922 research outputs found
White adipose remodeling during browning in mice involves YBX1 to drive thermogenic commitment
- Author
- Publication venue
- Scholarly Commons
- Publication date
- 01/02/2021
- Field of study
Objective: Increasing adaptive thermogenesis by stimulating browning in white adipose tissue is a promising method of improving metabolic health. However, the molecular mechanisms underlying this transition remain elusive. Our study examined the molecular determinants driving the differentiation of precursor cells into thermogenic adipocytes. Methods: In this study, we conducted temporal high-resolution proteomic analysis of subcutaneous white adipose tissue (scWAT) after cold exposure in mice. This was followed by loss- and gain-of-function experiments using siRNA-mediated knockdown and CRISPRa-mediated induction of gene expression, respectively, to evaluate the function of the transcriptional regulator Y box-binding protein 1 (YBX1) during adipogenesis of brown pre-adipocytes and mesenchymal stem cells. Transcriptomic analysis of mesenchymal stem cells following induction of endogenous Ybx1 expression was conducted to elucidate transcriptomic events controlled by YBX1 during adipogenesis. Results: Our proteomics analysis uncovered 509 proteins differentially regulated by cold in a time-dependent manner. Overall, 44 transcriptional regulators were acutely upregulated following cold exposure, among which included the cold-shock domain containing protein YBX1, peaking after 24 h. Cold-induced upregulation of YBX1 also occurred in brown adipose tissue, but not in visceral white adipose tissue, suggesting a role of YBX1 in thermogenesis. This role was confirmed by Ybx1 knockdown in brown and brite preadipocytes, which significantly impaired their thermogenic potential. Conversely, inducing Ybx1 expression in mesenchymal stem cells during adipogenesis promoted browning concurrent with an increased expression of thermogenic markers and enhanced mitochondrial respiration. At a molecular level, our transcriptomic analysis showed that YBX1 regulates a subset of genes, including the histone H3K9 demethylase Jmjd1c, to promote thermogenic adipocyte differentiation. Conclusion: Our study mapped the dynamic proteomic changes of murine scWAT during browning and identified YBX1 as a novel factor coordinating the genomic mechanisms by which preadipocytes commit to brite/beige lineage
Clinical Sequencing Exploratory Research Consortium: Accelerating Evidence-Based Practice of Genomic Medicine
- Author
- Amaral Michelle
- Amendola Laura
- Amendola Laura M.
- Appelbaum Paul S.
- Appelbaum Paul S.
- Aronson Samuel J.
- Arora Shubhangi
- Azzariti Danielle R.
- Barsh Greg S.
- Bebin E.M.
- Berg Jonathan S.
- Bernhardt Barbara A.
- Biesecker Barbara B.
- Biesecker Leslie G.
- Biesecker Leslie G.
- Biswas Sawona
- Biswas Sawona
- Blout Carrie L.
- Blout Carrie L.
- Bowling Kevin M.
- Bowling Kevin M.
- Breitkopf Carmen Radecki
- Brothers Kyle B.
- Brothers Kyle B.
- Brown Brian L.
- Burke Wylie
- Burt Amber A.
- Byers Peter H.
- Caga-anan Charlisse F.
- Caga-anan Charlisse F.
- Calikoglu Muge G.
- Carlson Sara J.
- Chahin Nizar
- Chinnaiyan Arul M.
- Chinnaiyan Arul M.
- Christensen Kurt D.
- Chung Wendy
- Chung Wendy K.
- Cirino Allison L.
- Clayton Ellen
- Clayton Ellen W.
- Conlin Laura K.
- Cooper Gregory M.
- Cooper Greg M.
- Crosslin David R.
- Davis James V.
- Davis Kelly
- Deardorff Matthew A.
- Devkota Batsal
- De Vries Raymond
- Diamond Pamela
- Dorschner Michael O.
- Dugan Noreen P.
- Dukhovny Dmitry
- Dulik Matthew C.
- East Kelly
- East Kelly M.
- Evans Barbara
- Evans James P.
- Evans James P.
- Everett Jessica
- Exe Nicole
- Fan Zheng
- Feuerman Lindsay Z.
- Filipski Kelly
- Finnila Candice R.
- Fishler Kristen
- Fullerton Stephanie M.
- Fullerton Stephanie M.
- Garraway Levi A.
- Garrett Jeremy R.
- Ghrundmeier Bob
- Giles Karen
- Gilmore Marian J.
- Girnary Zahra S.
- Goddard Katrina
- Goddard Katrina A.B.
- Gonsalves Steven
- Gordon Adam S.
- Gornick Michele C.
- Grady William M.
- Gray David E.
- Gray Stacy W.
- Gray Stacy W.
- Green Robert
- Green Robert C.
- Greenwood Robert S.
- Gutierrez Amanda M.
- Han Paul
- Hart Ragan
- Heagerty Patrick
- Henderson Gail E.
- Henderson Gail E.
- Hensman Naomi
- Hiatt Susan M.
- Himes Patricia
- Hindorff Lucia A.
- Hindorff Lucia A.
- Hisama Fuki M.
- Ho Carolyn Y.
- Hoffman-Andrews Lily B.
- Holm Ingrid A.
- Holm Ingrid A.
- Hong Celine
- Horike-Pyne Martha J.
- Hull Sara
- Hutter Carolyn M.
- Hutter Carolyn M.
- Jamal Seema
- Janne Pasi A.
- Jarvik Gail P.
- Jarvik Gail P.
- Jensen Brian C.
- Joffe Steve
- Joffe Steven
- Johnston Jennifer
- Karavite Dean
- Kauffman Tia L.
- Kaufman Dave
- Kaufman David
- Kelley Whitley
- Kim Jerry H.
- Kirby Christine
- Klein William
- Knoppers Bartha
- Knoppers Bartha M.
- Koenig Barbara A.
- Koenig Barbara A.
- Kong Sek Won
- Krantz Ian
- Krantz Ian D.
- Krier Joel B.
- Lamb Neil E.
- Lambert Michele P.
- Le Lan Q.
- Lebo Matthew S.
- Lee Alexander
- Lee Kaitlyn B.
- Lennon Niall
- Leo Michael C.
- Leppig Kathleen A.
- Lewis Katie
- Lewis Michelle
- Lewis Michelle Huckaby
- Lindeman Neal I.
- Lockhart Nicole
- Lonigro Bob
- Lose Edward J.
- Lupo Philip J.
- Lynch Frances
- Machini Kalotina
- MacRae Calum
- Manolio Teri A.
- Manolio Teri A.
- Marchuk Daniel S.
- Martinez Josue N.
- Masino Aaron
- McCullough Laurence
- McCullough Laurence
- McEwen Jean
- McEwen Jean
- McGuire Amy
- McGuire Amy
- McLaughlin Heather M.
- McMullen Carmit
- Mieczkowski Piotr A.
- Miller Jeff
- Miller Victoria A.
- Mody Rajen
- Mooney Sean D.
- Moore Elizabeth G.
- Morris Elissa
- Murray Michael
- Muzny Donna
- Muzny Donna
- Myers Richard M.
- Myers Richard M.
- Ng David
- Nickerson Deborah A.
- Nickerson Deborah A.
- Oliver Nelly M.
- Ou Jeffrey
- Ou Jeffrey
- Parsons Donald W.
- Parsons Will
- Patrick Donald L.
- Pennington Jeffrey
- Perry Denise L.
- Petersen Gloria
- Petersen Gloria M.
- Plon Sharon
- Plon Sharon E.
- Porter Katie
- Powell Bradford C.
- Punj Sumit
- Raesz-Martinez Robin A.
- Raskind Wendy H.
- Rehm Heidi L.
- Rehm Heidi L.
- Reigar Dean A.
- Reiss Jacob A.
- Rich Carla A.
- Richards Carolyn Sue
- Rini Christine
- Rivera-Munoz Edgar A.
- Roberts J. Scott
- Roberts Scott
- Robertson Peggy D.
- Robinson Dan
- Robinson Dan
- Robinson Jill O.
- Robinson Marguerite E.
- Roche Myra I.
- Rodriguez Laura Lyman
- Romasko Edward J.
- Rosenthal Elisabeth A.
- Salama Joseph
- Salama Joseph S.
- Scarano Maria I.
- Schneider Jennifer
- Scollon Sarah
- Scollon Sarah
- Seidman Christine E.
- Seifert Bryce A.
- Sharp Richard R.
- Sharp Richard R.
- Shirts Brian
- Shirts Brian H.
- Sholl Lynette M.
- Siddiqui Javed
- Silverman Elian
- Simmons Shirley
- Simons Janae V.
- Skinner Debra
- Spinner Nancy B.
- Spinner Nancy B.
- Stoffel Elena
- Strande Natasha T.
- Sunyaev Shamil
- Sybert Virginia P.
- Taber Jennifer
- Tabor Holly K.
- Tabor Holly K.
- Tarczy-Hornoch Peter
- Tarczy-Hornoch Peter
- Taylor Deanne M.
- Tilley Christian R.
- Tomlinson Ashley
- Trinidad Susan
- Tsai Ellen
- Ubel Peter
- Van Allen Eliezer M.
- Vassy Jason L.
- Vats Pankaj
- Veenstra David L.
- Veenstra David L.
- Vetter Victoria L.
- Vries Raymond D.
- Wagle Nikhil
- Wagle Nikhil
- Walser Sarah A.
- Walsh Rebecca C.
- Weck Karen
- Weck Karen
- Werner-Lin Allison
- Whittle Jana
- Wilfond Ben
- Wilfond Benjamin S.
- Wilhelmsen Kirk
- Wilhelmsen Kirk C.
- Wolf Susan M.
- Wolf Susan M.
- Wynn Julia
- Wynn Julia
- Yang Yaping
- Young Carol
- Yu Joon-Ho
- Yu Joon-Ho
- Zikmund-Fisher Brian J.
- Publication venue
- Publication date
- 01/01/2016
- Field of study
Despite rapid technical progress and demonstrable effectiveness for some types of diagnosis and therapy, much remains to be learned about clinical genome and exome sequencing (CGES) and its role within the practice of medicine. The Clinical Sequencing Exploratory Research (CSER) consortium includes 18 extramural research projects, one National Human Genome Research Institute (NHGRI) intramural project, and a coordinating center funded by the NHGRI and National Cancer Institute. The consortium is exploring analytic and clinical validity and utility, as well as the ethical, legal, and social implications of sequencing via multidisciplinary approaches; it has thus far recruited 5,577 participants across a spectrum of symptomatic and healthy children and adults by utilizing both germline and cancer sequencing. The CSER consortium is analyzing data and creating publically available procedures and tools related to participant preferences and consent, variant classification, disclosure and management of primary and secondary findings, health outcomes, and integration with electronic health records. Future research directions will refine measures of clinical utility of CGES in both germline and somatic testing, evaluate the use of CGES for screening in healthy individuals, explore the penetrance of pathogenic variants through extensive phenotyping, reduce discordances in public databases of genes and variants, examine social and ethnic disparities in the provision of genomics services, explore regulatory issues, and estimate the value and downstream costs of sequencing. The CSER consortium has established a shared community of research sites by using diverse approaches to pursue the evidence-based development of best practices in genomic medicine
Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1
- Author
- Abecasis Gonçalo R.
- Absher Devin
- Adrienne Cupples L.
- Aherrahrou Zouhair
- Allayee Hooman
- Allione Alessandra
- Altshuler David
- Amin Najaf
- Anand Sonia S.
- Andersen Karl
- Anderson Jeffrey L.
- Angelica Merlini Pier
- Ardissino Diego
- Ardlie Kristin
- Assimes Themistocles L.
- Aulchenko Yurii S.
- Baas Annette F.
- Badger Stephen A.
- Balkau Beverley
- Ball Stephen G.
- Balmforth Anthony J.
- Bandinelli Stefania
- Barbalic Maja
- Barnes Timothy A.
- Barroso Inês
- Becker Diane M.
- Becker Lewis C.
- Beckmann Jacques S.
- Benediktsson Rafn
- Bengtsson Boström Kristina
- Bennett Amanda J.
- Berger Klaus
- Berglund Göran
- Bergman Richard N.
- Bingham Sheila A.
- Bis Joshua C.
- Blagieva Roza
- Blair Ross D.
- Blankenberg Stefan
- Blankensteijn Jan D.
- Bochud Murielle
- Boehm Bernhard O.
- Boehnke Michael
- Boerwinkle Eric
- Bonnycastle Lori L.
- Bots Michiel L.
- Bown Matthew J.
- Bradley Declan T.
- Bragi Walters G.
- Braund Peter S.
- Bravenboer Bert
- Brown Morris
- Bumpstead Suzannah
- Burnand Kevin
- Burton Paul R.
- Burtt Noël P.
- Buysschaert Ian
- Cambien Francois
- Campbell Harry
- Carlquist John F.
- Cauchi Stephane
- Caulfield Mark
- Chambers John C.
- Charpentier Guillaume
- Chen Li
- Child Anne H.
- Chines Peter S.
- Cichon Sven
- Clarke Robert
- Clough Rachel E.
- Cockerill Gillian
- Codd Veryan
- Coin Lachlan
- Connell John M.
- Cornelis Marilyn
- Couper David J.
- Crawford Gabe
- Crawford Gabriel J.
- Daly Mark J.
- Davies Robert W.
- de Faire Ulf
- de Graaf Jacqueline
- de Jong Paul E.
- Dedoussis George
- Dehghan Abbas
- Deloukas Panos
- Demissie Serkalem
- Devaney Joseph M.
- Di Gregorio Alessandra
- Diemert Patrick
- Dina Christian
- Do Ron
- Doering Angela
- Dominiczak Anna
- Doney Alex S. F.
- Dupuis Josée
- Döring Angela
- Dörr Marcus
- Edkins Sarah
- Eifert Sandra
- El Mokhtari Nour Eddine
- Elliott Amanda L.
- Elliott Katherine S.
- Elliott Katherine S.
- Elliott Paul
- Ellis Stephen G.
- Elosua Roberto
- Engert James C.
- Epstein Stephen E.
- Erdmann Jeanette
- Erdos Michael R.
- Eriksson Per
- Ernst Florian
- Eyheramendy Susana
- Farrall Martin
- Felix Stephan B.
- Ferreira Teresa
- Ferrucci Luigi
- Fischer Marcus
- Florez Jose C.
- Folkersen Lasse
- Folsom Aaron R.
- Forouhi Nita G.
- Fox Caroline S.
- Franco-Cereceda Anders
- Franklin Christopher S.
- Frayling Timothy M.
- Freimer Nelson B.
- Freyer Jennifer
- Frikke-Schmidt Ruth
- Froguel Philippe
- Futers Simon
- Galan Pilar
- Ganser Martha
- Gateva Vesela
- Gerry Hill B.
- Gieger Christian
- Gigante Bruna
- Girelli Domenico
- Gloyn Anna L.
- Goel Anuj
- Golledge Jonathan
- Goodall Alison H.
- Grallert Harald
- Grarup Niels
- Green Todd
- Gretarsdottir Solveig
- Griffin Simon
- Grobbee Diederick E.
- Groop Leif
- Groves Christopher J.
- Guarrera Simonetta
- Gudnason Vilmundur
- Guiducci Candace
- Gulcher Jeffrey R.
- Gut Ivo G.
- Gwilliam Rhian
- Gyllensten Ulf
- Hadjadj Samy
- Hadley David
- Hafez Hany
- Hall Alistair S.
- Halperin Eran
- Hammond Naomi
- Hamsten Anders
- Hansen Torben
- Harrison Seamus C.
- Hartikainen Anna-Liisa
- Hassanali Neelam
- Hattersley Andrew T.
- Hazen Stanley L.
- Heath Simon C.
- Hengstenberg Christian
- Hercberg Serge
- Herder Christian
- Hide Winston A.
- Hill Andrew A.
- Hitman Graham A.
- Hofman Albert
- Hofmann Oliver M.
- Holm Hilma
- Homuth Georg
- Horne Benjamin D.
- Hu Frank B.
- Hua Zhao Jing
- Hughes Anne E.
- Humphries Steve E.
- Hunt Sarah E.
- Hunter David J.
- Huth Cornelia
- Hveem Kristian
- Illig Thomas
- Iribarren Carlos
- Isomaa Bo
- Jackson Anne U.
- Jarvelin Marjo-Riitta
- Johnson Anne
- Johnson Paul R. V.
- Johnson Toby
- Jones Gregory T.
- Jousilahti Pekka
- Jørgensen Torben
- Kaiser Michael A.
- Kao Wen H. L.
- Kaplan Lee M.
- Kastelein John J. P.
- Kathiresan Sekar
- Khaw Kay-Tee
- Kiemeney Lambertus A.
- Klopp Norman
- Knowles Joshua W.
- Kolovou Genovefa
- Kong Augustine
- Kooner Jaspal S.
- Kraft Peter
- Kuusisto Johanna
- König Inke R.
- Laakso Markku
- Laaksonen Reijo
- Laan Maris
- Lakatta Edward G.
- Lambrechts Diether
- Langenberg Claudia
- Lauritzen Torsten
- Leander Karin
- Lettre Guillaume
- Lewis David R.
- Li Mingyao
- Lieb Wolfgang
- Lieverse Aloysius
- Lim Noha
- Lindgren Cecilia M.
- Lindholt Jes S.
- Loley Christina
- Loos Ruth J. F.
- Lorbeer Roberto
- Lotery Andrew J.
- Lourdes Sampietro M.
- Luan Jian'an
- Luben Robert N.
- Lucas Gavin
- Lyssenko Valeriya
- Mannucci Pier M.
- Maouche Seraya
- Mark Lathrop G.
- Marre Michel
- Marrugat Jaume
- Martinelli Nicola
- Matthiasson Stefan E.
- Matthijs Boekholdt S.
- Matullo Giuseppe
- McArdle Wendy L.
- McCarroll Steve A.
- McCarthy Mark I.
- McCulloch Laura J.
- McKeown Pascal P.
- McNoe Les A.
- McPherson Ruth
- Meigs James B.
- Meisinger Christa
- Meitinger Thomas
- Melander Olle
- Meneton Pierre
- Merriman Tony R.
- Midthjell Kristian
- Mohlke Karen L.
- Mooser Vincent
- Morgan Thomas
- Morken Mario A.
- Morris Andrew D.
- Morris Andrew P.
- Muhlestein Joseph B.
- Munroe Patricia B.
- Musunuru Kiran
- März Winfried
- Mühleisen Thomas W.
- Münzel Thomas
- Nahrstaedt Janja
- Naik Dilip K.
- Najjar Samer S.
- Narisu Narisu
- Navarro Pau
- Navis Gerjan
- Nelson Christopher P.
- Newhouse Stephen J.
- Newton-Cheh Christopher
- Nilsson Peter
- Norman Paul E.
- Numans Mattijs E.
- Nöthen Markus M.
- O'Donnell Christopher J.
- O'Reilly Paul F.
- Olivieri Oliviero
- Onland-Moret N. Charlotte
- Org Elin
- Orho-Melander Marju
- Ouwehand Willem H.
- Owen Katharine R.
- Palmen Jutta
- Palmer Colin N. A.
- Panico Salvatore
- Pankow James S.
- Papadakis Konstantinos
- Patel Riyaz S.
- Patterson Chris C.
- Payne Felicity
- Peden John F.
- Pedersen Oluf
- Peltonen Leena
- Perola Markus
- Perry John R. B.
- Peters Annette
- Petersen Ann-Kristin
- Peyvandi Flora
- Pfeufer Arne
- Platou Carl
- Polidoro Silvia
- Potter Simon
- Pouta Anneli
- Powell Janet T.
- Pramstaller Peter P.
- Preuss Michael
- Proença Christine
- Prokopenko Inga
- Qi Lu
- Qu Liming
- Quertermous Thomas
- Quyyumi Arshed A.
- Rader Daniel J.
- Rallidis Loukianos S.
- Rathmann Wolfgang
- Raychaudhuri Soumya
- Reffelmann Thorsten
- Refstrup Mette
- Reilly Muredach P.
- Rettig Rainer
- Ricceri Fulvio
- Rice Catherine
- Roberts Robert
- Robertson Neil R.
- Rocheleau Ghislain
- Roden Michael
- Romanazzi Valeria
- Rosendaal Frits R.
- Rubin Diana
- Rudan Igor
- Sacerdote Carlotta
- Salomaa Veikko
- Samani Nilesh J.
- Sampson Michael J.
- Sandhu Manjinder S.
- Sanna Serena
- Saxena Richa
- Sayers Robert D.
- Schadt Eric
- Scheet Paul
- Schillert Arne
- Schlessinger David
- Schreiber Stefan
- Schrezenmeir Jürgen
- Schunkert Heribert
- Schwartz Stephen M.
- Schäfer Arne
- Scott D Julian A.
- Scott Laura J.
- Scuteri Angelo
- Seedorf Udo
- Segrè Ayellet V.
- Shields Beverley M.
- Shrader Peter
- Sigurdsson Gunnar
- Sijbrands Eric
- Siscovick David S.
- Sivananthan Mohan
- Sivapalaratnam Suthesh
- Sladek Rob
- Smith Alberto
- Smith Andrew J.
- Smith Tamara B.
- Snieder Harold
- Snoep Jaapjan D.
- Sohrabi Soroush
- Song Kijoung
- Soranzo Nicole
- Sparsø Thomas
- Spector Tim D.
- Spertus John A.
- Stark Klaus
- Stefansson Kari
- Stein Lincoln D.
- Steinthorsdottir Valgerdur
- Stewart Alexandre F. R.
- Stirrups Kathy
- Stoll Monika
- Strachan David P.
- Strassburger Klaus
- Stringham Heather M.
- Subirana Isaac
- Sun Qi
- Susan Burnett Mary
- Swift Amy J.
- Sylvius Nicolas
- Syvänen Ann-Christine
- Tanaka Toshiko
- Teijink Joep A. W.
- Tennstedt Stephanie
- Teumer Alexander
- Thompson John R.
- Thompson Matthew M.
- Thomson Ian A.
- Thorand Barbara
- Thorgeirsson Gudmundur
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Tichet Jean
- Tobin Martin D.
- Tognoni Giovanni
- Tomaszewski Maciej
- Topless Ruth
- Tuomi Tiinamaija
- Tuomilehto Jaakko
- Tybjærg-Hansen Anne
- Uda Manuela
- Uiterwaal Cuno S.
- Uitterlinden Andre
- Uitterlinden Andre G.
- Valle Timo T.
- van Bockxmeer Frank M.
- van Dam Rob M.
- van der Harst Pim
- van der Schouw Yvonne T.
- van Duijn Cornelia M.
- van Gilst Wiek H.
- van Haeften Timon W.
