1,736 research outputs found
Training, status and migration of general practitioners / family physicians within Europe
The survey intended to explore and identify the
training background and status of general practitioners/
family physicians (GPs) in member countries within
EURACT (European Academy of Teachers in General
Practice/Family Medicine), and to gain an overview of
processes involved when GP-trained doctors migrate to
work in another member country. A questionnaire, with closed and open-ended
questions, was sent to representatives of all 39
EURACT-member countries in 2009. The main outcome
measures were the training background and status of
GPs in public/private settings in each country and the
requirements of additional training and testing when
migrating to another country. Forty-one completed questionnaires were received
from 31 (79%) of the EURACT countries. The data
indicate that specialist training for General Practice/
Family Medicine (GP/FM) is well established throughout
and generally required for appointment to public career
posts. The data also indicate that European Uniontrained
GPs can move freely to most countries with
usually no tests of medical knowledge or language
proficiency. Orientation to the healthcare system in the
destination country is usually not provided. work in public/private GP/FM posts in many European
countries, although new appointments to public posts
RESEARCH ARTICLE
Training, status and migration
of General Practitioners/Family
Physicians within Europe
in nearly all countries require specialist GP training.
It was not possible to identify a uniform or agreed
approach applied by employing agencies to confirm
the medical competence and language skills of migrant
doctors and to provide them with orientation to
healthcare systems. In the high-context dependent
discipline of GP/FM this is of concern.peer-reviewe
Linking local movement and molecular analysis to explore philopatry and population connectivity of the southern stingray Hypanus americanus
Peer reviewedPublisher PD
Drivers of octopus abundance and density in an anchialine lake: a 30 year comparison
Anchialine systems are isolated from the sea and often support speciesâ populations distinct from their marine counterparts. Sweetings Pond, an anchialine lake on the island of Eleuthera in The Bahamas was identified as a site of high Caribbean reef octopus, Octopus briareus (Robson, 1929) density, relative to coastal populations. However, observed deterioration in local benthic habitat and increased anthropogenic influence over the last 30 years imply that this octopus population may have undergone density and distribution shifts in response to these changing conditions. Here, we assess the system wide octopus density to provide an updated estimate. We hypothesize that despite depressed habitat availability in the 1980s, it will now support octopus densities less than historical estimates because of increasing human impact on the system. Drivers of abundance were also modelled, testing ecological hypotheses of the relationship between octopus count and prey, habitat coverage, and human disturbance. Octopus briareus were found in 7 of 27 of surveys with a mean survey count of 0.630 ± 1.25 per 900 m2. Octopus density did not vary significantly between sites. Octopus count was predicted to increase with increasing cover of calcareous rubble and the density of a preferred prey species, and intriguingly, counts decreased as a function of natural den abundance. System wide octopus density was comparable to earlier studies from the 1980s (1982 = 717.38 per km2; 1983 = 282.59 per km2; 2019 = 643.81 per km2) with no significant difference between years. Given the ecosystemâs unique and closed ecological community and the population dynamics and distribution drivers we present, Sweetings Pond has the potential to act as a ânatural laboratoryâ to explore further questions about marine insular systems and their influence on species populations in terms of ecological and behavioural change
The cosmological simulation code GADGET-2
We discuss the cosmological simulation code GADGET-2, a new massively
parallel TreeSPH code, capable of following a collisionless fluid with the
N-body method, and an ideal gas by means of smoothed particle hydrodynamics
(SPH). Our implementation of SPH manifestly conserves energy and entropy in
regions free of dissipation, while allowing for fully adaptive smoothing
lengths. Gravitational forces are computed with a hierarchical multipole
expansion, which can optionally be applied in the form of a TreePM algorithm,
where only short-range forces are computed with the `tree'-method while
long-range forces are determined with Fourier techniques. Time integration is
based on a quasi-symplectic scheme where long-range and short-range forces can
be integrated with different timesteps. Individual and adaptive short-range
timesteps may also be employed. The domain decomposition used in the
parallelisation algorithm is based on a space-filling curve, resulting in high
flexibility and tree force errors that do not depend on the way the domains are
cut. The code is efficient in terms of memory consumption and required
communication bandwidth. It has been used to compute the first cosmological
N-body simulation with more than 10^10 dark matter particles, reaching a
homogeneous spatial dynamic range of 10^5 per dimension in a 3D box. It has
also been used to carry out very large cosmological SPH simulations that
account for radiative cooling and star formation, reaching total particle
numbers of more than 250 million. We present the algorithms used by the code
and discuss their accuracy and performance using a number of test problems.
GADGET-2 is publicly released to the research community.Comment: submitted to MNRAS, 31 pages, 20 figures (reduced resolution), code
available at http://www.mpa-garching.mpg.de/gadge
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Engaging excellence? Effects of faculty quality on university engagement with industry
Quantifying the impact of BOReal forest fires on Tropospheric oxidants over the Atlantic using Aircraft and Satellites (BORTAS) experiment: design, execution and science overview
We describe the design and execution of the BORTAS (Quantifying the impact of BOReal forest fires on Tropospheric oxidants over the Atlantic using Aircraft and Satellites) experiment, which has the overarching objective of understanding the chemical aging of air masses that contain the emission products from seasonal boreal wildfires and how these air masses subsequently impact downwind atmospheric composition. The central focus of the experiment was a two-week deployment of the UK BAe-146-301 Atmospheric Research Aircraft (ARA) over eastern Canada, based out of Halifax, Nova Scotia. Atmospheric ground-based and sonde measurements over Canada and the Azores associated with the planned July 2010 deployment of the ARA, which was postponed by 12 months due to UK-based flights related to the dispersal of material emitted by the Eyjafjallajökull volcano, went ahead and constituted phase A of the experiment. Phase B of BORTAS in July 2011 involved the same atmospheric measurements, but included the ARA, special satellite observations and a more comprehensive ground-based measurement suite. The high-frequency aircraft data provided a comprehensive chemical snapshot of pyrogenic plumes from wildfires, corresponding to photochemical (and physical) ages ranging from 45 sr 10 days, largely by virtue of widespread fires over Northwestern Ontario. Airborne measurements reported a large number of emitted gases including semi-volatile species, some of which have not been been previously reported in pyrogenic plumes, with the corresponding emission ratios agreeing with previous work for common gases. Analysis of the NOy data shows evidence of net ozone production in pyrogenic plumes, controlled by aerosol abundance, which increases as a function of photochemical age. The coordinated ground-based and sonde data provided detailed but spatially limited information that put the aircraft data into context of the longer burning season in the boundary layer. Ground-based measurements of particulate matter smaller than 2.5 ÎŒm (PM2.5) over Halifax show that forest fires can on an episodic basis represent a substantial contribution to total surface PM2.5
Effects of intrauterine exposure to synthetic glucocorticoids on fetal, newborn, and infant hypothalamic-pituitary-adrenal axis function in humans : a systematic review
BACKGROUND: Synthetic glucocorticoids are commonly used in reproductive medicine. Fetal organ systems are highly sensitive to changes in the intrauterine environment, including overexposure to glucocorticoids. Structural and functional alterations resulting from such changes may persist throughout life and have been associated with diverse diseases. One system that could be particularly sensitive to fetal glucocorticoid overexposure is the hypothalamic-pituitary-adrenal (hpa) axis. Many human studies have investigated this possibility, but a systematic review to identify consistent, emergent findings is lacking. METHODS: We systematically review 49 human studies, assessing the effects of intrauterine exposure to synthetic glucocorticoids on fetal, neonate, and infant hpa function. RESULTS: Study quality varied considerably, but the main findings held true after restricting the analyses to higher-quality studies: intrauterine exposure to synthetic glucocorticoids reduces offspring hpa activity under unstimulated conditions after pain but not pharmacological challenge. Although reduced unstimulated hpa function appears to recover within the first 2 wk postpartum, blunted hpa reactivity to pain is likely to persist throughout the first 4 months of life. There is some evidence that the magnitude of the effects is correlated with the total amount of glucocorticoids administered and varies with the time interval between glucocorticoid exposure and hpa assessment. CONCLUSIONS: This systematic review has allowed the demonstration of the way in which intrauterine exposure to various regimens of synthetic glucocorticoids affects various forms of hpa function. As such, it guides future studies in terms of which variables need to be focused on in order to further strengthen the understanding of such therapy, whilst continuing to profit from its clinical benefits
