232 research outputs found
Use of fall risk increasing drugs in residents of retirement villages: a pilot study of long term care and retirement home residents in Ontario, Canada
- Author
- A Gruneir
- A Kragh
- A Lukas
- A Spinewine
- AG Zermansky
- AG Zermansky
- AJ Campbell
- AJ Campbell
- Andrea Wong
- AR Huang
- C Becker
- C Rojas-Fernandez
- Carlos Rojas-Fernandez
- CH Rojas-Fernandez
- CH Rojas-Fernandez
- CH Rojas-Fernandez
- CI Neutel
- CS Sterke
- D Prudham
- ER Hajjar
- Farzan Dadfar
- J Whitney
- JT Hanlon
- KD Hill
- LM Allan
- ME Tinetti
- ME Tinetti
- ME Tinetti
- ME Tinetti
- N Boyle
- N Velde van der
- RD Clark
- RM Clements
- SE Lamb
- SI Zimmerman
- SR Lord
- Susan G. Brown
- SW Pit
- V Scott
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Structural insight into SUMO chain recognition and manipulation by the ubiquitin ligase RNF4
- Author
- A Hershko
- A Plechanovova
- A Plechanovova
- A Rojas-Fernandez
- AM Weissman
- AT Brunger
- AT Namanja
- CC Chang
- CH Cheng
- CM Hecker
- CM Pickart
- CW Liew
- D Reverter
- E Escobar-Cabrera
- ES Johnson
- F Ikeda
- FM Lin
- GNB Yip
- H Sun
- HD Ulrich
- HY Sun
- I Matic
- J Marchant
- J Prudden
- J Song
- J Song
- J Xia
- JD Schnell
- JH Hurley
- JL Battiste
- JS Thrower
- K Keusekotten
- L Deng
- M Ottiger
- M Zweckstetter
- MH Tatham
- MH Tatham
- MJ Eddins
- MJ Eddins
- MR Hansen
- MS Rodriguez
- N Sekiyama
- N Zhang
- O Kerscher
- O Kerscher
- Q Wang
- R Bruderer
- R Lescasse
- R Mahajan
- R Varadan
- RT Hay
- S-R Tzeng
- SC Panchal
- W Rieping
- W-C Huang
- XD Zhang
- Y Shen
- Y Xie
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/06/2014
- Field of study
The small ubiquitin-like modifier (SUMO) can form polymeric chains that are important signals in cellular processes such as meiosis, genome maintenance and stress response. The SUMO-targeted ubiquitin ligase RNF4 engages with SUMO chains on linked substrates and catalyses their ubiquitination, which targets substrates for proteasomal degradation. Here we use a segmental labelling approach combined with solution nuclear magnetic resonance (NMR) spectroscopy and biochemical characterization to reveal how RNF4 manipulates the conformation of the SUMO chain, thereby facilitating optimal delivery of the distal SUMO domain for ubiquitin transfer
A phase IV, two-armed, randomized, cross-over study comparing compliance with once-a-month administration of vitamin D3 to compliance with daily administration of a fixed-dose combination of vitamin D3 and calcium during two 6-month periods
- Author
- A Diez
- A Zittermann
- BW Hollis
- C Castelo-Branco
- C Trevisan
- CH Rojas-Fernandez
- D Challoumas
- E. Cavalier
- HF Saadi
- J.-Y. Reginster
- JA Kanis
- JP Bonjour
- JR Lewis
- JY Reginster
- KM Sanders
- L Wang
- M. Coffiner
- MF Holick
- MJ Bolland
- MJ Bolland
- N. Dardenne
- O Bruyere
- O Bruyere
- O. Bruyère
- R Rizzoli
- R Rizzoli
- R. Deroisy
- RL Prentice
- RP Heaney
- S Czernichow
- S Rautiainen
- S Silverman
- S. Da Silva
- S. De Niet
- T Hirvonen
- T Pekkarinen
- V Chel
- V Rabenda
- V Rabenda
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Evidence-based cardiovascular care in the community: A population-based cross-sectional study
- Author
- A Fuat
- AK Mantel-Teeuwisse
- Beverley Lawson
- C Gasse
- CA Allen
- CA Jackevicius
- CA Jackevicius
- CH Rojas-Fernandez
- DA Ganz
- David Zitner
- DT Ko
- E Pears
- Frederick I Burge
- Gordon Flowerdew
- HM Krumholz
- Ingrid Sketris
- Investigators Heart Outcomes Prevention Evaluatio
- J Yarzebski
- Jafna L Cox
- JJ Sudano
- JL Cox
- JL Cox
- JN Cohn
- JZ Ayanian
- K Steyn
- K Tu
- KA Dombrook-Lavender
- L Pilote
- MM Mamdani
- N Khan
- OH Klungel
- PA Rochon
- PA Rochon
- R Di Cecco
- R Weiss
- RH Fagard
- S Julius
- SAS Institute Inc.
- Society Canadian Cardiovascular
- SS Anand
- TJ McLaughlin
- W Putnam
- Wayne Putnam
- World Health Organization Collaborating Centre for Drug Statistics Methodology
- Publication venue
- BioMed Central
- Publication date
- 01/04/2004
- Field of study
BACKGROUND: Ischaemic heart disease and congestive heart failure are common and important conditions in family practice. Effective treatments may be underutilized, particularly in women and the elderly. The objective of the study was to determine the rate of prescribing of evidence-based cardiovascular medications and determine if these differed by patient age or sex. METHODS: We conducted a two-year cross-sectional study involving all hospitals in the province of Nova Scotia, Canada. Subjects were all patients admitted with ischaemic heart disease with or without congestive heart failure between 15 October 1997 and 14 October 1999. The main measure was the previous outpatient use of recommended medications. Chi-square analyses followed by multivariate logistic regression analyses were used to examine age-sex differences. RESULTS: Usage of recommended medications varied from approximately 60% for beta-blockers and angiotensin converting enzyme (ACE) inhibitors to 90% for antihypertensive agents. Patients aged 75 and over were significantly less likely than younger patients to be taking any of the medication classes. Following adjustment for age, there were no significant differences in medication use by sex except among women aged 75 and older who were more likely to be taking beta-blockers than men in the same age group. CONCLUSIONS: The use of evidence-based cardiovascular medications is rising and perhaps approaching reasonable levels for some drug classes. Family physicians should ensure that all eligible patients (prior myocardial infarction, congestive failure) are offered beta-blockers or ACE inhibitors
Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at √ s = 8 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abbott DC
- Abeling K
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abud AA
- Abulaiti Y
- Acharya BS
- Achkar B
- Adachi S
- Adam L
- Adamczyk L
- Adamek L
- Adelman J
- Adersberger M
- Adiguzel A
- Adorni S
- Adye T
- Affolder AA
- Afik Y
- Agapopoulou C
- Agaras MN
- Aggarwal A
- Agheorghiesei C
- Aguilar-Saavedra JA
- Ahmadov F
- Ahmed WS
- Ai X
- Aielli G
- Akatsuka S
- Akesson TPA
- Akilli E
- Akimov A
- Al Khoury K
- Alberghi GL
- Albert J
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexopoulos T
- Alfonsi A
- Alfonsi F
- Alhroob M
- Ali B
- Aliev M
- Alimonti G
- Allaire C
- Allbrooke BMM
- Allen BW
- Allport PP
- Aloisio A
- Alonso F
- Alpigiani C
- Alshehri AA
- Alvarez Estevez M
- Alviggi MG
- Amaral Coutinho Y
- Ambler A
- Ambroz L
- Amelung C
- Amidei D
- Amor Dos Santos SP
- Amoroso S
- Amrouche CS
- An F
- Anastopoulos C
- Andari N
- Andeen T
- Anders CF
- Anders JK
- Andreazza A
- Andrei V
- Anelli CR
- Angelidakis S
- Angerami A
- Anisenkov A
- Annovi A
- Antel C
- Anthony MT
- Antipov E
- Antonelli M
- Antrim DJA
- Anulli F
- Aoki M
- Aparisi Pozo JA
- Araque JP
- Araujo Ferraz V
- Araujo Pereira R
- Araya ST
- Arcangeletti C
- Arce ATH
- Arduh FA
- Arguin J-F
- Argyropoulos S
- Arling J-H
- Armbruster AJ
- Armstrong A
- Arnaez O
- Arnold H
- Artoni G
- Artz S
- Asai S
- Asawatavonvanich T
- Asbah N
- Asimakopoulou EM
- Asquith L
- Assahsah J
- Assamagan K
- Astalos R
- Astigarraga MEP
- Atkin RJ
- Atkinson M
- Atlay NB
- Atmani H
- Augsten K
- Avolio G
- Ayoub MK
- Azuelos G
- Bachacou H
- Bachas K
- Backes M
- Backman F
- Bagnaia P
- Bahmani M
- Bahrasemani H
- Bailey AJ
- Bailey VR
- Baines JT
- Bakalis C
- Baker OK
- Bakker PJ