- van Herpt Thijs
- van Hoek Mandy
- van Rij Andre
- van Rij Andre M.
- van Vliet-Ostaptchouk Jana V.
- Vasudevan Thodur M.
- Vicky Phillips L.
- Vineis Paolo
- Voight Benjamin F.
- Vollenweider Peter
- Völker Uwe
- Völzke Henry
- Waeber Gerard
- Wain Louise V.
- Walker Mark
- Wallace Chris
- Waltham Matthew
- Wareham Nicholas J.
- Watanabe Richard M.
- Waterworth Dawn M.
- Watkins Hugh
- Webster John
- Weedon Michael N.
- Welch Ryan P.
- Wells George A.
- Wichmann H-Erich
- Wijmenga Cisca
- Wild John B.
- Wild Philipp S.
- Willenborg Christina
- Willer Cristen J.
- William Rayner N.
- Williams Frances M.
- Wilson Tang W. H.
- Wilson James F.
- Witteman Jaqueline C. M.
- Wouter Jukema J.
- Wright Benjamin J.
- Wu Guanming
- Ye Shu
- Yu Grace
- Yuan Xin
- Zeggini Eleftheria
- Zelenika Diana
- Zeller Tanja
- Zhai Guangju
- Zhang Feng
- Ziegler Andreas
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2011
- Field of study
Abdominal aortic aneurysm (AAA) is a common cause of morbidity and mortality and has a significant heritability. We carried out a genome-wide association discovery study of 1866 patients with AAA and 5435 controls and replication of promising signals (lead SNP with a p value < 1 × 10-5) in 2871 additional cases and 32,687 controls and performed further follow-up in 1491 AAA and 11,060 controls. In the discovery study, nine loci demonstrated association with AAA (p < 1 × 10-5). In the replication sample, the lead SNP at one of these loci, rs1466535, located within intron 1 of low-density-lipoprotein receptor-related protein 1 (LRP1) demonstrated significant association (p = 0.0042). We confirmed the association of rs1466535 and AAA in our follow-up study (p = 0.035). In a combined analysis (6228 AAA and 49182 controls), rs1466535 had a consistent effect size and direction in all sample sets (combined p = 4.52 × 10-10, odds ratio 1.15 [1.10-1.21]). No associations were seen for either rs1466535 or the 12q13.3 locus in independent association studies of coronary artery disease, blood pressure, diabetes, or hyperlipidaemia, suggesting that this locus is specific to AAA. Gene-expression studies demonstrated a trend toward increased LRP1 expression for the rs1466535 CC genotype in arterial tissues; there was a significant (p = 0.029) 1.19-fold (1.04-1.36) increase in LRP1 expression in CC homozygotes compared to TT homozygotes in aortic adventitia. Functional studies demonstrated that rs1466535 might alter a SREBP-1 binding site and influence enhancer activity at the locus. In conclusion, this study has identified a biologically plausible genetic variant associated specifically with AAA, and we suggest that this variant has a possible functional role in LRP1 expression
The genetic architecture of the human cerebral cortex
- Author
- Adams Hieab H H
- Adams Hieab H H
- Agartz Ingrid
- Ahlijanian Michael
- Ahmad Shahzad
- Ainscough Susan
- Aisen Paul
- Albers Colleen S
- Albert Marilyn
- Alhusaini Saud
- Allard Joanne
- Almeida Marcio A A
- Alnæs Dag
- Alvim Marina K M
- Ames David
- Ames David
- Amin Najaf
- Amlien Inge K
- Amouyel Philippe
- Ances Beau
- Anderson Karen
- Anderson Tim J
- Andersson Micael
- Andreassen Ole A
- Andreassen Ole A
- Apostolova Liana
- Ard Tyler
- Arias-Vasquez Alejandro
- Armstrong Nicola J
- Armstrong Nicola J
- Arnedo Vanessa
- Arnold Steven E
- Artiges Eric
- Artiges Eric
- Ashley-Koch Allison
- Assaly Michele
- Assareh Amelia A
- Asthana Sanjay
- Atkins Joshua R
- Aydin Semiha
- Ayesa-Arriola Rosa
- Baca Marne
- Bachman David
- Banaschewski Tobias
- Barbot Alexis
- Barker Gareth
- Barone Paolo
- Bartha Rob
- Bartzokis George
- Bastin Mark E
- Bastin Mark E
- Bates Vernice
- Baune Bernhard T
- Becerra Mauricio
- Becker Andreas
- Becker James T
- Beckett Laurel
- Beckham Jean C
- Beiser Alexa S
- Belden Christine M
- Belger Aysenil
- Bell Karen L
- Berg Daniela
- Bergman Howard
- Bernard Manon
- Bernard Manon
- Bernick Charles
- Bernstein Matthew
- Beyer Frauke
- Bezivin-Frere Pauline
- Biondo Francesca
- Bis Joshua C
- Bis Joshua C
- Bishop Courtney
- Black Sandra
- Blangero John
- Blank Karen
- Bodge Courtney
- Bokde Arun
- Bonakdarpour Borna
- Boomsma Dorret I
- Borges-Neto Salvador
- Borowski Bret
- Borrie Michael
- Bralten Janita
- Brand Connie
- Brandabur Melanie
- Brandt Christine L
- Brewer James
- Brockington John
- Brodaty Henry
- Brodaty Henry
- Bromberg Uli
- Brooks David
- Brooks William M
- Brosch Jared R
- Brouwer Rachel M
- Brown Gregory G
- Bruehl Ruediger
- Brunner Han G
- Buckholtz Neil
- Buckner Randy L
- Budson Andrew E
- Buimer Elizabeth E L
- Buitelaar Jan K
- Burke Anna
- Burns Jeffrey M
- Bustillo Juan R
- Bülow Robin
- Bülow Robin
- Bürger Christian
- Bÿchel Christian
- Cabrera Yuliana
- Cahn Wiepke
- Cairns Murray J
- Cairns Nigel J
- Calhoun Vince
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- Knol Maria J
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- Sirrel Sherye A
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- Taylor Peggy
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- Teng Edmond
- Teodoro Liberty
- Tetrud James
- Teumer Alexander
- Teumer Alexander
- Thai Gaby
- Thal Leon
- Thalamuthu Anbupalam
- Thalamuthu Anbupalam
- Thomas Cathi-Ann
- Thomopoulos Sophia I
- Thompson Paul
- Thompson Paul M
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- Todd Gretchen
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- Tolosa Eduardo
- Tooney Paul A
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- Trollor Julian N
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- Uhlmann Anne
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- Umek Robert
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- Vaishnavi Sanjeev
- Vallerga Costanza Ludovica
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- van der Brug Marcel
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- van der Meer Dennis
- Van der Wee Nic J A
- van Donkelaar Marjolein M J
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- van Dyck Christopher H
- van Eijk Liza
- van Erp Theo G M
- van Haren Neeltje E M
- van Noort Betteke
- van Rooij Daan
- van Tol Marie-José
- Vanderswag Helen
- Varma Pradeep
- Veillette Suzanne
- Veldink Jan H
- Veltman Dick J
- Vemuri Prashanthi
- Venkov Heli
- Verhoef Ellen
- Vernooij Meike W
- Villena Teresa
- Villringer Arno
- Voyvodic James T
- Völker Uwe
- Völzke Henry
- Walter Henrik
- Walter Henrik
- Walter Sarah
- Walton Esther
- Wang Mingyuan
- Wang Yunpeng
- Ward Chad
- Wardlaw Joanna M
- Wardlaw Joanna M
- Weber Bernd
- Weinberger Daniel R
- Weiner Michael
- Weiner Michael W
- Weintraub Sandra
- Wen Wei
- Wen Wei
- Westlye Lars T
- Whelan Christopher D
- Whelan Robert
- Whelan Robert
- White Tonya
- Willeke Diana
- Williams Karen
- Williams Steve
- Wilson Renee
- Winkfield David
- Witbracht Megan
- Witt Stephanie H
- Witte A Veronica
- Wittfeld Katharina
- Wittfeld Katharina
- Wolf Christiane
- Wolfers Thomas
- Wolk David A
- Womack Kyle
- Wong Terence Z
- Woo Ellen
- Wright Margaret J
- Wright Margaret J
- Wu Chuang-Kuo
- Wu Jing Qin
- Wurster Isabel
- Xia Rui
- Yamamori Hidenaga
- Yanez Beatriz
- Yang Mia
- Yang Qiong
- Yang Qiong
- Yankey Jon
- Yasuda Clarissa L
- Yeh Randy
- Yesavage Jerome
- Zamrini Edward
- Zare Habil
- Zaremba Dario
- Zhang Zuo
- Zhou Juan
- Zhu Alyssa H
- Zimmerman Earl A
- Ziolkowski Jaimie
- Zsembik Leo C P
- Zwiers Marcel P
- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 01/01/2020
- Field of study
The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder
Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors
- Author
- Abdellaoui Abdel
- Abramova Liliya
- Adams Mark
- Adams Mark J.
- Adan Roger A. H.
- Adolfsson Rolf
- Adolfsson Rolf
- Adorjan Kristina
- Agartz Ingrid
- Agartz Ingrid
- Agerbo Esben
- Agerbo Esben
- Agerbo Esben
- Aguayo Samuel
- Ahuja Sunil
- Air Tracy M.
- Air Tracy M.
- Al Eissa Mariam
- Albani Diego
- Alda Martin
- Alda Martin
- Alfredsson Lars
- Alfredsson Lars
- Alfredsson Lars
- Alliey-Rodriguez Ney
- Als Thomas D.
- Andlauer Till F. M.
- Ando Tetsuya
- Andreassen Ole A.
- Andreassen Ole A.
- Andreassen Ole A.
- Anjorin Adebayo
- Anjorin Adebayo
- Antilla Verneri
- Antoniou Anastasia
- Appadurai Vivek
- Argyres Dean P.
- Arolt Volker
- Artigas Maria Soler
- Aschauer Harald
- Ashley-Koch Allison E.
- Aslan Mihaela
- Awasthi Swapnil
- Awasthi Swapnil
- Awasthi Swapnil
- Azevedo M. Helena
- Babadjanova Gulja
- Bacanu Silviu-Alin
- Backlund Lena
- Baek Ji Hyun
- Baker Jessica H.
- Ballas Zuhair
- Bass Nicholas
- Bass Nicholas
- Bau Claiton H. D.
- Bauer Michael
- Baune Bernhard T.
- Baune Bernhard T.
- Baune Bernhard T.
- Beckham Jean
- Beckham Jean
- Beckham Jean C.
- Beekman Aartjan T. F.
- Beins Eva C.
- Bellivier Frank
- Bellivier Frank
- Bencko Vladimir
- Bengesser Susanne
- Bergen Andrew W.
- Bergen Andrew W.
- Bergen Sarah E.
- Berger Klaus
- Berger Klaus
- Berrettini Wade H.
- Berrettini Wade H.
- Berrettini Wade H.
- Bhushan Sujata
- Biernacka Joanna M.
- Biernacka Joanna M.
- Bigdeli Tim B.
- Bigdeli Tim B.
- Bigdeli Tim B.
- Binder Elisabeth B.
- Binder Elisabeth B.
- Birgegård Andreas
- Birner Armin
- Blackwood Douglas H. R.
- Boden Joseph M.
- Boehm Ilka
- Boehnke Michael
- Boehnke Michael
- Bohus Martin
- Bohus Martin
- Boks Marco P.
- Boks Marco P.
- Boni Claudette
- Boomsma Dorret I.
