Manejo de defectos del desarrollo del esmalte y secuelas en paciente con síndrome de Muenke

Los defectos del desarrollo de esmalte son alteraciones clínicamente visibles se pueden vincular a factores ambientales y genéticos, la prevalencia es de 70% y aumenta hasta un 83% si los pacientes tienen algún compromiso sistémico. El síndrome de Muenke es una craneosinostosis que tiene una incidencia de 1 en 30,000 nacidos vivos, representando el 24% de casos de craneosinostosis, este síndrome afecta comúnmente a la sutura coronal, el paciente presenta retraso del desarrollo, pérdida auditiva neurosensorial y la anomalía craneofacial más común es la maloclusión clase III y la hipoplasia del tercio medio. Describe el manejo de secuelas de los defectos del desarrollo del esmalte en sala de operaciones con un procedimiento odontológico integral en dientes primarios en una sola sesión. Presenta el caso de un paciente de 2 años 2 meses de edad sexo masculino con diagnóstico médico: síndrome de Muenke y sangrado nasal, diagnostico odontológico: fracturas post eruptivas del defecto del esmalte extensión I y II en las piezas 73, 72, 71, 81, 82, 83, y fracturas post eruptivas del defecto del esmalte extensión III de las piezas 62, 52, los tratamientos realizados fueron carillas de resina que permitieron restaurar las fracturas post eruptivas del defecto del esmalte extensión I y II de las piezas 73, 72, 71, 81, 82, 83. Pulpectomía en las piezas 62, 52 más coronas de resina a mano alzada fueron necesarias en las fracturas post eruptivas del defecto del esmalte extensión III. Se aplico barniz fluorado en la zona lingual de las piezas rehabilitadas con carillas. La evolución del paciente fue favorable. Concluye que se realizaron diferentes tratamientos odontológicos en nuestro paciente que presento secuelas de los defectos del desarrollo del esmalte, los tratamientos se consideran clínicamente exitosos ya que después de seis meses las piezas dentarias tratadas no presentaron dolor espontáneo, tampoco se observó fistulas o absceso, ni movilidad dentaria

Impuesto temporal a los activos netos y su incidencia en el impuesto a la renta en las empresas comerciales distribuidoras de materiales de construcción en el distrito de Comas 2020

El presente trabajo de investigación se tiene como objetivo Determinar de qué manera el Impuesto temporal a los activos netos incide en el impuesto a la renta en las empresas comerciales distribuidoras de materiales de construcción en el distrito de comas año 2020. La finalidad de este trabajo es dar a conocer a los contribuyentes la doble tributación que existe con respecto al pago del impuesto a la renta sobre todo a las empresas que están afectas al impuesto temporal a los activos netos que hayan obtenido perdidas económicas en 2020. La investigación se trabajó con la teoría de Moreno y Taboada que mediante su tesis para la obtención de la titulación donde se analiza el impuesto temporal a los activos netos y el impuesto a la renta, donde define que el pago por Impuesto Temporal a los Activos Netos afecta la capacidad contributiva de las empresas con pérdidas, desde el punto de vista económico. El tipo de investigación es no experimental, el diseño de la investigación es transversal con nivel descriptivo, con una población de 33 personas del área contable de las empresas comerciales distribuidoras de materiales de construcción, la muestra está compuesta por 30 personas del área contable. La técnica que se utilizo es la encuesta y el instrumento de recolección de datos, el cuestionario fue aplicado a las empresas distribuidoras de materiales de construcción. Para la validez de los instrumentos se utilizó el criterio de juicios de expertos y además está respaldado por el uso del Alfa de Cronbach; la comprobación de la hipótesis se realizó con la prueba Rho de Spearman. En la presente investigación se llegó a la conclusión que el impuesto temporal a los activos netos tiene incidencia con el impuesto a la renta de las empresas comerciales distribuidoras de materiales de construcción en el distrito de comas año 2020

Electrosynthesis of 2,3-butanediol and methyl ethyl ketone from acetoin in flow cells

