18 research outputs found
Adomian Decomposition Method for Solving Coupled KdV Equations
- Author
- Publication venue
- 'CIRWOLRD'
- Publication date
- 01/05/2015
- Field of study
In this article, we study a numerical solution of the coupled kdv equation with initial condition by the Adomian Decomposition Method.The solution is calculated in the form of aconvergent power series with easily computable components. Numerical results obtained by this method have been compared with the exact solution to show that the Adomian Decomposition method is a powerful method for the solution of coupled kdv equation
Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries
- Author
- Aamir Faiqa Binte
- Aamir Syed Roohan
- Ababneh Adnan
- Abbal Muhammad Anas
- Abbas Ahmed M
- Abbas Mostafa
- Abd-Albain Montasir A
- Abdalei Abdulwahab
- Abdalla Ahmed
- Abdalla Ahmed Yassir
- Abdalla Mohamed Galal Ali
- Abdalla Zainab
- Abdallah Mohamed M
- Abdalmahmoud Noon Ezzeldien
- Abdalsadeg Rowa
- Abdelaal Ahmed M
- Abdelbagi Alnazeer Y
- Abdelbaky Mostafa
- Abdelbaset Doaa
- AbdElbaset Esraa
- Abdelbast Menhag
- Abdelfatah Mohammed Abdelnasser
- Abdelgawad Samia
- Abdelhamid Mohamed M
- Abdeljaber Mahmoud
- Abdelkhalig Mubarak
- Abdelmaksoud Mohamed
- Abdelmeguid Rana
- Abdelmelek Dhia Errahmane
- Abdelnaeam Samah
- Abdelnasser Mohammad K
- Abdelrahim Najwa
- Abdelrahman Amira
- Abdelrahman Ayman
- Abdelsalam Hebatalla
- Abdelsamed Enas Abdelbaset
- Abdelwahab Khaled
- Abdoun Meriem
- Abdulali Fatima
- Abdulaziz Mohamed
- Abdulla Dheba Almukhtar
- Abdullah Bahiyah
- Abdullah Bahiyah
- Abdullah Walaa
- Abdullahi Habiba Ibrahim
- Abdulrahman Ahmed
- Abdulrasheed Lubabatu
- Abdulwahed Eman
- Abdulwahed Eman
- Abeysirigunawardana Dewmi
- Abidin Muhammad Fihmi Zainal
- Abiola Olukayode
- Abiyere Henry
- Abodina Ahmed Mohammed
- Aboelela Reham
- AboElfarh Hadeer Elsaeed
- Aboudlal Husein
- AbouHiekal Osama
- Aboulfotouh Ahmed
- Abozid Anwaar
- Abubaker Noora
- Abubaker Noora
- Abufanas Asma
- Abughanima Mahmoud
- Abuhashem Shehab
- Abulafia Daniel
- Abushaala Fatima
- Abushanab Khaled
- AbuShawareb Issa
- Abuuqteish Hamza
- Abuzaho Amany
- Achem Arome
- Adam Eithar
- Adam Mohammed
- Adam Mohammed A
- Addalla Mohamed
- Addley Jordan
- Adeleye Gbadebo
- Adeniyi Adebayo
- Adewole Nathaniel
- Adeyemo Olabisi
- Adeyeye Ademola
- Adeyeye Ademola
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- Ads Alaa Mohamed
- Adze Joel Amwe
- Afeikhena Ehis
- Agida Teddy
- Agilla Hamza
- Agnew Emilie
- Agu Joy Onyekachi
- Ahmad Zatul Akmar
- Ahmed Abdalla
- Ahmed Ahmed
- Ahmed Ahmed
- Ahmed Alaaaldeen
- Ahmed Entisar
- Ahmed Habeeba
- Ahmed Hatem
- Ahmed Reem
- Ahmed Rehab
- Ahmed Rihab
- Ahmed Rogia Ahmed Abdalla
- Ahmed Ruaa
- Ahmed Sharwany
- Ahmed Uzair
- Ahmed Wahiba
- Ahmeed Sultan
- Airede Lydia Regina
- Aitchison Lori
- Ajredini Mirac
- Ajulo Adeshina A
- Akaba Godwin
- Akasha Mazin
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- Al-Issawi Subhi
- Al-jammal Maryam
- Al-Juaifari Maytham A
- Al-Mwajeh Tesneem
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- Al-Quossi Mohammed
- Al-Shambaty Yasir Babkir Ali
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- Yuzgec Ayse Nilufer
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- Zaed Moahmed
- Zafar Fatima
- Zaghloul Ahmed
- Zaheer Adil
- Zaidi Faseeh
- Zain Ahmad
- Zakaria Ahmed
- Zakaria Andee Dzulkarnaen
- Zakaria Mohd Zaim
- Zalloum Jihad
- Zamanbandhon Bushra
- Zambon Mattia
- Zapsalis Konstantinos
- Zargar Kamran
- Zarzour Mohamed A
- Zeng Raymond
- Zeng Raymond
- Zengin Kagan
- Zertuche Juventino Tadeo Guerrero
- Zhang Caitlin
- Zhang Edward
- Zhang Shane
- Zhang Yichi
- Zhao Hailin
- Zheng Helen
- Zhou Karen
- Zhou Yida
- Ziergiebel Felix
- Zou Peishan
- Zuylekom Kate Van
- Zuylekom Katie Van
- Zwain Yasir Adnan
- Zyul'korneeva Sof'ya
- Aladna Abdallah
- Aljoumaa Abdullah
- Nawfal Hamdi
- Niazi Ammar
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely
Characterization of greater middle eastern genetic variation for enhanced disease gene discovery
- Author
- Abdel Hadi Sawsan
- Abdel Salam Ekram
- Abdel Salam Ghada
- Abdou Mohammed
- Abel Laurent
- Abhytankar Avinash
- Adimi Parisa
- Ahmad Jamil
- Akcakus Mustafa
- Aksu Guside
- Al Aama Jumana
- Al Allawi Nasir
- Al Baradie Raidah
- Al Gazali Lihadh
- Al Hajjar Sami
- Al Hashem Amal
- Al Herz Waleed
- Al Jeaid Deema
- Al Juamaah Suliman
- Al Muhsen Saleh
- Al Sannaa Nouriya
- Al Tameni Salem
- Al Tawari Asma
- Alangari Abdullah
- Alcais Alexandre
- Alfawaz Tariq S.
- Alsediq Najla Sameer
- Alsum Zobaida
- Ammar Khodja Aomar
- Amouian Sepideh
- Arikan Cigdem
- Aryani Omid
- Aslanger Ayca
- Aydogmus Cigdem
- Aytekin Caner
- Azab Mostafa Abdellateef
- Azam Matloob
- Bansagi Boglarka
- Barbouche Mohamed Rhida
- Bastaki Laila
- Belkadi Aziz
- Ben Omran Tawfeg
- Bindu Parayil Sankaran
- Blancas Lizbeth
- Boisson Dupuis Stéphanie
- Boisson Bertrand
- Bonnet Damien
- Bousfiha Aziz
- Boussafara Lobna
- Boutros Jeannette
- Bustamante Jacinta
- Caksen Huseyin
- Camcioglu Yildiz
- Catherinot Emilie
- Celik Fatma C.
- Ciancanelli Michael
- Cipe Funda E.
- Clark Andrew G.
- Clark Gary
- Cobat Aurélie
- Comu Sinan
- Condie Angela
- Condino Neto Antonio
- Desai Mukesh
- Dobyns William
- Dogu Figen
- Domaia Mohamed
- Dorum Meltem
- Egritas Odul
- El Azbaoui Safa
- El Baghdadi Jamila
- El Harouni Ashraf
- El Ruby Mona
- Elfeky Reem A.
- Elghazali Gehad
- Faqeih Eissa
- Fenerci Elif
- Fieschi Claire
- Funda Cipe
- Gabriel Stacey B.
- Gamal Iman
- Gelik Umit
- Genel Fetah
- Gezdirici Alper
- Girisha Katta M.
- Goldstein Amy
- Grattan Smith Padraic
- Gupta Neerja
- Hahn Jin
- Halees Anason
- Hatipoglu Nevin
- He Yupeng
- Hennekam Raoul
- Houshmand Massoud
- Ichai Philippe
- Ikinciogullari Aydan
- Ismail Samira
- Itan Yuval
- Jalas Chaim
- Jouanguy Emmanuelle
- Kabra Madhulika
- Kalkan Göknur
- Kara Majdi
- Karaca Neslihan
- Karaer Kadri
- Kariminejad Ariana
- Kayserili Hulya
- Keser Emiroglu Melike
- Kilic Sara S.
- Kissani Najib
- Koc Zeynep Peker
- Kokron Cristina
- Koul Roshan
- Kutukculer Necil
- Lanternier Fanny
- Mahdaviani Alireza
- Mahlaoui Nizar
- Mansour Lobna
- Mansouri Davood
- MARGARI Lucia
- Marzouki Naima
- Masri Amira
- Megahed Amina
- Megahed Hisham
- Mekki Najla
- Mesdaghi Mehrnaz
- Mikati Mohd
- Mojahedi Faezeh
- Mulley John
- Nampoothiri Sheela
- Navarrete Carmen
- Omar Tarek
- Oraby Azza
- Pandaluz Ayse
- Parvaneh Nima
- Patiroglu Turkan
- Pellier Isabelle
- Picard Capucine
- Puel Anne
- Raas Rothschild Annick
- Rahim Sohair Abdel
- Rajab Anna
- Raoult Didier
- Reisli Ismail
- Rezaei Nima
- Sabri Ayoub
- Sahin Yasin
- Saleem Laila
- Salem Fadia
- Sanal Ozden
- Sanger Terry
- Scott Eric M.
- Shakankiry Hanan
- Shang Lei
- Shehata Nabil
- Shembesh Nuri
- Shkalim Vared
- Softah Ameen
- Sogaty Sameera
- Soliman Neveen
- Sonmez Aunaci Fatma
- Spencer Emily G.
- Stambouli Omar Boudghene
- Sztriha Laszlo
- Taibi Berrah Lynda
- Temtamy Samia
- Tonekaboni Hasan
- Trauner Doris
- Tuysuz Beyhan
- Valente Enza Maria
- Varan Ali
- Vogt Guillaume
- Walsh Christopher
- Woods Geoffrey
- Yesil Gozde
- Yildiran Alisan
- Yildiz Basak
- Yuksel Adnan
- Zaki Maha
- Zhang Shen Ying
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
The Greater Middle East (GME) has been a central hub of human migration and population admixture. The tradition of consanguinity, variably practiced in the Persian Gulf region, North Africa, and Central Asia1-3, has resulted in an elevated burden of recessive disease4. Here we generated a whole-exome GME variome from 1,111 unrelated subjects. We detected substantial diversity and admixture in continental and subregional populations, corresponding to several ancient founder populations with little evidence of bottlenecks. Measured consanguinity rates were an order of magnitude above those in other sampled populations, and the GME population exhibited an increased burden of runs of homozygosity (ROHs) but showed no evidence for reduced burden of deleterious variation due to classically theorized ‘genetic purging’. Applying this database to unsolved recessive conditions in the GME population reduced the number of potential disease-causing variants by four- to sevenfold. These results show variegated genetic architecture in GME populations and support future human genetic discoveries in Mendelian and population genetics
Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017
- Author
- Abbasalizad-Farhangi Mahdieh
- Abbasi Masoumeh
- Abbastabar Hedayat
- Abdelalim Ahmed
- Abdoli Amir
- Abdollahi Mohammad
- Abdollahpour Ibrahim
- Abdulkader Rizwan Suliankatchi
- Abebe Nebiyu Dereje
- Abebo Teshome Abuka
- Abegaz Kedir Hussein
- Abolhassani Hassan
- Abreu Lucas Guimarães
- Abrigo Michael R. M.
- Abushouk Abdelrahman I.
- Accrombessi Manfred Mario Kokou
- Acharya Dilaram
- Adabi Maryam
- Adebiyi Akindele Olupelumi
- Adedeji Isaac Akinkunmi
- Adekanmbi Victor
- Adema Bereket Duko
- Adeoye Abiodun Moshood
- Adetokunboh Olatunji O.
- Adham Davoud
- Aduroja Posi Emmanuel
- Advani Shailesh M.
- Afarideh Mohsen
- Afshin Ashkan
- Aghaali Mohammad
- Agrawal Anurag
- Ahmad Tauseef
- Ahmadi Keivan
- Ahmadi Sepideh
- Ahmed Muktar Beshir
- Ahmed Rushdia
- Ajumobi Olufemi
- Akal Chalachew Genet
- Akalu Temesgen Yihunie
- Akinyemiju Tomi
- Akombi Blessing
- Al-Aly Ziyad
- Al-Mekhlafi Hesham M.
- Al-Raddadi Rajaa M.
- Alam Samiah
- Alamene Genet Melak
- Alanzi Turki M.
- Alema Niguse Meles
- Ali Beriwan Abdulqadir
- Ali Muhammad
- Alijanzadeh Mehran
- Alinia Cyrus
- Alipour Vahid
- Alizade Hesam
- Aljunid Syed Mohamed
- Almasi Afshin
- Almasi-Hashiani Amir
- Altirkawi Khalid
- Alvis-Guzman Nelson
- Alvis-Zakzuk Nelson J.
- Amare Azmeraw T.
- Amegah Adeladza Kofi
- Amini Saeed
- Amiri Fatemeh
- Amit Arianna Maever Loreche
- Anber Nahla Hamed
- Andrei Catalina Liliana
- Ansari Fereshteh
- Ansari-Moghaddam Alireza
- Anteneh Zelalem Alamrew
- Antonio Carl Abelardo T.
- Antriyandarti Ernoiz
- Anvari Davood
- Anwer Razique
- Appiah Seth Christopher Yaw
- Arab-Zozani Morteza
- Arabloo Jalal
- Araya Ephrem Mebrahtu
- Arefi Zohreh
- Aremu Olatunde
- Arnedo Carlos Alberto Marrugo
- Arzani Afsaneh
- Asadi-Aliabadi Mehran
- Asadi-Pooya Ali A.
- Asante Kwaku Oppong
- Asgari Samaneh
- Asghari Babak
- Ashagre Alebachew Fasil
- Asrat Anemaw A.
- Ataeinia Bahar
- Atalay Hagos Tasew
- Atnafu Desta Debalkie
- Atout Maha Moh’d Wahbi
- Ausloos Marcel
- Avokpaho Euripide F. G. A.
- Awasthi Ashish
- Ayanore Martin Amogre
- Aynalem Yared A. Asmare
- Azadmehr Abbas
- Azari Samad
- Azarian Ghasem
- Azene Zelalem Nigussie
- Babaee Ebrahim
- Badawi Alaa
- Badiye Ashish D.
- Bahrami Mohamad Amin
- Baig Atif Amin A.
- Bakhtiari Ahad
- Bakkannavar Shankar M.
- Balakrishnan Senthilkumar
- Balalami Nader Jafari
- Bali Ayele Geleto
- Banach Maciej
- Banik Palash Chandra
- Baradaran-Seyed Zahra
- Baraki Adhanom Gebreegziabher
- Barboza Miguel A.
- Barua Lingkan
- Basaleem Huda
- Basu Sanjay
- Bayati Mohsen
- Bayih Mulat Tirfie
- Baynes Habtamu Wondifraw
- Bedi Neeraj
- Behzadifar Masoud
- Behzadifar Meysam
- Bekele Yibeltal Alemu
- Bennett Derrick A.
- Berbada Dessalegn Ajema
- Berhe Abadi Kidanemariam
- Berhe Kidanemaryam
- Berman Adam E.
- Bernstein Robert S.
- Bhageerathy Reshmi
- Bhandari Dinesh
- Bharadwaj Pankaj
- Bhattacharjee Natalia V.
- Bhattacharyya Krittika
- Bijani Ali
- Bikbov Boris
- Bilano Ver
- Bililign Nigus
- Birara Setognal
- Birhane Minuye Biniam Biniam
- Birhanu Minyichil
- Biswas Raaj Kishore
- Bitew Zebenay Workneh
- Bogale Kassawmar Angaw
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- Bolla Srinivasa Rao
- Boloor Archith
- Borzouei Shiva
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- Brady Oliver J.
- Bragazzi Nicola Luigi
- Braithwaite Dejana
- Briko Nikolay Ivanovich
- Britton Gabrielle
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- Busse Reinhard
- Butt Zahid A.