- Bosch Rosa
- Bosch Rosa
- Boyko Edward
- Braff David L.
- Brandt Harry
- Brandt Harry
- Breeling James
- Breen Gerome
- Breen Gerome
- Breen Gerome
- Breen Gerome
- Brewer Jessica V.
- Brophy Mary T.
- Brum Murielle
- Brumpton Ben M.
- Brunkhorst-Kanaan Nathalie
- Bryant Richard
- Bryois Julien
- Bryois Julien
- Bryois Julien
- Budde Monika
- Budde Monika
- Buehren Katharina
- Bulik Cynthia M.
- Bulik Cynthia M.
- Burghardt Roland
- Buttenschøn Henriette N.
- Bybjerg-Grauholm Jonas
- Bybjerg-Grauholm Jonas
- Byerley William
- Byrne Enda M.
- Byrne Enda M.
- Bækvad-Hansen Marie
- Bækvad-Hansen Marie
- Bøen Erlend
- Børglum Anders D.
- Børglum Anders D.
- Børglum Anders D.
- Børte Sigrid
- Cahn Wiepke
- Cai Na
- Cairns Murray
- Campos Adrian I.
- Carlberg Laura
- Carr Vaughan J.
- Carter Bruce W.
- Casas Miguel
- Casas Miquel
- Cassina Matteo
- Castelao Enrique
- Castelao Enrique
- Catts Stanley
- Cervantes Pablo
- Cervilla Jorge A.
- Chang Kyong-Mi
- Chang Xiao
- Charney Alexander W.
- Chaumette Boris
- Chen Hsi-Chung
- Chen Wei J.
- Cho Kelly
- Cho Kelly
- Christensen Jane Hvarregaard
- Cichon Sven
- Cichon Sven
- Cichon Sven
- Cichon Sven
- Clarke Toni-Kim
- Clarke Toni-Kim
- Clementi Maurizio
- Cohen David
- Coleman Jonathan R. I.
- Coleman Jonathan R. I.
- Coleman Jonathan R. I.
- Coleman Jonathan R. I.
- Colodro-Conde Lucía
- Cone Roger D.
- Connor Todd
- Constans Joseph
- Coombes Brandon
- Coon Hilary
- Corvin Aiden
- Corvin Aiden
- Courtet Philippe
- Couvy-Duchesne Baptiste
- Craddock Nicholas
- Craddock Nicholas
- Craddock Nick
- Craig David
- Crawford Gregory E.
- Crawford Steven
- Crawford Steven
- Crivelli Silvia
- Crow Scott
- Crow Scott
- Crowley James J.
- Cruceanu Cristiana
- Cuellar-Barboza Alfredo
- Cunningham Julie
- Curtis David
- Czerski Piotr M.
- Dahmen Norbert
- Dale Anders M.
- Dalkner Nina
- Danner Unna N.
- Dannlowski Udo
- Dannlowski Udo
- David Friederike S.
- Davies Gail
- Davis Oliver S. P.
- de Geus E. J. C.
- de Zwaan Martina
- Dedoussis George
- Degenhardt Franziska
- Degenhardt Franziska
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- Zerwas Stephanie
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- Zhao Hongyu
- Zhou Hang
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- Zillich Lea
- Zipfel Stephan
- Zwart John-Anker
- Świątkowska Beata
- Świątkowska Beata
- Świątkowska Beata
- Publication venue
- Publication date
- 01/01/2021
- Field of study
Background Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. Methods We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors. Results Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged. Conclusions Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders.Peer reviewe
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.
- Author
- Abecasis Goncalo
- Abecasis Gonçalo R.
- Aben Katja K.
- Absher Devin
- Aherrahrou Zouhair
- Ahlqvist Emma
- Ahmadi Kourosh
- Ahmed Nabeel
- Alavere Helene
- Alibrandi Maria T S
- Allayee Hooman
- Almgren Peter
- Altshuler David
- Amin Najaf
- Anand Sonia S.
- Andersen Karl
- Anderson Jeffrey L.
- Ardissino Diego
- Ardlie Kristin
- Armitage Jane
- Arnold Alice M.
- Aspelund Thor
- Assimes Themistocles L.
- Assmann Gerd
- Atwood Larry D.
- Aulchenko Yurii S.
- Azhar Muhammad
- Balkau Beverley
- Ball Stephen G.
- Balmforth Anthony J.
- Barbalic Maja
- Barker Adam
- Barker David J P
- Barlassina Christina
- Barlera Simona
- Barnes Daniel
- Barnes Timothy A.
- Barrett Amy
- Barroso H
- Barroso Inês
- Bataille Veronique
- Becker Diane M.
- Becker Lewis C.
- Beckmann Jacques S.
- Beilby John P.
- Ben-Shlomo Yoav
- Benediktsson Rafn
- Bennett Amanda J.
- Berger Klaus
- Bergman Richard N.
- Bergmann Sven
- Bernd Sonja I.
- Berndt Sonja I
- Biebermann Heike
- Bis Joshua C.
- Blagieva Roza
- Blakemore Alexandra I F
- Blankenberg Stefan
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- Griffin Simon
- Groop Leif
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- Grundberg Elin
- Gräßler Jürgen
- Grönberg Henrik
- Gu Harvest
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- Guiducci Candace
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- Gustafsso Stefan
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- Gyllensten Ulf
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- Hammond Christopher J.
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- Hassanali Neelam
- Hattersley Andrew T.
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- Heinrich Joachim
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- Hide Winston A.
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- Hitman Graham A.
- Hoesel Volker
- Hofman Albert
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- Isomaa Bo
- Jackso Anne U.
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- Jukema J. Wouter
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- Kaakinen Marika
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- Kanoni Stavroula
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- Kaprio Jaakko
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- Kilpeläine Tuomas O.
- Kilpeläinen Tuomas O
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- Koskinen Seppo
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- Krude Heiko
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- Kyriakou Theodosios
- Kähönen Mika
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- Laakso Markku
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- Lyssenko Valeriya
- Macciardi Fabio
- MAGIC [Unknown]
- Makrilakis Konstantinos
- Mallick Nadeem
- Mangino Massimo
- Mannila Maria Nastase
- Manning Alisa K.
- Mannucci Pier M.
- Manunta Paolo
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- McCarroll Steve A.
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- O'Rahilly Steve
- Offer Alison
- Ohlsson Claes
- Ohrvik John
- Olivieri Oliviero
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- Parts Leopold
- Paré Guillaume
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- Purcell Shaun
- Qi Lu
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- Rybin Denis
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- Ríos Manuel Serrano
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- Sigurdsson Gunnar
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- Silander Kaisa
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- Sivananthan Mohan
- Sivapalaratnam Suthesh
- Sladek Rob
- Sleight Peter
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- Sovio Ulla
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- Wareham Nicholas J.
- Wareham Nick J.
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- Watkins Hugh
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- Weedon Michael N.
- Welch Ryan
- Wells George A.
- Weyan Robert J.
- Weyant Robert J
- Wheele Eleanor
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- Wichmann H. Erich
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- Wiklund Fredrik
- Wild Philipp S.
- Wild Sarah H.
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- Willemsen Gonneke
- Willenborg Christina
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- Wilson James F.
- Winkle Thomas W.
- Winkler Thomas W
- Witte Daniel R.
- Witteman Jacqueline
- Witteman Jacqueline C.
- Witteman Jaqueline C M
- Woo Andrew R.
- Wood Andrew R
- Workalemah Tsegaselassie
- Workalemahu Tsegaselassie
- Wright Alan F.
- Wright Benjamin J.
- Wu Guanming
- Xie Weijia
- Xu Jianfeng
- Yang Jian
- Yang Tsun Po
- Ye Shu
- Zabena Carina
- Zaidi Moazzam
- Zaman Khan Shah
- Zeggini Eleftheria
- Zeller Tanja
- Zethelius Björn
- Zgaga Lina
- Zhang Qunyuan
- Zhang Weihua
- Zhao Jing Hua
- Ziegler Andreas
- Zillikens M. Carola
- Zitting Paavo
- Zondervan Krina T.
- Öhrvik John
- Östenson Claes Göran
- Publication venue
- Diabetes
- Publication date
- 01/01/2011
- Field of study
OBJECTIVE: Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired β-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). Studies of the insulin processing pathway could provide new insights about T2D pathophysiology. RESEARCH DESIGN AND METHODS: We have conducted a meta-analysis of genome-wide association tests of ∼2.5 million genotyped or imputed single nucleotide polymorphisms (SNPs) and fasting proinsulin levels in 10,701 nondiabetic adults of European ancestry, with follow-up of 23 loci in up to 16,378 individuals, using additive genetic models adjusted for age, sex, fasting insulin, and study-specific covariates. RESULTS: Nine SNPs at eight loci were associated with proinsulin levels (P < 5 × 10(-8)). Two loci (LARP6 and SGSM2) have not been previously related to metabolic traits, one (MADD) has been associated with fasting glucose, one (PCSK1) has been implicated in obesity, and four (TCF7L2, SLC30A8, VPS13C/C2CD4A/B, and ARAP1, formerly CENTD2) increase T2D risk. The proinsulin-raising allele of ARAP1 was associated with a lower fasting glucose (P = 1.7 × 10(-4)), improved β-cell function (P = 1.1 × 10(-5)), and lower risk of T2D (odds ratio 0.88; P = 7.8 × 10(-6)). Notably, PCSK1 encodes the protein prohormone convertase 1/3, the first enzyme in the insulin processing pathway. A genotype score composed of the nine proinsulin-raising alleles was not associated with coronary disease in two large case-control datasets. CONCLUSIONS: We have identified nine genetic variants associated with fasting proinsulin. Our findings illuminate the biology underlying glucose homeostasis and T2D development in humans and argue against a direct role of proinsulin in coronary artery disease pathogenesis
New genetic loci link adipose and insulin biology to body fat distribution.
- Author
- Aalto Ville
- Aasarød Knut
- Abecasis Goncalo R
- Abecasis Gonçalo
- Absher Devin
- Adair Linda S
- Adam Martin
- Adeyemo Adebowale
- Ahlqvist Emma
- Ahmadi Kourosh R
- Ahola Aila
- Ainali Chrysanthi
- Akylbekova Ermeg
- Ala-Korpela Mika
- Alavere Helen
- Albagha Omar M E
- Albrecht Eva
- Alen Markku
- Alexander Myriam
- Alhenc-Gelas François
- Alizadeh Behrooz Z
- Allison Matthew A
- Alonso Nerea
- Altshuler David
- Ambite Jose Luis
- Amin Najaf
- Amouyel Philippe
- An Ping
- Anderson Carl A
- Anderson Denise
- Anderson Garnet
- Andrews Jeanette S
- Antonella Mulas
- Antti Jula
- Aragaki Aaron K
- Arking Dan E
- Arnold Alice
- Arnold Alice M
- Arora Pankaj
- Arscott Gillian M
- Artigas Maria Soler
- Arveiler Dominique
- Asiki Gershim
- Aspelund Thor
- Assimes Themistocles L
- Atalay Mustafa
- Atkinson Elizabeth J
- Aulchenko Yurii
- Avery Christy
- Bain Stephen C
- Bakker Stephan J L
- Balcells Susana
- Balkau Beverley
- Ballantyne Christie M
- Balmforth Anthony J
- Bandinelli Stefania
- Barbalic Maja
- Barrett Amy
- Barroso Ines
- Barroso Inês
- Basart Hanneke
- Basart Hanneke V
- Bataille Veronique
- Baumert Jens
- Beckmann Jacques S
- Beekman Marian
- Been Latonya F
- Beilby John
- Beilby John P
- Bell Jordana T
- Bellis Claire
- Bennett Amanda J
- Bennett Franklyn
- Berenson Gerald S
- Bergman Richard N
- Bergmann Sven
- Berndt Sonja I
- Berne Christian
- Bidulescu Aurelian
- Bielak Lawrence F
- Bierut Laura J
- Biffar Reiner
- Bis Joshua C
- Blackburn Hannah
- Blangero John
- Blankenberg Stefan S
- Blüher Matthias
- Boban Mladen
- Bochud Murielle
- Boehm Bernhard O
- Boehnke Michael
- Boerwinkle Eric
- Boezen H Marike
- Bolton Jennifer L
- Bolton Judith A Hoffman
- Bonnet Fabrice
- Bonnycastle Lori L
- Boomsma Dorret I
- Borecki Ingrid
- Boright Andrew P
- Borja Judith B
- Bornstein Stefan R
- Boston Jonathan
- Bots Michiel L
- Bouatia-Naji Nabila
- Bouchard Claude
- Bovet Pascal
- Boyd Heather A
- Bragg-Gresham Jennifer L
- Brambilla Paolo
- Brand Eva
- Brand Stefan-Martin
- Brandi Maria Luisa
- Braund Peter S
- Brennan Eoin P
- Brismar Kerstin
- Brody Jennifer
- Broekmans Frank J
- Broer Linda
- Brown Matthew A
- Brown Morris J
- Brown-Gentry Kristin
- Bruinenberg Marcel
- Buchkovich Martin L
- Buckley Brendan M
- Buil Alfonso
- Bull Shelley B
- Burgdorf Christof
- Buring Julie E
- Burnett Mary S
- Burnier Michel
- Burri Andrea
- Burton Paul R
- Bush William S
- Busonero Fabio
- Buxbaum Sarah G
- Buyske Steve
- Buzkova Petra
- Byrne Enda M
- Böger Carsten A
- Böhringer Stefan
- Böttcher Yvonne
- Cambien Francois
- Campbell Harry
- Campbell Susan
- Carba Delia B
- Carlson Chris
- Carlson Olga D
- Carty Cara
- Casas Juan P
- Caspersen Ida H
- Castano-Betancourt Martha
- Cauchi Stéphane
- Cauley Jane A
- Caulfield Mark
- Cavalieri Margherita
- Cazier Jean-Baptiste
- Center Jacqueline R
- Cesana Giancarlo
- Chakravarti Aravinda
- Chambers John
- Chandak Giriraj R
- Chang Hsing-Yi
- Chang Yen-Pei C
- Chanock Stephen J
- Charchar Fadi J
- Chasman Dan
- Chaturvedi Nish
- Chen Constance
- Chen Han
- Chen Ida
- Chen Jin
- Chen Ming-Huei
- Chen Wei
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- Cheng Iona
- Cheng Sulin
- Chines Peter S
- Cho Yoon Shin
- Choi Murim
- Chouraki Vincent
- Christiansen Claus
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- Cimponeriu Dan
- Ciullo Marina
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- Clarke Robert
- Claudi-Boehm Simone
- Coassin Stefan
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- Cooper Matthew N
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- Coresh Josef
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- Cucca Francesco
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- Curhan Gary
- d'Adamo Pio
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- Dailiana Zoe
- Danesh John
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- Dastani Zari
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- van Pelt L Joost
- van Schoor Natasja M
- Van Vliet-Ostaptchouk Jana V
- van Wingerden Sophie
- van Wingerden Sophie W
- Van Zuydam Natalie
- Vandenput Liesbeth
- Varga Tibor V
- Vartiainen Erkki
- Vasan Ramachandran S
- Vedantam Sailaja
- Veldre Gudrun
- Verlaan Dominique
- Vernon Smith Albert
- Veronesi Giovanni
- Verweij Niek
- Verwoert Germaine
- Verwoert Germaine C
- Viigimaa Margus
- Viikari Jorma
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- Virtamo Jarmo
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- Völker Uwe
- Völzke Henry
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- Wagenknecht Lynne E
- Waggott Daryl
- Wagner Peter J
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- Wainwright Nicholas
- Waite Lindsay L
- Walker Mark
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- Wang Jie Jin
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- Wang Xiaoling
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- Waterworth Dawn
- Watkins Hugh
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- Wells George A
- Wennauer Roman
- Westra Harm-Jan
- Wheeler Eleanor
- Wheeler Heather E
- Whincup Peter H
- Whitfield John B
- Wichmann H Erich
- Wichmann H-Erich
- Widen Elisabeth
- Wiggins Kerri L
- Wijmenga Cisca
- Wijnands-van Gent Colette J M
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- Wild Sarah H
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- Willemsen Gonneke
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- Willenborg Christina
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- Wilsgaard Tom
- Wilson James F
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- Wilson Sarah
- Wilson Scott G
- Winkler Thomas
- Witteman Jacqueline C
- Witteman Jacqueline C M
- Wojczynski Mary K
- Wolffenbuttel Bruce H R
- Wong Andrew
- Wong Tien Y
- Woo Jean
- Wood Andrew R
- Wood Andy
- Workalemahu Tsegaselassie
- Wright Alan F
- Wu Chunyuan
- Wu Joseph M W
- Wu Ying
- Würtz Peter
- Xiao Su-Mei
- Yajnik Chittaranjan S
- Yang Jian
- Yang Qiong
- Yang Tsun-Po
- Yao Jie
- Yengo Loïc
- Yerges-Armstrong Laura M
- Young Alicia
- Young Elizabeth H
- Young J H
- Young Lauren
- Yuan Xin
- Zaboli Ghazal
- Zalloua Pierre A
- Zarrabeitia María T
- Zelenika Diana
- Zemunik Tatijana
- Zerbini Gianpaolo
- Zgaga Lina
- Zhai Guangju
- Zhang Feng
- Zhang Qunyuan
- Zhang Weihua
- Zhao Jing Hua
- Zhao Wei
- Zheng Hou-Feng
- Zheng Wei
- Zhou Yanhua
- Zhu Haidong
- Zhu Kun
- Zhu Xiaofeng
- Zhuang Wei V
- Zhuang Wei Vivian
- Ziegler Andreas
- Zillikens M Carola
- Zimmermann Martina E
- Zitting Paavo
- Zondervan Krina T
- Zukowska-Szczechowska Ewa
- Zygmunt Marek
- Ärnlöv Johan
- Österholm Anne-May
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms
Search for new particles in events with energetic jets and large missing transverse momentum in proton-proton collisions at root s=13 TeV
- Author
- Aarrestad Thea Klaeboe
- Aarup Petersen Henriette
- Abbaneo Duccio
- Abbiendi Giovanni
- Abbrescia Marcello
- Abdullin Salavat
- Abercrombie Daniel
- Abreu A.
- Acharya Himal
- Acosta Darin
- Adam Wolfgang
- Adamidis K.
- Adams Eric
- Adams Mark Raymond
- Adams Todd
- Addesa Francesca Maria
- Adloff Catherine
- Adzic Petar
- Afanasiev Serguei
- Agapitos Antonis
- Agarwal Garvita
- Aggleton Robin
- Agram Jean-Laurent
- Aguilar-Benitez Manuel
- Ahmad Ashfaq
- Ahmad Muhammad
- Ahmed Asar
- Ahuja Sudha
- Aime` Chiara
- Aime‘ C.
- Akchurin Nural
- Akgun Bora
- Akpinar Alp
- Albergo Sebastiano
- Albert Andreas
- Albrecht Steffen
- Albrow Michael
- Alcaraz Maestre Juan
- Aldaya Martin Maria
- Aldá Júnior Walter Luiz
- Aleksandrov Aleksandar
- Alexander James
- Alhusseini Mohammad
- Alimena Juliette
- Alison John
- Almond John
- Alpana Km
- Alvarez Gonzalez Barbara
- Alverson George
- Alves Gallo Pereira Miguel
- Alves Gilvan
- Aly Reham
- Alyari Maral
- Amapane Nicola
- Ambrozas Marijus
- Amendola Chiara
- Amin Nick
- Amram Oz
- Amsler Claude
- An Sitong
- An Ying
- Anagnostou Georgios
- Andrea Jeremy
- Andreassi Guido
- Andreev Vladimir
- Andreev Yu.
- Andreev Yuri
- Andrejkovic Janik Walter
- Andrews Michael Benjamin
- Androsov Konstantin
- Anguiano J.
- Antchev Georgy
- Anthony David
- Antunovic Zeljko
- Apollinari Giorgio
- Apparu Dylan
- Appelt Eric
- Apresyan Artur
- Apyan Aram
- Araujo Mariana
- Arcaro Daniel
- Arcidiacono Roberta
- Arenton Michael Wayne
- Argiro Stefano
- Arneodo Michele
- Aruta Caterina
- Asavapibhop Burin
- Asawatangtrakuldee Chayanit
- Asenov Patrick
- Asghar Muhammad Irfan
- Asilar Ece
- Askew Andrew
- Asmuss Paul
- Atakisi Ismail Okan
- Attikis Alexandros
- Auffray Etiennette
- Aushev Tagir
- Auzinger Georg
- Avati Valentina
- Avery Paul
- Avila Carlos
- Awais Ali
- Awan Muhammad Imran Malik
- Ayala Edy
- Ayala Gabriel
- Azarkin Maksim
- Azhgirey Igor
- Aziz Tariq
- Azzi Patrizia
- Azzurri Paolo
- Baarmand Marc M
- Babaev Anton
- Bacchetta Nicola
- Bachiller Irene
- Bachtis Michail
- Backhaus Malte
- Baden A.
- Baden Drew
- Baechler Joachim
- Bagliesi Giuseppe
- Bahinipati Seema
- Baillon Paul
- Bainbridge Robert
- Bakas Georgios
- Bakhshiansohi Hamed
- Bakshi Amandeep Singh
- Baldenegro Barrera Cristian
- Ban Yong
- Band Reyer
- Bandyopadhyay Hirak
- Banerjee Sudeshna
- Banerjee Sunanda
- Bansal Sunil
- Barbagli Giuseppe
- Barberis Emanuela
- Bargassa Pedrame
- Baringer Philip
- Barnes Virgil E
- Barney David
- Baron Owen
- Barria Patrizia
- Barrio Luna Mar
- Barroso Ferreira Filho Mapse
- Bartek Rachel
- Bartosik Nazar
- Bartók Márton
- Bastos Diogo
- Battilana Carlo
- Baty Austin
- Bauer Gerry
- Bauerdick Lothar AT
- Baxter Samuel
- Bayatmakou M.
- Bayshev Igor
- Bean Alice
- Beauceron Stephanie
- Beaudette Florian
- Becerril Gonzalez Hugo
- Bechtel Janek
- Beghin Diego
- Behera Prafulla Kumar
- Behera Subash Chandra
- Behnke Olaf
- Bein Samuel
- Belforte Stefano
- Bell Ken W
- Bellan Riccardo
- Belloni Alberto
- Bellora Andrea
- Belyaev Alexander
- Belyaev Andrey
- Benaglia Andrea
- Benato Lisa
- Bencze Gyorgy
- Bendavid Joshua
- Benecke Anna
- Benelli Gabriele
- Benitez Jose F
- Benussi Luigi
- Berenguer Antequera Jorge
- Bergauer Thomas
- Berger Pirmin
- Beri Suman Bala
- Bermúdez Martínez Armando
- Bernardes Cesar Augusto
- Bernet Colin
- Berry Douglas
- Berryhill Jeffrey
- Bertacchi Valerio
- Besancon Marc
- Bestintzanos I.
