10 research outputs found

    Scenario Planning for Restorative Justice in Lakeland

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    Final project for URSP708: Community Planning Studio (Fall 2022). University of Maryland, College Park.This report begins with a discussion of the concept of restorative justice and the three themes that guided and organized our work — community infrastructure, housing and land use, and climate change adaptation and mitigation. Following this introduction of the three guiding themes, the report contains a summary of our analysis of existing conditions, including a review of different planning sectors, a brief history of Lakeland, and a summary of plans and policies that have influenced the course of Lakeland. The next section of the report is a summary of the findings of our various community engagement approaches, including recommendations for future best practices for the city and the Restorative Justice Commission as they continue this work. Finally, we present the three planning scenarios — Status Quo, Reform, and Revolutionary — that envision various alternative futures for Lakeland.City of College Par

    Historical thinking for senior secondary students: A collection of teaching and learning activities 2022

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    Online version of the resource: https://oercollective.caul.edu.au/historical-thinking-for-senior-secondary-students/The teaching and learning activities in this book were designed by pre-service History teachers at Deakin University, Australia. The activities cover a wide range of topics from ancient history through to early twenty-first century history and are designed to develop students' historical thinking.Attribution: Historical thinking for senior secondary students: A collection of teaching and learning activities 2022 by Rebecca Cairns (Deakin University) is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, except where otherwise noted.</p

    Redox imbalance in lung cancer of patients with underlying chronic respiratory conditions

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    Chronic respiratory diseases such as obstructive pulmonary disease (COPD) and oxidative stress may underlie lung cancer (LC). We hypothesized that the profile of oxidative and antioxidant events may differ in lung tumors and blood compartments of patients with non-small cell LC (NSCLC) with and without COPD. Redox markers (immunoblotting, ELISA, chemiluminescence, 2D electrophoresis and proteomics) were analyzed in blood samples of 17 control subjects and 80 LC patients (59 LC-COPD and 21 LC) and lung specimens (tumor and nontumor) from those undergoing thoracotomy (35 patients: 23 LC-COPD and 12 LC). As smoking history was more prevalent in LC-COPD patients, these were further analyzed post hoc as heavy and moderate smokers (cutoff, 60 pack-years). Malondialdehyde (MDA)-protein adducts and SOD1 levels were higher in tumor and nontumor samples of LC-COPD than in LC. In tumors compared with nontumors, SOD2 protein content was greater, whereas catalase levels were decreased in both LC and LC-COPD patients. Blood superoxide anion levels, protein carbonylation and nitration were greater in LC and LC-COPD patients than in the controls, and in the latter patients compared with the former. Systemic superoxide anion, protein carbonyls and nitrotyrosine above specific cutoff values best identified underlying COPD among all patients. Smoking did not influence the study results. A differential expression profile of oxidative stress markers exists in blood and, to a lesser extent, in the tumors of LC-COPD patients. These findings suggest that systemic oxidative stress and lung antioxidants (potential biomarkers) may predispose patients with chronic respiratory diseases to a higher risk for LC.This study has been supported with funding by SEPAR 2008, FUCAP 2009, FUCAP 2011, FUCAP 2012, FIS 11/02029 (FEDER), FIS 14/00713 (FEDER), SAF2011-26908, and CIBERES (Instituto de Salud Carlos III)

    Potassium channel openers and vascular smooth muscle relaxation

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