Acetoin could shortly become a platform molecule due to current progress in fermentation technology, the megatrend for shifting from an oil-based economy to one based on biomass, the quest for green manufacturing processes and its two highly reactive carbonyl and hydroxyl moieties. In this paper, the successful electro-conversion of acetoin into two valuable chemicals, 2,3-butandiol (2,3-BD) and methyl ethyl ketone (MEK), at constant electrical current in aqueous phase at room temperature using both divided and undivided 20 cm2 filter-press flow cells under experimental conditions suitable for industrial production is reported. Cathode material is the key parameter to drive the electroreduction towards one or another chemical. 2,3-BD is the major chemical produced by electrohydrogenation when low hydrogen overvoltage cathodes, such as Pt and Ni, of high surface area obtained by PVD coating on a carbon gas diffusion layer are used, while MEK is the principal product produced by electrohydrogenolysis when high hydrogen overvoltage cathodes, such as graphite, Pb and Cd foils, are employed. 2,3-BD and MEK can be obtained, respectively, in 92.8% and 85.7% selectivities, 71.7% and 80.4% current efficiencies, with 1.21 and 1.08 kg.h-1.m-2 productivities and power consumptions of 2.94 and 4.1 kWh.kg-1 using undivided cells and aqueous K2HPO4 electrolysis media at pHs of 3.6 and 5.5. The reported electroconversion of acetoin is highly flexible because 2,3-BD and MEK can be produced by changing just the cathode but using the same cell, with the same electrolyte at the same current density

O papel da estratégia e estrutura organizacional na inovação não-P&D

Objective: this article analyzes the relationship between strategy and organizational structure in the framework of non-R&D innovation.Methodology: a systematic review of literature was carried out in which 64 articles from Scopus, Emerald and Proquest databases were identified.Originality: this study evidences a group of characteristics of the organizations and its sorroundings that contribute to the appearance of non-R&D activities and results of non-R&D innovation.Main results: 24 factors that enhance, condition or result from this type of innovation were determined.Theoretical contributions: as part of the findings, there stand out the identification of specific strategies, the importance of absorption capacity for understanding the phenomenon of non-R&D innovation, and the fact that most common innovations under this approach are marketing and organizational.Objetivo: el presente estudio analiza la relación de la estrategia y la estructura organizacional en el marco de la innovación no I+D.Metodología: se realizó una revisión sistemática de la literatura en la que se identificaron 64 artículos de las bases de datos Scopus, Emerald y Proquest.Originalidad: el presente estudio evidencia un conjunto de características, tanto de las organizaciones como del entorno, que contribuyen a la aparición de ANID y resultados de INID.Resultados principales: se determinaron 24 factores que potencian, condicionan o resultan de este tipo de innovación. Contribuciones teóricas: como parte de los hallazgos se destaca la identificación de estrategias puntuales, la importancia de la capacidad de absorción para el entendimiento del fenómeno de innovación no I+D y el hecho de que las innovaciones más comunes bajo este enfoque son de tipo mercadeo y organizacional.Objetivo: este estudo analisa a relação entre estratégia e estrutura organizacional no âmbito da inovação não-P&D.Metodologia: foi realizada uma revisão sistemática da literatura, na qual foram identificados 64 artigos das bases de dados Scopus, Emerald e Proquest.Originalidade: o presente estudo evidencia um conjunto de características, tanto das organizações quanto do meio ambiente, que contribuem para o surgimento dos resultados do ANID e do INID.Principais resultados: foram determinados 24 fatores que melhoram, condicionam ou resultam desse tipo de inovação.Contribuições teóricas: como parte dos resultados, destacam-se a identificação de estratégias específicas, a importância da capacidade de absorção para a compreensão do fenômeno da inovação não-P&D e o fato de que as inovações mais comuns sob essa abordagem são do tipo marketing. e organizacional

Participación de las mujeres en la Mesa Departamental de Participación Efectiva de las Víctimas del Conflicto Armado Interno del Chocó

Se presenta el informe final de investigación de trabajo de grado de maestría, que tiene como objetivo identificar los factores determinantes de la participación de las mujeres en la Mesa Departamental de Participación efectiva de las víctimas del conflicto armado en el Chocó. A partir de un estudio de caso, en el que se hará revisión documental del estado del arte y de la fundamentación teórico – conceptual, se identifican las dimensiones cualitativas a investigar, se hace un análisis de los resultados arrojados con la aplicación de las técnicas e instrumentos de recopilación de información para determinar las fortalezas y debilidades de la participación de las mujeres. La parte final presenta la estrategia construida a la luz de la investigación realizada, las conclusiones y recomendaciones originadas en el trabajo de investigación

Oropharyngeal Colostrum Positively Modulates the Inflammatory Response in Preterm Neonates

During the first days of life, premature infants have physiological difficulties swallowing, thereby missing out on the benefits of breastfeeding. The aim of this study is to assess the effects of oropharyngeal mother’s milk administration in the inflammatory signaling of extremely premature infants. Neonates (n = 100) (<32 week’s gestation and/or <1500 g) were divided into two groups: mother’s milk group (n = 48), receiving 0.2 mL of oropharyngeal mother’s milk every 4 h for the first 15 days of life, and a control group (n = 52), not receiving oropharyngeal mother’s milk. Serum concentrations of interleukin (IL) IL-6, IL-8, IL-10, IL-1ra, tumor necrosis factor alpha (TNF-a), and interferón gamma (IFN- y) were assessed at 1, 3, 15, and 30 days of postnatal life. Maternal and neonatal outcomes were collected. The rate of common neonatal morbidities in both groups was similar. The mother’s milk group achieved full enteral feeding earlier, and showed a decrease in Il-6 on days 15 and 30, in IL-8 on day 30, and in TNF-a and INF- y on day 15, as well as an increase in IL-1ra on days 3 and 15 and in IL-10 on day 30. Oropharyngeal mother’s milk administration for 15 days decreases the pro-inflammatory state of preterm neonates and provides full enteral nutrition earlier, which could have a positive influence on the development of the immune system and inflammatory response, thereby positively influencing other developmental outcomes

Clinical and Videofluoroscopic Characteristics of Oropharyngeal Dysphagia in Children Aged 1 Month to 5 Years. A Study in Medellín, Colombia, 2004

RESUMEN: Objetivo: describir, con base en las evaluaciones clínica y videofluoroscópica, las alteraciones biomecánicas más frecuentes en un grupo de niños entre un mes y cinco años de edad, con sospecha clínica de trastorno de la deglución (TD) en el Hospital Universitario San Vicente de Paúl (HUSVP). Metodología: estudio descriptivo de una muestra consecutiva entre enero 1 y diciembre 31 de 2004. La información se obtuvo con una encuesta estructurada. Se analizaron las siguientes variables: edad, sexo, antecedentes personales y evaluaciones clínica y videofluoroscópica de las fases de la deglución. Se hizo análisis estadístico con el software SPSS 11.0. Resultados: se estudiaron 68 pacientes con TD, 40 de ellos (58,8%) varones; a 48 se les hizo videofluoroscopia. Cincuenta y cuatro (79,4%) tenían edades entre 1-24 meses. Treinta niños (44,1%) tenían diagnóstico de parálisis cerebral; once (16,2%) presentaban anomalías congénitas estructurales de la orofaringe; 57 (83,8%) sufrían de alteraciones gastrointestinales, principalmente rehusar la alimentación y reflujo gastroesofágico. Del total de 68 niños, 27 (39,7%) tenían historia de neumonía recurrente y 11 (16,2%) presentaban antecedentes de otras condiciones respiratorias. No se encontraron diferencias estadísticamente significativas en la evaluación radiológica de la fase faríngea en los niños con y sin neumonía recurrente. La sensibilidad de la evaluación clínica de la fase oral fue 90% y la de la fase faríngea, 91,6%. No se encontró concordancia entre los exámenes clínico y radiológico del trastorno de deglución (Kappa 5,6%, intervalo de confianza del 95% (-0,042-0,154).ABSTRACT: Objective: to describe, based on clinical and videofluoroscopic evaluations, the most frequent biomechanical alterations in a group of children, aged 1 month to 5 years, with the clinical suspicion of swallowing disorders. Methodology: descriptive study of a consecutive sample of 68 patients, between January 1 and December 31, 2004, at a children´s hospital in Medellín, Colombia. Information was obtained by means of a structured survey. The following variables were analyzed: age, sex, personal medical history, and clinical and videofluoroscopic evaluations of the swallowing phases. Statistical analysis was carried out by means of the SPSS 11.0 software. Results: out of the 68 patients 40 (58.8%) were males. Children between 1-24 months represented 79.4% of the group. Videofluoroscopy was carried out in 48. Thirty children (44.1%) suffered from cerebral palsy; 11(16.2%) had congenital oropharyngeal anomalies; 57(83.8%) had gastrointestinal alterations, the most frequent of which were gastroesophageal reflux and refusal to feed. In 27 (39.7%) there was history of recurrent pneumonia, and 11 (16.2%) more suffered from other respiratory conditions. No significant differences were found in the radiological evaluation of the pharyngeal phase of swallowing between children with or without recurrent pneumonia. Sensitivity of the clinical evaluation was 90% for the oral phase of deglutition, and 91.6% for the pharyngeal phase. There was no agreement between the clinical and radiological evaluations of the swallowing disorder (Kappa 5.6, 95% confidence interval (-0.042-0.154)