- Bethani Agni
- Beyrouthy Taha
- Bhal Eshwen
- Bhardwaj Ashutosh
- Bharthuar Shudhashil
- Bharti Monika
- Bhat Pushpalatha C
- Bhatnagar Vipin
- Bhattacharya Rajarshi
- Bhattacharya Saptaparna
- Bhattacharya Satyaki
- Bhattacharya Soham
- Bhowmik Debabrata
- Bhowmik Sandeep
- Bhyun Ji Hwan
- Bi Ran
- Bialkowska Helena
- Bianchini Lorenzo
- Bianco Michele
- Bianco Stefano
- Biino Cristina
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- Bilin Bugra
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- Bisello Dario
- Black Kevin
- Blekman Freya
- Blinov Vladimir
- Bloch Daniel
- Bloch Philippe
- Bloom Kenneth
- Bluj Michal
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- Bocci Andrea
- Bodek Arie
- Boimska Bozena
- Boldrini Giacomo
- Boletti Alessio
- Bologna Simone
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- Bonacorsi Daniele
- Bonanomi Matteo
- Bonham Brandon
- Bonilla Johan
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- Bose Tulika
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- Bouhali Othmane
- Bourgatte Guillaume
- Bourilkov Dimitri
- Bozzo Marco
- Bragagnolo Alberto
- Braghieri Alessandro
- Brainerd Christopher
- Brandao Malbouisson Helena
- Brandt Stephanie
- Branson James G
- Breedon Richard
- Breeze Shane
- Brew Christopher
- Bright-thonney Samuel
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- Buchmuller Oliver
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- Bundock Aaron
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- Bunkowski Karol
- Buontempo Salvatore
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- Busson Philippe
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- Butz Erik
- Bychkova Oksana
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- Bärtschi P.
- Cabrera Andrés
- Cabrillo Iban Jose
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- Cakir Altan
- Calandri Alessandro
- Calderon De La Barca Sanchez Manuel
- Calderon Alicia
- Cali Ivan Amos
- Calligaris Luigi
- Calzaferri Simone
- Camen Camille
- Caminada Lea
- Campagnari Claudio
- Campana M.
- Campanini Renato
- Campbell Alan
- Camporesi Tiziano
- Candelise Vieri
- Canelli Maria Florencia
- Canepa Anadi
- Cankocak Kerem
- Capeans Garrido Maria
- Capiluppi Paolo
- Cappati Alessandra
- Caputo Claudio
- Caraway Bryan
- Cardini Andrea
- Cardwell Bryan
- Carle Aurélien
- Carlin Roberto
- Carnevali Francesco
- Carrera Jarrin Edgar
- Carrillo Montoya Camilo Andres
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- Cartiglia Nicolo
- Carvalho Antunes De Oliveira Alexandra
- Carvalho Wagner
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- Caspart René
- Cassese Antonio
- Castaldi Rino
- Castaneda Hernandez Alfredo
- Castilla-Valdez Heriberto
- Castro Andrea
- Cavallari Francesca
- Cavallo Francesca Romana
- Cavallo Nicola
- Cavanaugh Richard
- Ceard Ludivine
- Ceccarelli Rudy
- Cepaitis Vilius
- Cepeda Maria
- Cerati Giuseppe Benedetto
- Cerci Salim
- Cerminara Gianluca
- Cerrada Marcos
- Cerri Olmo
- Cetorelli Flavia
- Chabert Eric Christian
- Chahal Gurpreet Singh
- Chang Philip
- Chanon Nicolas
- Chao Yuan
- Chapon Emilien
- Charlot Claude
- Chatterjee Rajdeep Mohan
- Chatterjee Suman
- Chaudhary Geetanjali
- Chauhan Shubhanshu
- Chauhan Sushil
- Chawla Ridhi
- Checchia Paolo
- Chekhovsky Vladimir
- Chen Cheng
- Chen Guo-Ming
- Chen He-Sheng
- Chen Kai-Feng
- Chen Mingshui
- Chen Po-Hsun
- Chen Xuan
- Chen Yi
- Chen Yuan
- Chen Ziheng
- Chenarani Shirin
- Cheng Chun
- Cheng Tongguang
- Cheng Yangyang
- Cherepanov Vladimir
- Chernyavskaya Nadezda
- Chertok Maxwell
- Cheung H. W. K.
- Chhibra Simranjit Singh
- Chiarito Brandon
- Chinellato Jose
- Chistov Ruslan
- Chlebana Frank
- Cho Sungwoong
- Choi Junho
- Choi M.
- Choi Suyong
- Chou John Paul
- Choudhary Brajesh C
- Choudhury Somnath
- Christoforou K.
- Chudasama Ruchi
- Chwalek Thorsten
- Ciangottini Diego
- Ciocci Maria Agnese
- Cipriani Marco
- Citron Matthew
- Cittolin Sergio
- Ciulli Vitaliano
- Civinini Carlo
- Claes Daniel R
- Clare Robert
- Clement Emyr
- Clerbaux Barbara
- CMS Collaboration
- Cockerill David JA
- Colaleo Anna
- Coldham Kathryn
- Cole Joanne
- Colino Nicanor
- Collard Caroline
- Colling David
- Colombina F.
- Cometti Simona
- Connor Patrick
- Consuegra Rodríguez Sandra
- Contardo Didier
- Conway John
- Cooke Charlotte
- Cooper Seth
- Cooperstein Stephane
- Corcodilos Lucas
- Cormier Kyle
- Cornelis Tom
- Correia Silva Gilson
- Cosby Christopher
- Cossutti Fabio
- Costa Marco
- Costa Salvatore
- Coubez Xavier
- Couderc Fabrice
- Cousins Robert
- Covarelli Roberto
- Cox Bradley
- Cox Peter Timothy
- Cranshaw Derek James
- Creanza Donato
- Cremonesi Matteo
- Cristella Leonardo
- Csanad Mate
- Csorgo Tamas Ferenc
- Cuevas Javier
- Cuffiani Marco
- Cumalat John Perry
- Cummings Grace
- Cussans David
- Cutts David
- Czellar Sandor
- D'Alessandro Raffaello
- D'Alfonso Mariarosaria
- D'Amante Valeria
- D'Enterria David
- D'Hondt Jorgen
- Da Costa Eliza Melo
- Da Rold Alessandro
- Da Silveira Gustavo Gil
- Dabrowski Anne
- Dalchenko Mykhailo
- Dallavalle Gaetano-Marco
- Damarseckin Serdal
- Damgov Jordan
- Danilov Mikhail
- Danilov Vladyslav
- Darej Douja
- Darwish Mohamed Rashad
- Das Abhishek
- Das Pallabi
- Das Souvik
- Daskalakis Georgios
- Dasu Sridhara
- Datta Abhisek
- Dauncey Paul
- David Tinoco Mendes Andre
- David Pieter
- Davies Gavin
- Davignon Olivier
- Davis J.
- de Barbaro Pawel
- De Boer Wim
- De Bruyn Isabelle
- De Cosa Annapaola
- De Filippis Nicola
- De Guio Federico
- De Iorio Agostino
- De Jesus Damiao Dilson
- De La Cruz Begona
- De La Cruz-Burelo Eduard
- De Lentdecker Gilles
- De Leo Ksenia
- De Moraes Gregores Eduardo
- De Palma Mauro
- De Roeck Albert
- De Silva Malinda
- De Souza Lemos Dener
- de Trocóniz Jorge F
- De Wit Adinda
- De Wolf Eddi A
- Decaro Matthew
- Deelen Nikkie
- Defranchis Matteo Maria
- Deile Mario
- Dejardin Marc
- Del Burgo Riccardo
- Del Re Daniele
- Delaere Christophe
- Delannoy Andrés G
- Delcourt Martin
- Delgado Peris Antonio
- Delgado Andrea
- Dell'Orso Roberto
- Della Negra Michel
- Della Ricca Giuseppe
- Demaria Natale
- Demina Regina
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- Demiroglu Zuhal Seyma
- Denegri Daniel
- Depasse Pierre
- Dermenev Alexander
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- Dharmaratna Welathantri GD
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- Fallavollita Francesco
- Fallon Colin
- Falmagne Guillaume
- Faltermann Nils
- Fanfani Alessandra
- Fangmeier Caleb
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- Fasanella Daniele
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- Ferbel Thomas
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- Fernandez Bedoya Cristina
- Fernandez Madrazo Celia
- Fernandez Menendez Javier
- Fernandez Perez Tomei T. R.
- Fernandez Marcos
- Fernández Manteca Pedro José
- Fernández Ramos Juan Pablo
- Ferri Federico
- Ferro Fabrizio
- Field Richard D
- Fienga Francesco
- Filatov Oleg
- Finco Linda
- Finger Jr Michael
- Finger Miroslav
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- Flowers Z.
