Conserving California Condors in the 1980s

By the late 1970s, the California condor (Gymnogyps californianus) was in serious trouble, with probably no more than about 30 birds left in existence, all in a mountainous region just north of Los Angeles that is vegetated mainly in chaparral and grasslands. All estimates of population size and trends offered since the early condor studies by Carl Koford in the 1930s and 1940s indicated a continuing decline toward extinction, and it appeared that few years were left before the species would be gone (see Koford, 1953; Wilbur, 1978). Evidently, the conservation steps that had been taken, including the creation of a number of important condor reserves, were not resulting in recovery of the species

Conserving California Condors in the 1980s

By the late 1970s, the California condor (Gymnogyps californianus) was in serious trouble, with probably no more than about 30 birds left in existence, all in a mountainous region just north of Los Angeles that is vegetated mainly in chaparral and grasslands. All estimates of population size and trends offered since the early condor studies by Carl Koford in the 1930s and 1940s indicated a continuing decline toward extinction, and it appeared that few years were left before the species would be gone (see Koford, 1953; Wilbur, 1978). Evidently, the conservation steps that had been taken, including the creation of a number of important condor reserves, were not resulting in recovery of the species

Discerning Aggregation in Homogeneous Ensembles: A General Description of Photon Counting Spectroscopy in Diffusing Systems

In order to discern aggregation in solutions, we present a quantum mechanical analog of the photon statistics from fluorescent molecules diffusing through a focused beam. A generating functional is developed to fully describe the experimental physical system as well as the statistics. Histograms of the measured time delay between photon counts are fit by an analytical solution describing the static as well as diffusing regimes. To determine empirical fitting parameters, fluorescence correlation spectroscopy is used in parallel to the photon counting. For expedient analysis, we find that the distribution's deviation from a single Poisson shows a difference between two single fluor moments or a double fluor aggregate of the same total intensities. Initial studies were performed on fixed-state aggregates limited to dimerization. However preliminary results on reactive species suggest that the method can be used to characterize any aggregating system.Comment: 30 pages, 5 figure

Introgression in the genus Campylobacter: generation and spread of mosaic alleles

Horizontal genetic exchange strongly influences the evolution of many bacteria, substantially contributing to difficulties in defining their position in taxonomic groups. In particular, how clusters of related bacterial genotypes – currently classified as microbiological species – evolve and are maintained remains controversial. The nature and magnitude of gene exchange between two closely related (approx. 15 % nucleotide divergence) microbiologically defined species, Campylobacter jejuni and Campylobacter coli, was investigated by the examination of mosaic alleles, those with some ancestry from each population. A total of 1738 alleles from 2953 seven-locus housekeeping gene sequence types (STs) were probabilistically assigned to each species group with the model-based clustering algorithm structure. Alleles with less than 75 % assignment probability to one of the populations were confirmed as mosaics using the structure linkage model. For each of these, the putative source of the recombinant region was determined and the allele was mapped onto a clonalframe genealogy derived from concatenated ST sequences. This enabled the direction and frequency of introgression between the two populations to be established, with 8.3 % of C. coli clade 1 alleles having acquired C. jejuni sequence, compared to 0.5 % for the reciprocal process. Once generated, mosaic genes spread within C. coli clade 1 by a combination of clonal expansion and lateral gene transfer, with some evidence of erosion of the mosaics by reacquisition of C. coli sequence. These observations confirm previous analyses of the exchange of complete housekeeping alleles and extend this work by describing the processes of horizontal gene transfer and subsequent spread within recipient species

Variation in use of surveillance colonoscopy among colorectal cancer survivors in the United States

<p>Abstract</p> <p>Background</p> <p>Clinical practice guidelines recommend colonoscopies at regular intervals for colorectal cancer (CRC) survivors. Using data from a large, multi-regional, population-based cohort, we describe the rate of surveillance colonoscopy and its association with geographic, sociodemographic, clinical, and health services characteristics.</p> <p>Methods</p> <p>We studied CRC survivors enrolled in the Cancer Care Outcomes Research and Surveillance (CanCORS) study. Eligible survivors were diagnosed between 2003 and 2005, had curative surgery for CRC, and were alive without recurrences 14 months after surgery with curative intent. Data came from patient interviews and medical record abstraction. We used a multivariate logit model to identify predictors of colonoscopy use.</p> <p>Results</p> <p>Despite guidelines recommending surveillance, only 49% of the 1423 eligible survivors received a colonoscopy within 14 months after surgery. We observed large regional differences (38% to 57%) across regions. Survivors who received screening colonoscopy were more likely to: have colon cancer than rectal cancer (OR = 1.41, 95% CI: 1.05-1.90); have visited a primary care physician (OR = 1.44, 95% CI: 1.14-1.82); and received adjuvant chemotherapy (OR = 1.75, 95% CI: 1.27-2.41). Compared to survivors with no comorbidities, survivors with moderate or severe comorbidities were less likely to receive surveillance colonoscopy (OR = 0.69, 95% CI: 0.49-0.98 and OR = 0.44, 95% CI: 0.29-0.66, respectively).</p> <p>Conclusions</p> <p>Despite guidelines, more than half of CRC survivors did not receive surveillance colonoscopy within 14 months of surgery, with substantial variation by site of care. The association of primary care visits and adjuvant chemotherapy use suggests that access to care following surgery affects cancer surveillance.</p

In search of 'managerial work' : past, present and future of an analytical category