- Bärnighausen Till Winfried
- Cahuana-Hurtado Lucero
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- Cano Jorge
- Car Josip
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- Carvalho Félix
- Castaldelli-Maia João Mauricio
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- Castro Franz
- Cerin Ester
- Chansa Collins
- Charan Jaykaran
- Chatterjee Pranab
- Chattu Vijay Kumar
- Chauhan Bal Govind
- Chavshin Ali Reza
- Chehrazi Mohammad
- Chichiabellu Tesfaye Yitna
- Chin Ken Lee
- Christopher Devasahayam J.
- Chu Dinh-Toi
- Cicuttini Flavia M.
- Collison Michael L.
- Cork Michael A.
- Cormier Natalie
- Cortesi Paolo Angelo
- Costa Vera M.
- Cousin Ewerton
- Cámera Luis Alberto
- Cárdenas Rosario
- Dadi Abel Fekadu Fekadu
- Dagnew Baye
- Dahlawi Saad M. A.
- Damiani Giovanni
- Darwesh Aso Mohammad
- Darwish Amira Hamed
- Daryani Ahmad
- Das Jai K.
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- Demeke Feleke Mekonnen
- Demis Asmamaw Bizuneh
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- Denova-Gutiérrez Edgar
- Deribe Kebede
- Desai Rupak
- Desalegn Beruk Berhanu
- Desalew Assefa
- Deshpande Aniruddha
- Dey Sagnik
- Dharmaratne Samath Dhamminda
- Dhillon Preeti
- Dhimal Meghnath
- Dhungana Govinda Prasad
- Diaz Daniel
- Dinsa Girmaye Deye
- Dipeolu Isaac Oluwafemi
- Djalalinia Shirin
- Do Hoa Thi
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- Doku Paul Narh
- Dorostkar Fariba
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- Durães Andre R.
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- Earl Lucas
- Eftekhari Aziz
- El Razek Hassan Magdy Abd
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- El Sayed Zaki Maysaa
- El Sayed Iman
- El Tantawi Maha
- El-Jaafary Shaimaa I.
- El-Khatib Ziad
- El-Sherbiny Yasser Mohamed
- Elbarazi Iffat
- Elemineh Demelash Abewa
- Elsharkawy Aisha
- Elyazar Iqbal R. F.
- Emamian Mohammad Hassan
- Enany Shymaa
- Endalew Daniel Adane
- Endalifer Melese Linger
- Eskandari Khalil
- Eskandarieh Sharareh
- Esmaeilnejad Saman
- Esteghamati Alireza
- Etemadi Arash
- Etisso Atkilt Esaiyas
- Fanzo Jessica
- Farahmand Mohammad
- Faraj Anwar
- Farashi Sajjad
- Fareed Mohammad
- Farioli Andrea
- Faro Andre
- Farzadfar Farshad
- Farzam Hossein
- Fatima Syeda Sadia
- Fattahi Nazir
- Fauk Nelsensius Klau
- Fazaeli Ali Akbar
- Fentahun Netsanet
- Ferede Tomas Y.
- Fereshtehnejad Seyed-Mohammad
- Fernandes Eduarda
- Fernandes João C.
- Feyissa Garumma Tolu
- Filip Irina
- Fischer Florian
- Flohr Carsten
- Foigt Nataliya A.
- Folayan Morenike Oluwatoyin
- Fomenkov Artem Alekseevich
- Forooshani Zahra Sadat Dibaji
- Foroutan Masoud
- Francis Joel Msafiri
- Fukumoto Takeshi
- Förster Jana
- Gayesa Reta Tsegaye
- Geberemariyam Biniyam Sahiledengle
- Gebrehiwot Tsegaye Tewelde
- Gebremariam Hadush
- Gebremariam Kidane Tadesse
- Gebremedhin Ketema Bizuwork Bizuwork
- Gebremeskel Gebreamlak Gebremedhn
- Gebreslassie Assefa Ayalew Ayalew
- Gebretsadik Gebretsadkan G. G.
- Gedefaw Getnet Azeze
- Geramo Yilma Chisha Dea
- Gesesew Hailay Abrha
- Geta Birhanu
- Getenet Agegnehu Bante
- Gezae Kebede Embaye
- Ghaffarifar Fatemeh
- Ghafourifard Mansour
- Ghajar Alireza
- Ghajarzadeh Mahsa
- Ghashghaee Ahmad
- Ghiasvand Hesam
- Gholamian Asadollah
- Gilani Syed Amir
- Gill Tiffany K.
- Ginawi Ibrahim Abdelmageed
- Goli Srinivas
- Gomes Nelson G. M.
- Gopalani Sameer Vali
- Goudarzi Houman
- Goulart Alessandra C.
- Govindakarnavar Arunkumar
- Grada Ayman
- Grivna Michal
- Guimarães Rafael Alves
- Guled Rashid Abdi
- Guo Yuming
- Gupta Rahul
- Gupta Rajat Das
- Gupta Rajeev
- Hafezi-Nejad Nima
- Haile Michael Tamene
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- Hamadeh Randah R.
- Hamidi Yadollah
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- Hankey Graeme J.
- Haririan Hamidreza
- Hariyani Ninuk
- Hasaballah Ahmed I.
- Hasan Md. Mehedi
- Hasankhani Milad
- Hasanpoor Edris
- Hasanzadeh Amir
- Hashemian Maryam
- Hassanipour Soheil
- Hassen Hamid Yimam
- Havmoeller Rasmus
- Hawkes Corinna
- Hay Simon I.
- Hayat Khezar
- Hayelom Desta Haftu
- Heidari Behnam
- Heidari-Soureshjani Reza
- Hendrie Delia
- Henok Andualem
- Henry Nathaniel J.
- Herrero Mario
- Herteliu Claudiu
- Heydarpour Fatemeh
- Hoang Chi Linh
- Hoek Hans W.
- Hole Michael K.
- Holla Ramesh
- Hollerich Gillian
- Hong Sung Hwi
- Hoogar Praveen
- Horino Masako
- Hossain Naznin
- Hosseini Mostafa
- Hosseinzadeh Mehdi
- Hostiuc Mihaela
- Hostiuc Sorin
- Househ Mowafa
- Hsairi Mohamed
- Hu Guoqing
- Huda Tanvir M.
- Humayun Ayesha
- Hwang Bing-Fang
- Ibitoye Segun Emmanuel
- Ilesanmi Olayinka Stephen
- Ilic Milena D.
- Imani-Nasab Mohammad Hasan
- Inbaraj Leeberk Raja
- Iqbal Usman
- Irvani Seyed Sina Naghibi
- Islam Sheikh Mohammed Shariful
- Iwu Chidozie C. D.
- Iwu Chinwe Juliana
- Izadi Neda
- Jaafari Jalil
- Jabbari Seyed Hossein Yahyazadeh
- Jaca Anelisa
- Jadidi-Niaragh Farhad
- Jafarinia Morteza
- Jahani Mohammad Ali
- Jakovljevic Mihajlo
- Jalali Amir
- Jalilian Farzad
- Jayatilleke Achala Upendra
- Jeemon Panniyammakal
- Jehan Fyezah
- Jenabi Ensiyeh
- Jha Ravi Prakash
- Jha Vivekanand
- Ji John S.
- Jia Peng
- John Oommen
- John-Akinola Yetunde O.
- Johnson Kimberly B.
- Jonas Jost B.
- Jose Bruno Piassi Sao
- Joseph Nitin
- Joukar Farahnaz
- Jozwiak Jacek Jerzy
- Jungari Suresh Banayya
- Jürisson Mikk
- Kabir Ali
- Kabir Zubair
- Kafil Hossein Samadi
- Kahsay Amaha
- Kahssay Molla
- Kalani Hamed
- Kalankesh Leila L.
- Kalhor Rohollah
- Kalhori Reza Pourmirza
- Kamiab Zahra
- Kanchan Tanuj
- Kapil Umesh
- Kapoor Neeti
- Karami Manoochehr
- Karch André
- Karim Mohd A.
- Karki Surendra
- Karyani Ali Kazemi
- Kasaeian Amir
- Kasahun Gebremicheal Gebreslassie
- Kasaye Habtamu Kebebe
- Kassa Tesfaye Dessale
- Kassaye Hagazi Gebremedhin
- Kassebaum Nicholas J.
- Kengne Andre Pascal
- Ketema Daniel Bekele
- Khader Yousef Saleh
- Khafaie Morteza Abdullatif
- Khaksarian Mojtaba
- Khalid Nauman
- Khalil Ibrahim A.
- Khalilov Rovshan
- Khan Asad
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- Khatib Mahalqua Nazli
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- Khazaei Mohammad
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- Khazaei-Pool Maryam
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- Khosravi Mohammad Hossein
- Khundkar Roba
- Kiadaliri Ali
- Kianipour Neda
- Kiirithio Daniel N.
- Kim Yun Jin
- Kimokoti Ruth W.
- Kinyoki Damaris K.
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- Mahotra Narayan Bahadur
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- Maleki Shokofeh
- Malta Deborah Carvalho
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- Manafi Farzad
- Manafi Navid
- Manohar Narendar Dawanu
- Mansour-Ghanaei Fariborz
- Mansouri Borhan
- Mansournia Mohammad Ali
- Mapoma Chabila Christopher
- Marami Dadi
- Marczak Laurie B.
- Martins-Melo Francisco Rogerlândio
- Masaka Anthony
- Massenburg Benjamin Ballard
- Matin Behzad Karami
- Maulik Pallab K.
- Mayala Benjamin K.
- Mazidi Mohsen
- Mehndiratta Man Mohan
- Mehri Freshteh
- Mehta Kala M.
- Meitei Wahengbam Bigyananda
- Mekonnen Fantahun Ayenew
- Mekonnen Teferi
- Meles Gebrekiros Gebremichael
- Meles Hagazi Gebre
- Melese Addisu
- Mendoza Walter
- Menezes Ritesh G.
- Mengesha Meresa Berwo
- Mensah George A.
- Meretoja Tuomo J.
- Mezerji Naser Mohammad Gholi
- Miazgowski Tomasz
- Miller Ted R.
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- Miri Mohammad
- Mirjalali Hamed
- Mirrakhimov Erkin M.
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- Mirzaei Maryam
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- Mohamadi Efat
- Mohamadi-Bolbanabad Amjad
- Mohammad Dara K.
- Mohammad Karzan Abdulmuhsin
- Mohammad Yousef
- Mohammadian-Hafshejani Abdollah
- Mohammadnia-Afrouzi Mousa
- Mohammadoo-Khorasani Milad
- Mohammadpourhodki Reza
- Mohammed Ammas Siraj
- Mohammed Jemal Abdu
- Mohammed Salahuddin
- Mohammed Shafiu
- Mohebi Farnam
- Mokari Amin
- Mokdad Ali H.
- Montañez Julio Cesar
- Montero-Zamora Pablo A.
- Moodley Yoshan
- Moossavi Maryam
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- Moradi Masoud
- Moradi Yousef
- Moradi-Joo Mohammad
- Moradi-Lakeh Maziar
- Moradpour Farhad
- Moradzadeh Rahmatollah
- Moraga Paula
- Morrison Shane Douglas
- Mosapour Abbas
- Mosser Jonathan F.
- Mouodi Simin
- Mozaffarian Dariush
- Mueller Ulrich Otto
- Munro Sandra B.
- Murray Christopher J. L.
- Murthy G. V. S.
- Musa Kamarul Imran
- Mustafa Ghulam
- Muthupandian Saravanan
- Nabavizadeh Behnam
- Naderi Mehdi
- Nadkarni Girish N.
- Nagaraja Sharath Burugina
- Nagarajan Ahamarshan Jayaraman
- Naghavi Mohsen
- Naheed Aliya
- Naik Gurudatta
- Najafi Farid
- Nansseu Jobert Richie
- Narayan K. M. Venkat
- Nasab Mostafa Dianati
- Nascimento Bruno Ramos
- Nayak Vinod
- Nazari Javad
- Ndwandwe Duduzile Edith
- Negoi Ionut
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- Ngunjiri Josephine W.
- Nguyen Cuong Tat
- Nguyen Huong Lan Thi
- Nigatu Dabere
- Nigatu Yeshambel T.
- Nikbakhsh Rajan
- Ningrum Dina Nur Anggraini
- Nnaji Chukwudi A.
- Nong Vuong Minh
- Noubiap Jean Jacques
- Nowak Christoph
- Oancea Bogdan
- Ofori-Asenso Richard
- Oghenetega Onome Bright
- Oh In-Hwan
- Oladimeji Olanrewaju
- Oladnabi Morteza
- Olagunju Andrew T.
- Olagunju Tinuke O.
- Olusanya Bolajoko Olubukunola
- Olusanya Jacob Olusegun
- Oluwasanu Mojisola Morenike
- Omer Muktar Omer
- Onwujekwe Obinna E.
- Oren Eyal
- Orisakwe Orish Ebere
- Ortiz Alberto
- Osarenotor Osayomwanbo
- Osgood-Zimmerman Aaron E.
- Owolabi Mayowa Ojo
- P. A. Mahesh
- Padubidri Jagadish Rao
- Pakshir Keyvan
- Pana Adrian
- Panda-Jonas Songhomitra
- Parsian Hadi
- Pashaei Tahereh
- Pasupula Deepak Kumar
- Patel Sangram Kishor
- Pathak Ashish
- Pathak Mona
- Pati Sanghamitra
- Patle Ajay
- Patton George C.
- Paulos Kebreab
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- Perico Norberto
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- Poustchi Hossein
- Prada Sergio I.
- Preotescu Liliana
- Pribadi Dimas Ria Angga
- Quintanilla Beatriz Paulina Ayala
- Rabanal Jacqueline Elizabeth Alcalde
- Rabiee Mohammad
- Rabiee Navid
- Rad Enayatollah Homaie
- Radfar Amir
- Rafiei Alireza
- Rahim Fakher
- Rahimi-Movaghar Vafa
- Rahman Muhammad Aziz
- Rahman Sajjad ur
- Rai Rajesh Kumar
- Rajabpour-Sanati Ali
- Rajati Fatemeh
- Ramezanzadeh Kiana
- Rana Saleem Muhammad
- Ranabhat Chhabi Lal
- Rao Sowmya J.
- Rarani Mostafa Amini
- Rasella Davide
- Rashedi Vahid
- Rastogi Prateek
- Rathi Priya
- Rawaf David Laith
- Rawaf Salman
- Rawal Lal
- Ray Sarah E.
- Remuzzi Giuseppe
- Renjith Vishnu
- Renzaho Andre M. N.
- Resnikoff Serge
- Rezaei Nima
- Rezaeian Shahab
- Rezai Mohammad Sadegh
- Rezapour Aziz
- Riahi Seyed Mohammad
- Ribeiro Ana Isabel
- Rickard Jennifer
- Rodriguez Alina
- Roever Leonardo
- Roro Elias Merdassa
- Roshandel Gholamreza
- Ross Jennifer M.
- Rostami Ali
- Rubagotti Enrico
- Saad Anas M.
- Saadatagah Seyedmohammad
- Sabde Yogesh Damodar
- Sabour Siamak
- Sadeghi Ehsan
- Sadeghi Masoumeh
- Safari Saeed
- Safari Yahya
- Safarpour Hamid
- Sagar Rajesh
- Sahebkar Amirhossein
- Sahraian Mohammad Ali
- Sajadi S. Mohammad
- Salahshoor Mohammad Reza
- Salam Nasir
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- Salem Marwa R. Rashad
- Salimi Yahya
- Salimzadeh Hamideh
- Sambala Evanson Zondani
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- Sarker Abdur Razzaque
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- Sarveazad Arash
- Sathian Brijesh
- Satpathy Maheswar
- Saxena Sonia
- Sayeed Muhammad Shahdaat Bin
- Sayyah Mehdi
- Sbarra Alyssa N.
- Schaeffer Lauren E.
- Schipp Megan F.
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- Schutte Aletta Elisabeth
- Schwebel David C.
- Senbeta Anbissa Muleta
- Senthilkumaran Subramanian
- Seyedmousavi Seyedmojtaba
- Shaahmadi Faramarz
- Shafaat Omid
- Shahabi Saeed
- Shaikh Masood Ali
- Shalash Ali S.
- Shams-Beyranvand Mehran
- Shamshirian Amir
- Shamsizadeh Morteza
- Shannawaz Mohammed
- Sharafi Kiomars
- Sharif Mehdi
- Sharma Rajesh
- Shehata Hatem Samir
- Sheikhtaheri Abbas
- Shibuya Kenji
- Shiferaw Wondimeneh Shibabaw
- Shigematsu Mika
- Shin Jae Il
- Shiri Rahman
- Shirkoohi Reza
- Shiue Ivy
- Shuval Kerem
- Siabani Soraya
- Siddiqi Tariq J.
