382 research outputs found
Activation of protein kinase A (PKA) by 8-Cl-cAMP as a novel approach for antileukaemic therapy
- Author
- Publication venue
- Nature Publishing Group
- Publication date
- 01/01/2004
- Field of study
Financial crises and the attainment of the SDGs: an adjusted multidimensional poverty approach
- Author
- A Antoniades
- A Chakrabarti
- A Diorio
- A Kemmler
- A Sen
- A Siddiqui
- AL Rice
- Alexander S. Antonarakis
- AM McGahan
- Andreas Antoniades
- B Dube
- BIS
- D Diz
- D Hulme
- DA Freedman
- Development Initiatives
- Development Initiatives
- DF Hendry
- DK Imana
- DL Pelletier
- F Achard
- FF Nerini
- FT Filippidis
- G Chen
- H White
- HG Barkema
- I Anderson
- I Widiarto
- ID Poloamina
- IMF
- IMF
- IMF
- Indra Widiarto
- International Council for Science
- J Alcamo
- J Fairhead
- J Piesse
- J Pretty
- J Weststrate
- JC Slocumb
- JH Mills Busa
- JI Uitto
- JN Lekakis
- JPW Scharlemann
- K Burke
- K Lee
- K Schreckenberg
- K Schulze
- KD Hoover
- KD Hoover
- KT Alexander
- L Alkema
- L Rajmil
- L Wrisdale
- M Afzal
- M Clemens
- Marcus Manuel
- MH Brenner
- Millennium Ecosystem Assessment M.E.A
- MN Shafiq
- MR Busemeyer
- MS Allahyari
- N Imai
- OECD
- P Pradhan
- P Streeten
- PG Curtis
- S Alkira
- S Alkire
- S Borenstein
- S Chen
- S Devarajan
- S Makino
- SO Rutstein
- U Al-mulali
- World Bank
- Y Zhang
- Y Zhou
- YZ Ghouali
- ZG Liu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/11/2020
- Field of study
This paper analyses the impact of financial crises on the Sustainable Development Goal of eradicating poverty. To do so, we develop an adjusted Multidimensional Poverty Framework (MPF) that includes 15 indicators that span across key poverty aspects related to income, basic needs, health, education and the environment. We then use an econometric model that allows us to examine the impact of financial crises on these indicators in 150 countries over the period 1980–2015. Our analysis produces new estimates on the impact of financial crises on poverty’s multiple social, economic and environmental aspects and equally important captures dynamic linkages between these aspects. Thus, we offer a better understanding of the potential impact of current debt dynamics on Multidimensional Poverty and demonstrate the need to move beyond the boundaries of SDG1, if we are to meet the target of eradicating poverty. Our results indicate that the current financial distress experienced by many low-income countries may reverse the progress that has been made hitherto in reducing poverty. We find that financial crises are associated with an approximately 10% increase of extreme poor in low-income countries. The impact is even stronger in some other poverty aspects. For instance, crises are associated with an average decrease of government spending in education by 17.72% in low-income countries. The dynamic linkages between most of the Multidimensional Poverty indicators, warn of a negative domino effect on a number of SDGs related to poverty, if there is a financial crisis shock. To pre-empt such a domino effect, the specific SDG target 17.4 on attaining long-term debt sustainability through coordinated policies plays a key role and requires urgent attention by the international community
Jet energy measurement with the ATLAS detector in proton-proton collisions at root s=7 TeV
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- Aad G
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdesselam A
- Abdinov O
- Abi B
- Abolins M
- Abramowicz H
- Abreu H
- Acerbi E
- Acharya BS
- Adams DL
- Addy TN
- Adelman J
- Aderholz M
- Adomeit S
- Adragna P
- Adye T
- Aefsky S
- Aguilar-Saavedra JA
- Aharrouche M
- Ahlen SP
- Ahles F
- Ahmad A
- Ahsan M
- Aielli G
- Akdogana T
- Akesson TPA
- Akimoto G
- Akimov AV
- Akiyama A
- Aktas A
- Alam MA
- Alam MS
- Albert J
- Albrand S
- Aleksa M
- Aleksandrov IN
- Alessandria F
