Outflow of hot and cold molecular gas from the obscured secondary nucleus of NGC3256: closing in on feedback physics

The nuclei of merging galaxies are often deeply buried in dense layers of gas and dust. In these regions, gas outflows driven by starburst and AGN activity are believed to play a crucial role in the evolution of these galaxies. However, to fully understand this process it is essential to resolve the morphology and kinematics of such outflows. Using near-IR integral-field spectroscopy obtained with VLT/SINFONI, we detect a kpc-scale structure of high-velocity molecular hydrogen (H2) gas associated with the deeply buried secondary nucleus of the IR-luminous merger NGC3256. We show that this structure is likely the hot component of a molecular outflow, which is detected also in the cold molecular gas by Sakamoto et al. This outflow, with a molecular gas mass of M(H2)~2x10^7 Msun, is among the first to be spatially resolved in both the hot H2 gas with VLT/SINFONI and the cold CO-emitting gas with ALMA. The hot and cold components share a similar morphology and kinematics, with a hot-to-cold molecular gas mass ratio of ~6x10^-5. The high (~100 pc) resolution at which we map the geometry and velocity structure of the hot outflow reveals a biconical morphology with opening angle ~40 deg and gas spread across a FWZI~1200 km/s. Because this collimated outflow is oriented close to the plane of the sky, the molecular gas may reach maximum intrinsic outflow velocities of ~1800 km/s, with an average mass outflow rate of at least ~20 Msun/yr. By modeling the line-ratios of various near-IR H2 transitions, we show that the H2 gas in the outflow is heated through shocks or X-rays to a temperature of ~1900K. The energy needed to drive the outflow is likely provided by a hidden Compton-thick AGN or by the nuclear starburst. We show that the global kinematics of the molecular outflow in NGC3256 mimic those of CO-outflows that have been observed at low spatial resolution in starburst- and active galaxies.Comment: Accepted in Astronomy and Astrophysics (accepted 29 Aug 2014 v.3, initial submission v.1 14 March 2014), 13 pages, 8 figure

Formation of b-Bi2O3 and d-Bi2O3 during laser irradiation of Bi films studied in-situ by spatially resolved Raman spectroscopy

The formation of different phases of Bi2O3 induced by laser irradiation of Bi films has been assessed in situ by micro-Raman spectroscopy as a function of laser wavelength, power density and irradiation time. Raman mapping of the irradiated samples enabled a spatially-resolved study of the distribution of the formed Bi2O3 phases. Red laser (633 nm) irradiation was found to induce the appearance of b-Bi2O3, within a certain range of power densities, by diffusion-controlled processes. In contrast, ultraviolet (UV, 325 nm) laser irradiation, above a certain power density threshold, initially induces the formation of both b and d-Bi2O3 phases. The amount of the produced d-Bi2O3 phase increases by increasing the irradiation time, while that of the b phase follows the opposite trend. UV laser irradiation seems to be a suitable method to produce room temperature stable d-Bi2O3 patterns on Bi film

Modelo metodológico basado en “Social Design”, aplicación práctica, imagen y comunicación de resultados

Durante los estudios del Grado en Diseño industrial y desarrollo de producto se conocen y trabajan con diferentes metodologías, pero existen nuevas e incipientes metodologías que se incorporan a estas ya existentes con nuevas orientaciones que complementan las actuales. Social Design es una nueva metodología que plantea la actividad de diseño como una estrategia de mejora social, pretende realizar acciones y actividades sociales diseñadas de modo que la sociedad obtenga unos beneficios como grupo o sistema. Además es necesario hacer planteamientos divulgativos de estas nuevas metodologías y se plantea que los resultados del modelo propuesto se apoyen con el diseño de una imagen y campaña de comunicación. Existen referencia y casos de experiencias previas que validan esta metodología, pero aún no está completamente consolidada y es posible plantear mejoras o adaptaciones a necesidades concretas. Se pretende como objetivo plantear un modelo metodológico de SD aplicable a un caso concreto en el que se resuelve el diseño y la comunicación de los resultados

Natural History of MYH7-Related Dilated Cardiomyopathy

BACKGROUND Variants in myosin heavy chain 7 (MYH7) are responsible for disease in 1% to 5% of patients with dilated cardiomyopathy (DCM); however, the clinical characteristics and natural history of MYH7-related DCM are poorly described. OBJECTIVES We sought to determine the phenotype and prognosis of MYH7-related DCM. We also evaluated the influence of variant location on phenotypic expression. METHODS We studied clinical data from 147 individuals with DCM-causing MYH7 variants (47.6% female; 35.6 +/- 19.2 years) recruited from 29 international centers. RESULTS At initial evaluation, 106 (72.1%) patients had DCM (left ventricular ejection fraction: 34.5% +/- 11.7%). Median follow-up was 4.5 years (IQR: 1.7-8.0 years), and 23.7% of carriers who were initially phenotype-negative developed DCM. Phenotypic expression by 40 and 60 years was 46% and 88%, respectively, with 18 patients (16%) first diagnosed at <18 years of age. Thirty-six percent of patients with DCM met imaging criteria for LV noncompaction. During follow-up, 28% showed left ventricular reverse remodeling. Incidence of adverse cardiac events among patients with DCM at 5 years was 11.6%, with 5 (4.6%) deaths caused by end-stage heart failure (ESHF) and 5 patients (4.6%) requiring heart transplantation. The major ventricular arrhythmia rate was low (1.0% and 2.1% at 5 years in patients with DCM and in those with LVEF of <= 35%, respectively). ESHF and major ventricular arrhythmia were significantly lower compared with LMNA-related DCM and similar to DCM caused by TTN truncating variants. CONCLUSIONS MYH7-related DCM is characterized by early age of onset, high phenotypic expression, low left ventricular reverse remodeling, and frequent progression to ESHF. Heart failure complications predominate over ventricular arrhythmias, which are rare. (C) 2022 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation

Risk factors associated with adverse fetal outcomes in pregnancies affected by Coronavirus disease 2019 (COVID-19): a secondary analysis of the WAPM study on COVID-19.

Objectives To evaluate the strength of association between maternal and pregnancy characteristics and the risk of adverse perinatal outcomes in pregnancies with laboratory confirmed COVID-19. Methods Secondary analysis of a multinational, cohort study on all consecutive pregnant women with laboratory-confirmed COVID-19 from February 1, 2020 to April 30, 2020 from 73 centers from 22 different countries. A confirmed case of COVID-19 was defined as a positive result on real-time reverse-transcriptase-polymerase-chain-reaction (RT-PCR) assay of nasal and pharyngeal swab specimens. The primary outcome was a composite adverse fetal outcome, defined as the presence of either abortion (pregnancy loss before 22 weeks of gestations), stillbirth (intrauterine fetal death after 22 weeks of gestation), neonatal death (death of a live-born infant within the first 28 days of life), and perinatal death (either stillbirth or neonatal death). Logistic regression analysis was performed to evaluate parameters independently associated with the primary outcome. Logistic regression was reported as odds ratio (OR) with 95% confidence interval (CI). Results Mean gestational age at diagnosis was 30.6+/-9.5 weeks, with 8.0% of women being diagnosed in the first, 22.2% in the second and 69.8% in the third trimester of pregnancy. There were six miscarriage (2.3%), six intrauterine device (IUD) (2.3) and 5 (2.0%) neonatal deaths, with an overall rate of perinatal death of 4.2% (11/265), thus resulting into 17 cases experiencing and 226 not experiencing composite adverse fetal outcome. Neither stillbirths nor neonatal deaths had congenital anomalies found at antenatal or postnatal evaluation. Furthermore, none of the cases experiencing IUD had signs of impending demise at arterial or venous Doppler. Neonatal deaths were all considered as prematurity-related adverse events. Of the 250 live-born neonates, one (0.4%) was found positive at RT-PCR pharyngeal swabs performed after delivery. The mother was tested positive during the third trimester of pregnancy. The newborn was asymptomatic and had negative RT-PCR test after 14 days of life. At logistic regression analysis, gestational age at diagnosis (OR: 0.85, 95% CI 0.8-0.9 per week increase; pPeer reviewe

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements

Combinations of single-top-quark production cross-section measurements and vertical bar f(LV)V(tb)vertical bar determinations at root s=7 and 8 TeV with the ATLAS and CMS experiments

This paper presents the combinations of single-top-quark production cross-section measurements by the ATLAS and CMS Collaborations, using data from LHC proton-proton collisions at = 7 and 8 TeV corresponding to integrated luminosities of 1.17 to 5.1 fb(-1) at = 7 TeV and 12.2 to 20.3 fb(-1) at = 8 TeV. These combinations are performed per centre-of-mass energy and for each production mode: t-channel, tW, and s-channel. The combined t-channel cross-sections are 67.5 +/- 5.7 pb and 87.7 +/- 5.8 pb at = 7 and 8 TeV respectively. The combined tW cross-sections are 16.3 +/- 4.1 pb and 23.1 +/- 3.6 pb at = 7 and 8 TeV respectively. For the s-channel cross-section, the combination yields 4.9 +/- 1.4 pb at = 8 TeV. The square of the magnitude of the CKM matrix element V-tb multiplied by a form factor f(LV) is determined for each production mode and centre-of-mass energy, using the ratio of the measured cross-section to its theoretical prediction. It is assumed that the top-quark-related CKM matrix elements obey the relation |V-td|, |V-ts| << |V-tb|. All the |f(LV)V(tb)|(2) determinations, extracted from individual ratios at = 7 and 8 TeV, are combined, resulting in |f(LV)V(tb)| = 1.02 +/- 0.04 (meas.) +/- 0.02 (theo.). All combined measurements are consistent with their corresponding Standard Model predictions.Peer reviewe