer
- Alegbeleye Bamidele
- Alekberli Tural
- Alemu Misganaw Alemu Adimass
- Alexander Philip
- Alfieri Alex
- Algahtany Khaled
- Algarni Kamal
- Alhamad Ameen
- Alhamid Mohammad
- Alharmi Rawan A. Rahman
- Alharthi Mohammed
- Alhazmi Barrag
- Ali Mohamed Shafi Mahboob
- Ali Stephen
- Alibrahim Hidar
- Aljaaly Hattan
- Aljaiuossi Anas
- Aljanadi Firas
- Aljiffry Murad
- Aljirdabi Noof
- Alkahlan Mohammed
- Alkhalifa Elmustafa
- Alkhatib Sondos
- Alkhatieb Maram
- Allan Anna
- Almarshad Felwa
- Almgla Naser
- Almhimid Ali
- Almiqlash Bushray
- Almoshantaf Mohammad Badr
- Almutairi Abdulmjeed
- Alnsour Abed Alfattah Mahmoud
- Alobied Majd
- Alomar Osama
- Alonso Jesús Aarón Martínez
- Alonso Manuel Diez
- Alonso Nestor Fabian Pedraza
- Alonso Veronica
- Alqallaf Abdullah
- Alqaseer Asma
- Alrayes Bourhan
- Alsefri Maryam
- Alser Osaid
- Alsharif Mohammed
- Alsori Mohamed
- Altaf Abdulmalik
- Altinel Yuksel
- Altiner Saygin
- Altouny Ahmad
- Altun Demet
- Alvarez Natalia
- Alvarez-Lozada Luis Adrian
- Alvi Abdul
- Alwael Athari
- Alwash Mohammed
- Alyami Ziyad
- Alyousef Mohammed
- Alzahrani Saud
- Alzerwi Nasser
- Amin Shivang
- Amir Mohammed
- Ammar Ahmed Siddique
- Ammendola Michele
- Amores Remedios Revilla
- Amrayev Sultan
- Anastasiadou Sofia
- Ancans Guntis
- Anderson Caroline
- Andreani Lorenzo
- Andreotti Dario
- Andreuccetti Jacopo
- Andrianakis Alexandros
- Andro Christophe
- Anesi Alexandre
- Angamuthu Stephen
- Angeles Martina Aida
- Angelico Roberta
- Angelis Fragkiskos
- Angelou Dimitrios
- Angelou Kyveli
- Angulo Victor Pinto
- Anjum Arfa
- Anjum Muhammad Ayyub
- Annicchiarico Alfredo
- Anoldo Pietro
- Ansaloni Luca
- Anthoulakis Christos
- Antonelli Amedeo
- Anwar Mohamed
- Anwar Sumadi Lukman
- Anwer Mariyah
- Anyanwu Lofty-John
- Apostolou Christos
- Apostolou Konstantinos
- Appiah-Kubi Adu
- Aprea Giovanni
- Arbab Hana
- Archer James
- Ardura Francisco
- Aremu Muyiwa
- Arif Tahera
- Arkani Samara
- Armatura Giulia
- Armijos Daniel
- Arnaout Ali
- Arnaoutoglou Eleni
- Arnaud Alexis P.
- Arneja Jugpal
- Arrangoiz Rodrigo
- Arshad Muhammad
- Arthur Joshua
- Ashcroft James
- Ashford Bruce
- Ashraf Fariha
- Asiimwe Daniel
- Asirifi Samuel Amoako
- Asla Amir
- Aslam Ramisha
- Aspide Raffaele
- Ataya Karim
- Ateca Ibabe Villalabeitia
- Atici Semra Demirli
- Atis Gokhan
- Atkins William
- Atkinson Kate
- Attwood Joseph
- Auerkari Aino
- Augestad Knut Magne
- Augustin Goran
- Aujayeb Avinash
- Avella Pasquale
- Awad Ahmed K.
- Awad Hadeel
- Awad Rabih
- Awad Selmy
- Ayad Kusay
- Ayana Birhanu
- Aydin Yener
- Ayeni Funbi
- Aytac Erman
- Azab Ahmed
- Azami Rizwan
- Azize Diallo Abdoul
- Azzam Ahmed Y.
- Azzis Olivier
- Baba Yabasin Iddrisu
- Babis George
- Bacalbasa Nicolae
- Badiani Sarit
- Badran Saif
- Baduell Albert
- Baeesa Saleh
- Baertschiger Reto
- Bafaquh Mohammed
- Bahassan Omar Mohammed
- Bahrami-Hessari Michael
- Baia Marco
- Baidoo Ebikela Ivie
- Bailey Karen
- Baili Efstratia
- Bains Lovenish
- Baiocchi Gian Luca
- Baiocchi Glauco
- Baiyewu Lateef Ayodele
- Bajaj Ankur
- Bajunaid Khalid
- Balagobi Balasingam
- Balasubramanian Ishwarya
- Balduzzi Alberto
- Baldwin Alexander
- Balla Andrea
- Balogh Zsolt J.
- Balogun James A.
- Balogun Simon
- Baloyiannis Ioannis
- Ban Vin Shen
- Bandyopadhyay Samik Kumar
- Bandyopadhyay Soham
- Banerjee Sumit
- Banipal Gurpreet Singh
- Banky Balazs
- Bannone Elisa
- Bansal Sujesh
- Barberis Andrea
- Barbosa-Breda Joao
- Bareka Metaxia
- Barišić Tatjana
- Barlas Aziz Mutlu
- Barlow Ciaran
- Barmayehvar Behrad
- Baroffio Paolo
- Barone Mirko
- Barra Fabio
- Barranquero Alberto G.
- Barugola Giuliano
- Basendowah Mohammed
- Bashir Mahmod
- Basnayake Oshan
- Bass Gary Alan
- Basu Somprakas
- Bateman Antony
- Bateman Kellie
- Batista Sylvia
- Batstone Martin
- Bauer Marlies
- Bauset Juan Carlos Catalá
- Bawa Ashvind
- Bawa Sayesha
- Bayhan Hüseyin
- Bayo Heura Llaquet
- Bazzi Nagham
- Beamish Andrew
- Beasley Nigel
- Beatty Jasmine Winter
- Becerra Angel
- Bedada Alemayehu Ginbo
- Bedzhanyan Arkady
- Begum Farzana
- Beisenov Bekzat
- Bellio Gabriele
- Bello Usman Mohammed
- Bellés Ana Ciscar
- Belzile Etienne
- Benamar Safia
- Bence Matthew
- Benshetrit Guy
- Bensoltane Khadidja
- Bergkvist David Julià
- Beristain-Hernandez Jose-Luis
- Bernante Paolo
- Bernardi Daniele
- Beron Reinaldo Isaacs
- Berselli Bruno
- Berselli Mattia
- Bertelli Giacomo
- Bertoglio Pietro
- Bertolaccini Luca
- Beswick Daniel
- Bette Birgit
- Bezirci Rifat
- Bhangu Aneel
- Bharathan Rasiah
- Bhat Vivek
- Bhatti Khalid
- Bianchi Valentina
- Bianco Francesco
- Bianco Giuseppe
- Bijou Walid
- Bilfaqirah Majed
- Biloslavo Alan
- Bin Alhassan Baba Alhaji
- Binnawara Muhannud
- Bissacco Daniele
- BİŞGİN TAYFUN
- Blair James
- Blanco Jose
- Blencowe Natalie
- Bloemers Frank
- Board Timothy
- Bobak Peter
- Boccalatte Luis
- Boedo Maria Jesus Maroño
- Bohmer Rob
- Boira Mar Achalandabaso
- Boisson Matthieu
- Boligo Sofia
- Bolton William
- Bombardini Cristina
- Bonavina Luigi
- Bonci Eduard-Alexandru
- Bondurri Andrea
- Bonilla Antonio Ramos
- Bonsaana Gilbert Batieka
- Booth L.
- Borg Elaine
- Borges Miguel Fróis
- Borges Nuno
- Bork Ulrich
- Borselle Dominika
- Bortul Marina
- Botelho Pedro
- Bottari Andrea
- Bouchagier Konstantinos
- Bouliaris Konstantinos
- Bowan Antoinette Bediako
- Bowen Joel
- Bozbiyik Osman
- Bracale Umberto
- Brachini Gioia
- Bramis Konstantinos
- Branagan Graham
- Branzan Daniela
- Brasset Camille
- Bratus Dejan
- Bravo Ana Maria Minaya
- Bravo Sybil Lizanne
- Bright Tim
- Brisinda Giuseppe
- Brodkin Edgar
- Broglia Alessandro
- Brolese Alberto
- Browning Rebecca
- Bruzzaniti Placido
- Brzeszczyński Filip
- Bsisu Isam
- Bua Emmanuel
- Budd Gabrielle
- Bukhari Syed Imran
- Bulian Dirk Rolf
- Bumbasirevic Uros
- Bumber Boris
- Burgos-Blasco Barbara
- Burlov Nikita
- Bussu Francesco
- Bàmbina Fabrizio
- Börner Nikolaus
- Böttcher Arne
- Cabeza Leticia
- Cabrera Marino
- Cais Simon
- Cakmak Guldeniz Karadeniz
- Calabretto Francesca
- Calabrò Marcello
- Calavia Pablo
- Calculli Federica
- Calini Giacomo
- Callan Rory
- Callcut Rachael
- Calu Valentin
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- Calvache Nieto
- Calvo Francisco Javier Redondo
- Cama Jitoko
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- Camargo-Parra Katherin
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- Cammarata Francesco
- Cammarata Roberto
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- Campennì Paola
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- Campuzano Nicolas
- Cano-Trigueros Emiliano
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- Capobianco Mattia
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- Capozzi Enrico
- Cappuccio Micaela
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- Carretero Manuel Moriche
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- Carvello Michele
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- Castaño Mario
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- Christodoulou Prokopis
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- Cohnert Tina
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- Cokan Andrej
- Colak Elif
- Colasanti Roberto
- Cole Simon
- Collins Michelle L.
- Colombari Renan Carlo
- Colombo Francesco
- Colucci Nicola
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- Conso Christel
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- Conti Luigi
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- Cotovio Manuel Damasio
- Coughlin Patrick
- Cox Daniel
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- Creavin Ben
- Crichton Robert
- Critchley Rebecca
- Croghan Stefanie M.
- Cross George W. V.
- Cruz Ricardo Pedrini
- Cucinella Giuseppe
- Cullinane Carolyn
- Cullis Paul
- Cunha Miguel F.
- Cunningham Brian
- Currò Giuseppe
- Cuthbert Rory
- Cutmore Carina
- Czako Ladislav
- Cáceres Freud
- D'Acapito Fabrizio
- D'Addino José Luis
- D'Amico Alessia
- D'Amore Anna
- D'Andrea Giancarlo
- D'Archi Sabatino
- D'Oria Mario
- D'Sa Prashanth
- Daddi Niccolo'
- Dagklis Themistoklis
- Dajani Khaled
- Dajti Irida
- Daketsey Elorm
- Daley Brian
- Dare Anna
- Daruwalla Jurstine
- Das Sunit
- Dasa Michael
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- Davidescu Mihnea
- Davies Jessica
- Davies Mark
- Davies Richard Justin
- Davis Amelia
- Dawson Amanda Caroline
- Dawson Jonathon
- Dbouk Samer
- De Alarcón Jaime Rodríguez
- De Andrés-Asenjo Beatriz
- De Bacco Marangon Gustavo
- De Campos Prado Caio Antonio
- De Cillia Michael
- De Haro Jorge Irene
- De Haro Joaquin
- De Jesus Labrador Hernandez Gregorio
- De La Infiesta García Carlos
- De La Medina Antonio Ramos