Climatic impacts on the bacterial community profiles of cork oak soils

Climate changes comprise increasing global temperature and water cycle deregulation (precipitation storms and long dry seasons). Many affected ecosystems are located within the Mediterranean basin, where cork oak (Quercus suber L.) is one of the most important forest ecosystems. Despite cork oak tolerance to drought, the decrease of water availability and increase of temperature is causing a serious decline of cork oak populations. In the present work, the bacterial community of cork oak soils was assessed by metabarcoding using Illumina Miseq. Soils from seven independent cork oak forests were collected along a climate gradient. In all forest soils, Proteobacteria and Actinobacteria were the richest and more abundant bacteria. Acidobacteria also presented a high relative abundance, and Chloroflexi was a rich phylum. The soil bacterial community diversity and composition was strongly affected by the climatic region where cork oak resides and specific bacterial taxa were differently affected by precipitation and temperature. Accordingly, cork oak bacterial communities clustered into three distinct groups, related with humid, sub-humid and arid/semi-arid climates. Driest and warmer forests presented more diverse bacterial communities than humid and coolest forests. However, driest climates presented more homogenous bacterial communities among forests than humid climates. Climate (mainly precipitation) revealed to be the strongest driver leading to significant variations of bacterial community profiles. The most impacted bacterial taxa by climatic variables were Proteobacteria, in particular Gammaproteobacteria and Deltaproteobacteria, Chloroflexi, and Firmicutes. Humid forests presented mainly Acidobacteria as good indicators of climate, whereas Actinobacteria members were better indicators for arid forests (mainly Gaiellales and Frankiales). Some indicator species for different climate conditions were members of the bacterial core of cork oak stands (7% of the total bacterial community). Taken together, differentThis work was supported by FEDER through the Operational Competitiveness Program (COMPETE) and by Portuguese national funds through the Foundation for Science and Technology (FCT) within the scope of the project POCI-01-0145-FEDER-028635; FCT/MCTES/PIDDAC (Portugal) under the project (PEst-OE/BIA/UI4046/2014; UID/MULTI/04046/2013) and PhD grant to F.R. (SFRH/BD/86519/2012)

Single-cell profiling reveals an endothelium-mediated immunomodulatory pathway in the eye choroid

The activity and survival of retinal photoreceptors depend on support functions performed by the retinal pigment epithelium (RPE) and on oxygen and nutrients delivered by blood vessels in the underlying choroid. By combining single-cell and bulk RNA sequencing, we categorized mouse RPE/choroid cell types and characterized the tissue-specific transcriptomic features of choroidal endothelial cells. We found that choroidal endothelium adjacent to the RPE expresses high levels of Indian Hedgehog and identified its downstream target as stromal GLI1+ mesenchymal stem cell-like cells. In vivo genetic impairment of Hedgehog signaling induced significant loss of choroidal mast cells, as well as an altered inflammatory response and exacerbated visual function defects after retinal damage. Our studies reveal the cellular and molecular landscape of adult RPE/choroid and uncover a Hedgehog-regulated choroidal immunomodulatory signaling circuit. These results open new avenues for the study and treatment of retinal vascular diseases and choroid-related inflammatory blinding disorders.Funding for this study was provided by National Institutes of Health grants EY08538 and GM34107 (E. Rodriguez-Boulan); EY027038 (R.F. Mullins); 1R21CA224391-01A1 (J.H. Zippin); and 1R01CA194547, 1U24CA210989, and P50CA211024 (O. Elemento); National Cancer Institute grant R01CA192176 and cancer center support grant P30 CA008748-48 (A.L. Joyner); Comunidad Autónoma de Madrid grant 2017-T1/BMD-5247 (I. Benedicto); Agencia Nacional Argentina de Promoción Cient´ıfica y Tecnológica grant PICT 2014-3687 and Fundación Sales (G.A. Rabinovich); a Pew Latin American Fellowship (G.L. Lehmann); Calder Research Scholar Award Vitiligo/Pigment Cell Disorders (J.H. Zippin); Starr Foundation Tri-Institutional Stem Cell Initiative award 2013-028; NYSTEM contract C32596GG; and Research to Prevent Blindness and Dyson Foundation departmental grants. The CNIC is supported by the Instituto de Salud Carlos III, the Ministerio de Ciencia e Innovación, and the Pro CNIC Foundation and is a Severo Ochoa Center of Excellence (SEV-2015-0505).S

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements