Phase-plane analysis of Friedmann-Robertson-Walker cosmologies in Brans-Dicke gravity

We present an autonomous phase-plane describing the evolution of Friedmann-Robertson-Walker models containing a perfect fluid (with barotropic index gamma) in Brans-Dicke gravity (with Brans-Dicke parameter omega). We find self-similar fixed points corresponding to Nariai's power-law solutions for spatially flat models and curvature-scaling solutions for curved models. At infinite values of the phase-plane variables we recover O'Hanlon and Tupper's vacuum solutions for spatially flat models and the Milne universe for negative spatial curvature. We find conditions for the existence and stability of these critical points and describe the qualitative evolution in all regions of the (omega,gamma) parameter space for 0-3/2. We show that the condition for inflation in Brans-Dicke gravity is always stronger than the general relativistic condition, gamma<2/3.Comment: 24 pages, including 9 figures, LaTe

Nonlinear Dynamics of 3D Massive Gravity

We explore the nonlinear classical dynamics of the three-dimensional theory of "New Massive Gravity" proposed by Bergshoeff, Hohm and Townsend. We find that the theory passes remarkably highly nontrivial consistency checks at the nonlinear level. In particular, we show that: (1) In the decoupling limit of the theory, the interactions of the helicity-0 mode are described by a single cubic term -- the so-called cubic Galileon -- previously found in the context of the DGP model and in certain 4D massive gravities. (2) The conformal mode of the metric coincides with the helicity-0 mode in the decoupling limit. Away from this limit the nonlinear dynamics of the former is described by a certain generalization of Galileon interactions, which like the Galileons themselves have a well-posed Cauchy problem. (3) We give a non-perturbative argument based on the presence of additional symmetries that the full theory does not lead to any extra degrees of freedom, suggesting that a 3D analog of the 4D Boulware-Deser ghost is not present in this theory. Last but not least, we generalize "New Massive Gravity" and construct a class of 3D cubic order massive models that retain the above properties.Comment: 21 page

The histochemistry of thiols and disulphides. II. Methodology of differential staining

The reduction of disulphide bonds by various mercaptans and tri- n -butylphosphine (TBP) has been examined in paraffin sections of rat tissues. A ‘re-reduction’ procedure demonstrating any residual disulphides shows that nearly equivalent endpoints are reached by all of the reagents at pH 8.5 and room temperature, though at greatly differing rates. TBP is the reductant of choice in that it acts rapidly, cannot cause the thiolation which is more or less pronounced with certain mercaptans and least reverses the prior alkylation of native thiol groups by iodoacetate or N-substituted malemides. Supporting studies establish that, except in highly compact structures, native as well as generated thiol groups can be visualized with satisfactory completeness and specificity by N-(4-aminophenyl)maleimide followed by a diazotization and coupling sequence. These findings provide the basis for the selective staining of disulphides, either alone or differentiated from native thiols in the same section.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/42844/1/10735_2005_Article_BF01003139.pd

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe