FAB:ulous! Family Literacy Nights: Learning to Listen to Families

This article describes our implementation of a program aimed at supporting families\u27 literacy through books and strategies and through capitalizing on what the families know and care about. We held several Family Literacy Nights in which we planned activities, workshops, and book give-aways around families\u27 interests, discerned during the first event. We struggled with simultaneously accomplishing our goals and those that reflected the families. In this article we share our successes as well as the lessons we learned about how to do this work

TANF/Welfare Client Decline and Community Context in the Rural South, 1997-2000

This article examines the extent to which declines in welfare rolls relate to five major dimensions of community: (1) local demographic composition, (2) local labor market conditions, (3) local civic capacity, (4) local spatial characteristics, and (5) changes in local economic opportunities. Results based on data from the Mississippi Department of Human Services indicate that demographically, economically, and socially advantaged communities were more likely to experience high declines in welfare rolls. Rurality was associated with lower likelihood of high declines in welfare rolls across Mississippi counties. Clearly, a combination of a stronger local economy and social support in a local area increases the likelihood of larger decline in welfare rolls. The analysis presented in this article suggests that there is substantial local variation in the decline in welfare rolls that is associated with local economic and social conditions. The success of welfare reform policies clearly hinge on local conditions. What this analysis cannot reveal is the extent to which decline in welfare rolls is the result of recipients marrying, finding good jobs, or simply running up against time limits imposed by the welfare reform legislation

Amyloid-β accumulation in the CNS in human growth hormone recipients in the UK

Human-to-human transmission of Creutzfeldt–Jakob disease (CJD) has occurred through medical procedures resulting in iatrogenic CJD (iCJD). One of the commonest causes of iCJD was the use of human pituitary-derived growth hormone (hGH) to treat primary or secondary growth hormone deficiency. As part of a comprehensive tissue-based analysis of the largest cohort yet collected (35 cases) of UK hGH-iCJD cases, we describe the clinicopathological phenotype of hGH-iCJD in the UK. In the 33/35 hGH-iCJD cases with sufficient paraffin-embedded tissue for full pathological examination, we report the accumulation of the amyloid beta (Aβ) protein associated with Alzheimer’s disease (AD) in the brains and cerebral blood vessels in 18/33 hGH-iCJD patients and for the first time in 5/12 hGH recipients who died from causes other than CJD. Aβ accumulation was markedly less prevalent in age-matched patients who died from sporadic CJD and variant CJD. These results are consistent with the hypothesis that Aβ, which can accumulate in the pituitary gland, was present in the inoculated hGH preparations and had a seeding effect in the brains of around 50% of all hGH recipients, producing an AD-like neuropathology and cerebral amyloid angiopathy (CAA), regardless of whether CJD neuropathology had occurred. These findings indicate that Aβ seeding can occur independently and in the absence of the abnormal prion protein in the human brain. Our findings provide further evidence for the prion-like seeding properties of Aβ and give insights into the possibility of iatrogenic transmission of AD and CAA

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

Microwave effects in condensed phase chemical systems

EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Preliminary report from the Research Factors Survey 1994

This preliminary report provides an overview of research carried out to date on a URG project; An Identification of Constraints in the Development of Women’s Research as a Means of Developing Strategies to Enhance Research Opportunities. Analysis of the data is continuing. The focus of this report is to identify what staff perceive as existing constraints in developing a research profile at Central Queensland University and to highlight constraints particularly affecting women

Variant Creutzfeldt-Jakob disease: prion protein genotype analysis of positive appendix tissue samples from a retrospective prevalence study

Objective To perform prion protein gene (PRNP) codon 129 analysis in DNA extracted from appendix tissue samples that had tested positive for disease associated prion protein. Design Reanalysis of positive cases identified in a retrospective anonymised unlinked prevalence study of variant Creutzfeldt-Jakob disease (vCJD) in the United Kingdom. Study samples Three positive appendix tissue samples out of 12 674 samples of appendix and tonsil tested for disease associated prion protein. The patients from whom these samples were obtained were aged 20-29 years at the time of surgery, which took place in 1996-9. Setting Pathology departments in two tertiary centres in England and Scotland. Results Adequate DNA was available for analysis in two of the three specimens, both of which were homozygous for valine at codon 129 in the PRNP. Conclusions This is the first indication that the valine homozygous subgroup at codon 129 in the PRNP is susceptible to vCJD infection. All tested clinical cases of vCJD have so far occurred in the methionine homozygous subgroup, and a single case of probable iatrogenic vCJD infection has been identified in one patient who was a methionine/valine heterozygote at this genetic locus. People infected with vCJD with a valine homozygous codon 129 PRNP genotype may have a prolonged incubation period, during which horizontal spread of the infection could occur either from blood donations or from contaminated surgical instruments used on these individuals during the asymptomatic phase of the illness