Evaluating e-portfolio Using by Learning Stages: A Case Study in an Interdisciplinary Program

This study conducts an investigation of posts in the e-portfolio platform of the program: “The interdisciplinary training program for talented college students in science.” Participants in this program were supposed to show their learning portfolios on this platform. Among the 2150 registered students, we randomly selected 126 students who have made at least 3 posts to become the target sample. By identifying the learning stages and posting styles shown by their posts, we find that students are mostly in the surface learning stages and weak in completing their learning portfolios. The results suggest that more strategies should be learned in e-portfolio use. In addition, some related issues about learning performance are also discussed

Non-perturbative structure of the polarized nucleon sea

We investigate the flavour and quark-antiquark structure of the polarized nucleon by calculating the parton distribution functions of the nucleon sea using the meson cloud model. We find that the SU(2) flavor symmetry in the light antiquark sea and quark-antiquark symmetry in the strange quark sea are broken, {\it i.e.} \Delta\ubar < \Delta \dbar and \Delta s < \Delta \sbar. The polarization of the strange sea is found to be positive, which is in contradiction to previous analyses. We predict a much larger quark-antiquark asymmetry in the polarized strange quark sea than that in the unpolarized strange quark sea. Our results for both polarized light quark sea and polarized strange quark sea are consistent with the recent HERMES data.Comment: RevTex, 17 pages plus 8 PS figure

Search for new physics in events with opposite-sign leptons, jets, and missing transverse energy in pp collisions at sqrt(s) = 7 TeV

A search is presented for physics beyond the standard model (BSM) in final states with a pair of opposite-sign isolated leptons accompanied by jets and missing transverse energy. The search uses LHC data recorded at a center-of-mass energy sqrt(s) = 7 TeV with the CMS detector, corresponding to an integrated luminosity of approximately 5 inverse femtobarns. Two complementary search strategies are employed. The first probes models with a specific dilepton production mechanism that leads to a characteristic kinematic edge in the dilepton mass distribution. The second strategy probes models of dilepton production with heavy, colored objects that decay to final states including invisible particles, leading to very large hadronic activity and missing transverse energy. No evidence for an event yield in excess of the standard model expectations is found. Upper limits on the BSM contributions to the signal regions are deduced from the results, which are used to exclude a region of the parameter space of the constrained minimal supersymmetric extension of the standard model. Additional information related to detector efficiencies and response is provided to allow testing specific models of BSM physics not considered in this paper.Comment: Replaced with published version. Added journal reference and DO

Search for Supersymmetry in Di-Photon Final States at sqrt{s} = 1.96 TeV

We report results of a search for supersymmetry (SUSY) with gauge-mediated symmetry breaking in di-photon events collected by the D0 experiment at the Fermilab Tevatron Collider in 2002--2006. In 1.1 fb$^{-1}$ of data, we find no significant excess beyond the background expected from the standard model and set the most stringent lower limits to date for a standard benchmark model on the lightest neutralino and chargino masses of 125 GeV and 229 GeV, respectively, at 95% confidence

Search for squarks and gluinos in events with jets and missing transverse energy using 2.1 fb-1 of ppbar collision data at sqrt(s)=1.96 TeV

A data sample corresponding to an integrated luminosity of 2.1 fb-1 collected by the D0 detector at the Fermilab Tevatron Collider was analyzed to search for squarks and gluinos produced in ppbar collisions at a center-of-mass energy of 1.96 TeV. No evidence for the production of such particles was observed in topologies involving jets and missing transverse energy, and 95% C.L. lower limits of 379 GeV and 308 GeV were set on the squark and gluino masses, respectively, within the framework of minimal supergravity with tan(beta)=3, A0=0, and mu<0. The corresponding previous limits are improved by 54 GeV and 67 GeV

Search for scalar top quarks in the acoplanar charm jets and missing transverse energy final state in ppˉp\bar{p} collisions at s=1.96\sqrt{s}=1.96 TeV

