Gas phase atomic metals in the circumstellar envelope of IRC+10216

We report the results of a search for gas phase atomic metals in the circumstellar envelope of the AGB carbon star IRC+10216. The search was made using high resolution (R=50000) optical absorption spectroscopy of a backgound star that probes the envelope on a line of sight 35" from the center. The metal species that we detect in the envelope include NaI, KI, CaI, CaII, CrI, and FeI, with upper limits for AlI, MnI, TiI, TiII, and SrII. The observations are used to determine the metal abundances in the gas phase and the condensation onto grains. The metal depletions range from a factor of 5 for Na to 300 for Ca, with some similarity to the depletion pattern in interstellar clouds. Our results directly constrain the condensation efficiency of metals in a carbon-rich circumstellar envelope and the mix of solid and gas phase metals returned by the star to the ISM. The abundances of the uncondensed metal atoms that we observe are typically larger than the abundances of the metal-bearing molecules detected in the envelope. The metal atoms are therefore the major metal species in the gas phase and likely play a key role in the metal chemistry.Comment: 11 pages, 8 Figures. Accepted by Astronomy and Astrophysic

Physical and Biological Release of Poly- and Perfluoroalkyl Substances (PFASs) from Municipal Solid Waste in Anaerobic Model Landfill Reactors

A wide variety of consumer products that are treated with poly- and perfluoroalkyl substances (PFASs) and related formulations are disposed in landfills. Landfill leachate has significant concentrations of PFASs and acts as secondary point sources to surface water. Here, we model how PFASs enter leachate using four lab-scale anaerobic bioreactors filled with municipal solid waste (MSW) and operated over 273 days. Duplicate reactors were monitored under live and abiotic conditions to evaluate influences attributable to biological activity. The biologically-active reactors simulated the methanogenic conditions that develop in all landfills, producing ~140 mL CH₄/dry g refuse. The average total PFAS leaching measured in live reactors (16.7 nmol/kg dry-refuse) was greater than the average for abiotic reactors (2.83 nmol/kg dry-refuse), indicating biological processes were primarily responsible for leaching. The low level leaching in the abiotic reactors was primarily due to PFCAs ≤C8 (2.48 nmol/kg dry-refuse). Concentrations of known biodegradation intermediates, including methylperfluorobutane sulfonamide acetic acid and the n:2 and n:3 fluorotelomer carboxylates, increased steadily in concentration after the onset of methanogenesis, with the 5:3 fluorotelomer carboxylate becoming the single most concentrated PFAS observed in live reactors (9.53 nmol/kg dry-refuse)

Vitamin D, Vitamin A, the primary melanoma transcriptome and survival

Survival from melanoma is influenced by several, well-established clinical and histopathological factors, e.g. age, Breslow thickness and microscopic ulceration. We (the Section of Epidemiology and Biostatistics, University of Leeds) have carried out research to better understand the biological basis for these observations. Preliminary results indicated a protective role for vitamin D in melanoma relapse and that higher vitamin D was associated with thinner primary melanomas. Funding from the British Skin Foundation enabled JNB to establish a study of the effects of vitamin A in melanoma. The results suggested that vitamin A could reduce the protective effect of vitamin D in terms of overall survival. Therefore, we propose that vitamin D3 supplementation alone might be preferable to combined multivitamin preparations, where vitamin D supplementation is deemed to be appropriate. Proving a causal link between vitamin D and melanoma-specific survival is challenging. We have shown limited evidence of causation in a Mendelian randomization experiment (described in more detail later). Recent work in Leeds has also shown that higher vitamin D may be protective for microscopic ulceration. Taken together, vitamin D appears to be associated with less aggressive primary melanomas and may itself influence outcome. We continue to explore the role of vitamin D in melanoma survival and the optimum levels that might be crucial

Investigating the factor structure of the South African Personality Inventory – English version

Abstract: Most psychological measuring instruments developed in Western, educated, industrial, rich, democratic (W.E.I.R.D.) countries have been found to inadequately capture and represent personality outside the borders of these countries. Consequently, culturally informed or indigenous measuring instruments need to be developed. Research purpose: This study aimed to inspect whether an overlap exists between the empirical data obtained and the theoretical six-factor SAPI framework, providing evidence for an indigenous personality structure in a multi-cultural context. Motivation for the study: Psychological professionals in South Africa have been criticised for using culturally biased instruments that do not display an accurate representation of the 11 official cultural groups. The South African Personality Inventory (SAPI) aims to address these criticisms, highlighting the importance of establishing the cultural applicability of the model through model-fit analyses..

ORFEUS echelle spectra: Molecular hydrogen in disk, IVC, and HVC gas in front of the LMC

In front of the LMC molecular hydrogen is found in absorption near 0 km/s, being local disk gas, near +60 km/s in an intermediate velocity cloud, and near +120 km/s, in a high velocity halo cloud. The nature of the gas is discussed based on four ORFEUS far UV spectra of LMC stars and including data from the ground and from the IUE satellite. The local gas is cool and, given a span of sight lines of only 2.5 deg, rather fluffy. The fractional abundance of H_2 varies from log(f)=-5.4 to -3.3. Metal depletions (up to -1.7 dex for Fe) are typical for galactic disk gas. In the IV and HV gas an apparent underabundance of neutral oxygen points to an ionization level of the gas of about 90%. H_2 is detected in IV and HV gas toward HD 269546. In the IV gas we find an H_2 column density of log(N)\simeq15.6. The H_2 excitation indicates that the line of sight samples a cloud at a temperature below 150 K. Column densities are too small to detect the higher UV pumped excitation levels. The high velocity H_2 (log(N)\simeq15.6) is highly excited and probably exposed to a strong radiation field. Its excitation temperature exceeds 1000 K. Due to the radial velocity difference between the halo gas and the Milky Way disk, the unattenuated disk radiation is available for H_2 excitation in the halo. We do not find evidence for an intergalactic origin of this gas; a galactic as well as a Magellanic Cloud origin is possible.Comment: 12 pages, 5 figures, accepted for publication in A&

High-Ion Absorption in Seven GRB Host Galaxies at z=2-4: Evidence for both Circumburst Plasma and Outflowing Interstellar Gas

(Abridged) We use VLT/UVES high-resolution optical spectroscopy of seven GRB afterglows at z_GRB>2 to investigate circumburst and interstellar plasma in the host galaxies. Our sample consists of GRBs 021004, 050730, 050820, 050922C, 060607, 071031, and 080310. Four of these spectra were taken in rapid-response mode, within 30 minutes of the Swift GRB detection. We identify several distinct categories of high-ion absorption at velocities close to z_GRB: (i) Strong high-ion components at z_GRB itself are always seen in OVI, CIV, and SiIV, and usually (in 6 of 7 cases) in NV. We discuss circumburst and interstellar models for the origin of this absorption. Using the non-detection of SIV* toward GRB 050730 together with a UV photo-excitation model, we place a lower limit of 400 pc on the distance of the SIV-bearing gas from the GRB. (ii) Complex, multi-component CIV and SiIV profiles extending over 100-400 km/s around z_GRB are observed in each spectrum; these velocity fields are similar to those measured in damped Lyman-alpha systems at similar redshifts, suggesting a galactic origin. (iii) Asymmetric, blueshifted, absorption-line wings covering 65-140 km/s are seen in the CIV, SiIV, and OVI profiles in 4 of the 7 spectra. The wing kinematics together with the observation that two wings show "Galactic" CIV/SiIV ratios suggest these features trace outflowing ISM gas in the GRB host galaxies. (iv) High-velocity (HV; 500-5000 km/s) components are detected in 6 of the 7 spectra. The HV components show diverse properties. In the cases of GRBs 071031 and 080310, both the ionization level (very high CIV/SiIV ratios and absence of neutral-phase absorption) and the kinematics of the HV components can be explained by Wolf-Rayet winds from the GRB progenitors.Comment: 20 pages, 9 figures (7 in color), accepted by A&A, updated with proof corrections including changes to Table

Driving chronicity in rheumatoid arthritis: perpetuating role of myeloid cells

Acute inflammation is a complex and tightly regulated homeostatic process that includes leukocyte migration from the vasculature into tissues to eliminate the pathogen/injury, followed by a pro-resolving response promoting tissue repair. However, if inflammation is uncontrolled as in chronic diseases such as Rheumatoid Arthritis (RA) it leads to tissue damage and disability. Synovial tissue inflammation in RA patients is maintained by sustained activation of multiple inflammatory positive-feedback regulatory pathways in a variety of cells including myeloid cells. In this review, we will highlight recent evidence uncovering biological mechanisms contributing to the aberrant activation of myeloid cells that contributes to perpetuation of inflammation in RA, and discuss emerging data on anti-inflammatory mediators contributing to sustained remission that may inform a novel category of therapeutic targets

Metal enrichment of the neutral gas of blue compact dwarf galaxies: the compelling case of Pox 36

We present the analysis of the interstellar spectrum of Pox 36 with the Far Ultraviolet Spectroscopic Explorer (FUSE). Pox 36 was selected because of the relatively low foreground gas content that makes it possible to detect absorption-lines weak enough that unseen components should not be saturated. Interstellar lines of HI, NI, OI, SiII, PII, ArI, and FeII are detected. Column densities are derived directly from the observed line profiles except for HI, whose lines are contaminated by stellar absorption. We used the TLUSTY models to remove the stellar continuum and isolate the interstellar component. The best fit indicates that the dominant stellar population is B0. The fit of the interstellar HI line gives a column density of 10^{20.3\pm0.4} cm-2. Chemical abundances were then computed from the column densities using the dominant ionization stage in the neutral gas. Our abundances are compared to those measured from emission-line spectra in the optical. Our results suggest that the neutral gas of Pox 36 is metal-deficient by a factor ~7 as compared to the ionized gas, and they agree with a metallicity of ~1/35 Z$_\odot$. Conclusions: The abundance discontinuity between the neutral and ionized phases implies that most of the metals released by consecutive star-formation episodes mixes with the HI gas. The volume extent of the enrichment is so large that the metallicity of the neutral gas increases only slightly. The star-forming regions could be enriched only by a small fraction (~1%), but it would greatly enhance its metallicity. Our results are compared to those of other BCDs. We confirm the overall underabundance of metals in their neutral gas, with perhaps only the lowest metallicity BCDs showing no discontinuity.Comment: Accepted for publication in A&

The cooking task: making a meal of executive functions

Current standardized neuropsychological tests may fail to accurately capture real-world executive deficits. We developed a computer-based Cooking Task (CT) assessment of executive functions and trialed the measure with a normative group before use with a head-injured population. Forty-six participants completed the computerized CT and subtests from standardized neuropsychological tasks, including the Tower and Sorting Tests of executive function from the Delis-Kaplan Executive Function System (D-KEFS) and the Cambridge prospective memory test (CAMPROMPT), in order to examine whether standardized executive function tasks, predicted performance on measurement indices from the CT. Findings showed that verbal comprehension, rule detection and prospective memory contributed to measures of prospective planning accuracy and strategy implementation of the CT. Results also showed that functions necessary for cooking efficacy differ as an effect of task demands (difficulty levels). Performance on rule detection, strategy implementation and flexible thinking executive function measures contributed to accuracy on the CT. These findings raise questions about the functions captured by present standardized tasks particularly at varying levels of difficulty and during dual-task performance. Our preliminary findings also indicate that CT measures can effectively distinguish between executive function and Full Scale IQ abilities. Results of the present study indicate that the CT shows promise as an ecologically valid measure of executive function for future use with a head-injured population and indexes selective executive function’s captured by standardized tests

Developmental pathways to autism: a review of prospective studies of infants at risk

Autism Spectrum Disorders (ASDs) are neurodevelopmental disorders characterized by impairments in social interaction and communication, and the presence of restrictive and repetitive behaviors. Symptoms of ASD likely emerge from a complex interaction between pre-existing neurodevelopmental vulnerabilities and the child's environment, modified by compensatory skills and protective factors. Prospective studies of infants at high familial risk for ASD (who have an older sibling with a diagnosis) are beginning to characterize these developmental pathways to the emergence of clinical symptoms. Here, we review the range of behavioral and neurocognitive markers for later ASD that have been identified in high-risk infants in the first years of life. We discuss theoretical implications of emerging patterns, and identify key directions for future work, including potential resolutions to several methodological challenges for the field. Mapping how ASD unfolds from birth is critical to our understanding of the developmental mechanisms underlying this disorder. A more nuanced understanding of developmental pathways to ASD will help us not only to identify children who need early intervention, but also to improve the range of interventions available to them