- Sigfusdottir Inga Dora
- Silva Diego Augusto Santos
- Simonetti Biagio
- Singh Ambrish
- Singh Jasvinder A.
- Singh Pankaj Kumar
- Singh Pushpendra
- Singh Virendra
- Sinha Dhirendra Narain
- Sintayehu Yitagesu
- Sisay Malede Mequanent M.
- Soheili Amin
- Soleymani Bija
- Soltani Farzaneh
- Soltani Shahin
- Soriano Joan B.
- Sorrie Muluken Bekele
- Soshnikov Sergey
- Soyiri Ireneous N.
- Spotin Adel
- Sreeramareddy Chandrashekhar T.
- Srivastava Rajni Kant Kant
- Starodubova Antonina
- Sudaryanto Agus
- Sufiyan Mu’awiyyah Babale
- Suleria Hafiz Ansar Rasul
- Sulo Gerhard
- Sunguya Bruno F.
- Syed Zahiruddin Quazi
- Sykes Bryan L.
- Tabarés-Seisdedos Rafael
- Tabuchi Takahiro
- Tadesse Birkneh Tilahun
- Taherkhani Amir
- Tamirat Koku Sisay
- Tassew Segen Gebremeskel
- Taveira Nuno
- Teklehaimanot Berhane Fseha
- Tekulu Gebretsadkan Hintsa
- Temsah Mohamad-Hani
- Terkawi Abdullah Sulieman
- Tessema Zemenu Tadesse
- Thomas Nihal
- Titova Mariya Vladimirovna
- Tlaye Kenean Getaneh
- Tohidinik Hamid Reza
- Tonelli Marcello
- Toroudi Hamidreza Pazoki
- Tovani-Palone Marcos Roberto
- Traini Eugenio
- Tran Khanh Bao
- Tripathi Manjari
- Uddin Riaz
- Ullah Irfan
- Unnikrishnan Bhaskaran
- Upadhyay Era
- Useh Ushotanefe
- Usman Muhammad Shariq
- Uthman Olalekan A.
- Vacante Marco
- Vaezghasemi Masoud
- Valdez Pascual R.
- VanderHeide John
- Varavikova Elena
- Varughese Santosh
- Vasankari Tommi Juhani
- Vasseghian Yasser
- Vecchia Carlo La
- Veisani Yousef
- Venkatesh Srinivasaraghavan
- Venketasubramanian Narayanaswamy
- Verma Madhur
- Vidale Simone
- Violante Francesco S.
- Vlassov Vasily
- Vollmer Sebastian
- Vukovic Rade
- Waheed Yasir
- Wang Haidong
- Wang Yafeng
- Wang Yuan-Pang
- Weldesamuel Girmay Teklay
- Werdecker Andrea
- Wiangkham Taweewat
- Wiens Kirsten E.
- Wijeratne Tissa
- Wolde Haileab Fekadu
- Wondafrash Dawit Zewdu
- Wonde Tewodros Eshete
- Wondmieneh Adam Belay
- Wu Ai-Min
- Xu Gelin
- Yadegar Abbas
- Yadollahpour Ali
- Yamada Tomohide
- Yano Yuichiro
- Yaya Sanni
- Yazdi-Feyzabadi Vahid
- Yeshaneh Alex
- Yeshaw Yigizie
- Yeshitila Yordanos Gizachew
- Yilma Mekdes Tigistu
- Yip Paul
- Yonemoto Naohiro
- Yoon Seok-Jun
- Youm Yoosik
- Younis Mustafa Z.
- Yousefi Zabihollah
- Yousof Hebat-Allah Salah A.
- Yu Chuanhua
- Yusefzadeh Hasan
- Zahabi Saleh Salehi
- Zaki Leila
- Zaman Sojib Bin
- Zamani Mohammad
- Zamanian Maryam
- Zandian Hamed
- Zarafshan Hadi
- Zepro Nejimu Biza
- Zerfu Taddese Alemu
- Zewale Taye Abuhay
- Zhang Yunquan
- Zhang Zhi-Jiang
- Zhao Xiu-Ju
- Zodpey Sanjay
- Zomorodian Kamiar
- Zotor Francis Bruno
- Ärnlöv Johan
- Publication venue
- Nature Research
- Publication date
- 01/01/2020
- Field of study
A double burden of malnutrition occurs when individuals, household members or communities experience both undernutrition and overweight. Here, we show geospatial estimates of overweight and wasting prevalence among children under 5 years of age in 105 low- and middle-income countries (LMICs) from 2000 to 2017 and aggregate these to policy-relevant administrative units. Wasting decreased overall across LMICs between 2000 and 2017, from 8.4% (62.3 (55.1–70.8) million) to 6.4% (58.3 (47.6–70.7) million), but is predicted to remain above the World Health Organization’s Global Nutrition Target of <5% in over half of LMICs by 2025. Prevalence of overweight increased from 5.2% (30 (22.8–38.5) million) in 2000 to 6.0% (55.5 (44.8–67.9) million) children aged under 5 years in 2017. Areas most affected by double burden of malnutrition were located in Indonesia, Thailand, southeastern China, Botswana, Cameroon and central Nigeria. Our estimates provide a new perspective to researchers, policy makers and public health agencies in their efforts to address this global childhood syndemic
Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study
- Author
- Liza
- - AP-HP) Bertrand Dousset (H\uf4pital Cochin
- - APHP) Anne Thomin (H\uf4pital Trousseau
- - ASST Rhodense) Carlo Corbellin (Ospedale Di Rho
- - NYU Winthrop Hospital) Amir H Sohail (NYU Langone Health
- - Xarxa Assistencial Universit\ue0ria de Manresa) Pablo Collera Ormazabal (Fundaci\uf3 Althaia
- / Columbia University Medical Center) Miriam Callahan (NewYork-Presbyterian
- 3 University Hospital) Bridget Egan (Tallaght
- 4 Lapolla Pierfrancesco
- 5 Spain: Eduardo E Rubio Susana Henriques (Hospital Garcia de Orta).
- 6 G\uf3mez Marcos
- \u2013 IRCCS Francesca Gaino (Humanitas Clinical and Research Center
- \u2013 Italy) 20089 Rozzano (MI)
- \uc1ngel Hern\ue1ndez Bartolom\ue9 Miguel
- A Aaraj Mahmoud
- A Ayeni Funbi
- A Bass Gary
- A Benson Ruth
- A Bozkurt Mehmet
- A Breen Kerry
- A Breen Kerry
- A Breen Kerry
- A Callcut Rachael
- A Chung Eric
- A Coughlin Patrick
- A de Gheldere Charles
- A De Marchi Joshua
- A Elliott Jessie
- A Fahey Brian
- A Griffiths Ewen
- A Griffiths Ewen
- A Griffiths Ewen
- A Guariglia Claudio
- A Hirji Sameer
- A Khalefa Mohamed
- A Marra (Fondazione Policlinico Universitario Agostino Gemelli) Angelo
- A Nguyen (Frankfurt University Hospital Truong
- A Olson (Duke University Medical Center) Steven
- A Raptis Dimitri
- A Rollett Rebecca
- A Saeed Samerah
- A Salama Hiba
- A Salamah Abdulrauf
- A Schnitzbauer Andreas
- A Schnitzbauer Andreas
- A Singh Aminder
- A Stevens Kent
- A Stylianides Nicholas
- A Thaha Mohamed
- A Vega (12 de Octubre University Hospital) Viviana
- A Vivas Alfredo
- A Zappa Marco
- Abate Emmanuele
- Abdalaziz (Gloucestershire Royal Hospital) Hossam
- Abdelkarim Mostafa
- Abdou Hossam
- Aboelkassem-Ibrahim Ahmad
- Abuown Ala
- Acebes-Garcia Fernando
- Acharya Metesh
- Adamina Michel
- Addae-Boateng Emmanuel
- Adolfo Pisanu (Cagliari University Hospital) Mauro Podda
- Aftab Raiyyan
- AG Moir John
- Agarwal Arnav
- AH Ibrahim Mohamed
- Aitken (Queen Elizabeth University Hospital) Emma
- Al-Azzawi Marwa
- Al-Embideen Somya
- Al-Sukaini Ahmad
- Alakaloko Felix
- Alam (Heartlands Hospital) Ruhina
- Alameer Ehab
- Alderson Derek
- Ali Mohamed Ali (Queen Elizabeth Hospital King's Lynn) Inthekab
- Aliyeva (Acibadem Mehmet Ali Aydinlar University Zumrud
- Aljanadi Firas
- Almasri Murad
- Alonso Poza (Hospital Universitario del Sureste) Alfredo
- Alonso-Ortu\uf1o Paula
- Alser Osaid
- Alser Osaid
- Alser Osaid
- Altintoprak (Sakarya University Faculty of Medicine) Fatih
- Amalina Che Bakri Nur
- Amjad Rabbia
- Anania Gabriele
- and Westminster Hospital NHS FT and Imperial College London) Chelsea
- Andabaka Tatjana
- Andrea Pisani Ceretti (ASST Santi Paolo e Carlo) Nicol\uf2 M Mariani
- Angelou Dimitrios
- Anita Volpe (New York Presbyterian Queens) Stephen Merola
- Annamalai Seethalakshmi
- Annessi Valerio
- Anthoney James
- Anuradha R Bhama (Rush University Medical Center) Alfonso Torquati
- Anwar Sibtain
- Aragon-Chamizo Juan
- Ardito Antonella
- Arigoni Michele
- Armao Teodora
- Arminio (Ospedali Riuniti Azienda Ospedaliera Universitaria Foggia) Armando
- Armstrong Lara
- Asaad Peter
- Ashcroft James
- Ashmore Christopher
- Asqalan Ahmad
- Asti (IRCCS Policlinico San Donato Emanuele
- Aubry Emmanuelle
- Aytac Erman
- Ayuso-Herrera Esther
- Azerbaijan:Elgun Samadov Joana FF Simoes (Chair). 2 Collaborators: (denotes Local Principal Investigator) Algeria: Faraj S Almaadany (\uc9tablissement Hospitalier Sp\ue9cialis\ue9 en Canc\ue9rologie - Centre Pierre-et- Marie-Curie).
- B Avellana Rocio
- B Catton Andrew
- B Fonsi Giovanni
- B Hing Caroline
- B O'Meara Lindsay
- B Schaffer Kathryn
- B Yousuf (Tobruk Medical Center) Farhat
- B\ue0mbina (Fabrizio Spaziani Hospital Fabrizio
- Bailon-Cuadrado (Hospital Universitario R\uedo Hortega) Martin
- Baldi Caterina
- Baldini Edoardo
- Baldo (Ospedale Santa Corona Stefano
- Ballabio Michele
- Baloyiannis Ioannis
- Baltazar Gerard
- Bandiera Alessandro
- Barlow Emma
- Barmasse (Ospedale Regionale Umberto Parini) Roberto
- Barmpagianni Christina
- Baronio (Policlinico San Pietro) Gianluca
- Barra Fabio
- Bartholomew's Hospital) St
- Bartsch Anne-Marie
- Basgaran Amedra
- Basha Amr
- Bashkirova (North Middlesex University Hospital) Varvara
- Bastazza Marco
- BB Sullivan (The Royal London Hospital) Tom
- Beak Philip
- Belcher Elizabeth
- Belgium: Gabrielle H van Ramshorst Sevda Jafarova (Leyla Medical Center).
- Beltr\ue1n de Heredia Juan
- Belvedere Angela
- Ben\uedtez-Linero Inmaculada
- Benjamin Franklin) Campus
- Bergeat Damien
- Bernasconi Matteo
- Bhalla Ashish
- Bhangu Aneel
- Bianco Federica
- Bisagni Pietro
- BJ Borgstein Alexander
- Blake (Southport and Formby District General Hospital) Iain
- Blanco-Colino Ruth
- Blazquez-Martin (Hospital Principe De Asturias) Alma
- Boal Matthew
- Bologna) Ausl
- Bonavina Giulia
- Bonavina Luigi
- Bond-Smith Giles
- Booth (Freeman Hospital) Karen
- Borges Filipe
- Borghi Felice
- Borja De Lacy (Hospital Clinic Barcelona) F
- Bourke Grainne
- Boyle Emily
- Brachini Gioia
- Brain Jessie
- Brar Amanpreet
- Breckles Lisa
- Brendan L Skelly (Altnagelvin Area Hospital) Catherine Rossborough
- Brianza) Carate
- Brixton Genevieve
- Bruzzaniti Placido
- Bueser Teofila
- Burnside Nathan
- C Bosanquet David
- C Brown (Manchester University NHS Foundation Trust Benjamin
- C De Souza Anthony
- C Glasbey James
- C Glasbey James
- C Hopkins James
- C Lauscher Johannes
- C McIntyre Robert
- C Mckay Siobhan
- C Neary Paul
- C Nugent III William
- C Rodriguez-Sanjuan (Marqu\ue9s de Valdecilla University Hospital) Juan
- C Roslani April
- C Tucker Sarah
- C Velmahos (Massachusetts General Hospital) George
- C Winter Stuart
- Caballero Albert
- Cairo University) Mahmoud MA Elfiky (Kasr Alainy Faculty of Medicine
- Calcerrada-Alises Enrique
- Camacho Fern\ue1ndez-Pacheco (Complejo Hospitalario Universitario Insular-Materno Infantil) Borja
- Camarero Enrique
- Campagnaro Tommaso
- Campanelli Michela
- Candiani Massimo
- Cannoletta (Royal Brompton Hospital) Marina
- Cantalejo-Diaz (Hospital Universitario Miguel Servet) Miguel
- Cao Han
- Capizzi Vita
- Carcano (Ospedale di Circolo Giulio
- Carissimi Francesca
- Carlini Massimo
- Carlos Bernal-Sprekelsen Juan
- Carlos Catal\ue1 Bauset (Consorcio Hospital General Universitario) Juan
- Carlucci Michele
- Carmela Giuffrida Maria
- Carmichael Heather
- Carrasco Milagros
- Carrillo Mariana
- Carvello Michele
- Casati Massimiliano
- Castoro Carlo
- Castro Ruiz Carolina
- Catalan Vanesa
- Catriona R Luney (Nuffield Orthopaedic Centre) Benjamin JF Dean
- Cavaleiro Salom\ue9
- Cellerino Paola
- Center Amsterdam) Cancer
- Centinaio (Ospedale Maggiore di Lodi) Giovanna
- Cernei Cristina
- Cervellera Maurizio
- Chakrabortee Sohini
- Chamberlain Stephanie
- Chan Jeffrey
- Chang Grace
- Chaudhry Daoud
- Chebaro Alexandre
- Chen (Jamaica Hospital) David
- Chetty Govind
- Chia (Royal Derby Hospital) Zoe
- Chiappini Ambra
- Chiarugi (Azienda Ospedaliero Universitaria Pisana) Massimo
- Chidambaram Swathikan
- Chiozza Matteo
- Cholewa Hanna
- Chong (Evelina London Children's Hospital) Clara
- Choolani-Bhojwani Ekta
- Christian Cotsoglou (ASST Vimercate) Stefano Granieri
- Chui Karen
- Chung Choyin
- Cirillo Bruno
- Citterio Davide
- Clermidi Pauline
- Coccolini Federico
- Colletti Gaia
- Compagnoni Bruno
- Concepci\uf3n-Mart\uedn Vanesa
- Confalonieri Marco
- Connolly Hannah
- Conso Christel
- Conti Luigi
- Cooper Zara
- Corral Javier
- Costa Marta
- Costanzi Andrea
- Cox Daniel
- Cozza Valerio
- CR Wormald Justin
- Croatia: Jakov Mihanovic Nicolas Duchateau (Heilig Hart Ziekenhuis Lier).
- CS Clough Ethan
- Cuming Tamzin
- Cuneo)
- Curtis Miles
- Cuschieri Joseph
- D Baron Ryan
- D Bosch Karen
- D Brown Oliver
- D Bueno-Ca\uf1ones Alejandro
- D Cato Liam
- D Drake Thomas
- D Jenkinson Michael
- D Jenkinson Michael
- D Liyanage Aloka S
- D Pinkney Thomas
- D Rajgor Amarkumar
- D Stewart Grant
- D Tebala Giovanni
- D'Agruma Michele
- D'Andrea Giancarlo
- D\uedaz P\ue9rez David
- D\uedaz-Garc\ueda (Hospital Universitario Nuestra Se\uf1ora de Candelaria) Alberto
- Da Roit Anna
- da Saliceto\u201d Patrizio Capelli (Ospedale \u201cG.
- Dare Oliver
- Darko Ebenezer
- Data Monitoring and Ethics Committee: Deborah S Keller H. Hunt Batjer (University of Texas Southwestern).
- Day Andrew
- De Andr\ue9s-Asenjo Beatriz
- de Medicina Facultad
- De Miguel-Ardevines Maria-Carmen
- De Nardi Paola
- De Simone Veronica
- De Toma Giorgio
- Deepti Sinha (University College London Hospital) Nicholas Kalavrezos
- Dehal (Kaiser Permanente Panorama City Medical Center) Ahmed
- Dehart Dustin
- Del Giudice Roberto
- Delgado-Oliver Eduardo
- Denmark: Henry G Smith Bernarda Bakmaz (Zadar General Hospital).
- Denning Max
- Desai Anant
- Desender (Ghent University Hospital) Liesbeth
- Dester (ASST Valcamonica Ospedale di Esine) Sara
- Di Candido Francesca
- Di Chiara Francesco
- Di Franco Gregorio
- Di Giuseppe (Ente Ospedaliero Cantonale del Canton Ticino) Matteo
- Di Saverio Salomone
- Di Saverio Salomone
- Di Saverio Salomone
- Di Saverio Salomone
- Diaz-Pe\uf1a Patricia
- Dieguez Fernandez Beatriz
- Dissemination Committee: Michel Adamina Aneel Bhangu.
- Dolores Del Toro M
- Domodossola
- Doussot Alexandre
- Duff Sarah
- Dunning Joel
- Dunstan Matt
- Duque-Mallen Victoria
- Dziakova Jana
- E Canova Michaela
- e Carle Hospital Chiara Peluso (Santa Croce
- e Carlo ASST Santi Paolo
- E Dawson Brett
- E Dickson Kathryn
- E Hudson Victoria
- E Jenny (Johns Hopkins Hospital) Hillary
- E Lewis Sophia
- E Nita George
- e Oftalmico) Giulio Iacob (Ospedale Fatebenefratelli
- E P\ue9rez-S\ue1nchez Luis
- E Rice Henry
- E Ssentongo Anna
- e Universit\ue1rio de Coimbra) Ana C Almeida (Centro Hospitalar
- E Xyda Souzana
- Edward Fitzgerald J
- EF Abbott Tom
- EF Abbott Tom
- Egan Richard
- Egypt: Mohamed El Kassas University of Copenhagen).
- El Youzouri Hanan
- El-Ali (Queen's Hospital Abess
- Elaine YL Leung (The Pan Birmingham Gynaecological Cancer Centre) Sudha Sundar
- Elfeki Hossam
- Elhadi Muhammed
- Eljareh (Aljalaa Hospital) Mohammed
- Elkadi Hannah
- Elkady Ramy
- Elkhafeefi Fatimah
- Elmore Ugo
- Elmoslemany (The Walton Centre NHS Foundation Trust) Tarek
- EM Bouhuwaish Ahmad
- EM Brathwaite Collin
- Emmerson (North Manchester General Hospital) Oliver
- Enemosah Ibrahim
- English Camilla
- English William
- Ereidge Simon
- Escartin Jorge
- Estaire-Gomez Mercedes
- EuroSurg
- Evans (Queen Elizabeth the Queen Mother Hospital Margate) Jessica
- Exley Rebecca
- F Bath Michael
- F Cunha Miguel
- F Cunha Miguel
- F Davis Niall
- F Ridgway Paul
- Fabbri Nicol\uf3
- Falco Giuseppe
- Familiari Pietro
- Fancellu (Cliniche San Pietro Alessandro
- Fanjul G\uf3mez Mar\ueda
- Farik Shebani
- Farr\ue9 Font Roser
- Farrell Tony
- Fehervari Matyas
- Fell Adam
- Fern\ue1ndez- Mart\uednez Mar\ueda
- Fern\ue1ndez-Gomez Cruzado (Hospital Urduliz) Laura
- Fern\ue1ndez-Mar\uedn Reyes
- Fernandez-Camu\uf1as Angel
- Ferrara)
- Ferrara Francesco
- Ferrari Guglielmo
- Ferrero Simone
- FF Simoes Joana
- FF Simoes Joana
- Findlay Laura
- Fiore Marco
- Fiore Marco
- Fiori Enrico
- FJ Dunne Declan
- Flatman Michael
- Flindall Ian
- Fontana (Vittorio Emanuele Tommaso
- Ford (The Robert Jones and Agnes Hunt Orthopaedic Hospital) David
- Ford Samuel
- Forlani Stefano
- Fr\ue9d\ue9ric Bretagnol (H\uf4pital Louis-Mourier - GHU AP-HP. Nord - Universit\ue9 de Paris) David Moszkowicz
- France: Zaher Lakkis Mohamed Sherief (MISR Cancer Center/MISR International Hospital).
- Francisco de Vitoria Universidad
- Francone Elisa
- Frattaruolo Colomba
- Frio (Institute of Neurological Sciences of Bologna Federico
- Frosinone)
- G Aoun Salah
- G Barranquero Alberto
- G Blazer III Dan
- G Collins Chris
- G Edwards John
- G Edwards John
- G Morton Dion
- G Povey Meical
- G Velopulos Catherine
- G Wade Ryckie
- Gabriel Kinnaman (IU Health Methodist Hospital) Ashley D Meagher
- Gagliano Annalisa
- Gagliardi Filippo
- Gahunia Sukhpreet
- Gala Tanzeela
- Galfrascoli Elisa
- Galimberti Luca
- Galindo Jara (Hospital Universitario de Torrej\uf3n Pablo
- Gallagher Phoebe
- Galleano Raffaele
- Gallo Gaetano
- Gallo Gaetano
- Gallo Gaetano
- Galv\ue1n-P\ue9rez Armando
- Gamal Amira Ibrahim Sallam
- Gammeri Emanuele
- Ganau Mario
- Garc\ue9s-Garc\ueda Ra\ufal
- Garcia Fernandez Andres
- Garcia-Conde Delgado Maria
- Garulli (Ospedale Infermi di Rimini) Gianluca
- Gascon-Ferrer Isabel
- Gattolin (Regina Montis Regalis Hospital Andrea
- Gaujoux Sebastien
- Gentilli Sergio
- Georgiades Fanourios
- Germany: Carsten Kamphues Didier Ollat (Institut Mutualiste Montsouris).
- Gerogiannis (Kingston Hospital NHS Foundation Trust) Ioannis
- Ghanbari (Homerton University Hospital) Amir
- Ghosh Dhruv
- Giacometti Marco
- Giblin Anna-Victoria
- Gilbert (Surrey and Sussex Healthcare NHS Trust) Catherine
- Gim\ue9nez Clara
- Giorgakis Emmanouil
- Gipponi Manuel
- Glen Paul
- GlobalPaedSurg GlobalSurg
- Goatly Giles
- Gobatti (San Carlo Borromeo Hospital Davide
- Godbole Chintamani
- Gohil Kajal
- Gomez-Rosado Juan-Carlos
- Gonullu Emre
- Gonzalez-De Miguel Melania
- Gonzalez-Gonzalez Enrique
- Gordini Luca
- Gracia Isabel
- Gracia-Roche Carlos
- Greece: Konstantinos Bouchagier Markus W L\uf6ffler (University Hospital Tu\u308bingen).
- Green Susanna
- Grivon Manuela
- Grove (Department of Colorectal Surgery Thomas
- Guaglio Marcello
- Guaitoli (Perrino) Eleonora
- Guglielmi Alfredo
- Guha Soumya
- Gustavino (Unit of Obstetrics and Gynecology IRCCS Ospedale Policlinico San Martino Genoa) Claudio
- Guti\ue9rrez Samaniego Mar\ueda
- H Babu Bheemanakone
- H Chowdhury Abeed
- H Davidson Giana
- H Davidson Giana
- H Davidson Giana
- H Elfallal Ahmed
- H Emile Sameh
- H Kirmani Bilal
- H Liu Helen
- H Murphy Suzanne
- H van Ramshorst Gabrielle
- H\uf6lzle Frank
- Habeeb Amir
- Hagger Robert
- Hakmi Hazim
- Halkias Constantine
- Halkias Constantine
- Hampton (Rotherham District General Hospital) Matthew
- Handa Siddhartha
- Haq Iram
- Harky (Liverpool Heart and Chest Hospital) Amer
- Harries (Morriston Hospital Rhiannon
- Harrison Joseph
- Hasan Raashad
- Hawari Mohammad
- Hawkin Paul
- Hebblethwaite Bethany
- Helier University Hospitals NHS Trust) St
- Heritage Emily
- Hernandez Garcia Miguel
- Hernandez-Juara Pilar
- Herrero-Lopez Maria
- Hervieux Erik
- Heyd Bruno
- Higgs Simon
- Hitchman (Hull University Teaching Hospitals NHS Trust) Louise
- Ho Beatrice
- Hogan Aisling
- Hospital of Varese University
- Hospital Universitario del Henares) Miguel Angel Garcia-Ure\uf1a (Universidad Francisco de Vitoria
- Hospital) Atakent
- Hospital) Wythenshawe
- Hossain Tanvir
- Houston Roy
- Hurt Libor
- HV Byrne Matthew
- i Pujol) Alba Zarate (Hospital Germans Trias
- I Roxo (Brigham and Women's Hospital) Vanessa
- I van Berge Henegouwen (Amsterdam UMC Mark
- I Alessandro Di Bartolomeo (Policlinico Umberto
- Iannone Immacolata
- Ibrahim Sherif
- Iovino Domenico
- Ireland: Arnold DK Hill Paraskevi Tourountzi (Kavala General Hospital).
- Isik Arda
- Israel: Oded Zmora Thomas M Aherne (Galway University Hospital).
- Italy: Maurizio Zizzo Nadav Kugler (Shamir Medical Center).
- J Abbott Sarah
- J Baker Olivia
- J Baldwin Alexander
- J Beamish Andrew
- J Carlos William
- J Caruana Edward
- J Caruana Edward
- J Davies Emma
- J Diaz Jose
- J Doe Matthew
- J Eardley Nicola
- J Fern\ue1ndez Antonio
- J G\uf3mez D\uedaz Carlos
- J Hainsworth Alison
- J Hall Bria
- J Holme Thomas
- J Hutchinson Peter
- J Hutchinson Peter
- J Kalkwarf Kyle
- J Lin Daniel
- J Lowery Aoife
- J McCluney Simon
- J Mehigan Brian
- J Mills Sarah
- J Pachl (Birmingham Children's Hospital) Max
- J Rogers Luke
- J Ryan \uc9anna
- J Scurrah Rachel
- J Shackcloth Michael
- J Smart Neil
- J Steinkamp Pieter
- J Tejero-Pintor Francisco
- J Thomas Amy
- J Torres Antonio
- J Warren Oliver
- J Warren Oliver
- J Williams Katherine
- James RW Hall (Stepping Hill Hospital) Claire Hall
- James's Hospital) Conor P Barry (St.
- Jamil Tahir
- Jayaraju (University Hospital of Wales) Ullas
- Jenner Edward
- JG Chase Thomas
- Jha Shane Lester (James Cook University Hospital) Madan
- Jimenez-Higuera Elisa
- Jimeno Jaime
- JM Dunne Naomi
- JM Ferguson Henry
- Jo\ue3o Lima Maria
- Johnstone Jack
- Jones Mark
- Jordan: Mahmoud Al-Masri Gela).
- JS Wall Joshua
- Judkins Nicholas
- JW Wilkin Richard
- K Abou Chaar Mohamad
- K Ambler Graeme
- K Bankhead-Kendall Brittany
- K Bankhead-Kendall Brittany
- K Bankhead-Kendall Brittany
- K Brown Allison
- K Fusai Giuseppe
- K Gill Charn
- K Kamarajah Sivesh
- K Patel Panna
- K Ubhi Harmony
- K Weerasinghe Chamindri
- K\uf6nigsrainer Alfred
- Kalidindi Venugopala
- Kamal Mona
- Kang Chong
- Kara Yasin
- Karam Edward
- Karim Ahmed
- Kashora Florence
- KC Jonker (University Medical Center Groningen (University of Groningen) Pascal
- Kearney (Beaumont Hospital) David
- Khajuria Apoorva
- Khan Azam
- Khan Umul
- Khatri Chetan
- Kinross James
- Kler Aaron
- Klimopoulos (Evangelismos General Hospital) Serafeim
- Kocata\u15f (Kanuni Sultan Suleyman Training and Research Hospital) Ali
- Kolias Angelos
- Kolias Angelos
- Kontovounisios Christos
- Kourdouli (Leicester Royal Infirmary) Amar
- Krishnan Emily
- Kristinsson Sverrir
- Kruijff Schelto
- KS Viswanath Yirupaiahgari
- Kudsk-Iversen S\uf8ren
- Kufeji Dorothy
- Kulkarni Rugved
- Kurihara Hayato
- L Biffl Walter
- L Coleman Natasha
- L Collins Michelle
- L Engel (Temple University Hospital) Jamie
- L Fowler Amy
- L Garcia Galocha Jose
- L Hughes Jane
- L J\uf6nsson (Bispebjerg Hospital Maria
- L Labib Peter
- L Marsh (Scripps Memorial Hospital) Christopher
- L McKevitt Kevin
- L Osorio Alexander
- L Romera Jose
- L Serevina Olivia
- L Venn Mary
- L Venn Mary
- L Venn Mary
- L Wright Franklin
- L Young Alastair
- L\ue1zaro Andr\ue9
- La Torre Filippo
- Laface (Ospedale Vittorio Emanuele III Letizia
- Lami Mariam
- Landaluce-Olavarria Aitor
- Laura Hansen 9
- Lawani Ismail
- Lawday (Southmead Hospital) Samuel
- Lawday Samuel
- Le Roy Bertrand
- Lecco) Asst
- Lecolle Katia
- Lederhuber Hans
- Lederhuber Hans
- Leeds)
- Leicester)
- Leventoglu Sezai
- Li Elizabeth
- Li Elizabeth
- Li Zoe
- Libya: Ghadah Z Alkadeeki Hani Al-Najjar (King Hussein Cancer Center).
- Liew Ignatius
- Ligure (SV) Pietra
- Lima Buarque Igor
- Lisi Giorgio
- Lizzi Vincenzo
- Lo Terence
- Lombardia) Regione
- Lomiento Daniele
- Longhi Marco
- Lopez Antonanzas (Hospital Clinico San Carlos Leyre
- Losada Ruiz Manuel
- Lostis Emilie
- Lostoridis Eftychios
- Loubani Mahmoud
- Lowy- Benoliel Alejandro
- Lucianetti (Papa Giovanni XXIII Hospital) Alessandro
- Luigi MP Marino Cosentino (PO San Filippo Neri - ASL ROMA 1) Andrea Sagnotta
- luis Blas Laina Juan
- Luke Evans (Norfolk and Norwich University Hospital) Mina MG Youssef
- Luke Louis
- Lunevicius Raimundas
- Luraghi Marco
- Lye George
- M Alrahawy (Menofiya University Hospital) Mahmoud
- M Andreani Stefano
- M Ashoush Fouad
- M Bajomo Oreoluwa
- M Blundell Chris
- M Cicerchia Pierfranco
- M Connolly Tara
- M Diez-Alonso Manuel
- M Dur\ue1n-Mu\uf1oz-Cruzado (Hospital Universitario Virgen del Rocio) Virginia
- M Emslie Katy
- M Harrison Ewen
- M Holbrook Charlotte
- M Isolani Simone
- M Keatley James
- M Leite-Moreira Andr\ue9
- M Mithany Reda H
- M Mohan Helen
- M Mohan Helen
- M Monteiro Joana
- M Morgom (Tripoli Central Hospital) Marwa
- M Muguerza Jose
- M Nunes Quentin
- M Nygaard Rachel
- M Omar Aneel Bhangu Omar
- M Philp Matthew
- M Pollok Joerg
- M Rooney Siobhan
- M Sampietro Gianluca
- M Sewards Joseph
- M Tang Alethea
- M Trout Isobel
- M Walters (Harborview Medical Center Andrew
- MA Kaafarani Haytham
- MA Kaafarani Haytham
- MA Kaafarani Haytham
- Maarten van Heinsbergen (VieCuri Medisch Centrum) Joop Konsten
- Mabrouk Islam
- Macchi Alberto
- MacDonald Luisa
- Machairas (Royal Free Hospital) Nikolaos
- Madonini Marco
- Madrid)
- Madrid)
- Magalh\ue3es Maia Mariana
- Magne Augestad Knut
- Magowan Drew
- Maha H Haqqani (Boston Medical Center) Frederick T Drake
- Maisonneuve Emeline
- Majkowska Agata
- Majkowski (Northern General Hospital Lawrence
- Mak (Queen Elizabeth Hospital Birmingham) Jason
- Malabarba Stefano
- Malerba Michele
- Maninder Kalkat 7
- Mannan Syed
- Manson Joanna
- Mansuri Ahmer
- Mantoglu (Sakarya University Research and Educational Hospital) Baris
- Manu Nichola
- Manzoni 56 Via
- Maqsood Afnan
- Marano Alessandra
- Marchbank Adrian
- Marcos-Santos Pablo
- Marinos Kouris (Buckinghamshire Healthcare NHS Trust) Spyros
- Marqueta De Salas Maria
- Marrano Enrico
- Mart\uedn-Rom\ue1n Lorena
- Mart\uednez P\ue9rez Carolina
- Mart\uednez-dePaz Fernando
- Martel Lozano Saida
- Martin (St Mary's Hospital) Guy
- Martin Emmeline
- Martin Janet
- Martin-Albo Lorena
- Martine Uittenbogaart (M\ue1xima Medical Center) Wouter KG Leclercq
- Martinelli Fabio
- Martinez-German Antonio
- Martinez-Pinedo Carlos
- Martins Ricardo
- Marwan Hisham
- Marzi Federica
- MAS Baig Mirza
- Mateos-Sierra (Hospital General Universitario Gregorio Mara\uf1\uf3n) Olga
- Mater Studiorum University of Bologna) Alma
- Mathieu (CHU Besan\ue7on) Pierre
- Matute-Najarro Maria-Soledad
- Maw Andrew
- Mazingi Dennis
- Mazzaferro (Fondazione IRCCS Istituto Nazionale dei Tumori Vincenzo
- McCanny (Antrim Area Hospital) Andrew
- McKenzie Katherine
- McLarty (Northumbria NHS Hospital Trust) Nicola
- McPherson Iain
- Medina Esther
- Mediratta Saniya
- Medone Marzia
- Mehra (Guy's and St Thomas\u2019 NHS Foundation Trust) Gautam
- Mele Simone
- Melero-Cort\ue9s Lidia
- Melody Baeza (Morales Meseguer University Hospital) Jos\ue9 Aguilar
- Mendon\ue7a Ata\uedde Gomes Gustavo
- Mendoza-Moreno Fernando
- Meneghini Simona
- Merate
- Mercante Giuseppe
- Merdrignac (Rennes University Hospital) Aude
- Metallidis Symeon
- Michel (Pinderfields Hospital) Martin
- Migliore Marco
- Milan)
- Milan)
- Milan)
- Miller Douglas
- Minaya- Bravo Ana
- Minaya-Bravo Ana
- Minaya-Bravo Ana
- Minaya-Bravo Ana
- Mingoli Andrea
- Minto Gary
- Mirabella Antonello
- Misra Nikhil
- Mitrasinovic Stefan
- Miu Victor
- Moawad (Royal Victoria Hospital) Nader
- Mochet Sylvie
- Modabber Ali
- Mohammad Adam
- Mohan Midhun
- Moliner-S\ue1nchez Carmen
- Mondov\uec)
- Mongelli Francesco
- Monteleone (Ospedale San Leopoldo Mandic Michela
- Montuori Mauro
- Moore Rachel
- Mora-Guzm\ue1n (Hospital Santa B\ue1rbara) Ismael
- Morales Dieter
- Morales Xavier
- Morelli Luca
- Morelli Lucia
- Morgan Richard
- Morris Chris
- Mortini Pietro
- Mosca Angelo
- Moszkowicz David
- Moszkowicz David
- Motter Dema
- Moug Susan
- Mukherjee Samrat
- Munoz Rivas Ana
- Murcia)
- N Bence Matthew
- N Hopkinson David
- N Mashbari Hassan
- N Mashbari Hassan
- N Mashbari Hassan
- N Naumann David
- N Rao Jagan
- N Townshend David
- N\ufa\uf1ez Jordi
- Najdy Manhal
- Nakas (Glenfield Hospital Apostolos
- Namazov Ilgar
- Naredla Pradyumna
- Nasef Emmhamed
- Nassa Heeam
- Nath Rahul
- Navarro-S\ue1nchez Antonio
- Nazarian (Bupa Cromwell Hospital) Scarlet
- Neal Bhutiani (University of Louisville Hospital and Norton Hospital) Robert CG Martin
- Negri Giampiero
- Nehra Deepika
- Neil-Dwyer Jason
- Nepogodiev Dmitri
- Nepogodiev Dmitri
- Nepogodiev Dmitri
- Neri Jacopo
- Netherlands: Suzanne S Gisbertz Mustafa R Bulugma (Zawia Teaching Hospital). Mexico: Fernando Cordera (ABC Medical Center).
- Newton (Manchester Royal Infirmary) Katy
- Nikaj (Azienda Ospedaliero Universitaria Maggiore della Carit\ue0 Herald
- Niquen Milagros
- Nobile (Azienda Ospedaliera Universitaria Integrata di Verona) Sara
- Nogueiro Jorge
- Nogues Pevidal (Royo Villanova) Ana
- Novara)
- Ntirenganya Faustin
- Nugent Michael
- O Ademuyiwa Adesoji
- O Kavanagh Dara
- O Larkin John
- Oca\uf1a Juan
- of Amsterdam University
- of Ferrara) University
- of Insubria University
- of Milan) University
- of Surgeons in Training (ASiT) Association
- of Surgery) Department
- of Washington) University
- Okafor Barbara U.
- Okechukwu Valentine
- Oliva-Mompean (Hospital Universitario Virgen Macarena) Fernando
- Oliveira Ana
- OM Abdalla Mutwakil
- Omar M Omar
- OO Ayorinde John
- Osagie-Clouard (Epsom &
- Osman (Walsall Manor Hospital) Khabab
- Ottolina Jessica
- Ourieff (Mount Sinai Hospital) Jared
- Outani Oumaima
- Oyewole Bankole
- P Arnaud Alexis
- P Arnaud Alexis
- P Arnaud Alexis
- P Baker Markus
- P Belgaumkar Ajay
- P Boddy Alexander
- P Duffy (Nottingham City Hospital) John
- P Evans Jonathan
- P Hazelton Joshua
- P Jones Andrew
- P Jones Robert
- P Joyce Doireann
- P Kisiel Aaron
- P Pezzuto Anna
- P Singh Rabindra
- P\ue9rez-Gonz\ue1lez Marta
- P\ue9rez-Saborido Baltasar
- Pacheco-Sanchez David
- Padilla-Valverde (Hospital General Universitario De Ciudad Real) David
- Pai (Hammersmith Hospital) Madhava
- Paiella Salvatore
- Paisley (Brighton and Sussex NHS Trust Samuel
- Palermo)
- Palini Gianmarco
- Palmeri Matteo
- Parente Alessandro
- Parlanti Daniele
- Parmar Chetan
- Pascual Angela
- Pata Francesco
- Pata Francesco
- Patel Mahul
- Pathak Abhijit
- Patil Sangram
- Pattyn Piet
- Peckham- Cooper Adam
- Pedram Panahi (University Hospitals Plymouth NHS Trust) Mariam Rela
- Pedrazzani Corrado
- Pellino Gianluca
- Pereira Andr\ue9
- Pereira-Neves Ant\uf3nio
- Perez-Diaz Md
- Perivoliotis (General University Hospital of Larissa) Konstantinos
- Perkins Clare
- Perotto (CHU Saint Etienne) Ornella
- Perra Teresa
- Petrone Patrizio
- Phenix George
- Piacenza)
- Picazo Sara
- Picon-Rodriguez Rafael
- Piloni Martina
- Pingarr\uf3n-Mart\uedn Lorena
- Pinotti Enrico
- Pizzini Paolo
- PM de Vries Jean-Paul
- Pockney Peter
- Podolsky Dina
- Poggioli Gilberto
- Pompili Cecilia
- Pontari Michael
- Porcu Alberto
- Portugal: Hugo Santos-Sousa Pakistan: Mariyah Anwer (Jinnah postgraduate medical center).
- Potter (Royal Bournemouth Hospital) Ryan
- Price Claire
- Prita Daliya 8
- Pruvot (Lille University Hospital) Fran\ue7ois-Ren\ue9
- PTSurg ItSURG
- Pujol-Muncunill Roger
- Puppo Andrea
- Q Mehdi (University of Texas Medical Branch) Mohammad
- Quante Markus
- Quintana-Villamandos Bego\uf1a
- Qureshi Ali
- R Burke Joshua
- R Davidson Brian
- R Dixon Jan
- R Fretwell Kenneth
- R Gujjuri Rohan
- R Gujjuri Rohan
- R Kowal Mikolaj
- R O\u2019Neill John
- R Sarma Diwakar
- R Spalding Duncan
- R Springford Laurie
- Rachel Baumber (Royal National Orthopaedic Hospital) James T Parry
- Radenkovic Dejan
- Rahman Saad (Medway Maritime Hospital) Abdel
- Rakvin Ivan
- Ramallo-Sol\ueds Irene
- Ramcharan Sean
- Ramos Diego
- Ramos-Bonilla Antonio
- Ramos-De la Medina Antonio
- Ramzi Joussi
- Rathinam Sridhar
- Rausa Emanuele
- Ravaioli Matteo
- Ravindran Sharanya
- Raymond (Royal Lancaster Infirmary) Thomas
- Razik Aisha
- Redfern (Furness General Hospital) Jennifer
- Reguera-Rosal Julio
- Rey-Biel Juan
- Rey-Valcarcel Cristina
- RG Sheel Andrea
- Ribolla Marta
- Richards Tomos
- Richmond (University of Maryland Medical Center) Michael
- Righini (Ospedale del Delta Erminio
- Rio-Gomez Javier
- Riuniti Villa Sofia-Cervello Ospedali
- Riyat Harjoat
- Rizvi Sana
- Roberts Keith
- Roberts Matthew
- Robertson (University Hospitals Coventry and Warwickshire) Stuart
- Robertson (University of Arkansas for Medical Sciences) Ronald
- Robin-Valle Alvaro
- Rochon Melissa
- Rojo Mikel
- Rolli Luigi
- Romano Silvio
- Rome)
- Romford)
- Ross Elizabeth
- Ross Howard
- Rottoli Matteo
- Royal Hospital) Princess
- Ruiz (Hospital General Universitario Reina Sof\ueda Miguel
- Ruiz- Grande Fernando
- Ruiz-Martin (Rey Juan Carlos University Hospital) Irene
- Ruiz-Soriano (Hospital Cl\uednico Universitario de Valladolid) Mar\ueda
- Ruzzenente Andrea
- Ryska Ondrej
- S Abdelaal (Alexandria Main University Hospital) Ahmed
- S Al Maadany Faraj
- S Faria Carlos
- S Hammond John
- S Hossain Fahad
- S Jeyaretna Deva
- S Jones Conor
- S Khan (Queen Alexandra Hospital) Jim
- S Moura Francisco
- S Ng-Kamstra Joshua
- S Sica Giuseppe
- S Tamimy Muhammad
- S Wadley Martin
- S\ue1nchez- Arteaga Alejandro
- SA Taher Ahmed
- Saez Carlos
- Sahnan Kapil
- Sahni Arun
- Salim Ali
- Salvia Roberto
- Sammarco Giuseppe
- Sampaio-Alves Mafalda
- San Miguel-Mendez Carlos
- Sanchez del Pueblo Cristina
- Sanchez-Fuentes Maria-Nieves
- Sanchez-Pelaez Daniel
- Sanchez-Perez Coral
- Sanchez-Rubio Maria
- Sancho-Muriel Jorge
- Sanchon Fructuoso Lorena
- Sanders Julie
- Santero-Ramirez Maria-Pilar
- Santora Thomas
- Santoro Antonio
- Santos Irene
- Sapienza Paolo
- Sartarelli (Sant\u2019Orsola Hospital Lodovico
- Sarveswaran Janahan
- Sasia Diego
- Sassari) A. O. U.
- Saudemont Alain
- Saudi-Moro Sef
- Saxena Dolly
- Saxena Shobhit
- Sayasneh Ahmad
- Scalabre Aurelien
- Schache Andrew
- Schiavina Riccardo
- Schineis (Charit\ue9 University Medicine Christian
- Schreckenbach Teresa
- Scorza Antonella
- Scott Lucy
- Seegert (ProMedica Toledo Hospital) Sara
- Seguin-Givelet Agathe
- Senent-Boza Ana
- Serrano Gonz\ue1lez Javier
- Sette Laghi Asst
- Seymour Keith
- Shabana Amanda
- Shah (The Whittington Hospital) Sujay
- Shah Jigar
- Shah Karishma
- Shah Preena
- Shakir Taner
- Shalaby (Mansoura University Hospital) Mostafa
- Shankar (Oxford University Hospitals NHS Foundation Trust Sushma
- Shaw Richard
- Sheffield)
- Shehata Sameh
- Shelley Hwang E.
- Shen Ban Vin
- Shenfine Amy
- Sheridan Kelda
- Sherief Ahmed
- Sherif Mohamed
- Shinkwin Michael
- Shu Sebastian
- Siaw-Acheampong Kwabena
- Sileri (San Raffaele Scientific Institute Pierpaolo
- Singh Abhinav
- Singh Shailendra
- Sinha Sanjay
- Siragusa (Policlinico Tor Vergata Hospital Leandro
- Sivaprakasam Rajesh
- Sivayoganathan Sriharan
- SJ Ledesma Frances
- Smillie Robert
- Smith (Countess of Chester Hospital) Claire
- Smith Andrew
- Smith Christopher
- Sochorova (Royal Liverpool University Hospital) Dana
- Society of Coloproctology (ESCP) European
- Society of Colorectal Surgery (SICCR) Italian
- Soggiu Fiammetta
- Sohrabi (St Bartholomew's Hospital) Catrin
- Sohrabi (Whipps Cross University Hospital) Catrin
- Sohrabi Catrin
- Solari (Royal Gwent Hospital) Francesca
- Solli Piergiorgio
- Soreide Kjetil
- Soto Montesinos Cristina
- SpainSurg
- Spinelli Antonino
- Spinelli Antonino
- Spoletini (Sant'Eugenio Hospital) Domenico
- Spriano Giuseppe
- Sravanam Sanskrithi
- Ssentongo (Pennsylvania State University) Paddy
- Stanger Sophie
- Stavroulias Dionisios
- Steel (Sunderland Royal Hospital) Ben
- Stella Marco
- Stewart Robbie
- Stringer Sally
- Sudan: Osman M Ali Elima P Cagigal- Ortega (Hospital Universitario Severo Ochoa).
- Sulen Nina
- Sundar Sudha
- Sundhu (Aintree University Hospital) Matthew
- Surgical Research Collaborative (ISRC) Irish
- Suri (University of California Davis Health Avni
- Swansea)
- Switzerland: Dimitri Christoforidis Ali A Ali karar (Al-rajhi).
- Syed Arooj
- Szatmary Peter
- T Colonna Emily
- T Enjuto Diego
- T Montella (Azienda Unit\ue0 Sanitaria Locale-IRCCS di Reggio Emilia) Maria
- TA Neely David
- Tabiri Stephen
- Tadross Daniel
- Taglietti Lucio
- Tansey (Princess Alexandra Hospital) Rosamond
- Tartaglia Dario
- Tawheed (Endemic Medicine Department Ahmed
- Tayeh Salim
- Testa Valentina
- Tewari Nilanjana
- Thoenissen Philipp
- Thomas (Worcestershire Acute Hospitals NHS Trust) Kane
- Thrush Jessica
- Tierney Sean
- Tiwari Abhinav
- Tobias Teles (Hospital de Cascais - Dr. Jos\ue9 de Almeida) Pedro A Serralheiro
- Toledo Enrique
- Tonini Valeria
- Torkington Jared
- Torzilli Guido
- Totty Joshua
- Tousidonis Manuel
- Townend Philip
- Townsend Catherine
- Trompeter (St George's Hospital) Alex
- Trotta Francesco
- Truant St\ue9phanie
- Trujillo-D\uedaz Jeancarlos
- Tsoulfas George
- Tsoulfas Georgios
- Turco Celia
- Turkey: Volkan Ozben Georgios Peros (Kantonsspital Winterthur).
