Soft OR and practice : the contribution of the founders of Operation Research

This paper explores the work of some 43 founders of operations research. In particular, it considers the links between soft operations research (OR) and these founders. Several of the founders were direct influencers of the soft OR proponents, whereas others related to the context, process, and content of soft OR. Coupled with the deductive and inductive reasoning approaches of soft OR, it is argued that soft OR is a legitimate branch of OR. The paper also focuses on the embeddedness of the founders, and the soft OR proponents, in practice and argues that, for academics, engagement with practice has been and will continue to be an important driver for the health and development of operations research

Establishing a bioconversion process for the production of succinic acid using industrial feedstocks.

Masters Degree. University of KwaZulu-Natal, Durban.One of the leading challenges of the current global situation is the decline of non-renewable, fossil fuels. Due to this rapid depletion, there is a shift towards replacing petrochemical products with equivalent, ideally superior bio-based substitutes. The bio-chemical of interest that was studied in this work is bio-succinic acid which is considered a platform chemical. Bio-based procedures have the attractive advantage of potentially obtaining a high-value product from an underutilised product/waste stream. In this dissertation, the industry that was focused on was the sugar sector, this vital industry is under pressure it is therefore crucial that alternative revenue avenues are identified. A literature study highlighted the importance of succinic acid, detailed both the upstream and downstream literature methods and addressed the impact that biochemical processes could have within South Africa. Small scale flask studies were conducted using succinate-producing microorganisms, on synthetic C5 and C6 sugar medias, namely xylose and glucose. The results from these studies showed that L. paracasei and C. glutamicum were the top performing strains on the C6 sugar (glucose) media and as a result these strains were then grown on C6 industrial material, namely sugarcane juice and molasses. These flask studies concluded that C. glutamicum grown on molasses was the superior combination, with a succinic acid concentration of 18.81 ± 0.75 g.L-1 and a productivity of 0.67 ± 0.07 g.L-1.hr-1 being achieved. The process was then successfully scaled up to 30L reactors where a succinic acid concentration of 28.89 ± 3.57 g.L-1 was reached, which was higher than the ‘ideal’ glucose reactor run. Downstream processing of the harvested broth was conducted using the precipitation method. Process development was performed, and the final method resulted in a final succinic acid recovery of 54.47 ± 14.02 % and 58.20 ± 2.24 % for the glucose and molasses-based medias respectively. In conclusion, molasses has the potential as an alternative carbon source in the production of succinic acid. The biochemicals sector is still a novel concept within South Africa, and as this platform gains more traction such studies show the ‘value’ of industry’s waste/by-product streams, especially for the sugar industry

Cultivating a Resilient Response to Stress through Mindfulness and Cognitive Re-appraisal: A Pilot Randomised Control Trial

The capacity for human service professionals to replenish resilience is important to their health and psychological wellbeing. The current study evaluated a brief Mindful Awareness and Resilience Skills Training (MARST) program designed to enhance mindfulness and positive re-appraisal as psychological mechanisms for increasing resilience, decreasing psychological distress and perceived stress. This program was informed by the Mindful-Cognitive Model of Cultivating Resilience. A sample of 46 human service professionals were randomly allocated to a MARST group or control group. Short term and follow-up training effects were examined using MANOVA. At post-training, the MARST group reported significantly higher levels of resilience, mindfulness and positive re-appraisal compared to the control group. At one-month follow-up, the MARST group reported significantly higher levels of resilience, mindfulness, and positive re-appraisal, and significantly lower levels of perceived stress and psychological distress relative to the control group. The findings provide preliminary support for the efficacy of the MARST program to increase resilience and decrease levels of psychological distress and perceived stress among human services professionals

The relationship of milk expression pattern and lactation outcomes after very premature birth: A cohort study

Introduction: Mothers of very premature infants often have difficulties expressing breastmilk, which can cause distress and potential negative impact on infant health. Clinical recommendations on breastmilk expression are extrapolated from term infants’ breastfeeding patterns. This study’s objective was to analyse the association of expressing pattern with lactation outcomes after very premature birth. Methods: 132 participants were recruited after birth between 23+0 and 31+6 weeks’ gestation. Participants recorded the milk expressed in several 24-hour periods in the three weeks after birth. Results: Expressing frequency was positively associated with 24-hour milk yield, with an adjusted 30.5g increase per expressing session on day four (95% CI 15.7 to 45.3) and 94.4g on day 21 (95% CI 62.7 to 126.2). Expressing ≥8 times per day was associated with higher adjusted milk yield than expressing <6 times (on day four, 146.8g, 95% CI 47.4 to 246.1), but not in comparison to expressing 6–7 times (on day four, 82.1g, 95% CI –25.9 to 190.1). Participants with six months or more prior breastmilk feeding experience had a higher adjusted milk yield than others (on day four, 204.3g, 95% CI 125.2 to 283.3). Night-time (2300–0700 hours) expressing sessions were not associated with increased milk yield after adjustment for time since the prior session. On average, participants who had a longest gap between expressions of less than six hours achieved the UK target of 750g breastmilk, whereas those with a longer gap did not. Conclusion: Expressing frequency was an important determinant of milk yield. Clinical recommendations to express ≥8 times per day were supported but for some, 6–7 times was sufficient. This was particularly likely for those with six months or more of prior breastmilk feeding experience. A need to express during the night-time hours appeared to be related to minimising the gap between expressions rather than an inherent value of night-time expression