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- Zhemchugov A
- Zheng S
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/03/2013
- Field of study
The jet energy scale and its systematic uncertainty are determined for jets measured with the ATLAS detector at the LHC in proton-proton collision data at a centre-of-mass energy of √s = 7TeV corresponding to an integrated luminosity of 38 pb-1. Jets are reconstructed with the anti-kt algorithm with distance parameters R=0. 4 or R=0. 6. Jet energy and angle corrections are determined from Monte Carlo simulations to calibrate jets with transverse momenta pT≥20 GeV and pseudorapidities {pipe}η{pipe}<4. 5. The jet energy systematic uncertainty is estimated using the single isolated hadron response measured in situ and in test-beams, exploiting the transverse momentum balance between central and forward jets in events with dijet topologies and studying systematic variations in Monte Carlo simulations. The jet energy uncertainty is less than 2. 5 % in the central calorimeter region ({pipe}η{pipe}<0. 8) for jets with 60≤pT<800 GeV, and is maximally 14 % for pT<30 GeV in the most forward region 3. 2≤{pipe}η{pipe}<4. 5. The jet energy is validated for jet transverse momenta up to 1 TeV to the level of a few percent using several in situ techniques by comparing a well-known reference such as the recoiling photon pT, the sum of the transverse momenta of tracks associated to the jet, or a system of low-pT jets recoiling against a high-pT jet. More sophisticated jet calibration schemes are presented based on calorimeter cell energy density weighting or hadronic properties of jets, aiming for an improved jet energy resolution and a reduced flavour dependence of the jet response. The systematic uncertainty of the jet energy determined from a combination of in situ techniques is consistent with the one derived from single hadron response measurements over a wide kinematic range. The nominal corrections and uncertainties are derived for isolated jets in an inclusive sample of high-pT jets. Special cases such as event topologies with close-by jets, or selections of samples with an enhanced content of jets originating from light quarks, heavy quarks or gluons are also discussed and the corresponding uncertainties are determined. © 2013 CERN for the benefit of the ATLAS collaboration
Measurement of the inclusive and dijet cross-sections of b-jets in pp collisions at sqrt(s) = 7 TeV with the ATLAS detector
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- van Eldik N
- van Gemmeren P
- van Kesteren Z
- van Vulpen I
- Vandelli W
- Vandoni G
- Vaniachine A
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- Vannucci F
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- Varnes EW
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- Vassilakopoulos VI
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- Vermeulen JC
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- Vorobiev AP
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- Vuillermet R
- Vukotic I
- Wagner P
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- Wakabayashi J
- Walbersloh J
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- Weingarten J
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- Werner M
- Werner P
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- Wessels M
- Whalen K
- Wheeler-Ellis SJ
- Whitaker SP
- White A
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- Whitehead SR
- Whiteson D
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- Wicek F
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- Wickens FJ
- Wiedenmann W
- Wielers M
- Wienemann P
- Wiglesworth C
- Wiik LAM
- Wildauer A
- Wildt MA
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- Wilkens HG
- Will JZ
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- Williams HH
- Willis W
- Willocq S
- Wilson A
- Wilson JA
- Wilson MG
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- Winkelmann S
- Winklmeier F
- Wittgen M
- Wolter MW
- Wolters H
- Wooden G
- Wosiek BK
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- Woudstra MJ
- Wraight K
- Wright C
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- Wu SL
- Wu X
- Wu Y
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- Wunstorf R
- Wynne BM
- Xaplanteris L
- Xella S
- Xie S
- Xie Y
- Xu C
- Xu D
- Xu G
- Yabsley B
- Yagci KD
- Yamada M
- Yamamoto A
- Yamamoto K
- Yamamoto S
- Yamamura T
- Yamaoka J
- Yamazaki T
- Yamazaki Y
- Yan Z
- Yang H
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- Yang UK
- Yang Y
- Yang Y
- Yang Z
- Yanush S
- Yao W-M
- Yao Y
- Yasu Y
- Ye J
- Ye S
- Yildiz HD
- Yilmaz M
- Yoosoofmiya R
- Yorita K
- Yoshida R
- Young C
- Youssef S
- Yu D
- Yu J
- Yu J
- Yuan L
- Yurkewicz A
- Zaets VG
- Zaidan R
- Zaitsev AM
- Zajacova Z
- Zalite YK
- Zanello L
- Zarzhitsky P
- Zaytsev A
- Zdrazil M
- Zeitnitz C
- Zeller M
- Zema PF
- Zemla A
- Zendler C
- Zenin AV
- Zenin O
- Zenis T
- Zenonos Z
- Zenz S
- Zerwas D
- Zhan Z
- Zhang D
- Zhang H
- Zhang J
- Zhang X
- Zhang Z
- Zhao L
- Zhao T
- Zhao Z
- Zhemchugov A
- Zheng S
- Zhong J
- Zhou B
- Zhou N
- Zhou Y
- Zhu CG
- Zhu H
- Zhu Y
- Zhuang X
- Zhuravlov V
- Zieminska D
- Zilka B
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Ziolkowski M
- Zitoun R
- Zivkovic L
- Zmouchko VV
- Zobernig G
- Zoccoli A
- Zolnierowski Y
- Zsenei A
- zur Nedden M
- Zutshi V
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 31/12/2010
- Field of study
The inclusive and dijet production cross-sections have been measured for jets
containing b-hadrons (b-jets) in proton-proton collisions at a centre-of-mass
energy of sqrt(s) = 7 TeV, using the ATLAS detector at the LHC. The
measurements use data corresponding to an integrated luminosity of 34 pb^-1.
The b-jets are identified using either a lifetime-based method, where secondary
decay vertices of b-hadrons in jets are reconstructed using information from
the tracking detectors, or a muon-based method where the presence of a muon is
used to identify semileptonic decays of b-hadrons inside jets. The inclusive
b-jet cross-section is measured as a function of transverse momentum in the
range 20 < pT < 400 GeV and rapidity in the range |y| < 2.1. The bbbar-dijet
cross-section is measured as a function of the dijet invariant mass in the
range 110 < m_jj < 760 GeV, the azimuthal angle difference between the two jets
and the angular variable chi in two dijet mass regions. The results are
compared with next-to-leading-order QCD predictions. Good agreement is observed
between the measured cross-sections and the predictions obtained using POWHEG +
Pythia. MC@NLO + Herwig shows good agreement with the measured bbbar-dijet
cross-section. However, it does not reproduce the measured inclusive
cross-section well, particularly for central b-jets with large transverse
momenta.Comment: 10 pages plus author list (21 pages total), 8 figures, 1 table, final
version published in European Physical Journal
Simultaneous Analysis of Proteome, Phospho- and Glycoproteome of Rat Kidney Tissue with Electrostatic Repulsion Hydrophilic Interaction Chromatography
- Author
- AJ Alpert
- BA Ballif
- C Temporini
- CD Calvano
- CM Williams
- CP Albuquerque
- CS Gan
- DH Dube
- EL George
- F Gnad
- G Han
- H Zhang
- H Zhang
- HA Buller
- I Cuchillo-Ibanez
- ID Campbell
- J Rush
- JE Elias
- JV Olsen
- JV Olsen
- M Ashburner
- M Dorn
- MP Washburn
- MR Larsen
- MV Bennetzen
- P Cohen
- P Hao
- P Hu
- PG Moon
- Piliang Hao
- R Apweiler
- R Schiess
- RH Kehlenbach
- RW Tilghman
- S Carbon
- S Feng
- S Ito
- SA Beausoleil
- SB Ficarro
- SH Heo
- Siu Kwan Sze
- T Guo
- T Hunter
- T Miida
- T Pawson
- TB Shea
- Tiannan Guo
- U Lewandrowski
- ULK Lewandrowski
- W Morelle
- Y Deng
- Y Ren
- Y. Adam Yuan
- YB Wu
- Z Wang
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2011
- Field of study
