Quality of work life and job satisfaction among early-career pharmacists in Africa’s most populous country: A nationwide survey in Nigeria

This study examined the factors affecting the quality of work life and job satisfaction among early-career pharmacists in Nigeria. This was a cross-sectional survey conducted across the six geopolitical zones in Nigeria. We used the database of licensed pharmacists in each selected state to identify eligible participants. Information sheets were sent to all potential participants through email. If interested, they signed the consent form and were sent the survey online to be completed and returned within 24 h. Validated questionnaires were used to evaluate their quality of work life and job satisfaction. Descriptive statistics (frequency, mean, and standard deviation) were used to summarize the data. Of a total of 373 participants; 323 (86.6%) were single, and 245 (65.7%) were working in government-owned hospitals. The findings showed that the quality of work life information affects the job satisfaction of early-career pharmacists. Reasons reported for poor job satisfaction were poor remuneration, increased workload, a lack of employer support, and an unconducive work environment. Suggestions for possible interventions included an increase in remuneration, an accommodating work atmosphere, and flexible working hours. Our findings show a direct relationship between quality of work life and job satisfaction; predictors of job satisfaction were salary, employer assistance, health insurance, and length of leave

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field

33-36Perceived Psychosocial Determinants of Female Criminality in South East Nigeria

Abstract The study investigated perceived psychosocial determinants of female criminality. 150 respondents comprising 82 females and 68 males selected from the three (3) Metropolitan Local Governments in Enugu State were used as sample. The participants were within the age bracket of 25-55 years with a mean age of 35 years. A 15 item questionnaire designed to measure perceived psychosocial determinants of female criminality was used for data collection. Survey research design was adopted while Chi-square statistics was used for data analysis. Findings revealed that broken home was perceived as a determinant of female criminality X2= 126.84 P<.001. A significant outcome was also observed on poor parental monitoring as a perceived determinant of female criminality X2= 161.6 P<.001. Findings were discussed in relation with the literature reviewed and recommendations were also made

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

International audienceIn 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field