- Flügge Günter
- Focardi Ettore
- Folgueras Santiago
- Fonseca De Souza Sandro
- Fontaine Jean-Charles
- Fontanesi Elisa
- Ford William T
- Forthomme Laurent
- Foudas Costas
- Fouz Maria Cruz
- Fraga Jorge
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- Frankenthal Andre
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- Freed Sarah
- Freeman Jim
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- Fruehwirth Rudolf
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- Galanti Mario
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- Gandrakota Abhijith
- Ganjour Serguei
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- Garbers Christoph
- Garcia Fuentes Francisco Ignacio
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- García Alonso Andrea
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- Garutti Erika
- Gary J William
- Gascon Susan
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- Geurts Frank JM
- Ghezzi Alessio
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- Gill Karl
- Gilmore Jason
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- Givernaud Alain
- Glege Frank
- Glessgen Franz
- Gleyzer Sergei V
- Gninenko Sergei
- Go Yeonju
- Godinovic Nikola
- Goerlach Ulrich
- Goh Junghwan
- Gola Mohit
- Goldouzian Reza
- Goldstein Joel
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- Golovtcov Victor
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- Gomez Ceballos Guillelmo
- Gomez Gervasio
- Goncharov Maxim
- Gonzalez Caballero Isidro
- Gonzalez Lopez Oscar
- González Fernández Juan Rodrigo
- Gorbunov Ilya
- Gordon Michael
- Gosewisch Jan-ole
- Gottmann Artur
- Gouskos Loukas
- Gouzevitch Maxime
- Govoni Pietro
- Goy Lopez Silvia
- Grab Christoph
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- Granier de Cassagnac Raphael
- Gras Philippe
- Gray Lindsey
- Grebenyuk Anastasia
- Green Dan
- Greenberg Bennett
- Greene Senta
- Gribushin Andrey
- Grimault Clément
- Gritsan Andrei
- Grohsjean Alexander
- Grosso Gaia
- Grunewald Martin
- Grynyov Boris
- Grzanka Leszek
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- Guerrero Daniel
- Guiang Jonathan
- Guiducci Luigi
- Gul Muhammad
- Guler Yalcin
- Gunnellini Paolo
- Gunter Thoth
- Gupta Rajat
- Gurpinar Guler Emine
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- Gurtu Atul
- Gutay Laszlo
- Guthoff Moritz
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- Guzzi Luca
- Gómez Espinosa Tirso Alejandro
- Górski Maciej
- Gülmez Erhan
- Ha Seungkyu
- Habibullah Redwan
- Haddad Yacine
- Hadjiiska Roumyana
- Hadley Mary
- Hadley Nicholas John
- Hagopian Vasken
- Hahn Kristan Allan
- Haj Ahmad Wael
- Hajdu Csaba
- Hajheidari Mohammadtaghi
- Hakala John
- Hakimi Alexandre
- Halkiadakis Eva
- Hall Geoffrey
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- Hatakeyama Kenichi
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- Rauser Johann
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- Re Valerio
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- Xiang Yifan
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- Xiao Meng
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- Yalvac Metin
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- Yan Xuli
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- Yang Shuai
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- Yang Yu Chul
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- Ye Zhenyu
- Yetkin Elif Asli
- Yi Kai
- Yigitbasi Efe
- Yohay Rachel
- Yoo Hwi Dong
- Yoo Jaehyeok
- Yoon Inseok
- You Zhengyun
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- Yu Intae
- Yu Pei-rong
- Yu Shin-Shan
- Yuan Li
- Yuan Siqi
- Yuldashev Bekhzod S
- Yumiceva Francisco
- Yusli Mohd Nizam
- Zabi Alexandre
- Zacharopoulou Anna
- Zahid Sema
- Zaleski Shawn
- Zalewski Piotr
- Zanetti Marco
- Zarubin Anatoli
- Zarucki Mateusz
- Zecchinelli Angelo Giacomo
- Zeinali Maryam
- Zeuner Wolfram Dietrich
- Zghiche Amina
- Zhang Fengwangdong
- Zhang Huaqiao
- Zhang Jingyu
- Zhang Liuyao
- Zhang Wenyu
- Zhang Yi
- Zhang Yousen
- Zhang Zhicai
- Zhao Jingzhou
- Zhizhin Ilia
- Zhokin Alexander
- Zhu De Hua
- Zhu Ren-Yuan
- Ziemons Tim
- Zoi Irene
- Zolkapli Zukhaimira
- Zorbakir Ibrahim Soner
- Zorbilmez Caglar
- Zotto Pierluigi
- Zotz Alexander
- Zou David
- Zou Rui
- Zucchetta Alberto
- Zumerle Gianni
- Zuo Xunwu
- Zuolo Davide
- Zygala Lara
- Álvarez Fernández Adrian
- Özçelik Özlem
- Publication venue
- Publication date
- 01/01/2021
- Field of study
A search is presented for new particles produced at the LHC in proton-proton collisions at root s = 13 TeV, using events with energetic jets and large missing transverse momentum. The analysis is based on a data sample corresponding to an integrated luminosity of 101 fb(-1), collected in 2017-2018 with the CMS detector. Machine learning techniques are used to define separate categories for events with narrow jets from initial-state radiation and events with large-radius jets consistent with a hadronic decay of a W or Z boson. A statistical combination is made with an earlier search based on a data sample of 36 fb(-1), collected in 2016. No significant excess of events is observed with respect to the standard model background expectation determined from control samples in data. The results are interpreted in terms of limits on the branching fraction of an invisible decay of the Higgs boson, as well as constraints on simplified models of dark matter, on first-generation scalar leptoquarks decaying to quarks and neutrinos, and on models with large extra dimensions. Several of the new limits, specifically for spin-1 dark matter mediators, pseudoscalar mediators, colored mediators, and leptoquarks, are the most restrictive to date.Peer reviewe
Combined searches for the production of supersymmetric top quark partners in proton-proton collisions at root s=13 TeV
- Author
- Aarrestad Thea Klaeboe
- Aarup Petersen Henriette
- Abbaneo Duccio
- Abbiendi Giovanni
- Abbrescia Marcello
- Abdalla Hassan
- Abdullin Salavat
- Abercrombie Daniel
- Abreu A.
- Acharya Himal
- Acosta Darin
- Adam Wolfgang
- Adamov George
- Adams Eric
- Adams Mark Raymond
- Adams Todd
- Addesa Francesca Maria
- Adloff Catherine
- Adzic Petar
- Afanasiev Serguei
- Agapitos Antonis
- Agarwal Garvita
- Aggleton Robin
- Agram Jean-Laurent
- Aguilar-Benitez Manuel
- Ahmad Ashfaq
- Ahmad Muhammad
- Ahmed Asar
- Ahuja Sudha
- Aime` Chiara
- Aime‘ C.
- Akchurin Nural
- Akgun Bora
- Akpinar Alp
- Albergo Sebastiano
- Albert Andreas
- Albrecht Steffen
- Albrow Michael
- Alcaraz Maestre Juan
- Aldaya Martin Maria
- Aldá Júnior Walter Luiz
- Aleksandrov Aleksandar
- Alexander James
- Alhusseini Mohammad
- Alimena Juliette
- Alison John
- Almond John
- Alpana Km
- Alvarez Gonzalez Barbara
- Alverson George
- Alves Gallo Pereira Miguel
- Alves Gilvan
- Aly Reham
- Alyari Maral
- Amapane Nicola
- Ambrozas Marijus
- Amendola Chiara
- Amin Nick
- Amram Oz
- Amsler Claude
- An Sitong
- An Ying
- Anagnostou Georgios
- Andrea Jeremy
- Andreassi Guido
- Andreev Vladimir
- Andreev Yu.
- Andreev Yuri
- Andrejkovic Janik Walter
- Andrews Michael Benjamin
- Androsov Konstantin
- Anguiano J.
- Antchev Georgy
- Anthony David
- Antunovic Zeljko
- Apollinari Giorgio
- Apparu Dylan
- Appelt Eric
- Apresyan Artur
- Apyan Aram
- Araujo Mariana
- Arcaro Daniel
- Arcidiacono Roberta
- Arenton Michael Wayne
- Argiro Stefano
- Arneodo Michele
- Aruta Caterina
- Asavapibhop Burin
- Asawatangtrakuldee Chayanit
- Asenov Patrick
- Asghar Muhammad Irfan
- Asilar Ece
- Askew Andrew
- Asmuss Paul
- Atakisi Ismail Okan
- Attikis Alexandros
- Auffray Etiennette
- Aushev Tagir
- Auzinger Georg
- Avati Valentina
- Avery Paul
- Avila Carlos
- Awais Ali
- Awan Muhammad Imran Malik
- Ayala Edy
- Ayala Gabriel
- Azarkin Maksim
- Azhgirey Igor
- Aziz Tariq
- Azzi Patrizia
- Azzurri Paolo
- Baarmand Marc M.
- Babaev Anton
- Babounikau Illia
- Bacchetta Nicola
- Bachiller Irene
- Bachtis Michail
- Backhaus Malte
- Baden A.
- Baden Drew
- Baechler Joachim
- Bagliesi Giuseppe
- Bahinipati Seema
- Baillon Paul
- Bainbridge Robert
- Bakas Georgios
- Bakhshiansohi Hamed
- Bakshi Amandeep Singh
- Baldenegro Barrera Cristian
- Ban Yong
- Band Reyer
- Bandyopadhyay Hirak
- Banerjee Sudeshna
- Banerjee Sunanda
- Bansal Sunil
- Barbagli Giuseppe
- Barberis Emanuela
- Bargassa Pedrame
- Baringer Philip
- Barnes Virgil E.
- Barney David
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- Bartosik Nazar
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- Baty Austin
- Bauer Gerry
- Bauerdick Lothar A. T.
- Baxter Samuel
- Bayshev Igor
- Bean Alice
- Beauceron Stephanie
- Beaudette Florian
- Becerril Gonzalez Hugo
- Bechtel Janek
- Beghin Diego
- Behera Prafulla Kumar
- Behera Subash Chandra
- Behnke Olaf
- Bein Samuel
- Belforte Stefano
- Bell Ken W.
- Bellan Riccardo
- Belloni Alberto
- Bellora Andrea
- Belyaev Alexander
- Belyaev Andrey
- Benaglia Andrea
- Benato Lisa
- Bencze Gyorgy
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- Benitez Jose F.
- Benussi Luigi
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- Bergauer Thomas
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- Berger Thomas
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- Bermúdez Martínez Armando
- Bernardes Cesar Augusto
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- Bhardwaj Ashutosh
- Bharthuar Shudhashil
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- Bhat Pushpalatha C.
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- Bilin Bugra
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- Chabert Eric Christian
- Chahal Gurpreet Singh
- Chang Philip
- Chanon Nicolas
- Chao Yuan
- Chapon Emilien
- Charlot Claude
- Chatterjee Rajdeep Mohan
- Chatterjee Suman
- Chaudhary Geetanjali
- Chauhan Shubhanshu
- Chauhan Sushil
- Chawla Ridhi
- Checchia Paolo
- Chekhovsky Vladimir
- Chen Cheng
- Chen Guo-Ming
- Chen He-Sheng
- Chen Kai-Feng
- Chen Mingshui
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- Chen Xuan
- Chen Yi
- Chen Yuan
- Chen Ziheng
- Chenarani Shirin
- Cheng Chun
- Cheng Tongguang
- Cheng Yangyang
- Cherepanov Vladimir
- Chernyavskaya Nadezda
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- Cheung H. W. K.
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- Chiarito Brandon
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- Chlebana Frank
- Cho Sungwoong
- Choi Junho
- Choi M.
- Choi Suyong
- Chou John Paul
- Choudhary Brajesh C.
- Christoforou K.
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- Citron Matthew
- Cittolin Sergio
- Ciulli Vitaliano
- Civinini Carlo
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- Clare Robert
- Clement Emyr
- Clerbaux Barbara
- CMS Collaboration
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- Colaleo Anna
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- Cooperstein Stephane
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- Creanza Donato
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- Csanad Mate
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- Cuffiani Marco
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- Cummings Grace
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- D'Alfonso Mariarosaria
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- D'Enterria David
- D'Hondt Jorgen
- Da Costa Eliza Melo
- Da Rold Alessandro
- Da Silveira Gustavo Gil
- Dabrowski Anne
- Daci Nadir
- Dalchenko Mykhailo
- Dallavalle Gaetano-Marco
- Damarseckin Serdal
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- Danilov Mikhail
- Danilov Vladyslav
- Darej Douja
- Darwish Mohamed Rashad
- Das Abhishek
- Das Pallabi
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- Daskalakis Georgios
- Dasu Sridhara
- Datta Abhisek
- Dauncey Paul
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- Davignon Olivier
- Davis J.
- de Barbaro Pawel
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- De Clercq Jarne
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- De Filippis Nicola
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- Decaro Matthew
- Deelen Nikkie
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- Wang Quan
- Wang Qun
- Wang Sicheng
- Wang Xiao
- Wang Yi
- Wang Zhangqier
- Wang Zhixing
- Waqas Muhammad
- Wardle Nicholas
- Warner Z.
- Wassmer Michael
- Watson I. J.
- Wayne Mitchell
- Webb Samuel Nathan
- Weber Hannsjoerg Artur
- Weber Marc
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- Wen Yiwen
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- West Christopher
- Wezenbeek Liam
- Whitbeck Andrew
- White Robert
- White Sebastian
- Wichmann Katarzyna
- Wickramage Nadeesha
- Wickramarathna D. D. C.
