25 research outputs found
Short communication: Broadening the diagnosis panel of reproductive pathogens associated with abortion in ruminants
- Author
- Publication venue
- 'Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria (INIA)'
- Publication date
- 01/01/2018
- Field of study
Diagnosis of abortion in cattle, sheep and goat have been mainly focused on abortive pathogens with a recognized impact in outbreaks, but the aetiologic diagnosis rates have been historically low worldwide. Thus, we analysed the presence of pathogens in abortion outbreaks, focusing on the less-common pathogens in cattle farms with control programmes for reproductive pathogens, and in ovine and caprine farms. Thirty-one cases from Galician farms submitted to our laboratory during 2013-2015 were analysed (16 bovine, 7 ovine and 8 caprine farms) by polymerase chain reaction and culture from foetal tissues (n = 52 foetuses). Diagnosis was reached in 21/31 farms: 9/16 in bovine, 6/7 in ovine and 6/8 in caprine. Campylobacter spp. were found in all three species (3/9 diagnosed cases in bovine, 2/6 in ovine and 4/6 in caprine). Furthermore, Ureaplasma diversum was detected in cattle (4/9 of diagnosed cases), Bovine Viral Diarrhoea Virus – 2 was detected in sheep (2/6) and Neospora caninum in goats (1/6). Our results prove the occurrence of abortion in response to pathogens that are traditionally considered less relevant and rarely included in the diagnosis of ruminant abortion. Therefore, differential diagnosis of abortion should consider these pathogens (at least when other causes have been ruled out), to effectively control abortion in farms
CARB-ES-19 Multicenter Study of Carbapenemase-Producing Klebsiella pneumoniae and Escherichia coli From All Spanish Provinces Reveals Interregional Spread of High-Risk Clones Such as ST307/OXA-48 and ST512/KPC-3
- Author
- Adelina Gimeno
- Alba Belles
- Alba Rivera
- Almudena Tinajas
- Amparo Coira Nieto
- Ana Isabel López-Calleja
- Andrés Canut Blasco
- Antonio Casabella Pernas
- Antonio Oliver
- Antonio Oliver
- Belén Aracil
- Belén Aracil
- Caridad Sainz de Baranda
- Carmen Aldea
- Carmen Aspiroz
- Carmen Liébana
- Carmina Martí Sala
- Carolina Roldán
- Cristina Pitart
- Cristina Seral
- Cristobal del Rosario and Jose Luis Perez Arellano
- Desirèe Gijón
- Desirèe Gijón
- Emilia Cercenado
- Encarnación Clavijo
- Ester Clapés Sanchez
- Eugenio Garduño
- Eva Riquelme Bravo
- Fe Tubau Quintano
- Federico García
- Fernando García Garrote
- Ferran Navarro
- Francisco Javier Ramos
- Fátima Galán Sánchez
- Genoveva Yagüe Guirao
- Germán Bou
- Germán Bou
- Guillermo Ruiz-Carrascoso
- Inmaculada García García
- Irene Gracia-Ahufinger
- Irene Gracia-Ahufinger
- Javier Castillo
- Javier E. Cañada-García
- Javier E. Cañada-García
- Jennifer Villa
- Jesús Oteo-Iglesias
- Jesús Oteo-Iglesias
- Jesús Rodríguez-Baño
- Jordi Vila
- Jordi Vila
- Jorge Calvo
- Jorge Calvo
- Jorge Gaitán
- Jose Luis Barrios Andrés
- Jose Luis Díaz de Tuesta
- José Gutierrez Fernández
- José Leiva and José Luis del Pozo
- José Manuel Azcona
- José María Saavedra
- Juan José González-López
- Juan José González-López
- Juan Manuel Sánchez Hospital de Jérez
- Laura Mora
- Leyre López Soria
- Lidia Garcia Agudo and Soledad Illescas
- Lucía Martínez Lamas
- Luis López-Urrutia Lorente
- Luis Martínez-Martínez
- Luis Martínez-Martínez
- Luis Martínez-Martínez
- Luis Torres Sopena
- M. Pilar Ortega Lafont
- M.a José Rodríguez Escudero
- Ma Dolores Quesada
- Ma Isabel Cabeza
- Ma Isabel Fernández Natal and Marta Arias
- Ma Isabel Paz Vidal
- Ma Luisa Pérez del Molino Bernal
- Ma Luz Albina Cordón Rodriguez
- Ma Teresa Cabezas Fernández
- Mar Olga Pérez Moreno
- Maria Pilar Chocarro
- Mariela Martínez Ramírez
- Marta Lamata Subero
- María E. Cano
- María Gomáriz Díaz
- María Huertas
- María Lecuona
- María Pérez-Vázquez
- María Pérez-Vázquez
- Matxalen Vidal-García
- Mercedes Delgado-Valverde
- Mercedes Delgado-Valverde
- Mercè García González
- Miriam Albert Hernández
- Miriam Valverde Troya and Begoña Palop
- Moises García Bravo
- Mónica González
- Mónica González
- Natalia Chueca
- Nerea Sanchez
- Nieves Gonzalo Jiménez
- Nieves Larrosa
- Nieves Larrosa
- Nuria Iglesias Nuñez
- Nuria Prim
- Oscar Esparcia Rodríguez
- Pedro de la Iglesia
- Pedro J. Sola-Campoy
- Pilar Zamarrón
- Rafael Cantón
- Rafael Cantón
- Rafael Sánchez Arroyo
- Raquel Elisa Rodríguez Tarazona
- Rosario Sánchez Benito
- Salvador Giner and Juan Frasquet
- Sonia Rey Cao
- Susana Hernando
- Susana Sabater
- the GEMARA/GEIRAS-SEIMC/REIPI CARB-ES-19 Study Group
- Xavier Mulet
- Xavier Mulet
- Zaira Moure
- Zaira R. Palacios-Baena
- Zaira R. Palacios-Baena
- Zaira R. Palacios-Baena
- Álvaro Pascual
- Álvaro Pascual
- Álvaro Pascual
- Publication venue
- Frontiers Media S.A.
- Publication date
- 01/06/2022
- Field of study
ObjectivesCARB-ES-19 is a comprehensive, multicenter, nationwide study integrating whole-genome sequencing (WGS) in the surveillance of carbapenemase-producing K. pneumoniae (CP-Kpn) and E. coli (CP-Eco) to determine their incidence, geographical distribution, phylogeny, and resistance mechanisms in Spain.MethodsIn total, 71 hospitals, representing all 50 Spanish provinces, collected the first 10 isolates per hospital (February to May 2019); CPE isolates were first identified according to EUCAST (meropenem MIC > 0.12 mg/L with immunochromatography, colorimetric tests, carbapenem inactivation, or carbapenem hydrolysis with MALDI-TOF). Prevalence and incidence were calculated according to population denominators. Antibiotic susceptibility testing was performed using the microdilution method (EUCAST). All 403 isolates collected were sequenced for high-resolution single-nucleotide polymorphism (SNP) typing, core genome multilocus sequence typing (cgMLST), and resistome analysis.ResultsIn total, 377 (93.5%) CP-Kpn and 26 (6.5%) CP-Eco isolates were collected from 62 (87.3%) hospitals in 46 (92%) provinces. CP-Kpn was more prevalent in the blood (5.8%, 50/853) than in the urine (1.4%, 201/14,464). The cumulative incidence for both CP-Kpn and CP-Eco was 0.05 per 100 admitted patients. The main carbapenemase genes identified in CP-Kpn were blaOXA–48 (263/377), blaKPC–3 (62/377), blaVIM–1 (28/377), and blaNDM–1 (12/377). All isolates were susceptible to at least two antibiotics. Interregional dissemination of eight high-risk CP-Kpn clones was detected, mainly ST307/OXA-48 (16.4%), ST11/OXA-48 (16.4%), and ST512-ST258/KPC (13.8%). ST512/KPC and ST15/OXA-48 were the most frequent bacteremia-causative clones. The average number of acquired resistance genes was higher in CP-Kpn (7.9) than in CP-Eco (5.5).ConclusionThis study serves as a first step toward WGS integration in the surveillance of carbapenemase-producing Enterobacterales in Spain. We detected important epidemiological changes, including increased CP-Kpn and CP-Eco prevalence and incidence compared to previous studies, wide interregional dissemination, and increased dissemination of high-risk clones, such as ST307/OXA-48 and ST512/KPC-3
Observation of gravitational waves from the coalescence of a 2.5–4.5 M ⊙ compact object and a neutron star
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- Abac A. G.
- Abbott R.
- Abchouyeh M. Aghaei
- Abouelfettouh I.
- Acernese F.
- Ackley K.
- Adhicary S.
- Adhikari N.
- Adhikari R. X.
- Adkins V. K.
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- Aguilar I.
- Aiello L.
- Ain A.
- Ajith P.
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- Al-Jodah A.
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- Albanesi S.
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- Woehler J.
- Wofford J. K.
- Wolfe N. E.
- Wong H. T.
- Wong H. W. Y.
- Wong I. C. F.
- Wright J. L.
- Wright M.
- Wu C.
- Wu D. S.
- Wu H.
- Wuchner E.
- Wysocki D. M.
- Xu V. A.
- Xu Y.
- Yaala M. Ben
- Yadav N.
- Yamamoto H.
- Yamamoto K.
- Yamamoto T.
- Yamamoto T. S.
- Yamamura S.
- Yamazaki R.
- Yan S.
- Yan T.
- Yang F.
- Yang F. W.
- Yang K. Z.
- Yang Y.
- Yarbrough Z.
- Yasui H.
- Yeh S.-W.
- Yelikar A. B.
- Yin X.
- Yokoyama J.
- Yokozawa T.
- Yoo J.
- Yu H.
- Yuan S.
- Yuzurihara H.
- Zadrożny A.
- Zanolin M.
- Zeeshan M.
- Zelenova T.
- Zendri J.-P.
- Zeoli M.
- Zerrad M.
- Zevin M.
- Zhang A. C.
- Zhang L.
- Zhang R.
- Zhang T.
- Zhang Y.
- Zhao C.
- Zhao Yue
- Zhao Yuhang
- Zheng Y.
- Zhong H.
- Zhou R.
- Zhu X.-J.
- Zhu Z.-H.
- Zimmerman A. B.
- Zucker M. E.
- Zweizig J.
- Publication venue
- American Astronomical Society
- Publication date
- 26/07/2024
- Field of study
We report the observation of a coalescing compact binary with component masses 2.5–4.5 M ⊙ and 1.2–2.0 M ⊙ (all measurements quoted at the 90% credible level). The gravitational-wave signal GW230529_181500 was observed during the fourth observing run of the LIGO–Virgo–KAGRA detector network on 2023 May 29 by the LIGO Livingston observatory. The primary component of the source has a mass less than 5 M ⊙ at 99% credibility. We cannot definitively determine from gravitational-wave data alone whether either component of the source is a neutron star or a black hole. However, given existing estimates of the maximum neutron star mass, we find the most probable interpretation of the source to be the coalescence of a neutron star with a black hole that has a mass between the most massive neutron stars and the least massive black holes observed in the Galaxy. We provisionally estimate a merger rate density of 55−47+127Gpc−3yr−1 for compact binary coalescences with properties similar to the source of GW230529_181500; assuming that the source is a neutron star–black hole merger, GW230529_181500-like sources may make up the majority of neutron star–black hole coalescences. The discovery of this system implies an increase in the expected rate of neutron star–black hole mergers with electromagnetic counterparts and provides further evidence for compact objects existing within the purported lower mass gap
The ALICE experiment at the CERN LHC
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- Achenbach R.
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- Šafařík K.
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- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2008
- Field of study
ALICE (A Large Ion Collider Experiment) is a general-purpose, heavy-ion detector at the CERN LHC which focuses on QCD, the strong-interaction sector of the Standard Model. It is designed to address the physics of strongly interacting matter and the quark-gluon plasma at extreme values of energy density and temperature in nucleus-nucleus collisions. Besides running with Pb ions, the physics programme includes collisions with lighter ions, lower energy running and dedicated proton-nucleus runs. ALICE will also take data with proton beams at the top LHC energy to collect reference data for the heavy-ion programme and to address several QCD topics for which ALICE is complementary to the other LHC detectors. The ALICE detector has been built by a collaboration including currently over 1000 physicists and engineers from 105 Institutes in 30 countries. Its overall dimensions are 161626 m3 with a total weight of approximately 10 000 t. The experiment consists of 18 different detector systems each with its own specific technology choice and design constraints, driven both by the physics requirements and the experimental conditions expected at LHC. The most stringent design constraint is to cope with the extreme particle multiplicity anticipated in central Pb-Pb collisions. The different subsystems were optimized to provide high-momentum resolution as well as excellent Particle Identification (PID) over a broad range in momentum, up to the highest multiplicities predicted for LHC. This will allow for comprehensive studies of hadrons, electrons, muons, and photons produced in the collision of heavy nuclei. Most detector systems are scheduled to be installed and ready for data taking by mid-2008 when the LHC is scheduled to start operation, with the exception of parts of the Photon Spectrometer (PHOS), Transition Radiation Detector (TRD) and Electro Magnetic Calorimeter (EMCal). These detectors will be completed for the high-luminosity ion run expected in 2010. This paper describes in detail the detector components as installed for the first data taking in the summer of 2008
Effect of Neonatal Asphyxia on the Impairment of the Auditory Pathway by Recording Auditory Brainstem Responses in Newborn Piglets: A New Experimentation Model to Study the Perinatal Hypoxic-Ischemic Damage on the Auditory System
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- A Alvarez-Díaz
- Agustin Martinez-Ibargüen
- AJ du Plessis
- AL Smit
- Ana Sanchez-del-Rey
- Antonia Alvarez
- AU Kishan
- C Meyer
- C Peeters-Scholte
- D Alonso-Alconada
- D Alonso-Alconada
- Daniel Alonso-Alconada
- E Hilario
- Enrique Hilario
- EW Rubel
- F Cao
- F Goñi-de-Cerio
- FJ Alvarez
- Francisco Jose Alvarez
- Francisco Santaolalla
- H Lafuente
- Hector Lafuente
- Ibargüen A Martínez
- JJ Volpe
- JM Appler
- JM Perlman
- KA Foster
- KJ Todd
- Lucio Annunziato
- M Soehle
- M Zaaroor
- M Zaaroor
- Miren Revuelta
- Olatz Arteaga
- PP Lefebvre
- S Schubert
- SM Echteler
- TE Inder
- V Newton
- ZD Jiang
- ZD Jiang
- ZD Jiang
- ZD Jiang
- ZD Jiang
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
First Targeted Search for Gravitational-Wave Bursts from Core-Collapse Supernovae in Data of First-Generation Laser Interferometer Detectors
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- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2016
- Field of study
International audienceWe present results from a search for gravitational-wave bursts coincident with a set of two core-collapse supernovae observed between 2007 and 2011. We employ data from the Laser Interferometer Gravitational-wave Observatory (LIGO), the Virgo gravitational-wave observatory, and the GEO 600 gravitational-wave observatory. The targeted core-collapse supernovae were selected on the basis of (1) proximity (within approximately 15 Mpc), (2) tightness of observational constraints on the time of core collapse that defines the gravitational-wave search window, and (3) coincident operation of at least two interferometers at the time of core collapse. We find no plausible gravitational-wave candidates. We present the probability of detecting signals from both astrophysically well-motivated and more speculative gravitational-wave emission mechanisms as a function of distance from Earth, and discuss the implications for the detection of gravitational waves from core-collapse supernovae by the upgraded Advanced LIGO and Virgo detectors
Delaying surgery for patients with a previous SARS-CoV-2 infection
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- A A Ali Karar
- A A Kerawala
- A A Marra
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- U Fumagalli Romario
- U G Vo
- U Grossi
- U Jayarajah
- U M Jariod Ferrer
- U Ribeiro Junior
- U Ronellenfitsch
- U Selbong
- U Speth
- V Alexoudi
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- V D Mandato
- V De Simone
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- Á De la Hoz Rodríguez
- Á Fernández Camuñas
- É Ryan
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- А Камалов
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2020
- Field of study
Not availabl
Association between convalescent plasma treatment and mortality in COVID-19: a collaborative systematic review and meta-analysis of randomized clinical trials
- Author
- Aalborg University
- Aalborg University Hospital
- Abayomi Akin
- Abduljalil Manal
- Abdulrahman Abdulkarim
- Acosta-Ampudia Yeny
- Aguilar-Guisado Manuela
- Ahvaz Jundishapur University of Medical Sciences
- Al-Beidh Farah
- Alejandria Marissa M.
- Alfonso Rachelle N.
- Ali Mohammad
- AlQahtani Manaf
- AlZamrooni Alaa
- Anaya Juan-Manuel
- Ang Mark Angelo C.
- Aomar Ismael F.
- Argumanis Luis E.
- Auckland City Hospital
- Auckland District Health Board
- Australian Red Cross Lifeblood
- Averyanov Alexander
- Axfors Cathrine
- Azienda Ospedaliera - Universitaria Città della Salute e della Scienza di Torino
- Bahrain Defence Force Royal Medical Services
- Baklaushev Vladimir P.
- Balionis Olga
- Bangabandhu Sheikh Mujib Medical University
- Belgian Red Cross
- Benfield Thomas
- Berlin Institute of Health
- Berry Consultants
- Berry Scott
- Birocco Nadia
- Blood Bank Centro Medico Naval
- Blood Services Red Cross
- Bonifacio Lynn B.
- Bowen Asha C.
- Bown Abbie
- Box Hill Hospital
- Cabello-Gutierrez Carlos
- Camacho Bernardo
- Camacho-Ortiz Adrian
- Cambridge University Hospitals NHS Foundation Trust
- Campbell-Lee Sally
- Cao Damon H.
- Cardesa Ana
- Carnate Jose M.
- Castillo German Jr. J.
- Cavallo Rossana
- CENETEC (National Center for Health Technology Excellence)
- Centro Medico Naval
- Charles Darwin University
- Chowdhury Fazle R.
- Chowdhury Forhad U. H.
- CHU de Nîmes
- Ciccone Giovannino
- Cingolani Antonella
- Climacosa Fresthel Monica M.
- Clinica del Occidente
- Clinica Quiron
- Clinical Department Red Andaluza de Dise?o y Traslacion de Terapias Avanzadas
- Compernolle Veerle
- Complejo Hospitalario Torrecárdenas
- Cortez Carlo Francisco N.
- Costa Neto Abel
- Daly James
- Danielle Franca
- Davis Joshua S.
- De Rosa Francesco Giuseppe
- Denholm Justin T.
- Denkinger Claudia M.
- Department of Clinical Medicine
- Department of Haematology Centro Transfusional Tejidos y Celulas de Granada
- Department of Haematology Monash Health
- Department of Infectious Diseases
- Department of Infectious Diseases Centro Transfusional Tejidos y Celulas de Sevilla
- Desmecht Daniel
- Dhaka Medical College and Hospital
- Donneau Anne-Françoise
- Dumagay Teresita E.
- Dunachie Susanna
- Dungog Cecile C.
- Díaz Ponce-Medrano Juan A.
- Díaz-Coronado Juan C.
- D’Antico Sergio
- Erinoso Olufemi
- Escasa Ivy Mae S.
- Estcourt Lise J.
- Evans Amy
- Evasan Agnes L. M.
- Fareli Christian J.
- Federal Medical-Biological Agency
- Fernandez-Sanchez Veronica
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
- Galassi Claudia
- Gallo Juan E.
- Garcia Jesus A.
- Garcia Patricia J.
- Garcia Patricia L.
- Garigliany Mutien
- Garza-Gonzalez Elvira
- Gauiran Deonne Thaddeus V.
- Gaviria García Paula A.
- George Washington University
- Ghent University
- Giron-Gonzalez Jose-Antonio
- Goethe University Frankfurt
- Goodman Steven N.
- Gordon Anthony C.
- Gothot André
- Grass Guaqueta Jeser Santiago
- Green Cameron
- Grimaldi David
- Gómez-Almaguer David
- Haber Noah A.
- Hammond Naomi E.
- Harvala Heli
- Heidelberg University
- Hemkens Lars G.
- Henry Ford Health System
- Heralde Francisco M.
- Herrick Jesica
- Higgins Alisa M.
- Hills Thomas E.
- Hines Jennifer
- Holm Karin
- Hoque Ashraful
- Hospital Costa Del Sol
- Hospital General de Mexico
- Hospital Nacional Hipolito Unanue
- Hospital Regional Universitario Carlos Haya
- Hospital San Juan de Dios del Aljarafe
- Hospital Universitario de Jerez de La Frontera
- Hospital Universitario de Valme
- Hospital Universitario Juan Ramon Jimenez
- Hospital Universitario Mayor Méderi
- Hospital Universitario San Cecilio
- Hospital Universitario Virgen de las Nieves
- Hospital Universitario Virgen del Rocio
- Hospital Universitario Virgen Macarena
- Hoste Eric
- Ignacio Jose M.
- Imperial College Healthcare NHS Trust
- Imperial College London
- Institute of Clinical Pathology and Medical Research
- Instituto D'or de Pesquisa e Ensino
- Instituto Distrital de Ciencia Biotecnolog?a e Investigaci?n en Salud (IDCBIS)
- Instituto Nacional de Enfermedades Respiratorias
- Intensive Care Medicine Alfred Health
- Intensive Care National Audit and Research Centre
- Ioannidis John P. A.
