NASA ground communications

As part of the Communications Requirements and Constraints, NASA's two major Ground Data Networks were briefly described. The NASA Communication Network, called NASCOM, is the worldwide operational telecommunications system which interconnects as the tracking and telemetry acquisition sites, launch areas, mission and project control centers, data capture facilities, and network control centers in support of space flight. For the Space Station era, NASCOM plans are set for higher data rate service utilizing data packet switched technology. Increased use of fiber optics is expected in a much more diverse network topology. The second major ground network, the Program Support Communications Network (PSCN), interconnects all NASA Centers and NASA contractor locations for intercenter non-operation communications. The primary functions are to transport voice, video, data and facsimile information for intercenter coordination, and to provide user access to space science and applications data bases. For the Space Station era, PSCN plans address the significant increase in forecast requirements for science data distribution and access to the Numerical Aerodynamics Simulator, and increased use of the Video Teleconference System

High-dimensional variable selection

This paper explores the following question: what kind of statistical guarantees can be given when doing variable selection in high-dimensional models? In particular, we look at the error rates and power of some multi-stage regression methods. In the first stage we fit a set of candidate models. In the second stage we select one model by cross-validation. In the third stage we use hypothesis testing to eliminate some variables. We refer to the first two stages as "screening" and the last stage as "cleaning." We consider three screening methods: the lasso, marginal regression, and forward stepwise regression. Our method gives consistent variable selection under certain conditions.Comment: Published in at http://dx.doi.org/10.1214/08-AOS646 the Annals of Statistics (http://www.imstat.org/aos/) by the Institute of Mathematical Statistics (http://www.imstat.org

Genome-Wide Significance Levels and Weighted Hypothesis Testing

Genetic investigations often involve the testing of vast numbers of related hypotheses simultaneously. To control the overall error rate, a substantial penalty is required, making it difficult to detect signals of moderate strength. To improve the power in this setting, a number of authors have considered using weighted $p$-values, with the motivation often based upon the scientific plausibility of the hypotheses. We review this literature, derive optimal weights and show that the power is remarkably robust to misspecification of these weights. We consider two methods for choosing weights in practice. The first, external weighting, is based on prior information. The second, estimated weighting, uses the data to choose weights.Comment: Published in at http://dx.doi.org/10.1214/09-STS289 the Statistical Science (http://www.imstat.org/sts/) by the Institute of Mathematical Statistics (http://www.imstat.org