New X-ray Detections of WNL Stars

Previous studies have demonstrated that putatively single nitrogen-type Wolf-Rayet stars (WN stars) without known companions are X-ray sources. However, almost all WN star X-ray detections so far have been of earlier WN2 - WN6 spectral subtypes. Later WN7 - WN9 subtypes (also known as WNL stars) have proved more difficult to detect, an important exception being WR 79a (WN9ha). We present here new X-ray detections of the WNL stars WR 16 (WN8h) and WR 78 (WN7h). These new results, when combined with previous detections, demonstrate that X-ray emission is present in WN stars across the full range of spectral types, including later WNL stars. The two WN8 stars observed to date (WR 16 and WR 40) show unusually low X-ray luminosities (Lx) compared to other WN stars, and it is noteworthy that they also have the lowest terminal wind speeds (v_infty). Existing X-ray detections of about a dozen WN stars reveal a trend of increasing Lx with wind luminosity Lwind = (1/2) M_dot v_infty^2, suggesting that wind kinetic energy may play a key role in establishing X-ray luminosity levels in WN stars.Comment: 20 pages, 5 figure

Chandra Detects the Rare Oxygen-type Wolf-Rayet Star WR 142 and OB Stars in Berkeley 87

We present first results of a Chandra X-ray observation of the rare oxygen-type Wolf-Rayet star WR 142 (= Sand 5 = St 3) harbored in the young, heavily-obscured cluster Berkeley 87. Oxygen type WO stars are thought to be the most evolved of the WRs and progenitors of supernovae or gamma ray bursts. As part of an X-ray survey of supposedly single Wolf-Rayet stars, we observed WR 142 and the surrounding Berkeley 87 region with Chandra ACIS-I. We detect WR 142 as a faint, yet extremely hard X-ray source. Due to weak emission, its nature as a thermal or nonthermal emitter is unclear and thus we discuss several emission mechanisms. Additionally, we report seven detections and eight non-detections by Chandra of massive OB stars in Berkeley 87, two of which are bright yet soft X-ray sources whose spectra provide a dramatic contrast to the hard emission from WR 142.Comment: To appear in the Astrophysical Journa

X-ray Emission from the FU Orionis Star V1735 Cygni

The variable star V1735 Cyg (= Elias 1-12) lies in the IC 5146 dark cloud and is a member of the class of FU Orionis objects whose dramatic optical brightenings are thought to be linked to episodic accretion. We report the first X-ray detections of V1735 Cyg and a deeply-embedded class I protostar lying 24 arcsecs to its northeast. X-ray spectra obtained with EPIC on XMM-Newton reveal very high-temperature plasma (kT > 5 keV) in both objects, but no large flares. Such hard X-ray emission is not anticipated from accretion shocks and is a signature of magnetic processes. We place these new results into the context of what is presently known about the X-ray properties of FU Orionis stars and other accreting young stellar objects.Comment: 25 pages, 6 figure

X-ray Emission from Nitrogen-Type Wolf-Rayet Stars

We summarize new X-ray detections of four nitrogen-type Wolf-Rayet (WR) stars obtained in a limited survey aimed at establishing the X-ray properties of WN stars across their full range of spectral subtypes. None of the detected stars is so far known to be a close binary. We report Chandra detections of WR 2 (WN2), WR 18 (WN4), and WR 134 (WN6), and an XMM-Newton detection of WR79a (WN9ha). These observations clearly demonstrate that both WNE and WNL stars are X-ray sources. We also discuss Chandra archive detections of the WN6h stars WR 20b, WR 24, and WR 136 and ROSAT non-detections of WR 16 (WN8h) and WR 78 (WN7h). The X-ray spectra of all WN detections show prominent emission lines and an admixture of cool (kT 2 keV) plasma. The hotter plasma is not predicted by radiative wind shock models and other as yet unidentified mechanisms are at work. Most stars show X-ray absorption in excess of that expected from visual extinction (Av), likely due to their strong winds or cold circumstellar gas. Existing data suggest a falloff in X-ray luminosity toward later WN7-9 subtypes, which have higher Lbol but slower, denser winds than WN2-6 stars. This provides a clue that wind properties may be a more crucial factor in determining emergent X-ray emission levels than bolometric luminosity.Comment: 42 pages, 5 tables, 10 figure

High-Resolution Chandra X-Ray Imaging And Spectroscopy Of The Sigma Orionis Cluster

