Replacement of dietary saturated fatty acids by trans fatty acids lowers serum HDL cholesterol and impairs endothelial function in healthy men and women

We tested whether trans fatty acids and saturated fatty acids had different effects on flow-mediated vasodilation (FMD), a risk marker of coronary heart disease (CHD). Consumption of trans fatty acids is related to increased risk of CHD, probably through effects on lipoproteins. Trans fatty acids differ from most saturated fatty acids because they decrease serum high-density lipoprotein (HDL) cholesterol, and this may increase the risk of CHD. We fed 29 volunteers 2 controlled diets in a 2x4-week randomized crossover design. The "Trans-diet" contained 9.2 energy percent of trans fatty acids; these were replaced by saturated fatty acids in the "Sat-diet." Mean serum HDL cholesterol after the Trans-diet was 0.39 mmol/L (14.8 mg/dL), or 21␕ower than after the Sat-diet (95␌I 0.28 to 0.50 mmol/L). Serum low density lipoprotein and triglyceride concentrations were stable. FMD SD was 4.4±2.3fter the Trans-diet and 6.2±3.0fter the Sat-diet (difference -1.8°95␌I -3.2 to -0.4). Replacement of dietary saturated fatty acids by trans fatty acids impaired FMD of the brachial artery, which suggests increased risk of CHD. Further studies are needed to test whether the decrease in serum HDL cholesterol caused the impairment of FMD

Trans fatty acids, HDL-cholesterol, and cardiovascular disease risk : effects of dietary changes on vascular reactivity

Intake of trans fatty acids increases the risk of coronary heart disease, even more so than saturated fatty acids. We wanted to investigate whether this higher risk was caused by the decrease in serum HDL-cholesterol by trans fatty acids. To do this, we studied the effect of diet-induced changes in HDL-cholesterol on vascular reactivity, a surrogate endpoint for coronary heart disease. Vascular reactivity was measured as flow-mediated vasodilation: the percentage increase in arterial diameter after a provoked increase in blood flow. The extent of flow-mediated vasodilation appears to be predictive of future coronary heart disease. The studies were performed in healthy men and women.Replacement of 9.2% of energy (en%) from saturated fatty acids by trans fatty acids lowered serum HDL-cholesterol after 4 weeks by 0.39 (95%CI 0.28, 0.50) mmol/L and impaired flow-mediated vasodilation from 6.2% to 4.4%, a decrease of 1.8%-points (0.4, 3.2). The activity of serum paraoxonase, an HDL-bound esterase which might protect against atherosclerosis, decreased by 6% (2%, 10%). We then verified whether a different HDL-lowering diet also impaired flow-mediated vasodilation. In this study, we replaced≈20en% monounsaturated fatty acids with carbohydrates: HDL-cholesterol decreased by 0.21 (0.17, 0.26) mmol/L and flow-mediated vasodilation increased from 4.1% to 4.8%, an increase of 0.7% (-0.6, 1.9). This result did not support our hypothesis that decreases in HDL-cholesterol increase risk of cardiovascular disease; however, the decrease might have been too small to cause an effect. We therefore investigated in an oral fat-loading test whether trans fatty acids could impair flow-mediated vasodilation while HDL-cholesterol was constant. This was not the case; flow-mediated vasodilation after an oral fat load of 1g/kg bodyweight was 3.1% versus 2.6% before, and trans fatty acids and saturated fatty acids had similar effects. Serum paraoxonase activity parallelled the change in flow-mediated vasodilation, and was slightly increased after an oral fat load with either trans or saturated fatty acids.We conclude that replacement of saturated fatty acids by trans fatty acids impairs vascular function within 4 weeks. This may explain why trans fatty acids relate more strongly to risk of cardiovascular disease than saturated fatty acids. Whether the effects on vascular function are caused by changes in HDL-cholesterol remains to be resolved.</font

Resultaten en ambities : proef de vooruitgang!

In 2007 namen Ziekenhuis Gelderse Vallei in Ede en de afdeling Humane Voeding van Wageningen University het initiatief tot samenwerking en vormden zij de Alliantie Voeding Gelderse Vallei. De Alliantie Voeding koppelt preventie aan zorg. Voor jong tot oud is voorlichting over gezonde voeding van belang. Effectieve preventie én de integratie van preventie in de zorg levert gezondheidswinst en verhoging van kwaliteit van leven op individueel en populatie niveau. De Alliantie Voeding heeft hiertoe drie programma's opgesteld

The effects of the multispecies probiotic mixture Ecologic®Barrier on migraine: results of an open-label pilot study