Protein post-translational modifications (PTMs) are regulated separately from protein expression levels. Thus, simultaneous characterization of the proteome and its PTMs is pivotal to an understanding of protein regulation, function and activity. However, concurrent analysis of the proteome and its PTMs by mass spectrometry is a challenging task because the peptides bearing PTMs are present in sub-stoichiometric amounts and their ionization is often suppressed by unmodified peptides of high abundance. We describe here a method for concurrent analysis of phosphopeptides, glycopeptides and unmodified peptides in a tryptic digest of rat kidney tissue with a sequence of ERLIC and RP-LC-MS/MS in a single experimental run, thereby avoiding inter-experimental variation. Optimization of loading solvents and elution gradients permitted ERLIC to be performed with totally volatile solvents. Two SCX and four ERLIC gradients were compared in details, and one ERLIC gradient was found to perform the best, which identified 2929 proteins, 583 phosphorylation sites in 338 phosphoproteins and 722 N-glycosylation sites in 387 glycoproteins from rat kidney tissue. Two hundred low-abundance proteins with important functions were identified only from the glyco- or phospho-subproteomes, reflecting the importance of the enrichment and separation of modified peptides by ERLIC. In addition, this strategy enables identification of unmodified and corresponding modified peptides (partial phosphorylation and N-glycosylation) from the same protein. Interestingly, partially modified proteins tend to occur on proteins involved in transport. Moreover, some membrane or extracellular proteins, such as versican core protein and fibronectin, were found to have both phosphorylation and N-glycosylation, which may permit an assessment of the potential for cross talk between these two vital PTMs and their roles in regulation
Transient Responses to NOTCH and TLX1/HOX11 Inhibition in T-Cell Acute Lymphoblastic Leukemia/Lymphoma
- Author
- A Wilson
- AA Ferrando
- AA Ferrando
- AP Weng
- AP Weng
- BJ Thompson
- BM Owens
- C Graux
- C Spaulding
- CJ Fryer
- CW Roberts
- DD Dudley
- Erica A. Lehotzky
- G Della Gatta
- I Lahortiga
- I Maillard
- I Riz
- I Riz
- ID Dube
- J Bergeron
- J Kwan
- J O'Neil
- JC Aster
- JH van Es
- K Cullion
- K De Keersmaecker
- K De Keersmaecker
- Lesley A. Rakowski
- M Hatano
- M Kleppe
- MA Kennedy
- Marc Tjwa
- Mark Y. Chiang
- MJ Malecki
- MR Hough
- MY Chiang
- MY Chiang
- MY Chiang
- N Labrecque
- NJ Donato
- P Van Vlierberghe
- R Forster
- R Kopan
- RG Hawley
- S Gonzalez-Garcia
- SM Chan
- T Palomero
- T Palomero
- TN Dear
- V Asnafi
- V Tosello
- VM Sharma
- WK Greene
- X Su
- YW Lin
- Publication venue
- Public Library of Science
- Publication date
- 01/02/2011
- Field of study
To improve the treatment strategies of T-cell acute lymphoblastic leukemia/lymphoma (T-ALL), further efforts are needed to identify therapeutic targets. Dysregulated expression of HOX-type transcription factors occurs in 30–40% of cases of T-ALL. TLX1/HOX11 is the prototypical HOX-type transcription factor. TLX1 may be an attractive therapeutic target because mice that are deficient in TLX1 are healthy. To test this possibility, we developed a conditional doxycycline-regulated mouse model of TLX1-initiated T-ALL. TLX1 induced T-ALL after ∼5–7 months with penetrance of 15–60%. Similar to human TLX1-type T-ALLs, the TLX1-induced tumors were arrested at the cortical stage of T-cell development and acquired activating NOTCH1 mutations. Inhibition of NOTCH signaling abrogated growth of cell lines derived from the TLX1-induced tumors. NOTCH inhibition also transiently delayed leukemia progression in vivo. Suppression of TLX1 expression slowed the growth of TLX1 tumor cell lines. Suppression of TLX1 in vivo also transiently delayed leukemia progression. We have shown that TLX1 functions as a T-cell oncogene that is active during both the induction and the maintenance phases of leukemia. However, the effect of suppressing NOTCH or TLX1 was transient. The tumors eventually “escaped” from inhibition. These data imply that the biological pathways and gene sets impacted by TLX1 and NOTCH have largely lost their importance in the fully established tumor. They have been supplanted by stronger oncogenic pathways. Although TLX1 or NOTCH inhibitors may not be effective as single agents, they may still contribute to combination therapy for TLX1-driven acute leukemia
Search for Dark Matter and Supersymmetry with a Compressed Mass Spectrum in the Vector Boson Fusion Topology in Proton-Proton Collisions at root s=8 TeV
- Author
- Aarrestad TK
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abdulsalam A
- Abu Zeid S
- Ackert A
- Acosta D
- Acosta JG
- Adair A
- Adam W
- Adams JR
- Adams MR
- Adams T
- Adiguzel A
- Adzic P
- Agapitos A
- Aggleton R
- Agram J-L
- Ahmad A
- Ahmad M
- Ahmad M
- Ahmed I
- Ahuja S
- Akchurin N
- Akgun B
- Al-bataineh A
- Albergo S
- Albrow M
- Alcaraz Maestre J
- Aldaya Martin M
- Alderweireldt S
- Aldá Júnior WL
- Aleksandrov A
- Alexander J
- Alimena J
- Almond J
- Alunni Solestizi L
- Alverson G
- Alves FL
- Alves GA
- Alyari M
- Amapane N
- Amsler C
- Anagnostou G
- Anderson D
- Anderson I
- Andrea J
- Andreev V
- Andreev Yu
- Andrews MB
- Androsov K
- Anelli C
- Antonelli L
- Antropov I
- Antunovic Z
- Apanasevich L
- Apollinari G
- Apresyan A
- Apyan A
- Arcaro D
- Arcidiacono R
- Arenton MW
- Argiro S
- Arneodo M
- Asavapibhop B
- Asawatangtrakuldee C
- Asilar E
- Asin I
- Askew A
- Ata M
- Attikis A
- Aubin A
- Auffray E
- Autermann C
- Auzinger G
- Avdeeva E
- Avery P
- Avetisyan A
- Avila C
- Awad A
- Azarkin M
- Azhgirey I
- Aziz T
- Azzi P
- Azzolini V
- Azzurri P
- Baarmand MM
- Baber M
- Bacchetta N
- Bachmair F
- Bachtis M
- Baden A
- Baffioni S
- Bagliesi G
- Bahinipati S
- Baillon P
- Bainbridge R
- Bakhshiansohi H
- Bakirci MN
- Ball AH
- Ball F
- Ban Y
- Banerjee S
- Banerjee S
- Bansal S
- Barbagli G
- Barberis E
- Barbieri R
- Bargassa P
- Baringer P
- Barker A
- Barnes VE
- Barney D
- Baron O
- Barone L
- Barria P
- Bartek R
- Barth C
- Bartosik N
- Bartók M
- Baskakov A
- Battilana C
- Baty A
- Bauerdick LAT
- Baumgartel D
- Baus C
- Bayshev I
- Bean A
- Beauceron S
- Beaudette F
- Beck L
- Beernaert K
- Behera PK
- Behnamian H
- Behnke O
- Behrens U
- Bein S
- Beirão Da Cruz E Silva C
- Belchior Batista Das Chagas E
- Belforte S
- Beliy N
- Belknap DA
- Bell KW
- Bellan R
- Belloni A
- Beluffi C
- Belyaev A
- Belyaev A
- Benato L
- Bencze G
- Bendavid J
- Benedetti D
- Benelli G
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- Benussi L
- Benvenuti AC
- Beranek S
- Beretvas A
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- Berger J
- Beri SB
- Bernardes CA
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- Bernet C
- Berry D
- Berry E
- Berryhill J
- Bertl W
- Besancon M
- Betchart B
- Betts RR
- Bhandari R
- Bhardwaj A
- Bhat PC
- Bhatnagar V
- Bhattacharya R
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- Bhattacharya S
- Bhawandeep U
- Bhopatkar V
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- Chen HS
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- Chen Z
- Chenarani S
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- Cherepanov V
- Chertok M
- Cheung HWK
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- Ciangottini D
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- Ciocci MA
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- Citron M
- Cittolin S
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- Civinini C
- Claes DR
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- Clerbaux B
- Cockerill DJA
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- Codispoti G
- Colafranceschi S
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- Contardo D
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- Conway J
- Conway R
- Cooper SI
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- Corpe L
- Correa Martins Junior M
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- Costanza F
- Coubez X
- Couderc F
- Coughlan JA
- Courbon B
- Cousins R
- Covarelli R
- Cowden C
- Cox B
- Cox PT
- Creanza D
- Cremonesi M
- Cristella L
- Cuevas J
- Cuffiani M
- Cumalat JP
- Curras E
- Curry D
- Cussans D
- Custódio A
- Cutts D
- Czellar S
- Da Costa EM
- Da Silveira GG
- Dabrowski A
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- Dahmes B
- Dalchenko M
- Dallavalle GM
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- Damarseckin S
- Damgov J
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- Dilsiz K
- Dimitrov A
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- Dishaw A
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- Dosselli U
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- Dragoiu C
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- Dubinin M
- Duchardt D
- Dudenas V
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- Dugad S
- Duggan D
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- Dumanoglu I
- Dunne P
- Dupont N
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- Durkin LS
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- D’Agnolo RT
- D’Alessandro R
- D’Alfonso M
- d’Enterria D
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- D’imperio G
- Eckerlin G
- Ecklund KM
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- Eerola P
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- Elgammal S
- Eller P
- Elliott-Peisert A
- Ellison J
- Elmer P
- Elumakhov D
- Elvira VD
- Elwood A
- Eminizer N
- Endres M
- Eno SC
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- Erbacher R
- Erdmann M
- Erdmann W
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- Erdweg S
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- Ershov A
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- Escalante Del Valle A
- Esch T
- Eshaq Y
- Eskandari Tadavani E
- Esposito M
- Etesami SM
- Eusebi R
- Evangelou I
- Evans A
- Evdokimov O
- Everaerts P
- Fabbri F
- Fabbri F
- Fabbro B
- Fabozzi F
- Faccioli P
- Fagot A
- Fahim A
- Fan J
- Fanfani A
- Fang W
- Fangmeier C
- Fanò L
- Fartoukh S
- Fasanella D
- Fasanella G
- Faulkner J
- Faure JL
- Favaro C
- Favart L
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- Publication venue
- Publication date
- 01/01/2016
- Field of study
Peer reviewe
Measurement of the cross-section for b-jets produced in association with a Z boson at root s=7 TeV with the ATLAS detector ATLAS Collaboration
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdesselam A
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- Winkelmann S
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- Xie Y
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- Xu D
- Xu G
- Yabsley B
- Yacoob S
- Yagci KD
- Yamada M
- Yamaguchi H
- Yamamoto A
- Yamamoto K
- Yamamoto S
- Yamamura T
- Yamanaka T
- Yamaoka J
- Yamazaki T
- Yamazaki Y
- Yan Z
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- Yang UK
- Yang Y
- Yang Y
- Yang Z
- Yanush S
- Yao Y
- Yasu Y
- Ye J
- Ye S
- Yildizb HD
- Yilmaz M
- Yoosoofmiya R
- Yorita K
- Yoshida R
- Young C
- Youssef S
- Yu D
- Yu J
- Yu J
- Yuan L
- Yurkewicz A
- Zaets VG
- Zaidan R
- Zaitsev AM
- Zajacova Z
- Zalite YK
- Zanello L
- Zarzhitsky P
- Zaytsev A
- Zeitnitz C
- Zeller M
- Zeman M
- Zemla A
- Zendler C
- Zenin O
- Zenis T
- Zenonos Z
- Zenz S
- Zerwas D
- Zhan Z
- Zhang D
- Zhang H
- Zhang J
- Zhang X
- Zhang Z
- Zhao L
- Zhao T
- Zhao Z
- Zhemchugov A
- Zheng S
- Zhong J
- Zhou B
- Zhou N
- Zhou Y
- Zhu CG
- Zhu H
- Zhu J
- Zhu Y
- Zhuang X
- Zhuravlov V
- Zieminska D
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Ziolkowski M
- Zitoun R
- Zivkovic L
- Zmouchko VV
- Zobernig G
- Zoccoli A
- Zolnierowski Y