- Turrado- Rodriguez Victor
- Turri Giulia
- Tustin (Cumberland Infirmary) Harry
- Tyler Jayne
- Tzedakis Stylianos
- Tzovaras George
- Ullah Ramzan
- Unit\ue0 Sanitaria Locale di Ferrara Azienda
- United Kingdom: Richard J Davies Alp Yildiz (Yildirim Beyazit University Yenimahalle Training and Research Hospital).
- United States: John RT Monson (AdventHealth Orlando) Lavinia Onos (York Teaching Hospitals NHS Trust).
- University Hospitals NHS Trust) Nottingham
- University of Rome) Sapienza
- University) Goethe
- University) Helwan
- Urban (University of Colorado Hospital) Shane
- Urbani (Azienda Ospedaliero Universitaria San'Anna Alessia
- Usai Antonella
- V Bhavaraju Avi
- V Comini Lara
- V Feo Carlo
- V Marino Marco
- V Shaw Abigail
- V\ue1zquez- Fern\ue1ndez Andrea
- Vaccarella (Azienda Ospedaliera Gianpaolo
- Valdes- Hernandez Javier
- Valsecchi Luca
- Vashisht Rajiv
- VCO) Asl
- Venkatesan (Glan Clwyd Hospital) Gowtham
- Vera-Mansilla Cristina
- Vergari (Ospedali Riuniti di Ancona) Roberto
- Vescio (University 'Magna Graecia' of Catanzaro) Giuseppina
- Vidya Raghavan
- Vieira (Centro Hospital Universit\ue1rio S\ue3oJo\ue3o) Paula
- Vijay Vardhini
- Vimalachandran Dale
- Vimalachandran Dale
- Violante Tommaso
- Vovola Fernanda
- Vulliamy Paul
- W Endorf (Hennepin Healthcare) Frederick
- W Etchill Eric
- W L\uf6ffler Markus
- W L\uf6ffler Markus
- Wall Rosemary
- Wallwork Kate
- Ward Alex
- Warwick (University Hospital Southampton) David
- Waseem Saima
- Weaver Helen
- Wells Fiona
- Wen Jiaxin
- West Raha
- Whitehall Emma
- Wild Laura
- Wilkins Alex
- Williams Gethin
- Williams Matthew
- Winnand (University Hospital Aachen) Philipp
- Wong (Addenbrooke's Hospital) Ken
- Worku (Queen\u2019s Medical Centre Dawit
- Wright Naomi
- WS Ho (Leeds Teaching Hospitals NHS Trust Michael
- WT Ngu Albert
- y Cajal) Cristina Cerro (Hospital Universitario Ram\uf3n
- Y Oo (Department of Cardiothoracic Surgery Aung
- y Polit\ue9cnico La Fe) Blas Flor (Hospital Universitario
- Y van der Plas Willemijn
- Yalamanchili Seema
- Yershov (South Warwickshire NHS Foundation Trust) Danylo
- Young Richard
- Yousra Ahmed (Portsmouth Hospital NHS Trust) Simon Toh
- Yurttas Can
- Zadegan Frederic
- Zafar (Northwick Park Hospital) Noman
- Zakaria Rasheed
- Zambon Martina
- Zanini Nicola
- ZE Durst Alexander
- Zerbib Philippe
- Zonta (Ospedale San Biagio Sandro
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2020
- Field of study
Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research
The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance
- Author
- Aanniz Tarek
- Abar Aden Elmi
- Abbad Anass
- Abdelfattah May
- Abdelhamid W.
- Abdella Saro
- Abdellah Faouzi
- Abdelmjid El Oualid
- Abdelmoula Fatma
- Abdelmoulah F.
- Abderrahmane Maaroufi
- Abderrazak Rfaki
- Abdillahi Idil Salah
- Abdissa Alemseged
- Abdo I.
- Abdoelraheem Mohamed Hassan
- Abe Haruka
- Abebe Markos
- Abechi Priscilla
- Abera Adugna
- Abi Rachid
- Abias Abe G.
- Abichu Getachew
- Abid N.
- Abid Nabil
- Abid Salma
- Abilio Nuro
- Abimbola Sharon
- Abo Shama Noura M
- Abosede O.
- Aboubaker Mohamed Houmed
- Abouelhoda Mohamed
- Abouelnaga S.
- Abualas Elamin
- Abubeker Ramalia Chabi
- Abuelenein Ehab Abdelkader
- Abuzaid Nadir
- Abworo Edward O.
- Ada Diosdado Odjama Nseng
- Addidle Michael
- Adegbola Richard
- Adegnika Akim A.
- Adegnika Ayola Akim
- Adel Abd Monaem
- Adeniji Johnson A.
- Adepetun Tomiwa
- Adesegun A.
- Adesuyi Omoare
- Adetifa Ifedayo M. O.
- Adewumi Olubusuyi M.
- Adewumi Oluwatimilehin
- Adewumi Praise
- Adeyemi Kayode T.
- Adhikari Bishwo N.
- Adil El Hamouchi
- Adjiratou Aissatou B. A.
- Adnew Bethlehem
- Adu Bright
- Adu Eric
- Adusei-Poku Mildred
- Agbenyo Seyram Bless
- Agbodzi B.
- Ageez A.M.
- Agoti Charles N.
- Aguenaou Hassan
- Agwa Sara Hassan
- Agweyu Ambrose
- Ahmed El Bara
- Ahmed Elhadi A.
- Ahmed Hatem
- Ahmed M.
- Ahmed O. S.
- Ahmed Rahma
- Ahmed Shymaa S.
- Ahmed Side Mohamed
- Ahmed Yahaya Ali
- Ahouidi Ambroise
- Ahuka-Mundeke Steve
- Ahumibe Anthony
- Ahyong Vida
- Aissam El Aliani
- Ajayi Nnennaya A.
- Ajibaye Solomon
- Ajili F.
- Ajogbasile F.V.
- Ajogbasile Fehintola V.
- Akanbi Olusola Anuoluwapo
- Akenji Blaise MBoringong
- Akhoud Youssef
- Akinola Monilade
- Akogbeto Petas
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- Alemayehu Dawit Hailu
- Alemu Fekadu
- Algheriani Raiva
- Ali Abraham
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- Ali Mohamed Ahmed
- Ali Mushal
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- Alkarim Mona O.A.
- Allam Loubna
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- Crespin Xavier
- Cá Milanca Agostinho
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- Diop Mamadou
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- Djomsi Dowbiss Meta
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- Fares Wasfi
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- Fedorov A.V.
- Fekkak Jamal
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- Gevao Sahr
- Gharmaz Hamza
- Ghassan Adib
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- Gideon Nsubuga
- Giordani F.
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- Hosch Salome
- Houda Harmak
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- Houhamdi Linda
- Hounkanrin Gildas
- Hounkpatin Benjamin
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- Iwalokun Bamidele
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- Jain Komal
- Jalal D.
- Jalal Nourlil
- Jalloh Simbirie
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- Jannoo N.
- Jefferies Sarah
- Jegede-Williams Anu
- Jelly Lauren
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- Johane Shirley
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- Joloba Moses
- Joseph Rageema
- Jouali Farah
- Jumaa A.B.
- Juru Agnes
- Kabamba Gabriel
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- Kabatesi Francisca
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- Kandeil Ahmed
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- Kane Mouhamed
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- Kanjerwa Oscar
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- Lahlou Amine Idriss
- Lahlou Idriss-Amine
- Lahlou Kitane Driss
- Lako Richard Lino Loro
- Lalemi Mary
- Lambisia Arnold W.
- Lamboni Lallepak
- Lamiae Belayachi
- Langat Sombo
- Laraqui Abdelilah
- Laryea Dennis
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- Lee Justin
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- Lefrançois Louise
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- Lell Bertrand
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- Lin L.
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- Lista F.
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- Lo Gora
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- Lockman Shahin
- Lodiongo Dennis Kenyi
- Lojuan Abe
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- Long Kyle A.
- Lontchi Roméo Aimé Laclong
- Lorenzo-Redondo Ramy
- Loucoubar Cheikh
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- Lutalo Tom
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- Maiga Mamoudou
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- Maloum Moustapha Nzamba
- Maluzi Kwitaka
- Maman Issaka
- Manangazira Portia
- Mancon Alessandro
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- Manga Pasacaline
- Manickchund N.
- Manneh Jarra
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- Manouana Gédéon Prince
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- Maqsood Rachel
- Marais Gert
- Marcello Alessandro
- Mareka Mathabo
- Margaglione Maurizio
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- Marie Claire Okomo Assoumou
- Marion Amujal
- Maritz Jean
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- Marondera Blessing T.
- Marti-Carerras Joan
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- Maruapula Dorcas
- Marx Jacques
- Marycelin Baba
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- Massinga Arsenia
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- Mathur H.
- Matobo Mooko Marethabile
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- Matsheka Maitshwarelo I.
- Maufrais Corinne
- Mavingui Patrick
- Mayaphi Sim
- Mayor Alfredo
- Maïté Soundélé
- Mba Nwando
- Mbala Placide K.
- Mbanne Maimouna
- Mbaye Aminata
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- Waberi Zeinab Ali
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- Wang Jing
- Wang Xiuhua
- Wani Gregory
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- Wawina-Bokalanga Tony
- Wayengera Misaki
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- Webby R.
- Webby Richard
- Weldemariam A.G.
- Weldemariam Atsbeha G.
- Werno Anja
- Wiley Michael R.
- Wilkinson David
- Wilkinson Eduan
- Williamson Carolyn
- Wilson Shannon
- Woelfel R.
- Wohl Shirlee
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- Wolter Nicole
- Wuduri Zara
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- Xiang Zuzheng
- Xie Hong
- Yadouleton Anges
- Yadouleton Yahya
- Yakout Mostfa
- Yandoko Rivalyn Nakoune
- Yang Qi
- Yao Kouadio T.
- Yassine Kasmi
- Yassine Zouheir
- Yasuda Jiro
- Yatassaye Bouna
- Yeboah C.
- Yeboah Richmond
- Yeboah-Manu Dorothy
- Yemi Bright K.
- Yiaba Cyrus
- Yiaba Warren Cyrus
- Yu Popova A.
- Yusuf Nyam Itse
- Yusuf Yacob Mohamed
- Zablon J. Matoke D.
- Zablon J.O.
- Zaher Tarek Refaat Elnagdy Raafat
- Zahra El Ansari Fatima
- Zahran Manal Hamdy
- Zekri Abdel-Rahman N.
- Zhang J.
- Zhou Pei
- Zinyowera Sekesai
- Zong Minko O.
- Zongo Arsène
- Zorgani A.
- Zouaki Amal
- Zulu P.
- Zumla Ali
- Zumla Alimuddin
- Zuze Boitumelo
- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 07/10/2022
- Field of study
INTRODUCTION
Investment in Africa over the past year with regard to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing has led to a massive increase in the number of sequences, which, to date, exceeds 100,000 sequences generated to track the pandemic on the continent. These sequences have profoundly affected how public health officials in Africa have navigated the COVID-19 pandemic.
RATIONALE
We demonstrate how the first 100,000 SARS-CoV-2 sequences from Africa have helped monitor the epidemic on the continent, how genomic surveillance expanded over the course of the pandemic, and how we adapted our sequencing methods to deal with an evolving virus. Finally, we also examine how viral lineages have spread across the continent in a phylogeographic framework to gain insights into the underlying temporal and spatial transmission dynamics for several variants of concern (VOCs).
RESULTS
Our results indicate that the number of countries in Africa that can sequence the virus within their own borders is growing and that this is coupled with a shorter turnaround time from the time of sampling to sequence submission. Ongoing evolution necessitated the continual updating of primer sets, and, as a result, eight primer sets were designed in tandem with viral evolution and used to ensure effective sequencing of the virus. The pandemic unfolded through multiple waves of infection that were each driven by distinct genetic lineages, with B.1-like ancestral strains associated with the first pandemic wave of infections in 2020. Successive waves on the continent were fueled by different VOCs, with Alpha and Beta cocirculating in distinct spatial patterns during the second wave and Delta and Omicron affecting the whole continent during the third and fourth waves, respectively. Phylogeographic reconstruction points toward distinct differences in viral importation and exportation patterns associated with the Alpha, Beta, Delta, and Omicron variants and subvariants, when considering both Africa versus the rest of the world and viral dissemination within the continent. Our epidemiological and phylogenetic inferences therefore underscore the heterogeneous nature of the pandemic on the continent and highlight key insights and challenges, for instance, recognizing the limitations of low testing proportions. We also highlight the early warning capacity that genomic surveillance in Africa has had for the rest of the world with the detection of new lineages and variants, the most recent being the characterization of various Omicron subvariants.
CONCLUSION
Sustained investment for diagnostics and genomic surveillance in Africa is needed as the virus continues to evolve. This is important not only to help combat SARS-CoV-2 on the continent but also because it can be used as a platform to help address the many emerging and reemerging infectious disease threats in Africa. In particular, capacity building for local sequencing within countries or within the continent should be prioritized because this is generally associated with shorter turnaround times, providing the most benefit to local public health authorities tasked with pandemic response and mitigation and allowing for the fastest reaction to localized outbreaks. These investments are crucial for pandemic preparedness and response and will serve the health of the continent well into the 21st century
Bee chitosan nanoparticles loaded with apitoxin as a novel approach to eradication of common human bacterial, fungal pathogens and treating cancer
- Author
- Publication venue
- Frontiers Media S.A.