Repurposing literacy: the uses of Richard Hoggart for creative education

After 50 years, what are the implications of Uses of Literacy for educational modernisation, in the light of subsequent changes from 'read only' literacy to 'read-write' uses of multimedia? This chapter argues that a broad extension of popular literacy via consumer-created digital content offers not only emancipationist potential in line with Hoggart's own project, but also economic benefits via the dynamics of creative innovation. Multimedia 'popular entertainments' pose a challenge to formal education, but not in the way that Hoggart feared. Instead of producing 'tamed helots,' commercial culture may be outpacing formal schooling in promoting creative digital literacy via entrepreneurial and distributed learning. It may indeed be that those in need of a creative make-over are not teenagers but teachers

Re-imagining the data collection and analysis research process by proposing a rapid qualitative data collection and analytic roadmap applied to the dynamic context of precision medicine

Our implementation science study focuses on implementing a new way of practice and offers methodological specificity about how to rapidly investigate an individually tailored precision medicine intervention. A qualitative study advancing a new methodology for speedily identifying barriers and enablers to implementation in the context of childhood cancer. Data were collected through rapid ethnography, coded using the Consolidated Framework for Implementation Research, and analysed by Sentiment Analysis. Thirty-eight data collection events occurred during 14 multidisciplinary tumour board meetings, 14 curation meetings, and 10 informal conversations. Sentiment Analysis distilled Consolidated Framework for Implementation Research codes to reveal key barriers and enablers to implementation. A traffic light labelling system has been used to present levels of positivity and negativity (green for strong enablers and red for strong barriers), highlighting levels of concern regarding implementation. Within the intervention design characteristics, “Adaptability” was the strongest enabler and “Design quality and safety” the strongest barrier. Among the contextual factors: “Networks and communication” were the strongest enabler, and “Available resources” were the strongest barrier. Overall, there was a higher percentage of negative sentiment towards intervention design characteristics and contextual factors than positive sentiment, while more concerns were raised about intervention design factors than contextual factors. This study offers a rapid qualitative data collection and analytic methodological roadmap for establishing barriers and enablers to a paediatric precision medicine intervention

The Association of Persistent Symptoms of Depression and Anxiety with Recurrent Acute Coronary Syndrome Events: A Prospective Observational Study

The purpose of this study was to examine the role of persistent symptoms of depression and anxiety in a second acute coronary syndrome (ACS) event. Data presented in this study were from an RCT study. A follow-up for 24 months after baseline to detect a second ACS event among 1162 patients from five hospitals. Hierarchal Cox regression analyses were used. The results showed that persistent depression only (HR 2.27; 95% CI: 1.35–3.81; p = 0.002), and comorbid persistent depression and anxiety (HR 2.03; 95% CI: 1.03–3.98; p = 0.040) were the significant predictors of a second ACS event. Secondary education level compared to primary educational level (HR 0.63; 95% CI: 0.43–0.93; p = 0.020) and college or more education level compared to primary educational level (HR 0.47; 95% CI: 0.27–0.84; p = 0.011) were the only demographic variables that were significant predictors of a second event. The study reveals that attention must be paid by healthcare providers to assess and manage persistent depression; particularly when it is co-morbid with anxiety

A Genetic Animal Model of Alcoholism for Screening Medications to Treat Addiction

The purpose of this review is to present up-to-date pharmacological, genetic, and behavioral findings from the alcohol-preferring P rat and summarize similar past work. Behaviorally, the focus will be on how the P rat meets criteria put forth for a valid animal model of alcoholism with a highlight on its use as an animal model of polysubstance abuse, including alcohol, nicotine, and psychostimulants. Pharmacologically and genetically, the focus will be on the neurotransmitter and neuropeptide systems that have received the most attention: cholinergic, dopaminergic, GABAergic, glutamatergic, serotonergic, noradrenergic, corticotrophin releasing hormone, opioid, and neuropeptide Y. Herein, we sought to place the P rat's behavioral and neurochemical phenotypes, and to some extent its genotype, in the context of the clinical literature. After reviewing the findings thus far, this chapter discusses future directions for expanding the use of this genetic animal model of alcoholism to identify molecular targets for treating drug addiction in general

Secondary prevention after ischaemic stroke: the ASPIRE-S study

BACKGROUND: Survivors of ischaemic stroke (IS) are at high-risk for future vascular events. Comprehensive information on the adequacy of secondary prevention after IS is lacking despite the knowledge that appropriate secondary prevention improves long-term patient outcomes. ASPIRE-S (Action on Secondary Prevention Interventions and Rehabilitation in Stroke) aimed to prospectively assess secondary prevention in patients 6 months following IS. METHODS: Consenting patients admitted with IS to three Dublin hospitals were recruited over 1 year, from October 2011. At 6 months post IS a comprehensive assessment was completed, modelled on the EUROASPIRE protocol for evaluation of the adequacy of secondary prevention in post-discharge cardiac patients. This assessment included measurements of blood pressure, body mass index and fasting lipid and glucose profiles. Secondary preventive medications and smoking status were also documented. RESULTS: Three hundred two patients (58 % male) participated, of whom 256 (85 %) were followed-up at 6 months. Mean age was 69 years (range 22–95). At follow-up, 68 % of patients had a BMI >25 kg/m(2) and 16.4 % were still smoking. Almost two-thirds (63.4 %) had a blood pressure >140/90 and 23 % had low-density-lipoprotein >2.5 mmol/L. 28 % of diabetic patients had HbA1c ≥7 %. Ninety seven percent of patients were on anti-platelet and/or anticoagulant therapy. Of those with atrial fibrillation, 82 % were anti-coagulated (mean INR of 2.4). Ninety-five percent were on lipid-lowering therapy and three-quarters were on anti-hypertensive therapy. CONCLUSION: This prospective multi-centre survey of IS patients demonstrated a high prevalence of remaining modifiable risk factors at 6 months post stroke, despite the widespread prescription of secondary preventive medications. There is scope to improve preventive measures after IS (in particular blood pressure) by incorporating evidence-based guidelines into quality assurance cycles in stroke care