- Wiedenbeck Sebastian
- Wieland Sebastian
- Wiens Lucas
- Wightman Andrew
- Williams Ac
- Williams Justin
- Williams Thomas
- Willmott Carlos
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- Wilson Jonathan
- Wimpenny Stephen
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- Winterbottom Daniel
- Wisecarver Andrew
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- Wolf Roger
- Wolfe Evan
- Wong Kak
- Wong Wing Yan
- Wood Darien
- Wozniak Kinga Anna
- Wozniewski Sebastian
- Wright Douglas
- Wu Hsin-yeh
- Wu Zhenbin
- Wuchterl Sebastian
- Wulz Claudia-Elisabeth
- Wunsch Stefan
- Wyslouch Bolek
- Würthwein Frank
- Xiang Yifan
- Xiao Jie
- Xiao Meng
- Xiao Rui
- Xie Si
- Xie Wei
- Yagil Avraham
- Yalvac Metin
- Yan Furong
- Yan Xuli
- Yang S.
- Yang Shuai
- Yang Unki
- Yang Yu Chul
- Yao Yao
- Yarar Hevjin
- Yates Brent
- Yazgan Efe
- Ye Zhenyu
- Yetkin Elif Asli
- Yi Kai
- Yigitbasi Efe
- Yohay Rachel
- Yoo Hwi Dong
- Yoo Jaehyeok
- Yoon Inseok
- You Zhengyun
- Yu David
- Yu Geum Bong
- Yu Intae
- Yu Pei-rong
- Yu Shin-Shan
- Yuan Li
- Yuan Siqi
- Yuldashev Bekhzod S.
- Yumiceva Francisco
- Yusli Mohd Nizam
- Zabi Alexandre
- Zacharopoulou Anna
- Zahid Sema
- Zaleski Shawn
- Zalewski Piotr
- Zanetti Marco
- Zarubin Anatoli
- Zarucki Mateusz
- Zecchinelli Angelo Giacomo
- Zeinali Maryam
- Zeuner Wolfram Dietrich
- Zghiche Amina
- Zhang Fengwangdong
- Zhang Huaqiao
- Zhang Jingyu
- Zhang Liuyao
- Zhang Sijing
- Zhang Wenyu
- Zhang Yi
- Zhang Yousen
- Zhang Zhicai
- Zhao Jingzhou
- Zhizhin Ilia
- Zhokin Alexander
- Zhu De Hua
- Zhu Ren-Yuan
- Ziemons Tim Matthias
- Zoi Irene
- Zolkapli Zukhaimira
- Zorbakir Ibrahim Soner
- Zorbilmez Caglar
- Zotto Pierluigi
- Zou David
- Zou Rui
- Zucchetta Alberto
- Zumerle Gianni
- Zuo Xunwu
- Zuolo Davide
- Zygala Lara
- Álvarez Fernández Adrian
- Özçelik Özlem
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2020
- Field of study
A combination of searches for top squark pair production using proton-proton collision data at a center-of-mass energy of 13 TeV at the CERN LHC, corresponding to an integrated luminosity of 137 fb(-1) collected by the CMS experiment, is presented. Signatures with at least 2 jets and large missing transverse momentum are categorized into events with 0, 1, or 2 leptons. New results for regions of parameter space where the kinematical properties of top squark pair production and top quark pair production are very similar are presented. Depending on themodel, the combined result excludes a top squarkmass up to 1325 GeV for amassless neutralino, and a neutralinomass up to 700 GeV for a top squarkmass of 1150 GeV. Top squarks with masses from 145 to 295 GeV, for neutralino masses from 0 to 100 GeV, with a mass difference between the top squark and the neutralino in a window of 30 GeV around the mass of the top quark, are excluded for the first time with CMS data. The results of theses searches are also interpreted in an alternative signal model of dark matter production via a spin-0 mediator in association with a top quark pair. Upper limits are set on the cross section for mediator particle masses of up to 420 GeV
Probing effective field theory operators in the associated production of top quarks with a Z boson in multilepton final states at root s=13 TeV
- Author
- Aarrestad Thea Klaeboe
- Aarup Petersen Henriette
- Abbaneo Duccio
- Abbiendi Giovanni
- Abbrescia Marcello
- Abdalla Hassan
- Abdullin Salavat
- Abercrombie Daniel
- Abreu A.
- Acharya Himal
- Acosta Darin
- Adam Wolfgang
- Adamidis K.
- Adamov George
- Adams Eric
- Adams Mark Raymond
- Adams Todd
- Addesa Francesca Maria
- Adloff Catherine
- Adzic Petar
- Afanasiev Serguei
- Agapitos Antonis
- Agarwal Garvita
- Aggleton Robin
- Agram Jean-Laurent
- Aguilar-Benitez Manuel
- Ahmad Ashfaq
- Ahmad Muhammad
- Ahmed Asar
- Ahuja Sudha
- Aime` Chiara
- Aime‘ C.
- Akchurin Nural
- Akgun Bora
- Akpinar Alp
- Albergo Sebastiano
- Albert Andreas
- Albrecht Steffen
- Albrow Michael
- Alcaraz Maestre Juan
- Aldaya Martin Maria
- Aldá Júnior Walter Luiz
- Aleksandrov Aleksandar
- Alexander James
- Alhusseini Mohammad
- Alimena Juliette
- Alison John
- Almond John
- Alpana Km
- Alvarez Gonzalez Barbara
- Alverson George
- Alves Gallo Pereira Miguel
- Alves Gilvan
- Aly Reham
- Alyari Maral
- Amapane Nicola
- Ambrozas Marijus
- Amendola Chiara
- Amin Nick
- Amram Oz
- Amsler Claude
- An Sitong
- An Ying
- Anagnostou Georgios
- Andrea Jeremy
- Andreassi Guido
- Andreev Vladimir
- Andreev Yu.
- Andreev Yuri
- Andrejkovic Janik Walter
- Andrews Michael Benjamin
- Androsov Konstantin
- Anguiano J.
- Antchev Georgy
- Anthony David
- Antunovic Zeljko
- Apollinari Giorgio
- Apparu Dylan
- Appelt Eric
- Apresyan Artur
- Apyan Aram
- Araujo Mariana
- Arcaro Daniel
- Arcidiacono Roberta
- Arenton Michael Wayne
- Argiro Stefano
- Arneodo Michele
- Aruta Caterina
- Asavapibhop Burin
- Asawatangtrakuldee Chayanit
- Asenov Patrick
- Asghar Muhammad Irfan
- Asilar Ece
- Askew Andrew
- Asmuss Paul
- Assran Yasser
- Atakisi Ismail Okan
- Attikis Alexandros
- Auffray Etiennette
- Aushev Tagir
- Auzinger Georg
- Avati Valentina
- Avery Paul
- Avila Carlos
- Awais Ali
- Awan Muhammad Imran Malik
- Ayala Edy
- Ayala Gabriel
- Azarkin Maksim
- Azhgirey Igor
- Aziz Tariq
- Azzi Patrizia
- Azzurri Paolo
- Baarmand Marc M
- Babaev Anton
- Bacchetta Nicola
- Bachiller Irene
- Bachtis Michail
- Backhaus Malte
- Baden A.
- Baden Drew
- Baechler Joachim
- Bagliesi Giuseppe
- Bahinipati Seema
- Baillon Paul
- Bainbridge Robert
- Bakas Georgios
- Bakhshiansohi Hamed
- Bakshi Amandeep Singh
- Baldenegro Barrera Cristian
- Ban Yong
- Band Reyer
- Bandyopadhyay Hirak
- Banerjee Sudeshna
- Banerjee Sunanda
- Bansal Sunil
- Barbagli Giuseppe
- Barberis Emanuela
- Bargassa Pedrame
- Baringer Philip
- Barnes Virgil E
- Barney David
- Baron Owen
- Barria Patrizia
- Barrio Luna Mar
- Barroso Ferreira Filho Mapse
- Bartek Rachel
- Bartosik Nazar
- Bartók Márton
- Bastos Diogo
- Battilana Carlo
- Baty Austin
- Bauer Gerry
- Bauerdick Lothar AT
- Baxter Samuel
- Bayatmakou M.
- Bayshev Igor
- Bean Alice
- Beauceron Stephanie
- Beaudette Florian
- Becerril Gonzalez Hugo
- Bechtel Janek
- Beghin Diego
- Behera Prafulla Kumar
- Behera Subash Chandra
- Behnke Olaf
- Bein Samuel
- Belforte Stefano
- Bell Ken W
- Bellan Riccardo
- Belloni Alberto
- Bellora Andrea
- Belyaev Alexander
- Belyaev Andrey
- Benaglia Andrea
- Benato Lisa
- Bencze Gyorgy
- Bendavid Joshua
- Benecke Anna
- Benelli Gabriele
- Benitez Jose F
- Benussi Luigi
- Berenguer Antequera Jorge
- Bergauer Thomas
- Berger Pirmin
- Beri Suman Bala
- Bermúdez Martínez Armando
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- Wightman Andrew
- Williams Ac
- Williams Justin
- Williams Thomas
- Willmott Carlos
- Wilson Graham
- Wilson Jonathan
- Wimpenny Stephen
- Winer Brian L
- Winterbottom Daniel
- Wisecarver Andrew
- Wissing Christoph
- Wittich Peter
- Wolf Roger
- Wolfe Evan
- Wong Kak
- Wong Wing Yan
- Wood Darien
- Wozniak Kinga Anna
- Wozniewski Sebastian
- Wright Douglas
- Wu Hsin-yeh
- Wu Zhenbin
- Wuchterl Sebastian
- Wulz Claudia-Elisabeth
- Wunsch Stefan
- Wyslouch Bolek
- Würthwein Frank
- Xiang Yifan
- Xiao Jie
- Xiao Meng
- Xiao Rui
- Xie Si
- Xie Wei
- Yagil Avraham
- Yalvac Metin
- Yan Furong
- Yan Xuli
- Yang S.
- Yang Shuai
- Yang Unki
- Yang Yu Chul
- Yao Yao
- Yarar Hevjin
- Yates Brent
- Yazgan Efe
- Ye Zhenyu
- Yetkin Elif Asli
- Yi Kai
- Yigitbasi Efe
- Yohay Rachel
- Yoo Hwi Dong
- Yoo Jaehyeok
- Yoon Inseok
- You Zhengyun
- Yu David
- Yu Geum Bong
- Yu Intae
- Yu Pei-rong
- Yu Shin-Shan
- Yuan Li
- Yuan Siqi
- Yuldashev Bekhzod S
- Yumiceva Francisco
- Yusli Mohd Nizam
- Zabi Alexandre
- Zacharopoulou Anna
- Zahid Sema
- Zaleski Shawn
- Zalewski Piotr
- Zanetti Marco
- Zarubin Anatoli
- Zarucki Mateusz
- Zecchinelli Angelo Giacomo
- Zeinali Maryam
- Zeuner Wolfram Dietrich
- Zghiche Amina
- Zhang Fengwangdong
- Zhang Huaqiao
- Zhang Jingyu
- Zhang Liuyao
- Zhang Wenyu
- Zhang Yi
- Zhang Yousen
- Zhang Zhicai
- Zhao Jingzhou
- Zhizhin Ilia
- Zhokin Alexander
- Zhu De Hua
- Zhu Ren-Yuan
- Ziemons Tim
- Zoi Irene
- Zolkapli Zukhaimira
- Zorbakir Ibrahim Soner
- Zorbilmez Caglar
- Zotto Pierluigi
- Zotz Alexander
- Zou David
- Zou Rui
- Zucchetta Alberto
- Zumerle Gianni
- Zuo Xunwu
- Zuolo Davide
- Zygala Lara
- Álvarez Fernández Adrian
- Özçelik Özlem
- Publication venue
- Publication date
- 01/01/2021
- Field of study
Peer reviewe
- …