557 research outputs found
Usefulness of serotoninergic challenge with oral citalopram
- Author
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Anti-Stress Effects of Carnosine on Restraint-Evoked Immunocompromise in Mice through Spleen Lymphocyte Number Maintenance
- Author
- A Gross
- A Hipkiss
- AJ Arif
- AJ Silverman
- B Janssen
- Bun Tsoi
- C Corona
- C Ito
- CJH Woodward
- CM Pariante
- D Hockenbery
- D Miller
- DM Silberman
- EP Zorrilla
- EV Yang
- F Berthiaume
- F Boldizsar
- G McFarland
- G McFarland
- H Kurihara
- H Kurihara
- H Otani
- Hiroshi Kurihara
- I Mazurkiewicz-Kwilecki
- J Zapp
- J Zhang
- JD Amaral
- JI Webster Marketon
- K Hatanaka
- K Soliman
- Keiichi Abe
- KG Wolter
- KML Tan
- L Piriou
- LD Van de Kar
- M Vizuete
- Martin Gerbert Frasch
- N Hanna
- N Sakai
- N Zamzami
- P Hyland
- R Holliday
- R Kozan
- RH Bonneau
- Rong-Rong He
- RR He
- RR He
- S Cuzzocrea
- S Fleisher-Berkovich
- SL Planey
- SL Planey
- TR Jan
- Wei-Xi Li
- WJ Reddy
- Xiao-Di Li
- YF Shi
- Yi-Fang Li
- YQ Lu
- YT Lee
- YY Zhu
- Publication venue
- Public Library of Science
- Publication date
- 12/04/2012
- Field of study
Carnosine (β-alanyl-L-histidine), a naturally occurring dipeptide, has been characterized as a putative neurotransmitter and serves as a reservoir for brain histamine, which could act on histaminergic neurons system to relieve stress-induced damages. However, understanding of the role of carnosine in stress-evoked immunocompromise is limited. In this study, results showed that when mice were subjected to restraint stress, spleen index and the number of spleen lymphocytes including Natural Killer (NK) cells were obviously decreased. Results also demonstrated that restraint stress decreased the cytotoxic activity of NK cells per spleen (LU10/spleen) while the activity of a single NK cell (LU10/106 cells) was not changed. However, oral administration of carnosine (150 and 300 mg/kg) increased spleen index and number of spleen lymphocytes (including NK cells), and elevated the cytotoxic activity of NK cells per spleen in restraint-stressed mice. These results indicated that carnosine ameliorated stress-evoked immunocompromise through spleen lymphocyte number maintenance. Carnosine was further found to reduce stress-induced elevation of plasma corticosterone level. On the other hand, results showed that carnosine and RU486 (a glucocorticoids receptor antagonist) treatment prevented the reduction in mitochondrion membrane potential and the release of mitochondrial cytochrome c into cytoplasm, increased Bcl-2/Bax mRNA ratio, as well as decreased terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL)-positive cells in spleen lymphocytes of stressed mice. The results above suggested that the maintenance of spleen lymphocyte number by carnosine was related with the inhibition of lymphocytes apoptosis caused by glucocorticoids overflow. The stimulation of lymphocyte proliferation by carnosine also contributed to the maintenance of spleen lymphocyte number in stressed mice. In view of the elevated histamine level, the anti-stress effects of carnosine on restraint-evoked immunocompromise might be via carnosine-histamine metabolic pathway. Taken together, carnosine maintained spleen lymphocyte number by inhibiting lymphocyte apoptosis and stimulating lymphocyte proliferation, thus prevented immunocompromise in restraint-stressed mice
Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at √ s = 8 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abbott DC
- Abeling K
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abud AA
- Abulaiti Y
- Acharya BS
- Achkar B
- Adachi S
- Adam L
- Adamczyk L
- Adamek L
- Adelman J
- Adersberger M
- Adiguzel A
- Adorni S
- Adye T
- Affolder AA
- Afik Y
- Agapopoulou C
- Agaras MN
- Aggarwal A
- Agheorghiesei C
- Aguilar-Saavedra JA
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- Ahmed WS
- Ai X
- Aielli G
- Akatsuka S
- Akesson TPA
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- Al Khoury K
- Alberghi GL
- Albert J
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- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexopoulos T
- Alfonsi A
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- Alviggi MG
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- Troncon C
- Trovato F
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- Tseng JC-L
- Tsiareshka P
- Tsirigotis A
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- Tskhadadze EG
- Tsopoulou M
- Tsukerman II
- Tsulaia V
- Tsuno S
- Tsybychev D
- Tu Y
- Tudorache A
- Tudorache V
- Tulbure TT
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- Turchikhin S
- Turgeman D
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- Tzamarias S
- Tzovara E
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- Unno Y
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- Urquijo P
- Usai G
- Uysal Z
- Vacek V
- Vachon B
- Vadla KOH
- Vaidya A
- Valderanis C
- Vale MAB
- Valente M
- Valentinetti S
- Valero A
- Valery L
- Vallance RA
- Vallier A
- Van Daalen TR
- Van Gemmeren P
- Van Vulpen I
- Vanadia M
- Vandelli W
- Vandenbroucke M
- Vandewall ER
- Vaniachine A
- Vannicola D
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- Varnes EW
- Varni C
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- Varouchas D
- Varvell KE
- Vasile ME
- Vasquez GA
- Vazeille F
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- Vazquez CJB
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- Vecchio V
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- Veloce LM
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- Vercesi V
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- von Buddenbrock SE
- Von Toerne E
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- Vos M
- Vossebeld JH
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- Vranjes N
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- Vreeswijk M
- Vuillermet R
- Vukotic I
- Wagner P
- Wagner W
- Wagner-Kuhr J
- Wahdan S
- Wahlberg H
- Walbrecht VM
- Walder J
- Walker R
- Walker SD
- Walkowiak W
- Wallangen V
- Wang AM
- Wang AZ
- Wang C
- Wang F
- Wang H
- Wang J
- Wang P
- Wang Q
- Wang R
- Wang R-J
- Wang SM
- Wang W
- Wang WT
- Wang WX
- Wang Y
- Wang Z
- Wanotayaroj C
- Warburton A
- Ward CP
- Wardrope DR
- Warrack N
- Washbrook A
- Watson AT
- Watson MF
- Watts G
- Waugh BM
- Webb AF
- Webb S
- Weber C
- Weber MS
- Weber SA
- Weber SM
- Weidberg AR
- Weingarten J
- Weirich M
- Weiser C
- Wells PS
- Wenaus T
- Wengler T
- Wenig S
- Wermes N
- Werner MD
- Wessels M
- Weston TD
- Whalen K
- Whallon NL
- Wharton AM
- White A
- White AS
- White MJ
- Whiteson D
- Whitmore BW
- Wiedenmann W
- Wiel C
- Wielers M
- Wieseotte N
- Wiglesworth C
- Wiik-Fuchs LAM
- Wilkens HG
- Wilkins LJ
- Williams HH
- Williams S
- Willis C
- Willocq S
- Wingerter-Seez I
- Winkels E
- Winklmeier F
- Winston OJ
- Winter BT
- Wittgen M
- Wobisch M
- Wolf A
- Wolf TMH
- Wolff R
- Wolker R
- Wollrath J
- Wolter MW
- Wolters H
- Wong VWS
- Woods NL
- Worm SD
- Wosiek BK
- Wozniak KW
- Wraight K
- Wu SL
- Wu X
- Wu Y
- Wyatt TR
- Wynne BM
- Xella S
- Xi Z
- Xia L
- Xiao X
- Xiotidis I
- Xu D
- Xu H
- Xu L
- Xu T
- Xu W
- Xu Z
- Yabsley B
- Yacoob S
- Yajima K
- Yallup DP
- Yamaguchi N
- Yamaguchi Y
- Yamamoto A
- Yamatani M
- Yamazaki T
- Yamazaki Y
- Yan Z
- Yang HJ
- Yang HT
- Yang S
- Yang T
- Yang X
- Yang Y
- Yao W-M
- Yap YC
- Yasu Y
- Yatsenko E
- Ye H
- Ye J
- Ye S
- Yeletskikh I
- Yexley MR
- Yigitbasi E
- Yildiz HD
- Yorita K
- Yoshihara K
- Young C
- Young CJS
- Yu J
- Yuan R
- Yue X
- Zaazoua M
- Zabinski B
- Zacharis G
- Zaffaroni E
- Zahreddine J
- Zaitsev AM
- Zakareishvili T
- Zakharchuk N
- Zambito S
- Zanzi D
- Zaripovas DR
- Zeissner S
- Zeitnitz C
- Zemaityte G
- Zeng JC
- Zenin O
- Zenis T
- Zerwas D
- Zgubic M
- Zhang B
- Zhang DF
- Zhang G
- Zhang H
- Zhang J
- Zhang L
- Zhang M
- Zhang R
- Zhang S
- Zhang X
- Zhang Y
- Zhang Z
- Zhao P
- Zhao Z
- Zhemchugov A
- Zheng Z
- Zhong D
- Zhou B
- Zhou C
- Zhou M
- Zhou MS
- Zhou N
- Zhou Y
- Zhu C
- Zhu CG
- Zhu H
- Zhu HL
- Zhu J
- Zhu Y
- Zhuang X
- Zhukov K
- Zhulanov V
- Zieminska D
- Zimine N
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zivkovic L
- Zobernig G
- Zoccoli A
- Zoch K
- Zorbas TG
- Zou R
- Zu Theenhausen HM
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses 20.3 fb−1 of √ s = 8 TeV data collected in 2012 with the ATLAS detector at the LHC. Events are required to have at least one jet with pT > 120 GeV and no leptons. Nine signal regions are considered with increasing missing transverse momentum requirements between Emiss T > 150 GeV and Emiss T > 700 GeV. Good agreement is observed between the number of events in data and Standard Model expectations. The results are translated into exclusion limits on models with either large extra spatial dimensions, pair production of weakly interacting dark matter candidates, or production of very light gravitinos in a gauge-mediated supersymmetric model. In addition, limits on the production of an invisibly decaying Higgs-like boson leading to similar topologies in the final state are presente
Clinical aspects of a phase I trial of 5,6-dimethylxanthenone-4-acetic acid (DMXAA), a novel antivascular agent
- Author
- A Dowlati
- AM Eggermont
- B C Baguley
- B D Evans
- BC Baguley
- BG Siim
- C Ruegg
- CJ Lash
- D J Porter
- DJ Chaplin
- DJ Kerr
- DJ Kerr
- DR Spriggs
- EA Carswell
- F Otto
- FB Pruijn
- FJ Lejeune
- G W Halbert
- GH Algire
- GJ Finlay
- GJ Rustin
- GJS Rustin
- GP Smith
- GW Rewcastle
- GW Rewcastle
- H Anderson
- H Coley-Nauts
- HP Davis
- IN Olver
- J Griggs
- J Rubin
- JR Kanwar
- K Aytemir
- K Bellenger
- KA Havlin
- KA Sporer
- L Gumbrell
- LD Van de Kar
- LJ Old
- LJ Zwi
- LJ Zwi
- LJ Zwi
- LM Ching
- LM Ching
- LM Ching
- M B Jameson
- M Philpott
- M Philpott
- M R McCrystal
- M Small
- MC Bibby
- MF Marmor
- MR Horsman
- O Stücker
- P I Thompson
- P Kestell
- P Kestell
- P Kligfield
- PJ O'Dwyer
- R Murata
- RB Pedley
- RB Pedley
- RB Weiss
- RF DeVore
- RM Wallis
- S Cliffe
- SB Kaye
- SM Galbraith
- SM Galbraith
- TM Brown
- V J Harvey
- WR Wilson
- WR Wilson
- YS Lew
- Z Cao
- Publication venue
- Nature Publishing Group
- Publication date
- Field of study
3,4-Methylenedioxymethamphetamine (MDMA) neurotoxicity in rats: a reappraisal of past and present findings
- Author
- A Carlsson
- A Frazer
- A Kankaanpaa
- A Lavelle
- A Malpass
- AC Parrott
- AC Parrott
- AD Levy
- AO Mechan
- AR Green
- AR Green
- BK Yamamoto
- C Charlier
- CE Johanson
- CG Gurtman
- CJ Schmidt
- CJ Schmidt
- CR Scanzello
- CR White
- D Crespi
- D Pubill
- D Wu
- DB Campbell
- DB Campbell
- DE Nichols
- DL Commins
- DM Stone
- DS Harris
- E Gouzoulis-Mayfrank
- E O’Hearn
- E O’Shea
- E Ratzenboeck
- EJ Bull
- EJ Bull
- F Bai
- F Schifano
- FS Hall
- FX Vollenweider
- G Battaglia
- G Battaglia
- G Battaglia
- G Gerra
- G Gerra
- G Rudnick
- G Wakonigg
- G Winneke
- GA Gudelsky
- GA Ricaurte
- GA Ricaurte
- GB West
- GK Aghajanian
- GS Yacoubian Jr.
- HG Baumgarten
- HG Series
- HG Series
- HH Maurer
- HM Marston
- HW Steinbusch
- I Escobedo
- I Mahmood
- IS McGregor
- J Lyles
- JA Banken
- JC Cole
- JE Malberg
- JE Sprague
- JF Nash Jr
- JH Lin
- JH Lin
- JL Fitzgerald
- JL Fitzgerald
- JP O’Callaghan
- JP O’Callaghan
- JP O’Callaghan
- JS Partilla
- JS Sprouse
- KC Fone
- KC Morley
- KF Jensen
- KT Finnegan
- L Matuszewich
- L Reneman
- L Romero
- LC Schmued
- LC Schmued
- LD Kar Van de
- LG Kirby
- LH Gold
- LJ Spanos
- LS Seiden
- M Hajos
- M Kalia
- M Kleiber
- M Mas
- M Shankaran
- M Tancer
- MA Geyer
- MD Schechter
- ME Liechti
- ME Liechti
- ME Molliver
- MG Bankson
- MG McNamara
- MH Baumann
- MH Baumann
- MH Baumann
- MH Baumann
- MI Colado
- Michael H. Baumann
- MJ Landry
- MJ Morgan
- MJ Zigmond
- ML Forsling
- MP Johnson
- N Aguirre
- PA O’Cain
- R Doblin
- R Oberlender
- R Torre de la
- R Torre de la
- R Torre de la
- RA Glennon
- RA Lyon
- RB Rothman
- RB Rothman
- RB Rothman
- RC Switzer 3rd
- RE Poland
- RE Poland
- RI Dafters
- RI Dafters
- Richard B. Rothman
- S Benmansour
- S Schenk
- SE Gartside
- SE Gartside
- SF Noujaim
- SJ Kish
- T Byrne
- T Chu
- TE Robinson
- TJ Monks
- UV Berger
- V Setola
- VC Moser
- W Slikker Jr.
- X Wang
- X Wang
- Xiaoying Wang
- Publication venue
- Springer-Verlag
- Publication date
- 01/01/2006
- Field of study
RATIONALE: 3,4-Methylenedioxymethamphetamine (MDMA) is a widely abused illicit drug. In animals, high-dose administration of MDMA produces deficits in serotonin (5-HT) neurons (e.g., depletion of forebrain 5-HT) that have been interpreted as neurotoxicity. Whether such 5-HT deficits reflect neuronal damage is a matter of ongoing debate. OBJECTIVE: The present paper reviews four specific issues related to the hypothesis of MDMA neurotoxicity in rats: (1) the effects of MDMA on monoamine neurons, (2) the use of “interspecies scaling” to adjust MDMA doses across species, (3) the effects of MDMA on established markers of neuronal damage, and (4) functional impairments associated with MDMA-induced 5-HT depletions. RESULTS: MDMA is a substrate for monoamine transporters, and stimulated release of 5-HT, NE, and DA mediates effects of the drug. MDMA produces neurochemical, endocrine, and behavioral actions in rats and humans at equivalent doses (e.g., 1–2 mg/kg), suggesting that there is no reason to adjust doses between these species. Typical doses of MDMA causing long-term 5-HT depletions in rats (e.g., 10–20 mg/kg) do not reliably increase markers of neurotoxic damage such as cell death, silver staining, or reactive gliosis. MDMA-induced 5-HT depletions are accompanied by a number of functional consequences including reductions in evoked 5-HT release and changes in hormone secretion. Perhaps more importantly, administration of MDMA to rats induces persistent anxiety-like behaviors in the absence of measurable 5-HT deficits. CONCLUSIONS: MDMA-induced 5-HT depletions are not necessarily synonymous with neurotoxic damage. However, doses of MDMA which do not cause long-term 5-HT depletions can have protracted effects on behavior, suggesting even moderate doses of the drug may pose risks
Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170.
- Author
- A Janer
- AC Antoniou
- AC Antoniou
- AC Antoniou
- AK Dunbier
- Ake Borg
- Alfons Meindl
- Alison M Dunning
- AM Dunning
- Amanda E Toland
- Ana Osorio
- Anders Bojesen
- Andrew K Godwin
- Andrew Lee
- Angela Cox
- Anja Rudolph
- Anna González-Neira
- Anna H Wu
- Anna Jakubowska
- Anna Marie Mulligan
- Anna von Wachenfeldt
- Anne-Lise Borresen-Dale
- Annegien Broeks
- Annika Lindblom
- Ans M W van den Ouweland
- Anthony Swerdlow
- Antoinette Hollestelle
- Antonis C Antoniou
- Arjen R Mensenkamp
- Artitaya Lophatananon
- Arto Mannermaa
- AV Spencer
- Ava Kwong
- Banu K Arun
- Barbara Burwinkel
- Barbara J Perkins
- Bent Ejlertsen
- Bernard Peissel
- Bernardo Bonanni
- Beth Y Karlan
- Brian E Henderson
- C Curtis
- C Turnbull
- CA Haiman
- Carl Blomqvist
- Carmel Apicella
- Caroline Seynaeve
- Catherine M Phelan
- Catherine S Healey
- Cecilia M Dorfling
- Celine Vachon
- Charlotte Sagne
- Chen-Yang Shen
- Cheng Har Yip
- Chiu-chen Tseng
- Christian F Singer
- Christine B Ambrosone
- Christine Rappaport
- Christopher A Haiman
- Christopher Scott
- Christy Woolcott
- CJ Crandall
- Claudine Isaacs
- D Hnisz
- Daehee Kang
- Daniel Barrowdale
- David E Goldgar
- Deborah Thompson
- Debra Frost
- Diana Torres
- Dieter Niederacher
- Diether Lambrechts
- DL Koller
- DM Glubb
- Dominique Stoppa-Lyonnet
- Douglas F Easton
- DR Barnes
- E Lim
- Ed Dicks
- Edith Olah
- Eitan Friedman
- Elena Lopez-Knowles
- Elinor J Sawyer
- Elizabeth J van Rensburg
- Esther M John
- Evgeny N Imyanitov
- Fergus J Couch
- FJ Couch
- Francesca Damiola
- Frederik Marme
- G Chenevix-Trench
- G Molyneux
- Gad Rennert
- Georgia Chenevix-Trench
- Gertraud Maskarinec
- Gillian Mitchell
- Gord Glendon
- Graham G Giles
- Hans Ehrencrona
- Hans Wildiers
- Haran Sivakumaran
- Hatef Darabi
- Heli Nevanlinna
- Henrik Flyger
- Hermann Brenner
- Hidemi Ito
- Hiltrud Brauch
- Hoda Anton-Culver
- Ian Tomlinson
- Irene Konstantopoulou
- Irene L Andrulis
- Isabel dos-Santos-Silva
- J Stone
- J Veeraraghavan
- Jacek Gronwald
- Jacques Simard
- Jan Lubinski
- Janet E Olson
- Jason S Lee
- Javier Benitez
- JD French
- Jeffrey N Weitzel
- Jennifer Stone
- Jenny Chang-Claude
- Jenny Lester
- Ji-Yeob Choi
- Jirong Long
- JJ Perry
- Joan Brunet
- Joe Dennis
- Johanna Rantala
- John L Hopper
- Jonathan Beesley
- Jonine Figueroa
- Jose I A Perez
- Joseph Vijai
- JR Perry
- JS Varghese
- Judy Garber
- Julia A Knight
- Julian Peto
- Juliet D French
- K Estrada
- Kamila Czene
- Karen A Pooley
- Karoline B Kuchenbaecker
- Katherine L Nathanson
- Kathleen B M Claes
- Katri Pylkäs
- Kay-Tee Khaw
- Keitaro Matsuo
- Keith Humphreys
- Kelly-Anne Phillips
- Kenneth Muir
- Kenneth Offit
- Kerstin Rhiem
- Kim De Leeneer
- Kristiina Aittomäki
- Kristine M Hillman
- Kyriaki Michailidou
- Laima Tihomirova
- Laura Ottini
- Laura Papi
- LD Ward
- Lee Eunjung
- Lenka Foretova
- Lesley McGuffog
- Louise Izatt
- M Ghoussaini
- M Yamamoto-Ibusuki
- Maartje J Hooning
- Mads Thomassen
- Mahdi Moradi Marjaneh
- Manjeet K Bolla
- Manuel R Teixeira
- Marc Tischkowitz
- Marco Montagna
- Margaret Hills
- Maria A Caligo
- Maria Kabisch
- Marion Piedmonte
- Marjanka K Schmidt
- Mark E Sherman
- Mark H Greene
- Mark S Goldberg
- Mary B Daly
- Mary Beth Terry
- Matthias W Beckmann
- Matti A Rookus
- Maya Ghoussaini
- ME Sherman
- Melissa C Southey
- Miguel de la Hoya
- Mikael Hartman
- Miquel Angel Pujana
- Miroslav Kapuscinski
- Mitch Dowsett
- Mitul Shah
- Monika Jarosz
- Montserrat García-Closas
- Muhammad Usman Rashid
- N Grabe
- N Mavaddat
- Nadine Tung
- Nadja Bogdanova-Markov
- Natasha Bogdanova
- NF Boyd
- Nicholas A Sinnott-Armstrong
- Nick Orr
- Noralane Lindor
- Norbert Arnold
- O Corradin
- Olga M Sinilnikova
- Olufunmilayo I Olopade
- Orland Diez
- Paolo Peterlongo
- Paolo Radice
- Paraskevi Apostolou
- Pascal Guénel
- Patricia A Ganz
- Paul Brennan
- Paul D P Pharoah
- Pei-Ei Wu
- Penny Soucy
- Per Hall
- Peter A Fasching
- Peter Devilee
- Peter J Hulick
- Phuong L Mai
- Q Cai
- Q Li
- Qin Wang
- Qiuyin Cai
- R Cowper-Sal·lari
- R Hein
- R Xiao
- Rachel Laframboise
- Rachel Rando
- Ramunas Janavicius
- Richard C Sallari
- Rita K Schmutzler
- Robert L Nussbaum
- Robert Luben
- Robert Winqvist
- Roger L Milne
- Rosa B Barkardottir
- Rulla Tamimi
- S Lindström
- S Lindström
- Sander Canisius
- Sara Margolin
- Saundra S Buys
- Siddhartha Kar
- Silje Nord
- Simon A Gayther
- Simon S Cross
- Simona Agata
- Siranoush Manoukian
- SL Edwards
- SN Stacey
- Sofia Khan
- Soo Chin Lee
- Soo H Teo
- Sook-Yee Yoon
- Stacey L Edwards
- Steve Ellis
- Stig E Bojesen
- Sue Healey
- Sue Kyung Park
- Suleeporn Sangrajrang
- Susan L Neuhausen
- Susan M Domchek
- Susanne Kaufmann
- Suzie Drury
- Sylvie Mazoyer
- Thilo Dörk
- Thomas V O Hansen
- Thérèse Truong
- Tomasz Huzarski
- Trinidad Caldes
- Ute Hamann
- VA McCormack
- Veli-Matti Kosma
- Vessela Kristensen
- Vilde Haakensen
- Volker Arndt
- W Zheng
- Wei Zheng
- William Blot
- Xiao-Ou Shu
- Yael Laitman
- Yu-Tang Gao
- Åslaug Helland
- Publication venue
- Nat Genet
- Publication date
- 01/01/2016
- Field of study
We analyzed 3,872 common genetic variants across the ESR1 locus (encoding estrogen receptor α) in 118,816 subjects from three international consortia. We found evidence for at least five independent causal variants, each associated with different phenotype sets, including estrogen receptor (ER(+) or ER(-)) and human ERBB2 (HER2(+) or HER2(-)) tumor subtypes, mammographic density and tumor grade. The best candidate causal variants for ER(-) tumors lie in four separate enhancer elements, and their risk alleles reduce expression of ESR1, RMND1 and CCDC170, whereas the risk alleles of the strongest candidates for the remaining independent causal variant disrupt a silencer element and putatively increase ESR1 and RMND1 expression.This is the author accepted manuscript. The final version is available from Nature Publishing Group via http://dx.doi.org/10.1038/ng.352
A short history of the 5-HT2C receptor: from the choroid plexus to depression, obesity and addiction treatment
- Author
- A Bilkei-Gorzo
- A Cathala
- A Closse
- A Enz
- A Fargin
- A Gobert
- A Husch
- A Milatovich
- A Pazos
- A Pazos
- A Pazos
- A Pazos
- A Pazos
- A Pazos
- AA Patkar
- AF Di Narzo
- AF Di Narzo
- AG Saltzman
- AH Rezvani
- AJ Grottick
- AJ Grottick
- AJ Grottick
- Angel Pazos
- B Rocha
- B Rocha
- B Wang
- BA Nic Dhonnchadha
- BA Rocha
- BJ Hoffman
- BL Roth
- BM Campbell
- C Becamel
- C Becamel
- C Becamel
- C Harvey-Lewis
- C Peyron
- C Waeber
- C Wang
- C Yan
- CA Winstanley
- CB Martin
- CB Martin
- CB Martin
- CM Burns
- CM Niswender
- CM Niswender
- D Abramowski
- D Benjamin
- D Hoyer
- D Hoyer
- D Hoyer
- D Hoyer
- D Hoyer
- D Hoyer
- D Hoyer
- D Hoyer
- D Hoyer
- D Hoyer
- D Hoyer
- D Hoyer
- D Hoyer
- D Hoyer
- D Julius
- D Julius
- D Ruedi-Bettschen
- D Wacker
- DA Wirshing
- Daniel Hoyer
- DB Pritchett
- DD Lam
- DE Nichols
- DF Manvich
- DF Manvich
- DM Tomkins
- DN Middlemiss
- DW Bonhaus
- E Steed
- EA Hackler
- EA Hackler
- EC Pooley
- ED Berglund
- ED Levin
- EM Somerville
- EZ Xie
- F Jenck
- G Bagdy
- G Di Giovanni
- G Di Giovanni
- G Di Giovanni
- G Di Giovanni
- G Engel
- G Engel
- G Engel
- G Kennett
- G Mengod
- G Zhang
- GA Higgins
- GA Kennett
- GA Kennett
- GA Kennett
- GA Kennett
- GA Kennett
- GE Bigford
- GL Dalton
- GM Leggio
- GP Reynolds
- GP Reynolds
- H Canton
- H Gozlan
- H Lubbert
- H Rippberger
- H Schellekens
- H Zhu
- HN Doods
- HO Kalkman
- HO Kalkman
- HY Meltzer
- I Gurevich
- I Lucki
- J Dunlop
- J Dunlop
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- JH Gaddum
- JH Shen
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- JM Kasper
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- Jose M. Palacios
- JP Christianson
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- JR Martin
- K Fouad
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- MJ Millan
- MJ Millan
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- MR Bennett
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- MT Lowy
- NC Anastasio
- NC Anastasio
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- NJ Stam
- NW Pedigo
- P Schoeffter
- P Schoeffter
- PB Bradley
- PG Clifton
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- Q Wang
- R Flomen
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- R Kleene
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- SM Southwick
- SP Ji
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- SR Howes
- SR Smith
- SR Smith
- SS Bergen Jr
- T Murotani
- TD Werry
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- Publication date
- 01/01/2017
- Field of study
This paper is a personal account on the discovery and characterization of the 5-HT2C receptor (first known as the 5- HT1C receptor) over 30 years ago and how it translated into a number of unsuspected features for a G protein-coupled receptor (GPCR) and a diversity of clinical applications. The 5-HT2C receptor is one of the most intriguing members of the GPCR superfamily. Initially referred to as 5-HT1CR, the 5-HT2CR was discovered while studying the pharmacological features and the distribution of [3H]mesulergine-labelled sites, primarily in the brain using radioligand binding and slice autoradiography. Mesulergine (SDZ CU-085), was, at the time, best defined as a ligand with serotonergic and dopaminergic properties. Autoradiographic studies showed remarkably strong [3H]mesulergine-labelling to the rat choroid plexus. [3H]mesulergine-labelled sites had pharmacological properties different from, at the time, known or purported 5-HT receptors. In spite of similarities with 5-HT2 binding, the new binding site was called 5-HT1C because of its very high affinity for 5-HT itself. Within the following 10 years, the 5-HT1CR (later named 5- HT2C) was extensively characterised pharmacologically, anatomically and functionally: it was one of the first 5-HT receptors to be sequenced and cloned. The 5-HT2CR is a GPCR, with a very complex gene structure. It constitutes a rarity in theGPCR family: many 5-HT2CR variants exist, especially in humans, due to RNA editing, in addition to a few 5-HT2CR splice variants. Intense research led to therapeutically active 5-HT2C receptor ligands, both antagonists (or inverse agonists) and agonists: keeping in mind that a number of antidepressants and antipsychotics are 5- HT2CR antagonists/inverse agonists. Agomelatine, a 5-HT2CR antagonist is registered for the treatment of major depression. The agonist Lorcaserin is registered for the treatment of aspects of obesity and has further potential in addiction, especially nicotine/ smoking. There is good evidence that the 5-HT2CR is involved in spinal cord injury-induced spasms of the lower limbs, which can be treated with 5-HT2CR antagonists/inverse agonists such as cyproheptadine or SB206553. The 5-HT2CR may play a role in schizophrenia and epilepsy. Vabicaserin, a 5-HT2CR agonist has been in development for the treatment of schizophrenia and obesity, but was stopped. As is common, there is potential for further indications for 5-HT2CR ligands, as suggested by a number of preclinical and/or genome-wide association studies (GWAS) on depression, suicide, sexual dysfunction, addictions and obesity. The 5-HT2CR is clearly affected by a number of established antidepressants/antipsychotics and may be one of the culprits in antipsychotic-induced weight gain
Study of the spin and parity of the Higgs boson in diboson decays with the ATLAS detector
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- V. A. Schegelsky
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- V. B. Vinogradov
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- V. Bortolotto
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- V. Castillo Gimenez
- V. Cavaliere
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- V. D. Peshekhonov
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- V. E. Ozcan
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- W. Davey
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- W. Wiedenmann
- X. Chen
- X. Hu
- X. Ju
- X. Lei
- X. Lou
- X. Ruan
- X. Sun
- X. Wang
- X. Wu
- X. Zhang
- X. Zhao
- X. Zhuang
- Y Gao
- Y. A. Kurochkin
- Y. Abulaiti
- Y. Amaral Coutinho
- Y. Arai
- Y. B. Pan
- Y. Bai
- Y. Benhammou
- Y. Chen
- Y. Cheng
- Y. Coadou
- Y. Davygora
- Y. Enari
- Y. F. Ryabov
- Y. Fang
- Y. Gao
- Y. Guo
- Y. Hasegawa
- Y. Heng
- Y. Hernández Jiménez
- Y. Horii
- Y. Huang
- Y. Ikegami
- Y. Ilchenko
- Y. J. Schnellbach
- Y. Jiang
- Y. Kataoka
- Y. Kim
- Y. Komori
- Y. Kulchitsky
- Y. Li
- Y. Liu
- Y. Makida
- Y. Minami
- Y. Ming
- Y. Nagai
- Y. Nagasaka
- Y. Nakahama
- Y. Ninomiya
- Y. Okumura
- Y. Oren
- Y. Qin
- Y. Rozen
- Y. S. Gao
- Y. Sakurai
- Y. Sasaki
- Y. Silver
- Y. Smirnov
- Y. Sugaya
- Y. Takubo
- Y. Tayalati
- Y. Unno
- Y. Wu
- Y. Yamaguchi
- Y. Yamazaki
- Y. Yang
- Y. Yasu
- Y. Zhao
- Y. Zhu
- Yu. A. Tikhonov
- Z. Barnovska
- Z. D. Greenwood
- Z. Dolezal
- Z. Gecse
- Z. H. Citron
- Z. Hajduk
- Z. Hubacek
- Z. Idrissi
- Z. J. Grout
- Z. Kohout
- Z. Liang
- Z. M. Karpova
- Z. Marshall
- Z. Rurikova
- Z. V. Krumshteyn
- Z. Vykydal
- Z. Yan
- Z. Zhang
- Z. Zhao
- Z. Zinonos
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Studies of the spin, parity and tensor couplings of the Higgs boson in the H→ZZ∗→4ℓ, H→WW∗→eνμν and H→γγ decay processes at the LHC are presented. The investigations are based on 25fb−1 of pp collision data collected by the ATLAS experiment at √s=7 TeV and √s=8 TeV. The Standard Model (SM) Higgs boson hypothesis, corresponding to the quantum numbers JP=0+, is tested against several alternative spin scenarios, including non-SM spin-0 and spin-2 models with universal and non-universal couplings to fermions and vector bosons. All tested alternative models are excluded in favour of the SM Higgs boson hypothesis at more than 99.9 % confidence level. Using the H → ZZ∗ → 4ℓ and H → WW∗ → eνμν decays, the tensor structure of the interaction between the spin-0 boson and the SM vector bosons is also investigated. The observed distributions of variables sensitive to the non-SM tensor couplings are compatible with the SM predictions and constraints on the non-SM couplings are derived
Measurement of the t¯tZ and t¯tW cross sections in proton-proton collisions at √s=13 TeV with the ATLAS detector
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- Aad G
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- Zhemchugov A
- Zheng Z
- Zhong D
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- Zhulanov V
- Zibell A
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- Zimine NI
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zobernig G
- Zoccoli A
- Zoch K
- Zorbas TG
- Zou R
- Zur Nedden M
- Zwalinski L
- Álvarez Piqueras D
- Åkesson TPA
- Šfiligoj T
- Ženiš T
- Živković L
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2019
- Field of study
A measurement of the associated production of a top-quark pair (t¯t) with a vector boson (W, Z) in proton-proton collisions at a center-of-mass energy of 13 TeV is presented, using 36.1 fb−1 of integrated luminosity collected by the ATLAS detector at the Large Hadron Collider. Events are selected in channels with two same- or opposite-sign leptons (electrons or muons), three leptons or four leptons, and each channel is further divided into multiple regions to maximize the sensitivity of the measurement. The t¯tZ and t¯tW production cross sections are simultaneously measured using a combined fit to all regions. The best-fit values of the production cross sections are σt¯tZ=0.95±0.08stat±0.10syst pb and σt¯tW=0.87±0.13stat±0.14syst pb in agreement with the Standard Model predictions. The measurement of the t¯tZ cross section is used to set constraints on effective field theory operators which modify the t¯tZ vertex
Measurement of VH, H → b b ¯ production as a function of the vector-boson transverse momentum in 13 TeV pp collisions with the ATLAS detector
- Author
- Aaboud M
- Aad G
- Abbott B
- Abbott DC
- Abdinov O
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abud AA
- Abulaiti Y
- Acharya BS
- Adachi S
- Adam L
- Adamczyk L
- Adamek L
- Adelman J
- Adersberger M
- Adiguzel A
- Adorni S
- Adye T
- Affolder AA
- Afik Y
- Agapopoulou C
- Agaras MN
- Aggarwal A
- Agheorghiesei C
- Aguilar-Saavedra JA
- Ahmadov F
- Aielli G
- Akatsuka S
- Akesson TPA
- Akilli E
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- Al Khoury K
- Alberghi GL
- Alberich LC
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- Alconada Verzini MJ
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
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- Anders CF
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- Angelozzi I
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- Black KM
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- Bussey PJ
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- Calafiura P
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- Callea G
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- Castillo FL
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- Cheu E
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- Chevalerias TJA
- Chevalier L
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- de Renstrom PAB
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- Klingl T
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- Klitzner FF
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- Knue A
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- Kobayashi T
- Kobel M
- Kocian M
- Kodys P
- Koehler NM
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- Konig AC
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- Kotwal A
- Koulouris A
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- Kourkoumelis C
- Kourlitis E
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- Kozanecki W
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- Vilucchi E
- Vincter MG
- Vinogradov VB
- Vishwakarma A
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- Vivarelli I
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- von Buddenbrock SE
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- Wahlberg H
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- Walbrecht VM
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- Walkowiak W
- Wallangen V
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- Yamatani M
- Yamazaki T
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- Yao W-M
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- Yeletskikh I
- Yigitbasi E
- Yildirim E
- Yildiz HD
- Yorita K
- Yoshihara K
- Young C
- Young CJS
- Yu J
- Yue X
- Yuen SPY
- Zabinski B
- Zacharis G
- Zaffaroni E
- Zahreddine J
- Zaidan R
- Zaitsev AM
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- Zakharchuk N
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- Zanzi D
- Zaripovas DR
- Zeissner SV
- Zeitnitz C
- Zemaityte G
- Zeng JC
- Zenin O
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- Zhemchugov A
- Zheng Z
- Zhong D
- Zhou B
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- Zhou MS
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- Zhu CG
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- Zhu HL
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- Zhulanov V
- Zieminska D
- Zimine NI
- Zimmermann S
- Zinonos Z
- Ziolkowski M
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- Zu Theenhausen HM
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2019
- Field of study
Cross-sections of associated production of a Higgs boson decaying into bottom-quark pairs and an electroweak gauge boson, W or Z, decaying into leptons are measured as a function of the gauge boson transverse momentum. The measurements are performed in kinematic fiducial volumes defined in the `simplified template cross-section' framework. The results are obtained using 79.8 fb-1 of proton-proton collisions recorded by the ATLAS detector at the Large Hadron Collider at a centre-of-mass energy of 13 TeV. All measurements are found to be in agreement with the Standard Model predictions, and limits are set on the parameters of an effective Lagrangian sensitive to modifications of the Higgs boson couplings to the electroweak gauge bosons
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