72 research outputs found
Clinical practice guideline on the optimal radiotherapeutic management of brain metastases
- Author
- AH Mintz
- AR Harwood
- B Borgelt
- C Haie-Meder
- D Antonadou
- D Kondziolka
- DW Andrews
- EM Noordijk
- F Lohr
- F Mornex
- G Borgelt
- G Robinet
- GP Browman
- GP Browman
- HJ Eyre
- J Horton
- JM Kurtz
- JS Loeffler
- KJ Murray
- LM DeAngelis
- LT Komarnicky
- M Chatani
- M Chatani
- May N Tsao
- MN Tsao
- MP Mehta
- MP Mehta
- Nancy S Lloyd
- PB Chougule
- PE Postmus
- PW Sperduto
- PW Sperduto
- RA Patchell
- RA Patchell
- Rebecca KS Wong
- TJ Priestman
- TL Phillips
- Y Ushio
- Publication venue
- BioMed Central
- Publication date
- 01/01/2005
- Field of study
BACKGROUND: An evidence-based clinical practice guideline on the optimal radiotherapeutic management of single and multiple brain metastases was developed. METHODS: A systematic review and meta-analysis was performed. The Supportive Care Guidelines Group formulated clinical recommendations based on their interpretation of the evidence. External review of the report by Ontario practitioners was obtained through a mailed survey, and final approval was obtained from Cancer Care Ontario's Practice Guidelines Coordinating Committee (PGCC). RESULTS: One hundred and nine Ontario practitioners responded to the survey (return rate 44%). Ninety-six percent of respondents agreed with the interpretation of the evidence, and 92% agreed that the report should be approved. Minor revisions were made based on feedback from external reviewers and the PGCC. The PGCC approved the final practice guideline report. CONCLUSIONS: For adult patients with a clinical and radiographic diagnosis of brain metastases (single or multiple) we conclude that, • Surgical excision should be considered for patients with good performance status, minimal or no evidence of extracranial disease, and a surgically accessible single brain metastasis. • Postoperative whole brain radiotherapy (WBRT) should be considered to reduce the risk of tumour recurrence for patients who have undergone resection of a single brain metastasis. • Radiosurgery boost with WBRT may improve survival in select patients with unresectable single brain metastases. • The whole brain should be irradiated for multiple brain metastases. Standard dose-fractionation schedules are 3000 cGy in 10 fractions or 2000 cGy in 5 fractions. • Radiosensitizers are not recommended outside research studies. • In select patients, radiosurgery may be considered as boost therapy with WBRT to improve local tumour control. Radiosurgery boost may improve survival in select patients. • Chemotherapy as primary therapy or chemotherapy with WBRT remains experimental. • Supportive care is an option but there is a lack of Level 1 evidence as to which subsets of patients should be managed with supportive care alone. Qualifying statements addressing factors to consider when applying these recommendations are provided in the full report. The rigorous development, external review and approval process has resulted in a practice guideline that is strongly endorsed by Ontario practitioners
Marked alveolar apoptosis/proliferation imbalance in end-stage emphysema
- Author
- A Barbato
- AM Vignola
- CB Thompson
- E Ogawa
- F Calabrese
- G Cattoretti
- GL Snider
- H Takizawa
- H. Kanazawa
- J Majo
- J Massague
- JB Orens
- K Aoshiba
- K Haneda
- L Fjellbirkeland
- L Segura-Valdez
- M Kanoh
- M Lutz
- M May
- M Valente
- MD Linden
- MM Kockx
- MN Sheppard
- N Yokohori
- PA Hall
- PK Arora
- PN Tsao
- R Shtrichman
- RA Pauwels
- RD Hautamaki
- RM Tuder
- S Hodge
- WA Pryor
- Y Gavrieli
- Y Kasahara
- Y Kasahara
- Y Takubo
- Publication venue
- BioMed Central
- Publication date
- 01/01/2005
- Field of study
BACKGROUND: Apoptosis has recently been proposed to contribute to the pathogenesis of emphysema. METHODS: In order to establish if cell fate plays a role even in end-stage disease we studied 16 lungs (9 smoking-associated and 7 α1antitrypsin (AAT)-deficiency emphysema) from patients who had undergone lung transplantations. Six unused donor lungs served as controls. Apoptosis was evaluated by TUNEL analysis, single-stranded DNA laddering, electron microscopy and cell proliferation by an immunohistochemical method (MIB1). The role of the transforming growth factor (TGF)-β1 pathway was also investigated and correlated with epithelial cell turnover and with the severity of inflammatory cell infiltrate. RESULTS: The apoptotic index (AI) was significantly higher in emphysematous lungs compared to the control group (p ≤ 0.01), particularly if only lungs with AAT-deficiency emphysema were considered (p ≤ 0.01 vs p = 0.09). The proliferation index was similar in patients and controls (1.9 ± 2.2 vs 1.7 ± 1.1). An increased number of T lymphocytes was observed in AAT-deficiency lungs than smoking-related cases (p ≤ 0.05). TGF-β1 expression in the alveolar wall was higher in patients with smoking-associated emphysema than in cases with AAT-deficiency emphysema (p ≤ 0.05). A positive correlation between TGF-βRII and AI was observed only in the control group (p ≤ 0.005, r(2 )= 0.8). A negative correlation was found between the TGF-β pathway (particularly TGF-βRII) and T lymphocytes infiltrate in smoking-related cases (p ≤ 0.05, r(2 )= 0.99) CONCLUSION: Our findings suggest that apoptosis of alveolar epithelial cells plays an important role even in end-stage emphysema particularly in AAT-deficiency disease. The TGFβ-1 pathway does not seem to directly influence epithelial turnover in end-stage disease. Inflammatory cytokine different from TGF-β1 may differently orchestrate cell fate in AAT and smoking-related emphysema types
Akt phosphorylation on Thr308 but not on Ser473 correlates with Akt protein kinase activity in human non-small cell lung cancer
- Author
- A Goswami
- A Slipicevic
- AS Tsao
- B Solomon
- B Vanhaesebroeck
- BD Manning
- BR Balsara
- C Morgan
- D J E Elder
- DA Altomare
- DD Sarbassov
- DL Dai
- DR Alessi
- DR Alessi
- E C Thomas
- E E Vincent
- EB Nascimento
- G Perez-Tenorio
- H Sun
- J Feng
- J Li
- J M Tavaré
- J Pawade
- J Tsurutani
- JM Tang
- JN Andersen
- JQ Cheng
- KE O’Reilly
- KM Geraghty
- L Phillips
- LC Cantley
- LR Pearce
- M Hanada
- M R Hetzel
- M Sohail
- M T May
- MM Hill
- N Gallay
- O David
- OJ Shah
- PP Massion
- RC Hresko
- S Kane
- S Ramaswamy
- SK Pal
- SL Cai
- T Mukohara
- TL Yuan
- WT Lim
- YO Al-Bazz
- Publication venue
- Nature Publishing Group
- Publication date
- 19/04/2011
- Field of study
Effectiveness of anodal transcranial direct current stimulation in patients with chronic low back pain: Design, method and protocol for a randomised controlled trial
- Author
- A Antal
- A Valle
- AF Bendix
- AF Mannion
- Alison Rushton
- Arne May
- AS Zigmond
- AV Apkarian
- BW Fenton
- C Ahrens
- C Poreisz
- Christine Wright
- CM Wenig
- D Rasche
- EF Kääpä
- EF Maughan
- F Fregni
- F Fregni
- F Mori
- F Velasco
- G Waddell
- G Waddell
- Gerd Mueller
- GH Guyatt
- H Flor
- H Flor
- H Tsao
- JC Fairbank
- JW Vlaeyen
- K Kumar
- Kerstin Luedtke
- KM Dunn
- M Bullinger
- M Juniper
- M Pfingsten
- MA Nitsche
- MA Nitsche
- MA Nitsche
- MD Soler
- N Dufour
- NE O'Connell
- PC Gandiga
- PM ten Klooster
- PS Boggio
- R Melzack
- R Rodriguez-Raecke
- R Staerkle
- RJ Coffey
- RW Ostelo
- S Bergman
- SE Lamb
- T Kohlmann
- T Schmidt-Wilcke
- T Tsubokawa
- TE Elliott
- Tim P Juergens
- V Exner
- World Medical Association
- Publication venue
- BioMed Central
- Publication date
- 28/12/2011
- Field of study
Multiculturalism and multicultural education approaches to Indigenous people’s education in Taiwan
- Author
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2019
- Field of study
Taiwan has cast multicultural policies as a remedy for inequalities and injustices its 16 Indigenous groups face. Such policies aim to revive Indigenous languages and cultures and create a more welcoming and inclusive environment in schools. Despite the fact that Indigenous people are expected to be primary beneficiaries of these policies, not much is known about how they have affected Indigenous students and communities, if at all. Relying on in-depth semi-structured interviews with 16 Indigenous participants, this paper explores whether the policies have accomplished or are on the way to accomplishing the goals set, as seen by Indigenous people. The findings show that the multicultural approach to education is still informed by assimilationist logic that expects Indigenous people to adjust to the culture and orientations of the dominant group, and as such, does not redress the existing injustices and inequalities
Whole-genome sequencing reveals host factors underlying critical COVID-19
- Author
- Abd Elghafar M. S.
- Abdel-Aziz M.
- Abdelrazik M.
- Abdollahi H.
- Abdullah T.
- Abecasis G. R.
- Abedalthagafi M.
- Abel L.
- Abernathy C.
- Abraheem A.
- Abul-Husn N. S.
- Acquilini D.
- Adams C.
- Adams E. L.
- Adams K.
- Adamsara A.
- Adanini O.
- Adeleye O.
- Adra D.
- Afilalo J.
- Afilalo M.
- Afolabi D.
- Afrasiabi Z.
- Agasou A.
- Agrawal S.
- Aguero D.
- Ahmad N.
- Ahmadi S.
- Ahmed A.
- Ahmed C.
- Akeroyd L.
- Akhtar M. N.
- Akinkugbe O.
- Aksentijevich A.
- Al-Afghani H.
- Al-Awdah L.
- Alaamery M.
- Alahmadey Z. Z.
- Alaverdian D.
- Alavere H.
- Albader A.
- Albaiceta G. M.
- Albakri J. K.
- AlBardis H.
- Albeladi M.
- Albesher N.
- Albrich W.
- AlDhawi N.
- Aldridge J.
- Aleagha A. E.
- Alexander P.
- Alfonso J.
- Alghamdi B.
- Alghamdi J.
- Ali A.
- Ali A.
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- Ali S.
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- Zyndorf M.
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2–4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease
SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues
- Author
- Aarno Palotie
- Abdolmajid Hosseini
- Abdulaziz AlMalik
- Abdulraheem Alshareef
- Achille Iolascon
- Adam S. Butterworth
- Afshar Etemadi Aleagha
- Agnese Verzuri
- Agostino Ognibene
- Agostino Riva
- Ahmadreza Niavarani
- Ahna Girshick
- Aida Fiz-Lopez
- Alba Parra Martınez
- Albandary M. Alowayn
- Albert Tenesa
- Albert V. Smith
- Alessandra Guarnaccia
- Alessandra Renieri
- Alessandra Stella
- Alessandra Vergori
- Alessandro Pancrazzi
- Alessia Giorli
- Alex Serra-Llovich
- Alex Soriano
- Alex Stuckey
- Alexander Labkowsky
- Alexander T. Williams
- Alexander W. Charney
- Alexandra Aksentijevich
- Alexandre Belisle
- Ali Amirsavadkouhi
- Ali Sobh
- Alice Donati
- Alicia de Felipe Mimbrera
- Alicia R. Martin
- Alireza Adamsara
- Altaf Ali
- Amal Al Mutairi
- Amin K. Khattab
- Amr M. Yassen
- Amr Samir
- Amy Trankiem
- Anastasia Lucas
- Andre G. Uitterlinden
- Andrea Antinori
- Andrea Cossarizza
- Andrea Ganna
- Andrea Ganna
- Andrea Martın-Nalda
- Andrea Tommasi
- Andres Metspalu
- Andrew Beck
- Andrew P. Boughton
- Anil P. S. Ori
- Ann E. Woolley
- Anna Canaccini
- Anna Carreras
- Anna Dominguez-Mayoral
- Anna L. Guyatt
- Anna M. Planas
- Anna Maria Pinto
- Annarita Giliberti
- Anne E. Justice
- Anne Kallaste
- Anne Marie O’Connell
- Anne Richmond
- Anne Richmond
- Anne-Sophie Sauvage
- Annique Claringbould
- Anoud Albader
- Antonella D’Arminio Monforte
- Antonella Vincenti
- Antonio Di Biagio
- Antonio Perrella Francesco Bianchi
- Anu Tamm
- Anurag Verma
- Archie Campbell
- Archie Campbell
- Arianna Emiliozzi
- Arianna Gabrieli
- Aris Baras
- Arthur Timothy D
- Asher Haug Baltzell
- Ashish Yadav
- Athanasios Kousathanas
- Attia A. S. Mohamed
- Aubrey Annis
- Augusto Rendon
- Avromie Karp
- Bader Alghamdi
- Bahareh Sharififard
- Bandar A. Suliman
- Barbara Rossetti
- Bari Britvan
- Bartlomiej P. Przychodzen
- Beatriz Cortes
- Beatriz Dietl
- Ben M. Brumpton
- Benjamin M. Neale
- Benoit Misset
- Bernard Lambermont
- Bhavi Trivedi
- Binglan Li
- Biswarup Ghosh
- Bjørn Olav Asvold
- Bluma Brenner
- Brett L. Collins
- Brooke Rhead
- Brooke Wolford
- Brooke Wolford
- Brooke Wolford Sebastian Zo¨ llner
- Bruno Frediani
- Carlo Rivolta
- Carlos Domingo
- Carlota Dobano
- Carmelo Piscopo
- Carmen Marciano
- Carolina Medina-Gomez
- Caroline Cusick
- Caroline Hayward
- Caroline Hayward
- Caterina Lo Rizzo
- Catherine A. Ball
- Catherine E. Bee
- Catherine John
- Cathy Voide
- Cesira Nencioni
- Charlotte Guzman
- Chiara Barbieri
- Chiara Batini
- Chiara Fallerini
- Chiara Gabbi
- Chiara Spertilli
- Chloe Fawns-Ritchie
- Chloe Fawns-Ritchie
- Chris C. A. Spencer
- Chris Tselios
- Christelle Meuris
- Christian Von Frenckell
- Christine Stevens
- Christine Stevens
- Christopher A. Odhams
- Christopher J. Griffiths
- Christopher J. O’Donnell
- Christopher R. Gignoux
- Christos Polymeropoulos
- Chureerat Phokaew
- Claire Churchhouse
- Claudia Suardi
- Claudio Ferri
- Clive Hoggart
- Cotton Seed
- CRiPSI
- Cristen Willer
- Cristina Mussini
- D'Antonio Matteo
- D'Antonio-Chronowska Agnieszka
- Daiana Aguero
- Dan Mason
- Daniel Auld
- Daniel E. Kaufmann
- Daniel I. Chasman
- Daniel J. Wilson
- Daniel King
- Daniel M. Jordan
- Daniel Rader
- Daniel Rhodes
- Daniela Francisci
- Danielle Henry
- Danilo Tacconi
- Danny Park
- Darin Adra
- Dave J. Carey
- David A. van Heel
- David Bennett
- David Bernardo
- David Dalmau
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- Deema AlZahrani
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- Diana Alaverdian
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- Doaa Shahin
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- Donatella Acquilini
- Dorota Pasko
- Douglas M. Shaw
- Duncan Emma
- Duncan S. Palmer
- Ebrahim S. Mahmoud
- Ebtehal Alsolm
- Eco (E. J. C. ) de geus
- Edoardo Conticini
- Edward J. Hollox
- Edward Laane
- Eimear E. Kenny
- Elena Andreucci
- Elena Bargagli
- Elena Desanctis
- Elena Jimenez-Xarrie
- Elena Muino
- Eliecer Coto
- Elisa Arribas
- Elisa Benetti
- Elisa Frullanti
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- Elizabeth W. Karlson
- Eman Barhoush
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- Hakon Hakonarson
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- Hani Al-Afghani
- Hannah Polikowski
- Hanteera S. Moahmed
- Harendra Guturu
- Health Research Team
- Helene Alavere
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- Mattia Cordioli
- Mattia Cordioli
- Mattia Cordioli
- Mattia Cordioli
- Mattia Cordioli
- Mattia Cordioli
- Mattia Cordioli
- Maureen Oliveira
- Maurizio Bussotti
- Maurizio Sanarico
- Maurizio Sanguinetti
- May Alrashed
- Meike Bartels
- Melania Degli Antoni
- Menachem Zlatopolsky
- Meriem Bouab
- Miao Zhang
- Michael Gaddis
- Michael Hultstro¨ m
- Michael N. Cantor
- Michael Peruggia
- Michael Preuss
- Michae¨ l Chasse´
- Michel (M. G. ) Nivard
- Michel Georges
- Michel Moutschen
- Michelle Daya
- Mihael H. Polymeropoulos
- Miklos Lipcsey
- Milos Pavlovic
- Mirella Bruttini
- Miriam Lucia Carriero
- Miriana D’Alessandro
- Mirjam Lista
- Mohamed A. F. Hegazy
- Mohamed R. El-shanshory
- Mohamed S. Abd Elghafar
- Mohamed S. Torky
- Mohammad S. Fawzy
- Mohammed A. Eid
- Mona Sawaji
- Moneera Alswailm
- Monica Poscente
- Monnat Pongpanich
- Monpat Chamnanphon
- Morteza Saeedi
- Nadia Harerimana
- Nardin Rezk Branka Vulesevic
- Natalia Blay
- Natalia Cullell
- Nathalie Brassard
- Nathan Berkowitz
- Nathan Cheng
- Nattiya Hirankarn
- Navya Shilpa Josyula
- Nguyen Jennifer P
- Nicholas Rafaels
- Nick Shrine
- Nicola Picchiotti
- Nicolas Arning
- Nicolas Tardif
- Nicole Soranzo
- Nikolas Baya
- Nils Koelling
- Noam D. Beckmann
- Noemie Boillat
- Noemie Suh
- Nofar Kimchi
- Noor Mamlouk
- Nora Aljawini
- Nouf AlDhawi
- Nour Albesher
- Noura S. Abul-Husn
- Olav Rooyackers
- Olivier Malaise
- Olumide Adeleye
- Opass Putchareon
- Oreste De Vivo
- P-PredictUs SeroCOVID
- Pajaree Chariyavilaskul
- Paloma de la Cal-Sabater
- Paloma Menendez-Valladares
- Pamela Raggi
- Paola Bergomi
- Paola Petrocelli
- Paolo Cameli
- Paolo Di Domenico
- Paolo Piacentini
- Part Peterson
- Pascale Huynen
- Patrick Deelen
- Patrick Turley
- Patrizia Zucchi
- Pattama Torvorapanit
- Paul H. Lee
- Paul M. Ridker
- Paul Naaber
- Paul O’Reilly
- Paul R. H. J. Timmers
- Pauline Lanting
- Per Magnus
- Pere Soler
- Petty E. Lauren
- Phil Tsao
- Philippe Le´ onard
- Pier Giorgio Scotton
- Pierpaolo Parravicini
- Pierre Lepage
- Pierre-Yves Bochud
- Pietro Pinoli
- Pimpayao Sodsai
- Pintip Suchartlikitwong
- Prabhu Arumugam
- Qin Qin Huang
- Rachel G. Liao
- Rafael de Cid
- Raffaele Bruno
- Raffaele Scala
- Raghavendran Partha
- Rahul Gupta
- Raili Allos
- Rana Hasanato
- Rasoul Aliannejad
- Ravaglia Sabrina
- Raymond K. Walters
- Reedik Magi
- Renato Polimanti
- Renzo Scaggiante
- Riccardo Colombo
- Richard C. Trembath
- Richard H. Scott
- Richard J. Packer
- Rita Perna
- Roaa T. Halawani
- Robert C. Free
- Robert C. Green
- Robert Frithiof
- Robert P. Sebra
- Robert Warmerdam
- Roberta Russo
- Roger Colobran
- Ron Do
- Rosangela Artuso
- Rossella Tita
- Rui Li
- Ruth J. F. Loos
- Ryan C. Thompson
- Sabine Claassen
- Sabino Scolletta
- Sabrina Ravaglia
- Saeideh Ahmadi
- Salam Massadeh
- Saleh Alqahtani
- Sam Bryant
- Sam Bryant
- Sam Choi
- Sameer Chavan
- Sameera AlJohani
- Sami Koskelainen
- Samira Azarzar
- Samuli Ripatti
- Sandra P. Smieszek
- Sandro Mancarella
- Sandro Panese
- Sanni Ruotsalainen
- Sara Alotaibi
- Sara Amitrano
- Sara Pigazzini
- Sara Pigazzini
- Sara Pigazzini
- Sara Pigazzini
- Sarah Alkwai
- Sarah Finer
- Sarah G. Earle
- Sauro Luchi
- Saverio Giuseppe Parisi
- Scott T. Weiss
- Sebastian Garcıa Madrona
- Semira Gonseth Nussle
- Serafina Valente
- Serena Ludovisi
- Serghei Mangul
- Sergio Daga
- Seyed Behrooz Mohseni Moghaddam
- Shang-Kuan Lin
- Shannon McCurdy
- Shawn N. Murphy
- Shawneequa Callier
- Shea J. Andrews
- Shea J. Andrews
- Shea J. Andrews
- Shefali S. Verma
- Shona M. Kerr
- Silvia Baroni
- Silvia Cappelli
- Silvia Rojo
- Simona Dei
- Simona Marcantonio
- Simona Sarzi-Braga
- Simone Furini
- Slayton J. Underwood
- Sophie Venturelli
- Souad Rahmouni
- Spencer Knight
- Stefania Mantovani
- Stefano Baratti
- Stefano Busani
- Stefano Ceri
- Stefano Rusconi
- Stephanie Bibert
- Stephen J. Wicks
- Steven Ascolillo
- Ste´ phanie Gofflot
- Stuart C. Sealfon
- Susan Walker
- Susanna Croci
- Susanna Guerrini
- Tala Abdullah
- Tamer A. Elhadidy
- Tess Levy
- Thanyawee Puthanakit
- Thitima B. Suttichet
- Tim D. Spector
- Tiziana Bachetti
- Tom Fowler
- Tomas Segura
- Tomislav Maricic
- Tomoko Nakanishi
- Tomoko Nakanishi
- Tonu Esko
- Tooraj Mirshahi
- Tormod Rogne
- Triin Laisk
- Tullio Trotta
- Valentina Anemoli
- Vasilios Polymeropoulos
- Veronica Rico
- Veronica Robles
- Ve´ronique Erard
- Victor Moreno
- Vincent Mooser
- Vincenzo Forgetta
- Vincenzo Forgetta
- Voraphoj Nilaratanakul
- Vorasuk Shotelersuk
- Walaa A. Felemban
- Walaa M. El-Lawaty
- Walid T. Khafaga
- Wanna Chetruengchai
- Watsamon Jantarabenjakul
- Wei Zhou
- Wei Zhou
- Wenhan Lu
- Werner Albrich
- Xavier Farre
- Xiao Chang
- Xiao Chang
- Xiaoqing Xue
- Xueyang Wang
- Yan V. Sun
- Yaseen M. Arabi
- Yasmine Belhaj
- Yasser M. El-Sherbiny
- Yen-Chen Anne Feng
- Yuk-Lam Ho
- Yuki Bradford
- Yunsung Lee
- Yuval Itan
- Yves Beguin
- Zaman Afrasiabi
- Zeinab Naderpour
- Zhu Wanying
- Ziab Z. Alahmadey
- Øyvind Helgeland
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2022
- Field of study
Variability in SARS-CoV-2 susceptibility and COVID-19 disease severity between individuals is partly due to
genetic factors. Here, we identify 4 genomic loci with suggestive associations for SARS-CoV-2 susceptibility
and 19 for COVID-19 disease severity. Four of these 23 loci likely have an ethnicity-specific component.
Genome-wide association study (GWAS) signals in 11 loci colocalize with expression quantitative trait loci
(eQTLs) associated with the expression of 20 genes in 62 tissues/cell types (range: 1:43 tissues/gene),
including lung, brain, heart, muscle, and skin as well as the digestive system and immune system. We perform
genetic fine mapping to compute 99% credible SNP sets, which identify 10 GWAS loci that have eight or fewer
SNPs in the credible set, including three loci with one single likely causal SNP. Our study suggests that the
diverse symptoms and disease severity of COVID-19 observed between individuals is associated with variants across the genome, affecting gene expression levels in a wide variety of tissue types
Rising rural body-mass index is the main driver of the global obesity epidemic in adults
- Author
- Abarca-Gomez Leandra
- Abdeen Ziad A.
- Abdrakhmanova Shynar
- Abu-Rmeileh Niveen M.
- Acosta-Cazares Benjamin
- Adams Robert J.
- Aekplakorn Wichai
- Afsana Kaosar
- Agdeppa Imelda A.
- Aguilar-Salinas Carlos A.
- Agyemang Charles
- Ahmad Mohamad Hasnan
- Ahmad Noor Ani
- Ahmadi Naser
- Ahmadvand Alireza
- Ahrens Wolfgang
- Ajlouni Kamel
- Al Nsour Mohannad
- Al-Hazzaa Hazzaa M.
- Al-Othman Amani Rashed
- Al-Raddadi Rajaa
- AlBuhairan Fadia
- AlDhukair Shahla
- Ali Mohamed M.
- Ali Osman
- Alkerwi Ala'a
- Alvarez-Pedrerol Mar
- Aly Eman
- Amarapurkar Deepak N.
- Amouyel Philippe
- Amuzu Antoinette
- Anderssen Sigmund A.
- Angquist Lars H.
- Anjana Ranjit Mohan
- Ansari-Moghaddam Alireza
- Anselmo Olinto Maria Teresa
- Aounallah-Skhiri Hajer
- Araujo Joana
- Ariansen Inger
- Aris Tahir
- Arku Raphael E.
- Arlappa Nimmathota
- Aryal Krishna K.
- Aspelund Thor
- Assah Felix K.
- Assuncao Maria Cecilia F.
- Aung May Soe
- Auvinen Juha
- Avdicova Maria
- Azevedo Ana
- Azizi Fereidoun
- Azmin Mehrdad
- Babu Bontha V.
- Baharudin Azli
- Bahijri Suhad
- Baker Jennifer L.
- Balakrishna Nagalla
- Bamoshmoosh Mohamed
- Banach Maciej
- Bandosz Piotr
- Banegas Jose R.
- Barbagallo Carlo M.
- Barcelo Alberto
- Barkat Amina
- Barros Aluisio J. D.
- Barros Mauro V. G.
- Bata Iqbal
- Batieha Anwar M.
- Batista Rosangela L.
- Battakova Zhamilya
- Batyrbek Assembekov
- Baur Louise A.
- Beaglehole Robert
- Bebakar Wan Mohamad Wan
- Bel-Serrat Silvia
- Ben Romdhane Habiba
- Benedics Judith
- Benet Mikhail
- Bennett James E.
- Bentham James
- Berkinbayev Salim
- Bernabe-Ortiz Antonio
- Bernotiene Gailute
- Bettiol Heloisa
- Bhagyalaxmi Aroor
- Bharadwaj Sumit
- Bhargava Santosh K.
- Bhutta Zulfiqar A.
- Bi Hongsheng
- Bi Yufang
- Biehl Anna
- Bikbov Mukharram
- Bista Bihungum
- Bixby Honor
- Bjelica Dusko J.
- Bjerregaard Peter
- Bjertness Espen
- Bjertness Marius B.
- Bjorkelund Cecilia
- Blokstra Anneke
- Bo Lars
- Bo Simona
- Bobak Martin
- Boddy Lynne M.
- Boehm Bernhard O.
- Boeing Heiner
- Boggia Jose G.
- Boissonnet Carlos P.
- Bonaccio Marialaura
- Bongard Vanina
- Bopp Matthias
- Borchini Rossana
- Borghs Herman
- Bovet Pascal
- Braeckevelt Lien
- Braeckman Lutgart
- Bragt Marjolijn C. E.
- Brajkovich Imperia
- Branca Francesco
- Braunerova Radka Taxova
- Breckenkamp Jürgen
- Breda Joao
- Brenner Hermann
- Brewster Lizzy M.
- Brian Garry R.
- Brinduse Lacramioara
- Bruno Graziella
- Bueno-de-Mesquita H. Bas
- Bugge Anna
- Buoncristiano Marta
- Burazeri Genc
- Burns Con
- Cabrera de Leon Antonio
- Cacciottolo Joseph
- Cai Hui
- Cama Tilema
- Cameron Christine
- Camolas Jose
- Can Gamze
- Can Gunay
- Candido Ana Paula C.
- Canete Felicia
- Capanzana Mario V.
- Capuano Eduardo
- Capuano Vincenzo
- Cardoso Viviane C.
- Carlsson Axel C.
- Carmuega Esteban
- Carrillo-Larco Rodrigo M.
- Carvalho Maria J.
- Casanueva Felipe F.
- Casas Juan-Pablo
- Caserta Carmelo A.
- Celikcan Ertugrul
- Censi Laura
- Cesar Juraci A.
- Chamukuttan Snehalatha
- Chan Angelique W.
- Chan Queenie
- Chaturvedi Himanshu K.
- Chaturvedi Nishi
- Chen Chien-Jen
- Chen Fangfang
- Chen Huashuai
- Chen Shuohua
- Chen Zhengming
- Cheng Ching-Yu
- Cheng Yiling J.
- Chetrit Angela
- Chikova-Iscener Ekaterina
- Chinh Nguyen Huu Chinh Nguyen Huu
- Chiolero Arnaud
- Chiou Shu-Ti
- Chirita-Emandi Adela
- Chirlaque Maria-Dolores
- Cho Belong
- Cho Yumi
- Christensen Kaare
- Christofaro Diego G.
- Chudek Jerzy
- Cifkova Renata
- Cilia Michelle
- Cinteza Eliza
- Claessens Frank
- Clarke Janine
- Clays Els
- Concin Hans
- Confortin Susana C.
- Cooper Cyrus
- Coppinger Tara C.
- Costanzo Simona
- Cottel Dominique
- Cowan Melanie J.
- Cowell Chris
- Craig Cora L.
- Crampin Amelia C.
- Crujeiras Ana B.
- Cruz Juan J.
- Cucu Alexandra
- Cui Liufu
- D'Arrigo Graziella
- d'Orsi Eleonora
- Dallongeville Jean
- Damasceno Albertino
- Damsgaard Camilla T.
- Danaei Goodarz
- Dankner Rachel
- Dantoft Thomas M.
- Dasgupta Parasmani
- Dastgiri Saeed
- Dauchet Luc
- Davletov Kairat
- De Backer Guy
- De Bacquer Dirk
- De Curtis Amalia
- de Gaetano Giovanni
- De Henauw Stefaan
- de Oliveira Paula Duarte
- De Ridder Karin
- de Rooij Susanne R.
- De Smedt Delphine
- de Wit Tobias F. Rinke
- Deepa Mohan
- Deev Alexander D.
- Dehghan Abbas
- del Cristo Rodriguez-Perez Maria
- Delisle Helene
- Delpeuch Francis
- Dennison Elaine
- Deschamps Valerie
- Dhana Klodian
- Dhimal Meghnath
- Di Castelnuovo Augusto F.
- Di Cesare Mariachiara
- Dias-da-Costa Juvenal Soares
- Diaz Alejandro
- Dika Zivka
- Djalalinia Shirin
- Do Ha T. P.
- Dobson Annette J.
- Doering Angela
- Donati Maria Benedetta
- Donfrancesco Chiara
- Donoso Silvana P.
- Dorobantu Maria
- Dorosty Ahmad Reza
- Doua Kouamelan
- Drygas Wojciech
- Duan Jia Li
- Duante Charmaine A.
- Duda Rosemary B.
- Duleva Vesselka
- Dulskiene Virginija
- Dumith Samuel C.
- Dzerve Vilnis
- Dziankowska-Zaborszczyk Elzbieta
- Eddie Ricky
- Egbagbe Eruke E.
- Eggertsen Robert
- Eiben Gabriele
- Ekelund Ulf
- El Ati Jalila
- Eldemire-Shearer Denise
- Eliasen Marie
- Elliott Paul
- Engle-Stone Reina
- Erasmus Rajiv T.
- Erem Cihangir
- Eriksen Louise
- Eriksson Johan G.
- Escobedo-de la Pena Jorge
- Evans Alun
- Ezzati Majid
- Faeh David
- Fall Caroline H.
- Farzadfar Farshad
- Fattahi Mohammad R.
- Felix-Redondo Francisco J.
- Ferguson Trevor S.
- Fernandes Romulo A.
- Fernandez-Berges Daniel
- Ferrante Daniel
- Ferrari Marika
- Ferreccio Catterina
- Ferrer Eldridge
- Ferrieres Jean
- Fijalkowska Anna
- Fink Gunther
- Fischer Krista
- Flores Eric Monterubio
- Foeger Bernhard
- Foo Leng Huat
- Forslund Ann-Sofie
- Forsner Maria
- Fouad Heba M.
- Francis Damian K.
- Francisco Miquel Juan
- Franco Maria do Carmo
- Franco Oscar H.
- Frontera Guillermo
- Fuchs Flavio D.
- Fuchs Sandra C.
- Fujita Yuki
- Furusawa Takuro
- Gaciong Zbigniew
- Gafencu Mihai
- Galeone Daniela
- Galvano Fabio
- Gao Jingli
- Garba Jamila Abubakar
- Garcia-de-la-Hera Manoli
- Gareta Dickman
- Garnett Sarah P.
- Gaspoz Jean-Michel
- Gasull Magda
- Gates Louise
- Gazzinelli Andrea
- Geiger Harald
- Geleijnse Johanna M.
- Ghaffar Suhaila Abdul
- Ghanbari Ali
- Ghasemi Erfan
- Ghasemian Anoosheh
- Gheorghe-Fronea Oana-Florentina
- Giampaoli Simona
- Gianfagna Francesco
- Gill Tiffany K.
- Giovannelli Jonathan
- Gironella Glen
- Giwercman Aleksander
- Godos Justyna
- Gogen Sibel
- Goldsmith Rebecca A.
- Goltzman David
- Goncalves Helen
- Gonzalez Angel R.
- Gonzalez-Chica David A.
- Gonzalez-Gross Marcela
- Gonzalez-Leon Margot
- Gonzalez-Rivas Juan P.
- Gonzalez-Villalpando Maria-Elena
- Gottrand Frederic
- Graca Antonio Pedro
- Graff-Iversen Sidsel
- Grafnetter Dusan
- Grajda Aneta
- Grammatikopoulou Maria G.
- Gregg Edward W.
- Gregor Ronald D.
- Grodzicki Tomasz
- Grontved Anders
- Grosso Giuseppe
- Gruden Gabriella
- Gu Dongfeng
- Gualdi-Russo Emanuela
- Gudmundsson Elias F.
- Gudnason Vilmundur
- Guerrero Ramiro
- Guessous Idris
- Guimaraes Andre L.
- Gulliford Martin C.
- Gunnlaugsdottir Johanna
- Gunter Marc
- Guo Xiuhua
- Guo Yin
- Gupta Prakash C.
- Gupta Rajeev
- Gureje Oye
- Gurzkowska Beata
- Gutierrez Laura
- Gutzwiller Felix
- Hadaegh Farzad
- Hadjigeorgiou Charalambos A.
- Haghshenas Rosa
- Halkjaer Jytte
- Hambleton Ian R.
- Hamid Zargar Abdul
- Hardy Rebecca
- Hassapidou Maria
- Hata Jun
- Haugsgjerd Teresa
- Hayes Alison J.
- He Jiang
- He Yuna
- Heidinger-Felso Regina
- Heinen Mirjam
- Hejgaard Tatjana
- Hendriks Marleen Elisabeth
- Henriques Ana
- Hernandez Cadena Leticia
- Herrala Sauli
- Herrera Victor M.
- Herter-Aeberli Isabelle
- Heshmat Ramin
- Hill Allan G.
- Ho Sai Yin
- Ho Suzanne C.
- Hobbs Michael
- Hofman Albert
- Hopman Wilma M.
- Horimoto Andrea R. V. R.
- Hormiga Claudia M.
- Horta Bernardo L.
- Houti Leila
- Howitt Christina
- Htay Thein Thein
- Htet Aung Soe
- Htike Maung Maung Than
- Hu Yonghua
- Huerta Jose Maria
- Huhtaniemi Ilpo Tapani
- Huisman Martijn
- Husseini Abdullatif
- Huybrechts Inge
- Hwalla Nahla
- Hyska Jolanda
- Iacoviello Licia
- Ibarluzea Jesus M.
- Ibrahim Mohsen M.
- Ikeda Nayu
- Ikram M. Arfan
- Ioannidou Eliza Markidou
- Irazola Vilma E.
- Ishida Takafumi
- Islam Muhammad
- Ismail Aziz al-Safi
- Iurilli Maria L. C.
- Ivkovic Vanja
- Iwasaki Masanori
- Jaaskelainen Tuija
- Jackson Rod T.
- Jacobs Jeremy M.
- Jaddou Hashem
- Jafar Tazeen
- James Kenneth
- Jamil Kazi M.
- Jamrozik Konrad
- Janszky Imre
- Janus Edward
- Jarani Juel
- Jarvelin Marjo-Riitta
- Jasienska Grazyna
- Jelakovic Ana
- Jelakovic Bojan
- Jennings Garry
- Jeong Seung-Lyeal
- Jerome Charles Sossa
- Jiang Chao Qiang
- Jimenez Ramon O.
- Joffres Michel
- Johansson Mattias
- Jokelainen Jari J.
- Jonas Jost B.
- Jorgensen Torben
- Joshi Pradeep
- Jovic Dragana P.
- Jozwiak Jacek
- Juolevi Anne
- Jurak Gregor
- Juresa Vesna
- Kaaks Rudolf
- Kafatos Anthony
- Kajantie Eero O.
- Kalter-Leibovici Ofra
- Kamaruddin Nor Azmi
- Kameli Yves
- Kapantais Efthymios
- Karki Khem B.
- Kasaeian Amir
- Katibeh Marzieh
- Katz Joanne
- Katzmarzyk Peter T.
- Kauhanen Jussi
- Kaur Prabhdeep
- Kavousi Maryam
- Kazakbaeva Gyulli
- Keil Ulrich
- Keinan-Boker Lital
- Keinanen-Kiukaanniemi Sirkka
- Kelishadi Roya
- Kelleher Cecily
- Kemper Han C. G.
- Kengne Andre P.
- Kerimkulova Alina
- Kersting Mathilde
- Key Timothy
- Khader Yousef Saleh
- Khalili Davood
- Khang Young-Ho
- Khanh Le Nguyen Bao Khanh Le Nguyen Bao
- Khateeb Mohammad
- Khaw Kay-Tee
- Kheiri Bahareh
- Khosravi Alireza
- Khouw Ilse M. S. L.
- Kiechl Stefan
- Kiechl-Kohlendorfer Ursula
- Killewo Japhet
- Kim Jeongseon
- Kim Yeon-Yong
- Klimont Jeannette
- Klumbiene Jurate
- Knoflach Michael
- Koenig Jurgen
- Koirala Bhawesh
- Kolle Elin
- Kolsteren Patrick
- Korpelainen Raija
- Korrovits Paul
- Korzycka Magdalena
- Koskinen Seppo
- Kouda Katsuyasu
- Kovacs Viktoria A.
- Kowlessur Sudhir
- Koziel Slawomir
- Kratzer Wolfgang
- Kriemler Susi
- Kristensen Peter Lund
- Krokstad Steinar
- Kromhout Daan
- Kruger Herculina S.
- Kubinova Ruzena
- Kuciene Renata
- Kuh Diana
- Kujala Urho M.
- Kujundzic Enisa
- Kulaga Zbigniew
- Kumar R. Krishna
- Kumar Rachakulla Hari
- Kunesova Marie
- Kurjata Pawel
- Kusuma Yadlapalli S.
- Kuulasmaa Kari
- Kyobutungi Catherine
- Laamiri Fatima Zahra
- Laatikainen Tiina
- Lachat Carl
- Laid Youcef
- Lanska Vera
- Lappas Georg
- Larijani Bagher
- Latt Tint Swe
- Laugsand Lars E.
- Lauria Laura
- Laxmaiah Avula
- Lazo-Porras Maria
- Le Port Agnes
- Le Tuyen D.
- Lee Jeannette
- Lee Jeonghee
- Lee Paul H.
- Lehtimaki Terho
- Lele Elysee Claude Bika
- Lemogoum Daniel
- Levitt Naomi S.
- Li Yanping
- Lilly Christa L.
- Lim Wei-Yen
- Lima-Costa M. Fernanda
- Lin Hsien-Ho
- Lin Xu
- Lind Lars
- Linneberg Allan
- Lissner Lauren
- Litwin Mieczyslaw
- Liu Jing
- Loit Helle-Mai
- Lopes Luis
- Lopez Tania
- Lopez-Garcia Esther
- Lorbeer Roberto
- Lotufo Paulo A.
- Lozano Jose Eugenio
- Luksiene Dalia
- Lundqvist Annamari
- Lundqvist Robert
- Lunet Nuno
- Lytsy Per
- Ma Guansheng
- Ma Jun
- Machado-Coelho George L. L.
- Machado-Rodrigues Aristides M.
- Machi Suka
- Maggi Stefania
- Magliano Dianna J.
- Magriplis Emmanuella
- Maire Bernard
- Majer Marjeta
- Makdisse Marcia
- Malekzadeh Fatemeh
- Malekzadeh Reza
- Malhotra Rahul
- Malyutina Sofia
- Maniego Lynell V.
- Manios Yannis
- Mann Jim I.
- Manzato Enzo
- Margozzini Paula
- Markaki Anastasia
- Markey Oonagh
- Marques Larissa Pruner
- Marques-Vidal Pedro
- Marrugat Jaume
- Martin Rosemarie
- Martin-Prevel Yves
- Martorell Reynaldo
- Martos Eva
- Marventano Stefano
- Masoodi Shariq R.
- Mathiesen Ellisiv B.
- Mathur Prashant
- Matijasevich Alicia
- Matsha Tandi E.
- Mazur Artur
- Mbanya Jean Claude N.
- McFarlane Shelly R.
- McGarvey Stephen T.
- Mckee Martin
- McLachlan Stela
- McLean Rachael M.
- McLean Scott B.
- McNulty Breige A.
- Mediene-Benchekor Sounnia
- Medzioniene Jurate
- Mehdipour Parinaz
- Meirhaeghe Aline
- Meisfjord Jorgen
- Meisinger Christa
- Menezes Ana Maria B.
- Menon Geetha R.
- Mensink Gert B. M.
- Mereke Alibek
- Meshram Indrapal I.
- Metspalu Andres
- Meyer Haakon E.
- Mi Jie
- Michaelsen Kim F.
- Michels Nathalie
- Mikkel Kairit
- Milanovic Sanja Music
- Miller Jody C.
- Minderico Claudia S.
- Minh Hoang Van
- Miranda J. Jaime
- Mirkopoulou Daphne
- Mirrakhimov Erkin
- Misigoj-Durakovic Marjeta
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- Walton Janette
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- Wang Qian
- Wang Xiangjun
- Wang Ya Xing
- Wang Ying-Wei
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- Weerasekera Deepa
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- Wu Jianfeng
- Wu Shouling
- Xu Haiquan
- Xu Liang
- Yamborisut Uruwan
- Yan Weili
- Yang Ling
- Yang Xiaoguang
- Yang Yang
- Yardim Nazan
- Yaseri Mehdi
- Ye Xingwang
- Yiallouros Panayiotis K.
- Yngve Agneta
- Yoosefi Moein
- Yoshihara Akihiro
- You Qi Sheng
- You San-Lin
- Younger-Coleman Novie O.
- Yusof Safiah Md
- Yusoff Ahmad Faudzi
- Yusoff Muhammad Fadhli Mohd
- Zaccagni Luciana
- Zafiropulos Vassilis
- Zainuddin Ahmad A.
- Zamani Farhad
- Zambon Sabina
- Zampelas Antonis
- Zamrazilova Hana
- Zapata Maria Elisa
- Zaw Ko Ko
- Zdrojewski Tomasz
- Zeng Yi
- Zhao Dong
- Zhao Wenhua
- Zheng Wei
- Zheng Yingfeng
- Zholdin Bekbolat
- Zhou Bin
- Zhou Maigeng
- Zhu Dan
- Zhussupov Baurzhan
- Zimmermann Esther
- Zuniga Cisneros Julio
- Publication venue
- Publication date
- 01/01/2019
- Field of study
Body-mass index (BMI) has increased steadily in most countries in parallel with a rise in the proportion of the population who live in cities(.)(1,2) This has led to a widely reported view that urbanization is one of the most important drivers of the global rise in obesity(3-6). Here we use 2,009 population-based studies, with measurements of height and weight in more than 112 million adults, to report national, regional and global trends in mean BMI segregated by place of residence (a rural or urban area) from 1985 to 2017. We show that, contrary to the dominant paradigm, more than 55% of the global rise in mean BMI from 1985 to 2017-and more than 80% in some low- and middle-income regions-was due to increases in BMI in rural areas. This large contribution stems from the fact that, with the exception of women in sub-Saharan Africa, BMI is increasing at the same rate or faster in rural areas than in cities in low- and middle-income regions. These trends have in turn resulted in a closing-and in some countries reversal-of the gap in BMI between urban and rural areas in low- and middle-income countries, especially for women. In high-income and industrialized countries, we noted a persistently higher rural BMI, especially for women. There is an urgent need for an integrated approach to rural nutrition that enhances financial and physical access to healthy foods, to avoid replacing the rural undernutrition disadvantage in poor countries with a more general malnutrition disadvantage that entails excessive consumption of low-quality calories.Peer reviewe
Whole-genome sequencing reveals host factors underlying critical COVID-19
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- Zyndorf M.
- Zöllner S.
- Åsvold B.O.
- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 07/07/2022
- Field of study
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease
A first update on mapping the human genetic architecture of COVID-19
- Author
- Abd Elghafar Mohamed S.
- Abdel-Aziz Mahmoud
- Abdollahi Hamed
- Abdullah Tala
- Abecasis Goncalo R.
- Abedalthagafi Malak
- Abul-Husn Noura S.
- Acquilini Donatella
- Adams Emma L.
- Adamsara Alireza
- Adeleye Olumide
- Adra Darin
- Afilalo Jonathan
- Afilalo Marc
- Afrasiabi Zaman
- Agüero Daiana
- Ahmadi Saeideh
- Akhtar Shaheen
- Aksentijevich Alexandra
- Al-Afghani Hani
- Al-Awdah Laila
- Alaamery Manal
- Alahmadey Ziab Z.
- Alaverdian Diana
- Alavere Helene
- Albader Anoud
- Albaiceta Guillermo M.
- Albakri Jehad K.
- AlBardis Hadeel
- Albeladi Maha
- Albesher Nour
- Albrich W. C.
- Albrich Werner
- AlDhawi Nouf
- Aleagha Afshar Etemadi
- Alghamdi Bader
- Alghamdi Jahad
- Ali Altaf
- Aliannejad Rasoul
- Aljawini Nora
- AlJohani Sameera
- Alkwai Sarah
- Allos Raili
- AlMalik Abdulaziz
- Almalki Faisal
- Almohammed Iman
- Almutairi Mansour
- Alotaibi Sara
- Alowayn Albandary M.
- Alqahtani Saleh
- Alqubaishi Fatimah
- Alrashed May
- Alshareef Abdulraheem
- Alsolm Ebtehal
- Alswailm Moneera
- AlZahrani Deema
- Amirsavadkouhi Ali
- Amitrano Sara
- Andolfo Immacolata
- Andretta Francesca
- Andreucci Elena
- Andrews Shea J.
- Anedda Federico
- Anemoli Valentina
- Angelantonio Emanuele Di
- Annis Aubrey
- Antinori Andrea
- Antoni Melania Degli
- Anwar Mohammad
- Arabi Yaseen M.
- Arciero Elena
- Armstrong Jacob
- Arning Nicolas
- Arranz Maria J.
- Arribas Elisa
- Artuso Rosangela
- Arumugam Prabhu
- Ascolillo Steven
- Ashraf Samina
- Atkinson Elizabeth G.
- Aucella Filippo
- Auld Daniel
- AZARZAR Samira
- Bachetti Tiziana
- Baillie J. Kenneth
- Balaconis Mary K.
- Baldassarri Margherita
- Ball Catherine A.
- Baltzell Asher Haug
- Band Gavin
- Bandini Maria
- Baraka Dona
- Baras Aris
- Baratti Stefano
- Barbieri Chiara
- Barda B.
- Bargagli Elena
- Barhoush Eman
- Barnes Kathleen C.
- Baroni Silvia
- Bartels Meike
- Bassetti Matteo
- Batini Chiara
- Baya Nikolas
- Beck Andrew
- Beckmann Noam D.
- Bedini Josep L.
- Bee Catherine E.
- Beguin Yves
- Belbin Gillian M.
- Belhaj Yasmine
- Beligni Giada
- Belisle Alexandre
- Belli Mary Ann
- Below Jennifer
- Benetti Elisa
- Bennett David
- Bergantini Laura
- Bergomi Paola
- Berkowitz Nathan
- Bernardo David
- Biagio Antonio Di
- Bianchi Francesco
- Bibert Stéphanie
- Bibert Stéphanie
- Biesecker Les
- Biscarini Filippo
- Blay Natalia
- Bochud M.
- Bochud P. Y.
- Bochud P. Y.
- Bochud Pierre-Yves
- Bochud Pierre-Yves
- Boezen Marike
- Boillat Noémie
- Boillat-Blanco N.
- Bottà Giordano
- Bouab Meriem
- Boughton Andrew P.
- Bouras K.
- Bradford Yuki
- Brahier T.
- Brassard Nathalie
- Breen Gerome
- Brenner Bluma
- Britvan Bari
- Brumpton Ben M.
- Bruno Raffaele
- Bruttini Mirella
- Bryant Sam
- Bryant Sam
- Buring Julie E.
- Busani Stefano
- Bussotti Maurizio
- Butler-Laporte Guillaume
- Butterworth Adam S.
- Buxbaum Joseph D.
- Caldarelli Gian Piero
- Callier Shawneequa
- Cameli Paolo
- Campbell Archie
- Campbell Archie
- Canaccini Anna
- Cantarini Luca
- Cantor Michael N.
- Capasso Mario
- Capitani Katia
- Cappelli Silvia
- Carella Massimo
- Carey Dave J.
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- Carriero Miriam Lucia
- Castaño-Vinyals Gemma
- Castelli Francesco
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- Cho Judy H.
- Cho Kelly
- Choi Sam
- Chowdhury Maharun
- Chung Raymond
- Churchhouse Claire
- Chwialkowska Karolina
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- Claringbould Annique
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- Conen A.
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- Daya Michelle
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- Dobaño Carlota
- Doddato Gabriella
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- Domingo Carlos
- Domínguez-Mayoral Anna
- Donati Alice
- Donner Kati
- Durand Madeleine
- Durham Ceri
- D’Acremont V.
- D’Alessandro Miriana
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- Emiliozzi Arianna
- Emma Duncan
- Erard Véronique
- Erard Véronique
- Esko Tõnu
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- Fabbiani Massimiliano
- Falcone Marco
- Fallerini Chiara
- Farré Xavier
- Fava Francesca
- Fawns-Ritchie Chloe
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- Finucane Hilary
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- Franchi Federico
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- Friolet R.
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- Frithiof Robert
- Frullanti Elisa
- Furini Simone
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- Gabrieli Arianna
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- García-Clemente Marta
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- Gatti Francesca
- Gaziano J. Michael
- Georges Michel
- Gettler Kyle
- Ghosh Biswarup
- Giannattasio Ferdinando
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- Giliberti Annarita
- Giorli Alessia
- Giot Jean-Baptiste
- Girardis Massimo
- Girshick Ahna
- Glessner Joseph R.
- Glessner Joseph T.
- Gofflot Stéphanie
- Goldstein Jacqueline I.
- Gomez Juan
- Gonseth Nussle S.
- González-Villa Esther
- Gori Marco
- Grassi Davide
- Green Robert C.
- Griffiths Chris
- Griffiths Christopher J.
- Grip Jonathan
- Guarnaccia Alessandra
- Guerrini Susanna
- Guidelli Luca
- Guillet A.
- Guindo-Martinez Marta
- Guiot Julien
- Guntz Julien
- Gupta Rahul
- Guturu Harendra
- Guyat-Jacques C.
- Guyatt Anna L.
- Guzman Charlotte
- Guéry B.
- Haefliger D.
- Hakonarson Hakon
- Hakonarson Hakon
- Halawani Roaa T.
- Harerimana Nadia
- Harris Jennifer R.
- Harthi Fawz Al
- Hasanato Rana
- Hayward Caroline
- Hayward Caroline
- Hegazy Mohamed A. F.
- Helgeland Øyvind
- Henry Danielle
- Hensen Kati
- Hiester Liam L.
- Hirankarn Nattiya
- Ho Yuk-Lam
- Hoggart Clive
- Hollox Edward J.
- Hong Eurie L.
- Horowitz Julie E.
- Hosseini Abdolmajid
- Hottenga Jouke Jan
- Huang Qin Qin
- Huang Qin Qin
- Huckins Laura M.
- Huffman Jennifer E.
- Hultström Michael
- Hunt Karen A.
- Hunt Karen A.
- Hurles Matt
- Hussain Shapna
- Huynen Pascale
- Hveem Kristian
- Hügli O.
- Iglesias Lara Lloret
- Ikram M. Arfan
- Iolascon Achille
- Islam Kamrul
- Itan Yuval
- Jacques Jessica
- Jantarabenjakul Watsamon
- Jaquet M.
- Jiménez-Xarrié Elena
- John Catherine
- Jordan Daniel M.
- Josyula Navya Shilpa
- Jung Junghyun
- Justice Anne E.
- Kahlert C. R.
- Kallaste Anne
- Kamdar Dhryata
- Kamdar Dhryata
- Kampouri E. E.
- Kanai Masahiro
- Kanai Masahiro
- Karczewski Konrad J.
- Karjalainen Juha
- Karlson Elizabeth W.
- Karp Avromie
- Kaufmann Daniel E.
- Kaunisto Mari
- Keller Katherine
- Kenny Eimear E.
- Kerchberger V. Eric
- Kerr Shona M.
- Khafaga Walid T.
- Khan Ahsan
- Khan Amara
- Khattab Amin K.
- Kimchi Nofar
- King Daniel
- Kisand Kai
- Kivinen Katja
- Kleger G-R.
- Knapp C.
- Knight Spencer
- Koelling Nils
- Kogevinas Manolis
- Koskelainen Sami
- Kosmicki Jack A.
- Kousathanas Athanasios
- Kristiansson Kati
- Laane Edward
- Labkowsky Alexander
- Laisk Triin
- Lambermont Bernard
- Lannepoudenx Y.
- Lanting Pauline
- Lathrop G. Mark
- Lauren Petty E.
- Laurent Laetitia
- Lavery Cath
- Leader Joseph B.
- Lee Paul H.
- Lee Sang Hyuck
- Lee Sulggi
- Lee Yunsung
- LeFaive Jonathon
- Lena Fabio
- Lepage Pierre
- Lepamets Maarja
- Lerner Robin
- Levy Tess
- Li Binglan
- Li Kevin W.
- Li Rui
- Liao Rachel G.
- Lin Shang-Kuan
- Lipcsey Miklos
- Lista Mirjam
- Llucià-Carol Laia
- Loos Ruth J. F.
- Lopera Esteban
- Lorubbio Maria
- Lozano Francisco
- Lu Wenhan
- Lucas Anastasia
- Luchi Sauro
- Ludovisi Serena
- Läll Kristi
- Léonard Philippe
- MacArthur Daniel
- MacLaughlin Bev
- Maggiolo Franco
- Magnus Per
- Mahmoud Ebrahim S.
- Malaise Olivier
- Mamlouk Noor
- Mancarella Sandro
- Mandalà Marco
- Mangino Massimo
- Mangul Serghei
- Manson JoAnn E.
- Mantovani Stefania
- Manuel O.
- Marcantonio Simona
- MARCHETTI Oreste
- Marciano Carmen
- Mari Francesca
- Maricic Tomislav
- Martin Alicia R.
- Martin Hilary
- Martin Hilary C.
- Martinelli Enrico
- Martí-Fàbregas Joan
- Martín-Nalda Andrea
- Martínez Alba Parra
- Masjuan Jaime
- Mason Dan
- Mason Dan
- Massadeh Salam
- Masucci Luca
- Mazzei Maria Antonietta
- McCormick Joseph B.
- McCurdy Shannon
- Medina-Gomez Carolina
- Meigs James B.
- Meloni Ilaria
- Menatti Elisabetta
- Mencarelli Maria Antonietta
- Menéndez-Valladares Paloma
- Mercader Josep
- Mercader Josep Maria
- Merla Giuseppe
- Metsalu Kristjan
- Metspalu Andres
- Meuris Christelle
- Meuwly J. Y.
- Miah Shefa
- Milani Lili
- Miraglia Federica Gaia
- Mirshahi Tooraj
- Misset Benoît
- Moahmed Hanteera S.
- Moghaddam Seyed Behrooz Mohseni
- Mohamed Attia A. S.
- Mondelli Mario Umberto
- Monica Matteo Della
- Montagnani Francesca
- Montillier P.
- Mooser Vincent
- Moreno Victor
- Morris Marcela
- Morrison David R.
- Moutschen Michel
- Moutsianas Loukas
- Muiño Elena
- Munting A.
- Murphy Shawn N.
- Mussini Cristina
- Mutairi Amal Al
- Márquez Leonardo
- Mägi Reedik
- Naaber Paul
- Naderpour Zeinab
- Nadkarni Girish N.
- Nakanishi Tomoko
- Neale Benjamin M.
- Neale Benjamin M.
- Negro T. Rochat
- Nencioni Cesira
- Neofytos Dionysios
- Neofytos Dionysios
- Newman Bill
- Nguyen Huy
- Niavarani Ahmadreza
- Niblo Kristi
- Niemi Mari E. K.
- Nilaratanakul Voraphoj
- Nivard Michel M. G.
- Nkambul Lindo
- Nkambul Lindokuhle
- Nkambule Lindokuhle
- Nkambule Lindokuhle
- North Kari
- Noto Keith
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- Odhams Christopher A.
- Ognibene Agostino
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- Oliveira Maureen
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- Parati Gianfranco
- Parisi Saverio Giuseppe
- Park Danny
- Parravicini Pierpaolo
- Partha Raghavendran
- Pasko Dorota
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- Pavlovic Milos
- Peloso Gina
- Perez Emma F.
- Perez-Tur Jordi
- Perna Rita
- Perola Markus
- Perrella Antonio
- Perret A.
- Peruggia Michael
- Pessina Gloria
- Pesukova Jaana
- Peterson Pärt
- Petitjean Louis
- Petrocelli Paola
- Phokaew Chureerat
- Piacentini Paolo
- Picchiotti Nicola
- Pietro Massimo Di
- Pigazzini Sara
- Pinoli Pietro
- Pinto Anna Maria
- Pirinen Matti
- Piscopo Carmelo
- Planas Anna M.
- Polikowski Hannah
- Polimanti Renato
- Polymeropoulos Christos
- Polymeropoulos Mihael H.
- Polymeropoulos Vasilios
- Pongpanich Monnat
- Porteous David J.
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- Poscente Monica
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- Puusepp Mairo
- Quinodoz Mathieu
- Quinodoz Mathieu
- Quiros-Roldan Eugenia
- Rader Daniel
- Rafaels Nicholas
- Raggi Pamela
- Ragoussis Jiannis
- Rahmouni Souad
- Raimondi Francesco
- Rancan Ilaria
- Rand Kristin
- Ravaglia Sabrina
- Regina J.
- Reimann Ene
- Rendon Augusto
- Renieri Alessandra
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- Rhead Brooke
- Rhodes Daniel
- Richards J. Brent
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- Ringmets Inge
- Ripamonti Diego
- Ripatti Samuli
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- Riva Agostino
- Rivolta Carlo
- Rivolta Carlo
- Rizzi Marco
- Rizzo Caterina Lo
- Roberts Genevieve
- Robles Veronica
- Rochat-Stettler L.
- Rogne Tormod
- Rojo Silvia
- Romani Davide
- Rooyackers Olav
- Rossetti Barbara
- Rovere Maria Teresa La
- Rudkin Justine K.
- Ruiz Luong
- Ruiz-Jaén Francisca
- Ruotsalainen Sanni
- Rusconi Stefano
- Russo Roberta
- Sabrina Ravaglia
- Saeedi Morteza
- Safa Nishat
- Safieh Leen Abu
- Salerni Lorenzo
- Salib Irene
- Samir Amr
- Sanarico Maurizio
- Sanguinetti Maurizio
- Sankaran Vijay G.
- Sarma Gopal
- Sarno Laura Di
- Sarzi-Braga Simona
- Satterstrom F. Kyle
- Sauvage Anne-Sophie
- Sawaji Mona
- Scaggiante Renzo
- Scala Raffaele
- Schadt Eric E.
- Schiaroli Elisabetta
- Schurr Erwin
- Scolletta Sabino
- Scott Richard H.
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- Segala Francesco Vladimiro
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- Shortt Jonathan
- Shotelersuk Vorasuk
- Shrine Nick
- Siano Matteo
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- Smieszek Sandra P.
- Smith Albert V.
- Smoller Jordan W.
- Sobh Ali
- Sodsai Pimpayao
- Soler Pere
- Solligard Erik
- Solomonson Matthew
- Solomonson Matthew
- Soranzo Nicole
- Soriano Alex
- Spargi Genni
- Spector Tim D.
- Spencer Chris C. A.
- Spertilli Chiara
- Squeo Gabriella Maria
- Starkopf Joel
- Stella Alessandra
- Stevens Christine
- Stuckey Alex
- Suardi Claudia
- Suchartlikitwong Pintip
- Suh N.
- Suh Noémie
- Suliman Bandar A.
- Sumoy Lauro
- Sun Yan V.
- Suttels V.
- Suttichet Thitima B.
- Tabri Jekaterina
- Tacconi Danilo
- Tadi Hengameh Ansari
- Tadini E.
- Tahmasebi Farah
- Tamm Anu
- Tanfoni Marco
- Tang Lara
- Tardif Nicolas
- Tavecchia Luisa
- Tenesa Albert
- Thompson Ryan C.
- THYS Marie
- Timmers Paul R. H. J.
- Tiseo Giusy
- Tita Rossella
- Tobin Martin D.
- Tommasi Andrea
- Torky Mohamed S.
- Torrents David
- Torvorapanit Pattama
- Trankiem Amy
- Trembath Richard C.
- Trembath Richard C.
- Trivedi Bhavi
- Trivedi Bhavi
- Trogstad Lill-Iren S.
- Trotta Tullio
- Tsao Phil
- Tschopp J.
- Tselios Chris
- Tsuo Kristin
- Tumbarello Mario
- Turley Patrick
- Uitterlinden Andre G.
- Underwood Slayton J.
- Vaghi Massimo
- Valente Serafina
- Valentino Floriana
- van Blokland Irene
- van Heel David
- van Heel David A.
- van Heel David A.
- Van Singer M.
- Vecchia Marco
- Veerapen Kumar
- Venn Laura D.
- Venturelli Sophie
- Vergori Alessandra
- Verma Anurag
- Verma Shefali S.
- Verzuri Agnese
- Viala B.
- Villalonga Joan Montaner
- Vincenti Antonella
- Viollet R. Merlet
- Vivo Oreste De
- Voide Cathy
- Voide Cathy
- Vollenweider P.
- Vollenweider P.
- von Hohenstaufen Kathrin Aprile
- von Mering C.
- Vonk Judith. M.
- Vulesevic Branka
- Wain Louise V.
- Walker Susan
- Walters Raymond K.
- Wang Jiongming
- Wang Xueyang
- Wanying Zhu
- Warmerdam Robert
- Weiss Scott T.
- Wicks Stephen J.
- Willer Cristen
- Williams Alexander T.
- Wilson Daniel J.
- Wilson James F.
- Wolford Brooke
- Wolford Brooke
- Wolford Brooke
- Woolley Ann E.
- Wozniak H.
- Wright John
- Wright John
- Wyllie David H.
- Xue Xiaoqing
- Yadav Ashish
- Yassen Amr M.
- Zanella Isabella
- Zeberg Hugo
- Zguro Kristina
- Zhang Miao
- Zhao Jing Hua
- Zhou Wei
- Zhou Wei
- Zlatopolsky Menachem
- zu Bentrup F. Meyer
- Zucchi Patrizia
- Zyndorf Marissa
- Zöllner Sebastian
- Åsvold Bjørn Olav
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
peer reviewe
- …