- Ivanov Alexander V.
- Janiaud Perrine
- Janssen Maike
- Jennings Jeffrey H.
- Jha Vivekanand
- Khanna Nina
- King's College London
- King Ruby Anne N.
- Kjeldsen-Kragh Jens
- Klenerman Paul
- Klinik Medicin og Akut
- Kotecha Aditya
- Krapp Fiorella
- KU Leuven
- Labanca Luciana
- Lagos State Ministry of Health
- Lagos State University
- Laing Emma
- Landin-Olsson Mona
- Laterre Pierre-François
- Lim Jodor
- Lim Lyn-Li
- Ljungquist Oskar
- Llaca-Díaz Jorge M.
- Lopez-Plaza Ileana
- Lucero Josephine Anne C.
- Lund University
- Lundgren Maria
- López-Cárdenas Salvador
- López-Robles Concepción
- Macías Juan
- Maganito Sandy C.
- Malundo Anna Flor G.
- Manipal Academy of Higher Education
- Manrique Rubén D.
- Manzini Paola M.
- Marcos Miguel
- Marquez Ignacio
- Martínez-Marcos Francisco Javier
- Mata Ana M.
- McArthur Colin J.
- McQuilten Zoe K.
- McVerry Bryan J.
- Medical Research Institute of New Zealand
- Medical Team National Task Force for Combating the Coronavirus (COVID19)
- Menon David K.
- Meyfroidt Geert
- Middlemore Hospital
- Ministerio de Salud del Perú
- Ministry of Health Kingdom of Bahrain
- Mirasol Ma. Angelina L.
- Misset Benoît
- Mohammed Bin Khalifa Cardiac Centre
- Moher David
- Molton James S.
- Monash University
- Mondragon Alric V.
- Monsalve Diana M.
- Moradi Choghakabodi Parastoo
- Morpeth Susan C.
- Mouncey Paul R.
- Moutschen Michel
- Murphy Erin
- Müller-Tidow Carsten
- Najdovski Tome
- NHS Blood and Transplant
- Nichol Alistair D.
- Nielsen Henrik
- Novak Richard M.
- Olalla Julian
- Osibogun Akin
- Osikomaiya Bodunrin
- Oxford University Hospitals NHS Foundation Trust
- Oyonarte Salvador
- O’Sullivan Matthew V. N.
- Pardo-Oviedo Juan M.
- Patel Mahesh C.
- Paterson David L.
- Perez-Calatayud Angel A.
- Perkina Anastasia
- Perry Naomi
- Perth Children?s Hospital
- Peña-Perez Carlos A.
- Philippine General Hospital
- Pouladzadeh Mandana
- Poyato Inmaculada
- Price David J.
- Public Health England
- Pérez-Alba Eduardo
- Quero Anne Kristine H.
- Rahman Md. M.
- Rahman Md. S.
- Ramesh Mayur
- Ramírez-Santana Carolina
- Rasmussen Magnus
- Rees Megan A.
- Rego Eduardo
- Roberts David J.
- Roberts Jason A.
- Rodríguez Yhojan
- Rodríguez-Baño Jesús
- Rogers Benjamin A.
- Rojas Manuel
- Romero Alberto
- Rowan Kathryn M.
- Royal Brisbane & Women's Hospital
- Royal College of Surgeons in Ireland-Medical University in Bahrain
- Royal Melbourne Hospital
- Russian Academy of Sciences
- Saccona Fabio
- Safdarian Mehdi
- Santos Maria Clariza M.
- Sasadeusz Joe
- Schmitt Andreas M.
- Scozzari Gitana
- Servicio de Hemoterapia y Banco de Sangre Instituto Nacional de Salud del Niño San Borja
- Shankar-Hari Manu
- Sharma Gorav
- Sheikh Hasina National Institute of Burn and Plastic Surgery
- Sjællands Universitetshospital
- Smith Emily R.
- Snelling Thomas
- Soto Alonso
- St John of God Health Care
- Stanford University
- Sydney Children?s Hospital Network
- Tagayuna Pedrito Y.
- Tang Amy
- Tatem Geneva
- Telethon Kids Institute
- Teofili Luciana
- The Faculty of Medicine
- The George Institute for Global Health
- The Peter Doherty Institute for Infection and Immunity
- Tong Steven Y. C.
- Turgeon Alexis F.
- Universidad Autonoma de Nuevo Leon
- Universidad CES
- Universidad del Rosario
- Universidad Nacional Autónoma de México
- Universidad Peruana Cayetano Heredia
- Universidad Ricardo Palma
- University and Regional Laboratories
- University College Dublin
- University Hospital Basel
- University of Amsterdam
- University of Basel
- University of Copenhagen
- University of Cádiz
- University of Illinois at Chicago
- University of Lagos
- University of Liege
- University of Manitoba
- University of Melbourne
- University of New South Wales
- University of Ottawa
- University of Oxford
- University of Pittsburgh
- University of Queensland
- University of Seville
- University of Sydney
- University of the Philippines
- University of Western Australia
- Université catholique de Louvain
- Université Laval
- Université libre de Bruxelles
- Uppsala University
- van’t Hooft Janneke
- Veloso Januario D.
