Teleneurology in the COVID-19 era

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Caracterización física y química de ríos de montaña (Tafí del Valle-Tucumán-Argentina)

En este trabajo se estudió durante el ciclo anual 2000-2001, a los ríos Blanquito, Churqui, de La Ovejería, de Las Carreras, Tafí, El Mollar y Los Sosa, ubicados a 2000 msnm en el valle de Tafí (Tucumán-Argentina). El objetivo de esta contribución fue caracterizar e interpretar las variaciones espacio-temporales de los parámetros físicos y químicos en relación con la dinámica hidrológica a la que se encuentran sujetos estos ecosistemas acuáticos y además, comparar la calidad de sus aguas. Las variables físicas y químicas analizadas fueron: oxígeno disuelto (OD), demanda bioquímica de oxígeno (DBO5), iones mayoritarios, compuestos nitrogenados, ortofosfatos y metales pesados. Los resultados muestran que la temperatura varió entre 4.2 y 28 ◦C, el pH fluctuó de neutro a alcalino (6.7-8.7) y la conductividad eléctrica entre 64 y 296 μS/cm. El OD y la DBO5 se mostraron estables, alcanzando máximos valores de 10.1 y 2 mg/l, respectivamente. El agua pudo caracterizarse como bicarbonatada-cálcica dominante. Las concentraciones de N-NO−3 oscilaron entre 0.1 y 0.6 mg/l, el N-NO−2 sólo llegó en el río Churqui a 0.01 mg/l y el N-NH+4 alcanzó valores de 0.8 mg/l. En general los registros de los ortofosfatos fueron inferiores a 0.2 mg/l. Los metales pesados Cu2+ y Fe3+ llegaron a un máximo de 3 mg/l y 1.8 mg/l, respectivamente. Las mayores concentraciones del hierro se presentaron en el río de La Ovejería y de cobre en el río El Mollar, probablemente por contaminación antropogénica. La interpretación de los análisis de componentes principales realizados sobre la matriz de parámetros físicos y químicos, permitió diferenciar a los sistemas lóticos temporal y espacialmente. El componente 1 ordenó a los ríos de acuerdo a los iones mayoritarios predominantes y a la conductividad, lo que podría interpretarse como un eje de mineralización. Los componentes 2 y 3, ordenaron las muestras de invierno y primavera y las de verano y otoño, de acuerdo a la variación cíclica estacional coincidiendo con las condiciones climáticas del área de estudio.In this work, throughout the 2000-2001 annual period, the Blanquito, Churqui, de La Ovejería, de Las Carreras, Tafí, El Mollar and Los Sosa rivers, located at 2000 m above sea level in the Taf'ı Valley (Tucumán-Argentina) were studied. The aim of this paper was not only to characterize and understand the spatial and temporal variations of physical and chemical parameters related to the hydrological dynamics these aquatic ecosystems are subject to, but also to compare the quality of their waters. Physical and chemical variables analysed were: dissolved oxygen (DO), biochemical oxygen demand (BOD5), preponderant ions, nitrogenous compounds, orthophosphates, and heavy metals. Results show that the temperature ranged between 4.2 and 28 ◦C, pH fluctuated from neutral to alkaline (6.7-8.7) and electrical conductivity varied between 64 and 296 μS/cm. DO and BOD5 were stable and reached maximum values of 10.1 and 2 mg/l, respectively. The water could be characterized as mainly bicarbonated-calcic. N-NO−3 concentrations ranged between 0.1 and 0.6 mg/l, N-NO−2 reaching only 0.01 mg/l in the Churqui river, and N-NH+4 reached values of 0.8 mg/l. In general, orthophosphate records were lower than 0.2 mg/l. Maximum values for heavy metals, Cu2 + and Fe3 + were 3 mg/l y 1.8 mg/l, respectively. Iron highest concentrations were found in de La Ovejería river, whereas those for copper were found in El Mollar river, probably due to anthropogenic pollution. The interpretation of the main component analyses carried out on the physical and chemical parameters matrix, allowed to differentiate lotic systems both temporally and spatially. Component 1 ordered the rivers according to both the prevailing ions and conductivity, which could be interpreted as a mineralization axis. Components 2 and 3 ordered the winter and spring, and the summer and autumn samples according to the seasonal cyclic variation, coinciding with the climatic conditions of the area under study

