150 research outputs found
Pinned modes in lossy lattices with local gain and nonlinearity
We introduce a discrete linear lossy system with an embedded "hot spot" (HS),
i.e., a site carrying linear gain and complex cubic nonlinearity. The system
can be used to model an array of optical or plasmonic waveguides, where
selective excitation of particular cores is possible. Localized modes pinned to
the HS are constructed in an implicit analytical form, and their stability is
investigated numerically. Stability regions for the modes are obtained in the
parameter space of the linear gain and cubic gain/loss. An essential result is
that the interaction of the unsaturated cubic gain and self-defocusing
nonlinearity can produce stable modes, although they may be destabilized by
finite amplitude perturbations. On the other hand, the interplay of the cubic
loss and self-defocusing gives rise to a bistability.Comment: Phys. Rev. E (in press
Hydrogen Phases on the Surface of a Strongly Magnetized Neutron Star
The outermost layers of some neutron stars are likely to be dominated by
hydrogen, as a result of fast gravitational settling of heavier elements. These
layers directly mediate thermal radiation from the stars, and determine the
characteristics of X-ray/EUV spectra. For a neutron star with surface
temperature T\lo 10^6 K and magnetic field B\go 10^{12} G, various forms of
hydrogen can be present in the envelope, including atom, poly-molecules, and
condensed metal. We study the physical properties of different hydrogen phases
on the surface of a strongly magnetized neutron star for a wide range of field
strength and surface temperature . Depending on the values of and
, the outer envelope can be either in a nondegenerate gaseous phase or in a
degenerate metallic phase. For T\go 10^5 K and moderately strong magnetic
field, B\lo 10^{13} G, the envelope is nondegenerate and the surface material
gradually transforms into a degenerate Coulomb plasma as density increases. For
higher field strength, G, there exists a first-order phase
transition from the nondegenerate gaseous phase to the condensed metallic
phase. The column density of saturated vapor above the metallic hydrogen
decreases rapidly as the magnetic field increases or/and temperature decreases.
Thus the thermal radiation can directly emerge from the degenerate metallic
hydrogen surface. The characteristics of surface X-ray/EUV emission for
different phases are discussed. A separate study concerning the possibility of
magnetic field induced nuclear fusion of hydrogen on the neutron star surface
is also presented.Comment: TeX, 35 pages including 6 postscript figures. To be published in Ap
Hydrogen Molecules In Superstrong Magnetic Field: II. Excitation Levels
We study the energy levels of H molecules in a superstrong magnetic field
(B\go 10^{12} G), typically found on the surfaces of neutron stars. The
interatomic interaction potentials are calculated by a Hartree-Fock method with
multi-configurations assuming electrons are in the ground Landau state. Both
the aligned configurations and arbitrary orientations of the molecular axis
with respect to the magnetic field axis are considered. Different types of
molecular excitations are then studied: electronic excitations, aligned (along
the magnetic axis) vibrational excitations, transverse vibrational excitations
(a constrained rotation of the molecular axis around the magnetic field line).
Similar results for the molecular ion H are also obtained and compared
with previous variational calculations. Both numerical results and analytical
fitting formulae are given for a wide range of field strengths. In contrast to
the zero-field case, it is found that the transverse vibrational excitation
energies can be larger than the aligned vibration excitation, and they both can
be comparable or larger than the electronic excitations. For B\go
B_{crit}=4.23\times 10^{13} G, the Landau energy of proton is appreciable and
there is some controversy regarding the dissociation energy of H. We show
that H is bound even for and that neither proton has a Landau
excitation in the ground molecular state.Comment: Revtex (45 pages), 3 postscript figures; Phys. Rev. A in pres
Role of P-Glycoprotein and the Intestine in the Excretion of DPC 333 [(2R)-2-{(3R)-3-Amino-3-[4-(2-methylquinolin- 4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy- 4-methylpentanamide] in Rodents
ABSTRACT: The role of the intestine in the elimination of (2R)-2-{(3R)-3-amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}
Prognostic values of EORTC QLQ-C30 and QLQ-HCC18 index-scores in patients with hepatocellular carcinoma – clinical application of health-related quality-of-life data
Defining Global Benchmarks for Laparoscopic Liver Resections: An International Multicenter Study
PDRs4All IV. An embarrassment of riches: Aromatic infrared bands in the Orion Bar
(Abridged) Mid-infrared observations of photodissociation regions (PDRs) are
dominated by strong emission features called aromatic infrared bands (AIBs).
The most prominent AIBs are found at 3.3, 6.2, 7.7, 8.6, and 11.2 m. The
most sensitive, highest-resolution infrared spectral imaging data ever taken of
the prototypical PDR, the Orion Bar, have been captured by JWST. We provide an
inventory of the AIBs found in the Orion Bar, along with mid-IR template
spectra from five distinct regions in the Bar: the molecular PDR, the atomic
PDR, and the HII region. We use JWST NIRSpec IFU and MIRI MRS observations of
the Orion Bar from the JWST Early Release Science Program, PDRs4All (ID: 1288).
We extract five template spectra to represent the morphology and environment of
the Orion Bar PDR. The superb sensitivity and the spectral and spatial
resolution of these JWST observations reveal many details of the AIB emission
and enable an improved characterization of their detailed profile shapes and
sub-components. While the spectra are dominated by the well-known AIBs at 3.3,
6.2, 7.7, 8.6, 11.2, and 12.7 m, a wealth of weaker features and
sub-components are present. We report trends in the widths and relative
strengths of AIBs across the five template spectra. These trends yield valuable
insight into the photochemical evolution of PAHs, such as the evolution
responsible for the shift of 11.2 m AIB emission from class B in
the molecular PDR to class A in the PDR surface layers. This
photochemical evolution is driven by the increased importance of FUV processing
in the PDR surface layers, resulting in a "weeding out" of the weakest links of
the PAH family in these layers. For now, these JWST observations are consistent
with a model in which the underlying PAH family is composed of a few species:
the so-called 'grandPAHs'.Comment: 25 pages, 10 figures, to appear in A&
PDRs4All II: JWST's NIR and MIR imaging view of the Orion Nebula
The JWST has captured the most detailed and sharpest infrared images ever
taken of the inner region of the Orion Nebula, the nearest massive star
formation region, and a prototypical highly irradiated dense photo-dissociation
region (PDR). We investigate the fundamental interaction of far-ultraviolet
photons with molecular clouds. The transitions across the ionization front
(IF), dissociation front (DF), and the molecular cloud are studied at
high-angular resolution. These transitions are relevant to understanding the
effects of radiative feedback from massive stars and the dominant physical and
chemical processes that lead to the IR emission that JWST will detect in many
Galactic and extragalactic environments. Due to the proximity of the Orion
Nebula and the unprecedented angular resolution of JWST, these data reveal that
the molecular cloud borders are hyper structured at small angular scales of
0.1-1" (0.0002-0.002 pc or 40-400 au at 414 pc). A diverse set of features are
observed such as ridges, waves, globules and photoevaporated protoplanetary
disks. At the PDR atomic to molecular transition, several bright features are
detected that are associated with the highly irradiated surroundings of the
dense molecular condensations and embedded young star. Toward the Orion Bar
PDR, a highly sculpted interface is detected with sharp edges and density
increases near the IF and DF. This was predicted by previous modeling studies,
but the fronts were unresolved in most tracers. A complex, structured, and
folded DF surface was traced by the H2 lines. This dataset was used to revisit
the commonly adopted 2D PDR structure of the Orion Bar. JWST provides us with a
complete view of the PDR, all the way from the PDR edge to the substructured
dense region, and this allowed us to determine, in detail, where the emission
of the atomic and molecular lines, aromatic bands, and dust originate
PDRs4All III: JWST's NIR spectroscopic view of the Orion Bar
(Abridged) We investigate the impact of radiative feedback from massive stars
on their natal cloud and focus on the transition from the HII region to the
atomic PDR (crossing the ionisation front (IF)), and the subsequent transition
to the molecular PDR (crossing the dissociation front (DF)). We use
high-resolution near-IR integral field spectroscopic data from NIRSpec on JWST
to observe the Orion Bar PDR as part of the PDRs4All JWST Early Release Science
Program. The NIRSpec data reveal a forest of lines including, but not limited
to, HeI, HI, and CI recombination lines, ionic lines, OI and NI fluorescence
lines, Aromatic Infrared Bands (AIBs including aromatic CH, aliphatic CH, and
their CD counterparts), CO2 ice, pure rotational and ro-vibrational lines from
H2, and ro-vibrational lines HD, CO, and CH+, most of them detected for the
first time towards a PDR. Their spatial distribution resolves the H and He
ionisation structure in the Huygens region, gives insight into the geometry of
the Bar, and confirms the large-scale stratification of PDRs. We observe
numerous smaller scale structures whose typical size decreases with distance
from Ori C and IR lines from CI, if solely arising from radiative recombination
and cascade, reveal very high gas temperatures consistent with the hot
irradiated surface of small-scale dense clumps deep inside the PDR. The H2
lines reveal multiple, prominent filaments which exhibit different
characteristics. This leaves the impression of a "terraced" transition from the
predominantly atomic surface region to the CO-rich molecular zone deeper in.
This study showcases the discovery space created by JWST to further our
understanding of the impact radiation from young stars has on their natal
molecular cloud and proto-planetary disk, which touches on star- and planet
formation as well as galaxy evolution.Comment: 52 pages, 30 figures, submitted to A&
Large expert-curated database for benchmarking document similarity detection in biomedical literature search
Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe
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