41 research outputs found
Structural and Histone Binding Ability Characterizations of Human PWWP Domains
- Author
- A Dhayalan
- A Perrakis
- A Schuetz
- A Vagin
- A Vezzoli
- A Yokoyama
- AA Vagin
- B Sun
- BC Wang
- C Laguri
- C Qiu
- C Wijmenga
- C Xu
- C Xu
- Chao Xu
- CR Bjarkam
- H Li
- H Liu
- HM El-Tahir
- Hong Wu
- Hong Zeng
- I Stec
- I Stec
- IW Davis
- J Eryilmaz
- J Min
- J Min
- J Park
- J Yang
- JF Flanagan
- Jinrong Min
- K Liu
- Ludmila Dombrovski
- M Lepourcelet
- M Okano
- M Vermeulen
- MA Adams-Cioaba
- MA Adams-Cioaba
- Maria F. Amaya
- MC Shun
- MV Botuyan
- P Emsley
- P Zhang
- Petri Kursula
- PR Nielsen
- Robert Lam
- S Maurer-Stroh
- SA Jacobs
- SM Lukasik
- T Chen
- TR Schneider
- W Fischle
- WA Hendrickson
- Wei Qiu
- Wolfram Tempel
- Y Botbol
- Y Guo
- Y Shikauchi
- Y Wang
- Y Watanabe
- Yanming Wang
- YZ Ge
- Z Otwinowski
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2011
- Field of study
The PWWP domain was first identified as a structural motif of 100-130 amino acids in the WHSC1 protein and predicted to be a protein-protein interaction domain. It belongs to the Tudor domain 'Royal Family', which consists of Tudor, chromodomain, MBT and PWWP domains. While Tudor, chromodomain and MBT domains have long been known to bind methylated histones, PWWP was shown to exhibit histone binding ability only until recently.The PWWP domain has been shown to be a DNA binding domain, but sequence analysis and previous structural studies show that the PWWP domain exhibits significant similarity to other 'Royal Family' members, implying that the PWWP domain has the potential to bind histones. In order to further explore the function of the PWWP domain, we used the protein family approach to determine the crystal structures of the PWWP domains from seven different human proteins. Our fluorescence polarization binding studies show that PWWP domains have weak histone binding ability, which is also confirmed by our NMR titration experiments. Furthermore, we determined the crystal structures of the BRPF1 PWWP domain in complex with H3K36me3, and HDGF2 PWWP domain in complex with H3K79me3 and H4K20me3.PWWP proteins constitute a new family of methyl lysine histone binders. The PWWP domain consists of three motifs: a canonical β-barrel core, an insertion motif between the second and third β-strands and a C-terminal α-helix bundle. Both the canonical β-barrel core and the insertion motif are directly involved in histone binding. The PWWP domain has been previously shown to be a DNA binding domain. Therefore, the PWWP domain exhibits dual functions: binding both DNA and methyllysine histones.This article can also be viewed as an enhanced version in which the text of the article is integrated with interactive 3D representations and animated transitions. Please note that a web plugin is required to access this enhanced functionality. Instructions for the installation and use of the web plugin are available in Text S1
Twelve-month observational study of children with cancer in 41 countries during the COVID-19 pandemic
- Author
- Ababneh H
- Abantanga FA
- Abbas AS
- Abdel-Maboud M
- Abdelhafeez H
- Abdelsalam S
- Abdelwahab M
- Abdessamad E
- Abdul-Mumin A
- Abdulai AB
- Abdulkarim A
- Abdulwahed E
- Abib SDV
- Abodest A
- Abou Chaar MK
- Abu Teir SN
- Abualkher K
- Abukhalaf SA
- AbuZa'nouneh F
- Adam E
- Adegboye MO
- Adekanmbi AF
- Ademola-Popoola DS
- Ademuyiwa AO
- Adeyeye AA
- Adhnon A
- Adly M
- Adwi M
- Afolaranmi OJ
- Ahammed MT
- Ahmad Z
- Ahmed A
- Ahmed A
- Ahmed M
- Ajayi EI
- Aji N
- Ajinkpang S
- Akinoso A
- Akinsete AM
- Akova E
- Akter M
- Akter T
- Al Ayed A
- Al Balushi Z
- Al Bolowi N
- Al Bulushi I
- Al Fayez FN
- Al Hamadani O
- Al Shamsi A
- Al Sharqi A
- Al Sharqi J
- Al Shraideh A
- Al Sibai S
- Al-Agele Y
- Al-Basiti A
- Al-Dabaibeh S
- Al-Furais S
- Al-Rawas AAS
- Alakaloko FM
- Alalawi Y
- Alam MA
- Alameer E
- Alamre A
- Albanna AAM
- Alelayan AF
- Alfa Y
- Alhendy M
- Ali AM
- Ali N
- Ali S
- Alias H
- Aliyu T
- Alkhalil MAA
- Allam AR
- Almasri M
- Almihashhish MMF
- AlMirza A
- Almjersah A
- Almowafy RM
- Alnajjar R
- Alrahawy MMA
- AlShabibi AS
- Alshahri M
- Alshamikh MS
- Altaf S
- Ameh EA
- Amira G
- Amirali A
- Ammouze I
- Anwar A
- Ara Z
- Aremu A
- Arshad M
- Asaduzzaman M
- Ashwinee A
- AsifIqbal M
- Atef M
- Au D
- Axiaq A
- Ayasra F
- Aydogmus E
- Ayman A
- Azab MA
- Azeez SA
- Aziz DAA
- Aziz TT
- Azzam A
- Azzam AY
- Baddourah RM
- Badran YS
- Baertschiger RM
- Bahaa A
- Bahaaeldin M
- Bajaj A
- Bamidele OO
- Bandyopadhyay S
- Banu T
- Barola H
- Bascarevic V
- Basher AKMK
- Bassiony M
- Bdurrzzaq A
- Becktell K
- Belkacem B
- Bell N
- Benaouda H
- Benkhial FS
- Bhatti W
- Bhullar KK
- Biala M
- Bimpong KA
- Bode CO
- Boettcher M
- Bogdanovic I
- Bonna M
- Bonsaana GB
- Bouderbala A
- Bouhuwaish A
- Brachini G
- Brar A
- Brown BJ
- Brown R
- Burzeiza EM
- Buyukkapu S
- Bvulani B
- Bwala KJ
- Byrne MHV
- Cakmak G
- Calvagna V
- Carlesse FADC
- Carrolan E
- Casey A
- Chaoui G
- Charuvila S
- Chaubey D
- Chitnis M
- Christison-Lagay E
- Chylinska A
- Cicerchia P
- Cirillo B
- Coelho SD
- Cooper S
- Cozzi D
- Craig BT
- Crespo MD
- Crow K
- Danfodiyo U
- Daniel S
- Dawud B
- de Carvalho LG
- de Carvalho RV
- de Oliveira EP
- de Souza FKM
- Deeb MA
- Der EM
- Dhiman J
- Diz FL
- Do Bom-Sucesso M
- Dobs M
- Dominic C
- Dreimann M
- Drid B
- Drucker M
- Dukundane A
- Dutta R
- Ebada MA
- Effendi I
- Egbuchulem KI
- Ekwunife OH
- El Chazli Y
- El Kassas M
- El Refaee E
- El-Qurneh O
- Elbahnasawy M
- Eldaly U
- Elebute OA
- Elfiky M
- Elhadi M
- Elhaj NOY
- Elhassan MMA
- Elkaoune Y
- Elmandouh O
- Elmandouh R
- Elshenawy A
- Erhabor J
- Erwee D
- Etchill EW
- Fadel S
- Fahmawee T
- Fan JD
- Fanelli MCA
- Faried M
- Fatungase OM
- Fayngor R
- Fehintola AB
- Ferman SE
- Festus K
- Frosch KH
- Fuseini HY
- Galea N
- Gallardo MTP
- Galli-Tsinopoulou A
- Gallo G
- Gandhi S
- Garrigo MM
- Gawrieh B
- Gentle L
- Ghamgh R
- Ghamry MAM
- Ghandour K
- Ghattaura H
- Ghosh D
- Ghozy S
- Goke O
- Gomes P
- Gounni M
- Govind V
- Govindarajan KK
- Grujicic D
- Guillen G
- Gupta M
- Guzlan A
- Hager EI
- Haider F
- Hajar B
- Hamam O
- Hamdan A
- Hamid HKS
- Hamilton E
- Hamizi K
- Han WSP
- Hanafy E
- Harky A
- Harrison I
- Hasanuzzaman M
- Hassanin M
- Hattor KA
- Hatzipantelis E
- Hemlae H
- Hessissen L
- Heuer A
- Hicdonmez T
- Holail MM
- Hraib M
- Humad H
- Hussain SNF
- Ibelli T
- Ibrahim AB
- Ibrahim KOO
- Ibrahim RB
- Idros R
- Ihediwa GC
- Ikechukwu O
- Ikeda A
- Ilic R
- Imran FA
- Irungu EM
- Islam N
- Islam S
- Ismail RMJ
- Jacobsen AS
- Jain R
- Jaisingh DN
- Jasim D
- Jibrin B
- Jindal B
- Johari N
- John B
- John MJ
- Jones T
- KaderAlsaeiti S
- Kadir MY
- Kakkar S
- Kala S
- Kalra G
- Kamboj S
- Kara Y
- Karagiannidis G
- Karim S
- Karplus G
- Karthigeyan M
- Karunanithi G
- Kayal S
- Kebudi R
- Kendirlioglu BC
- Khan M
- Khan M
- Khan MR
- Khan R
- Khayyam N
- Khernane N
- Khoury V
- Kleinman E
- Kloeber JA
- Kopke L
- Kpiniong MJ
- Kumar V
- Kumar V
- Kumari P
- Kunfah SMP
- Kwarteng PG
- Labib A
- Ladipo-Ajayi O
- Laghari FA
- Laila H
- Lakhoo K
- Lal DR
- Lami M
- Lapolla P
- Latiff ZA
- Lau D
- Lawal TA
- Lazic I
- Leon JLG
- Levinson R
- Lim YY
- Lima FFD
- Lo WB
- Lobo F
- Loh AHP
- Loh CK
- Lopez S
- Lorabi S
- Lukong CS
- Luyt J
- Madan R
- Madasu A
- Madhusudanan S
- Mahal H
- Mahalik SK
- Malika M
- Mamdouh K
- Martin B
- Masoud FM
- Masoud HM
- Massoud JG
- Matei AC
- Mathew J
- Matola B
- Mazloum A
- Mbwele B
- McClafferty K
- Mehmood A
- Melamed D
- Meneghini S
- Meyer J
- Michael V
- Mijalcic R
- Milicevic M
- Mingoli A
- Mitul AR
- Mohindra S
- Molino JA
- Monteiro J
- Monteiro JM
- Morshed AKMA
- Mortada AS
- Moses O
- Moujtahid H
- Moussa A
- Mshelbwala PM
- Mughal A
- Muhammad S
- Muma K
- Muma S
- Munezero D
- Murphy M
- Musa KM
- Musa KO
- Musiu P
- Muthukumar A
- Nabi A
- Nadeem A
- Nadeem K
- Nagras S
- Nah SA
- Nahar K
- Najman T
- Nambi G
- Naredi BK
- Nasef RMM
- Nasir AA
- Nastasovic T
- Nath UK
- Nathani P
- Nauhaus H
- Nautiyal H
- Nay S
- Nazari A
- Nesrine A
- Ng YJ
- Ngongola A
- Nguma I
- Nitschke C
- Nri-Ezedi CA
- Nuhu-Koko A
- Nunes S
- Nwatah VE
- Nweze KD
- O'Sullivan BJ
- Obadaini OO
- Obat M
- Ochieng L
- Offiong U
- Ogundele IO
- Ogundoyin OO
- Ogunsua OO
- Ojha BK
- Okunlola AI
- Olalekan AL
- Olaosebikan R
- Olori S
- Olulana ID
- Omokanye KO
- Omran A
- Oni O
- Osuigwe AN
- Owen RL
- Oyesakin AB
- Ozair A
- Ozdemir GN
- Paasche C
- Pachl M
- Padilha MAC
- Pagaduan AL
- Pancharatnam R
- Parwani D
- Patel A
- Patil NR
- Patil P
- Patrick FA
- Paunovic A
- Peter N
- Peters NJ
- Pillarisetti S
- Piplani R
- Portela L
- Priemel M
- Pulock OS
- Qasem AG
- Qatora M
- Qayyum Z
- Qureshi TI
- Ragab S
- Rahim F
- Rahim N
- Rahman LOA
- Rahman SMR
- Rahmoun R
- Rahul SK
- Raj R
- Rajkumar KS
- Rana AN
- Rana MM
- Raza MR
- Reiter A
- Rhee D
- Robinson D
- Roseline NM
- Roth AS
- Royyuru S
- Ruzgar NM
- Saada B
- Saadeldin AM
- Sakar M
- Saleem A
- Saleem R
- Saleh A
- Salehi M
- Sallam I
- Salloum H
- Salman G
- Salunke P
- Samad L
- Sambandan K
- Samir A
- Sapienza P
- Saracoglu A
- Saracoglu KT
- Sayed F
- Sayomi OT
- Scepanovic V
- Schuelke MR
- Sehrawat A
- Seyi-Olajide JO
- Shabani MM
- Shater W
- Shelft M
- Sherief M
- Sherif A
- Sheth M
- Shikha A
- Shinondo P
- Shirke M
- Sholadoye TT
- Shou B
- Siegel A
- Simpson R
- Singh KK
- Singh S
- Singh V
- Smith C
- Smith T
- Solimam ESA
- Souad B
- Sriram S
- Stangenberg M
- Stanimirovic A
- Suleiman DE
- Sultan I
- Suresh V
- Suroy A
- Taha AO
- Tahir A
- Tahir S
- Taibat IT
- Tawel H
- Tawheed A
- Taylor EH
- Tebha SS
- Temiye EO
- Testi AM
- ThankGod NO
- Thompson N
- Togarepi N
- Tolani MA
- Tragiannidis A
- Tripathi M
- Tsotridou E
- Turk K
- Twaha A
- Ukoha K
- Ullrich S
- Umar AM
- Umar AM
- Umeh EO
- Umuroglu T
- Valetopoulou A
- Vasquez JEM
- Velasco P
- Viezens L
- Vojcek A
- Waleed K
- White O
- Wilson S
- Wong JHL
- Wright K
- Yahia G
- Yahya FS
- Yassaad OM
- Yasser A
- Yhoshu E
- Yip SS
- Yousf AME
- Yusof NM
- Zahid S
- Zaman ASK
- Zambon M
- Zani A
- Zarrish J
- Zekkour MA
- Zerizer Y
- Zia N
- Zubaidi SA
- Zuberi H
- Zuberi HK
- Publication venue
- place:BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
- Publication date
- 01/01/2022
- Field of study
Introduction Childhood cancer is a leading cause of death. It is unclear whether the COVID-19 pandemic has impacted childhood cancer mortality. In this study, we aimed to establish all-cause mortality rates for childhood cancers during the COVID-19 pandemic and determine the factors associated with mortality. Methods Prospective cohort study in 109 institutions in 41 countries. Inclusion criteria: children <18 years who were newly diagnosed with or undergoing active treatment for acute lymphoblastic leukaemia, non-Hodgkin's lymphoma, Hodgkin lymphoma, retinoblastoma, Wilms tumour, glioma, osteosarcoma, Ewing sarcoma, rhabdomyosarcoma, medulloblastoma and neuroblastoma. Of 2327 cases, 2118 patients were included in the study. The primary outcome measure was all-cause mortality at 30 days, 90 days and 12 months. Results All-cause mortality was 3.4% (n=71/2084) at 30-day follow-up, 5.7% (n=113/1969) at 90-day follow-up and 13.0% (n=206/1581) at 12-month follow-up. The median time from diagnosis to multidisciplinary team (MDT) plan was longest in low-income countries (7 days, IQR 3-11). Multivariable analysis revealed several factors associated with 12-month mortality, including low-income (OR 6.99 (95% CI 2.49 to 19.68); p<0.001), lower middle income (OR 3.32 (95% CI 1.96 to 5.61); p<0.001) and upper middle income (OR 3.49 (95% CI 2.02 to 6.03); p<0.001) country status and chemotherapy (OR 0.55 (95% CI 0.36 to 0.86); p=0.008) and immunotherapy (OR 0.27 (95% CI 0.08 to 0.91); p=0.035) within 30 days from MDT plan. Multivariable analysis revealed laboratory-confirmed SARS-CoV-2 infection (OR 5.33 (95% CI 1.19 to 23.84); p=0.029) was associated with 30-day mortality. Conclusions Children with cancer are more likely to die within 30 days if infected with SARS-CoV-2. However, timely treatment reduced odds of death. This report provides crucial information to balance the benefits of providing anticancer therapy against the risks of SARS-CoV-2 infection in children with cancer
Parameter induction in continuous univariate distributions: Well-established G families
- Author
- ABD-ELFATTAH AM
- ABD-ELFATTAH AM
- ABD-ELFATTAH AM
- ABDUL-MONIEM IB
- ADEYEMI S
- ADEYEMI S
- Afify WM
- Ahmed N
- AHUJA JC
- AKINSETE A
- AKINSETE A
- AL-HUSSAINI EK
- AL-HUSSAINI EK
- AL-HUSSAINI EK
- AL-HUSSAINI EK
- Al-Hussaini EK and Hussein M
- AL-NASSER AD
- ALEXANDER C
- ALICE T
- ALICE T
- ALICE T
- ALICE T
- ALICE T
- ALJUAID A
- ALSHANGITI AM
- ALSHAWARBEH E
- ALSHAWARBEH E
- ALZAATREH A
- ALZAGHAL A
- AMINI M
- AMUSAN GE
- ARNOLD BC
- ARNOLD BC
- ARYAL GP
- Aryal GP
- ASLAM M
- ATHAR H
- AZZALINI A
- Baharith LA
- BALAKRISHNA N
- BARAKAT HM
- BARRETO-SOUZA W
- BARRETO-SOUZA W
- BARRETO-SOUZA W
- BARRIOS R
- BDAIR OM
- BIDRAM H
- BIDRAM H
- BOURGUIGNION M
- BOURGUIGNION M
- CARDEñO L
- CARONI C
- CARRASCO JMF
- CARRASCO JMF
- CASTELLARS F
- CHAKRABORTY S
- CHAKRABORTY S
- CHO YS
- CHOUDHURY A
- CHRAPEK M
- CIFARELLI DM
- COORAY K
- CORDEIRO GM
- CORDEIRO GM
- CORDEIRO GM
- CORDEIRO GM
- CORDEIRO GM
- CORDEIRO GM
- CORDEIRO GM
- CORDEIRO GM
- CORDEIRO GM
- CORDEIRO GM
- CORDEIRO GM
- CORDEIRO GM
- CORDEIRO GM
- CORDEIRO GM
- CORDEIRO GM
- CORDEIRO GM
- CORDEIRO GM
- CORDEIRO GM
- Cordeiro GM
- CORDEIRO GM
- CORDEIRO GM
- CORDEIRO GM
- CORDEIRO GM
- CORDEIRO GM
- CORDEIRO GM
- CORDEIRO GM
- CORDEIRO GM
- CORDEIRO GM
- CORDEIRO GM
- CORDEIRO GM
- Cordeiro GM and Lemonte AJ
- CORREA MA
- de PASCOA MAR
- DE SANTANA TVF
- DOMMA F
- EL-BASSIOUNY AH
- EL-GOHARY A
- EL-SHERPIENY ESA
- ELBATAL I
- ELBATAL I
- ELBATAL I
- ELBATAL I
- ELJABRI SS
- EUGENE N
- EUGENE N
- FAMOYE F
- FAMOYE F
- FAMOYE F
- FERREIRA JTAS
- FISCHER M
- FLAIH A
- GEORGE D
- GHITANY ME
- GHITANY ME
- GHITANY ME
- GHITANY ME
- GHITANy ME
- GOMES AE
- GOMES AE
- GOMES AE
- GOMPERTZ B
- GOPAL G
- GUI W
- GUI W
- GUI W
- GUPTA AK
- GUPTA AK
- GUPTA RC
- GUPTA RC
- GUPTA RC
- GUPTA RD
- GUPTA RD
- GUPTA RD
- GUPTA RD
- GUPTA RD
- GUPTA RD
- HAMEDANI GH
- HANOOK S
- HASSAN AM
- HIROSE H
- HUSSAIN MA
- JAFARI AA
- JAMJOOM AA
- JAYAKUMAR K
- JAYAKUMAR K
- JIANG R
- JONES MC
- JONES MC
- JONES MC
- JOSE KK
- JOSE KK
- JOSE KK
- JOSE KK
- JOSE KK
- JOSE KK
- JOSE KK
- JOSE KK
- JOSE KK
- KAKADE CS
- KAZEMI MR
- KERSEY JX
- KHAN MZ
- KIM Y
- KONG L
- KONG L
- KOTZ S
- KOZUBOWSKI TJ
- KRISHNA E
- KRISHNA E
- KRISHNA E
- KUMAR D
- KUMAR D
