Diagnostic and interventional radiology: a strategy to introduce reference dose level taking into account the national practice

The purpose of this study is to present a strategy to define the reference dose levels for fluoroscopic, dose-intensive examinations. This work is a part of the project of the Federal Office of Public Health of Switzerland to translate the guidelines of the International Commission on Radiological Protection and the European Union into action. The study will also be used to set reference dose levels on the basis of a national survey. All the fluoroscopic units, involved in the survey, were equipped with a KAP (kerma-area product) meter. All KAP meters were first calibrated to ensure the comparability of the dose measurements. The doses and the dose rates together with subjective image quality measurements were acquired in all the centres. Eight types of examination were chosen by a panel of radiologists, and each of the five centres involved agreed to monitor 20 patients per examination type. A wide variation in the dose and the image quality in fixed geometry was observed. For example, the skin dose rate for abdominal examinations varied in the range of 12-42 mGy min−1 for comparable image quality. Average KAP values of 67, 178, 106, 102, 473, 205, 307 and 316 Gy cm2 were recorded for barium meal, abdominal angiography, cerebral angiography, barium enema, hepatic embolisation, biliary drainage, cerebral embolisation and femoral stenting, respectively. The values obtained in this limited study are generally higher than the ones available in the literature and strategies to optimise these studies have to be discussed. A strict control concerning the denomination of the examination type involved in such a study is mandatory to obtain reliable data. This can only be done through a close collaboration between physicians, radiographers and medical physicist

Casimir scaling of domain wall tensions in the deconfined phase of D=3+1 SU(N) gauge theories

We perform lattice calculations of the spatial 't Hooft k-string tensions in the deconfined phase of SU(N) gauge theories for N=2,3,4,6. These equal (up to a factor of T) the surface tensions of the domain walls between the corresponding (Euclidean) deconfined phases. For T much larger than Tc our results match on to the known perturbative result, which exhibits Casimir Scaling, being proportional to k(N-k). At lower T the coupling becomes stronger and, not surprisingly, our calculations show large deviations from the perturbative T-dependence. Despite this we find that the behaviour proportional to k(N-k) persists very accurately down to temperatures very close to Tc. Thus the Casimir Scaling of the 't Hooft tension appears to be a `universal' feature that is more general than its appearance in the low order high-T perturbative calculation. We observe the `wetting' of these k-walls at T around Tc and the (almost inevitable) `perfect wetting' of the k=N/2 domain wall. Our calculations show that as T tends to Tc the magnitude of the spatial `t Hooft string tension decreases rapidly. This suggests the existence of a (would-be) 't Hooft string condensation transition at some temperature which is close to but below Tc. We speculate on the `dual' relationship between this and the (would-be) confining string condensation at the Hagedorn temperature that is close to but above Tc.Comment: 40 pages, 14 figure

Configurational Entropy and Diffusivity of Supercooled Water

We calculate the configurational entropy S_conf for the SPC/E model of water for state points covering a large region of the (T,rho) plane. We find that (i) the (T,rho) dependence of S_conf correlates with the diffusion constant and (ii) that the line of maxima in S_conf tracks the line of density maxima. Our simulation data indicate that the dynamics are strongly influenced by S_conf even above the mode-coupling temperature T_MCT(rho).Comment: Significant update of reference

Diffusion of gold nanoclusters on graphite

We present a detailed molecular-dynamics study of the diffusion and coalescence of large (249-atom) gold clusters on graphite surfaces. The diffusivity of monoclusters is found to be comparable to that for single adatoms. Likewise, and even more important, cluster dimers are also found to diffuse at a rate which is comparable to that for adatoms and monoclusters. As a consequence, large islands formed by cluster aggregation are also expected to be mobile. Using kinetic Monte Carlo simulations, and assuming a proper scaling law for the dependence on size of the diffusivity of large clusters, we find that islands consisting of as many as 100 monoclusters should exhibit significant mobility. This result has profound implications for the morphology of cluster-assembled materials

Age-Related Attenuation of Dominant Hand Superiority

The decline of motor performance of the human hand-arm system with age is well-documented. While dominant hand performance is superior to that of the non-dominant hand in young individuals, little is known of possible age-related changes in hand dominance. We investigated age-related alterations of hand dominance in 20 to 90 year old subjects. All subjects were unambiguously right-handed according to the Edinburgh Handedness Inventory. In Experiment 1, motor performance for aiming, postural tremor, precision of arm-hand movement, speed of arm-hand movement, and wrist-finger speed tasks were tested. In Experiment 2, accelerometer-sensors were used to obtain objective records of hand use in everyday activities

Prospects for the development of odour baits to control the tsetse flies Glossina tachinoides and G. palpalis s.l.

Field studies were done of the responses of Glossina palpalis palpalis in Côte d'Ivoire, and G. p. gambiensis and G. tachinoides in Burkina Faso, to odours from humans, cattle and pigs. Responses were measured either by baiting (1.) biconical traps or (2.) electrocuting black targets with natural host odours. The catch of G. tachinoides from traps was significantly enhanced (~5×) by odour from cattle but not humans. In contrast, catches from electric targets showed inconsistent results. For G. p. gambiensis both human and cattle odour increased (>2×) the trap catch significantly but not the catch from electric targets. For G. p. palpalis, odours from pigs and humans increased (~5×) the numbers of tsetse attracted to the vicinity of the odour source but had little effect on landing or trap-entry. For G. tachinoides a blend of POCA (P = 3-n-propylphenol; O = 1-octen-3-ol; C = 4-methylphenol; A = acetone) alone or synthetic cattle odour (acetone, 1-octen-3-ol, 4-methylphenol and 3-n-propylphenol with carbon dioxide) consistently caught more tsetse than natural cattle odour. For G. p. gambiensis, POCA consistently increased catches from both traps and targets. For G. p. palpalis, doses of carbon dioxide similar to those produced by a host resulted in similar increases in attraction. Baiting traps with super-normal (~500 mg/h) doses of acetone also consistently produced significant but slight (~1.6×) increases in catches of male flies. The results suggest that odour-baited traps and insecticide-treated targets could assist the AU-Pan African Tsetse and Trypanosomiasis Eradication Campaign (PATTEC) in its current efforts to monitor and control Palpalis group tsetse in West Africa. For all three species, only ~50% of the flies attracted to the vicinity of the trap were actually caught by it, suggesting that better traps might be developed by an analysis of the visual responses and identification of any semiochemicals involved in short-range interaction

Hypothalamic over-expression of VGF in the Siberian hamster increases energy expenditure and reduces body weight gain

VGF (non-acronymic) was first highlighted to have a role in energy homeostasis through experiments involving dietary manipulation in mice. Fasting increased VGF mRNA in the Arc and levels were subsequently reduced upon refeeding. This anabolic role for VGF was supported by observations in a VGF null (VGF-/-) mouse and in the diet-induced and gold-thioglucose obese mice. However, this anabolic role for VGF has not been supported by a number of subsequent studies investigating the physiological effects of VGF-derived peptides. Intracerebroventricular (ICV) infusion of TLQP-21 increased resting energy expenditure and rectal temperature in mice and protected against diet-induced obesity. Similarly, ICV infusion of TLQP-21 into Siberian hamsters significantly reduced body weight, but this was due to a decrease in food intake, with no effect on energy expenditure. Subsequently NERP-2 was shown to increase food intake in rats via the orexin system, suggesting opposing roles for these VGF-derived peptides. Thus to further elucidate the role of hypothalamic VGF in the regulation of energy homeostasis we utilised a recombinant adeno-associated viral vector to over-express VGF in adult male Siberian hamsters, thus avoiding any developmental effects or associated functional compensation. Initially, hypothalamic over-expression of VGF in adult Siberian hamsters produced no effect on metabolic parameters, but by 12 weeks post-infusion hamsters had increased oxygen consumption and a tendency to increased carbon dioxide production; this attenuated body weight gain, reduced interscapular white adipose tissue and resulted in a compensatory increase in food intake. These observed changes in energy expenditure and food intake were associated with an increase in the hypothalamic contents of the VGF-derived peptides AQEE, TLQP and NERP-2. The complex phenotype of the VGF-/- mice is a likely consequence of global ablation of the gene and its derived peptides during development, as well as in the adult