Industrial By-Products As a Novel Circular Source of Biocompatible Extracellular Vesicles

Extracellular vesicles (EVs) constitute an intricate system of molecular exchange that has recently gained tremendous interest. However, sustainable sources of safe biological EVs remain scarce and elusive. This study explores and defines the use of food industry by-products (BP) as a circular source of safe biocompatible EVs. Averaged diameter and molecular compositions indicate a large yield of exosomes and high abundancy of membrane lipids with signaling capacity in these vesicles. Complex proteomes mimicking those circulating in human blood plasma are also identified. Furthermore, BP-EVs do not show relevant cytotoxicity and display excellent oral and intravenous bioavailability together with specific organ targeting capacity. Collectively, it is believed that the novel findings reported here will open substantial venues for the use of BP as an optimal source of biocompatible nanovesicles in manifold applications of the biotechnological and biomedical fields.The authors sincerely thank Gemma Plaza, oenologist at the Castell del Remei winery in Penelles, Lleida, Spain and Juan Carlos Blanco, production manager at Mahou San Miguel in Alovera, Madrid, Spain for their kind and altruistic help on the obtention of their respective industry by-product samples. The authors also thank Dr. Hector Peinado and his research group at the National Center for Oncology Research (CNIO) in Madrid (Spain) for their support on the morphometric characterization of BP-EVs. Support for this work was provided by the Research and Education Council of the Community of Madrid, Spain (2018-T1/ BIO-10633), Ministry of Science and Innovation, Spain (PID2020- 114885RB-C21) and a FIS project by Carlos III Institute of Health (ISCIII), Spain (PI20/00623). A.S. acknowledges a grant from the Talento Program 2018 of the Community of Madrid. X.G.-P. acknowledges grants from Sara Borrell postdoctoral program (CD19/00243) and Miguel Servet tenure track program (CP21/00096) of the Instituto de Salud Carlos III (ISCIII, Spain), respectively awarded on the 2019 and 2021 calls under ISCIII-Health Strategy Actions [These grants are cofunded with European Union Funds (ISCIII Miguel Servet Program 2021 is cofunded by Fondo Social Europeo Plus, FSE+)]. M.V.C. acknowledges a Miguel Servet program contract (CPII20/00007). C.L.’s Ph.D. was funded by the Regional Ministry of Science, Universities and Innovation of the Community of Madrid and the European Social Fund for the recruitment of predoctoral researchers (PEJD-2019-PRE/BIO-16475). IRBLLEIDA and X.G.-P. are co-funded by CERCA Program/Generalitat de Catalunya

EL EMPRENDIMIENTO COMO COMPONENTE DE LA FORMACIÓN DEL ESTUDIANTE UNIVERSITARIO: REALIDAD Y PERSPECTIVAS

El emprendimiento representa una vía muy importante para crecer económicamente al estar vinculado a los aportes que cada sujeto pueda proporcionar a la familia y sociedad. En el artículo se tratan resultados de un estudio acerca del papel que puede desempeñar en la formación  del  estudiante  universitario,  por  lo  que  se  exponen  consideraciones  que  de tenerse en cuenta por las autoridades pertinentes pueden representar una herramienta poderosa en la preparación emprendedora del educando. Para el desarrollo de la actividad investigativa que dio paso a la escritura del presente fueron utilizados métodos y técnicas que permitieron recopilar la información requerida, así como su consecuente análisis. En el trascurso de la investigación se logró precisar vías que garanticen la incorporación del emprendimiento como una asignatura más en la formación académica de los alumnos. Arribándose a conclusiones que develan como llevar el emprendimiento a la vida del escolar, así como sus posibles beneficiarios, partiendo de la inversión que realiza el Estado y los aportes proporcionados por un número significativo de estudiantes

EL EMPRENDIMIENTO COMO COMPONENTE DE LA FORMACIÓN DEL ESTUDIANTE UNIVERSITARIO: REALIDAD Y PERSPECTIVAS

El emprendimiento representa una vía muy importante para crecer económicamente al estar vinculado a los aportes que cada sujeto pueda proporcionar a la familia y sociedad. En el artículo se tratan resultados de un estudio acerca del papel que puede desempeñar en la formación  del  estudiante  universitario,  por  lo  que  se  exponen  consideraciones  que  de tenerse en cuenta por las autoridades pertinentes pueden representar una herramienta poderosa en la preparación emprendedora del educando. Para el desarrollo de la actividad investigativa que dio paso a la escritura del presente fueron utilizados métodos y técnicas que permitieron recopilar la información requerida, así como su consecuente análisis. En el trascurso de la investigación se logró precisar vías que garanticen la incorporación del emprendimiento como una asignatura más en la formación académica de los alumnos. Arribándose a conclusiones que develan como llevar el emprendimiento a la vida del escolar, así como sus posibles beneficiarios, partiendo de la inversión que realiza el Estado y los aportes proporcionados por un número significativo de estudiantes

Physics searches at the LHC

With the LHC up and running, the focus of experimental and theoretical high energy physics will soon turn to an interpretation of LHC data in terms of the physics of electroweak symmetry breaking and the TeV scale. We present here a broad review of models for new TeV-scale physics and their LHC signatures. In addition, we discuss possible new physics signatures and describe how they can be linked to specific models of physics beyond the Standard Model. Finally, we illustrate how the LHC era could culminate in a detailed understanding of the underlying principles of TeV-scale physics.Comment: 184 pages, 55 figures, 14 tables, hundreds of references; scientific feedback is welcome and encouraged. v2: text, references and Overview Table added; feedback still welcom

Comparison of seven prognostic tools to identify low-risk pulmonary embolism in patients aged <50 years

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Association Between Preexisting Versus Newly Identified Atrial Fibrillation and Outcomes of Patients With Acute Pulmonary Embolism

Background Atrial fibrillation (AF) may exist before or occur early in the course of pulmonary embolism (PE). We determined the PE outcomes based on the presence and timing of AF. Methods and Results Using the data from a multicenter PE registry, we identified 3 groups: (1) those with preexisting AF, (2) patients with new AF within 2 days from acute PE (incident AF), and (3) patients without AF. We assessed the 90-day and 1-year risk of mortality and stroke in patients with AF, compared with those without AF (reference group). Among 16 497 patients with PE, 792 had preexisting AF. These patients had increased odds of 90-day all-cause (odds ratio [OR], 2.81; 95% CI, 2.33-3.38) and PE-related mortality (OR, 2.38; 95% CI, 1.37-4.14) and increased 1-year hazard for ischemic stroke (hazard ratio, 5.48; 95% CI, 3.10-9.69) compared with those without AF. After multivariable adjustment, preexisting AF was associated with significantly increased odds of all-cause mortality (OR, 1.91; 95% CI, 1.57-2.32) but not PE-related mortality (OR, 1.50; 95% CI, 0.85-2.66). Among 16 497 patients with PE, 445 developed new incident AF within 2 days of acute PE. Incident AF was associated with increased odds of 90-day all-cause (OR, 2.28; 95% CI, 1.75-2.97) and PE-related (OR, 3.64; 95% CI, 2.01-6.59) mortality but not stroke. Findings were similar in multivariable analyses. Conclusions In patients with acute symptomatic PE, both preexisting AF and incident AF predict adverse clinical outcomes. The type of adverse outcomes may differ depending on the timing of AF onset.info:eu-repo/semantics/publishedVersio

Quines influències té la música quan és en directe en relació quan la mateixa música és enrigstrada a l'aula d'Educació Infantil

Curs 2020-2021El tema d’estudi de la present recerca és veure que la música en directe té més impacte en els infants en comparació a la música enregistrada i la música en format audiovisual. Per això, aquesta recerca fa una anàlisi de com influeix en els infants participar de manera imprevista a una audició musical en directe, i per altra banda, analitzar com influeix en els mateixos infants la música enregistrada per un costat, i la música en vídeo per altre. Així doncs, dels tres formats musicals es vol analitzar les actituds, emocions, reflexions i comentaris espontanis dels tres grups d’infants amb els quals s’ha portat a terme la investigació. El mètode qualitatiu de recollida de dades es fa a través de l’observació directa a l’aula i dels formularis emplenats per les famílies d’on s’extrauran els resultats mitjançant uns indicadors establerts per analitzar la reacció i el comportament individual de cada nen i nena durant l’experiència musical. Les dades interpretades es representen en diagrames de sectors i descripcions complementàries. Referent als resultats, es percep la tendència que les cançons en directe siguin les que causen més impacte als infants.The topic of study of this research is to see that live music has more impact on children compared to canned music and audiovisual format. Therefore, this research analyzes how it influences children to participate in an unexpected way to a live musical hearing, and on the other hand, to analyze how influences in the same children the recording music on the one hand, and video music on the other. Thus, in the three musical formats, we want to analyze the attitudes, emotions, reflections, and spontaneous comments of the three groups of children with whom the research has been carried out. The qualitative method of data collection is done through direct observation in the classroom and the forms filled in by the families from which the results will be drawn using indicators established to analyze the reaction and the individual behavior of each boy and girl during the musical experience. The interpreted data is represented in pie charts and complementary descriptions. In terms of results, there is a tendency for live songs that have the most impact on children

Study of boron behaviour in two spanish coal combustion power plants

A full-scale field study was carried out at two Spanish coal-fired power plants equipped with electrostatic precipitator (ESP) and wet flue gas desulfurisation (FGD) systems to investigate the distribution of boron in coals, solid by-products, wastewater streams and flue gases. The results were obtained from the simultaneous sampling of solid, liquid and gaseous streams and their subsequent analysis in two different laboratories for purposes of comparison. Although the final aim of this study was to evaluate the partitioning of boron in a (co-)combustion power plant, special attention was paid to the analytical procedure for boron determination. A sample preparation procedure was optimised for coal and combustion by-products to overcome some specific shortcomings of the currently used acid digestion methods. In addition boron mass balances and removal efficiencies in ESP and FGD devices were calculated. Mass balance closures between 83 and 149% were obtained. During coal combustion, 95% of the incoming boron was collected in the fly ashes. The use of petroleum coke as co-combustible produced a decrease in the removal efficiency of the ESP (87%). Nevertheless, more than 90% of the remaining gaseous boron was eliminated via the FGD in the wastewater discharged from the scrubber, thereby causing environmental problems.This work was carried out with the aid of a grant from the research fund for coal and steel (RFCR-CT-2006-00006). R.O.G. thanks FICYT (Asturias Regional Research Programme) for funding her PhD work with a fellowship. We would like to thank the staff from the power plants for their support, help and kind assistance before, during and after the sampling campaigns.Peer reviewe

Calcium-activated phospholipid-dependent protein kinase activity in calf platelets.

info:eu-repo/semantics/publishe