On the relationship between ENSO and overland accumulated cyclone energy of landfalling tropical cyclones over the western North Pacific

This study investigates the relationship between El Niño-Southern Oscillation (ENSO) and overland accumulated cyclone energy (ACE) of tropical cyclones (TCs) over the western North Pacific (WNP). We find that there is only a weak correlation between ENSO and overland ACE during 1979–2019, compared to the significant relationship between ENSO and basinwide ACE over the WNP as reported in previous publications. Overland ACE is generally smaller in El Niño and La Niña years than that in neutral years, which mainly results from lower landfall frequency and shorter duration after landfall. Relative to neutral years, overland ACE is lower over almost the entire China mainland in both El Niño and La Niña years, which can be related to the changes in the formation and movement of landfalling TCs. During El Niño and La Niña years, fewer landfalling TCs form over the western WNP, mainly resulting from reduced 850-hPa humidity, which leads to a less chance of TCs making landfall over China mainland. In addition, the eastward (westward) shift of the western Pacific subtropical high in El Niño (La Niña) years steers more TCs to make landfall over the southern (northern) China

Serum Sodium Concentration in Patients with Portal Hypertension and Acute Gastrointestinal Bleeding Treated with Terlipressin: A Retrospective Observational Study

This retrospective observational study aimed to investigate the risk of serum sodium concentration in patients treated with terlipressin and attempted to explore the factors associated with serum sodium concentration. We included 17 patients with portal hypertension treated with terlipressin (Group 1), 7 with portal hypertension treated with somatostatin/octreotide (Group 2), 20 with acute non-variceal gastrointestinal bleeding treated with somatostatin/octreotide (Group 3), and 19 with acute pancreatitis treated with somatostatin/octreotide (Group 4). In all groups, serum sodium concentration at baseline was not significantly different from the lowest value during the infusion of terlipressin, somatostatin, or octreotide (Group 1: 136.95 ± 4.68 versus 135.52 ± 4.79, p = 0.426; Group 2: 139.64 ± 3.86 versus 138.41 ± 5.34, p = 0.813; Group 3: 138.02 ± 4.08 versus 137.69 ± 3.11, p = 0.630; Group 4: 135.96 ± 6.87 versus 134.60 ± 3.40, p = 0.098). The rate of serum sodium concentration reduction in Group 1 (8/17) was not significantly different from Group 2 (3/7, p = 1.000), Group 3 (11/20, p = 0.746), or Group 4 (14/19, p = 0.171). Age, sex, baseline MELD and Child-Pugh scores, cDDD value and duration of terlipressin, blood transfusion, and diuretics and paracentesis during terlipressin were not significantly associated with serum sodium concentration reduction in Group 1. In conclusion, serum sodium concentration is often reduced in patients treated with terlipressin. However, the association of sodium concentration reduction with terlipressin should be clarified

Challenges of EGFR-TKIs in NSCLC and the potential role of herbs and active compounds: From mechanism to clinical practice

Epidermal growth factor receptor (EGFR) mutations are the most common oncogenic driver in non-small cell lung cancer (NSCLC). Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are widely used in the treatment of lung cancer, especially in the first-line treatment of advanced NSCLC, and EGFR-TKIs monotherapy has achieved better efficacy and tolerability compared with standard chemotherapy. However, acquired resistance to EGFR-TKIs and associated adverse events pose a significant obstacle to targeted lung cancer therapy. Therefore, there is an urgent need to seek effective interventions to overcome these limitations. Natural medicines have shown potential therapeutic advantages in reversing acquired resistance to EGFR-TKIs and reducing adverse events, bringing new options and directions for EGFR-TKIs combination therapy. In this paper, we systematically demonstrated the resistance mechanism of EGFR-TKIs, the clinical strategy of each generation of EGFR-TKIs in the synergistic treatment of NSCLC, the treatment-related adverse events of EGFR-TKIs, and the potential role of traditional Chinese medicine in overcoming the resistance and adverse reactions of EGFR-TKIs. Herbs and active compounds have the potential to act synergistically through multiple pathways and multiple mechanisms of overall regulation, combined with targeted therapy, and are expected to be an innovative model for NSCLC treatment

最低工資有幾低? 貧窮新一代的就業困境報告

為了解香港青年對就業、貧窮、體面生活、相關政策的看法，以及他們收入和支出的情況，嶺南大學政策研究院、文化研究及發展中心聯合進行一項題為《最低工資有幾低？貧窮新一代的就業困境報告》的調查。結果發現，四成接受深度訪談的青年自認貧窮，而絕大部分已有全職工作的受訪青年認為，最低工資調整幅度太低，自己未能受惠。 嶺大研究團隊從2022年5月至12月，先後透過兩輪深度訪談，訪問了67位18至29歲、收入低於2萬元、有工作經驗的青年。另外，團隊亦透過兩輪問卷調查，分別收集到164份及253份有效回覆。 調查結果發現，絕大部分年輕人覺得自己的工資太低，待遇與工作不相稱。受訪青年的收入來源包括全職工作、兼職工作。深度訪談年輕人的收入中位數為15,200元，而問卷調查的收入中位數結果則是6,000至9,999元。一方面，大部分有全職工作的青年認為自己工時長、部分行業長期低薪，比不上任職其他行業的同輩，而覺得不滿。壓力同時來自高昂的生活成本和遙不可及的人生目標，包括置業。 大約四成接受第二輪深度訪談的青年自認是貧窮，他們對於貧窮有多元化的理解。有青年認為三餐不繼才算得上貧窮，有些人覺得人工未達到港人月入中位數就算是貧窮，亦有人認很多目標未能達成，導致「精神貧窮」。其餘自覺不貧窮的青年部分歸因於家庭支援，可以滿足基本需求以外的消費，例如購物和旅遊。 絕大部分已有全職工作的受訪青年覺得最低工資調整幅度太低，自己未能受惠。無論認為自己屬於中產或基層的受訪者，均有共識，認為即使法定最低工資水平提升至40元依然是太低，與市場脫節，調整幅度不合理。不少人往往將最低工資時薪和「一餐飯」的開支掛鉤，認為最低工資水平要吃得起「一餐飯」才合理。受訪者認為最低工資如有合理升幅及政策檢討，對基層家庭及兼職工作者有很大幫助。 問卷調查結果推算，受訪青年要滿足現時的生活開支水平，時薪應該要達到71.6元。問卷調查的結果顯示青年的個人月均生活支出為16,789元，扣除教育開支，平均每月支出約14,894元，按一個月工作26日，每日8小時計算出時薪水平為71.6元，與目前最低工資水平相距很遠。 研究團隊建議，政府應從多方面著手解決此迫切的社會問題。首先，當局應檢討最低工資政策的定位，使它與其他扶貧政策互相配合，以保障不同需要的群體；第二，當局應透明化最低工資的調整過程，改為「一年一檢」；第三，團隊建議重啟標準工時立法程序，訂明標準工時應為每周40小時，加班工資應為正常工資的1.5倍，每月亦應設有加班和總工時上限，並以此為基礎制定「過勞死」的法律定義，把過勞死定為僱主須按《僱員補償條例》（第282章）作出補償的事故。最後，團隊建議政府主動開展設立失業保障制度的工作，包括探討供款式失業保險、檢討現行失業綜援、遣散費／長期服務金，並重視年輕人對相關政策的意見。https://commons.ln.edu.hk/ccrd_report/1003/thumbnail.jp

A sheep pangenome reveals the spectrum of structural variations and their effects on tail phenotypes

Structural variations (SVs) are a major contributor to genetic diversity and phenotypic variations, but their prevalence and functions in domestic animals are largely unexplored. Here we generated high-quality genome assemblies for 15 individuals from genetically diverse sheep breeds using Pacific Biosciences (PacBio) high-fidelity sequencing, discovering 130.3 Mb nonreference sequences, from which 588 genes were annotated. A total of 149,158 biallelic insertions/deletions, 6531 divergent alleles, and 14,707 multiallelic variations with precise breakpoints were discovered. The SV spectrum is characterized by an excess of derived insertions compared to deletions (94,422 vs. 33,571), suggesting recent active LINE expansions in sheep. Nearly half of the SVs display low to moderate linkage disequilibrium with surrounding single-nucleotide polymorphisms (SNPs) and most SVs cannot be tagged by SNP probes from the widely used ovine 50K SNP chip. We identified 865 population-stratified SVs including 122 SVs possibly derived in the domestication process among 690 individuals from sheep breeds worldwide. A novel 168-bp insertion in the 5' untranslated region (5' UTR) of HOXB13 is found at high frequency in long-tailed sheep. Further genome-wide association study and gene expression analyses suggest that this mutation is causative for the long-tail trait. In summary, we have developed a panel of high-quality de novo assemblies and present a catalog of structural variations in sheep. Our data capture abundant candidate functional variations that were previously unexplored and provide a fundamental resource for understanding trait biology in sheep

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

Memristive Characteristics of the Single-Layer P-Type CuAlO₂ and N-Type ZnO Memristors

Memristive behaviors are demonstrated in the single-layer oxide-based devices. The conduction states can be continually modulated with different pulses or voltage sweeps. Here, the p-CuAlO2- and n-ZnO-based memristors show the opposite bias polarity dependence with the help of tip electrode. It is well known that the conductivity of p-type and n-type semiconductor materials has the opposite oxygen concentration dependence. Thus, the memristive behaviors may attribute to the oxygen ion migration in the dielectric layers for the single-layer oxide based memristors. Further, based on the redox, the model of compressing dielectric layer thickness has been proposed to explain the memristive behavior

pH-Regulated Heterostructure Porous Particles Enable Similarly Sized Protein Separation

Porous particles are frequently used for various healthcare applications that involve protein separation processes. However, conventional porous particles, either homogeneous particles or those subjected to surface modification with a layer of specific molecules, often encounter bottlenecks in separating proteins with similar size. Here, it is reported that heterostructure-enabled separation particles (HESP), synthesized by a double emulsion interfacial polymerization process, can effectively and rapidly separate similarly sized proteins. Double emulsion interfacial polymerization endows the HESP with a nanoscale carboxylic layer outside the particles and inside the pores, allowing pH-regulated selective adsorption of proteins. Thus, by optimizing the environmental pH, proteins with similar size can be effectively and rapidly separated. These HESP are expected to show potential in widespread applications ranging from biomolecule adsorption, encapsulation, and separation to controlled release and other biomedical fields

Life on Magnet: Long-Term Exposure of Moderate Static Magnetic Fields on the Lifespan and Healthspan of Mice

All living organisms on the Earth live and evolve in the presence of the weak geomagnetic field, a quasi-uniform static magnetic field (SMF). In the meantime, although the effects of moderate and high SMFs have been investigated on multiple aspects of a living organism, a long-term SMF exposure of more than 1 year has never been reported. Here, we investigated the influence of a moderate SMF (70–220 mT head-to-toe) long-term continuous exposure (1.7 years) to two different SMF directions on healthy male C57BL/6 mice. We found that not only was the lifespan of the mice prolonged, but their healthspan was also improved. The elevated plus maze test and open field test show that SMFs could significantly improve the exploratory and locomotive activities of the aged mice. The Morris water maze test shows that SMFs could improve their spatial learning ability and spatial memory. Tissue examinations reveal that SMFs have an ameliorative effect on oxidative stress in the brain of aged mice, which was reinforced by the cellular assays, showing that SMFs could protect the PC12 cells from D-gal-induced senescence by increasing superoxide dismutase, catalase, and reducing the malonaldehyde levels. Therefore, our data show that the 1.7-year SMF exposure can improve both the lifespan and healthspan of naturally aged mice due to reduced oxidative stress, which indicates that SMFs have the potential to be used as an adjuvant physical therapy to reduce the ageing-induced health risks to benefit animals, and even humans