- Zsenei A
- zur Nedden M
- Zutshi V
- Zwalinski L
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2011
- Field of study
A measurement is presented of the inclusive cross-section for b-jet production in association with a Z boson in pp collisions at a centre-of-mass energy of root s = 7 TeV. The analysis uses the data sample collected by the ATLAS experiment in 2010, corresponding to an integrated luminosity of approximately 36 pb(-1). The event selection requires a Z boson decaying into high P-T electrons or muons, and at least one b-jet, identified by its displaced vertex, with transverse momentum p(T) > 25 GeV and rapidity vertical bar y vertical bar < 2.1. After subtraction of background processes, the yield is extracted from the vertex mass distribution of the candidate b-jets. The ratio of this cross-section to the inclusive Z cross-section (the average number of b-jets per Z event) is also measured. Both results are found to be in good agreement with perturbative QCD predictions at next-to-leading order
Species-Specific Therapy of Acute Lymphoid Leukemia
- Author
- AA Sandberg
- AD Luster
- BL Dowell
- BM Camitta
- C Patte
- C-H Pui
- CA Hurwitz
- CM Croce
- CM Rubin
- CT Denny
- D Pinkel
- D Pinkel
- D Pinkel
- DL Williams
- F Katz
- F Lampert
- FM Schabel Jr
- G Flandrin
- GK Rivera
- HJ Feickert
- ID Dube
- J Erikson
- J Jolivet
- J Pedersen-Bjergaard
- JD Rowley
- JM Birch
- K Stam
- L Sen
- LR Finger
- LS Frankel
- M Amylon
- MH Goyns
- MP Sullivan
- PG Steinherz
- R Kurzrock
- R Sansone
- RJA Aur
- RJA Aur
- RP Gale
- RW Miller
- S Farber
- S Farber
- S Sunami
- SA Stass
- SC Raimondi
- SE Lipshultz
- SJ Lauer
- TL Yang-Feng
- WM Crist
- WW Zuelzer
- Y Kaneko
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1989
- Field of study
Forty years ago, Farber and associates described temporary remissions of acute leukemia in children produced by folic acid antagonists [13]. This ignited the hope that this most frequent and always fatal childhood cancer might be curable by drugs. Twenty years ago, Aur and as-sociates completed accession of patients to total therapy study V, the first treat-ment protocol to result in 50 % cure of acute lymphoid leukemia (ALL) [3]. Their results stand 20 years later (Fig. 1), and have been reproduced throughout the world in many thousands of children [6]. More important, recent national vital statistics of the United States and the United Kingdom indicate a 50 % reduc-tion in childhood leukemia mortality [4, 29]. Further, the cured children generally enjoy a normal life-style without need for medication. In the past 20 years, efforts have been directed at improving the cure rate of ALL while simplifying curative treat-ment, reducing its side effects, and im-proving its availability and accessibility. In a Stohlman Lecture at Wilsede 10 years ago the following statement was made [32]:- The most significant opportunity for improving the treatment of acute lymphoid leukemia in the past five years has been its biological and clini-cal classification by immunological cell surface markers. This allows spe-cies identification of the leukemia cells, the first step toward developing specific cytocidal or cytostatic therapy
Search for dark matter produced in association with a single top quark or a top quark pair in proton-proton collisions at s=13 TeV
- Author
- Aarrestad TK
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullah WAT Wan
- Abdullin S
- Abdulsalam A
- Abercrombie D
- Abu Zeid S
- Ackert A
- Acosta D
- Acosta JG
- Adam W
- Adams MR
- Adams T
- Adzic P
- Afanasiev S
- Agapitos A
- Agaras MN
- Aggleton R
- Agram J-L
- Ahmad A
- Ahmad M
- Ahmad M
- Ahmed I
- Ahuja S
- Akbiyik M
- Akchurin N
- Akgun B
- Al-Bataineh A
- Albajar C
- Albergo S
- Albert A
- Albrow M
- Alcaraz Maestre J
- Aleksandrov A
- Alexander J
- Alhusseini M
- Ali MAB Md
- Alimena J
- Allen B
- Almond J
- Alvarez Fernandez A
- Alvarez JD Ruiz
- Alverson G
- Alves FL
- Alves GA
- Alyari M
- Amapane N
- Ambrogi F
- Amendola C
- Amin N
- Amsler C
- Anagnostou G
- Anampa K Hurtado
- Anderson D
- Andrea J
- Andreev V
- Andreev Yu
- Andrews MB
- Androsov K
- Angioni L Pinna
- Antonelli L
- Antropov I
- Antunovic Z
- Apanasevich L
- Apollinari G
- Apresyan A
- Apyan A
- Araujo M
- Arcaro D
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- Publication venue
- Publication date
- 01/01/2019
- Field of study
A search has been performed for heavy resonances decaying to ZZ or ZW in 2l2q final states, with two charged leptons (l = e, mu) produced by the decay of a Z boson, and two quarks produced by the decay of a W or Z boson. The analysis is sensitive to resonances with masses in the range from 400 to 4500 GeV. Two categories are defined based on the merged or resolved reconstruction of the hadronically decaying vector boson, optimized for high- and low-mass resonances, respectively. The search is based on data collected during 2016 by the CMS experiment at the LHC in proton-proton collisions with a center-of-mass energy of root s = 13 TeV, corresponding to an integrated luminosity of 35.9 fb(-1). No excess is observed in the data above the standard model background expectation. Upper limits on the production cross section of heavy, narrow spin-1 and spin-2 resonances are derived as a function of the resonance mass, and exclusion limits on the production of W' bosons and bulk graviton particles are calculated in the framework of the heavy vector triplet model and warped extra dimensions, respectively.A search has been performed for heavy resonances decaying to ZZ or ZW in 2l2q final states, with two charged leptons (l = e, mu) produced by the decay of a Z boson, and two quarks produced by the decay of a W or Z boson. The analysis is sensitive to resonances with masses in the range from 400 to 4500 GeV. Two categories are defined based on the merged or resolved reconstruction of the hadronically decaying vector boson, optimized for high- and low-mass resonances, respectively. The search is based on data collected during 2016 by the CMS experiment at the LHC in proton-proton collisions with a center-of-mass energy of root s = 13 TeV, corresponding to an integrated luminosity of 35.9 fb(-1). No excess is observed in the data above the standard model background expectation. Upper limits on the production cross section of heavy, narrow spin-1 and spin-2 resonances are derived as a function of the resonance mass, and exclusion limits on the production of W' bosons and bulk graviton particles are calculated in the framework of the heavy vector triplet model and warped extra dimensions, respectively.A search for dark matter produced in association with top quarks in proton-proton collisions at a center-of-mass energy of 13 TeV is presented. The data set used corresponds to an integrated luminosity of 35.9 fb(-1) recorded with the CMS detector at the LHC. Whereas previous searches for neutral scalar or pseudoscalar mediators considered dark matter production in association with a top quark pair only, this analysis also includes production modes with a single top quark. The results are derived from the combination of multiple selection categories that are defined to target either the single top quark or the top quark pair signature. No significant deviations with respect to the standard model predictions are observed. The results are interpreted in the context of a simplified model in which a scalar or pseudoscalar mediator particle couples to a top quark and subsequently decays into dark matter particles. Scalar and pseudoscalar mediator particles with masses below 290 and 300 GeV, respectively, are excluded at 95% confidence level, assuming a dark matter particle mass of 1 GeV and mediator couplings to fermions and dark matter particles equal to unity.Peer reviewe
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