134 research outputs found
A roadmap to identifying and filling shortfalls in Neotropical ornithology
- Author
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 21/08/2020
- Field of study
Abstract Securing the long-term resilience of the worldâs most speciose avifauna, that of the Neotropics, requires spatially and temporally explicit data to inform decisions. We examine gaps in our knowledge of the regionâs avifauna through the lens of the biodiversity shortfall concept: the gaps between realized knowledge and complete knowledge. This framework serves as a useful tool to take stock of the last 25 yr of Neotropical ornithological work since the untimely death of Ted Parker. Here, we highlight 7 key shortfalls: taxonomy, distribution, abundance, evolutionary patterns, abiotic tolerances, species traits, and biotic interactions. We then propose an eighthâand newââParkerianâ shortfall that reflects a lack of basic natural history knowledge key to understanding how species might respond to environmental challenges. Bridging this shortfall will help reverse declines by informing reintroduction, recovery network, and habitat restoration efforts. We discuss the challenges imposed by each shortfall and how strategies such as citizen-science initiatives and technological advances can either remedy or mitigate the uncertainty they generate
Search for dark matter produced in association with bottom or top quarks in âs = 13 TeV pp collisions with the ATLAS detector
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- Aaboud Morad
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- Yamamoto Shimpei
- Yamanaka Takashi
- Yamane Fumiya
- Yamatani Masahiro
- Yamazaki Tomohiro
- Yamazaki Yuji
- Yan Zhen
- Yang Haijun
- Yang Hongtao
- Yang Yi
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- Yao Weiming
- Yap Yee
- Yasu Yoshiji
- Yatsenko Elena
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- Ye Shuwei
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- Yigitbasi Efe
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- Zanzi Daniele
- Zeitnitz Christian
- Zemaityte Gabija
- Zemla Andrzej
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- Zhang Ruiqi
- Zhang Xueyao
- Zhang Yu
- Zhang Zhiqing
- Zhao Xiandong
- Zhao Yongke
- Zhao Zhengguo
- Zhemchugov Alexey
- Zhou Bing
- Zhou Chen
- Zhou Li
- Zhou Maosen
- Zhou Mingliang
- Zhou Ning
- Zhou You
- Zhu Cheng
- Zhu Hongbo
- Zhu Junjie
- Zhu Yingchun
- Zhuang Xuai
- Zhukov Konstantin
- Zibell Andre
- Zieminska Daria
- Zimine Nikolai
- Zimmermann Christoph
- Zimmermann Stephanie
- Zinonos Zinonas
- Zinser Markus
- Ziolkowski Michael
- Zobernig Georg
- Zoccoli Antonio
- Zou Rui
- zur Nedden Martin
- Zwalinski Lukasz
- Ă kesson Torsten
- Ć filigoj Tina
- ĆœeniĆĄ Tibor
- ĆœivkoviÄ Lidija
- Îlvarez Piqueras DamiĂĄn
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fbâ1 of protonâproton collision data recorded by the ATLAS experiment at âs = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements
Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans
- Author
- Abbasi Z
- Abdul-Hamid M Akhlil
- Abel Paul D
- Abrams Paul H
- Adab Fawzi A
- Adamson Andrew
- Adeyoju A
- Adolfson Jan
- Afzal Naveed
- Ahiaku Ernest K N
- Ahmed Munir
- Al Sudani Mohammed L
- Al-Samarraie Amir S M
- Al-Samerraie [Unknown]
- Al-Singary Waleed
- Al-Sudani [Unknown]
- Alcock Christopher
- Alexander Kimberly
- Ali Zulfiqar
- Almond David J
- Alonzi Roberto
- Aly Markus
- Amin Al Olama Ali
- Anderson John
- Andrews Henry
- Andrews Steven
- Anjum Iqbal
- Anson Ken
- Anyamene Nicola A
- Apakama Ike
- Aparcia F
- Archbold J A A
- Arndt Volker
- Ash D
- Ashford Richard F U
- Auvinen Anssi
- Azzabi A
- Badenoch David
- Bahl Amit
- Bailey Karen
- Bailey M J
- Ball Andrew J
- Banerjee G
- Barber Jim
- Barber N
- Baria [Unknown]
- Barnes Douglas G
- Barros-Silva Joao
- Barwell Julian
- Bashir J
- Basu Pradip
- Bates Christopher A
- Batra Jyotsna
- Bax N A
- Baxter-Smith D
- Bdesha Amar
- Beacock Christopher J M
- Beaney Ronald P
- Beard Ralph
- Beatty John D
- Beck Rupert
- Beese Gail
- Beesley Sharon
- Bell C Richard W
- Bellringer James
- Benlloch Garcia Sara
- Benson Richard
- Beresford [Unknown]
- Bevis Christopher R A
- Bhana Rajanee
- Bhanot S
- Bhatnagar A
- Bhatt R I
- Birch Brian
- Birtle Alison
- Bishop M
- Biyani C Shekhar
- Blacklock A R E
- Blades Rosemary
- Bliss Peter
- Bloomfield David J
- Boddy S
- Bollina Prasad
- Bonnington Sue
- Booth C M
- Bose Pradeep
- Bott Michael C
- Bottomley David
- Boucher Nigel R
- Bowen J
- Bower Mark
- Bowsher W G
- Boyd P J R
- Bradshaw Lynne
- Bramble F James
- Brenner Hermann
- Brewster Simon F
- Briggs Tim
- Brock Cathryn
- Brock Sue
- Bromage Stephen
- Broms Michael
- Brough Richard
- Brown Andrew A
- Brown Paul
- Brown Paul M
- Brown Richard
- Brown Stephen
- Browning Tony J
- Bryan N
- Burgess Neil A
- Burns-Cox Nicholas
- Butterbach Katja
- Butterworth Paul C
- Cahill D
- Callaghan P S
- Calleary John
- Calleja M
- Calman Frances
- Camilleri Philip
- Campbell Alister
- Cannon Andrea
- Cannon-Albright Lisa
- Carnell Dawn M
- Carr T W
- Carter Adam C
- Carter Charles J M
- Carter Simon
- Castle Bruce M
- Catto James
- Cavalli-Bjoerkman Carin
- Chadwick David
- Chahal Rohit
- Chakraborti P
- Chappell [Unknown]
- Charig C
- Chetiyawardana Anula D
- Chilton Christopher
- Chinegwundoh F I
- Chong Irene
- Choudhury Ananya
- Chow Wai-Man
- Christmas Timothy J
- Christova Svetlana
- Churn Mark J
- Cieza-Borrella Clara
- Clarke Noel W
- Clavijo-Eisele Jorge
- Clements Judith A
- Coe M
- Coetzee Gerhard A
- Cohen N P
- Coker C
- Cole David J
- Cole O
- Cole Trevor
- Collins Angus
- Collins Gerald
- Collinson Matthew
- Conn I
- Connell C
- Conti David V
- Cook Audrey
- Cook Margaret
- Cooke Peter
- Cooksey Graeme
- Coombs L
- Cooper Debbie
- Copland Robert F
- Cornaby Andrew J
- Cornford P A
- Corolis [Unknown]
- Corr John
- Costello C B
- Coull Mrs N
- Cowan Richard
- Cox Angela
- Cox Robert
- Coyle C
- Crew Jeremy
- Crisp John C
- Cross W
- Cruger Dorthe
- Crundwell Malcolm
- Cummings [Unknown]
- Cybulski Cezary
- Dadaev Tokhir
- Dahar Nazeer
- Daniel Francis N
- Darrad J
- Daruwala Pallon
- Das Gautam
- Datta Shibendra
- Davidson S
- Davies Joseph
- Davis Michael
- Davison Owen W
- Dawkins Guy
- Dawson Chris
- De Bolla Alan R
- Dearnaley David
- Desai Ken M
- Deutsch George P
- Dick John
- Dickinson Andrew J
- Dickson Jeanette
- Dikov Tihomir
- Dinneen Michael
- Dixit Sanjay
- Dobbs H Jane
- Doble A
- Doble Andrew
- Dodds David
- Doherty Alan
- Donaldson P
- Donovan Jenny L
- Dooldeniya M
- Douglas S Fiona
- Down Liz
- Drake [Unknown]
- Duchesne Gill M
- Duffy Peter
- Dunn Michael
- Dunsmuir W D
- Durkan Garrett
- Durrani Sajid K
- Easton Douglas
- Eaton Alan C
- Eccles Diane
- Eckert Allison
- Eddy B
- Eden C D
- Edwards J
- Eeles Rosalind A
- El-Modir A
- Elkabir Jeremy
- Elliott Emma
- Elliott P Tony
- Ellis B W
- Ellis R
- Elves Andrew W S
- Elwell Christine
- Emberton Mark
- Emmerson Louise
- England Roland C D
- Errington R D
- Evans D Gareth
- Falconer Alison
- Fawcett Derek
- Featherston C
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- Feggetter Jeremy
- Ferguson C
- Fermont D
- Ferro Michael
- Fisher Cyril
- Fitzgerald Liesel
- Fitzgerlad Liesel M
- Fletcher Matthew
- Folkes A
- Ford Trevor F
- Foster Paul W
- Franks Kevin N
- Freedman Mathew
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- Gale Joanna
- Gallegos Christopher
- Gelister James S
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- Ghana [Unknown]
- Gibbs Stephanie
- Gilbert Hugh
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- Gillatt David
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- Glass Jonathan M
- Glenister James
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- Govindasami Koveela
- Gower Richard L
- Graham John
- Green Damian
- Greenland Jonathan
- Grieve Robert
- Griffiths Thomas R L
- Gronberg Henrik
- Gujral Sandy
- Gupta Nishi
- Gurun Riza Murat
- Gustafsson Sven
- Guy Michelle
- Guy Peter J
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- Hazel Steve
