665 research outputs found
Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015
- Author
- Aasvang GM
- Abajobir AA
- Abate KH
- Abbafati C
- Abbas KM
- Abd-Allah F
- Abdulle AM
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- Abu-Raddad LJ
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- Adebiyi AO
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- Alemu ZA
- Alexander LT
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- Beardsley J
- Beatriz Heredia-Pi I
- Beatriz Lawrynowicz AE
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- Zipkin B
- Zodpey S
- Zuhlke LJ
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2016
- Field of study
SummaryBackground The Global Burden of Diseases, Injuries, and Risk Factors Study 2015 provides an up-to-date synthesis of the evidence for risk factor exposure and the attributable burden of disease. By providing national and subnational assessments spanning the past 25 years, this study can inform debates on the importance of addressing risks in context. Methods We used the comparative risk assessment framework developed for previous iterations of the Global Burden of Disease Study to estimate attributable deaths, disability-adjusted life-years (DALYs), and trends in exposure by age group, sex, year, and geography for 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks from 1990 to 2015. This study included 388 risk-outcome pairs that met World Cancer Research Fund-defined criteria for convincing or probable evidence. We extracted relative risk and exposure estimates from randomised controlled trials, cohorts, pooled cohorts, household surveys, census data, satellite data, and other sources. We used statistical models to pool data, adjust for bias, and incorporate covariates. We developed a metric that allows comparisons of exposure across risk factors—the summary exposure value. Using the counterfactual scenario of theoretical minimum risk level, we estimated the portion of deaths and DALYs that could be attributed to a given risk. We decomposed trends in attributable burden into contributions from population growth, population age structure, risk exposure, and risk-deleted cause-specific DALY rates. We characterised risk exposure in relation to a Socio-demographic Index (SDI). Findings Between 1990 and 2015, global exposure to unsafe sanitation, household air pollution, childhood underweight, childhood stunting, and smoking each decreased by more than 25%. Global exposure for several occupational risks, high body-mass index (BMI), and drug use increased by more than 25% over the same period. All risks jointly evaluated in 2015 accounted for 57·8% (95% CI 56·6–58·8) of global deaths and 41·2% (39·8–42·8) of DALYs. In 2015, the ten largest contributors to global DALYs among Level 3 risks were high systolic blood pressure (211·8 million [192·7 million to 231·1 million] global DALYs), smoking (148·6 million [134·2 million to 163·1 million]), high fasting plasma glucose (143·1 million [125·1 million to 163·5 million]), high BMI (120·1 million [83·8 million to 158·4 million]), childhood undernutrition (113·3 million [103·9 million to 123·4 million]), ambient particulate matter (103·1 million [90·8 million to 115·1 million]), high total cholesterol (88·7 million [74·6 million to 105·7 million]), household air pollution (85·6 million [66·7 million to 106·1 million]), alcohol use (85·0 million [77·2 million to 93·0 million]), and diets high in sodium (83·0 million [49·3 million to 127·5 million]). From 1990 to 2015, attributable DALYs declined for micronutrient deficiencies, childhood undernutrition, unsafe sanitation and water, and household air pollution; reductions in risk-deleted DALY rates rather than reductions in exposure drove these declines. Rising exposure contributed to notable increases in attributable DALYs from high BMI, high fasting plasma glucose, occupational carcinogens, and drug use. Environmental risks and childhood undernutrition declined steadily with SDI; low physical activity, high BMI, and high fasting plasma glucose increased with SDI. In 119 countries, metabolic risks, such as high BMI and fasting plasma glucose, contributed the most attributable DALYs in 2015. Regionally, smoking still ranked among the leading five risk factors for attributable DALYs in 109 countries; childhood underweight and unsafe sex remained primary drivers of early death and disability in much of sub-Saharan Africa. Interpretation Declines in some key environmental risks have contributed to declines in critical infectious diseases. Some risks appear to be invariant to SDI. Increasing risks, including high BMI, high fasting plasma glucose, drug use, and some occupational exposures, contribute to rising burden from some conditions, but also provide opportunities for intervention. Some highly preventable risks, such as smoking, remain major causes of attributable DALYs, even as exposure is declining. Public policy makers need to pay attention to the risks that are increasingly major contributors to global burden. Funding Bill & Melinda Gates Foundation
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- Author
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- Villella I
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- Yilmaz Y
- Yohay R
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- Zeuner WD
- Zeyrek M
- Zhang J
- Zhang Z
- Zheng Y
- Zhokin A
- Zhu B
- Zhu RY
- Zhukov V
- Zhukova V
- Zielinski M
- Zito G
- Zou W
- Zucchetta A
- Zumerle G
- Zuranski A
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2012
- Field of study
A search for new physics is performed in events with two same-sign isolated
leptons, hadronic jets, and missing transverse energy in the final state. The
analysis is based on a data sample corresponding to an integrated luminosity of
4.98 inverse femtobarns produced in pp collisions at a center-of-mass energy of
7 TeV collected by the CMS experiment at the LHC. This constitutes a factor of
140 increase in integrated luminosity over previously published results. The
observed yields agree with the standard model predictions and thus no evidence
for new physics is found. The observations are used to set upper limits on
possible new physics contributions and to constrain supersymmetric models. To
facilitate the interpretation of the data in a broader range of new physics
scenarios, information on the event selection, detector response, and
efficiencies is provided.Comment: Published in Physical Review Letter
Effects of proactive population-based nephrologist oversight on progression of chronic kidney disease: a retrospective control analysis
- Author
- AC Feldstein
- Alan Lau
- AS Levey
- AS Levey
- AS Levey
- AS Levey
- BJ Lee
- Brian Lee
- C Black
- C Jones
- D Blumenthal
- D Blumenthal
- Di Meng
- FJ Crosson
- HR Martinez-Ramirez
- J Coresh
- LA Orlando
- Linda Radler
- Marianne Turley
- MJ Landray
- N Altemtam
- SC Chen
- SI Hallan
- SM Grundy
- SV Giannelli
- T Yamashita
- Terhilda Garrido
- United States Renal Data System
- United States Renal Data System
- WF Keane
- WW Brown
- XL Yang
- Yvonne Zhou
- YY Zhou
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Defining the causes of sporadic Parkinson’s disease in the global Parkinson’s genetics program (GP2)
- Author
- Aasly JO
- Ahmad-Annuar A
- Akpalu A
- Albin R
- Alcalay R
- Alvarez I
- Amod F
- Amouri R
- Anderson TJ
- Antar T
- Arboleda G
- Atadzhanov M
- Avenali M
- Awad PS
- Azmin S
- Bale C
- Bandres-Ciga S
- Bardien S
- Basak AN
- Beach T
- Beyer K
- Blauwendraat C
- Borgohain R
- Brice A
- Bustamante ML
- Cakmak OO
- Camargos S
- Carr J
- Carroll C
- Casey B
- Chahine LM
- Chan GH-F
- Chan P
- Chan P
- Chana P
- Chen H
- Cheung NY-F
- Chowdhury S
- Comart C
- Cornejo-Olivas M
- Corvol J-C
- Cruchaga C
- Cubo E
- Dadiotis E
- Dagklis I
- Dean M
- del Rio MJ
- Dey S
- Doquenia ML
- Dumanis S
- El-Sadig S
- Ellis M
- Ertan S
- Espay A
- Faghri F
- Fang Z-H
- Fiske B
- Fon EA
- Fon T
- Foo JN
- Foroud T
- Funayama M
- Galleguillos BP
- Gasser T
- Gatto EM
- Genc G
- Groppa S
- Grosset D
- Guo J
- Hadjigorgiou G
- Hall D
- Hardy J
- Hattori N
- Hernandez A
- Hernandez D
- Hernandez DG
- Hoenicka J
- Hoglinger G
- Hopfner F
- Houlden H
- Hunter J
- Iakovenko E
- Ibanez L
- Illarionova A
- Inca-Martinez M
- Ip N
- Iwaki H
- Jankovic J
- Jasaitye S
- Jasaityte S
- Jeon B
- Jonas C
- Joubert J
- Junker J
- Kaishibayeva G
- Kaiyrzhanov R
- Kamel WA
- Karimova A
- Kauffman M
- Khachatryan S
- Kieburtz K
- Kim JJ
- Kim YJ
- Kishore A
- Klein C
- Koks S
- Koretsky M
- Kp D
- Krack P
- Kruger R
- Kuhl M
- Kukkle PL
- Kumar K
- Kung P-J
- Lange LM
- Leonard H
- Levine K
- Levine KS
- Lewis PA
- Lim S-Y
- Lin C-H
- Lohmann K
- Louie N
- Love S
- Lubbe S
- Luo W
- Madoev H
- Makarious MB
- Marek K
- Markopoulou K
- Marsili L
- Martinez-Carrasco A
- Martinez-Ramirez D
- Mata IF
- Medina A
- Mencacci NE
- Miranda M
- Mohamed W
- Mok KY
- Mollenhauer B
- Monchi O
- Morris HR
- Mubarak BA
- Murad NAA
- Murphy K
- Nalls MA
- Nguyen D
- Nguyen T
- Norlinah MI
- Noyce A
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- O'Grady A
- Obese V
- Ojha R
- Ojo O
- Okubadejo N
- Okunoye O
- Olguin P
- Orozco J
- Pal P
- Pantazis CB
- Parnetti L
- Pastor P
- Perinan MT
- Pihlstrom L
- Pitcher TL
- Puckelwartz MJ
- Quattrone A
- Rajan R
- Renteria ME
- Reyes-Perez P
- Richer M
- Rieder C
- Riley E
- Rizig M
- Rodriguez-Violante M
- Rosales R
- Ruffrage L
- Salama M
- Salari M
- Sanyaolu A
- Sarmiento IJK
- Sassi SB
- Schapira A
- Schirinzi T
- Schrag A
- Schumacher-Schuh AF
- Screven L
- Screven LA
- Serrano GE
- Shambetova C
- Shang H
- Sharma M
- Shepherd CE
- Sherer T
- Shiamim E
- Shiraishi T
- Shulman J
- Shulman L
- Siddiqi B
- Singleton AB
- Sobering AK
- Solle J
- Solle JC
- Song Y
- Stafford EJ
- Stamelou M
- Stefanis L
- Stott S
- Tan AH
- Tan E-K
- Tan M
- Tan MMX
- Tang B
- Tarnanas I
- Tavadyan Z
- Tay YW
- Towns C
- Trinh J
- Tserensodnom B
- Tumas V
- Umair M
- Ur-Rehman S
- Valente EM
- Vinuela A
- Vitale D
- Vollstedt E-J
- Walker R
- Wegel C
- Wegel CE
- Weil R
- Westenberger A
- Williams N
- Williamson J
- Wood N
- Wu H-C
- Wu R-M
- Wu Y
- Xie T
- Xiromerisiou G
- Zewde YZ
- Zhou X
- Zimprich A
- Zweier C
- Publication venue
- Springer Nature
- Publication date
- Field of study
\ua9 2023, Springer Nature Limited. The Global Parkinson’s Genetics Program (GP2) will genotype over 150,000 participants from around the world, and integrate genetic and clinical data for use in large-scale analyses to dramatically expand our understanding of the genetic architecture of PD. This report details the workflow for cohort integration into the complex arm of GP2, and together with our outline of the monogenic hub in a companion paper, provides a generalizable blueprint for establishing large scale collaborative research consortia
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
- Author
- Abbott TE
- Abdallah RI
- Abdel-Aal IR
- Abdelmonem SA
- Abdo WF
- Abellan AN
- Abellán AN
- Abellán AN
- Abellán AN
- Abrams ST
- Ackerley C
- Acuña M
- Adda M
- Adhikari NK
- Adriano G
- Adrie C
- Affatato R
- Affatato R
- Afonso-Rivero D
- Agarossi A
- Agarwal LK
- Ageeva T
- Agrawal R
- Aguayo-DeHoyos E
- Aguilar AL
- Aguilar-Alonso E
- Aguilar-Alonso E
- Aguilar-Alonso E
- Aguirregabyria M
- Ahmadnia E
- Ahn C
- Ahn JY
- Ahn JY
- Ahn MY
- Ahn MY
- Aitken LM
- Akalaev R
- Akbarzadeh A
- Akcan-Arikan A
- Akhlagh SH
- Akhtar N
- AKI Research Group
- Akiduki N
- Akin S
- Akizuki N
- Akkoc T
- Ala-Kokko T
- Alanio A
- Albaiceta GM
- Albaladejo P
- Alberto F
- Albuisson E
- Alcala MA
- Alcázar L
- Aldabo-Pallas T
- Aldana NN
- Aldecoa C
- Alegría L
- Alejandro R
- Alejo GC
- Alejos RM
- Alexandrova E
- Algarte R
- Algarte R
- Algieri I
- Algora-Weber A
- Alhamdi Y
- Aliaga FA
- Aliberti S
- Alkan A
- Almudena PM
- Almudevar PM
- Almudevar PM
- Almudévar PM
- Altıntas ND
- Alvarez J
- Alves SC
- Alzola LM
- Amargianitakis V
- Amaro R
- Amato MB
- Ambler M
- Amerongen MP
- Amininejad T
- Amor LL
- Amorim V
- Anand RK
- Andersen LW
- Andersson S
- Andoh K
- Andrade AH
- Andrade AH
- Andrade AH
- Andrade G
- Andreis DT
- Andreis DT
- Annane D
- Antonelli M
- Antoniadou A
- Antonio C
- Antonucci E
- Antón DG