- Venkatesh Balasubramanian
- Ventura-Enriquez Yanet
- Victorian Infectious Diseases Reference Laboratory
- Webb Steve A.
- Western Health
- Westmead Hospital
- Wiese Lothar
- Wikén Christian
- Wood Erica M.
- Yusubalieva Gaukhar M.
- Zacharowski Kai
- Zarychanski Ryan
- Publication venue
- Figshare
- Publication date
- 01/01/2021
- Field of study
Abstract Background Convalescent plasma has been widely used to treat COVID-19 and is under investigation in numerous randomized clinical trials, but results are publicly available only for a small number of trials. The objective of this study was to assess the benefits of convalescent plasma treatment compared to placebo or no treatment and all-cause mortality in patients with COVID-19, using data from all available randomized clinical trials, including unpublished and ongoing trials (Open Science Framework, https://doi.org/10.17605/OSF.IO/GEHFX ). Methods In this collaborative systematic review and meta-analysis, clinical trial registries (ClinicalTrials.gov, WHO International Clinical Trials Registry Platform), the Cochrane COVID-19 register, the LOVE database, and PubMed were searched until April 8, 2021. Investigators of trials registered by March 1, 2021, without published results were contacted via email. Eligible were ongoing, discontinued and completed randomized clinical trials that compared convalescent plasma with placebo or no treatment in COVID-19 patients, regardless of setting or treatment schedule. Aggregated mortality data were extracted from publications or provided by investigators of unpublished trials and combined using the Hartung–Knapp–Sidik–Jonkman random effects model. We investigated the contribution of unpublished trials to the overall evidence. Results A total of 16,477 patients were included in 33 trials (20 unpublished with 3190 patients, 13 published with 13,287 patients). 32 trials enrolled only hospitalized patients (including 3 with only intensive care unit patients). Risk of bias was low for 29/33 trials. Of 8495 patients who received convalescent plasma, 1997 died (23%), and of 7982 control patients, 1952 died (24%). The combined risk ratio for all-cause mortality was 0.97 (95% confidence interval: 0.92; 1.02) with between-study heterogeneity not beyond chance (I2 = 0%). The RECOVERY trial had 69.8% and the unpublished evidence 25.3% of the weight in the meta-analysis. Conclusions Convalescent plasma treatment of patients with COVID-19 did not reduce all-cause mortality. These results provide strong evidence that convalescent plasma treatment for patients with COVID-19 should not be used outside of randomized trials. Evidence synthesis from collaborations among trial investigators can inform both evidence generation and evidence application in patient care
Association between convalescent plasma treatment and mortality in COVID-19: a collaborative systematic review and meta-analysis of randomized clinical trials
- Author
- Aalborg University
- Aalborg University Hospital
- Abayomi Akin
- Abduljalil Manal
- Abdulrahman Abdulkarim
- Acosta-Ampudia Yeny
- Aguilar-Guisado Manuela
- Ahvaz Jundishapur University of Medical Sciences
- Al-Beidh Farah
- Alejandria Marissa M.
- Alfonso Rachelle N.
- Ali Mohammad
- AlQahtani Manaf
- AlZamrooni Alaa
- Anaya Juan-Manuel
- Ang Mark Angelo C.
- Aomar Ismael F.
- Argumanis Luis E.
- Auckland City Hospital
- Australian Red Cross Lifeblood
- Averyanov Alexander
- Axfors Cathrine
- Azienda Ospedaliera - Universitaria Città della Salute e della Scienza di Torino
- Bahrain Defence Force Royal Medical Services
- Baklaushev Vladimir P.
- Balionis Olga
- Bangabandhu Sheikh Mujib Medical University
- Belgian Red Cross
- Benfield Thomas
- Berlin Institute of Health
- Berry Consultants
- Berry Scott
- Birocco Nadia
- Blood Bank Centro Medico Naval
- Blood Services Red Cross
- Bonifacio Lynn B.
- Bowen Asha C.
- Bown Abbie
- Box Hill Hospital
- Cabello-Gutierrez Carlos
- Camacho Bernardo
- Camacho-Ortiz Adrian
- Campbell-Lee Sally
- Cao Damon H.
- Cardesa Ana
- Carnate Jose M.
- Castillo German Jr. J.
- Cavallo Rossana
- CENETEC (National Center for Health Technology Excellence)
- Centro Medico Naval
- Charles Darwin University
- Chowdhury Fazle R.
- Chowdhury Forhad U. H.
- CHU de Nîmes
- Ciccone Giovannino
- Cingolani Antonella
- Climacosa Fresthel Monica M.
- Clinica del Occidente
- Clinica Quiron
- Clinical Department Red Andaluza de Dise?o y Traslacion de Terapias Avanzadas
- Compernolle Veerle
- Complejo Hospitalario Torrecárdenas
- Cortez Carlo Francisco N.
- Costa Neto Abel
- Daly James
- Danielle Franca
- Davis Joshua S.
- De Rosa Francesco Giuseppe
- Denholm Justin T.
- Denkinger Claudia M.
- Department of Clinical Medicine
- Department of Haematology Centro Transfusional Tejidos y Celulas de Granada
- Department of Haematology Monash Health
- Department of Infectious Diseases
- Department of Infectious Diseases Centro Transfusional Tejidos y Celulas de Sevilla
- Desmecht Daniel
- Dhaka Medical College and Hospital
- Donneau Anne-Françoise
- Dumagay Teresita E.
- Dunachie Susanna
- Dungog Cecile C.
- Díaz Ponce-Medrano Juan A.
- Díaz-Coronado Juan C.
- D’Antico Sergio
- Erinoso Olufemi
- Escasa Ivy Mae S.
- Estcourt Lise J.
- Evans Amy
- Evasan Agnes L. M.
- Fareli Christian J.
- Federal Medical-Biological Agency
- Fernandez-Sanchez Veronica
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
- Galassi Claudia
- Gallo Juan E.
- Garcia Jesus A.
- Garcia Patricia J.
- Garcia Patricia L.
- Garigliany Mutien
- Garza-Gonzalez Elvira
- Gauiran Deonne Thaddeus V.
- Gaviria García Paula A.
- George Washington University
- Ghent University
- Giron-Gonzalez Jose-Antonio
- Goethe University Frankfurt
- Goodman Steven N.
- Gordon Anthony C.
- Gothot André
- Grass Guaqueta Jeser Santiago
- Green Cameron
- Grimaldi David
- Gómez-Almaguer David
- Haber Noah A.
- Hammond Naomi E.
- Harvala Heli
- Heidelberg University
- Hemkens Lars G.
- Henry Ford Health System
- Heralde Francisco M.
- Herrick Jesica
- Higgins Alisa M.
- Hills Thomas E.
- Hines Jennifer
- Holm Karin
- Hoque Ashraful
- Hospital Costa Del Sol
- Hospital General de Mexico
- Hospital Nacional Hipolito Unanue
- Hospital Regional Universitario Carlos Haya
- Hospital San Juan de Dios del Aljarafe
- Hospital Universitario de Jerez de La Frontera
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- Intensive Care Medicine Alfred Health
- Intensive Care National Audit and Research Centre
- Ioannidis John P. A.
- Ivanov Alexander V.
- Janiaud Perrine
- Janssen Maike
- Jennings Jeffrey H.
- Jha Vivekanand
- Khanna Nina
- King's College London
- King Ruby Anne N.
- Kjeldsen-Kragh Jens
- Klenerman Paul
- Klinik Medicin og Akut
- Kotecha Aditya
- Krapp Fiorella
- KU Leuven
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- Lagos State Ministry of Health
- Lagos State University
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- Landin-Olsson Mona
- Laterre Pierre-François
- Lim Jodor
- Lim Lyn-Li
- Ljungquist Oskar
- Llaca-Díaz Jorge M.
- Lopez-Plaza Ileana
- Lucero Josephine Anne C.
- Lund University
- Lundgren Maria
- López-Cárdenas Salvador
- López-Robles Concepción
- Macías Juan
- Maganito Sandy C.
- Malundo Anna Flor G.
- Manipal Academy of Higher Education
- Manrique Rubén D.
- Manzini Paola M.
- Marcos Miguel
- Marquez Ignacio
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- Mata Ana M.
- McArthur Colin J.
- McQuilten Zoe K.
- McVerry Bryan J.
- Medical Research Institute of New Zealand
- Medical Team National Task Force for Combating the Coronavirus (COVID19)
- Menon David K.
- Meyfroidt Geert
- Middlemore Hospital
- Ministerio de Salud del Perú
- Ministry of Health Kingdom of Bahrain
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- Misset Benoît
- Mohammed Bin Khalifa Cardiac Centre
- Moher David
- Molton James S.
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- Mondragon Alric V.
- Monsalve Diana M.
- Moradi Choghakabodi Parastoo
- Morpeth Susan C.
- Mouncey Paul R.
- Moutschen Michel
- Murphy Erin
- Müller-Tidow Carsten
- Najdovski Tome
- NHS Blood and Transplant
- Nichol Alistair D.
- Nielsen Henrik
- Novak Richard M.
- Olalla Julian
- Osibogun Akin
- Osikomaiya Bodunrin
- Oxford University Hospitals NHS Foundation Trust
- Oyonarte Salvador
- O’Sullivan Matthew V. N.
- Pardo-Oviedo Juan M.
- Patel Mahesh C.
- Paterson David L.
- Perez-Calatayud Angel A.
- Perkina Anastasia
- Perry Naomi
- Perth Children?s Hospital
- Peña-Perez Carlos A.
- Philippine General Hospital
- Pouladzadeh Mandana
- Poyato Inmaculada
- Price David J.
- Public Health England
- Pérez-Alba Eduardo
- Quero Anne Kristine H.
- Rahman Md. M.
- Rahman Md. S.
- Ramesh Mayur
- Ramírez-Santana Carolina
- RAS - Engelhardt Institute of Molecular Biology
- Rasmussen Magnus
- Rees Megan A.
- Rego Eduardo
- Roberts David J.
- Roberts Jason A.
- Rodríguez Yhojan
- Rodríguez-Baño Jesús
- Rogers Benjamin A.
- Rojas Manuel
- Romero Alberto
- Rowan Kathryn M.
- Royal Brisbane and Women's Hospital
- Royal College of Surgeons in Ireland-Medical University in Bahrain
- Royal Melbourne Hospital
- Saccona Fabio
- Safdarian Mehdi
- Santos Maria Clariza M.
- Sasadeusz Joe
- Schmitt Andreas M.
- Scozzari Gitana
- Servicio de Hemoterapia y Banco de Sangre Instituto Nacional de Salud del Niño San Borja
- Shankar-Hari Manu
- Sharma Gorav
- Sheikh Hasina National Institute of Burn and Plastic Surgery
- Sjællands Universitetshospital
- Smith Emily R.