Based on a comprehensive review of literature, the paper examines how ‘managerial work’ as a fluid analytical category has been approached methodologically, theoretically, and empirically over the last 60+ years. In particular, we highlight the existence of competing scholarly understandings regarding its nature, performance, meaning, and politics. We suggest that subsequent empirical investigations have too often worked, methodologically and theoretically, to slot in, and thus effectively reduce, the term to a particular pre-existing box, rather than exploring open-endedly what and how, but also why of ‘managerial work’ as a distinct mode of situated ordering. Having represented the concept’s past and present by identifying four distinct research approaches reflected in representative publications, we suggest more attention should be devoted to a mode of analytical departure that promises to directly address suggested shortcomings in the literature. Specifically, we argue that much could be gained if contemporary notions of practice are brought into the study of managerial work. To this end, we outline the contours of a practice-based approach as a sensitizing framework for understanding managerial work, by highlighting the situated, relational, sociomaterial, meaning-making, and consequence-oriented analytical foci the approach suggests, and suggesting a number of conjoint research questions, as well as acknowledging subsequent limitations

ACVIM consensus statement: Guidelines for the identification, evaluation, and management of systemic hypertension in dogs and cats

An update to the 2007 American College of Veterinary Internal Medicine (ACVIM) consensus statement on the identification, evaluation, and management of systemic hypertension in dogs and cats was presented at the 2017 ACVIM Forum in National Harbor, MD. The updated consensus statement is presented here. The consensus statement aims to provide guidance on appropriate diagnosis and treatment of hypertension in dogs and cats

Elliptical optical solitary waves in a finite nematic liquid crystal cell

2015 Elsevier B.V. The addition of orbital angular momentum has been previously shown to stabilise beams of elliptic cross-section. In this article the evolution of such elliptical beams is explored through the use of an approximate methodology based on modulation theory. An approximate method is used as the equations that govern the optical system have no known exact solitary wave solution. This study brings to light two distinct phases in the evolution of a beam carrying orbital angular momentum. The two phases are determined by the shedding of radiation in the form of mass loss and angular momentum loss. The first phase is dominated by the shedding of angular momentum loss through spiral waves. The second phase is dominated by diffractive radiation loss which drives the elliptical solitary wave to a steady state. In addition to modulation theory, the chirp variational method is also used to study this evolution. Due to the significant role radiation loss plays in the evolution of an elliptical solitary wave, an attempt is made to couple radiation loss to the chirp variational method. This attempt furthers understanding as to why radiation loss cannot be coupled to the chirp method. The basic reason for this is that there is no consistent manner to match the chirp trial function to the generated radiating waves which is uniformly valid in time. Finally, full numerical solutions of the governing equations are compared with solutions obtained using the various variational approximations, with the best agreement achieved with modulation theory due to its ability to include both mass and angular momentum losses to shed diffractive radiation

Self-confined light waves in nematic liquid crystals

The study of light beams propagating in the nonlinear, dispersive, birefringent and nonlocal medium of nematic liquid crystals has attracted widespread interest in the last twenty years or so. We review hereby the underlying physics, theoretical modelling and numerical approximations for nonlinear beam propagation in planar cells filled with nematic liquid crystals, including bright and dark solitary waves, as well as optical vortices. The pertinent governing equations consist of a nonlinear Schrödinger-type equation for the light beam and an elliptic equation for the medium response. Since the nonlinear and coupled nature of this system presents difficulties in terms of finding exact solutions, we outline the various approaches used to resolve them, pinpointing the good agreement obtained with numerical solutions and experimental results. Measurement and material details complement the theoretical narration to underline the power of the modelling

EFSA Panel on Biological Hazards (BIOHAZ) Panel; Scientific Opinion on the risk posed by pathogens in food of non-animal origin. Part 1 (outbreak data analysis and risk ranking of food/pathogen combinations)

Food of non-animal origin (FoNAO) is consumed in a variety of forms, and a major component of almost all meals. These food types have the potential to be associated with large outbreaks as seen in 2011 associated with VTEC O104. A comparison of the incidence of human cases linked to consumption of FoNAO and of food of animal origin (FoAO) was carried out to provide an indication of the proportionality between these two groups of foods. It was concluded that outbreak data reported as part of EU Zoonoses Monitoring is currently the only option for EU-wide comparative estimates. Using this data from 2007 to 2011, FoNAO were associated with 10% of the outbreaks, 26% of the cases, 35% of the hospitalisations and 46% of the deaths. If the data from the 2011VTEC O104 outbreak is excluded, FoNAO was associated with 10% of the outbreaks, 18% of cases, but only 8% of the hospitalisations and 5% of the deaths. From 2008 to 2011 there was an increase in the numbers of reported outbreaks, cases, hospitalisations and deaths associated with food of non-animal origin. In order to identify and rank specific food/pathogen combinations most often linked to human cases originating from FoNAO in the EU, a model was developed using seven criteria: strength of associations between food and pathogen based on the foodborne outbreak data from EU Zoonoses Monitoring (2007-11), incidence of illness, burden of disease, dose-response relationship, consumption, prevalence of contamination and pathogen growth potential during shelf life. Shortcomings in the approach using outbreak data were discussed. The top ranking food/pathogen combination was Salmonellaspp. and leafy greens eaten raw followed by (in equal rank) Salmonellaspp. and bulb and stem vegetables, Salmonellaspp. and tomatoes, Salmonellaspp. and melons, and pathogenic Escherichia coli and fresh pods, legumes or grain