- Anzueto A
- Appiani F
- Aquevedo A
- Aragon C
- Araujo NJ
- Araujo VF
- ARIAM registry of adult cardiac surgery
- ARIAM-ANDALUCIA
- Arias CC
- Arias N
- Arias-Verdu MD
- Arias-Verdu MD
- Arias-Verdu MD
- Armaganidis A
- Arora MK
- Arora N
- Arrigo M
- Arslantas MK
- Artiguenave M
- Aslanian P
- Aspide R
- Asyralyyeva G
- Ataman S
- Ataman S
- Atchade E
- Atchade E
- Atchasiri S
- Athapattu P
- Atkins G
- Aublanc M
- Aublanc M
- Augustin P
- Augustin P
- Auquier P
- Avilés-Jurado FX
- Avramidis V
- Ayala LY
- Aydin M
- Azevedo JC
- Azevedo JR
- Aznar GP
- Babalis D
- Babini G
- Bachli EB
- Bader A
- Bader A
- Baena J
- Baidya DK
- Baikova VN
- Bakker J
- Balcázar LC
- Balcázar LC
- Baldassarri R
- Baldwin CE
- Balik M
- Ball I
- Ballin A
- Balsera B
- Banderas-Bravo ME
- Banderas-Bravo ME
- Bandert A
- Bangstad IL
- Baptista N
- Baquero JD
- Barbadillo S
- Barberet G
- Barberet G
- Barberet G
- Barbier J
- Barcenilla F
- Barea-Mendoza JA
- Barinas OD
- Baron AV
- Barrachina LG
- Barral M
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- Bassi GL
- Bates D
- Battistini M
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- Bauer PR
- Baumstarck K
- Baumstarck K
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- Bañeras J
- Beane A
- Beduneau G
- Beduneau G
- Beduneau G
- Beeharry SD
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- Berric A
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- Bhattal MK
- Bhide S
- Bianchi I
- Bianchi I
- Bianzina S
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- Brianti R
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- Bruno K
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- Calvo CP
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- Cameron C
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- CAPCRI Study
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- Carbonara M
- Cardellino S
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- Cariou A
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- Carmona AF
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- Carpio D
- Carratalá A
- Carreira MM
- Carrero-Gómez F
- Carreño ER
- Carreño R
- Carvalho JP
- Carvalho KV
- Casals XN
- Casals XN
- Cassina T
- Castañeda DP
- Castellana D
- Castellanos A
- Castellanos A
- Castillo-Lorente E
- Castillo-Lorente E
- Catalan M
- Catalán RM
- Catena E
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- Cauwenberghs H
- Cavalcanti D
- Cavalheiro AM
- Cavalier E
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- Charron C
- Chatelon J
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- Chaussard M
- Chavanon O
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- Chelly J
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- Chen CM
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- Chen GQ
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- Cheng CC
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- Chernyshuk S
- Chevret S
- Chhor V
- Chiang CC
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- Chiappa C
- Chiou KR
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- Chiu LC
- Chiumello D
- Chiurazzi C
- Chiurazzi C
- Cho Y
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- Choi JY
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- Choi KS
- Choi S
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- Choi YY
- Chok L
- Cholkraisuwat J
- Cholley B
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- Chou W
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- Chouvarda I
- Christopher KB
- Chrétien JM
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- Chumaev A
- Chung CR
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- Cinel I
- Cinnella G
- Citerio G
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- Clemente EA
- Clermont G
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- Cohen Y
- Colaprico A
- Colino L
- Collange O
- Colombo A
- Colombo A
- Colson P
- Combes A
- Concha P
- Connolly B
- Constan A
- Constan A
- Constan A
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- Conti G
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- Cook DJ
- Coombs M
- Cordeiro CP
- Cordero M
- Cordolcini V
- Cordovilla-Guardia S
- Cordón J
- Corona A
- Corona A
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- Corte FD
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- Corzo L
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- Creteur J
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- Curiel-Balsera E
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- Cuthbertson BH
- Cutuli SL
- Câmara M
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- da Silva VZ
- Daga-Ruiz D
- Dalhuisen A
- Dalorzo M
- Damas P
- Dambrosio M
- Damås JK
- Das Neves A
- David H
- Davis C
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- Day A
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- De Backer A
- De Brito-Ashurst I
- De Cassai A
- De Freitas FF
- De Gasperi A
- de Hoyos EA
- De la Calle-Pedrosa N
- de la Fuente MV
- De La Fuente-Martos C
- De La Fuente-Martos C
- De La Rica AS
- De la Torre MA
- De Maglie M
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- De Pascale G
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- De Sanctis F
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- De Sousa I
- de Vera AP
- de Wilde W
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- Deblier I
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- Del Arco A
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- Del Rosario CG
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- Di Gravio V
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- Di Mussi R
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- Elbers PW
- Elgendy M
- Eliet J
- Emmanuel J
- Emmerich M
- Encina B
- Endacott R
- Endacott R
- Engelberts D
- ENVIN-HELICS Study Group
- Erb J
- Erdogan M
- Eroles AA
- Escalada SH
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- Escórcio S
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- Espinasse F
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- Esteban A
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- Fernandez R
- Fernandez-Zamora MD
- Fernández IF
- Fernández L
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- Fernández PA
- Fernández-Barat L
- Fernández-Mondéjar E
- Fernández-Ortega JF
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- Ferri F
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- Ferrón FR
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- Filipe E
- FINNRESUSCI Study Group
- Fischer G
- Fleischmann E
- Fless K
- Floccard B
- Flowers E
- Follin A
- Follin A
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- Fontaiña LP
- Fontana V
- Fontenot T
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- FROG ICU Investigators
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- GETGAG Working Group
- GETGAG/SEMICYUC
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- González-Jiménez AI
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- Hernández A
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- Hernández AA
- Hernández AA
- Hernández AA
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- Hernández-Tejedor A
- Herpain A
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- Hualde JB
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- Hutchings S
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- Hwang GS
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- Ignacio ML
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- Imanaka H
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- Ince C
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- IPREA Study Group
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- Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group
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- Jayasinghe S
- Jean-Baptiste S
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- Jensen JU
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- Jovaisa T
- JSEPTIC (Japanese Society of Education for Physicians and Trainees in Intensive Care) Clinical Trial Group
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- Juanas CA
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- Juliarena A
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- Kolnikova I
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- Kumari BK
- Kumbamu A
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- Kwon WY
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- Kyle UG
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- Lafuente E
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- Lin KC
- Lin KC
- Lin KC
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- Lin KL
- Lin PH
- Lin SC
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- Lischinsky A
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- Liu CP
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- Llorente MÁ
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- Lobo-Civico A
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- Lombardo MD
- Londoño JG
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- Loudet CI
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- Martín-Loeches I
- Martín-Loeches I
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- Martínez M
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- Martínez MV
- Martínez NA
- Martínez-Carmona JF
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- Mejías CR
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- Winder-Rhodes S
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- Yılmaz G
- Yilmazer F
- Yodice P
- Yokoyama M
- Yonis H
- Yonis H
- Yonis H
- Yoon SZ
- Yoruk F
- Yoshida K
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- Yoshida T
- Yoshida T
- Yoshida T
- Yoshihiro S
- Yoshitake E
- You KM
- Youn AM
- Young A
- Yu KM
- Yumoto T
- Yuzawa J
- Yuzawa J
- Zabaletta WJ
- Zabini D
- Zahorec M
- Zaien I
- Zakynthinos S
- Zanello M
- Zani D
- Zarantonello F
- Zayas B
- Zepeda EM
- Zeroual N
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- Zibandah N
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- Zýková I
- Álvarez JT
- Álvarez-Lerma F
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Meeting abstrac
First measurement of the |t|-dependence of coherent J/ψ photonuclear production
- Author
- Acharya S
- Acosta FT
- Adam J
- Adamova D
- Adler A
- Adolfsson J
- Aggarwal MM
- Agnello M
- Agrawal N
- Ahammed Z
- Ahn SU
- Aiola S
- Akindinov A
- Al-Turany M
- Alam SN
- Albuquerque DSD
- Aleksandrov D
- Alessandro B
- Alfanda HM
- Alfaro Molina R
- Ali Y
- Alici A
- Alkin A
- Alme J
- Alt T
- Altenkamper L
- Altsybeev I
- Anaam MN
- Andrei C
- Andreou D
- Andrews HA
- Andronic A
- Angeletti M
- Anguelov V
- Anson C
- Anticic T
- Antinori F
- Antonioli P
- Anwar R
- Apadula N
- Aphecetche L
- Appelshaeuser H
- Arcelli S
- Arnaldi R
- Arratia M
- Arsene IC
- Arslandok M
- Augustinus A
- Averbeck R
- Azmi MD
- Badala A
- Baek YW
- Bagnasco S
- Bailhache R
- Baillie O Villalobos
- Bala R
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- Wilkinson J
- Willems GA
- Williams MCS
- Willsher E
- Windelband B
- Witt WE
- Xu R
- Yalcin S
- Yamakawa K
- Yano S
- Yin Z
- Yokoyama H
- Yoo I-K
- Yoon JH
- Yuan S
- Yurchenko V
- Zaccolo V
- Zaman A
- Zampolli C
- Zanoli HJC
- Zardoshti N
- Zarochentsev A
- Zavada P
- Zaviyalov N
- Zbroszczyk H
- Zhalov M
- Zhang X
- Zhang Y
- Zhang Z
- Zhao C
- Zherebchevskii V
- Zhigareva N
- Zhou D
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- Zhu H
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- Zhu Y
- Zichichi A
- Zimmermann MB
- Zinovjev G
- Zmeskal J
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
The first measurement of the cross section for coherent J/ψ photoproduction as a function of |t|, the square of the momentum transferred between the incoming and outgoing target nucleus, is presented. The data were measured with the ALICE detector in ultra-peripheral Pb–Pb collisions at a centre-of-mass energy per nucleon pair sNN=5.02TeV with the J/ψ produced in the central rapidity region |y|<0.8, which corresponds to the small Bjorken-x range (0.3−1.4)×10−3.
The measured |t|-dependence is not described by computations based only on the Pb nuclear form factor, while the photonuclear cross section is better reproduced by models including shadowing according to the leading-twist approximation, or gluon-saturation effects from the impact-parameter dependent Balitsky–Kovchegov equation. These new results are therefore a valid tool to constrain the relevant model parameters and to investigate the transverse gluonic structure at very low Bjorken-x.publishedVersio
Observation of the diphoton decay of the Higgs boson and measurement of its properties
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abdulsalam A
- Acosta D
- Acosta JG
- Adair A
- Adam W
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adzic P
- Agram J-L
- Ahmad A
- Ahmad M
- Ahuja S
- Akchurin N
- Akgun B
- Akin IV
- Alagoz E
- Albajar C
- Albayrak EA
- Albergo S
- Albrow M
- Alcaraz Maestre J
- Aldaya Martin M
- Alderweireldt S
- Aleksandrov A
- Alexander J
- Alimena J
- Alverson G
- Alves GA
- Amapane N
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- Anagnostou G
- Anastassov A
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Peer reviewe
Multi-ancestry genome-wide association meta-analysis of Parkinson’s disease
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- Aasly JO
- Ahmad-Annuar A
- Akpalu A
- Albin R
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- Alvarez I
- Amod F
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- Anderson TJ
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- Cruchaga C
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- Dadiotis E
- Dagklis I
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- del Rio MJ
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- Springer Nature
- Publication date
- Field of study
\ua9 2023, This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply. Although over 90 independent risk variants have been identified for Parkinson’s disease using genome-wide association studies, most studies have been performed in just one population at a time. Here we performed a large-scale multi-ancestry meta-analysis of Parkinson’s disease with 49,049 cases, 18,785 proxy cases and 2,458,063 controls including individuals of European, East Asian, Latin American and African ancestry. In a meta-analysis, we identified 78 independent genome-wide significant loci, including 12 potentially novel loci (MTF2, PIK3CA, ADD1, SYBU, IRS2, USP8, PIGL, FASN, MYLK2, USP25, EP300 and PPP6R2) and fine-mapped 6 putative causal variants at 6 known PD loci. By combining our results with publicly available eQTL data, we identified 25 putative risk genes in these novel loci whose expression is associated with PD risk. This work lays the groundwork for future efforts aimed at identifying PD loci in non-European populations
Precise determination of the mass of the Higgs boson and tests of compatibility of its couplings with the standard model predictions using proton collisions at 7 and 8 TeV
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- Publication venue
- Publication date
- 01/01/2014
- Field of study
Peer reviewe
Alignment of the ALICE Inner Tracking System with cosmic-ray tracks
- Author
- Aamodt K
- Abel N
- Abeysekara U
- Adamova D
- Aggarwal M
- Agocs AG
- Ahammed Z
- Ahmad A
- Ahmad N
- Ahn SU
- Akimoto R
- Akindinov A
- Aleksandrov D
- Alessandro B
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- Publication venue
- Publication date
- 01/01/2010
- Field of study
37 pages, 15 figures, revised version, accepted by JINSTALICE (A Large Ion Collider Experiment) is the LHC (Large Hadron Collider) experiment devoted to investigating the strongly interacting matter created in nucleus-nucleus collisions at the LHC energies. The ALICE ITS, Inner Tracking System, consists of six cylindrical layers of silicon detectors with three different technologies; in the outward direction: two layers of pixel detectors, two layers each of drift, and strip detectors. The number of parameters to be determined in the spatial alignment of the 2198 sensor modules of the ITS is about 13,000. The target alignment precision is well below 10 micron in some cases (pixels). The sources of alignment information include survey measurements, and the reconstructed tracks from cosmic rays and from proton-proton collisions. The main track-based alignment method uses the Millepede global approach. An iterative local method was developed and used as well. We present the results obtained for the ITS alignment using about 10^5 charged tracks from cosmic rays that have been collected during summer 2008, with the ALICE solenoidal magnet switched off.Peer reviewe
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