Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

Efeito da endogamia sobre a sobrevivência e a longevidade no escargot da espécie Helix aspersa Effect of inbreeding on viability and longevity of edible snail Helix aspersa

Estudou-se o efeito da endogamia sobre as características sobrevivência (intervalos de 0-30; 30-60; 60-90 e 90-120 dias) e longevidade do escargot da espécie Helix aspersa em três gerações consecutivas de acasalamentos entre irmãos perfeitos. Os animais foram criados em laboratório com temperatura entre 20 e 25ºC e umidade relativa entre 70 a 90%. O menor percentual de sobrevivência ocorreu no primeiro intervalo, mas, com o aumento da endogamia, observou-se diminuição na sobrevivência nos quatro intervalos testados. A longevidade média foi de 314 e 306 dias para as gerações um e três, respectivamente, não tendo sido observados animais em hibernação. O estudo de simulação para o caráter sobrevivência, em função do coeficiente de endogamia, indicou que se deve iniciar uma criação com, pelo menos, 100 reprodutores não aparentados.The effect of inbreeding on longevity and viability (intervals of 0-30, 30-60, 60-90, and 90-120 days of birth) in three consecutive generations of full sibs of escargot Helix aspersa raised under laboratory conditions (20-25ºC temperature; 70-90% relative humidity) was studied. Inbreeding effects decreased the viability for all the studied intervals. The longevity means were 314 and 306 days, respectively to the first and third generations. Hibernating animals were not observed. Population size of at least 100 non-related mating escargots replaced after 10 generations to avoid inbreeding effect is recommended

Classification Of Haematopoietic And Lymphoid Tumors. Who, Standardization Of Nomenclature In Portuguese, 4 Th Edition [classificação Dos Tumores Hematopoéticos E Linfoides De Acordo Com A Oms: Padronização Da Nomenclatura Em Língua Portuguesa, 4 A Edição]

Introduction: The World Health Organization (WHO) classification of hematopoietic and lymphoid tissue (4 th edition, 2008) tumors constitutes an updated review of the 3 rd edition published in 2001. The translation of the nomenclature used to describe the entities should be clear, precise and uniform so that clinicians, pathologists and researchers involved in the onco-hematopathological area may identify them accurately. Objective: With this purpose, the authors present an updated proposal and a terminological standardization in Portuguese based on WHO/2008.476643648Harris, N.L., Jaffe, E.S., Stein, H., Banks, P.M., Chan, J.K.C., Cleary, M.L., Delsol, G., Warnke, R.A., A revised European-American classification of lymphoid neoplasms: A proposal from the International Lymphoma Study Group (1994) Blood, 84 (5), pp. 1361-1392Jaffe, E.S., (2001) Tumors of Haematopoietic and Lymphoid Tissues, , Lyon: IARC PressPaes, R.A.P., (2002) Classificação da Organização Mundial da Saúde para as Neoplasias dos Tecidos Hematopoético e Linfoide: Proposta de Padronização Terminológica em Língua Portuguesa do Grupo de Hematopatologia da Sociedade Brasileira de Patologia, 38, pp. 237-239. , Rio de JaneiroSwerdlow, S.H., (2008) World Health Organization Classification of Tumors of Haematopoietic and Lymphoid Tissues, , Lyon: IAR