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- Heathcote Peter
- Hehir Michael
- Hellawell Giles O
- Henderson Brian E
- Hendry David
- Henley Mike
- Henrique Rui
- Henry Ann
- Herbert Pippa
- Herkommer Kathleen
- Hetherington John
- Hickish Tamas
- Hicks James A
- Hilman Serena
- Hindley Richard
- Hindmarsh John R
- Hines John
- Hingorani M
- Ho Edwin T S
- Hodgson Shirley
- Hoffman U
- Holden David
- Holding Peter
- Hollingdale A
- Hollins Graham W
- Holmes Simon A V
- Holt Sarah
- Hopper John L
- Horan Gail
- Horwich Alan
- Hoskin Peter
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- Howson Joanne
- Hrouda D
- Huddart Robert
- Hudson Liz
- Hughes Michael
- Hughes Owen
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- Ibrahim A
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- Irving Stuart
- Irwin C
- Iversen Peter
- Izatt Louise
- Izegbu Victor
- Jameel Basharat
- James Michael J
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- James R Lester
- Javle Pradip
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- Jhavar Sameer
- Johansson Jan-Erik
- Jones Chris R
- Jones David A
- Jones Gareth
- Jones Mandy
- Joseph J
- Joss Shelagh
- Jugurnauth-Little Sara
- Kachakova Darina
- Kaisary Amir
- Kaliski Alexandre L
- Kaneva Radka
- Kapur G
- Karim O
- Karlsson Ami
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- Kedda Mary-Anne
- Keeley F X
- Kelkar Anand R
- Kelleher J P
- Kelly John
- Kenwrick Sue
- Kerr Kris
- Key Tim J
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- Khaw Kay-Tee
- Khoo Vincent
- Kibel Adam S
- Kierzek Andrzej
- Kimber Rachel M
- Kinder R
- Kirby Roger S
- Kirk David
- Kirkbride Peter
- Kirollos Magdi M
- Klarskov Peter
- Kluzniak Wojciech
- Kockelbergh Roger
- Koenig Philip C W C
- Kooiman Gordon G
- Koreich O
- Kote-Jarai Zsofia
- Koupparis Anthony
- Kourah Mohamed
- Kraus Sigurd
- Kujala Paula
- Kujawa Magda L
- Kulkarni Ravi
- Kumar M
- Kumar Rajeev
- Kunkler Ian H
- Kynaston H
- Kynaston Howard
- Lachlan Katherine L
- Laing Robert
- Lalloo Fiona
- Lancashire M
- Lane Athene
- Langley Stephen E M
- Laniado Marc
- Larner T R
- Lau Maurice W
- Lawrence W T
- Lawson Anne
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- Leader Mary
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- Lee J O
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- Lemburger R John
- Lennon Teresa
- Leone Priscilla
- Leongamornlert Daniel
- Lester Jason
- Leung Hing
- Lewis D Christopher
- Lewis J
- Li Qiuyan
- Lim Hui-Yi
- Lin Hui-Yi
- Liston Thomas
- Livni Naomi
- Livsey Jacqueline
- Lloyd S
- Locke Imogen
- Lodge Richard
- Logue John
- Longmuir Mark
- Lophatananon Artitaya
- Lophatonanon Artitaya
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- Lucas Malcolm G
- Luedeke Manuel
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- Lydon Anna
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- Lyons Norma
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- Macdonald [Unknown]
- Madaan Sanjeev
- Madhava Kudingila R
- Maeaettaenen Liisa
- Maguire Joseph
- Maher E R
- Mahmood Rana
- Maia Sofia
- Maier Christiane
- Mair Graeme H M
- Malone Greg
- Malone Peter R
- Mangar Stephen A
- Mantle Mark
- Mark I
- Marsden Gemma
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- Mason Malcolm
- Mason Robert
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- Matenhelia Shyam
- Matthews Philip N
- McAleese J
- McBride Donna
- Mcdonnell Shannon K
- McDonnell Shannon K
- McFarlane Jonathan
- McGrath [Unknown]
- McIlhenny Craig
- McInerney Paul
- McIntosh Gregor
- McKinna F
- McLaren Duncan
- McLarty Esther
- McMenemin Rhona
- McNeill Alan
- McNicholas T A
- Meddings Robert N
- Mee A David
- Melcher Lucinda
- Memon [Unknown]
- Menzes Pravin
- Michael Agnieszka
- Miller Marek
- Mills Robert
- Mitchell S
- Mitev Vanio
- Mithal Natasha
- Mitkova Atanaska
- Mitra Anita
- Mobb Gillian E
- Moffat Leslie E F
- Mokete [Unknown]
- Money-Kyrle Julian
- Montgomery Bruce
- Moody Hilary
- Moody Martin P
- Morgan Angela
- Morley Roland
- Morris Sean B
- Morrison Patrick
- Mort Diana
- Mostafid Amir H
- Motiwala Hanif
- Mufti Gulzar
- Muir Gordon
- Muir Kenneth
- Mumtaz Faiz
- Murphy Michael
- Murray Alexandra
- Murray Keith W
- Murrell Shirley
- Murtola Teemu
- Muthukumar D
- Naerger Harry
- Namasivayam Siva
- Nargund Vinod
- Nawrocki [Unknown]
- Neal David E
- Neilson Donald
- Nethersell A
- Newby Jacqueline C
- Newman Hugh
- Newton R
- Nielsen Sune F
- Nordestgaard BĂžrge G
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- O'Brien Tim S
- O'Donnell H
- O'Donoghue E
- O'Donoghue Neil
- O'Reilly P
- O'Rourke J S
- O'Sullivan Joe
- O'Sullivan Patricia
- Oakley Neil
- Ogden Chris
- Ohja Hemant
- Oliver Tim
- Omara Tracy
- Ong Eng K
- Osborn David
- Ostler Peter
- Owen J
- Palfrey Edward
- Panades Miguel
- Panakis Niki
- Pancharatnam M
- Pandha Hardev
- Pantelides Michalakis L
- Panwar U
- Parikh Omi
- Park Hyun
- Park Jong Y
- Parker Chris
- Parker Christopher H
- Parys Bohdan T
- Pascoe Sarah
- Pashayan Nora
- Patel Anup
- Paterson Joan
- Pathack S
- Pati Jhumur
- Patterson Helen
- Pattu [Unknown]
- Paul A
- Paul Alan
- Paulo Paula
- Payne Heather
- Peake David
- Pedersen John
- Pedley I
- Pengelly A
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- Perry Matthew
- Persad Raj
- Peters John
- Pharoah Paul
- Philp N H
- Philp T
- Pickering Lisa M
- Pigott Katharine
- Pinto Pedro
- Plail R
- Plowman P Nicholas
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- Prasad Seshadri Sri
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- Ragavan Narasimhan
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- Slavov Chavdar
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- Thurston A
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- Turner Megan
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- Tymrakiewicz Malgorzata
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- Urwin Graeme H
- Vale Justin A
- Van As [Unknown]
- Van As Nicholas
- Vasanthan Subramaniam
- Vesey Sean
- Vilarino-Varela Maria
- Violet John
- Virdi Jaspal
- Viñuela Ana
- Vlahova Aleksandrina
- Vogel Walther
- Wade Robert
- Wahlfors Tiina
- Waite Katherine
- Walker E M
- Walker Roger
- Wallace David M A
- Wallinder Hans
- Wang Liang
- Watkin Nicholas A
- Watson M E
- Waxman J H
- Waymont Brian
- Weaver Andrew
- Webb Ralph J
- Wedderburn Andrew
- Weischer Maren
- Wells Paula
- Wemyss-Holden G D
- Weston P M T
- Wheatley Duncan
- Whelan P
- Whillis D
- Whitmore Ian
- Wiklund Fredrik
- Wilde Adam D
- Wiles Vicki
- Wilkins Marie
- Wilkinson Rosemary
- Williams John H
- Williams Simon
- Willis Michael
- Wills Michael I
- Wilson J R
- Wilson Richard
- Winkler Mathias H
- Wise Marcus
- Wokozorczyk Dominika
- WokoĆorczyk Dominika
- Wood Glenn
- Woodhams Simon
- Woodhouse C
- Woodward Cathryn
- Woolf [Unknown]
- Woolfenden K A
- Worlding Jane
- Wright Mark
- Wu Huihai
- WYLIE [Unknown]
- Wylie James P
- Wynne Chris
- Yeadon Trina
- Zachariah Babu
- Zang Angelika
- Zarkar A
- Zheng Wei
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2015
- Field of study
Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have
fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in
25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16
regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of
correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP,
while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in
Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium
(LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region.
Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant
enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the
refined data for existing association signals, we estimate that these loci now explain âŒ38.9% of the familial relative risk of PrCa,
an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of
PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent
signals within the same regio
Genetic mechanisms of critical illness in COVID-19.
- Author
- A A Roger Thompson
- A Abraheem
- A Agasou
- A Ahmed
- A Ali
- A Allan
- A Altabaibeh
- A Alvaro
- A Aspinwall
- A Ayers
- A Bamford
- A Barron
- A Bashyal
- A Bellini
- A Bociek
- A Botello
- A Bowes
- A Brady
- A Brayne
- A Brown
- A Brown
- A Butler
- A Campbell
- A Carter
- A Collins
- A Cowley
- A Cowton
- A Cowton
- A Cox
- A Crew
- A Dance
- A Daniel
- A Daniels
- A Dela Rosa
- A Drummond
- A Durie
- A E Heron
- A Easthope
- A Easthope
- A Evans
- A Fofano
- A Gales
- A Ganesan
- A Gardner
- A Garg
- A Gherman
- A Gordon
- A Gratrix
- A Gulati
- A Gupta
- A Haigh
- A Haldeos
- A Harrison
- A Harvey
- A Hayes
- A Higham
- A Higham
- A Hilldrith
- A Holden
- A Hormis
- A Hutcheon
- A Javaid
- A Joseph
- A Kaliappan
- A Katary
- A Kay
- A Kayani
- A Kent
- A Kirkby
- A Knight
- A Kubisz-Pudelko
- A Kuravi
- A Lewis
- A Loveridge
- A Lyle
- A Mayer
- A McAlpine
- A McCarthy
- A McGregor
- A McGregor
- A Meikle
- A Mitchell
- A Mitra
- A Morris
- A Morrison
- A Naranjo
- A Nicholson
- A Nicholson
- A Nilsson
- A Noakes
- A Patel
- A Pickard
- A Poole
- A Price
- A Puxty
- A Quinn
- A Quinn
- A Raithatha
- A Rattray
- A Reddy
- A Reed
- A Reyes
- A Rose
- A Rose
- A Rostron
- A Roy
- A Roynon-Reed
- A S Raj
- A Salberg
- A Sanderson
- A Serrano-Ruiz
- A Solesbury
- A Sukha
- A Swain
- A Tariq
- A Thomas
- A Thomas
- A Todd
- A Tomas
- A Tridente
- A Tucci
- A Turnbull
- A Uriel
- A Ustianowski
- A Vochin
- A Vuylsteke
- A Waite
- A Walden
- A Whileman
- A Wilkinson
- A Williams
- A Williams
- A Wilson
- A Zak
- A Zaki
- Achille Iolascon
- Adam Auton
- Adam Brown
- Agnese Verzuri
- Agostino Ognibene
- Agostino Riva
- Ailsa Golightly
- Alan Maclean
- Alessandra
- Alessandra Stella
- Alessandra Vergori
- Alessia Giorli
- Alexander J Mentzer
- Alice Donati
- Alison M Meynert
- Alistair Nichol
- Ana da Silva Filipe
- Andrea Antinori
- Andrea Cossarizza
- Andrea Ganna
- Andrea Tommasi
- Andrew Rambaut
- Andrew Stenhouse
- Andy Law
- Anjali J Shastri
- Anna Canaccini
- Anna Maria Pinto
- Annarita Giliberti
- Annemarie B Docherty
- Antonella D'Arminio Monforte
- Antonia Ying Wai Ho
- Antonio Di Biagio
- Antony Symons
- Arianna Emiliozzi
- Arianna Gabrieli
- Audrey Coutts
- B Anwar
- B Attwood
- B Baines
- B Blackledge
- B Borislavova
- B Chandler
- B Charles
- B Creagh-Brown
- B David
- B Deacon
- B Deacon
- B Digby
- B Faulkner
- B Fuller
- B Gumbrill
- B Gurung
- B Hadebe
- B Hairsine
- B Hopkins
- B Johnston
- B Lenagh
- B Masunda
- B Ogg
- B Patel
- B Player
- B Purewal
- B Scholefield
- B Shelley
- B Sloan
- B Thomas
- B Wadams
- B Welsh
- B Wilkinson
- B Winter-Goodwin
- B Yates
- Baillie J Kenneth
- Barbara Rossetti
- Beale Rupert
- Beatrice Alex
- Benjamin Bach
- Bretherick Andrew D
- Bruno Frediani
- C Adams
- C Ahmed
- C Almaden-Boyle
- C Ashbrook-Raby
- C Basikolo
- C Battle
- C Beazley
- C Beith
- C Borra
- C Brandwood
- C Brantwood
- C Burnett
- C Castro Delgado
- C Clark
- C Clulow
- C Collins
- C Cruz
- C Davis
- C Demetriou
- C Dennis
- C Dexter
- C Downes
- C Dunmore
- C Eastgate
- C Eckbad
- C Finch
- C Gibson
- C Gorman
- C Hays
- C Hewitt
- C Holl
- C Howcroft
- C Humphrey
- C Jackson
- C Jardine
- C Jennings
- C Jones
- C Kaye
- C Lynch
- C Lyons
- C McCulloch
- C McParland
- C McParland
- C Murphy
- C Parmar
- C Pawley
- C Phillips
- C Phillips
- C Pothecary
- C Pothecary
- C Prendergast
- C Price
- C Rishton
- C Sell
- C Shovelton
- C Sicat
- C Stuart
- C Summers
- C Swan
- C Thompson
- C Thorpe
- C Tibke
- C Tierney
- C Vigurs
- C Wells
- C Whitton
- C Whyte
- C Wrey Brown
- Cameron J Fairfield
- Carmelo Piscopo
- Carmen Marciano
- Caroline Abernathy
- Carrol Gamble
- Caterina Lo Rizzo
- Catherine A Shaw
- Catherine H Weldon
- Caulfield Mark
- Ceilia Boz
- Cesira Nencioni
- Chelsea Ye
- Chiara Fallerini
- Chiara Gabbi
- Chiara Spertilli
- Chloe Donohue
- Chris Ponting
- Christoper A Green
- Cinthia E Jannes
- Clare Jackson
- Clohisey Sara
- Cristina Mussini
- D Antcliffe
- D Bakthavatsalam
- D Banach
- D Baptista
- D Bell
- D Branney
- D Brealey
- D Brealey
- D Butcher
- D Butcher
- D Childs
- D Clarke
- D Collier
- D Collier
- D Cristiano
- D Dawson
- D Donaldson
- D Duffin
- D Fottrell-Gould
- D Golden
- D Griffin
- D Hamilton
- D Hawcutt
- D Hope
- D Horner
- D Kallon
- D Kaye
- D Kelly
- D Loader
- D Lomas
- D Martin
- D McGlynn
- D McLaughlanv
- D Melia
- D Menzies
- D Mullan
- D Pogson
- D Potla
- D Potoczna
- D Purohit
- D Raynard
- D Salutous
- D Salutous
- D Scaletta
- D Shaw
- D Skinner
- D Smyth
- D Strachan
- D Tetla
- D Thornton
- D Trodd
- D Vedage
- D Walker
- D Warren
- D Williams
- D Wood
- D Wright
- Daniela Francisci
- Daniella Coker
- Danilo Tacconi
- David A van Heel
- David Bennet
- David L Robertson
- David Stuart
- Dawn Law
- Debby Bogaert
- Derek Murphy
- Domenico A Coviello
- E Abaleke
- E Allan
- E Anastasescu
- E Andrews
- E Apetri
- E B Jude
- E Beech
- E Beranova
- E Bevan
- E Black
- E Brinkworth
- E Collins
- E Combes
- E Davies
- E Dobson
- E Dooks
- E Fisher
- E Gendall
- E Goff
- E Goodwin
- E Gordon
- E Heeney
- E Horsley
- E Hughes
- E Johnson
- E Knights
- E Lee
- E London
- E Maccacari
- E Massey
- E McKenna
- E Meadows
- E Moncur
- E Morino
- E Mwaura
- E Peasgood
- E Perkins
- E Radford
- E Raith
- E Raith
- E Salciute
- E Smith
- E Smithson
- E Stoddard
- E Stones
- E Thomas
- E Tilney
- E Timlick
- E Treus Gude
- E Virgilio
- E Watson
- E Wilby
- Edoardo Conticini
- Egle Saviciute
- Elena Bargagli
- Elena Desanctis
- Elisa Benetti
- Elisa Frullanti
- Elisabetta Menatti
- Elisabetta Schiaroli
- Ellie Mcmaster
- Emma C Thomson
- Emmanuelle Marques
- Enrico Martinelli
- Esther Duncan
- Esther Merlini
- Ewen M Harrison
- F Anderson
- F Auld
- F Bibi
- F Davies
- F Farquhar
- F Fisher
- F Hurford
- F Kibutu
- F McNeela
- F Moore
- F Nasir
- F Trim
- F Wakinshaw
- F Williams
- Fabio Lena
- Fawkes Angie
- Federico Anedda
- Federico Franchi
- Ferdinando Giannattasio
- Filip Taneski
- Filippo Aucella
- Filippo Biscarini
- Floriana Valentino
- Fourman Max Head
- Francesca Andretta
- Francesca Fava
- Francesca Gatti
- Francesca Mari
- Francesca Montagnani
- Francesco Castelli
- Francesco Raimondi
- Furniss James
- G Andrew
- G Arbane
- G Bell
- G Bercades
- G Croston
- G Debreceni
- G Durrant
- G Hambrook
- G Hobden
- G Houston
- G Hughes
- G Jones
- G Lubimbi
- G Maloney
- G Martir
- G Millen
- G Mills
- G O'Connor
- G Padden
- G Randell
- G Sadera
- G Seddon
- G Sera Howe
- G Sloane
- G Subramanian
- G Tsinaslanidis
- G Turner
- G Watson
- G Wray
- Gabriella Coiro
- Gabriella Doddato
- Gail Carson
- Gardar Sveinbjornsson
- Gary Leeming
- Genni Spargi
- Georgios Pollakis
- Giacomo Zanelli
- Gian Piero Caldarelli
- Giancarlo Bosio
- Giuseppe Fiorentino
- Giuseppe Merla
- Gountouna Elvina
- Graham S Cooke
- Griffiths Fiona
- Grimes Graeme
- H Bancroft
- H Bates
- H Belfield
- H Blackman
- H Blakemore
- H Brooke
- H Button
- H Coles
- H Curgenven
- H Filipe
- H Fox
- H Golding
- H Hill
- H Holcombe
- H Houlden
- H Jeffrey
- H Kent
- H Langton
- H McGuinness
- H Meghari
- H Millward
- H Moore
- H Parker
- H Pearson
- H Prady
- H Quinn
- H Rangarajan
- H Rehman
- H Reschreiter
- H Riley
- H Sainsbury
- H Savill
- H Sturgeon
- H T-Michael
- H Tench
- H Tiveran
- H Turner
- H Whittle
- H Willis
- H Wood
- Haley Chris
- Hanning Mal
- Harrison David
- Hayley Hardwick
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- Stella Aslibekyan
- Stephanie Roberts
- Stephen R Knight
- Summers Charlotte
- Susanna Croci
- Susanna Guerrini
- T Anderson
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- T Martin
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- T Newman
- T Nortcliffe
- T O Jones
- T Pogreban
- T Rees
- T Samakomva
- T Smith
- T Smith
- T Szakmany
- T Varghes
- T Williams
- T Wood
- Tammy Gilchrist
- Tenesa Albert
- Teresa Filshtein-Sonmez
- Thomas M Drake
- Thushan de Silva
- Tim Walsh
- Tom Fletcher
- Tom Solomon
- Tony Wackett
- Trevor Paterson
- Tullio Trotta
- Turtle Lance
- U Poultney
- V Amin
- V Anumakonda
- V Bastion
- V Cannons
- V Crickmore
- V Gopal
- V Irvine
- V Kasipandian
- V Krishnamurthy
- V Lake
- V Linnett
- V Martinson
- V Nagarajan
- V Page
- V Parris
- V Parris
- V Pristopan
- V Ratnam
- V Rivers
- V Sarathy
- V Thomas
- V Thwaites
- V Tuckey
- V Turner
- V Wagstaff
- V Waugh
- Valentina Anemoli
- Vanessa Sancho-Shimizu
- Victoria Shaw
- Vitart Veronique
- W Harrison
- W Khaliq
- W Khaliq
- W McCormick
- W Woodyatt
- Walker Susan
- Walsh Timothy
- Wang Bo
- Wei Shen Lim
- Wendy S Barclay
- William A Paxton
- William Greenhalf
- Wilson James F
- Wrobel Nicola
- Wu Yang
- X Qiu
- Y Baird
- Y Choudhury
- Y Hussain
- Y Jackson
- Y Thirlwall
- Yang Jian
- Yang Zhijian
- Z Alldis
- Z Belagodu
- Z Bradshaw
- Z Coton
- Z Daly
- Z Farzad
- Z Fernandez
- Z Garland
- Z Maqsood
- Z Omar
- Z Prime
- Z Scott
- Zechner Marie
- Zhai Ranran
- Zheng Chenqing
- Publication venue
- Nature
- Publication date
- 01/01/2020
- Field of study
Host-mediated lung inflammation is present1, and drives mortality2, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development3. Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2,244 critically ill patients with COVID-19 from 208 UK intensive care units. We have identified and replicated the following new genome-wide significant associations: on chromosome 12q24.13 (rs10735079, PÂ =Â 1.65Â ĂÂ 10-8) in a gene cluster that encodes antiviral restriction enzyme activators (OAS1, OAS2 and OAS3); on chromosome 19p13.2 (rs74956615, PÂ =Â 2.3Â ĂÂ 10-8) near the gene that encodes tyrosine kinase 2 (TYK2); on chromosome 19p13.3 (rs2109069, PÂ =Â 3.98Â ĂÂ Â 10-12) within the gene that encodes dipeptidyl peptidase 9 (DPP9); and on chromosome 21q22.1 (rs2236757, PÂ =Â 4.99Â ĂÂ 10-8) in the interferon receptor gene IFNAR2. We identified potential targets for repurposing of licensed medications: using Mendelian randomization, we found evidence that low expression of IFNAR2, or high expression of TYK2, are associated with life-threatening disease; and transcriptome-wide association in lung tissue revealed that high expression of the monocyte-macrophage chemotactic receptor CCR2 is associated with severe COVID-19. Our results identify robust genetic signals relating to key host antiviral defence mechanisms and mediators of inflammatory organ damage in COVID-19. Both mechanisms may be amenable to targeted treatment with existing drugs. However, large-scale randomized clinical trials will be essential before any change to clinical practice
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity
- Author
- A. Abraheem
- A. Agasou
- A. Ahmed
- A. Ali
- A. Allan
- A. Altabaibeh
- A. Alvaro
- A. Aspinwall
- A. Ayers
- A. Bamford
- A. Barron
- A. Bashyal
- A. Bellini
- A. Bociek
- A. Botello
- A. Bowes
- A. Brady
- A. Brayne
- A. Brown
- A. Brown
- A. Butler
- A. Carter
- A. Collins
- A. Cowley
- A. Cowton
- A. Cowton
- A. Cox
- A. Crew
- A. Dance
- A. Daniel
- A. Daniels
- A. Dela Rosa
- A. Drummond
- A. Durie
- A. E. Heron
- A. Easthope
- A. Easthorpe
- A. Evans.
- A. Fofano
- A. Gales
- A. Ganesan
- A. Gardner
- A. Garg
- A. Gherman
- A. Gordon
- A. Gratrix
- A. Gulati
- A. Gupta
- A. Haigh
- A. Haldeos
- A. Harrison
- A. Harvey
- A. Hayes
- A. Higham
- A. Higham
- A. Hilldrith
- A. Holden
- A. Hormis
- A. Hutcheon
- A. Javaid
- A. Joseph
- A. Kaliappan
- A. Katary
- A. Kay
- A. Kayani
- A. Kent
- A. Kirkby
- A. Knight
- A. Kubisz-Pudelko
- A. Kuravi
- A. Lewis
- A. Loveridge
- A. Lyle
- A. Mayer
- A. McAlpine
- A. McCarthy
- A. McGregor
- A. McGregor
- A. Meikle
- A. Mitchell
- A. Mitra
- A. Morris
- A. Morrison
- A. Naranjo
- A. Nicholson
- A. Nicholson
- A. Noakes
- A. Patel
- A. Pickard
- A. Price
- A. Puxty
- A. Quinn
- A. Quinn
- A. Raithatha
- A. Rattray
- A. Reddy
- A. Reed
- A. Reyes
- A. Rose
- A. Rose
- A. Rostron
- A. Roy
- A. Roynon-Reed
- A. S. Raj
- A. Salberg
- A. Sanderson
- A. Serrano-Ruiz
- A. Solesbury
- A. Sukha
- A. Swain
- A. Tariq
- A. Thomas
- A. Thomas
- A. Todd
- A. Tomas
- A. Tridente
- A. Tucci
- A. Turnbull
- A. Uriel
- A. Ustianowski
- A. Vochin
- A. Vuylsteke
- A. Waite
- A. Walden
- A. Whileman
- A. Wilkinson
- A. Williams
- A. Williams
- A. Wilson
- A. Zak
- A. Zaki
- Achille Iolascon
- Adam Brown
- Adam KreÌštowski
- Adriana RozÌy
- Agnese Verzuri
- Agnieszka Adamek
- Agnieszka Bielska
- Agostino Ognibene
- Agostino Riva
- Ailsa Golightly
- Alan Maclean
- Albert Tenesa
- Aleksandra Berkan-Kawinska
- Aleksandra Jezela-Stanek
- Aleksandra Starosz
- Alessandra Guarnaccia
- Alessandra Renieri &
- Alessandra Stella
- Alessandra Vergori
- Alessandro Pancrazzi
- Alessia Giorli
- Alice Donati
- Alison Meynert
- Alistair Nichol
- Anders Larsson
- Andrea Antinori
- Andrea Cossarizza
- Andrea Gabbuti
- Andrea Tommasi
- Andrew D. Bretherick
- Andrew Law
- Andrew Stenhouse
- Andrzej Eljaszewicz
- Andrzej Horban
- Andy Law
- Angelica Pagliazzi
- Angie Fawkes
- Anke Hinney
- Anna Canaccini
- Anna Kruk
- Anna Maria Pinto
- Anna Moniuszko-Malinowska
- Anna Parfieniuk-Kowerda
- Anna Piekarska
- Anna SzaĆkowska
- Annarita Giliberti
- Anne Richmond
- Antonella D. âArminio Monforte
- Antonella Vincenti
- Antonia Ho
- Antonio Di Biagio
- Antonio Perrella
- Arianna Emiliozzi
- Arianna Gabrieli
- Arsalin Azzadin
- Asma Al Thani &
- Athanasios Kousathanas
- Audrey Coutts
- Axel Schmidt
- Axel Schmidt
- B. Anwar
- B. Attwood
- B. Baines
- B. Blackledge
- B. Borislavova
- B. Chandler
- B. Charles
- B. Creagh-Brown
- B. David
- B. Deacon
- B. Deacon
- B. Digby
- B. Faulkner
- B. Fuller
- B. Gumbrill
- B. Gurung
- B. Hadebe
- B. Hairsine
- B. Hopkins
- B. Johnson
- B. Lenagh
- B. Masunda
- B. Ogg
- B. Patel
- B. Player
- B. Purewal
- B. Scholefield
- B. Shelley
- B. Sloan
- B. Thomas
- B. Wadams
- B. Welsh
- B. Wilkinson
- B. Winter-Goodwin
- B. Yates
- Barbara Rossetti
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- S. Turney
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- S. Wadd
- S. Whiteley
- S. Williams
- S. Wood
- S. Yussuf
- Sabino Scolletta
- Sabrina Ravaglia
- Said I. Ismail
- Salam Massadeh
- Sandra Uszok
- Sandro Mancarella
- Sandro Panese
- Sara Amitrano
- Sara Bulow Anderberg
- Sara Clohisey
- Sara Clohisey
- Sara Clohisey Peter Horby
- Sara Modica
- Sarah Galien
- Sarah Iacopini
- Sarah Law
- Sarah McCafferty
- Sauro Luchi
- Saverio Giuseppe Parisi
- Selina Rolker
- Serafina Valente
- Serena Ludovisi
- Serghei Mangul
- Sergio Daga
- Silvia Baroni
- Silvia Cappelli
- Simona Dei
- Simona Marcantonio
- Simona Sarzi-Braga
- Simone Furini
- Slawomir Czaban
- SMelling
- Sophie Venturelli
- Stefania Mantovani
- Stefano Baratti
- Stefano Busani
- Stefano Ceri
- Stefano Rusconi
- Sten Rubertsson
- Stephan Ossowski
- Susan Walker
- Susanna Croci
- Susanna Guerrini
- SĆawomir Pancewicz
- T. Anderson
- T. Arden
- T. Baird
- T. Behan
- T. Bemand
- T. Cosier
- T. Coventry
- T. Duncan
- T. Felton
- T. Geary
- T. Hazleton
- T. Joefield
- T. Kannan
- T. Marsden
- T. Martin
- T. McHugh
- T. Newman
- T. Nortcliffe
- T. O. Jones
- T. Pogreban
- T. Rees
- T. Samakomva
- T. Smith
- T. Smith
- T. Szakmany
- T. Varghes
- T. Williams
- T. Wood
- Tammy Gilchrist
- Thorsten Brenner
- Tim Walsh
- Tiziana Bachetti
- Tomas Luther
- Tommaso Matucci
- Tony Wackett
- Torsten Feldt
- Trevor Paterson
- Tullio Trotta
- U. Poultney
- Ulrike Protzer
- Umberto Zuccon
- Urszula Korotko
- Urszula Lechowicz
- Urszula Polowianiuk
- V. Amin
- V. Anumakonda
- V. Bastion
- V. Cannons
- V. Crickmore
- V. Gopal
- V. Irvine
- V. Kasipandian
- V. Krishnamurthy
- V. Lake
- V. Linnett
- V. Martinson
- V. Nagarajan
- V. Page
- V. Parris
- V. Parris
- V. Pristopan
- V. Ratnam
- V. Riversâ
- V. Sarathy
- V. Thomas
- V. Thwaites
- V. Tuckey
- V. Turner
- V. Wagstaff
- V. Waugh
- Valentina Anemoli
- Valentina Borgo
- Valentina Perticaroli
- Verena Keitel
- Veronique Vitart
- W. Harrison
- W. Khaliq
- W. Khaliq
- W. McCormick
- W. Woodyatt
- Wadha Al-Muftah
- WES/WGS Working Group Within the HGI
- Wiktoria Izdebska
- Wilna Oosthuyzen
- X. Qiu
- Xia Shen
- Y. Baird
- Y. Choudhury
- Y. Hussain
- Y. Jackson
- Y. Thirlwall
- Yanara Marincevic-Zuniga
- Yang Wu
- Yaser Al-Sarraj
- Z. Alldis
- Z. Belagodu
- Z. Bradshaw
- Z. Coton
- Z. Daly
- Z. Farzad
- Z. Fernandez
- Z. Garland
- Z. Maqsood
- Z. Omar
- Z. Prime
- Z. Scott
- Zhijian Yang
- Publication venue
- Publication date
- 01/01/2022
- Field of study
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the presence of variants in each gene. An ensemble of LASSO logistic regression models was used to identify the most informative Boolean features with respect to the genetic bases of severity. The Boolean features selected by these logistic models were combined into an Integrated PolyGenic Score that offers a synthetic and interpretable index for describing the contribution of host genetics in COVID-19 severity, as demonstrated through testing in several independent cohorts. Selected features belong to ultra-rare, rare, low-frequency, and common variants, including those in linkage disequilibrium with known GWAS loci. Noteworthily, around one quarter of the selected genes are sex-specific. Pathway analysis of the selected genes associated with COVID-19 severity reflected the multi-organ nature of the disease. The proposed model might provide useful information for developing diagnostics and therapeutics, while also being able to guide bedside disease management. © 2021, The Author(s)
Whole-genome sequencing reveals host factors underlying critical COVID-19
- Author
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- Serra-Llovich A.
- Serrano-Heras G.
- Serrano-Ruiz A.
- Service J.
- Sesso H. D.
- Shah N.
- Shahin D.
- Shankar-Hari M.
- Shanmugasundaram P.
- Sharififard B.
- Shastri A. J.
- Shaw D.
- Shaw D. M.
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- Shaw R.
- Shelley B.
- Shelton J. F.
- Shelton S.
- Shen X.
- Shepardson S.
- Shepherd A.
- Shiel J.
- Shokkar R.
- Short A.
- Shortt J.
- Shotelersuk V.
- Shovelton C.
- Shrine N.
- Shuker K.
- Siano M.
- Sicat C.
- Siddiq A.
- Silva P.
- Sim M.
- Simms R.
- Simpson K.
- Simpson K.
- Singh J.
- Singleton J.
- Skinner D.
- Slater V.
- Slaughter M.
- Slawson N.
- Slevin K.
- Sloan B.
- Sloane G.
- Sloofman L. G.
- Smedley C.
- Smieszek S. P.
- Smith A. V.
- Smith E.
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- Smith T.
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- Smuts S.
- Smyth D.
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- Sodsai P.
- Soler P.
- Sollesta K.
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- Solomonson M.
- Soranzo N.
- Soriano A.
- Sowter J.
- Spargi G.
- Spector T. D.
- Spencer C. C. A.
- Spencer K.
- Spencer S.
- Spertilli C.
- Spivey M.
- Springle P.
- Squeo G. M.
- Sri-Chandana C.
- Srikaran S.
- Stacey A.
- Stammers K.
- Starkopf J.
- Stead R.
- Stella A.
- Stenhouse A.
- Stephens D.
- Stephenson E.
- Stephenson L.
- Stevens C.
- Stevenson L.
- Stewart R.
- Stickley J.
- Stoddard E.
- Stone S.
- Stones E.
- Stowe B.
- Strachan D.
- Stroud K.
- Stroud N.
- Stuart C.
- Stuckey A.
- Suardi C.
- Suarez J. C.
- Subramanian D.
- Subramanian G.
- Suchartlikitwong P.
- Suh N.
- Sukha A.
- Sukumaran A.
- Suliman B. A.
- Summers C.
- Summers J.
- Sumoy L.
- Sun Y. V.
- Sundar A.
- Sundaram R.
- Sutherland I.
- Sutherland S. -B.
- Suttichet T. B.
- Swain A.
- Sweeney L.
- Sweet K.
- Swets M.
- Symon L.
- Symons A.
- Szakmany T.
- Szoor-McElhinney H.
- Tabri J.
- Tacconi D.
- Tadi H. A.
- Tagliavini E.
- Tamm A.
- Tampsett R.
- Taneski F.
- Tanfoni M.
- Tang L.
- Tardif N.
- Tariq A.
- Tatham K. C.
- Tavares S.
- Tavecchia L.
- Taylor A.
- Taylor J.
- Taylor M.
- Taylor M.
- Tebbutt J.
- Templeton M.
- Tench H.
- Tenesa A.
- Tetla D.
- Texeira J.
- Thanasi M.
- Thankachen M.
- Thirlwall Y.
- Thirumaran M.
- Thomas A.
- Thomas A.
- Thomas B.
- Thomas E.
- Thomas H.
- Thomas J.
- Thomas M.
- Thomas R.
- Thomas V.
- Thomis L.
- Thompsom M.
- Thompson C.
- Thompson R.
- Thompson R. C.
- Thomson N.
- Thornton D.
- Thornton L.
- Thorpe C.
- Thrasyvoulou L.
- Thrush J.
- Thwaites V.
- Thys M.
- Tibke C.
- Tierney C.
- Tilbey S.
- Tilney E.
- Timlick E.
- Timmers P. H. J.
- Ting L.
- Tiseo G.
- Tita R.
- Tivenan H.
- Tobin M. D.
- Todd A.
- Todd L.
- Tolson M.
- Tomas A. L.
- Tommasi A.
- Tonks L.
- Torky M. S.
- Torrents D.
- Torvorapanit P.
- Tracy B.
- Trankiem A.
- Tranter H.
- Trembath R. C.
- Tridente A.
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- Trivedi B.
- Trodd D.
- Trogstad L. -I. S.
- Trotman S.
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- Trower H.
- Truman N.
- Trumper E.
- Tsao P.
- Tselios C.
- Tsinaslanidis G.
- Tsuo K.
- Tucci A.
- Tuckey V.
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- Turner P.
- Turner V.
- Turner-Bone I.
- Turney S.
- Turtle L.
- Tutton R.
- Twiss S.
- Tyl D.
- Tyler A.
- Uitterlinden A. G.
- Underwood S. J.
- Vaghi M.
- Vaida M.
- Valente S.
- Valentine J.
- Valentino F.
- van Blokland I.
- van Heel D. A.
- van Koutrik L.
- Varghese M.
- Vecchia M.
- Vedage D.
- Veerapen K.
- Venkatesh H.
- Venn L. D.
- Venturelli S.
- Vergori A.
- Verlander M.
- Verma A.
- Verma S. S.
- Vertue M.
- Verula J.
- Verzuri A.
- Vigurs C.
- Villalonga J. M.
- Vincent R.
- Vincenti A.
- Virgilio E.
- Vitart V.
- Vizcaychipi M. P.
- Vochin A.
- Voide C.
- von Frenckell C.
- von Hohenstaufen K. A.
- Vonk J. M.
- Vulesevic B.
- Vuylsteke A.
- Wackett T.
- Wadams B.
- Waddington N.
- Wagstaff V.
- Wain L. V.
- Waite A. A. C.
- Wakefield P.
- Wakinshaw F.
- Waldron J.
- Walker D.
- Walker R.
- Walker S.
- Walker S.
- Wall A.
- Walsh T.
- Walters R. K.
- Walton O.
- Wang B.
- Wang J.
- Wang X.
- Wanying Z.
- Ward G.
- Ward L.
- Ward M.
- Warden S.
- Warmerdam R.
- Warren D.
- Wassall H.
- Wasson C.
- Watkins C.
- Watson E.
- Watson G.
- Watson J.
- Watters M.
- Waugh V.
- Weaver J.
- Webster A.
- Webster D.
- Webster K.
- Wei S.
- Weiss S. T.
- Weldon C. H.
- Wells C.
- Welters I. D.
- Weston H.
- Whileman A.
- Whitbread J.
- White D.
- White I.
- White K.
- White M.
- White N.
- White N.
- Whiteley S.
- Whiteside J.
- Whittle H.
- Whitton C.
- Whyte C.
- Wicks S. J.
- Wilby E.
- Wilcox L.
- Wilcox R.
- Wild H.
- Wild L.
- Wiles M.
- Wilkins J.
- Wilkinson A.
- Wilkinson B.
- Willer C.
- Williams A.
- Williams A.
- Williams A.
- Williams A. T.
- Williams D.
- Williams E.
- Williams F.
- Williams G.
- Williams H.
- Williams K.
- Williams M.
- Williams P.
- Williams S.
- Williams T.
- Willis C.
- Willis H.
- Wills M.
- Willson J.
- Wilson A.
- Wilson D. J.
- Wilson J.
- Wilson J. F.
- Winnard S.
- Winter-Goodwin B.
- Wolf-Roberts R.
- Wolford B.
- Wong J.
- Wood D.
- Wood H. -L.
- Wood S.
- Wood T.
- Woodford C.
- Woodruff M.
- Woods L.
- Woodyatt W.
- Woolley A. E.
- Worner R.
- Worsley L.
- Wray G.
- Wren L.
- Wright D.
- Wright J.
- Wright M.
- Wrobel N.
- Wu Y.
- Wulandari R.
- Wyllie D. H.
- Wynter I.
- Xavier K.
- Xue X.
- Yadav A.
- Yang J.
- Yassen A. M.
- Yates B.
- Ye C.
- Yun N.
- Zainy T.
- Zak A.
- Zaki A.
- Zamikula J.
- Zanella I.
- Zborowski A. C.
- Zeberg H.
- Zechner M.
- Zguro K.
- Zhang M.
- Zhao J. H.
- Zheng C.
- Zhou W.
- Zitter L.
- Zlatopolsky M.
- Zollner S.
- Zongo O.
- Zucchi P.
- Zyndorf M.
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2â4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genesâincluding reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)âin critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease
A blood atlas of COVID-19 defines hallmarks of disease severity and specificity.
- Author
- Ahern David J
- Ai Zhichao
- Ainsworth Mark
- Allan Chris
- Allcock Alice
- Angus Brian
- Ansari M Azim
- Arancibia-Carcamo Carolina V
- Aschenbrenner Dominik
- Attar Moustafa
- Baillie J Kenneth
- Barnes Eleanor
- Bashford-Rogers Rachael
- Bashyal Archana
- Beer Sally
- Berridge Georgina
- Beveridge Amy
- Bibi Sagida
- Bicanic Tihana
- Blackwell Luke
- Bowness Paul
- Brent Andrew
- Brown Andrew
- Broxholme John
- Buck David
- Burnham Katie L
- Byrne Helen
- Camara Susana
- Charles Philip
- Chen Wentao
- Chen Yi-Ling
- Chong Amanda
- Clutterbuck Elizabeth A
- Coles Mark
- Conlon Christopher P
- Cornall Richard
- Cribbs Adam P
- Curion Fabiola
- Davenport Emma E
- Davidson Neil
- Davis Simon
- Delgado Alberto Santos
- Dendrou Calliope A
- Dequaire Julie
- Dib Lea
- Docker James
- Dold Christina
- Dong Tao
- Downes Damien
- Drakesmith Hal
- Dunachie Susanna J
- Duncan David A
- Eijsbouts Chris
- Esnouf Robert
- Espinosa Alexis
- Etherington Rachel
- Fairfax Benjamin
- Fairhead Rory
- Fang Hai
- Fassih Shayan
- Felle Sally
- Ferreira Ivan Candido
- Ferreira Ricardo
- Fischer Roman
- Foord Thomas
- Forrow Aden
- Frater John
- Fries Anastasia
- Garner Lucy C
- Geeves Clementine
- Georgiou Dominique
- Godfrey Leila
- Golubchik Tanya
- Green Angie
- Harper Hong
- Harrington Heather A
- Heilig Raphael
- Hester Svenja
- Hill Jennifer
- Hinds Charles
- Hird Clare
- Ho Ling-Pei
- Hoekzema Renee
- Hollis Benjamin
- Hughes Jim
- Hutton Paula
- Jackson-Wood Matthew A
- Jainarayanan Ashwin
- James-Bott Anna
- Jansen Kathrin
- Jeffery Katie
- Jones Elizabeth
- Jostins Luke
- Karali Christina Simoglou
- Kerr Georgina
- Kim David
- Klenerman Paul
- Knight Julian C
- Kumar Vinod
- Kurupati Prathiba
- Kwok Andrew
- Lee Angela
- Linder Aline
- Lockett Teresa
- Lonie Lorne
- Lopopolo Maria
- Lukoseviciute Martyna
- Luo Jian
- Marinou Spyridoula
- Marsden Brian
- Martinez Jose
- Matthews Philippa C
- Mazurczyk Michalina
- McGowan Simon
- McKechnie Stuart
- Mead Adam
- Mendoza Maria Fernandez
- Mentzer Alexander J
- Mi Yuxin
- Monaco Claudia
- Montadon Ruddy
- Napolitani Giorgio
- Nassiri Isar
- Novak Alex
- O'Brien Darragh P
- O'Connor Daniel
- O'Donnell Denise
- Ogg Graham
- Overend Lauren
- Park Inhye
- Pavord Ian
- Peng Yanchun
- Penkava Frank
- Peres Raphael Sanches
- Perez Elena
- Pinho Mariana Pereira
- Pollard Andrew J
- Powrie Fiona
- Psaila Bethan
- Quan T Phuong
- Repapi Emmanouela
- Revale Santiago
- Rich-Griffin Charlotte
- Richard Jean-Baptiste
- Ritter Thomas
- Rollier Christine S
- Rowland Matthew
- Ruehle Fabian
- Salio Mariolina
- Sanchez Veronica Gallardo
- Sansom Stephen Nicholas
- Sauka-Spengler Tatjana
- Schwessinger Ron
- Scozzafava Giuseppe
- Screaton Gavin
- Seigal Anna
- Semple Malcolm G
- Sergeant Martin
- Sharma Piyush Kumar
- Silva-Reyes Laura
- Sims David
- Skelly Donal
- Slawinski Hubert
- Sobrinodiaz Alberto
- Sousos Nikolaos
- Stafford Lizzie
- Stockdale Lisa
- Strickland Marie
- Sumray Otto
- Sun Bo
- Taylor Adan
- Taylor Chelsea
- Taylor Stephen
- Thongjuea Supat
- Thraves Hannah
- Todd John A
- Tomic Adriana
- Tong Orion
- Trebes Amy
- Trzupek Dominik
- Tucci Felicia Anna
- Turtle Lance
- Udalova Irina
- Uhlig Holm
- van Grinsven Erinke
- Vazquez Maria Gomez
- Vendrell Iolanda
- Verheul Marije
- Voda Alexandru
- Wang Dapeng
- Wang Guanlin
- Wang Lihui
- Watkinson Peter
- Watson Robert
- Weinberger Michael
- Whalley Justin
- Witty Lorna
- Wray Katherine
- Xue Luzheng
- Yeung Hing Yuen
- Yin Zixi
- Young Rebecca K
- Youngs Jonathan
- Zhang Ping
- Zurke Yasemin-Xiomara
- Publication venue
- Elsevier
- Publication date
- 01/01/2021
- Field of study
Treatment of severe COVID-19 is currently limited by clinical heterogeneity and incomplete description of specific immune biomarkers. We present here a comprehensive multi-omic blood atlas for patients with varying COVID-19 severity in an integrated comparison with influenza and sepsis patients versus healthy volunteers. We identify immune signatures and correlates of host response. Hallmarks of disease severity involved cells, their inflammatory mediators and networks, including progenitor cells and specific myeloid and lymphocyte subsets, features of the immune repertoire, acute phase response, metabolism, and coagulation. Persisting immune activation involving AP-1/p38MAPK was a specific feature of COVID-19. The plasma proteome enabled sub-phenotyping into patient clusters, predictive of severity and outcome. Systems-based integrative analyses including tensor and matrix decomposition of all modalities revealed feature groupings linked with severity and specificity compared to influenza and sepsis. Our approach and blood atlas will support future drug development, clinical trial design, and personalized medicine approaches for COVID-19
Social Bonding and Nurture Kinship: Compatibility between Cultural and Biological Approaches
- Author
- A Cockburn
- A Fuentes
- A Grafen
- A Grafen
- A I Richards
- A L Clarke
- A L Kroeber
- A Mathias
- A Paul
- A Pusey
- A R Blaustein
- A R Blaustein
- A R Radcliffe-Brown
- A Romeyer
- A Romeyer
- A Schrauwers
- A T C Feistner
- A Vilaca
- A Widdig
- A Widdig
- Adam Kuper
- Adrienne L Zihlman
- Agustin Fuentes
- Alan Grafen
- Andreas Paul
- Andrew Strathern
- Anna Meigs
- Anne E Pusey
- B B Smuts
- B Chapais
- B Gutmann
- B Hewlett
- B Malinowski
- B Waldman
- Barbara Bodenhorn
- Barbera Fruth
- Bertha Phillpotts
- Brenda Geiger
- Bronislaw Malinowski
- Bryan S Turner
- C A Carreno
- C D Batson
- C Geertz
- C L Hull
- C P Doncaster
- C R Gabor
- C R Ruiz-Miranda
- C Zahn-Waxler
- Carol R Ember
- Charles Darwin
- Charles J Lumsden
- Charles Stafford
- Clutton Brock
- Clutton Brock
- Curt D Busse
- D Barbosa
- D C Queller
- D Haig
- D Maybury-Lewis
- D O Ribble
- D S Wilson
- D Schneider
- D&apos
- Dan Rubenstein
- David J Gubernick
- David Schneider
- David Schneider
- David W Macdonald
- Diana Davis
- Donald Symons
- E B Hanggi
- E B Tylor
- E D Lowe
- E E Evans-Pritchard
- E J Pader
- E K Bollinger
- E Kapsalis
- E L Charnov
- E M Daly
- E M Erhart
- E Paradis
- E S Hartland
- E Sober
- Edward Wilson
- Edward Z Tronick
- Eibl-Eibesfeld
- Ernest Crawley
- F D Tai
- F Marlowe
- Friedrich Engels
- G H Orians
- G Heth
- G J Broude
- G J Gamboa
- G Macgregor
- Gary Witherspoon
- Georg Simmel
- George C Price
- George C Williams
- George Murdock
- Gottfried Hohmann
- H Barry
- H F Harlow
- H Hernandez
- H O Sigling
- H R Schaffer
- Hans Temrin
- Harold W Scheffler
- Harold W Scheffler
- Helen Lambert
- Henrietta L Moore
- Henry S Maine
- I S Bernstein
- I S Bernstein
- Isaac Schapera
- Ivan A Brady
- J A Barnes
- J A Byers
- J A Kurland
- J A Kurland
- J Altmann
- J B S Haldane
- J B S Haldane
- J B Silk
- J B Silk
- J B Watson
- J Bowlby
- J Carsten
- J Carsten
- J D Korchmaros
- J F Hare
- J F Hare
- J H Crook
- J M J Travis
- J M Stookey
- J Moore
- J O Wolff
- J Pitt-Rivers
