A comprehensive interpretative model of slow slip events on Mt. Etna’s eastern flank

Starting off from a review of previous literature on kinematic models of the unstable eastern flank of Mt. Etna, we propose a new model. The model is based on our analysis of a large quantity of multidisciplinary data deriving from an extensive and diverse network of INGV monitoring devices deployed along the slopes of the volcano. Our analysis had a twofold objective: first, investigating the origin of the recently observed slow-slip events on the eastern flank of Mt. Etna; and second, defining a general kinematic model for the instability of this area of the volcano. To this end, we investigated the 2008–2013 period using data collected from different geochemical, geodetic, and seismic networks, integrated with the tectonic and geologic features of the volcano and including the volcanic activity during the observation period. The complex correlations between the large quantities of multidisciplinary data have given us the opportunity to infer, as outlined in this work, that the fluids of volcanic origin and their interrelationship with aquifers, tectonic and morphological features play a dominant role in the large scale instability of the eastern flank of Mt. Etna. Furthermore, we suggest that changes in the strain distribution due to volcanic inflation/deflation cycles are closely connected to changes in shallow depth fluid circulation. Finally, we propose a general framework for both the short and long term modeling of the large flank displacements observed.Published635–6581IT. Reti di monitoraggio e OsservazioniJCR Journalrestricte

Pre-Existing T- and B-Cell Defects in One Progressive Multifocal Leukoencephalopathy Patient

Progressive multifocal leukoencephalopathy (PML) usually occurs in patients with severe immunosuppression, hematological malignancies, chronic inflammatory conditions or receiving organ transplant. Recently, PML has also been observed in patients treated with monoclonal antibodies. By taking advantage of the availability of samples from a multiple sclerosis (MS) patient treated with natalizumab, the antibody anti-α4 integrin, who developed PML and was monitored starting before therapy initiation, we investigated the fate of T and B lymphocytes in the onset of PML. Real-time PCR was used to measure new T- and B-cell production by means of T-cell receptor excision circle (TREC) and K-deleting recombination excision circle (KREC) analysis and to quantify transcripts for CD34, terminal-deoxynucleotidyltransferase, and V pre-B lymphocyte gene 1. T- and B-cell subsets and T-cell heterogeneity were measured by flow cytometry and spectratyping. The data were compared to those of untreated and natalizumab-treated MS patients and healthy donors. Before therapy, a patient who developed PML had a low TREC and KREC number; TRECs remained low, while KRECs and pre-B lymphocyte gene 1 transcripts peaked at 6 months of therapy and then decreased at PML diagnosis. Flow cytometry confirmed the deficient number of newly produced T lymphocytes, counterbalanced by an increase in TEMRA cells. The percentage of naive B cells increased by approximately 70% after 6 months of therapy, but B lymphocyte number remained low for the entire treatment period. T-cell heterogeneity and immunoglobulins were reduced

Search for massive resonances decaying in to WW,WZ or ZZ bosons in proton-proton collisions at root s=13 TeV

Peer reviewe

Search for long-lived charged particles in proton-proton collisions at root s=13 TeV

Peer reviewe

Measurement of prompt and nonprompt J/psi production in pp and pPb collisions at root s(NN)=5.02 TeV

Peer reviewe

Consensus guidelines for the use and interpretation of angiogenesis assays

The formation of new blood vessels, or angiogenesis, is a complex process that plays important roles in growth and development, tissue and organ regeneration, as well as numerous pathological conditions. Angiogenesis undergoes multiple discrete steps that can be individually evaluated and quantified by a large number of bioassays. These independent assessments hold advantages but also have limitations. This article describes in vivo, ex vivo, and in vitro bioassays that are available for the evaluation of angiogenesis and highlights critical aspects that are relevant for their execution and proper interpretation. As such, this collaborative work is the first edition of consensus guidelines on angiogenesis bioassays to serve for current and future reference

Differential cross section measurements for the production of a W boson in association with jets in proton–proton collisions at √s = 7 TeV

Measurements are reported of differential cross sections for the production of a W boson, which decays into a muon and a neutrino, in association with jets, as a function of several variables, including the transverse momenta (pT) and pseudorapidities of the four leading jets, the scalar sum of jet transverse momenta (HT), and the difference in azimuthal angle between the directions of each jet and the muon. The data sample of pp collisions at a centre-of-mass energy of 7 TeV was collected with the CMS detector at the LHC and corresponds to an integrated luminosity of 5.0 fb[superscript −1]. The measured cross sections are compared to predictions from Monte Carlo generators, MadGraph + pythia and sherpa, and to next-to-leading-order calculations from BlackHat + sherpa. The differential cross sections are found to be in agreement with the predictions, apart from the pT distributions of the leading jets at high pT values, the distributions of the HT at high-HT and low jet multiplicity, and the distribution of the difference in azimuthal angle between the leading jet and the muon at low values.United States. Dept. of EnergyNational Science Foundation (U.S.)Alfred P. Sloan Foundatio