- De La Rosa-Estadella Marta
- De Nardi Paola
- De Oliveira Gabriel Paiva
- De Pastena Matteo
- De Simone Veronica
- De Sousa Álvaro Francisco Lopes
- De Vega Sánchez Blanca
- De Virgilio Armando
- De Zuanni Marco
- Dean Yomna
- Degarege Dawit
- Degener Stephan
- Dejeu George
- Del Amo María Dolores Arribas
- Dell Angela
- Demetrashvili Zaza
- Demetriades Andreas K
- Demetriou Charis
- Demir Sebahattin
- Dennis Rory
- Deputy Mohammed
- Derilo Habtamu
- Des Déserts Marc Danguy
- Desai Chaitya
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- Dewan Michael
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- Di Bartolomeo Mattia
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- Diaconescu Bogdan
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- Dindyal Shiva
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- Djedovic Gabriel
- Doerner Johannes
- Doherty Daniel
- Dolci Giampiero
- Domanin Maurizio
- Domingo Marta María Arroyo
- Dominguez-Rosado Ismael
- Don Cristine Pathirannehalage
- Donkin Ian
- Donmez Emin Erhan
- Donoghue Sophie
- Donovan Richard
- Dornseifer Mamun David
- Dorovinis Panagiotis
- Douglas Deborah
- Downey Candice
- Doyle Alex
- Doǧan Lütfi
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- Dzhumabaev Khasan
- Dziakova Jana
- Dzogbefia Mawutor
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- Dölker Theresa
- Eardley Nicola
- Ebrahim Abdulla
- Echieh Chidiebere Peter
- Edwards John
- Efetov Sergey
- Efremov Sergey
- Egan Richard
- Eiras Miguel Angel Freiria
- Eisa Elamin
- Ekor Oluwayemisi
- Ekwen Gerald
- Ekwunife Okechukwu Hyginus
- El Assaad Hadi
- El Boghdady Michael
- El Tayeb Essam Eldien Abuobaida Banaga Hag
- El-Boghdadly Kariem
- El-Hussuna Alaa
- El-Kassas Mohamed
- Elagili Ahmed
- Elahi Zain
- Elbadawy Merihan A.
- Elbahnasawy Mohamed
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- Elboraei Rahma
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- Elfeki Hossam
- Elfiky Mahmoud
- Elgazar Amr
- Elghadban Hosam
- Elhadi Muhammed
- Elhassan Wael Atif Fadl
- Elkazaz Ahmed
- Ellafi Amera Ali Dakheel
- Elliot R.
- Elnour Moheyaldien Ahmed Elamin
- Elsadek Menan
- Elsahli Saifaleslam
- Elsalhawy Shady
- Elsayem Karam
- Elshahawy Mahmoud Abdelaziz Mohamed
- Elsherbiny Ahmed
- Eltayeb Momin
- Elzwai Suha
- Emara Moataz Maher
- Embarek Hussein
- Emile Sameh
- Emmanuel Muhawenimana
- Enciu Octavian
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- Enodien Bassey
- Enwerem Kenneth
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- Erginöz Ergin
- Eroglu Atilla
- Escobar Pedro
- Escobedo Francisco Jose Barbosa
- Escrevente Ricardo
- Eskinazi Diego
- Esposito Sofia
- Eugene Muneza
- Ezanno Anne-Cecile
- Ezeanochie Michael
- Ezeme Constantine
- Ezenwa Ekene
- Ezomike Uchechukwu
- Fadalla Tarig
- Fadel Zahir T
- Fahim Margo Medhat Fouad
- Fahmy Ali
- Faiz Javaria
- Fajardo Rafael Torres
- Fakhradiyev Ildar
- Fallah Jean-Michel
- Familiari Pietro
- Fang Clarissa Ern Hui
- Faponle Folayemi
- Farhan-Alanie Muhamed
- Farid Shahzaib
- Farooq Muhammad
- Fatima Mishal
- Fayad Elsayed A.
- Federer Simon
- Federico Nicoletta Sveva Pipitone
- Feeney Kaylem
- Fehervari Matyas
- Fekaj Enver
- Fernandez Laura Gomez
- Fernández Julio Domenech
- Ferracci Federica
- Ferrara Francesco
- Ferrari Davide
- Ferrario Luca
- Ferreli Fabio
- Ferrer Antonio Perez
- Ferrer Ursula María Jariod
- Festa Bianca Maria
- Fiacchini Giacomo
- Figus Andrea
- Filipescu Daniela
- Fiore Marco
- Fiorelli Silvia
- Fitzgerald Conall
- Fleming Christina
- Fleming Fergal
- Fleres Francesco
- Flis Vojko
- Flores S.L.
- Florian Ioan-Alexandru
- Flumignan Carolina Dutra Queiroz
- Flumignan Ronald
- Flórez Luis Joaquín García
- Foessleitner Philipp
- Fontalis Andreas
- Forde Cillian
- Forneris Agustin Albani
- Fortuna Laura
- Fowler George
- Fozo Khaldoun
- Fragoso Marta
- Franceschini Gianluca
- Frankel Adam
- Fransvea Pietro
- Franza Mara
- Fraser Sheila
- Frasson Matteo
- Frisoni Tommaso
- Frolova Yulia
- Frontali Alice
- Frountzas Maximos
- Fruscio Robert
- Fujimoto Yuki
- Furey Joseph
- Fusario Daniele
- Fusini Federico
- Futaba Kaori
- Függer Reinhold
- Gabr Abdullah
- Gada Parth
- Gadelkareem Rabea
- Gafsi Besma
- Gahlot Nitesh
- Gahwagi Milad
- Gaino Francesca
- Galandarov Vagif
- Galandarova Aysuna
- Gallagher Brendan
- Galliard Katherine
- Gallo Oreste
- Galvan Armando
- Gananadha Sivakumar
- Garas George
- Garcia Carolina Soledad Romero
- Garcia Sean
- Garcia-Virto Virginia
- García Lucia Diego
- García Pablo Rodríguez
- García-Conde María
- Gareb Fahed
- Garg Pankaj Kumar
- Garod Mebanshanbor
- Garoufalia Zoe
- Garzali Ibrahim Umar
- Gasparini Giulio
- Gass Jörn-Markus
- Gatta Anna Nunzia Della
- Gatti Arthur
- Gawron Iwona Magdalena
- Gebremeskel Zersenay
- Gefen Rachel
- George Christina
- Gero Daniel
- Gerogiannis Ioannis
- Gessler Florian
- Ghalleb Montassar
- Ghannam Abdelilah
- Gharat Mayur
- Ghazal Ahmad
- Ghobrial Marios
- Ghodke Rahul
- Ghosh Dhruv
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- Nasser Sara
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- Rokohl Alexander Christopher
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- Su Yu-Xiong
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- Subramani Yamini
- Subramaniam Sentilnathan
- Sue-Chue-Lam Colin
- Suer Muhammed Salih
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- Sultania Mahesh
- Sundarraju Shalini
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- Yanowsky-Reyes Guillermo
- Yassin Abubaker
- Yates Elizabeth
- Yebes Alvaro
- Yenli Edwin Mwintiereh Ta-Ang
- Yeoh Tien
- Yeung Justin
- Yiallourou Anneza
- Yigit Banu
- Yildirim Asif
- Yim Guang
- Yiu Andrew
- Yonekura Hiroshi
- Yotsov Tsanko
- Younis Muhammad Umar
- Yunus Alif
- Yusefi Hossein
- Zabaleta Jon
- Zabkiewicz Catheriner
- Zaccaria Giulia
- Zacharia Bincy
- Zafar Syed Nabeel
- Zago Mauro
- Zaheen Zakia
- Zahid Zahra
- Zaimis Tilemachos
- Zakaria Andee Dzulkarnaen
- Zambon Martina
- Zamora Lindsey
- Zampogna Biagio
- Zancana Giuseppa
- Zani Augusto
- Zanin Luca
- Zanini Nicola
- Zapardiel Ignacio
- Zapata Carlos Shiraishi
- Zarif Pierre
- Zaránd Attila
- Zehnder Philipp
- Zenger Serkan
- Zenha Horácio
- Zhu Michael Z. L.
- Ziemann Sebastian
- Zimak Danijela Mrazovac
- Zimak Zoran
- Zivkovic Dragana
- Zizzo Maurizio
- Zucker Benjamin
- Zwain Yasir
- Zyskowski Michael
- Ávila Clara Castro
- Älgå Andreas
- Çakici Mehmet Çaǧlar
- Çelik Enes
- Çelik Meryem Nur
- Özçay Necdet
- Şevik Hüsnü
- Šantak Goran
- Šimko Kristián
- Žatecký Jan
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2023
- Field of study
Abstract
Background
Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres.
Methods
This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries.
Results
In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia.
Conclusion
This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries
Todo sabe mejor con ciencia
- Publication venue
- Publication date
- 27/09/2018
- Field of study
Notas. Ciencias biológicasLos experimentos permitieron explorar la cocina como laboratorio, haciendo que los cocineros, en un intento por mejorar sus recetas y crear nuevas texturas y sabores, empezaran a aplicar los principios físicoquímicos implicados en la cocina y el equipamiento mismo del laboratorio en sus receta