The metastatic potential of seminomatous germ cell tumours is associated with a specific microRNA pattern

Background Seminomatous germ cell tumours (SGCT) are the most frequent malignancy in young men. Reliable prognostic biomarkers for the prediction of metastasis at diagnosis and the risk of relapse in clinical stage I (CSI) are lacking. Adjuvant therapies carry a risk of overtreatment, whereas salvage therapies have a risk of high toxicities. Thus, the identification of reliable prognostic biomarkers is highly desirable to identify patients who will benefit from early adjuvant treatment. MicroRNAs (miRNAs) regulate tumour development and progression, and their potential as biomarkers has already been proven in a variety of malignancies. Objectives The aim of our study was to define a specific miRNA expression pattern that discriminates metastatic from non‐metastatic primary SGCT. Materials and methods Total RNA was isolated from 24 formalin‐fixed paraffin‐embedded (FFPE) primary SGCT tumours (10 non‐metastatic, five metachronously and nine synchronously metastatic) and from 10 normal testicular tissue samples. Microarray analysis was performed for global miRNA expression profiling. The results were validated by quantitative real‐time polymerase chain reaction (qRT‐PCR). Statistical analysis was performed using SPSS. Results Microarray analyses revealed a specific miRNA pattern that distinguishes metastatic from non‐metastatic SGCT. Sixty‐three miRNAs were differentially expressed in metastatic compared to non‐metastatic tumours (P < .01). Microarray results were confirmed by qRT‐PCR for three out of five selected miRNAs (miR‐29c‐5p, miR‐506‐3p and miR‐371a‐5p; P < .05). All five miRNAs (miR‐29c‐5p, miR‐506‐3p, miR‐1307‐5p, miR‐371a‐5p and miR‐371a‐3p) showed differential expression between tumour and normal tissues (P < .05). Conclusion Metastatic primary SGCTs are characterized by a specific miRNA expression pattern. Therefore, specific miRNAs could represent a new tool to predict the metastatic potential in SGCT patients

Beiträge zur Geschichte des Landkreises Regensburg 6

Das Donautal zwischen Regensburg und Wörth - Beschreibungen und Bilder aus fünf Jahrhunderten; darin: Fendl, Josef: Kaufmannszüge, Treidelpferde und Ordinarischiffe / Zur Verkehrsgeschichte des Regensburger Südostens (S. 3); Arndt, Ernst Moritz: Dem Mäandrischen Strome nach (S. 9); Zur Beruhigung der Reisenden (S. 9); Weber, Carl Julius: Die Nymphen der Donau (S. 9); Bundschue, Johann: So gut wie im Wirtshause (S. 10); Schultes, Joseph August: Herrliche Landschaftsstücke (S. 10); Schultes, Joseph August: Eine sonderbare Erscheinung (S. 10); Schindler, Herbert, Ein Bau aus dem Tagen Barbarossas (S. 11); Schindler, Herbert: Ein Treffpunkt der Romantiker (S. 12); Schindler, Herbert: Dieses lyrische Land (S. 13); Dielhelm, Johann Hermann: Auf einem ziemlich hohen Berg (S. 13); Bepanzert bis zum Scheitel (S. 14); Schultes, Joseph August: Eine der schönsten Punkte (S. 14); Dem Deutschen Ruhme (S. 16); Fürst von Metternich, Clemens: Ein Wald von abgeschnittenen Köpfen (S. 17); Donner, Jos. Alex.: Unheimlich aussehende Donaustaufer (S. 17); Fendl, Josef: Eine verzauberte romantische Landschaft (S. 18); Schultes, Joseph August: In mineralogischer Hinsicht merkwürdig (S. 20); Schultes, Joseph August: Ein Jägersteig am Scheuchen (S. 20); Schultes, Joseph August: Der gefürchtete Baierwein (S. 21); Schultes, Joseph August: Unbedeutende alte Dörfer (S. 22); Ein stattliches Kirchdorf (S. 22); Kaiser Joseph II.: Eine Messe auf dem Donauufer (S. 23); Schindler, Herbert: Wie ein Wachauer Weindorf (S. 23); J.H.: Die Donau bei Wiesent (S. 24); Schultes, Joseph August: Eine Art von Tantalischer Fahrt (S. 24); Der Wein hat viel Schneide (S. 25); Roedig, Michael: Spiegelwellen nach Deutscher Art (S. 25); Roedig, Michael: Etwas von süßer Wehmuth (S. 26); Arndt, Ernst Moritz: Wir landeten im Dorfe Pater (S. 26); Dielhelm, Johann Hermann: Ein feiner Marktflecken (S. 26); Schultes, Joseph August: Ein alter römischer Waffenplatz (S. 28); Berühmt durch die Bayerischen Rüben (S. 28); Fendl, Josef: St. Nikola in Pfatter (S. 28); Schultes, Joseph August: Das schöne, uralte Wörth (S. 29); Eine glückliche Lage (S. 29); Dunzinger, Franz Xaver: Die hehrste der Burgen (S. 30); Schindler, Herbert: Herbes Mittelalter und heitere Renaissance (S. 31); Freyberger, Laurentius: Magie der Donaulandschaft (S. 31); Bauer, Josef Martin: Ein Strom im Strom (S. 33); Britting, Georg: Wie ein silberner Fisch (S. 33

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements

Production of He-4 and (4) in Pb-Pb collisions at root(NN)-N-S=2.76 TeV at the LHC

Results on the production of He-4 and (4) nuclei in Pb-Pb collisions at root(NN)-N-S = 2.76 TeV in the rapidity range vertical bar y vertical bar <1, using the ALICE detector, are presented in this paper. The rapidity densities corresponding to 0-10% central events are found to be dN/dy4(He) = (0.8 +/- 0.4 (stat) +/- 0.3 (syst)) x 10(-6) and dN/dy4 = (1.1 +/- 0.4 (stat) +/- 0.2 (syst)) x 10(-6), respectively. This is in agreement with the statistical thermal model expectation assuming the same chemical freeze-out temperature (T-chem = 156 MeV) as for light hadrons. The measured ratio of (4)/He-4 is 1.4 +/- 0.8 (stat) +/- 0.5 (syst). (C) 2018 Published by Elsevier B.V.Peer reviewe

Azimuthal anisotropy of charged jet production in root s(NN)=2.76 TeV Pb-Pb collisions

We present measurements of the azimuthal dependence of charged jet production in central and semi-central root s(NN) = 2.76 TeV Pb-Pb collisions with respect to the second harmonic event plane, quantified as nu(ch)(2) (jet). Jet finding is performed employing the anti-k(T) algorithm with a resolution parameter R = 0.2 using charged tracks from the ALICE tracking system. The contribution of the azimuthal anisotropy of the underlying event is taken into account event-by-event. The remaining (statistical) region-to-region fluctuations are removed on an ensemble basis by unfolding the jet spectra for different event plane orientations independently. Significant non-zero nu(ch)(2) (jet) is observed in semi-central collisions (30-50% centrality) for 20 <p(T)(ch) (jet) <90 GeV/c. The azimuthal dependence of the charged jet production is similar to the dependence observed for jets comprising both charged and neutral fragments, and compatible with measurements of the nu(2) of single charged particles at high p(T). Good agreement between the data and predictions from JEWEL, an event generator simulating parton shower evolution in the presence of a dense QCD medium, is found in semi-central collisions. (C) 2015 CERN for the benefit of the ALICE Collaboration. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).Peer reviewe

Forward-central two-particle correlations in p-Pb collisions at root s(NN)=5.02 TeV

Two-particle angular correlations between trigger particles in the forward pseudorapidity range (2.5 2GeV/c. (C) 2015 CERN for the benefit of the ALICE Collaboration. Published by Elsevier B. V.Peer reviewe