- J R Kurland
- J Topal
- J W Bradbury
- J W Lawson
- J Walters
- J Yamagiwa
- Jack Goody
- James J Mckenna
- Jane Collier
- Janet Carsten
- Jay Belsky
- Joanna Overing
- John Bowlby
- John Hartung
- John Terrell
- John Tooby
- Julie C Rothbard
- K A Houpt
- K B Carnelley
- K Hawkes
- K Hawkes
- K Johst
- K Summers
- Karyl B Swartz
- Kathey-Lee Galvin
- Kathleen Gough
- L A Hirschfeld
- L A Isbell
- L F Keller
- L H Morgan
- L L Langness
- L Rival
- L Stone
- L X Sun
- Ladislav Holy
- Lancaster
- Laura L Betzig
- Laura Zimmer-Tamakoshi
- Lee Guemple
- Lewis Morgan
- Linda M Fedigan
- M A Mcpeek
- M Ainsworth
- M Bekoff
- M Boots
- M D Ainsworth
- M Daly
- M E Hauber
- M Easterbrooks
- M Ember
- M Flinn
- M Freedman
- M Heino
- M I D Janzen
- M Jackel
- M L Johnson
- M Mead
- M Pagel
- M Sahlins
- Mac Marshall
- Marcel Mauss
- Margaret Mead
- Marilyn Strathern
- Mark Nuttall
- Mark R D Flinn
- Mark Ridley
- Marshall Sahlins
- Mary Bouquet
- Mary Weismantel
- Matin Daly
- Maurice Bloch
- Maximilian Piers Holland
- Maynard Smith
- Maynard Smith
- Michael Carrithers
- Michael E Lamb
- Michael Young
- Monica Janowski
- N Nicolson
- N Osawa
- N Perrin
- Napoleon A Chagnon
- Nichole L Sault
- Nikko Tinbergen
- P Crnokrak
- P J Jarman
- P J Richardson
- P Jay
- P M Kappeler
- P S Kitcher
- P Valsecchi
- P W Sherman
- Pasternak
- Paul W Sherman
- Penelope J Greene
- Peter G Hepper
- Peter Gow
- Peter P Schweitzer
- Philip Thomas
- Phyllis Dolhinow
- R A Palombit
- R Blatrix
- R C Lacy
- R C Lacy
- R D Alexander
- R E Michod
- R F Guerra
- R Fox
- R H Macarthur
- R H Porter
- R H Porter
- R J Stuart
- R Thornhill
- R W Firth
- Raymond Firth
- Richard D Alexander
- Richard Dawkins
- Richard Feinberg
- Richard W Wrangham
- Richard Wrangham
- Roberson Smith
- Robert H Lowie
- Robert L Trivers
- Robert Mckinley
- Robert Parkin
- Robert S Weiss
- Robert Storrie
- Rodney Needham
- Ronald A Fisher
- Rufus A Johnstone
- S A Altmann
- S B Hrdy
- S B Hrdy
- S Belichon
- S C Alberts
- S C Alberts
- S C Stearns
- S C Walls
- S C Walls
- S D Preston
- S D Viegas
- S Emlen
- S G Gonzalez
- S J Gould
- S Wright
- Sally Slocum
- Salvatore Cucchiari
- Sandy J Andelman
- Sarah Gouzoules
- Sewall Wright
- Sherrie L Lyons
- Sherwood Washburn
- Stella Marsden
- Steve Pinker
- Steven A Frank
- Steven J C Gaulin
- Steven M Parish
- Susan P Montague
- Sylvia Yanagisako
- T Clutton-Brock
- T Nishida
- Thomas Huxley
- Tim Ingold
- Todd R Disotell
- U Motro
- U Reichard
- V B Wigglesworth
- V Mekoshrosenbaum
- Van Gennep
- W C H Green
- W C Hartwig
- W C Mcgrew
- W D Hamilton
- W G Holmes
- W G Holmes
- W G Holmes
- Ward H Goodenough
- Warren G Holmes
- William D Hamilton
- William D Hamilton
- William H Berman
- William Irons
- X Lambin
- Y Sugiyama
- Yehudi A Cohen
- Z T Halpin
- Z Tang-Martinez
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2004
- Field of study
EURECâŽA
- Author
- A. A. Ubele
- A. A. Wing
- A. Bailey
- A. Baron
- A. Behrendt
- A. Bendinger
- A. Blyth
- A. Brewer
- A. Daley
- A. Ehrlich
- A. Emmanouilidis
- A. Fix
- A. Gadian
- A. Giez
- A. Hausold
- A. Ibanez-Landeta
- A. K. Naumann
- A. K. Naumann
- A. Kellman
- A. Kurz
- A. L. Albright
- A. Laing
- A. Minikin
- A. N. Meroni
- A. Napoli
- A. Neuberger
- A. P. Siebesma
- A. Plueddemann
- A. Reyes
- A. Schwarzenboeck
- A. Sealy
- A. Smirnov
- A. T. Kidane
- A. Walther
- A. Wiltshire
- B. BrĂŒgmann
- B. Fildier
- B. Holanda
- B. Mayer
- B. Spooner
- B. Stevens
- B. Webber
- C. Acquistapace
- C. B. Rocha
- C. C. Stephan
- C. Cornet
- C. Fairall
- C. Flamant
- C. Gaston
- C. Gentemann
- C. Gourbeyre
- C. Herbert
- C. J. Senff
- C. J. Senff
- C. Laplace
- C. Le Bihan
- C. Luneau
- C. Mazel
- C. Muller
- C. Noisel
- C. Peck
- C. Pöhlker
- C. Rollo
- C. Zhang
- D. Baranowski
- D. Bourras
- D. de Graaf
- D. Farrell
- D. Henze
- D. J. Parker
- D. Klocke
- D. Lange
- D. Lenschow
- D. Noone
- D. Zhang
- D. Zhang
- E. Blades
- E. Bodenschatz
- E. Burke
- E. Marinou
- E. Marinou
- E. Quiñones Meléndez
- E. Siddle
- E. Tetoni
- E. Thompson
- E. Wright
- F. Aemisegger
- F. Ament
- F. Ament
- F. Batier
- F. Beucher
- F. Couvreux
- F. Ewald
- F. Jansen
- F. Julien
- F. Nordsiek
- F. SpÀth
- F. Ziemen
- G. Bagheri
- G. Cato Jr.
- G. de Boer
- G. de Boer
- G. E. de Groot
- G. Faure
- G. Feingold
- G. George
- G. Harris
- G. Lavik
- G. Lloyd
- G. M. Damerell
- G. Manta
- G. Möller
- G. R. Foltz
- G. Reverdin
- G. Roberts
- G. Roberts
- H. Asmath
- H. Bellenger
- H. Branger
- H. Coe
- H. Deneke
- H. Kalesse
- H. Konow
- H. Royer
- H. Schulz
- I. Furtuna
- I. Gouirand
- I. Lange
- I. Musat
- I. Sandu
- I. Schirmacher
- I. Serikov
- J. A. Charles
- J. C. McWilliams
- J. Delanoë
- J. Galewsky
- J. Gollop
- J. GĂŒttler
- J. Intrieri
- J. Karstensen
- J. Kazil
- J. Kazil
- J. Kretzschmar
- J. L. Nowak
- J. Radtke
- J. Radtke
- J. Reimann
- J. Ribbe
- J. Röttenbacher
- J. Schmidt
- J. Thomson
- J. Totems
- J. Vial
- J. von Arx
- J. Wiskandt
- J.-C. Canonici
- J.-C. Etienne
- J.-P. Desbios
- K. Baier
- K. Bower
- K. C. Helfer
- K. Drushka
- K. Emanuel
- K. Hall
- K. J. Heywood
- K. Ramage
- K. Reus
- K. Wolf
- K.-A. Caesar
- L. A. Kremper
- L. Alves
- L. Denby
- L. Ferrero
- L. Forster
- L. Hirsch
- L. Nuijens
- L. Olivier
- L. Oswald
- L. Pologne
- L. Renault
- L. Renault
- L. Saffin
- L. Tomassini
- L. Touzé-Peiffer
- L. Villiger
- L. Worbes
- M. Brennek
- M. DĂŒtsch
- M. DĂŒtsch
- M. Forde
- M. Gallagher
- M. Gutleben
- M. Hagen
- M. Jacob
- M. K. Stolla
- M. Klingebiel
- M. Körner
- M. Labaste
- M. Leandro
- M. Lena
- M. Lothon
- M. Mayers-Als
- M. Mech
- M. Mehlmann
- M. Philippi
- M. Posyniak
- M. Prange
- M. Pöhlker
- M. Ringel
- M. Ritschel
- M. Schröder
- M. SchÀfer
- M. T. Chilinski
- M. Wendisch
- M. Wirth
- M. Zöger
- N. Alexander
- N. Geyskens
- N. Lefevre
- N. Losi
- N. Marsden
- N. Maury
- N. Rochetin
- O. Bock
- O. KrĂŒger
- O. Lovell
- O. Schlenczek
- P. A. Barrett
- P. Blossey
- P. Bosser
- P. Bouruet-Aubertot
- P. Branellec
- P. Chazette
- P. Chuang
- P. Coutris
- P. Gallimore
- P. J. Flatau
- P. K. Quinn
- P. L'HĂ©garet
- P. LandschĂŒtzer
- P. Makuch
- P. Minnett
- P. Sadoulet
- P. Sullivan
- P. Zuidema
- P.-E. Brilouet
- Q. Li
- R. Burton
- R. Calmer
- R. Chewitt-Lucas
- R. Grosz
- R. Laxenaire
- R. Person
- R. Person
- R. Pincus
- R. Pincus
- R. Vogel
- S. A. Buehler
- S. Arixi
- S. Barrau
- S. Bigorre
- S. Bony
- S. Böing
- S. Clarke
- S. Crewell
- S. Donner
- S. Dörner
- S. Etienne-Leblanc
- S. Gross
- S. Iyer
- S. Kinne
- S. Los
- S. Malinowski
- S. Masson
- S. P. de Szoeke
- S. Sandiford
- S. Schnitt
- S. Shohan
- S. Speich
- S. Tarot
- S. Whitehall
- S. Young
- T. Choularton
- T. Cronin
- T. Dauhut
- T. Kölling
- T. Kölling
- T. Lachlan-Cope
- T. Lang
- T. Lang
- T. Mieslinger
- T. Mieslinger
- T. Wagner
- T. Zinner
- U. Kirchner
- U. Pöschl
- V. Douet
- V. Pörtge
- V. Schemann
- V. Wulfmeyer
- W. Kumala
- W. McGeary
- W. McGeary
- W. Mohr
- W. SzkĂłĆka
- X. Carton
- Y. Chen
- Y. Cuypers
- Y. Morfa Avalos
- Z. Cui
- Publication venue
- 'Copernicus GmbH'
- Publication date
- 10/11/2020
- Field of study