- KUMARASWAMY P
- KUNDU D
- KUNDU D
- LEE C
- LEE C
- LEHMANN EL
- LEMONTE AJ
- LEMONTE AJ
- LEMONTE AJ
- LEÃO J
- LINNIK YV
- LOURENZUTTI R
- MAHMOUD MR
- MAHMOUD MR
- MAHMOUD MR
- MAHMOUDI E
- MAMELI V
- MAMELI V
- MANSOOR M
- MARCIANO FWP
- MARSHALL A
- MARTÍNEZ-FLOREZ G
- MARWA AA
- MASWADAH M
- MAYNARD J
- MAZUCHELI J
- MCDONALD JB
- MCDONALD JB
- MDZINISO NC
- MEROVCI F
- MORAIS AL
- MORAIS AL
- MUDHOLKAR GS
- MUDHOLKAR GS
- MUDHOLKAR GS
- Muhammad H. Tahir
- MUTHULAKSHMI S
- NADARAJAH S
- NADARAJAH S
- NADARAJAH S
- NADARAJAH S
- NADARAJAH S
- NADARAJAH S
- NADARAJAH S
- NADARAJAH S
- NADARAJAH S
- NADARAJAH S
- NADARAJAH S
- NADARAJAH S
- NADARAJAH S
- NADARAJAH S
- NADARAJAH S
- NADARAJAH S
- NADARAJAH S
- NADARAJAH S
- NADARAJAH S
- NADARAJAH S
- NADARAJAH S
- NADARAJAH S
- NADARAJAH S
- NAIK SR
- NANDA AK
- NASSAR MM
- NASSAR MM
- OLUYEDE BO
- PAL M
- PARANAÍBA PF
- PARANAÍBA PF
- PARIKH RV
- PERSSON K
- PESCIM RR
- PESCIM RR
- PILLAI RN
- PILLAI RN
- PILLAI RN
- PUSHKARNA N
- PÉREZ-CASANY M
- QIAN L
- RAJA TA
- RAJASOORIYA S
- RAO GS
- RAO GS
- RAO GS
- RAQAB M
- RAQAB M
- RAQAB M
- RAQAB M
- RISTIĆ MM
- RISTIĆ MM
- RISTIĆ MM
- ROSAIAH K
- RĚGO LC
- SALAH MM
- SALAH MM
- SALEEM AM
- SARABIA JM
- Saralees Nadarajah
- SARHAN AM
- SARHAN AM
- SAULO H
- SHAHbAZ MQ
- SHAKIL M
- SHAMS TM
- SHAW WT
- SHAWKY AI
- SHAWKY AI
- SHAWKY AI
- SHAWKY AI
- SHIRKE DT
- SHIRKE DT
- SHITTU OI
- SILVA GO
- SINGH U
- SINGLA N
- SRIVASTAVA AK
- SUN J
- SURLES JG
- SURLES JG
- SURLES JG
- TAVARES LV
- THOMAS A
- TORABI H
- TORAbI H
- VENKATESAN P
- VERHULST PF
- VERHULST PF
- VERHULST PF
- YANG T
- YEH HC
- ZEA LM
- ZHANG T
- ZOGRAFOS K
- ZOGRAFOS K
- ZOGRAFOS K
- ZUbAIR M
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019
- Author
- Abbafati C
- Abbas KM
- Abbasi M
- Abbasi-Kangevari M
- Abbasifard M
- Abbastabar H
- Abd El Razek HM
- Abd El Razek MM
- Abd-Allah F
- Abdelalim A
- Abdollahi M
- Abdollahpour I
- Abdulkader RS
- Abdullah KH
- Abedi A
- Abedi P
- Abegaz KH
- Abolhassani H
- Abosetugn AE
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- Troeger CE
- Truelsen TC
- Tsai AC
- Tsatsakis A
- Tyrovolas S
- Uddin R
- Ullah I
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- Umeokonkwo CD
- Undurraga EA
- Unnikrishnan B
- Upadhyay E
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- Valdez PR
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- Venketasubramanian N
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- Wickramasinghe ND
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- Wondmeneh TG
- Wondmieneh AB
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- Wu A-M
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- Wunrow HY
- Xie Y
- Xu G
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- Yaminfirooz M
- Yano Y
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- Yeheyis TY
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- Yilgwan CS
- Yilma MT
- Yip P
- Yonemoto N
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- Younis MZ
- Younker TP
- Yousefi B
- Yousefi Z
- Yousefifard M
- Yousefinezhadi T
- Yousuf AY
- Yu C
- Yu Y
- Yuan C-W
- Yuce D
- Yusefzadeh H
- Zadey S
- Zahabi SS
- Zaidi SS
- Zaki L
- Zaki MES
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- Zamani M
- Zamanian M
- Zandian H
- Zangeneh A
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- Zastrozhin MS
- Zewdie KA
- Zhang J
- Zhang Y
- Zhang Z-J
- Zhao JT
- Zhao X-JG
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- Zheleva B
- Zheng P
- Zhou M
- Zhu C
- Ziapour A
- Zimsen SRM
- Zlavog BS
- Zodpey S
- Publication venue
- 'Elsevier BV'
- Publication date
- 17/10/2020
- Field of study
Five insights from the Global Burden of Disease Study 2019
- Author
- Abbafati C
- Abbas KM
- Abbasi M
- Abbasi-Kangevari M
- Abbasifard M
- Abbastabar H
- Abd El Razek HM
- Abd El Razek MM
- Abd-Allah F
- Abdelalim A
- Abdollahi M
- Abdollahpour I
- Abdulkader RS
- Abdullah KH
- Abedi A
- Abedi P
- Abegaz KH
- Abolhassani H
- Abosetugn AE
- Aboyans V
- Abrams EM
- Abreu LG
- Abrigo MRM
- Abu Haimed AK
- Abu-Gharbieh E
- Abu-Raddad LJ
- Abualhasan A
- Abushouk AI
- Acebedo A
- Ackerman IN
- Adabi M
- Adair T
- Adamu AA
- Adebayo OM
- Adedeji IA
- Adekanmbi V
- Adelson JD
- Adeoye AM
- Adetokunboh OO
- Adham D
- Advani SM
- Afarideh M
- Afshari M
- Afshin A
- Agardh EE
- Agarwal G
- Agasthi P
- Agesa KM
- Aghaali M
- Aghamir SMK
- Agrawal A
- Ahmad T
- Ahmadi A
- Ahmadi K
- Ahmadi M
- Ahmadieh H
- Ahmadpour E
- Ahmed MB
- Aji B
- Akalu TY
- Akinyemi RO
- Akinyemiju T
- Akombi B
- Akunna CJ
- Al-Aly Z
- Al-Mekhlafi HM
- Al-Raddadi RM
- Alahdab F
- Alam K
- Alam N
- Alam S
- Alam T
- Alanezi FM
- Alanzi TM
- Albertson SB
- Alcalde-Rabanal JE
- Alema NM
- Alemu BW
- Alemu YM
- Alhabib KF
- Alhassan RK
- Ali M
- Ali S
- Alicandro G
- Alijanzadeh M
- Alinia C
- Alipour V
- Alizade H
- Aljunid SM
- Alla F
- Allebeck P
- Almadi MAH
- Almasi A
- Almasi-Hashiani A
- Almasri NA
- Almulhim AM
- Alonso J
- Altirkawi KA
- Alumran AK
- Alvis-Guzman N
- Alvis-Zakzuk NJ
- Amare AT
- Amare B
- Amini S
- Amini-Rarani M
- Aminorroaya A
- Amiri F
- Amit AML
- Amugsi DA
- Amul GGH
- Anbesu EW
- Ancuceanu R
- Anderlini D
- Anderson JA
- Andrei CL
- Andrei T
- Androudi S
- Angus C
- Anjomshoa M
- Ansari F
- Ansari I
- Ansari-Moghaddam A
- Antonazzo IC
- Antonio CAT
- Antony CM
- Antriyandarti E
- Anvari D
- Anwer R
- Appiah SCY
- Arab-Zozani M
- Arabloo J
- Aravkin AY
- Arba AAK
- Aremu O
- Ariani F
- Aripov T
- Armoon B
- Arnlov J
- Arowosegbe OO
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- Arzani A
- Asaad M
- Asadi-Aliabadi M
- Asadi-Pooya AA
- Asgari S
- Asghari B
- Ashbaugh C
- Assmus M
- Atafar Z
- Athari SS
- Atnafu DD
- Atout MMW
- Atre SR
- Atteraya MS
- Ausloos F
- Ausloos M
- Avila-Burgos L
- Avokpaho EFGA
- Ayano G
- Ayanore MA
- Aynalem GL
- Aynalem YA
- Ayza MA
- Azari S
- Azarian G
- Azene ZN
- Azhar G
- Azzopardi PS
- Babaee E
- Badawi A
- Badiye AD
- Bagherzadeh M
- Bagli E
- Bahrami MA
- Baig AA
- Bairwa M
- Bakhshaei MH
- Bakhtiari A
- Bakkannavar SM
- Balachandran A
- Balakrishnan S
- Balalla S
- Balassyano S
- Baldasseroni A
- Bali AO
- Ball K
- Ballew SH
- Balzi D
- Banach M
- Bandpei MAM
- Banerjee SK
- Banik PC
- Bannick MS
- Bante AB
- Bante SA
- Baraki AG
- Barboza MA
- Barker-Collo SL
- Barnighausen TW
- Barrero LH
- Barthelemy CM
- Barua L
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- Bassat Q
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- Bhutta ZA
- Bibi S
- Bicer BK
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- Bijani A
- Bikbov B
- Bilano V
- Bin Sayeed MS
- Bin Zaman S
- Biondi A
- Birihane BM
- Bisanzio D
- Bisignano C
- Biswas RK
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- Bjorge T
- Bockarie MJ
- Bohlouli S
- Bohluli M
- Bojia HA
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- Brady OJ
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- Brayne C
- Breitborde NJK
- Breitner S
- Brenner H
- Breusov AV
- Briant PS
- Briggs AM
- Briko AN
- Briko NI
- Britton GB
- Brugha T
- Bryazka D
- Buchbinder R
- Bumgarner BR
- Burkart K
- Burnett RT
- Busse R
- Butt ZA
- Caetano dos Santos FL
- Cahill LE
- Cahuana-Hurtado L
- Cai T
- Callender CSKH
- Camera LA
- Campos-Nonato IR
- Cao J
- Car J
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- Carrero JJ
- Carvalho F
- Castaldelli-Maia JM
- Castaneda-Orjuela CA
- Castelpietra G
- Castle CD
- Castro E
- Castro F
- Catala-Lopez F
- Causey K
- Cederroth CR
- Cercy KM
- Cerin E
- Chalek J
- Chandan JS
- Chang AR
- Chang AY
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- Chang K-L
- Charan J
- Charlson FJ
- Chattu VK
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- Cherbuin N
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- Chin KL
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- Cho DY
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- Christensen H
- Chu D-T
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- Chung S-C
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- Cowie BC
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- da Silva DD
- Dahlawi SMA
- Dai H
- Dai H
- Damasceno AAM
- Damiani G
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- Daneshpajouhnejad P
- Dangel WJ
- Danielsson A-K
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- Darshan BB
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- Dean FE
- DeCleene NK
- Deen A
- Defo BK
- Degenhardt L
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- Dellavalle RP
- Demeke FM
- Demoz GT
- Demsie DG
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- Dereje ND
- Deribe K
- Dervenis N
- Desai R
- Desalew A
- Dessie GA
- Deuba K
- Dharmaratne SD
- Dhungana GP
- Dianatinasab M
- Diaz D
- Dichgans M
- Didarloo A
- Dingels ZV
- Dippenaar IN
- Dirac MA
- Djalalinia S
- Do HT
- Dokova K
- Doku DT
- Dolecek C
- Dolgert AJ
- Dorostkar F
- Doshi CP
- Doshi PP
- Doshmangir L
- Douiri A
- Doxey MC
- Doyle KE
- Driscoll TR
- Dubljanin E
- Dunachie SJ
- Duncan BB
- Duraes AR
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- Ebrahimi H
- Edvardsson D
- Effiong A
- Ehrlich JR
- El Nahas N
- El Sayed I
- El Tantawi M
- El-Jaafary SI
- Elbarazi I
- Elgendy IY
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- Elsharkawy A
- Elyazar IRF
- Emamian MH
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- Erskine HE
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- Fanzo J
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- Farahmand M
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- Faridnia R
- Farinha CSES
- Farioli A
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- Faro A
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- Farzadfar F
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- Fazaeli AA
- Fazlzadeh M
- Feigin VL
- Feldman R
- Fereshtehnejad S-M
- Fernandes E
- Ferrara G
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- Ferrari AJ
- Ferreira ML
- Feyissa GT
- Filip I
- Fischer F
- Fisher JL
- Fitzgerald R
- Flohr C
- Flor LS
- Foigt NA
- Folayan MO
- Fomenkov AA
- Force LM
- Fornari C
- Forooshani ZSD
- Foroutan M
- Fox JT
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- Frank TD
- Franklin RC
- Freitas M
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- Fukumoto T
- Fukutaki K
- Fuller JE
- Fullman N
- Furtado JM
- Gad MM
- Gaidhane AM
- Gakidou E
- Galles NC
- Gallus S
- Gamkrelidze A
- Garcia-Basteiro AL
- Gardner WM
- Geberemariyam BS
- Gebrehiwot AM
- Gebremedhin KB
- Gebremeskel GG
- Gebremeskel LG
- Gebresillassie BM
- Gebreslassie AAAA
- Gela JD
- Geramo YCD
- Geremew A
- Gesesew HA
- Gething PW
- Gezae KE
- Ghadimi M
- Ghadiri K
- Ghaffarifar F
- Ghafourifard M
- Ghajar A
- Ghamari F
- Ghashghaee A
- Ghiasvand H
- Ghith N
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- Gilani SA
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- Gopalani SV
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- Guled RA
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- Iqbal U
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- Publication date
- 01/01/2020
- Field of study
The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 provides a rules-based synthesis of the available evidence on levels and trends in health outcomes, a diverse set of risk factors, and health system responses. GBD 2019 covered 204 countries and territories, as well as first administrative level disaggregations for 22 countries, from 1990 to 2019. Because GBD is highly standardised and comprehensive, spanning both fatal and non-fatal outcomes, and uses a mutually exclusive and collectively exhaustive list of hierarchical disease and injury causes, the study provides a powerful basis for detailed and broad insights on global health trends and emerging challenges. GBD 2019 incorporates data from 281 586 sources and provides more than 3.5 billion estimates of health outcome and health system measures of interest for global, national, and subnational policy dialogue. All GBD estimates are publicly available and adhere to the Guidelines on Accurate and Transparent Health Estimate Reporting. From this vast amount of information, five key insights that are important for health, social, and economic development strategies have been distilled. These insights are subject to the many limitations outlined in each of the component GBD capstone papers.Peer reviewe
ICAR: endoscopic skull‐base surgery
- Author
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- Aaron GP
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- American Academy of Pediatrics Steering Committee on Quality Improvement and Management
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- Xie L
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- Yilmazlar S
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- Publication venue
- Publication date
- 01/07/2019
- Field of study
n/
FCC-ee: The Lepton Collider: Future Circular Collider Conceptual Design Report Volume 2
- Author
- Abada A
- Abbrescia M
- AbdusSalam SS
- Abdyukhanov I
- Abramov A
- Aburaia M
- Acar AO
- Adzic PR
- Agaliotis EL
- Agrawal P
- Aguilar-Saavedra JA
- Aguilera-Verdugo JJ
- Aiba M
- Aichinger I
- Aielli G
- Akay A
- Akhundov A
- Aksakal H
- Alaniz EC
- Albacete JL
- Albergo S
- Alekou A
- Aleksa M
- Aleksan R
- Alexahin Y
- Alia RG
- Alioli S
- Allanach BC
- Allport PP
- Altinli M
- Altmannshofer W
- Ambrosio G
- Amorim D
- Amstutz O
- Anderlini L
- Andreazza A
- Andreini M
- Andriatis A
- Andris C
- Andronic A
- Angelucci M
- Antinori F
- Antipov SA
- Antonelli M
- Antonello M
- Antonioli P
- Antusch S
- Anulli F
- Apolinario L
- Apollinari G
- Apollonio A
- Appelo D
- Appleby RB
- Apyan A
- Apyan A
- Arbey A
- Arbuzov A
- Arduini G
- Ari V
- Arias S
- Armesto N
- Arnaldi R
- Arsenyev SA
- Arzeo M
- Asai S
- Aslanides E
- Assmann RW
- Astapovych D
- Atanasov M
- Atieh S
- Attie D
- Auchmann B
- Audurier A
- Aull S
- Aumon S
- Aune S
- Avino F
- Avrillaud G
- Aydin G
- Azatov A
- Azuelos G
- Azzi P
- Azzolini O
- Azzurri P
- Bacchetta N
- Bacchiocchi E
- Bachacou H
- Baek YW
- Baglin V
- Bai Y
- Baird S
- Baker MJ
- Baldwin MJ
- Ball AH
- Ballarino A
- Banerjee S
- Barber DP
- Barducci D
- Barjhoux P
- Barna D
- Barnafoldi GG
- Barnes MJ
- Barr A
- Bartmann W
- Baryshevsky V
- Barzi E
- Bass SA
- Bastianin A
- Baudouy B
- Bauer F
- Bauer M
- Baumgartner T
- Bautista-Guzman I
- Bayindir C
- Beaudette F
- Bedeschi F
- Beguin M
- Behr JK
- Bellafont I
- Bellagamba L
- Bellegarde N
- Belli E
- Bellingeri E
- Bellini F
- Bellomo G
- Belomestnykh S
- Bencivenni G