Multi-scale and cross-dimensional TMS mapping: A proof of principle in patients with Parkinson’s disease and deep brain stimulation

IntroductionTranscranial magnetic stimulation (TMS) mapping has become a critical tool for exploratory studies of the human corticomotor (M1) organization. Here, we propose to gather existing cutting-edge TMS-EMG and TMS-EEG approaches into a combined multi-dimensional TMS mapping that considers local and whole-brain excitability changes as well as state and time-specific changes in cortical activity. We applied this multi-dimensional TMS mapping approach to patients with Parkinson’s disease (PD) with Deep brain stimulation (DBS) of the sub-thalamic nucleus (STN) ON and OFF. Our goal was to identifying one or several TMS mapping-derived markers that could provide unprecedent new insights onto the mechanisms of DBS in movement disorders.MethodsSix PD patients (1 female, mean age: 62.5 yo [59–65]) implanted with DBS-STN for 1 year, underwent a robotized sulcus-shaped TMS motor mapping to measure changes in muscle-specific corticomotor representations and a movement initiation task to probe state-dependent modulations of corticospinal excitability in the ON (using clinically relevant DBS parameters) and OFF DBS states. Cortical excitability and evoked dynamics of three cortical areas involved in the neural control of voluntary movements (M1, pre-supplementary motor area – preSMA and inferior frontal gyrus – IFG) were then mapped using TMS-EEG coupling in the ON and OFF state. Lastly, we investigated the timing and nature of the STN-to-M1 inputs using a paired pulse DBS-TMS-EEG protocol.ResultsIn our sample of patients, DBS appeared to induce fast within-area somatotopic re-arrangements of motor finger representations in M1, as revealed by mediolateral shifts of corticomuscle representations. STN-DBS improved reaction times while up-regulating corticospinal excitability, especially during endogenous motor preparation. Evoked dynamics revealed marked increases in inhibitory circuits in the IFG and M1 with DBS ON. Finally, inhibitory conditioning effects of STN single pulses on corticomotor activity were found at timings relevant for the activation of inhibitory GABAergic receptors (4 and 20 ms).ConclusionTaken together, these results suggest a predominant role of some markers in explaining beneficial DBS effects, such as a context-dependent modulation of corticospinal excitability and the recruitment of distinct inhibitory circuits, involving long-range projections from higher level motor centers and local GABAergic neuronal populations. These combined measures might help to identify discriminative features of DBS mechanisms towards deep clinical phenotyping of DBS effects in Parkinson’s Disease and in other pathological conditions

Standalone vertex finding in the ATLAS muon spectrometer

A dedicated reconstruction algorithm to find decay vertices in the ATLAS muon spectrometer is presented. The algorithm searches the region just upstream of or inside the muon spectrometer volume for multi-particle vertices that originate from the decay of particles with long decay paths. The performance of the algorithm is evaluated using both a sample of simulated Higgs boson events, in which the Higgs boson decays to long-lived neutral particles that in turn decay to bbar b final states, and pp collision data at √s = 7 TeV collected with the ATLAS detector at the LHC during 2011

Measurements of Higgs boson production and couplings in diboson final states with the ATLAS detector at the LHC

Measurements are presented of production properties and couplings of the recently discovered Higgs boson using the decays into boson pairs, H →γ γ, H → Z Z∗ →4l and H →W W∗ →lνlν. The results are based on the complete pp collision data sample recorded by the ATLAS experiment at the CERN Large Hadron Collider at centre-of-mass energies of √s = 7 TeV and √s = 8 TeV, corresponding to an integrated luminosity of about 25 fb−1. Evidence for Higgs boson production through vector-boson fusion is reported. Results of combined fits probing Higgs boson couplings to fermions and bosons, as well as anomalous contributions to loop-induced production and decay modes, are presented. All measurements are consistent with expectations for the Standard Model Higgs boson

Measurement of the top quark-pair production cross section with ATLAS in pp collisions at \sqrt{s}=7\TeV

A measurement of the production cross-section for top quark pairs(\ttbar) in $pp$ collisions at \sqrt{s}=7 \TeV is presented using data recorded with the ATLAS detector at the Large Hadron Collider. Events are selected in two different topologies: single lepton (electron $e$ or muon $\mu$) with large missing transverse energy and at least four jets, and dilepton ($ee$, $\mu\mu$ or $e\mu$) with large missing transverse energy and at least two jets. In a data sample of 2.9 pb-1, 37 candidate events are observed in the single-lepton topology and 9 events in the dilepton topology. The corresponding expected backgrounds from non-\ttbar Standard Model processes are estimated using data-driven methods and determined to be $12.2 \pm 3.9$ events and $2.5 \pm 0.6$ events, respectively. The kinematic properties of the selected events are consistent with SM \ttbar production. The inclusive top quark pair production cross-section is measured to be \sigmattbar=145 \pm 31 ^{+42}_{-27} pb where the first uncertainty is statistical and the second systematic. The measurement agrees with perturbative QCD calculations.Comment: 30 pages plus author list (50 pages total), 9 figures, 11 tables, CERN-PH number and final journal adde

Measurement of the top quark pair cross section with ATLAS in pp collisions at √s=7 TeV using final states with an electron or a muon and a hadronically decaying τ lepton

A measurement of the cross section of top quark pair production in proton-proton collisions recorded with the ATLAS detector at the Large Hadron Collider at a centre-of-mass energy of 7 TeV is reported. The data sample used corresponds to an integrated luminosity of 2.05 fb -1. Events with an isolated electron or muon and a τ lepton decaying hadronically are used. In addition, a large missing transverse momentum and two or more energetic jets are required. At least one of the jets must be identified as originating from a b quark. The measured cross section, σtt-=186±13(stat.)±20(syst.)±7(lumi.) pb, is in good agreement with the Standard Model prediction

Hunt for new phenomena using large jet multiplicities and missing transverse momentum with ATLAS in 4.7 fb−1 of √s=7 TeV proton-proton collisions

Results are presented of a search for new particles decaying to large numbers of jets in association with missing transverse momentum, using 4.7 fb−1 of pp collision data at s√=7TeV collected by the ATLAS experiment at the Large Hadron Collider in 2011. The event selection requires missing transverse momentum, no isolated electrons or muons, and from ≥6 to ≥9 jets. No evidence is found for physics beyond the Standard Model. The results are interpreted in the context of a MSUGRA/CMSSM supersymmetric model, where, for large universal scalar mass m 0, gluino masses smaller than 840 GeV are excluded at the 95% confidence level, extending previously published limits. Within a simplified model containing only a gluino octet and a neutralino, gluino masses smaller than 870 GeV are similarly excluded for neutralino masses below 100 GeV

Metabolite and lipoprotein profiles reveal sex-related oxidative stress imbalance in de novo drug-naive Parkinson's disease patients

Parkinson's disease (PD) is the neurological disorder showing the greatest rise in prevalence from 1990 to 2016. Despite clinical definition criteria and a tremendous effort to develop objective biomarkers, precise diagnosis of PD is still unavailable at early stage. In recent years, an increasing number of studies have used omic methods to unveil the molecular basis of PD, providing a detailed characterization of potentially pathological alterations in various biological specimens. Metabolomics could provide useful insights to deepen our knowledge of PD aetiopathogenesis, to identify signatures that distinguish groups of patients and uncover responsive biomarkers of PD that may be significant in early detection and in tracking the disease progression and drug treatment efficacy. The present work is the first large metabolomic study based on nuclear magnetic resonance (NMR) with an independent validation cohort aiming at the serum characterization of de novo drug-naive PD patients. Here, NMR is applied to sera from large training and independent validation cohorts of German subjects. Multivariate and univariate approaches are used to infer metabolic differences that characterize the metabolite and the lipoprotein profiles of newly diagnosed de novo drug-naive PD patients also in relation to the biological sex of the subjects in the study, evidencing a more pronounced fingerprint of the pathology in male patients. The presence of a validation cohort allowed us to confirm altered levels of acetone and cholesterol in male PD patients. By comparing the metabolites and lipoproteins levels among de novo drug-naive PD patients, age- and sex-matched healthy controls, and a group of advanced PD patients, we detected several descriptors of stronger oxidative stress

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements