A Comparison of the Neal-Smith and ω\u3csub\u3esp\u3c/sub\u3eΤ\u3csub\u3eθ2\u3c/sub\u3e, ς\u3csub\u3esp\u3c/sub\u3e, τ\u3csub\u3eθ\u3c/sub\u3e Flying Qualities Criteria

Aircraft pitch response is a vital element of piloted vehicle flying qualities. There has been controversy over both the form and the substance of the requirements for short-term pitch response. Currently, MIL-STD- 1797A offers six different methods for evaluating short-term pitch response. These six methods often give conflicting results. Two methods are analyzed in this thesis - the Neal-Smith criteria and the ωspΤθ2, ςsp, τθ criteria. Domains from both criteria are mapped into each other identifying regions of conflict and regions of agreement. Parametric studies are performed and evaluated for trends. Further, a real-time analysis tool for evaluating these methods is developed

Magnetic Resonance Imaging of Ethyl-nitrosourea-induced Rat Gliomas: A Model for Experimental Therapeutics of Low-grade Gliomas

Human low-grade gliomas represent a population of brain tumors that remain a therapeutic challenge. Preclinical evaluation of agents, to test their preventive or therapeutic efficacy in these tumors, requires the use of animal nobreak models. Spontaneous gliomas develop in models of chemically induced carcinogenesis, such as in the transplacental N-ethyl-N-nitrosourea (ENU) rat model. However, without the ability to detect initial tumor formation, multiplicity or to measure growth rates, it is difficult to test compounds for their interventional or preventional capabilities. In this study Fisher-334 rats, treated transplacentally with ENU, underwent magnetic resonance imaging (MRI) examination in order to evaluate this approach for detection of tumor formation and growth. ENU-induced intracranial cerebral tumors were first observable in T2-weighted images beginning at 4 months of age and grew with a mean doubling time of 0.487 ± 0.112 months. These tumors were found histologically to be predominately mixed gliomas. Two therapeutic interventions were evaluated using MRI, vitamin A (all-trans retinol palmitate, RP), as a chemopreventative agent and the anti-angiogenic drug SU-5416. RP was found to significantly delay the time to first tumor observation by one month ( P = 0.05). No differences in rates of tumor formation or growth rates were observed between control and RP-treated groups. MRI studies of rats treated with SU-5416 resulted in reduction in tumor growth rates compared to matched controls. These results show that MRI can be used to provide novel information relating to the therapeutic efficacy of agents against the ENU-induced tumor model.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/45391/1/11060_2004_Article_352248.pd

Two Strategies for the Delivery of IPTc in an Area of Seasonal Malaria Transmission in The Gambia: A Randomised Controlled Trial

Bojang and colleagues report a randomized trial showing that delivery of intermittent preventive treatment for malaria in children by village health workers is more effective than delivery by reproductive and child health trekking clinics

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

Establishment of a System Operating Characteristic for Autonomous Wide Area Search Vehicles

The optimal employment of autonomous search and destroy vehicles is addressed. The results apply to air, land, or water vehicles with 1, k, or infinite warheads. The specific scenarios considered involve an air vehicle searching a battle space for stationary targets in the presence of false targets. Encounters are modeled with uniform, Poisson, and normal distributions. Linear and circular search patterns are examined. All relevant parameters are extracted from intelligence information, the sensor performance specification, and the air vehicle performance specification. Analytic system effectiveness measures are derived using applied probability theory. The effectiveness measures derived in this dissertation handle time-varying parameters that characterize the battle space environment and the performance of the system. This allows the formulation and solution of optimization problems that maximize the probability of target attacks while at the same time constraining the probability of false target attacks. Optimal schedules for controlling sensor threshold and area coverage rate during a mission are derived and compared to the constant-parameter results. These schedules establish a system operating characteristic. An increase in system effectiveness is demonstrated when parameters are dynamically controlled during a mission. Plots depicting sensitivity to the constraint on false target attacks and sensitivity to the number of warheads are generated to give decision makers the complete trade space for either designing new systems or operating existing systems