- Benedikt M
- Bermudez SI
- Bernardi G
- Bernardi J
- Bernet C
- Bernhardt JM
- Bernini C
- Berriaud C
- Bertarelli A
- Bertolucci S
- Besana MI
- Besancon M
- Beznosov O
- Bhat C
- Bhat P
- Biagini ME
- Biarrotte J-L
- Bielert ER
- Biglietti M
- Bilei GM
- Bilki B
- Biscari C
- Bishara F
- Blanco-Garcia OR
- Blanquez FR
- Blekman F
- Blondel A
- Bluemlein J
- Boccali T
- Boels R
- Bogacz SA
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- Publication venue
- SPRINGER HEIDELBERG
- Publication date
- 01/06/2019
- Field of study
In response to the 2013 Update of the European Strategy for Particle Physics, the Future Circular Collider (FCC) study was launched, as an international collaboration hosted by CERN. This study covers a highest-luminosity high-energy lepton collider (FCC-ee) and an energy-frontier hadron collider (FCC-hh), which could, successively, be installed in the same 100 km tunnel. The scientific capabilities of the integrated FCC programme would serve the worldwide community throughout the 21st century. The FCC study also investigates an LHC energy upgrade, using FCC-hh technology. This document constitutes the second volume of the FCC Conceptual Design Report, devoted to the electron-positron collider FCC-ee. After summarizing the physics discovery opportunities, it presents the accelerator design, performance reach, a staged operation scenario, the underlying technologies, civil engineering, technical infrastructure, and an implementation plan. FCC-ee can be built with today’s technology. Most of the FCC-ee infrastructure could be reused for FCC-hh. Combining concepts from past and present lepton colliders and adding a few novel elements, the FCC-ee design promises outstandingly high luminosity. This will make the FCC-ee a unique precision instrument to study the heaviest known particles (Z, W and H bosons and the top quark), offering great direct and indirect sensitivity to new physics
HE-LHC: The High-Energy Large Hadron Collider: Future Circular Collider Conceptual Design Report Volume 4
- Author
- Abada A
- Abbrescia M
- AbdusSalam SS
- Abdyukhanov I
- Abelleira Fernandez J
- Abramov A
- Aburaia M
- Acar AO
- Adzic PR
- Agrawal P
- Aguilar-Saavedra JA
- Aguilera-Verdugo JJ
- Aiba M
- Aichinger I
- Aielli G
- Akay A
- Akhundov A
- Aksakal H
- Albacete JL
- Albergo S
- Alekou A
- Aleksa M
- Aleksan R
- Alemany Fernandez RM
- Alexahin Y
- Alia RG
- Alioli S
- Alipour Tehrani N
- Allanach BC
- Allport PP
- Altinli M
- Altmannshofer W
- Ambrosio G
- Amorim D
- Amstutz O
- Anderlini L
- Andreazza A
- Andreini M
- Andriatis A
- Andris C
- Andronic A
- Angelucci M
- Antinori F
- Antipov SA
- Antonelli M
- Antonello M
- Antonioli P
- Antusch S
- Anulli F
- Apolinario L
- Apollinari G
- Apollonio A
- Appeloe D
- Appleby RB
- Apyan A
- Apyan A
- Arbey A
- Arbuzov A
- Arduini G
- Ari V
- Arias S
- Armesto N
- Arnaldi R
- Arsenyev SA
- Arzeo M
- Asai S
- Aslanides E
- Assmann RW
- Astapovych D
- Atanasov M
- Atieh S
- Attie D
- Auchmann B
- Audurier A
- Aull S
- Aumon S
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- Avino F
- Avrillaud G
- Aydin G
- Azatov A
- Azuelos G
- Azzi P
- Azzolini O
- Azzurri P
- Bacchetta N
- Bacchiocchi E
- Bachacou H
- Baek YW
- Baglin V
- Bai Y
- Baird S
- Baker MJ
- Baldwin MJ
- Ball AH
- Ballarino A
- Banerjee S
- Barber DP
- Barducci D
- Barjhoux P
- Barna D
- Barnafoldi GG
- Barnes MJ
- Barr A
- Barranco Garcia J
- Barreiro Guimaraes da Costa J
- Bartmann W
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- Barzi E
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- Bastianin A
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- Beaudette F
- Bedeschi F
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- Bellingeri E
- Bellini F
- Bellomo G
- Belomestnykh S
- Bencivenni G
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- Slade E
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- Thomas S
- Tiirakari MT
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- Wohlfahrt A
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- Wollmann D
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- Woog D
- Ws Z
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- Wulzer A
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- Yang G
- Yang HJ
- Yao W-M
- Yazgan E
- Yermolchik V
- Yilmaz A
- Yilmaz A
- Yoo H-D
- Yost SA
- You T
- Young C
- Yu F
- Yu T-T
- Zaborowska A
- Zadeh SG
- Zahnd M
- Zanetti M
- Zanotto L
- Zawiejski L
- Zeiler P
- Zerlauth M
- Zernov SM
- Zevi Dell Porta G
- Zhang C
- Zhang H
- Zhang Y
- Zhang Z
- Zhao Z
- Zhong Y-M
- Zhou D
- Zhou J
- Zhuang P
- Zick G
- Zimmermann F
- Zinn-Justin J
- Zivkovic L
- Zlobin AV
- Zobov M
- Zupan J
- Zurita J
- Publication venue
- SPRINGER HEIDELBERG
- Publication date
- 01/07/2019
- Field of study
In response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. The FCC study covered an energy-frontier hadron collider (FCC-hh), a highest-luminosity high-energy lepton collider (FCC-ee), the corresponding 100 km tunnel infrastructure, as well as the physics opportunities of these two colliders, and a high-energy LHC, based on FCC-hh technology. This document constitutes the third volume of the FCC Conceptual Design Report, devoted to the hadron collider FCC-hh. It summarizes the FCC-hh physics discovery opportunities, presents the FCC-hh accelerator design, performance reach, and staged operation plan, discusses the underlying technologies, the civil engineering and technical infrastructure, and also sketches a possible implementation. Combining ingredients from the Large Hadron Collider (LHC), the high-luminosity LHC upgrade and adding novel technologies and approaches, the FCC-hh design aims at significantly extending the energy frontier to 100 TeV. Its unprecedented centre-of-mass collision energy will make the FCC-hh a unique instrument to explore physics beyond the Standard Model, offering great direct sensitivity to new physics and discoveries
FCC-hh: The Hadron Collider: Future Circular Collider Conceptual Design Report Volume 3
- Author
- Abada A
- Abbrescia M
- AbdusSalam SS
- Abdyukhanov I
- Abelleira Fernandez J
- Abramov A
- Aburaia M
- Acar AO
- Adzic PR
- Agrawal P
- Aguilar-Saavedra JA
- Aguilera-Verdugo JJ
- Aiba M
- Aichinger I
- Aielli G
- Akay A
- Akhundov A
- Aksakal H
- Albacete JL
- Albergo S
- Alekou A
- Aleksa M
- Aleksan R
- Alemany Fernandez RM
- Alexahin Y
- Alia RG
- Alioli S
- Alipour Tehrani N
- Allanach BC
- Allport PP
- Altinli M
- Altmannshofer W
- Ambrosio G
- Amorim D
- Amstutz O
- Anderlini L
- Andreazza A
- Andreini M
- Andriatis A
- Andris C
- Andronic A
- Angelucci M
- Antinori F
- Antipov SA
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- Apollonio A
- Appeloe D
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- Ari V
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- Auchmann B
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- Avino F
- Avrillaud G
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- Ball AH
- Ballarino A
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- Bellini F
- Bellomo G
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 18/12/2018
- Field of study
In response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. The FCC study covered an energy-frontier hadron collider (FCC-hh), a highest-luminosity high-energy lepton collider (FCC-ee), the corresponding 100 km tunnel infrastructure, as well as the physics opportunities of these two colliders, and a high-energy LHC, based on FCC-hh technology. This document constitutes the third volume of the FCC Conceptual Design Report, devoted to the hadron collider FCC-hh. It summarizes the FCC-hh physics discovery opportunities, presents the FCC-hh accelerator design, performance reach, and staged operation plan, discusses the underlying technologies, the civil engineering and technical infrastructure, and also sketches a possible implementation. Combining ingredients from the Large Hadron Collider (LHC), the high-luminosity LHC upgrade and adding novel technologies and approaches, the FCC-hh design aims at significantly extending the energy frontier to 100 TeV. Its unprecedented centre of-mass collision energy will make the FCC-hh a unique instrument to explore physics beyond the Standard Model, offering great direct sensitivity to new physics and discoveries
HE-LHC: The High-Energy Large Hadron Collider
- Author
- Abada A
- Abbrescia M
- AbdusSalam SS
- Abdyukhanov I
- Abelleira Fernandez J
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 18/12/2018
- Field of study
In response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. The FCC study covered an energy-frontier hadron collider (FCC-hh), a highest-luminosity high-energy lepton collider (FCC-ee), the corresponding 100 km tunnel infrastructure, as well as the physics opportunities of these two colliders, and a high-energy LHC, based on FCC-hh technology. This document constitutes the third volume of the FCC Conceptual Design Report, devoted to the hadron collider FCC-hh. It summarizes the FCC-hh physics discovery opportunities, presents the FCC-hh accelerator design, performance reach, and staged operation plan, discusses the underlying technologies, the civil engineering and technical infrastructure, and also sketches a possible implementation. Combining ingredients from the Large Hadron Collider (LHC), the high-luminosity LHC upgrade and adding novel technologies and approaches, the FCC-hh design aims at significantly extending the energy frontier to 100 TeV. Its unprecedented centre-of-mass collision energy will make the FCC-hh a unique instrument to explore physics beyond the Standard Model, offering great direct sensitivity to new physics and discoveries