"The German language and literature special collections at the University library of Frankfurt am Main and the work of the subject specialist" : paper delivered in Göttingen, 4. 9. 2007, at the annual conference of the German Studies Library Group (GSLG)

Contents - BIX: pole position and runner-up - Frankfurt University Library: its responsibilities, its collections, its databases, its supra-regional collecting responsibilities – and some statistics - The "Sondersammelgebiet" Germanistik: its scope and contents, its principal strengths, present situation, and budget - Sammlung Deutscher Drucke: the 1801-1870 segment of the "Distributed National Library" - Information Services: Bibliographie der deutschen Sprach- und Literaturwissenschaft (BDSL), Neuerwerbungsliste Germanistik, Bibliographie germanistischer Bibliographien (BgB), DigiZeitschriften, information bulletins - Work of the Subject Specialist: exhibitions, publicity material"Das Sondersammelgebiet und Fachreferat Germanistik an der Universitätsbibliothek Frankfurt am Main" : Vortrag am 4. 9. 2007 in Göttingen ; Ort: Niedersächsische Staats- und Universitätsbibliothek Göttingen ; Anlass: Annual conference of the German Studies Library Group (GSLG) Inhalt - BIX: Pole position and Runner-up - UB Frankfurt: Funktionen, Zahlen, Sammlungen, Datenbanken, Sondersammelgebiete - SSG Germanistik: Bestand, Schwerpunkte, Gegenwart, Budget, Sammelauftrag - Sammlung Deutscher Drucke: "Verteilte Nationalbibliothek", Zeitsegment 1801-1870 - Informationsdienste: Bibliographie der deutschen Sprach- und Literaturwissenschaft (BDSL), Neuerwerbungsliste Germanistik, Bibliographie germanistischer Bibliographien (BgB), DigiZeitschriften, Flyer - Fachreferat: Literaturausstellungen, Begleithef

Guidelines for the use of flow cytometry and cell sorting in immunological studies

International audienceThe classical model of hematopoiesis established in the mouse postulates that lymphoid cells originate from a founder population of common lymphoid progenitors. Here, using a modeling approach in humanized mice, we showed that human lymphoid development stemmed from distinct populations of CD127(-) and CD127(+) early lymphoid progenitors (ELPs). Combining molecular analyses with in vitro and in vivo functional assays, we demonstrated that CD127(-) and CD127(+) ELPs emerged independently from lympho-mono-dendritic progenitors, responded differently to Notch1 signals, underwent divergent modes of lineage restriction, and displayed both common and specific differentiation potentials. Whereas CD127(-) ELPs comprised precursors of T cells, marginal zone B cells, and natural killer (NK) and innate lymphoid cells (ILCs), CD127(+) ELPs supported production of all NK cell, ILC, and B cell populations but lacked T potential. On the basis of these results, we propose a "two-family" model of human lymphoid development that differs from the prevailing model of hematopoiesis