We present a search for the pair production of scalar top quarks, $\tilde{t}$, using 995 pb$^{-1}$ of data collected in $p\bar{p}$ collisions with the D0 detector at the Fermilab Tevatron Collider at $\sqrt{s} = 1.96$ TeV. Both scalar top quarks are assumed to decay into a charm quark and a neutralino ($\tilde{\chi}^{0}_{1}$), where $\tilde{\chi}^{0}_{1}$ is the lightest supersymmetric particle. This leads to a final state with two acoplanar charm jets and missing transverse energy. We find the yield of such events to be consistent with the standard model expectation, and exclude sets of $\tilde{t}$ and $\tilde{\chi}^{0}_{1}$ masses at the 95% C.L. that substantially extend the domain excluded by previous searches.Comment: 10 pages, 5 figures, submitted to Physics Letters

Measurement of the ttbar production cross section and top quark mass extraction using dilepton events in ppbar collisions

We present a measurement of the top quark pair production cross section in ppbar collisions at \sqrt{s}=1.96 TeV using approximately 1 fb^{-1} of data collected with the D0 detector. We consider decay channels containing two high pt charged leptons where one lepton is identified as an electron or a muon while the other lepton can be an electron, a muon or a hadronically decaying tau lepton. For a mass of the top quark of 170 GeV, the measured cross section is 7.5 +1.0-1.0 (stat) +0.7-0.6 (syst) +0.6-0.5 (lumi) pb. Using lepton+tau events only, we measure: \sigma_ttbar \times B(ttbar to ltau bbbar) = 0.13 +0.09-0.08 (stat) +0.06-0.06 (syst) +0.02-0.02 (lumi) pb. Comparing the measured cross section as a function of the mass of the top quark with a partial next-to-next-to leading order Quantum Chromodynamics theoretical prediction, we extract a mass of the top quark of 171.5 +9.9-8.8 GeV, in agreement with direct measurements.Comment: published in Phys. Lett. B, 10 pages, 7 figure

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Large-scale discovery of novel genetic causes of developmental disorders

Despite three decades of successful, predominantly phenotype-driven discovery of the genetic causes of monogenic disorders1, up to half of children with severe developmental disorders of probable genetic origin remain without a genetic diagnosis. Particularly challenging are those disorders rare enough to have eluded recognition as a discrete clinical entity, those with highly variable clinical manifestations, and those that are difficult to distinguish from other, very similar, disorders. Here we demonstrate the power of using an unbiased genotype-driven approach2 to identify subsets of patients with similar disorders. By studying 1,133 children with severe, undiagnosed developmental disorders, and their parents, using a combination of exome sequencing3,4,5,6,7,8,9,10,11 and array-based detection of chromosomal rearrangements, we discovered 12 novel genes associated with developmental disorders. These newly implicated genes increase by 10% (from 28% to 31%) the proportion of children that could be diagnosed. Clustering of missense mutations in six of these newly implicated genes suggests that normal development is being perturbed by an activating or dominant-negative mechanism. Our findings demonstrate the value of adopting a comprehensive strategy, both genome-wide and nationwide, to elucidate the underlying causes of rare genetic disorders

Post-acute COVID-19 neuropsychiatric symptoms are not associated with ongoing nervous system injury

A proportion of patients infected with severe acute respiratory syndrome coronavirus 2 experience a range of neuropsychiatric symptoms months after infection, including cognitive deficits, depression and anxiety. The mechanisms underpinning such symptoms remain elusive. Recent research has demonstrated that nervous system injury can occur during COVID-19. Whether ongoing neural injury in the months after COVID-19 accounts for the ongoing or emergent neuropsychiatric symptoms is unclear. Within a large prospective cohort study of adult survivors who were hospitalized for severe acute respiratory syndrome coronavirus 2 infection, we analysed plasma markers of nervous system injury and astrocytic activation, measured 6 months post-infection: neurofilament light, glial fibrillary acidic protein and total tau protein. We assessed whether these markers were associated with the severity of the acute COVID-19 illness and with post-acute neuropsychiatric symptoms (as measured by the Patient Health Questionnaire for depression, the General Anxiety Disorder assessment for anxiety, the Montreal Cognitive Assessment for objective cognitive deficit and the cognitive items of the Patient Symptom Questionnaire for subjective cognitive deficit) at 6 months and 1 year post-hospital discharge from COVID-19. No robust associations were found between markers of nervous system injury and severity of acute COVID-19 (except for an association of small effect size between duration of admission and neurofilament light) nor with post-acute neuropsychiatric symptoms. These results suggest that ongoing neuropsychiatric symptoms are not due to ongoing neural injury