73 research outputs found
The "Unintended Consequences" of Confederate Trade Legislation
The immediate purpose of this paper is to focus on how import and blockade regulations enacted by the Confederacy affected the course of the war in its final days, but the issue of the economic effects of blockades has broader implications. Economic policies have been used as weapons, at least since the times of Pericles' Megaran Decree in 432 B.C., and have probably only grown in importance as economies have grown less autarkic and more interdependent over time. Since 1790, there have been at least four major global wars that have involved prolonged fighting, heavy losses, and severe bouts of inflation: the Napoleonic Wars, the American Civil War, World War I, and World War II. In all four of these conflicts, embargoes and blockades were an important component of the war planning of the eventual victor.Macroeconomics; Transitional Economies
Railroads, engineers, and the developement of spatial economics in France
This articles traces a little-known French tradition in spatial economics that was advanced by state engineers who were trained at the Ecole des Ponts et Chaussées and worked for the State Corps engineers. Spurred in part by changes in power technology, especially the advent of the railroad, these engineers pioneered the spatial aspects of competition in a macroeconomic framework. The contribution of Jules Dupuit (1804 - 1866) and Emile Cheysson (1836 - 1910) are especially singled out for analysis, and are shown to have anticipated later important developments in spatial economic theory.
ARE ART AUCTION ESTIMATES BIASED?
ABSTRACT This paper considers whether pre-sale auction estimates are unbiased predictors of price when "no-sales" are considered utilizing a newly constructed sample of over 500 works by eight early 20 th century American artists. Unbiased pre-sale auction estimates in predicting price, while expected, are generally not supported in previous work, but these studies (excepting one) do not include no-sales in the calculations. In order to study the question we employ a standard approach that uses an inverse Mills ration arising from a sample selection probit, as suggested by We find that controlling for selection bias, pre-sale auction estimates appear to be biased downward and we offer possible reasons for this result
ARE ART AUCTION ESTIMATES BIASED? (forthcoming Southern Economic Journal: http://journal.southerneconomic.org/doi/abs
ABSTRACT This paper considers whether pre-sale auction estimates are unbiased predictors of price when "no-sales" are considered utilizing a newly constructed sample of over 500 works by eight early 20 th century American artists. Unbiased pre-sale auction estimates in predicting price, while expected, are generally not supported in previous work, but these studies (excepting one) do not include no-sales in the calculations. In order to study the question we employ a standard approach that uses an inverse Mills ration arising from a sample selection probit, as suggested by We find that controlling for selection bias, pre-sale auction estimates appear to be biased downward and we offer possible reasons for this result
Household Production and Consumption of News-Information Services: An Empirical Study
A dramatic decline in newspaper consumption has been observed in recent years. This paper offers a theoretical justification for this phenomenon based on the opportunity cost of household time. A rising labor force participation rate, which proxies the opportunity cost of household production, helps explain the observed decline in newspaper consumption in a simple empirical test.Household Production; Households; News; Newspapers; Service; Services
The morphology and biochemistry of nanostructures provide evidence for synthesis and signaling functions in human cerebrospinal fluid
<p>Abstract</p> <p>Background</p> <p>Cerebrospinal fluid (CSF) contacts many brain regions and may mediate humoral signaling distinct from synaptic neurotransmission. However, synthesis and transport mechanisms for such signaling are not defined. The purpose of this study was to investigate whether human CSF contains discrete structures that may enable the regulation of humoral transmission.</p> <p>Methods</p> <p>Lumbar CSF was collected prospectively from 17 participants: with no neurological or psychiatric disease, with Alzheimer's disease, multiple sclerosis, or migraine; and ventricular CSF from two cognitively healthy participants with long-standing shunts for congenital hydrocephalus. Cell-free CSF was subjected to ultracentrifugation to yield supernatants and pellets that were examined by transmission electron microscopy, shotgun protein sequencing, electrophoresis, western blotting, lipid analysis, enzymatic activity assay, and immuno-electron microscopy.</p> <p>Results</p> <p>Over 3,600 CSF proteins were identified from repeated shotgun sequencing of cell-free CSF from two individuals with Alzheimer's disease: 25% of these proteins are normally present in membranes. Abundant nanometer-scaled structures were observed in ultracentrifuged pellets of CSF from all 16 participants examined. The most common structures included synaptic vesicle and exosome components in 30-200 nm spheres and irregular blobs. Much less abundant nanostructures were present that derived from cellular debris. Nanostructure fractions had a unique composition compared to CSF supernatant, richer in omega-3 and phosphoinositide lipids, active prostanoid enzymes, and fibronectin.</p> <p>Conclusion</p> <p>Unique morphology and biochemistry features of abundant and discrete membrane-bound CSF nanostructures are described. Prostaglandin H synthase activity, essential for prostanoid production and previously unknown in CSF, is localized to nanospheres. Considering CSF bulk flow and its circulatory dynamics, we propose that these nanostructures provide signaling mechanisms <it>via </it>volume transmission within the nervous system that are for slower, more diffuse, and of longer duration than synaptic transmission.</p
Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.
BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700
Rising rural body-mass index is the main driver of the global obesity epidemic in adults
Body-mass index (BMI) has increased steadily in most countries in parallel with a rise in the proportion of the population who live in cities(.)(1,2) This has led to a widely reported view that urbanization is one of the most important drivers of the global rise in obesity(3-6). Here we use 2,009 population-based studies, with measurements of height and weight in more than 112 million adults, to report national, regional and global trends in mean BMI segregated by place of residence (a rural or urban area) from 1985 to 2017. We show that, contrary to the dominant paradigm, more than 55% of the global rise in mean BMI from 1985 to 2017-and more than 80% in some low- and middle-income regions-was due to increases in BMI in rural areas. This large contribution stems from the fact that, with the exception of women in sub-Saharan Africa, BMI is increasing at the same rate or faster in rural areas than in cities in low- and middle-income regions. These trends have in turn resulted in a closing-and in some countries reversal-of the gap in BMI between urban and rural areas in low- and middle-income countries, especially for women. In high-income and industrialized countries, we noted a persistently higher rural BMI, especially for women. There is an urgent need for an integrated approach to rural nutrition that enhances financial and physical access to healthy foods, to avoid replacing the rural undernutrition disadvantage in poor countries with a more general malnutrition disadvantage that entails excessive consumption of low-quality calories.Peer reviewe
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