A multi-country test of brief reappraisal interventions on emotions during the COVID-19 pandemic.

The COVID-19 pandemic has increased negative emotions and decreased positive emotions globally. Left unchecked, these emotional changes might have a wide array of adverse impacts. To reduce negative emotions and increase positive emotions, we tested the effectiveness of reappraisal, an emotion-regulation strategy that modifies how one thinks about a situation. Participants from 87 countries and regions (n = 21,644) were randomly assigned to one of two brief reappraisal interventions (reconstrual or repurposing) or one of two control conditions (active or passive). Results revealed that both reappraisal interventions (vesus both control conditions) consistently reduced negative emotions and increased positive emotions across different measures. Reconstrual and repurposing interventions had similar effects. Importantly, planned exploratory analyses indicated that reappraisal interventions did not reduce intentions to practice preventive health behaviours. The findings demonstrate the viability of creating scalable, low-cost interventions for use around the world

Inhibition of brain [(3)H]cimetidine binding by improgan-like antinociceptive drugs

[(3)H]cimetidine, a radiolabeled histamine H(2) receptor antagonist, binds with high affinity to an unknown hemoprotein in the brain which is not the histamine H(2) receptor. Improgan, a close chemical congener of cimetidine, is a highly effective pain-relieving drug following CNS administration, yet its mechanism of action remains unknown. To test the hypothesis that the [(3)H]cimetidine-binding site is the improgan antinociceptive target, improgan, cimetidine, and 8 other chemical congeners were studied as potential inhibitors of [(3)H]cimetidine binding in membrane fractions from the rat brain. All compounds produced a concentration-dependent inhibition of [(3)H]cimetidine binding over a 500-fold range of potencies (K(i) values were 14.5 to >8000nM). However, antinociceptive potencies in rats did not significantly correlate with [(3)H]cimetidine-binding affinities (r=0.018, p=0.97, n=10). These results suggest that the [(3)H]cimetidine-binding site is not the analgesic target for improgan-like drugs

CC12, a high-affinity ligand for [3H]cimetidine binding, is an improgan antagonist

Improgan, a chemical congener of cimetidine, is a highly effective non-opioid analgesic when injected into the CNS. Despite extensive characterization, neither the improgan receptor, nor a pharmacological antagonist of improgan has been previously described. Presently, the specific binding of [(3)H]cimetidine (3HCIM) in brain fractions was used to discover 4(5)-((4-iodobenzyl)thiomethyl)-1H-imidazole, which behaved in vivo as the first improgan antagonist. The synthesis and pharmacological properties of this drug (named CC12) are described herein. In rats, CC12 (50-500nmol, i.c.v.) produced dose-dependent inhibition of improgan (200-400nmol) antinociception on the tail flick and hot plate tests. When given alone to rats, CC12 had no effects on nociceptive latencies, or on other observable behavioral or motor functions. Maximal inhibitory effects of CC12 (500nmol) were fully surmounted with a large i.c.v. dose of improgan (800nmol), demonstrating competitive antagonism. In mice, CC12 (200-400nmol, i.c.v.) behaved as a partial agonist, producing incomplete improgan antagonism, but also limited antinociception when given alone. Radioligand binding, receptor autoradiography, and electrophysiology experiments showed that CC12's antagonist properties are not explained by activity at 25 sites relevant to analgesia, including known receptors for cannabinoids, opioids or histamine. The use of CC12 as an improgan antagonist will facilitate the characterization of improgan analgesia. Furthermore, because CC12 was also found presently to inhibit opioid and cannabinoid antinociception, it is suggested that this drug modifies a biochemical mechanism shared by several classes of analgesics. Elucidation of this mechanism will enhance understanding of the biochemistry of pain relief

Tears evoke the intention to offer social support: A systematic investigation of the interpersonal effects of emotional crying across 41 countries