Migraine prevalence is associated with gastrointestinal disorders. Possible underlying mechanisms could be increased gut permeability and inflammation. Probiotics may decrease intestinal permeability as well as inflammation, and therefore may reduce the frequency and/or intensity of migraine attacks. Therefore we assessed feasibility, possible clinical efficacy, and adverse reactions of probiotic treatment in migraine patients. 29 migraine patients took 2 g/d of a probiotic food supplement (Ecologic®Barrier, 2.5×109 cfu/g) during 12 weeks. Participants recorded frequency and intensity of migraine in a headache diary and completed the Migraine Disability Assessment Scale (MIDAS) and Henry Ford Hospital Headache Disability Inventory (HDI) at baseline and after 12 weeks of treatment. Compliance was measured every 4 weeks by counting the remaining sachets with probiotics. The study was completed by 27/29 (93%) patients who took 95% of the supplements. Obstipation was reported by 4 patients during the first 2 weeks of treatment only. The mean±standard deviation (SD) number of migraine days/month decreased significantly from 6.7±2.4 at baseline to 5.1±2.2 (P=0.008) in week 5-8 and 5.2±2.4 in week 9-12 (P=0.001). The mean±SD intensity of migraine decreased significantly from 6.3±1.5 at baseline to 5.5±1.9 after treatment (P=0.005). The MIDAS score improved from 24.8±25.5 to 16.6±13.5 (P=0.031). However, the mean HDI did not change significantly. In conclusion, probiotics may decrease migraine supporting a possible role for the intestine in migraine management. Feasibility and lack of adverse reactions justify further placebo-controlled studies

Search for direct production of charginos and neutralinos in events with three leptons and missing transverse momentum in √s = 7 TeV pp collisions with the ATLAS detector

A search for the direct production of charginos and neutralinos in final states with three electrons or muons and missing transverse momentum is presented. The analysis is based on 4.7 fb−1 of proton–proton collision data delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with Standard Model expectations in three signal regions that are either depleted or enriched in Z-boson decays. Upper limits at 95% confidence level are set in R-parity conserving phenomenological minimal supersymmetric models and in simplified models, significantly extending previous results

Jet size dependence of single jet suppression in lead-lead collisions at sqrt(s(NN)) = 2.76 TeV with the ATLAS detector at the LHC

Measurements of inclusive jet suppression in heavy ion collisions at the LHC provide direct sensitivity to the physics of jet quenching. In a sample of lead-lead collisions at sqrt(s) = 2.76 TeV corresponding to an integrated luminosity of approximately 7 inverse microbarns, ATLAS has measured jets with a calorimeter over the pseudorapidity interval |eta| < 2.1 and over the transverse momentum range 38 < pT < 210 GeV. Jets were reconstructed using the anti-kt algorithm with values for the distance parameter that determines the nominal jet radius of R = 0.2, 0.3, 0.4 and 0.5. The centrality dependence of the jet yield is characterized by the jet "central-to-peripheral ratio," Rcp. Jet production is found to be suppressed by approximately a factor of two in the 10% most central collisions relative to peripheral collisions. Rcp varies smoothly with centrality as characterized by the number of participating nucleons. The observed suppression is only weakly dependent on jet radius and transverse momentum. These results provide the first direct measurement of inclusive jet suppression in heavy ion collisions and complement previous measurements of dijet transverse energy imbalance at the LHC.Comment: 15 pages plus author list (30 pages total), 8 figures, 2 tables, submitted to Physics Letters B. All figures including auxiliary figures are available at http://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/HION-2011-02

Search for dark matter produced in association with a hadronically decaying vector boson in pp collisions at sqrt (s) = 13 TeV with the ATLAS detector

A search is presented for dark matter produced in association with a hadronically decaying W or Z boson using 3.2 fb−1 of pp collisions at View the MathML sources=13 TeV recorded by the ATLAS detector at the Large Hadron Collider. Events with a hadronic jet compatible with a W or Z boson and with large missing transverse momentum are analysed. The data are consistent with the Standard Model predictions and are interpreted in terms of both an effective field theory and a simplified model containing dark matter

A search for resonances decaying into a Higgs boson and a new particle X in the XH → qqbb final state with the ATLAS detector

A search for heavy resonances decaying into a Higgs boson (H) and a new particle (X) is reported, utilizing 36.1 fb−1 of proton–proton collision data at collected during 2015 and 2016 with the ATLAS detector at the CERN Large Hadron Collider. The particle X is assumed to decay to a pair of light quarks, and the fully hadronic final state is analysed. The search considers the regime of high XH resonance masses, where the X and H bosons are both highly Lorentz-boosted and are each reconstructed using a single jet with large radius parameter. A two-dimensional phase space of XH mass versus X mass is scanned for evidence of a signal, over a range of XH resonance mass values between 1 TeV and 4 TeV, and for X particles with masses from 50 GeV to 1000 GeV. All search results are consistent with the expectations for the background due to Standard Model processes, and 95% CL upper limits are set, as a function of XH and X masses, on the production cross-section of the resonance

Measurement of the cross section for isolated-photon plus jet production in pp collisions at √s=13 TeV using the ATLAS detector

The dynamics of isolated-photon production in association with a jet in proton–proton collisions at a centre-of-mass energy of 13 TeV are studied with the ATLAS detector at the LHC using a dataset with an integrated luminosity of 3.2 fb−1. Photons are required to have transverse energies above 125 GeV. Jets are identified using the anti- algorithm with radius parameter and required to have transverse momenta above 100 GeV. Measurements of isolated-photon plus jet cross sections are presented as functions of the leading-photon transverse energy, the leading-jet transverse momentum, the azimuthal angular separation between the photon and the jet, the photon–jet invariant mass and the scattering angle in the photon–jet centre-of-mass system. Tree-level plus parton-shower predictions from Sherpa and Pythia as well as next-to-leading-order QCD predictions from Jetphox and Sherpa are compared to the measurements