Phosphorylation of p65(RelA) on Ser547 by ATM Represses NF-ÎșB-Dependent Transcription of Specific Genes after Genotoxic Stress
The NF-ÎșB pathway is involved in immune and inflammation responses, proliferation, differentiation and cell death or survival. It is activated by many external stimuli including genotoxic stress. DNA double-strand breaks activate NF-ÎșB in an ATM-dependent manner. In this manuscript, a direct interaction between p65(RelA) and the N-terminal extremity of ATM is reported. We also report that only one of the five potential ATM-(S/T)Q target sites present in p65, namely Ser547, is specifically phosphorylated by ATM in vitro. A comparative transcriptomic analysis performed in HEK-293 cells expressing either wild-type HA-p65 or a non-phosphorylatable mutant HA-p65S547A identified several differentially transcribed genes after an etoposide treatment (e.g. IL8, A20, SELE). The transcription of these genes is increased in cells expressing the mutant. Substitution of Ser547 to alanine does not affect p65 binding abilities on the ÎșB site of the IL8 promoter but reduces p65 interaction with HDAC1. Cells expressing p65S547A have a higher level of histone H3 acetylated on Lys9 at the IL8 promoter, which is in agreement with the higher gene induction observed. These results indicate that ATM regulates a sub-set of NF-ÎșB dependent genes after a genotoxic stress by direct phosphorylation of p65
The JNK Pathway Regulates the In Vivo Deletion of Immature CD4+CD8+ Thymocytes
The extracellular signal-regulated kinase (ERK), the c-Jun NH2-terminal kinase (JNK), and p38 MAP kinase pathways are triggered upon ligation of the antigen-specific T cell receptor (TCR). During the development of T cells in the thymus, the ERK pathway is required for differentiation of CD4âCD8â into CD4+CD8+ double positive (DP) thymocytes, positive selection of DP cells, and their maturation into CD4+ cells. However, the ERK pathway is not required for negative selection. Here, we show that JNK is activated in DP thymocytes in vivo in response to signals that initiate negative selection. The activation of JNK in these cells appears to be mediated by the MAP kinase kinase MKK7 since high levels of MKK7 and low levels of Sek-1/MKK4 gene expression were detected in thymocytes. Using dominant negative JNK transgenic mice, we show that inhibition of the JNK pathway reduces the in vivo deletion of DP thymocytes. In addition, the increased resistance of DP thymocytes to cell death in these mice produces an accelerated reconstitution of normal thymic populations upon in vivo DP elimination. Together, these data indicate that the JNK pathway contributes to the deletion of DP thymocytes by apoptosis in response to TCR-derived and other thymic environmentâ mediated signals
Measurement of the inclusive and dijet cross-sections of b-jets in pp collisions at sqrt(s) = 7 TeV with the ATLAS detector
The inclusive and dijet production cross-sections have been measured for jets
containing b-hadrons (b-jets) in proton-proton collisions at a centre-of-mass
energy of sqrt(s) = 7 TeV, using the ATLAS detector at the LHC. The
measurements use data corresponding to an integrated luminosity of 34 pb^-1.
The b-jets are identified using either a lifetime-based method, where secondary
decay vertices of b-hadrons in jets are reconstructed using information from
the tracking detectors, or a muon-based method where the presence of a muon is
used to identify semileptonic decays of b-hadrons inside jets. The inclusive
b-jet cross-section is measured as a function of transverse momentum in the
range 20 < pT < 400 GeV and rapidity in the range |y| < 2.1. The bbbar-dijet
cross-section is measured as a function of the dijet invariant mass in the
range 110 < m_jj < 760 GeV, the azimuthal angle difference between the two jets
and the angular variable chi in two dijet mass regions. The results are
compared with next-to-leading-order QCD predictions. Good agreement is observed
between the measured cross-sections and the predictions obtained using POWHEG +
Pythia. MC@NLO + Herwig shows good agreement with the measured bbbar-dijet
cross-section. However, it does not reproduce the measured inclusive
cross-section well, particularly for central b-jets with large transverse
momenta.Comment: 10 pages plus author list (21 pages total), 8 figures, 1 table, final
version published in European Physical Journal
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