Tearful crying is a ubiquitous and likely uniquely human phenomenon. Scholars have argued that emotional tears serve an attachment function: Tears are thought to act as a social glue by evoking social support intentions. Initial experimental studies supported this proposition across several methodologies, but these were conducted almost exclusively on participants from North America and Europe, resulting in limited generalizability. This project examined the tears-social support intentions effect and possible mediating and moderating variables in a fully pre-registered study across 7007 participants (24,886 ratings) and 41 countries spanning all populated continents. Participants were presented with four pictures out of 100 possible targets with or without digitally-added tears. We confirmed the main prediction that seeing a tearful individual elicits the intention to support, d = 0.49 [0.43, 0.55]. Our data suggest that this effect could be mediated by perceiving the crying target as warmer and more helpless, feeling more connected, as well as feeling more empathic concern for the crier, but not by an increase in personal distress of the observer. The effect was moderated by the situational valence, identifying the target as part of one's group, and trait empathic concern. A neutral situation, high trait empathic concern, and low identification increased the effect. We observed high heterogeneity across countries that was, via split-half validation, best explained by country-level GDP per capita and subjective well-being with stronger effects for higher-scoring countries. These findings suggest that tears can function as social glue, providing one possible explanation why emotional crying persists into adulthood.Fil: Zickfeld, Janis H.. University Aarhus; DinamarcaFil: van de Ven, Niels. Tilburg University; Países BajosFil: Pich, Olivia. University of Oslo; NoruegaFil: Schubert, Thomas W.. University of Oslo; Noruega. INSTITUTO UNIVERSITARIO DE LISBOA (IUL);Fil: Berkessel, Jana B.. Universität Mannheim; AlemaniaFil: Pizarro, José J.. Universidad del País Vasco; EspañaFil: Bhushan, Braj. Indian Institute of Technology Kanpur; IndiaFil: Mateo, Nino Jose. de la Salle University; FilipinasFil: Barbosa, Sergio. Universidad Colegio Mayor de Nuestra Señora del Rosario; ColombiaFil: Sharman, Leah. The University of Queensland; AustraliaFil: Kökönyei, Gyöngyi. Semmelweis University; Hungría. ELTE Eötvös Loránd University; HungríaFil: Schrover, Elke. Tilburg University; Países BajosFil: Kardum, Igor. University of Rijeka; CroaciaFil: Aruta, John Jamir Benzon. de la Salle University; FilipinasFil: Lazarevic, Ljiljana B.. University Of Belgrade; SerbiaFil: Escobar, María Josefina. Universidad Adolfo Ibáñez; ChileFil: Stadel, Marie. Rijksuniversiteit Groningen; Países BajosFil: Arriaga, Patrícia. INSTITUTO UNIVERSITARIO DE LISBOA (IUL);Fil: Dodaj, Arta. University of Zadar; CroaciaFil: Shankland, Rebecca. Universite Grenoble Alpes; FranciaFil: Majeed, Nadyanna M.. Singapore Management University; SingapurFil: Li, Yansong. Nanjing University; ChinaFil: Lekkou, Eleimonitria. Panteion University of Social and Political Sciences; GreciaFil: Hartanto, Andree. Singapore Management University; SingapurFil: Özdoğru, Asil A.. Üsküdar Üniversitesi; TurquíaFil: Vaughn, Leigh Ann. Ithaca College; Estados UnidosFil: del Carmen Espinoza, Maria. Universidad de Lima; PerúFil: Caballero, Amparo. Universidad Autónoma de Madrid; EspañaFil: Kolen, Anouk. Tilburg University; Países BajosFil: García, Adolfo Martín. Universidad de San Andrés. Departamento de Matemáticas y Ciencias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin

Tears evoke the intention to offer social support: A systematic investigation of the interpersonal effects of emotional crying across 41 countries

From Elsevier via Jisc Publications RouterHistory: accepted 2021-03-18, epub 2021-04-13, issue date 2021-07-31Article version: AMPublication status: PublishedFunder: National Science Centre, Poland; FundRef: https://doi.org/10.13039/501100004281; Grant(s): 2015/19/D/HS6/00641, 2019/35/B/HS6/00528Funder: Polish National Agency for Academic Exchange; Grant(s): PPN/BEK/2019/1/00092/DEC/1Funder: Portuguese Foundation for Science and Technology; Grant(s): UID/PSI/03125/2020Funder: Hungarian National Research, Development and Innovation Office; Grant(s): FK128614Funder: Hungarian Brain Research Programme; Grant(s): 2017-1.2.1-NKP-2017-00002Funder: Open University of Israel; FundRef: https://doi.org/10.13039/100008509; Grant(s): 509993-2018Tearful crying is a ubiquitous and likely uniquely human phenomenon. Scholars have argued that emotional tears serve an attachment function: Tears are thought to act as a social glue by evoking social support intentions. Initial experimental studies supported this proposition across several methodologies, but these were conducted almost exclusively on participants from North America and Europe, resulting in limited generalizability. This project examined the tears-social support intentions effect and possible mediating and moderating variables in a fully pre-registered study across 7007 participants (24,886 ratings) and 41 countries spanning all populated continents. Participants were presented with four pictures out of 100 possible targets with or without digitally-added tears. We confirmed the main prediction that seeing a tearful individual elicits the intention to support, d = 0.49 [0.43, 0.55]. Our data suggest that this effect could be mediated by perceiving the crying target as warmer and more helpless, feeling more connected, as well as feeling more empathic concern for the crier, but not by an increase in personal distress of the observer. The effect was moderated by the situational valence, identifying the target as part of one's group, and trait empathic concern. A neutral situation, high trait empathic concern, and low identification increased the effect. We observed high heterogeneity across countries that was, via split-half validation, best explained by country-level GDP per capita and subjective well-being with stronger effects for higher-scoring countries. These findings suggest that tears can function as social glue, providing one possible explanation why emotional crying persists into adulthood