Spatial variability of chemical and agronomic attributes of soil in wheat seed production field

The need to rationalize the use of fertilizers and other chemicals, and financial resources has generated, increasingly, research in order to describe the spatial variability of soil properties in crops. This study aimed to study the spatial organization of soil properties in a wheat seed production field in an area of 11 ha in Lavras do Sul, RS, Brazil. Collecting soil four subsamples for chemical analysis and 10 for compression using a 100m X 100m grid by sampling was performed. Descriptive analysis and geostatistical was performed to characterize the samples and identify the spatial dependence of the studied attributes. From the results obtained maps were drawn by "Agricultural System CR-Campeiro 7" software. The greater variability checked by coefficient of variation was observed for the phosphorus content, the other had medium and low variability. All attributes have moderate spatial dependence and range equal to or above the maximum search radius.The need to rationalize the use of fertilizers and other chemicals, and financial resources has generated, increasingly, research in order to describe the spatial variability of soil properties in crops. This study aimed to study the spatial organization of soil properties in a wheat seed production field in an area of 11 ha. We collected four soil subsamples for chemical analysis and 10 samples for soil compression, using a 100 x 100 m grid. Descriptive and geostatistical analysis were performed to characterize the samples and identify the spatial dependence of the studied attributes. From the results obtained maps were drawn by “Agricultural System CR-Campeiro 7” software. The spatial organization of the evaluated attributes was heterogeneous. The chemical and physical attributes of the soil presented low or moderate spatial variability and moderate spatial dependence. The use of thematic map techniques can be used to optimize areas of wheat seed production

De novo design of potent and resilient hACE2 decoys to neutralize SARS-CoV-2

We developed a de novo protein design strategy to swiftly engineer decoys for neutralizing pathogens that exploit extracellular host proteins to infect the cell. Our pipeline allowed the design, validation, and optimization of de novo hACE2 decoys to neutralize SARS-CoV-2. The best decoy, CTC-445.2, binds with low nanomolar affinity and high specificity to the RBD of the spike protein. Cryo-EM shows that the design is accurate and can simultaneously bind to all three RBDs of a single spike protein. Because the decoy replicates the spike protein target interface in hACE2, it is intrinsically resilient to viral mutational escape. A bivalent decoy, CTC-445.2d, shows ~10-fold improvement in binding. CTC-445.2d potently neutralizes SARS-CoV-2 infection of cells in vitro and a single intranasal prophylactic dose of decoy protected Syrian hamsters from a subsequent lethal SARS-CoV-2 challenge

De novo design of potent and resilient hACE2 decoys to neutralize SARS-CoV-2

We developed a de novo protein design strategy to swiftly engineer decoys for neutralizing pathogens that exploit extracellular host proteins to infect the cell. Our pipeline allowed the design, validation, and optimization of de novo hACE2 decoys to neutralize SARS-CoV-2. The best decoy, CTC-445.2, binds with low nanomolar affinity and high specificity to the RBD of the spike protein. Cryo-EM shows that the design is accurate and can simultaneously bind to all three RBDs of a single spike protein. Because the decoy replicates the spike protein target interface in hACE2, it is intrinsically resilient to viral mutational escape. A bivalent decoy, CTC-445.2d, shows ~10-fold improvement in binding. CTC-445.2d potently neutralizes SARS-CoV-2 infection of cells in vitro and a single intranasal prophylactic dose of decoy protected Syrian hamsters from a subsequent lethal SARS-CoV-2 challenge

INNOVA Research Journal

La clase de matemáticas está en un proceso de evolución, las clases tradicionales centradas en el profesor van perdiendo vigencia en la educación ecuatoriana, dando paso a clases que priorizan al estudiante y sus aprendizajes. Tradicionalmente el docente de matemáticas ha tenido formación profesional en áreas técnicas y poca capacitación en aspectos pedagógicos que le den habilidades para llevar adelante una clase fundada en paradigmas constructivistas del aprendizaje, centrados en el estudiante y la calidad de sus aprendizajes. Una clase constructivista de matemáticas implica tener un estudiante con una visión diferente a su formación tradicional, debe estar motivado por alcanzar aprendizajes significativos, para esto debe ser capaz de investigar, analizar, reflexionar, plantear soluciones creativas, resolver situaciones del contexto, formado en valores y que aporta al crecimiento de la sociedad

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

A logística reversa em uma indústria alimentícia: estudo de caso

O presente trabalho aborda um estudo de caso sobre os fatores que influenciam o retorno indevido de biscoitos dos varejistas do sul do Estado de Minas Gerais, realizado em uma indústria de médio porte produtora deste item. As justificativas são expostas para a realização do estudo, fundamentação teórica acerca da logística reversa, canais de distribuição, gestão de vendas e estoques, bem como roteirização. Para a aplicação do estudo, utilizaram-se questionários e entrevistas com o gestor da empresa, os quais visavam entender como o processo de gestão de vendas afetava o retorno de biscoitos e a lucratividade da empresa.&nbsp

As ações do núcleo de monitoramento de penas alternativas no município de Londrina

This article intends to present the “Nucleus of Management of Alternative Punishments of Londrina”, whore aim is to offer a multidisciplinary work of attention and attendance to drugs users sanctioned by de article 28, law 11.343/06. Therefore, the text brings some considerations about alternative punishments, the new drugs law, and an analysis about the thematic associated with the field of action of the project team. Furthermore, we present the “Núcleo” and the work developed there also the importance and the validity of congener initiatives, in order to concretize the reparatory potential of alternative punishment, continuing the developments of de law, and the attendance to the drugs users sanctioned.O presente artigo tem, por objetivo, apresentar o Núcleo de Monitoramento de Penas Alternativas de Londrina, cuja proposta é oferecer um trabalho multidisciplinar de atenção e de acompanhamento do processo de cumprimento da pena, aos usuários de drogas, sancionados nos termos do artigo 28, da Lei 11.343/06. Tendo isso em vista, o texto traz algumas considerações sobre as penas alternativas, a nova Lei de Drogas e analisa temáticas diretamente associadas ao campo específico de ação da Equipe do Projeto. Fazemos ainda uma apresentação do Núcleo e do trabalho desenvolvido, apresentando a importância e a validade de iniciativas congêneres, para a concretizar o potencial reinseridor das penas alternativas, para dar continuidade aos avanços empreendidos pela lei e ainda, para atender, de modo eficaz, aos usuários de drogas, sancionados

Massively parallel de novo protein design for targeted therapeutics

De novo protein design holds promise for creating small stable proteins with shapes customized to bind therapeutic targets. We describe a massively parallel approach for designing, manufacturing and screening mini-protein binders, integrating large-scale computational design, oligonucleotide synthesis, yeast display screening and next-generation sequencing. We designed and tested 22,660 mini-proteins of 37-43 residues that target influenza haemagglutinin and botulinum neurotoxin B, along with 6,286 control sequences to probe contributions to folding and binding, and identified 2,618 high-affinity binders. Comparison of the binding and non-binding design sets, which are two orders of magnitude larger than any previously investigated, enabled the evaluation and improvement of the computational model. Biophysical characterization of a subset of the binder designs showed that they are extremely stable and, unlike antibodies, do not lose activity after exposure to high temperatures. The designs elicit little or no immune response and provide potent prophylactic and therapeutic protection against influenza, even after extensive repeated dosing