We present results of a 90 ks Chandra X-ray observation of the young sigma Orionis cluster ( age similar to 3 Myr) obtained with the HETGS. We use the high-resolution grating spectrum and moderate-resolution CCD spectrum of the massive central star sigma Ori AB (O9.5 V + B0.5 V) to test wind shock theories of X-ray emission and also analyze the high spatial resolution zero-order ACIS-S image of the central cluster region. Chandra detected 42 X-ray sources on the primary CCD (ACIS-S3). All but five have near-IR or optical counterparts and about one-fourth are variable. Notable high-mass stellar detections are sigma Ori AB, the magnetic B star sigma Ori E, and the B5 V binary HD 37525. Most of the other detections have properties consistent with lower mass K- or M-type stars. We present the first X-ray spectrum of the unusual infrared source IRS 1, located approximate to 3 \u27\u27 north of sigma Ori AB. Its X-ray properties and elongated mid-IR morphology suggest that it is an embedded low-mass T Tauri star whose disk/envelope is being photoevaporated by sigma Ori AB. We focus on the radiative wind shock interpretation of the soft luminous X-ray emission from sigma Ori AB, but also consider possible alternatives including magnetically confined wind shocks and colliding wind shocks. Its emission lines show no significant asymmetries or centroid shifts and are moderately broadened to HWHM approximate to 264 km s(-1), or one-fourth the terminal wind speed. Forbidden lines in He-like ions are formally undetected, implying strong UV suppression. The Mg XI triplet forms in the wind acceleration zone within one stellar radius above the surface. These X-ray properties are consistent in several respects with the predictions of radiative wind shock theory for an optically thin wind, but explaining the narrow line widths presents a challenge to the theory

Association of Accelerometry-Measured Physical Activity and Cardiovascular Events in Mobility-Limited Older Adults: The LIFE (Lifestyle Interventions and Independence for Elders) Study.

BACKGROUND:Data are sparse regarding the value of physical activity (PA) surveillance among older adults-particularly among those with mobility limitations. The objective of this study was to examine longitudinal associations between objectively measured daily PA and the incidence of cardiovascular events among older adults in the LIFE (Lifestyle Interventions and Independence for Elders) study. METHODS AND RESULTS:Cardiovascular events were adjudicated based on medical records review, and cardiovascular risk factors were controlled for in the analysis. Home-based activity data were collected by hip-worn accelerometers at baseline and at 6, 12, and 24 months postrandomization to either a physical activity or health education intervention. LIFE study participants (n=1590; age 78.9±5.2 [SD] years; 67.2% women) at baseline had an 11% lower incidence of experiencing a subsequent cardiovascular event per 500 steps taken per day based on activity data (hazard ratio, 0.89; 95% confidence interval, 0.84-0.96; P=0.001). At baseline, every 30 minutes spent performing activities ≥500 counts per minute (hazard ratio, 0.75; confidence interval, 0.65-0.89 [P=0.001]) were also associated with a lower incidence of cardiovascular events. Throughout follow-up (6, 12, and 24 months), both the number of steps per day (per 500 steps; hazard ratio, 0.90, confidence interval, 0.85-0.96 [P=0.001]) and duration of activity ≥500 counts per minute (per 30 minutes; hazard ratio, 0.76; confidence interval, 0.63-0.90 [P=0.002]) were significantly associated with lower cardiovascular event rates. CONCLUSIONS:Objective measurements of physical activity via accelerometry were associated with cardiovascular events among older adults with limited mobility (summary score >10 on the Short Physical Performance Battery) both using baseline and longitudinal data. CLINICAL TRIAL REGISTRATION:URL: http://www.clinicaltrials.gov. Unique identifier: NCT01072500

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

Effect of leucine supplementation on indices of muscle damage following drop jumps and resistance exercise

The purpose of this study was to determine the effect of leucine supplementation on indices of muscle damage following eccentric-based resistance exercise. In vitro, the amino acid leucine has been shown to reduce proteolysis and stimulate protein synthesis. Twenty-seven untrained males (height 178.6±5.5 cm; body mass 77.7±13.5 kg; age 21.3±1.6 years) were randomly divided into three groups; leucine (L) (n=10), placebo (P) (n=9) and control (C) (n=8). The two experimental groups (L and P) performed 100 depth jumps from 60 cm and six sets of ten repetitions of eccentric-only leg presses. Either leucine (250 mg/kg bm) or placebo was ingested 30 min before, during and immediately post-exercise and the morning of each recovery day following exercise. Muscle function was determined by peak force during an isometric squat and by jump height during a static jump at pre-exercise (PRE) and 24, 48, 72, and 96 h post-exercise (24, 48, 72, 96 h). Additionally, at these time points each group's serum levels of creatine kinase (CK) and myoglobin (Mb) along with perceived feelings of muscle soreness were determined. None of the C group dependent variables was altered by the recurring testing procedures. Peak force was significantly decreased across all time points for both experimental groups. The L group experienced an attenuated drop in mean peak force across all post-exercise time points compared to the P group. Jump height significantly decreased from PRE for both the L and P group at 24 h and 48 h. CK and Mb was significantly elevated from PRE for both experimental groups at 24 h. Muscle soreness increased across all time points for the both the L and P group, and the L group experienced a significantly higher increase in mean muscle soreness post-exercise. Following exercise-induced muscle damage, high-dose leucine supplementation may help maintain force output during isometric contractions, however, not force output required for complex physical tasks thereby possibly limiting its ergogenic effectiveness