Maternal scaffolding during play with 12- to 24-month-old infants: stability over time and relations with emerging effortful control

Abstract: There is evidence that parents could influence the development of their children’s effortful control in infancy through social interaction. Playful interactions in infancy often involve scaffolding - i.e. the parental provision of support and modelling for problem solving and learning during play. However, previous research has found little consistency over time in this type of parental scaffolding behaviour with infants. The present study had two aims. The first aim was to use a new, tiered coding system to assess the consistency of maternal scaffolding across toys (at the same time point) and over time. The second aim was to assess whether features of parental scaffolding related to concurrent or future measures of child effortful control. Thirty-six mother-child dyads engaged in joint play when children were 12, 18 and 24 months old. The following inhibitory/effortful control tests were administered: The ‘Grasping Task’, an object-retrieval task using a spoon laden with food at 12 months; Two delay of gratification tasks (Snack Delay and Gift Delay) at 24 months. The Bayley Scales of Infant Development Cognitive Scale was administered at 18 months. Maternal propensity to scaffold was the scaffolding behaviour that showed most consistency across toys and over time. Maternal contingency at 12 months predicted children’s effortful control at 24 months. Sequential analysis indicated that maternal contingent interventions leading to children’s successful actions could be the developmental mechanism underpinning the relationship between contingency and later effortful control. Maternal behaviour during play could lay the foundations for the strategic regulation of cognition and behaviour

Toward a Neuroscientific Understanding of Play: A Dimensional Coding Framework for Analyzing Infant-Adult Play Patterns.

Play during early life is a ubiquitous activity, and an individual's propensity for play is positively related to cognitive development and emotional well-being. Play behavior (which may be solitary or shared with a social partner) is diverse and multi-faceted. A challenge for current research is to converge on a common definition and measurement system for play - whether examined at a behavioral, cognitive or neurological level. Combining these different approaches in a multimodal analysis could yield significant advances in understanding the neurocognitive mechanisms of play, and provide the basis for developing biologically grounded play models. However, there is currently no integrated framework for conducting a multimodal analysis of play that spans brain, cognition and behavior. The proposed coding framework uses grounded and observable behaviors along three dimensions (sensorimotor, cognitive and socio-emotional), to compute inferences about playful behavior in a social context, and related social interactional states. Here, we illustrate the sensitivity and utility of the proposed coding framework using two contrasting dyadic corpora (N = 5) of mother-infant object-oriented interactions during experimental conditions that were either non-conducive (Condition 1) or conducive (Condition 2) to the emergence of playful behavior. We find that the framework accurately identifies the modal form of social interaction as being either non-playful (Condition 1) or playful (Condition 2), and further provides useful insights about differences in the quality of social interaction and temporal synchronicity within the dyad. It is intended that this fine-grained coding of play behavior will be easily assimilated with, and inform, future analysis of neural data that is also collected during adult-infant play. In conclusion, here, we present a novel framework for analyzing the continuous time-evolution of adult-infant play patterns, underpinned by biologically informed state coding along sensorimotor, cognitive and socio-emotional dimensions. We expect that the proposed framework will have wide utility amongst researchers wishing to employ an integrated, multimodal approach to the study of play, and lead toward a greater understanding of the neuroscientific basis of play. It may also yield insights into a new biologically grounded taxonomy of play interactions

Infant-parent emotional synchrony during social and non-social play

There is growing evidence that early experience of play is related to various developmental outcomes, the interchange of positive affect is considered a defining feature of infant-parent play, and may potentially be critical for facilitating early positive development. Despite this, we could find no existing studies comparing the expression of positive affect in different play contexts. The present study explored (1) differences in positive affect expression between social (i.e. joint) and non-social (i.e. separated) play, (2) differences between positive and negative emotion mirroring seen during parent-infant play, and (3) the temporal dynamics of emotional mirroring (parent to infant vs. infant to parent). 20 mother-infant dyads (aged 10.4 month) participated in social and non-social play, whilst their emotional expressions were monitored on video. Our results showed that both mothers and infants showed more positive affect and more affect synchrony during social play than non-social play. Regarding the temporal dynamics of emotional responding, mothers tended to follow, rather than lead, their infants’ positive emotional expressions. Further, mothers responded faster to their infants’ positive emotions during social play as compared to non-social play. By contrast, there were no significant differences on any of these measures for negative emotions. These results indicate that different mechanisms may underpin the exchange of positive and negative affect during parent-infant interactions, and different play contexts result in different levels of positive affect, suggesting social context of play may be a crucial factor in determining play’s developmental benefits

Accessing the Inaccessible: Redefining Play as a Spectrum.

Defining play has plagued researchers and philosophers for years. From describing play as an inaccessible concept due to its complexity, to providing checklists of features, the field has struggled with how to conceptualize and operationalize "play." This theoretical piece reviews the literature about both play and learning and suggests that by viewing play as a spectrum - that ranges from free play (no guidance or support) to guided play and games (including purposeful adult support while maintaining playful elements), we better capture the true essence of play and explain its relationship to learning. Insights from the Science of Learning allow us to better understand why play supports learning across social and academic domains. By changing the lens through which we conceptualize play, we account for previous findings in a cohesive way while also proposing new avenues of exploration for the field to study the role of learning through play across age and context

Accessing the Inaccessible: Redefining Play as a Spectrum

Defining play has plagued researchers and philosophers for years. From describing play as an inaccessible concept due to its complexity, to providing checklists of features, the field has struggled with how to conceptualize and operationalize “play.” This theoretical piece reviews the literature about both play and learning and suggests that by viewing play as a spectrum – that ranges from free play (no guidance or support) to guided play and games (including purposeful adult support while maintaining playful elements), we better capture the true essence of play and explain its relationship to learning. Insights from the Science of Learning allow us to better understand why play supports learning across social and academic domains. By changing the lens through which we conceptualize play, we account for previous findings in a cohesive way while also proposing new avenues of exploration for the field to study the role of learning through play across age and context

Changes in synaptic transmission and protein expression in the brains of adult offspring after prenatal inhibition of the kynurenine pathway

During early brain development, N-methyl-d-aspartate (NMDA) receptors are involved in cell migration, neuritogenesis, axon guidance and synapse formation, but the mechanisms which regulate NMDA receptor density and function remain unclear. The kynurenine pathway of tryptophan metabolism includes an agonist (quinolinic acid) and an antagonist (kynurenic acid) at NMDA receptors and we have previously shown that inhibition of the pathway using the kynurenine-3-monoxygenase inhibitor Ro61-8048 in late gestation produces rapid changes in protein expression in the embryos and effects on synaptic transmission lasting until postnatal day 21 (P21). The present study sought to determine whether any of these effects are maintained into adulthood. After prenatal injections of Ro61-8048 the litter was allowed to develop to P60 when some offspring were euthanized and the brains removed for examination. Analysis of protein expression by Western blotting revealed significantly reduced expression of the GluN2A subunit (32%) and the morphogenetic protein sonic hedgehog (31%), with a 29% increase in the expression of doublecortin, a protein associated with neurogenesis. No changes were seen in mRNA abundance using quantitative real-time polymerase chain reaction. Neuronal excitability was normal in the CA1 region of hippocampal slices but paired-pulse stimulation revealed less inhibition at short interpulse intervals. The amount of long-term potentiation was decreased by 49% in treated pups and recovery after low-frequency stimulation was delayed. The results not only strengthen the view that basal, constitutive kynurenine metabolism is involved in normal brain development, but also show that changes induced prenatally can affect the brains of adult offspring and those changes are quite different from those seen previously at weaning (P21). Those changes may be mediated by altered expression of NMDAR subunits and sonic hedgehog

Environmental effects of ozone depletion, UV radiation and interactions with climate change : UNEP Environmental Effects Assessment Panel, update 2017

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SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues

Variability in SARS-CoV-2 susceptibility and COVID-19 disease severity between individuals is partly due to genetic factors. Here, we identify 4 genomic loci with suggestive associations for SARS-CoV-2 susceptibility and 19 for COVID-19 disease severity. Four of these 23 loci likely have an ethnicity-specific component. Genome-wide association study (GWAS) signals in 11 loci colocalize with expression quantitative trait loci (eQTLs) associated with the expression of 20 genes in 62 tissues/cell types (range: 1:43 tissues/gene), including lung, brain, heart, muscle, and skin as well as the digestive system and immune system. We perform genetic fine mapping to compute 99% credible SNP sets, which identify 10 GWAS loci that have eight or fewer SNPs in the credible set, including three loci with one single likely causal SNP. Our study suggests that the diverse symptoms and disease severity of COVID-19 observed between individuals is associated with variants across the genome, affecting gene expression levels in a wide variety of tissue types

A first update on mapping the human genetic architecture of COVID-19

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