- Publication date
- 01/03/2024
- Field of study
Antimicrobial resistance is one of the largest medical challenges because of the rising frequency of opportunistic human microbial infections across the globe. This study aimed to extract chitosan from the exoskeletons of dead bees and load it with bee venom (commercially available as Apitoxin [Api]). Then, the ionotropic gelation method would be used to form nanoparticles that could be a novel drug-delivery system that might eradicate eight common human pathogens (i.e., two fungal and six bacteria strains). It might also be used to treat the human colon cancer cell line (Caco2 ATCC ATP-37) and human liver cancer cell line (HepG2ATCC HB-8065) cancer cell lines. The x-ray diffraction (XRD), Fourier transform infrared (FTIR), and dynamic light scattering (DLS) properties, ζ-potentials, and surface appearances of the nanoparticles were evaluated by transmission electron microscopy (TEM). FTIR and XRD validated that the Api was successfully encapsulated in the chitosan nanoparticles (ChB NPs). According to the TEM, the ChB NPs and the ChB NPs loaded with Apitoxin (Api@ChB NPs) had a spherical shape and uniform size distribution, with non-aggregation, for an average size of approximately 182 and 274 ± 3.8 nm, respectively, and their Zeta potential values were 37.8 ± 1.2 mV and − 10.9 mV, respectively. The Api@ChB NPs had the greatest inhibitory effect against all tested strains compared with the ChB NPs and Api alone. The minimum inhibitory concentrations (MICs) of the Api, ChB NPs, and Api@ChB NPs were evaluated against the offer mentioned colony forming units (CFU/mL), and their lowest MIC values were 30, 25, and 12.5 μg mL−1, respectively, against Enterococcus faecalis. Identifiable morphological features of apoptosis were observed by 3 T3 Phototox software after Api@ChB NPs had been used to treat the normal Vero ATCC CCL-81, Caco2 ATCC ATP-37, and HepG2 ATCC HB-8065 cancer cell lines for 24 h. The morphological changes were clear in a concentration-dependent manner, and the ability of the cells was 250 to 500 μg mL−1. These results revealed that Api@ChB NPs may be a promising natural nanotreatment for common human pathogens
The Anti-Rheumatic Drug, Leflunomide, Induces Nephrotoxicity in Mice via Upregulation of TGFβ-Mediated p53/Smad2/3 Signaling
- Author
- Publication venue
- MDPI AG
- Publication date
- 01/05/2022
- Field of study
Recent studies indicated renal toxicity and interstitial nephritis in patients receiving leflunomide (LEFN), but the exact mechanism is still unknown. The transforming growth factor β (TGFβ)/p53/Smad2/3 pathway crucially mediates renal fibrosis. We aimed to assess the nephrotoxic effect of LEFN in mice and the possible role of TGFβ-stimulated p53/SMAD2/3 signaling. The study design involved distributing sixty male albino mice into four groups: (i) vehicle-treated mice, (ii) LEFN (2.5 mg/kg), (iii) LEFN (5 mg/kg), and (iv) LEFN (10 mg/kg). The drug was given orally every 48 h and continued for 8 weeks. Blood samples were then taken from mice for the determination of kidney function parameters. Right kidneys were used for histopathologic staining and immunohistochemistry, whereas left kidneys were frozen and used for Western blot analysis of the target proteins, p-p53 and Smad2/3. Results indicated that chronic administration of LEFN in mice resulted in a four- and nine-fold increase in serum urea and creatinine levels, respectively. Kidney specimens stained with hematoxylin and eosin or periodic acid–Schiff showed significant histopathological manifestations, such as cellular irregularity, interstitial congestion, and moderate lymphocytic inflammatory infiltrate in mice treated with LEFN. Western blotting indicated upregulation of the p-p53/Smad2/3 proteins. LEFN, especially in the highest dose (10 mg/kg), produced prominent nephrotoxicity in mice. This toxicity is mediated through stimulating fibrotic changes through TGFβ-stimulated p53/Smad2/3 signaling and induction of glomerular and tubular apoptosis. An improved understanding of LEFN-induced nephrotoxicity would have great implications in the prediction, prevention, and management of leflunomide-treated rheumatic patients, and may warrant further clinical studies for following up these toxidromes
Data_Sheet_1_Bee chitosan nanoparticles loaded with apitoxin as a novel approach to eradication of common human bacterial, fungal pathogens and treating cancer.docx
- Author
- Publication venue
- Publication date
- 15/03/2024
- Field of study
Antimicrobial resistance is one of the largest medical challenges because of the rising frequency of opportunistic human microbial infections across the globe. This study aimed to extract chitosan from the exoskeletons of dead bees and load it with bee venom (commercially available as Apitoxin [Api]). Then, the ionotropic gelation method would be used to form nanoparticles that could be a novel drug-delivery system that might eradicate eight common human pathogens (i.e., two fungal and six bacteria strains). It might also be used to treat the human colon cancer cell line (Caco2 ATCC ATP-37) and human liver cancer cell line (HepG2ATCC HB-8065) cancer cell lines. The x-ray diffraction (XRD), Fourier transform infrared (FTIR), and dynamic light scattering (DLS) properties, ζ-potentials, and surface appearances of the nanoparticles were evaluated by transmission electron microscopy (TEM). FTIR and XRD validated that the Api was successfully encapsulated in the chitosan nanoparticles (ChB NPs). According to the TEM, the ChB NPs and the ChB NPs loaded with Apitoxin (Api@ChB NPs) had a spherical shape and uniform size distribution, with non-aggregation, for an average size of approximately 182 and 274 ± 3.8 nm, respectively, and their Zeta potential values were 37.8 ± 1.2 mV and − 10.9 mV, respectively. The Api@ChB NPs had the greatest inhibitory effect against all tested strains compared with the ChB NPs and Api alone. The minimum inhibitory concentrations (MICs) of the Api, ChB NPs, and Api@ChB NPs were evaluated against the offer mentioned colony forming units (CFU/mL), and their lowest MIC values were 30, 25, and 12.5 μg mL−1, respectively, against Enterococcus faecalis. Identifiable morphological features of apoptosis were observed by 3 T3 Phototox software after Api@ChB NPs had been used to treat the normal Vero ATCC CCL-81, Caco2 ATCC ATP-37, and HepG2 ATCC HB-8065 cancer cell lines for 24 h. The morphological changes were clear in a concentration-dependent manner, and the ability of the cells was 250 to 500 μg mL−1. These results revealed that Api@ChB NPs may be a promising natural nanotreatment for common human pathogens.</p
Global economic burden of unmet surgical need for appendicitis
- Author
- A A Essam
- Abd El-Rahman Hegazy Khedr
- Abd Elkhalek Sallam
- Abd Elrahman Elshafay
- Abdalla Gamal Saad
- Abdalla Gharib
- Abdalla Kenibar
- Abdallah Salah Elsherbiny
- Abdalrahman Adel
- Abdelaziz Abdelaal
- Abdelaziz Osman Abdelaziz Elhendawy
- Abdelfatah Hussein
- Abdelkader Belkouchi
- Abdelmalek Hrora
- Abdelrahman Adelshone
- Abdelrahman Alkammash
- Abdelrahman Assal
- Abdelrahman Geuoshy
- Abdelrahman Haroun
- Abdelrahman Mohammed
- Abdelrahman Sayed
- Abdelrahman Soliman
- Abdelrhman Essam Elnemr
- Abdelrhman Kz Darwish
- Abdelrhman Osama Elsebaaye
- Abdul Khalique
- Abdul Rehman Alvi
- Abdul Wahid Anwar
- Abdulaziz Altwijri
- Abdullah Al-Mallah
- Abdullah Almoflihi
- Abdullah Altamimi
- Abdullah Daqeeq
- Abdullah Dwydar
- Abdullah Gouda
- Abdullah Hashim
- Abdulmalik Altaf
- Abdulmalik Huwait
- Abdulrahman Abdel-Aty
- Abdulrahman M Altwigry
- Abdulrahman Sheshe
- Abdulrasheed A Nasir
- AbdulRazzaq Oluwagbemiga Lawal
- Abdulshafi Khaled Abdrabou
- Abdurrahaman Sheshe
- Abdussemiu Abdurrazzaaq
- Abebe Bekele Zerihun
- Abeer Al-Shammari
- Abeer El Gendy
- Abeer Esam
- Abeer Marey
- Abhishek Mittal
- Abiboye Yifieyeh
- Abid Bin Mahamood
- Abidemi Adesuyi
- Abouelatta Khairy Aly
- Abrar Nawawi
- Adam Gyedu
- Ade Waterman
- Adedapo Osinowo
- Adedeji Fatuga
- Adel Albiety
- Adel B Hassanein
- Adel Denewar
- Adeleke Adekoya
- Ademola Adebanjo
- Ademola Adeyeye
- Ademola Popoola
- Adesina Adedeji
- Adesoji O Ademuyiwa
- Adesoji Tade
- Adewale Adeniyi
- Adewale O Adisa
- Adham Tarek
- Adomas Ladukas
- Adrian F Palma
- Afifatun Hasanah
- Afizah Salleh
- Afnan Abdelfatah
- Afnan Altamimi
- Afnan Altamini
- Agazi Fitsum
- Agboola Taiwo
- Ahamed Hassan
- Ahed Ghaben
- Ahmad Abdel Fattah
- Ahmad Abdel Razaq Al Rafati
- Ahmad Aboelkassem Ibrahem
- Ahmad Aldalaq
- Ahmad Ali
- Ahmad Almallah
- Ahmad Alrifaie
- Ahmad Ashour
- Ahmad Bakr
- Ahmad Bani-Sadar
- Ahmad Bin Adnan
- Ahmad Elbatahgy
- Ahmad Faraz
- Ahmad Gudal
- Ahmad Hasan
- Ahmad Khaled Sabe
- Ahmad Khoja
- Ahmad Nashaat
- Ahmad Qaissieh
- Ahmad Sabe
- Ahmad Saber Sleem
- Ahmad Sakr
- Ahmad Shalabi
- Ahmad Uzair Qureshi
- Ahmed Aamer
- Ahmed Abd El Galeel
- Ahmed Abd Elmoen Elhusseiny
- Ahmed Abd Elsameea
- Ahmed Abdelkareem
- Ahmed Abdelmotaleb Ghazy
- Ahmed Abo El Magd
- Ahmed Abo Elazayem
- Ahmed Adamu
- Ahmed Adel
- Ahmed Afandy
- Ahmed Ahmed
- Ahmed Al-Khatib
- Ahmed Alghamdi
- Ahmed Ali
- Ahmed Altibi
- Ahmed Alzahrani
- Ahmed Ata
- Ahmed Badr
- Ahmed Dahy
- Ahmed Diab
- Ahmed El Kashash
- Ahmed El Kholy
- Ahmed El-Sehily
- Ahmed Elgaili Khalid Musa
- Ahmed Elgebaly
- Ahmed Elkelany
- Ahmed Elkholy
- Ahmed Essam
- Ahmed Fahiem
- Ahmed Farag
- Ahmed Fawzy
- Ahmed Fouad
- Ahmed Gad
- Ahmed Ghanem
- Ahmed Gheith
- Ahmed Gomaa
- Ahmed Hafez El-Badri Kotb
- Ahmed Hammad
- Ahmed Hassan
- Ahmed Hossam Eldin Fouad Rida
- Ahmed Ismail
- Ahmed Karim
- Ahmed Khyrallh
- Ahmed Lasheen
- Ahmed M Rashed
- Ahmed Magdy
- Ahmed Mahmoud Abdelraouf
- Ahmed Menshawy
- Ahmed Meshref
- Ahmed Mohamed Afifi
- Ahmed Mohamed Ibrahim
- Ahmed Mohameden
- Ahmed Mohammed
- Ahmed Mokhtar
- Ahmed Mosad
- Ahmed Moustafa
- Ahmed Moustafa Saeed
- Ahmed Negida
- Ahmed Rabeih Mohammed
- Ahmed Rabie Mohamed
- Ahmed Ragab Nayel
- Ahmed Ragab Soliman
- Ahmed Raslan
- Ahmed Raza
- Ahmed Refaat
- Ahmed Rslan
- Ahmed Sabry
- Ahmed Sabry El-Hamouly
- Ahmed Safwan Marey
- Ahmed Saidbadr
- Ahmed Sakr
- Ahmed Samir
- Ahmed Shahine
- Ahmed Sheta
- Ahmed Soliman
- Ahmed Tammam
- Ahmed Tarek Abdelbaset Hassan
- Ahmed W Shamsedine
- Ahmed Zaki
- Ahmed Zaki Eldeeb
- Ahmed Zohair
- Ahmedali M Kandil
- Ahmedglal Elnagar
- Ahsan Zil-E-Ali
- Aijaz Jabbar
- Ailsa Claire Snaith
- Ainhoa Costas-Chavarri
- Aiste Austraite
- Ajayesh Mistry
- Akin Olaolorun
- Akinlabi E Ajao
- Al Faifi Jubran
- Ala Shamasneh
- Alaa Abouelnasr
- Alaa Al-Buhaisi
- Alaa Bowabsak
- Alaa El Jamassi
- Alaa Elazab
- Alaa Elhadad
- Alaa Fergany
- Alaa Habeebullah
- Alaa Hassan
- Alaa Shabkah
- Alaa Shaheen
- Alaba Adesina
- Alan Baird
- Alan Grant
- Alasdair Ball
- Alban Cacurri
- Albert Mohale Mphatsoe
- Alberto Realis Luc
- Alejandro Matheu
- Alejandro Munera
- Alemayehu Ginbo Bedada
- Alessandro Favero
- Alessio Maniscalco
- Alexander Canta Calua
- Alexander J Fowler
- Alexandra Gerosa
- Alexandre Horobjowsky
- Alexandre Venancio De Sousa
- Alexia Farrugia
- Alexis Pierre Arnaud
- Alfio Alessandro Russo
- Alfredo Gulielmi
- Ali Ababneh
- Ali Abo El Dahab
- Ali Amin Ahmed Ata
- Ali Khan Niazi
- Ali Kiasat
- Ali Mohamed Hammad
- Ali Zardab
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- Aline Broch
- Alireza Hasheminia
- Alisdair Macdonald
- Aliyu Ndajiwo
- Allan Novak
- Alphonse Zeta Mutabazi
- Alvaro Enrique Mendoza Beleño
- Alvin Ee Zhiun Cheah
- Aly Abd Elrazek
- Aly Nasr
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- Alyne Daltri Lazzarini Cury
- Amal Ibrahim
- Amandine Martin
- Amani Althwainy
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- Amar Kourdouli
- Amel Hashish
- Amerdip Birring
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- Amina Abdelhamid
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- Aminu Mohammad
- Amir Ait Kaci
- Amira Atef Omar
- Amira Elsawy
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- Amira Reda
- Amjad Abu Qumbos
- Amjad Elmashala
- Ammar Gado
- Amna Mamdouh Mohamed
- Amna Mohamed
- Amoudtha Rasendran
- Amr Ahmed Saleh
- Amr Fadel
- Amr Hasan
- Amr Hassaan
- Amr Hossameldin
- Amr Muhammad Elkorashy
- Amr Tarek Hafez
- Amreen Faruq
- Amro Aglan
- Ana Cecilia Manchego Bautista
- Ana Lucia Contreras-Vergara
- Ana Maria Sandoval Barrantes
- Ana Vega Carreiro De Freitas
- Ana Vega Freitas
- Anam Rashid
- Anan Rady Abdelazeam
- Anand Kirishnan
- Anass Majbar
- Anastasia Bamicha
- Anastasios Stefanopoulos
- Anders Thorell
- Andre Das
- Andre Dubois
- Andre L Mihaljevic
- Andre Navarro
- Andrea Allegri
- Andrea Armellini
- Andrea Belli
- Andrea Bondurri
- Andrea Echevarria Rosas Moran
- Andrea Natili
- Andrea Ruzzenente
- Andrea Simioni
- Andreass Haloho
- Andrei Tanase
- Andrej Kolosov
- Andrejus Subocius
- Andrew G N Robertson
- Andrew Kirby
- Andrew Mcguigan
- Andrew Spina
- Andrey Litvin
- Andrius Burmistrovas
- Andrius Strazdas
- Andy Arenas
- Aneel Bhangu
- Anele Rudzenskaite
- Angel David Pérez Rojas
- Angela Dell
- Angelica Genoveva Vergara Mejia
- Angeline Charles
- Angelo Antoniozzi
- Angelo Benevento
- Angelos Tselos
- Angham Solaiman El-Ma'doul
- Anjana Sreedharan
- Ankur Bhatnagar
- Ann Kjellin
- Anna Lasek
- Anna Maffioli
- Anna Powell
- Anna Rinaldi
- Anna Watts
- Annalisa Lo Conte
- Annamaria Bigaran
- Annelisse Ashton
- Annisa Dewi Fitriana Mukin
- Antanas Gulbinas
- Antanas Zadoroznas
- Anthonius Santoso Rulie
- Anthony Ajiboye
- Anthony Avoka
- Anthony Chuk-Him Lai
- Anthony Davor
- Anthony Sander
- Antje Oosterkamp
- Antoinette Bediako-Bowan
- Antonella La Brocca