- Snelling Thomas
- Soto Alonso
- St John of God Health Care
- St. Thomas' Hospital
- Stanford University
- Tagayuna Pedrito Y.
- Tang Amy
- Tatem Geneva
- Telethon Kids Institute
- Teofili Luciana
- The Children's Hospital at Westmead
- The Faculty of Medicine
- The George Institute for Global Health
- The Peter Doherty Institute for Infection and Immunity
- Tong Steven Y. C.
- Turgeon Alexis F.
- Universidad Autonoma de Nuevo Leon
- Universidad CES
- Universidad del Rosario
- Universidad Nacional Autónoma de México
- Universidad Peruana Cayetano Heredia
- Universidad Ricardo Palma
- University and Regional Laboratories
- University College Dublin
- University Hospital Basel
- University of Amsterdam
- University of Basel
- University of Cambridge
- University of Copenhagen
- University of Illinois at Chicago
- University of Lagos
- University of Liege
- University of Manitoba
- University of Melbourne
- University of New South Wales
- University of Ottawa
- University of Oxford
- University of Pittsburgh
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- University of Seville
- University of Sydney
- University of the Philippines
- University of Western Australia
- Université catholique de Louvain
- Université Laval
- Université libre de Bruxelles
- Uppsala University
- van’t Hooft Janneke
- Veloso Januario D.
- Venkatesh Balasubramanian
- Ventura-Enriquez Yanet
- Victorian Infectious Diseases Reference Laboratory
- Webb Steve A.
- Western Health
- Westmead Hospital
- Wiese Lothar
- Wikén Christian
- Wood Erica M.
- Yusubalieva Gaukhar M.
- Zacharowski Kai
- Zarychanski Ryan
- Publication venue
- Figshare
- Publication date
- 01/01/2021
- Field of study
Abstract Background Convalescent plasma has been widely used to treat COVID-19 and is under investigation in numerous randomized clinical trials, but results are publicly available only for a small number of trials. The objective of this study was to assess the benefits of convalescent plasma treatment compared to placebo or no treatment and all-cause mortality in patients with COVID-19, using data from all available randomized clinical trials, including unpublished and ongoing trials (Open Science Framework, https://doi.org/10.17605/OSF.IO/GEHFX ). Methods In this collaborative systematic review and meta-analysis, clinical trial registries (ClinicalTrials.gov, WHO International Clinical Trials Registry Platform), the Cochrane COVID-19 register, the LOVE database, and PubMed were searched until April 8, 2021. Investigators of trials registered by March 1, 2021, without published results were contacted via email. Eligible were ongoing, discontinued and completed randomized clinical trials that compared convalescent plasma with placebo or no treatment in COVID-19 patients, regardless of setting or treatment schedule. Aggregated mortality data were extracted from publications or provided by investigators of unpublished trials and combined using the Hartung–Knapp–Sidik–Jonkman random effects model. We investigated the contribution of unpublished trials to the overall evidence. Results A total of 16,477 patients were included in 33 trials (20 unpublished with 3190 patients, 13 published with 13,287 patients). 32 trials enrolled only hospitalized patients (including 3 with only intensive care unit patients). Risk of bias was low for 29/33 trials. Of 8495 patients who received convalescent plasma, 1997 died (23%), and of 7982 control patients, 1952 died (24%). The combined risk ratio for all-cause mortality was 0.97 (95% confidence interval: 0.92; 1.02) with between-study heterogeneity not beyond chance (I2 = 0%). The RECOVERY trial had 69.8% and the unpublished evidence 25.3% of the weight in the meta-analysis. Conclusions Convalescent plasma treatment of patients with COVID-19 did not reduce all-cause mortality. These results provide strong evidence that convalescent plasma treatment for patients with COVID-19 should not be used outside of randomized trials. Evidence synthesis from collaborations among trial investigators can inform both evidence generation and evidence application in patient care
Ultralight vector dark matter search using data from the KAGRA O3GK run
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- Yaala M. Ben
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- Yamamoto T.S
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- Yarbrough Z
- Yeh S.-W
- Yelikar A.B
- Yeung S.M.C
- Yin X
- Yokoyama J
- Yokozawa T
- Yoo J
- Yu H
- Yuzurihara H
- Zadrożny A
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- Zanolin M
- Zeeshan M
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- Zevin M
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- Zhao Yue
- Zhao Yuhang
- Zheng Y
- Zhong H
- Zhong S
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- Zhu Z.-H
- Zucker M.E
- Zweizig J
- Publication venue
- HAL CCSD
- Publication date
- 23/04/2024
- Field of study
International audienceAmong the various candidates for dark matter (DM), ultralight vector DM can be probed by laser interferometric gravitational wave detectors through the measurement of oscillating length changes in the arm cavities. In this context, KAGRA has a unique feature due to differing compositions of its mirrors, enhancing the signal of vector DM in the length change in the auxiliary channels. Here we present the result of a search for U(1)B−L gauge boson DM using the KAGRA data from auxiliary length channels during the first joint observation run together with GEO600. By applying our search pipeline, which takes into account the stochastic nature of ultralight DM, upper bounds on the coupling strength between the U(1)B−L gauge boson and ordinary matter are obtained for a range of DM masses. While our constraints are less stringent than those derived from previous experiments, this study demonstrates the applicability of our method to the lower-mass vector DM search, which is made difficult in this measurement by the short observation time compared to the auto-correlation time scale of DM