The science guiding the EURECâŽA campaign and its measurements is presented. EURECâŽA comprised roughly 5 weeks of measurements in the downstream winter trades of the North Atlantic â eastward and southeastward of Barbados. Through its ability to characterize processes operating across a wide range of scales, EURECâŽA marked a turning point in our ability to observationally study factors influencing clouds in the trades, how they will respond to warming, and their link to other components of the earth system, such as upper-ocean processes or the life cycle of particulate matter. This characterization was made possible by thousands (2500) of sondes distributed to measure circulations on meso- (200âkm) and larger (500âkm) scales, roughly 400âh of flight time by four heavily instrumented research aircraft; four global-class research vessels; an advanced ground-based cloud observatory; scores of autonomous observing platforms operating in the upper ocean (nearly 10â000 profiles), lower atmosphere (continuous profiling), and along the airâsea interface; a network of water stable isotopologue measurements; targeted tasking of satellite remote sensing; and modeling with a new generation of weather and climate models. In addition to providing an outline of the novel measurements and their composition into a unified and coordinated campaign, the six distinct scientific facets that EURECâŽA explored â from North Brazil Current rings to turbulence-induced clustering of cloud droplets and its influence on warm-rain formation â are presented along with an overview of EURECâŽA's outreach activities, environmental impact, and guidelines for scientific practice. Track data for all platforms are standardized and accessible at https://doi.org/10.25326/165 (Stevens, 2021), and a film documenting the campaign is provided as a video supplement
EURECâŽA
- Author
- A. A. Ubele
- A. A. Wing
- A. Bailey
- A. Baron
- A. Behrendt
- A. Bendinger
- A. Blyth
- A. Brewer
- A. Daley
- A. Ehrlich
- A. Emmanouilidis
- A. Fix
- A. Gadian
- A. Giez
- A. Hausold
- A. Ibanez-Landeta
- A. K. Naumann
- A. K. Naumann
- A. Kellman
- A. Kurz
- A. L. Albright
- A. Laing
- A. Minikin
- A. N. Meroni
- A. Napoli
- A. Neuberger
- A. P. Siebesma
- A. Plueddemann
- A. Reyes
- A. Schwarzenboeck
- A. Sealy
- A. Smirnov
- A. T. Kidane
- A. Walther
- A. Wiltshire
- B. BrĂŒgmann
- B. Fildier
- B. Holanda
- B. Mayer
- B. Spooner
- B. Stevens
- B. Webber
- C. Acquistapace
- C. B. Rocha
- C. C. Stephan
- C. Cornet
- C. Fairall
- C. Flamant
- C. Gaston
- C. Gentemann
- C. Gourbeyre
- C. Herbert
- C. J. Senff
- C. J. Senff
- C. Laplace
- C. Le Bihan
- C. Luneau
- C. Mazel
- C. Muller
- C. Noisel
- C. Peck
- C. Pöhlker
- C. Rollo
- C. Zhang
- D. Baranowski
- D. Bourras
- D. de Graaf
- D. Farrell
- D. Henze
- D. J. Parker
- D. Klocke
- D. Lange
- D. Lenschow
- D. Noone
- D. Zhang
- D. Zhang
- E. Blades
- E. Bodenschatz
- E. Burke
- E. Marinou
- E. Marinou
- E. Quiñones Meléndez
- E. Siddle
- E. Tetoni
- E. Thompson
- E. Wright
- F. Aemisegger
- F. Ament
- F. Ament
- F. Batier
- F. Beucher
- F. Couvreux
- F. Ewald
- F. Jansen
- F. Julien
- F. Nordsiek
- F. SpÀth
- F. Ziemen
- G. Bagheri
- G. Cato Jr.
- G. de Boer
- G. de Boer
- G. E. de Groot
- G. Faure
- G. Feingold
- G. George
- G. Harris
- G. Lavik
- G. Lloyd
- G. M. Damerell
- G. Manta
- G. Möller
- G. R. Foltz
- G. Reverdin
- G. Roberts
- G. Roberts
- H. Asmath
- H. Bellenger
- H. Branger
- H. Coe
- H. Deneke
- H. Kalesse
- H. Konow
- H. Royer
- H. Schulz
- I. Furtuna
- I. Gouirand
- I. Lange
- I. Musat
- I. Sandu
- I. Schirmacher
- I. Serikov
- J. A. Charles
- J. C. McWilliams
- J. Delanoë
- J. Galewsky
- J. Gollop
- J. GĂŒttler
- J. Intrieri
- J. Karstensen
- J. Kazil
- J. Kazil
- J. Kretzschmar
- J. L. Nowak
- J. Radtke
- J. Radtke
- J. Reimann
- J. Ribbe
- J. Röttenbacher
- J. Schmidt
- J. Thomson
- J. Totems
- J. Vial
- J. von Arx
- J. Wiskandt
- J.-C. Canonici
- J.-C. Etienne
- J.-P. Desbios
- K. Baier
- K. Bower
- K. C. Helfer
- K. Drushka
- K. Emanuel
- K. Hall
- K. J. Heywood
- K. Ramage
- K. Reus
- K. Wolf
- K.-A. Caesar
- L. A. Kremper
- L. Alves
- L. Denby
- L. Ferrero
- L. Forster
- L. Hirsch
- L. Nuijens
- L. Olivier
- L. Oswald
- L. Pologne
- L. Renault
- L. Renault
- L. Saffin
- L. Tomassini
- L. Touzé-Peiffer
- L. Villiger
- L. Worbes
- M. Brennek
- M. DĂŒtsch
- M. DĂŒtsch
- M. Forde
- M. Gallagher
- M. Gutleben
- M. Hagen
- M. Jacob
- M. K. Stolla
- M. Klingebiel
- M. Körner
- M. Labaste
- M. Leandro
- M. Lena
- M. Lothon
- M. Mayers-Als
- M. Mech
- M. Mehlmann
- M. Philippi
- M. Posyniak
- M. Prange
- M. Pöhlker
- M. Ringel
- M. Ritschel
- M. Schröder
- M. SchÀfer
- M. T. Chilinski
- M. Wendisch
- M. Wirth
- M. Zöger
- N. Alexander
- N. Geyskens
- N. Lefevre
- N. Losi
- N. Marsden
- N. Maury
- N. Rochetin
- O. Bock
- O. KrĂŒger
- O. Lovell
- O. Schlenczek
- P. A. Barrett
- P. Blossey
- P. Bosser
- P. Bouruet-Aubertot
- P. Branellec
- P. Chazette
- P. Chuang
- P. Coutris
- P. Gallimore
- P. J. Flatau
- P. K. Quinn
- P. L'HĂ©garet
- P. LandschĂŒtzer
- P. Makuch
- P. Minnett
- P. Sadoulet
- P. Sullivan
- P. Zuidema
- P.-E. Brilouet
- Q. Li
- R. Burton
- R. Calmer
- R. Chewitt-Lucas
- R. Grosz
- R. Laxenaire
- R. Person
- R. Person
- R. Pincus
- R. Pincus
- R. Vogel
- S. A. Buehler
- S. Arixi
- S. Barrau
- S. Bigorre
- S. Bony
- S. Böing
- S. Clarke
- S. Crewell
- S. Donner
- S. Dörner
- S. Etienne-Leblanc
- S. Gross
- S. Iyer
- S. Kinne
- S. Los
- S. Malinowski
- S. Masson
- S. P. de Szoeke
- S. Sandiford
- S. Schnitt
- S. Shohan
- S. Speich
- S. Tarot
- S. Whitehall
- S. Young
- T. Choularton
- T. Cronin
- T. Dauhut
- T. Kölling
- T. Kölling
- T. Lachlan-Cope
- T. Lang
- T. Lang
- T. Mieslinger
- T. Mieslinger
- T. Wagner
- T. Zinner
- U. Kirchner
- U. Pöschl
- V. Douet
- V. Pörtge
- V. Schemann
- V. Wulfmeyer
- W. Kumala
- W. McGeary
- W. McGeary
- W. Mohr
- W. SzkĂłĆka
- X. Carton
- Y. Chen
- Y. Cuypers
- Y. Morfa Avalos
- Z. Cui
- Publication venue
- 'Copernicus GmbH'
- Publication date
- 10/11/2020
- Field of study
The science guiding the EURECâŽA campaign and its measurements is presented. EURECâŽA comprised roughly 5 weeks of measurements in the downstream winter trades of the North Atlantic â eastward and southeastward of Barbados. Through its ability to characterize processes operating across a wide range of scales, EURECâŽA marked a turning point in our ability to observationally study factors influencing clouds in the trades, how they will respond to warming, and their link to other components of the earth system, such as upper-ocean processes or the life cycle of particulate matter. This characterization was made possible by thousands (2500) of sondes distributed to measure circulations on meso- (200âkm) and larger (500âkm) scales, roughly 400âh of flight time by four heavily instrumented research aircraft; four global-class research vessels; an advanced ground-based cloud observatory; scores of autonomous observing platforms operating in the upper ocean (nearly 10â000 profiles), lower atmosphere (continuous profiling), and along the airâsea interface; a network of water stable isotopologue measurements; targeted tasking of satellite remote sensing; and modeling with a new generation of weather and climate models. In addition to providing an outline of the novel measurements and their composition into a unified and coordinated campaign, the six distinct scientific facets that EURECâŽA explored â from North Brazil Current rings to turbulence-induced clustering of cloud droplets and its influence on warm-rain formation â are presented along with an overview of EURECâŽA's outreach activities, environmental impact, and guidelines for scientific practice. Track data for all platforms are standardized and accessible at https://doi.org/10.25326/165 (Stevens, 2021), and a film documenting the campaign is provided as a video supplement
- âŠ