- Antonio Nocito
- Antonio Ramos-De La Medina
- Antonio Taddei
- Antônio Leal
- Anwar Atiyeh
- Anyomih Theophilus Teddy Kojo
- Aoife Driscoll
- Apar Shah
- Apostolos Vlachogiorgos
- April Camilla Roslani
- Aram Abdelhaq
- Arazzelly Del Pilar Paucar
- Arcangelo Picciariello
- Areej Tarek
- Arezo Kanani
- Ari Leppäniemi
- Arianna Birindelli
- Arij Ibrahim
- Arjun Nesaratnam
- Arlindawati Suyadi
- Armando José Román Velásquez
- Arnaud Bonnard
- Arnav Agarwal
- Aroub Alkaaki
- Arturas Vaicius
- Arvin Khamajeet
- Arvo Reinsoo
- Arwa Abouzaid
- Arwa Elfarargy
- Arwa Ibrahim
- Arwa Mohamed
- Asaf Kedar
- Asdaq Ahmed
- Ased Ali
- Aseel Alnusairat
- Aseel Hamarshi
- Aseel Musleh
- Ash Prabhudesai
- Ashraf A Maghrabi
- Ashraf Morsi
- Ashrarur Rahman Mitul
- Asmaa Abdel-Rahman Al-Aarag
- Asmaa Abdelgelil
- Asmaa Rezq
- Asmaa Salah
- Aspasia Papailia
- Assmaa Badwy
- Astrid Leusink
- Ata Khan
- Ataa Ahmed
- Athanasia Bamicha
- Athar Eysa
- Athirah Zulkifli
- Atif Mahdi
- Attia Attia
- Attia Mohamed Attia
- Audrey Clarissa
- Audrius Dulskas
- Audrius Parseliunas
- Augusto Zani
- Aung Kyaw Tun
- Aurel Mironescu
- Aurel Sandu Mironescu
- Aurelien Scalabre
- Aurora Mariani
- Aurore Haffreingue
- Aurore Thollot
- Ausrine Usaityte
- Austė Skardžiukaitė
- Awais Raza
- Aya Abdel Fatah Ibraheem
- Aya Aboarab
- Aya Adel Elsharkawy
- Aya El-Sawy
- Aya Elwaey
- Aya Firwana
- Aya Hagar
- Aya Hammad
- Aya Mohamed Fathy
- Aya Reda
- Aya Yehia Ata
- Ayah Hamdan
- Ayat Hassaan
- Ayman And Taher
- Ayman Elwan
- Ayman Nabawi
- Ayman Salman
- Ayman Shwky
- Ayokunle Ogunyemi
- Azher Herebat
- Azmina Verjee
- Babajide Adenekan
- Babatunde Odeyemi
- Badr Eldin Adel
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- Bakeer Mohamed
- Bakhtiar Nighat
- Bandar Albeladi
- Barbara Mijuskovic
- Barbara Pereira Silvestre
- Basant Kumar
- Basem Sieda
- Bashir Bello
- Basim Alghamdi
- Basma Magdy
- Basma Mahmoud
- Basmah Alhassan
- Bassant Mowafy
- Beatrice Brunoni
- Beatrix Weber
- Belen Sanchez
- Ben Thompson
- Benoît Parmentier
- Bernard Limoges
- Bernard Van Duren
- Bernhard Wolf
- Bertrand Dousset
- Besmir Grizhja
- Bettina Lieske
- Betty Maillot
- Billal Mansour
- Bjorn Frisk
- Bogdan Diaconescu
- Bogdan-Valeriu Martian
- Boris Marinkovic
- Brendan Skelly
- Brian Cameron
- Britta Dedekind
- Bruno Noukpozounkou
- Bryon Frankie Hon Khi Chong
- Bylapudi Seshu Kumar
- Bárbara Málaga
- Caio Vinícius Barroso de Lima
- Calogero Iacono
- Cameron Fairfield
- Camila Sanchez Samaniego
- Camilla Cona
- Camilo Lopez-Arevalo
- Caoimhe Normile
- Caranj Venugopal
- Carla Cecilia Ramã Rez Cabrera
- Carla Pierina García Torres
- Carlo Corbellini
- Carlos Alejandro Arroyo Basto
- Carlos Iván Pérez Velásquez
- Carlos Morales
- Carlos Nsengiyumva
- Carlos Paz Galvez
- Carmen Capito
- Carmen Fernández
- Carmina Diaz-Zorrilla
- Carolina Guzmán Dueñas
- Carolina Oliveira Felipe
- Caroline Clifford
- Caroluce K Musyoka
- Catherine A Shaw
- Cathy Magee
- Cecile Muller
- Cecilia Costa
- Cecilia Tolg
- Cecilia Wredberg
- Celeste Del Basso
- Cesar Augusto Azmitia Mendizabal
- Cesar Miranda
- Cesar Razuri
- Cezar Ciubotaru
- Chali Chibuye
- Challine Alexandre
- Charing Cheuk Ling Szeto
- Charles Dally
- Charlotte Jane Mcintyre
- Chaymae Benyaiche
- Chean Leung Chong
- Chee Siong Wong
- Cheewei Gan
- Chelise Currow
- Chelsea Deane
- Cheng Chun Goh
- Cherry Koh
- Cheryl Ou Yong
- Chetan Khatri
- Chi Chung Foo
- Chi Ying Jacquelyn Fok
- Chia Kong
- Chiara Ceriani
- Chimwemwe Kwatiwani
- Chingwan Yip
- Chintya Tedjaatmadja
- Choon Seng Chong
- Chouikh Taieb
- Choy Ling Tan
- Chris Bode
- Chris Lee
- Christel Leanne Almanon
- Christian Hinojosa
- Christian Lari Coompson
- Christin Schoewe
- Christina Neophytou
- Christina P Major
- Christina Panteli
- Christine Mizzi
- Christoforos Ferousis
- Christopher Bode
- Christos Agalianos
- Christos Anthoulakis
- Christos Barkolias
- Christos Dervenis
- Chu-Ann Chai
- Chui Yee Wong
- Ciara Fahy
- Cicilia Viany Evajelista
- Cirugia De Emergencia
- Ciskje Zarb
- Citra Dewi Mohd Ali
- Claire Sharpin
- Clara Milagros Herrera Puma
- Clare M Rees
- Clare Morgan
- Claudia Reali
- Claudio Arcudi
- Claudio Fermani
- Claudio Gabriel Fermani
- Clemens Nawara
- Clement Onuoha
- Clodagh Mangan
- Colleen Sampson
- Collins Nwokoro
- Colombani Jean-Francois
- Constantinos Marinos
- Cornelius Mukuzunga
- Corrado Bottini
- Craig Gouldthorpe
- Crislee Elizabeth Lopez
- Cristina Fernandes
- Crystal Yern Nee Chow
- Cutting Edge Manipal
- Céline Grosos
- D C Grobler
- D M Cocker
- Dale Vimalachandran
- Dalia Alkhabbaz
- Dalia Hemeda
- Damien Brown
- Damir Ljuhar
- Dan L Deckelbaum
- Dana Jaradat
- Danelo Du Plessis
- Daniel Ardian Soeselo
- Daniel Cox
- Daniel Dabessa
- Daniel Estuardo Marroquín Rodríguez
- Daniel Hamill
- Daniel Nel
- Daniel Youssef
- Daniela Magri
- Daniele Angelieri
- Daniele Gui
- Danilo Herrera Cruz
- Danjuma Sale
- Dansou Gaspard Gbessi
- Dario Andreotti
- Darius Kazanavicius
- Darragh McCullagh
- David Mcnish
- David Merlini
- David Monterroso Cohen
- Davide De Boni
- Davide Rossi
- Davies Justine
- Dayang Nita Abdul Aziz
- Debora Schivo
- Deborah Chiesa
- Deimante Mikuckyte
- Deividas Dragatas
- Demi Gray
- Diaa Eldin Abdelazeem Amin Elsorogy
- Diaa Moustafa Elbendary Elsawahly
- Diaaaldin Zahran
- Diana Duarte Cadogan
- Diana Sanchez
- Dickson Bandoh
- Diego Alonso Romani Pozo
- Diego Antezana
- Diego Coletta
- Diego Romani
- Diego Sasia
- Dietmar Öfner
- Dieudonne Duhoranenayo
- Dimitri Aristotle Raptis
- Dimitrios Balalis
- Dimitrios K Manatakis
- Dimitrios Karousos
- Dimitrios Korkolis
- Dimitrios Kyziridis
- Dimitrios Lytras
- Dimitrios Papageorgiou
- Dimitrios Sfougaris
- Dimitris-Christos Zachariades
- Dina Al-Marakby
- Dina Faizatur Rahmah
- Dina Gamal
- Dina Tarek
- Dineshwary Periasammy
- Diogo Vinicius Dos Santos
- Dion Morton
- Diya Mirghani
- Djifid Morel Seto
- Dmitri A Raptis
- Dmitri Nepogodiev
- Dmitri Raptis
- Doaa Emadeldin
- Doaa Gamil
- Doaa Hasan
- Doaa Hasanain
- Doaa Maher Abdelrouf
- Domenica Pata
- Domingos Mapasse
- Dominic Charles Marshall
- Donal B O'Connor
- Donatas Danys
- Donatas Venskutonis
- Dorota Radkowiak
- Doug Bowley
- Dovilè Majauskyté
- Dulan Irusha Samaraweera
- Durvesh Lacthman Jethwani
- Dush Iyer
- Dushyant Iyer
- Dzianis Khokha
- Dzmitry Paulouski
- Ebenezer Takyi Atkins
- Echaieb Anis
- Edgar Domini
- Edilberto Temoche
- Eduardo Huaman
- Edvard Grisin
- Edvinas Dainius
- Efeson Thomas
- Egle Preckailaite
- Ehab Alnawam
- Ehab Mamdouh
- Eirik Kjus Aahlin
- Eirini Kefalidi
- Ekow Mensah
- Elaine Borg
- Eldaa Prisca Refianti Sutanto
- Eleanor Marks
- Elena Goldin
- Elena Muzio
- Elena Vendramin
- Elena Zdanyte Sruogiene
- Eleonora Ciccioli
- Elio Jovine
- Elisa Francone
- Elisabeth Jensen
- Elissa Rifhan Mohd Basir
- Elizabeth Snyder
- Ella Teasdale
- Elliot Akoto
- Elodie Gaignard
- Elodie Haraux
- Elsa Robert
- Elsayed Ali
- Elsayed Gamaly
- Emad Abdallah
- Emad Al-Dakka
- Emad Ali Ahmed
- Emad Aljohani
- Emad Mohamed Saeed Taha
- Eman Abd Al Raouf
- Eman Abdelmageed
- Eman Abuqwaider
- Eman Adel Sayma
- Eman Elwy
- Eman Emara
- Eman Hashad
- Eman Ibrahim
- Eman Magdy
- Eman Magdy Hegazy
- Eman Mahmoud Abdulhakeem
- Eman Mohamed Ibrahim
- Eman Mohamed Morshedy
- Eman Nofal
- Eman Rashad
- Eman Yahya Mansor
- Emanuel Barrios
- Emanuele Rausa
- Emeka Nwabuoku
- Emilia De Luca
- Emilie Eyssartier
- Emilio Dijan
- Emma Blower
- Emma Jurdell
- Emma Upchurch
- Emmanuel Acquah
- Emmanuel Akatibo
- Emmanuel Barrios
- Emmy Runigamugabo
- Enas Alaloul
- Enas Alqahtani
- Enoch Dagoe
- Enoch Tackie
- Eriberto Farinella
- Eric Ackom
- Eric Kofi Appiah
- Erick Samuel Florez Farfan
- Erik Hervieux
- Erik Schadde
- Erika Vicario
- Erikas Laugzemys
- Ernest Yemalin Stephane Ahounou
- Eslam Elbanby
- Eslam Ezzat
- Esraa Abd Elkhalek
- Esraa Abdalmageed Kasem
- Esraa Alm Eldeen
- Esraa El-Gizawy
- Esraa El-Taher
- Esraa Elhalawany
- Esraa Gamal
- Esraa Ghanem
- Esraa Kasem
- Esraa Samir Elbanby
- Esraay Zakaria
- Ethar Hany
- Etienne Courboin
- Eu Xian Lee
- Euan Macdonald
- Eugene Niyirera
- Eugenio Grasset
- Eugenio Morandi
- Eugenio Panieri
- Eva Borin
- Evangelos Voulgaris
- Evelina Slapelyte
- Evelina Woin
- Ewan Macdermid
- Ewen M Harrison
- Eyad Khalifah
- Ezio Veronese
- Fabian Deichsel
- Fabrizio Aquilino
- Fahd Abdel Sabour
- Faisal Idris
- Faith Qi Hui Leong
- Fanjandrainy Rasoaherinomenjanahary
- Farah Mahmoud Ali
- Farhana Iftekhar
- Farrag Sayed
- Fatai Balogun
- Fatema Al Bastawis
- Fatema Asi
- Fathee Nada
- Fathi Elzowawi
- Fathia Abd El-Salam
- Fathy Sroor
- Fatima Baluch
- Fatimah I Elgendy
- Fatma Elkady
- Faustin Ntirenganya
- Fawzia Abdellatif Elsherif
- Fawzy Mohamed
- Fayez Elian Al Barrawi
- Fazlin Noor
- Federica Bianco
- Federica Falaschi
- Federico Coccolini
- Fei Zheng
- Felipe Zapata
- Felix Alakaloko
- Felix Lee
- Feng Yih Chai
- Ferdy Iskandar
- Fernanda Altoe
- Fernanda Frade
- Fernande Djivoh
- Fernando Espinoza
- Fernando Fernandez-Bueno
- Fernando Tale
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- Theodosios Theodosopoulos
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- Thomas M Drake
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- Thomas Sherman
- Thomas Tetens Moe
- Thuraya Alzayat
- Thusitha Sampath Hettiarachchi
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- Tina Gaarder
- Tobias Schuetz
- Todisoa Emmanuella Christina Tolotra
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- Toqa Khafagy
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- Tuan Nur'Azmah Tuan Mat
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- Tzu-Ling Chen
- Uday Muddebihal
- Ufuk Karabacak
- Ulf Gunnarsson
- Ulf Gustafsson
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- Umme Salma
- Usama Hantour
- Uthman Alamoudi
- Valdemaras Jotautas
- Valentine Parent
- Vanessa Dina Palomino Castillo
- Vanessa Msosa
- Vania Guglielmo
- Vania Silvestri
- Vasileios Despotidis
- Vasileios Kalles
- Vasiliki Soulou
- Vassilis Kalles
- Veereanna Shatkar
- Venerand Barendegere
- Veronica Grassi
- Veronica Lazzari
- Vicky Jennings
- Victor Dassah
- Victor Etwire
- Victor Kong
- Victor Manuel Quintero Riaza
- Victor Nwinee
- Victoria K Proctor
- Vijaid Upadhyaya
- Vijay Gadhvi
- Viktorija Ambrozeviciute
- Viktorija Nevieraite
- Ville Sallinen
- Vimalakanthan Thanusan
- Vincas Jonas Banaitis
- Virgilijus Beisa
- Viviana Sollazzo
- Vivien Graffieille
- Vizir Jean Paul Nsengimana
- Vladimir Khokha
- Vollmer Sebastian
- Vu Thanh Hien Le
- Vytautas Gaižauskas
- Vytautas Lipnickas
- Wahid Anwer
- Wai Cheong Soon
- Wai Him Lam
- Wairimu Ndegwa
- Waleed Thabet
- Walid Adham
- Walter Forno
- Walter Ruiz Panez
- Wan Nurul 'Ain Wan Mohd Nasir
- Wanigasekara Senanayake Mudiyanselage Kithsiri Janakantha Senanayake
- Ward Hamsho
- Wasim Dar
- Wedyan Alhazmi
- Wei Guo
- Weiguang Ho
- Weihei Dao
- Wendy Leslie Messa Aguilar
- Wennweoi Goh
- Wifanto Saditya Jeo
- Wilfredo Pino
- William Appeadu-Mensah
- William Beasley
- William Bonney
- William Hutch
- William J Lossius
- William Milligan
- Willy Alcca Ticona
- Wing Sum Li
- Witold Chachulski
- Xavier Delforge
- Xianelle Rodriguez
- Xinwei Low
- Xue Wei Chan
- Ya Theng Neo
- Yacoubou Imorou Souaibou
- Yahaya Ukwenya
- Yahya Salama
- Yaseen Rajjoub
- Yasmein Ibrahim
- Yasmin Abd-Elrasoul
- Yasmin Elfouly
- Yasmin Hegazy
- Yasmin Soliman
- Yasser Abd El Salam
- Yee Wen Tan
- Yehia Zakaria
- Yella Reddy
- Yi Koon Tan
- Yi Ting Mok
- Yih Jeng Cheong
- Yiing Yee Gan
- Yishan Der
- Yogendra Praveen Mogan
- Yomna Allam
- Yomna Hosny Asar
- Yong Yong Tew
- Yousef Abuowda
- Yousra El Shoura
- Ysabel Esthefany Alejos Bermúdez
- Yuk Hong Eric Cheung
- Yuksel Altinel
- Yung Kok Ng
- Yuri Macchitella
- Yves Aigrain
- Yücel Cengiz
- Zaher Mikwar
- Zahra Jaffry
- Zain Ali Khan
- Zainab Iftikhar
- Zaynab M Elsayed
- Zhongtao Zhang
- Zi Hao Sam
- Zigmantas Urniežius
- Zilvinas Dambrauskas
- Zineb Bentounsi
- Zygimantas Tverskis
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2022
- Field of study
Background There is a substantial gap in provision of adequate surgical care in many low- and middle-income countries. This study aimed to identify the economic burden of unmet surgical need for the common condition of appendicitis. Methods Data on the incidence of appendicitis from 170 countries and two different approaches were used to estimate numbers of patients who do not receive surgery: as a fixed proportion of the total unmet surgical need per country (approach 1); and based on country income status (approach 2). Indirect costs with current levels of access and local quality, and those if quality were at the standards of high-income countries, were estimated. A human capital approach was applied, focusing on the economic burden resulting from premature death and absenteeism. Results Excess mortality was 4185 per 100 000 cases of appendicitis using approach 1 and 3448 per 100 000 using approach 2. The economic burden of continuing current levels of access and local quality was US 92492millionusingapproach1and73 141 million using approach 2. The economic burden of not providing surgical care to the standards of high-income countries was 95004millionusingapproach1and75 666 million using approach 2. The largest share of these costs resulted from premature death (97.7 per cent) and lack of access (97.0 per cent) in contrast to lack of quality. Conclusion For a comparatively non-complex emergency condition such as appendicitis, increasing access to care should be prioritized. Although improving quality of care should not be neglected, increasing provision of care at current standards could reduce societal costs substantially