Lightning talks of EduHPC 2022

The lightning talks at EduHPC provide an opportunity to share early results and insights on parallel and distributed computing (PDC) education and training efforts. The four lightning talks at EduHPC 2022 cover a range of topics in broadening PDC education: (i) curriculum development efforts for the European Masters in HPC program, (ii) bootcamps for CI professionals who support the running of AI workloads on HPC systems, (iii) a GPU programming course following the Carpentries model and (iv) peer-review assignments to help students write efficient parallel algorithms within sustainable software libraries.Peer ReviewedArticle signat per 26 autors/es: Apan Qasem 1, Hartwig Anzt 2,3, Eduard Ayguade 4, Katharine Cahill 5, Ramon Canal 4, Jany Chan 6, Eric Fosler-Lussier 6, Fritz Göbel 2, Arpan Jain 6, Marcel Koch 2, Mateusz Kuzak 7, Josep Llosa 4, Raghu Machiraju 6, Xavier Martorell 4, Pratik Nayak 2, Shameema Oottikkal 5, Marcin Ostasz 8, Dhabaleswar K. Panda 6, Dirk Pleiter 9, Rajiv Ramnath 6, Maria-Ribera Sancho 4, Alessio Sclocco 7, Aamir Shafi 6, Hanno Spreeuw 7, Hari Subramoni 6, Karen Tomko 7 / 1 Department of Computer Science, Texas State University, USA; 2 Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany; 3 University of Tennessee (UTK), Knoxville, USA; 4 Barcelona Supercomputing Center and Universitat Politècnica de Catalunya, Spain; 5 Ohio Supercomputer Center, USA; 6 College of Engineering, The Ohio State University, USA; 7 Netherlands eScience Center, The Netherlands; 8 ETP4HPC, The Netherlands; 9 PDC Center for High Performance Computing, KTH Royal Institute of Technology, SwedenPostprint (author's final draft

NEIL3 Repairs Telomere Damage during S Phase to Secure Chromosome Segregation at Mitosis

Oxidative damage to telomere DNA compromises telomere integrity. We recently reported that the DNA glycosylase NEIL3 preferentially repairs oxidative lesions in telomere sequences in vitro. Here, we show that loss of NEIL3 causes anaphase DNA bridging because of telomere dysfunction. NEIL3 expression increases during S phase and reaches maximal levels in late S/G2. NEIL3 co-localizes with TRF2 and associates with telomeres during S phase, and this association increases upon oxidative stress. Mechanistic studies reveal that NEIL3 binds to single-stranded DNA via its intrinsically disordered C terminus in a telomere-sequence-independent manner. Moreover, NEIL3 is recruited to telomeres through its interaction with TRF1, and this interaction enhances the enzymatic activity of purified NEIL3. Finally, we show that NEIL3 interacts with AP Endonuclease 1 (APE1) and the long-patch base excision repair proteins PCNA and FEN1. Taken together, we propose that NEIL3 protects genome stability through targeted repair of oxidative damage in telomeres during S/G2 phase

Relational Capability: A Multidimensional Approach

This paper explores some of the dimensions related to poverty and exclusion, by defining a Relational Capability Index (RCI) which focuses on the quality of relationships among people and on their level of relational empowerment. This index is rooted in a relational anthropology; it insists on the quality of the social fabric and of interpersonal relations as a key aspect of human development. As a multidimensional index, the RCI includes integration into networks, private relations and civic commitments. We provide an axiomatization of a family of multidimensional indexes. This axiomatic viewpoint fills the gap between theories of justice and poverty measurements. By means of illustration, we apply three different versions of the RCI, which are elements of this family, to the measurement of the impact of oil companies on local communities in the Niger Delta (Nigeria) and to national surveys (Afrobarometer)