- Balaji S
- Baldin EM
- Balek P
- Balli F
- Balunas WK
- Balz J
- Banas E
- Bandyopadhyay A
- Banerjee S
- Bannoura AAE
- Barak L
- Barbe WM
- Barberio EL
- Barberis D
- Barbero M
- Barbour G
- Barillari T
- Barisits M-S
- Barkeloo J
- Barklow T
- Barnea R
- Barnett BM
- Barnett RM
- Barnovska-Blenessy Z
- Baroncelli A
- Barone G
- Barr AJ
- Barreiro F
- Barsov S
- Bartoldus R
- Bartolini G
- Barton AE
- Bartos P
- Basalaev A
- Basan A
- Bassalat A
- Basso MJ
- Bates RL
- Batlamous S
- Batley JR
- Batool B
- Battaglia M
- Bauce M
- Bauer F
- Bauer KT
- Bawa HS
- Beacham JB
- Beau T
- Beauchemin PH
- Becherer F
- Bechtle P
- Beck HC
- Beck HP
- Becker K
- Becot C
- Beddall A
- Beddall AJ
- Bednyakov VA
- Bedognetti M
- Beermann TA
- Begalli M
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- Behera A
- Behr JK
- Beisiegel F
- Bell AS
- Bella G
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- Bellerive A
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- Beloborodov K
- Belotskiy K
- Belyaev NL
- Benchekroun D
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- Benjamin DP
- Benoit M
- Bensinger JR
- Bentvelsen S
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- Beretta M
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- Berlingen JM
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- Bitadze A
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- Bobbink GJ
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- Bocchetta SS
- Bocci A
- Boeriu OEV
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- Bogdanchikov AG
- Bohm C
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- Bolz AE
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- Bonilla JS
- Boonekamp M
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- Borecka-Bielska HM
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- Borisov A
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- Bortoletto D
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- Burch TJ
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- Burgard CD
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- Cerqueira AS
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- de Renstrom PAB
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- Deviveiros PO
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- Flick T
- Flierl BM
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- Follega FM
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- Garrido MDMC
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- Yexley MR
- Yigitbasi E
- Yildiz HD
- Yorita K
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- Zakharchuk N
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- Zanzi D
- Zaripovas DR
- Zeissner S
- Zeitnitz C
- Zemaityte G
- Zeng JC
- Zenin O
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- Zerwas D
- Zgubic M
- Zhang B
- Zhang DF
- Zhang G
- Zhang H
- Zhang J
- Zhang L
- Zhang M
- Zhang R
- Zhang S
- Zhang X
- Zhang Y
- Zhang Z
- Zhao P
- Zhao Z
- Zhemchugov A
- Zheng Z
- Zhong D
- Zhou B
- Zhou C
- Zhou M
- Zhou MS
- Zhou N
- Zhou Y
- Zhu C
- Zhu CG
- Zhu H
- Zhu HL
- Zhu J
- Zhu Y
- Zhuang X
- Zhukov K
- Zhulanov V
- Zieminska D
- Zimine N
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zivkovic L
- Zobernig G
- Zoccoli A
- Zoch K
- Zorbas TG
- Zou R
- Zu Theenhausen HM
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses 20.3 fb−1 of √ s = 8 TeV data collected in 2012 with the ATLAS detector at the LHC. Events are required to have at least one jet with pT > 120 GeV and no leptons. Nine signal regions are considered with increasing missing transverse momentum requirements between Emiss T > 150 GeV and Emiss T > 700 GeV. Good agreement is observed between the number of events in data and Standard Model expectations. The results are translated into exclusion limits on models with either large extra spatial dimensions, pair production of weakly interacting dark matter candidates, or production of very light gravitinos in a gauge-mediated supersymmetric model. In addition, limits on the production of an invisibly decaying Higgs-like boson leading to similar topologies in the final state are presente
A randomized trial to assess the impact of opinion leader endorsed evidence summaries on the use of secondary prevention strategies in patients with coronary artery disease: the ESP-CAD trial protocol [NCT00175240]
- Author
- 4S Investigators
- AD Oxman
- AJB Brady
- AM Clark
- Antithrombotic Trialists Collaboration
- C Bourgault
- CA Jackevicius
- CB Taylor
- CH Rojas-Fernandez
- Cholesterol Treatment Trialists' (CTT) Collaborators
- CJ Pepine
- CP Cannon
- D McCormick
- DA Davis
- DL Bhatt
- ES Berner
- EUROASPIRE I and II Group
- FA McAlister
- Finlay A McAlister
- FM Sacks
- G Feder
- GG Schwartz
- Heart Outcomes Prevention Evaluation Study Investigators
- Heart Protection Study Collaborative Group
- HJ Dargie
- HV Barron
- J Lomas
- J Shepherd
- J Shepherd
- JA Klinke
- James McMeekin
- JC LaRosa
- Jeremy Grimshaw
- JM Grimshaw
- JR Downs
- JS Benner
- L Pilote
- LK Newby
- M Eccles
- M Eccles
- M Law
- M Underwood
- M Xhignesse
- Merril L Knudtson
- Michelle Graham
- Miriam Fradette
- MM Graham
- N Rehnqvist
- NC Campbell
- PA Heidenreich
- PG Shekelle
- PJ Diggle
- PS Sever
- PWJC Serruys
- R Ashenden
- R Padwal
- Randall Williams
- RG Hiss
- RH Mehta
- RJ De Vries
- RJ Grol
- RM Califf
- Ross T Tsuyuki
- RS Hayward
- RS Hayward
- S Savonitto
- S Yusuf
- SB Soumerai
- SD Fihn
- SF Derose
- SR Majumdar
- SR Majumdar
- SR Majumdar
- SR Majumdar
- SS Gottlieb
- Sumit R Majumdar
- T Von Arnim
- TD Sequist
- TF Pechacek
- The ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group
- The Beta-Blocker Pooling Project Research Group
- The EURopean trial On reduction of cardiac events with Perindopril in stable coronary Artery disease Investigators
- The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group
- The PEACE Trial Investigators
- The Simvastatin/Enalapril Coronary Atherosclerosis Trial (SCAT)
- TJ Wang
- TR Pederen
- WA Ghali
- William A Ghali
- WM Tierney
- WT Lester
- Publication venue
- BioMed Central
- Publication date
- 01/01/2006
- Field of study
BACKGROUND: Although numerous therapies have been shown to be beneficial in the prevention of myocardial infarction and/or death in patients with coronary disease, these therapies are under-used and this gap contributes to sub-optimal patient outcomes. To increase the uptake of proven efficacious therapies in patients with coronary disease, we designed a multifaceted quality improvement intervention employing patient-specific reminders delivered at the point-of-care, with one-page treatment guidelines endorsed by local opinion leaders ("Local Opinion Leader Statement"). This trial is designed to evaluate the impact of these Local Opinion Leader Statements on the practices of primary care physicians caring for patients with coronary disease. In order to isolate the effects of the messenger (the local opinion leader) from the message, we will also test an identical quality improvement intervention that is not signed by a local opinion leader ("Unsigned Evidence Statement") in this trial. METHODS: Randomized trial testing three different interventions in patients with coronary disease: (1) usual care versus (2) Local Opinion Leader Statement versus (3) Unsigned Evidence Statement. Patients diagnosed with coronary artery disease after cardiac catheterization (but without acute coronary syndromes) will be randomly allocated to one of the three interventions by cluster randomization (at the level of their primary care physician), if they are not on optimal statin therapy at baseline. The primary outcome is the proportion of patients demonstrating improvement in their statin management in the first six months post-catheterization. Secondary outcomes include examinations of the use of ACE inhibitors, anti-platelet agents, beta-blockers, non-statin lipid lowering drugs, and provision of smoking cessation advice in the first six months post-catheterization in the three treatment arms. Although randomization will be clustered at the level of the primary care physician, the design effect is anticipated to be negligible and the unit of analysis will be the patient. DISCUSSION: If either the Local Opinion Leader Statement or the Unsigned Evidence Statement improves secondary prevention in patients with coronary disease, they can be easily modified and applied in other communities and for other target conditions
Biofluid Biomarkers in Huntington's Disease
- Author
- A Carrizzo
- A Ciammola
- A Ciammola
- A Dalrymple
- A Kunst
- A McGarry
- A Petersen
- A Petzold
- A Weiss
- A Weiss
- AC Foster
- AD Forrest
- AH Anton
- AJL Cooper
- AL Southwell
- AM Bonnet
- AM Travessa
- AN Anderson
- AS Lazar
- B Borowsky
- B McNamee
- BA Beutler
- BK Puri
- BV Manyam
- C Zuccato
- CA Ross
- CB Dunlap
- CD Johnson
- CF Terrence
- CH Lu
- CM Chen
- CM Forrest
- CM Williams
- CV Russo
- D Bonneh-Barkay
- D Jauch
- DA Jauch
- DE Paglia
- DL Murphy
- DM St Clair
- E Bonilla
- E Caine
- E Cattaneo
- E Kalliolia
- E Salvatore
- E Silajdzic
- E Wild
- EB Johnson
- EE Muller
- EJ Wild
- EJ Wild
- EJ Wild
- EJ Wild
- F Borovecki
- F Bozzo
- F Cesca
- F Karege
- F Leblhuber
- F Leblhuber
- F Mochel
- F Nicoli
- F Sanchez-Lopez
- F Squitieri
- F Squitieri
- FB Rodrigues
- FB Rodrigues
- FB Rodrigues
- FB Rodrigues
- FB Rodrigues
- G Battaglia
- G Curzon
- G Curzon
- G Tell
- GA Graveland
- GP Reynolds
- GW Bruyn
- GW Bruyn
- H Aebi
- H Runne
- H Zetterberg
- HC Hyson
- HD Rosas
- HJ Keogh
- HL Klawans
- HP Kremer
- Huntington Study Group
- Huntington Study Group T-HDI
- I Banegas
- I Carlberg
- I Ciancarelli
- I Ciancarelli
- I Tasset
- IJ Heuser
- J Christofides
- J Gaiottino
- J Kim
- J Korf
- J Korf
- J Krzyszton-Russjan
- J Passonneau
- J Sedlak
- JA Bouwens
- JA Oates
- JC Rojas
- JD Long
- JD Rohrer
- JF Gusella
- JHL Klawans
- JJ Ferreira
- JJ Pisano
- JK Saelens
- JM Burg van der
- JR Miller
- JS Kim
- JS Paulsen
- K Belendiuk
- K Josefsen
- K Sathasivam
- K Varani
- K Varani
- K-H Chang
- KM Biglan
- KM Biglan
- L Lorigados
- L Lovrecic
- L Lovrecic
- L Massai
- L Murri
- L Vecsei
- L Wagner
- LH Meeter
- LM Byrne
- LM Byrne
- LT Graham Jr
- M Björkqvist
- M Björkqvist
- M Björkqvist
- M Björkqvist
- M Bogdanov
- M Fernandez-Nogales
- M Gisslen
- M Hartog
- M Markianos
- M Markianos
- M Markianos
- M Markianos
- M Moscovitch-Lopatin
- M Moscovitch-Lopatin
- M Pena-Sanchez
- M Radomski
- MC Garrett
- MF Beal
- MG Olsson
- MP Heyes
- MP Heyes
- MP Heyes
- MR Hayden
- MW McCaman
- N Battista
- N Klepac
- N Mattsson
- N Saleh
- N Saleh
- N Stoy
- NA Aziz
- NA Aziz
- NA Aziz
- NA Aziz
- NA Aziz
- NI Wood
- NJ Cairns
- NM Lalic
- NN Aronson
- NV Manyam
- NVB Manyam
- OT Phillipson
- OT Phillipson
- P Böhlen
- P Guidetti
- P Paganetti
- P Steinacker
- PJ García Ruiz
- PJ Lavin
- PJ Morrison
- PM Gaughwin
- PS MacFarlane
- PW Gold
- Q Fang
- R Constantinescu
- R Constantinescu
- R Duran
- R Durso
- R Durso
- R Kurlan
- R Reilmann
- R Reilmann
- R Schwarcz
- R Vuono
- R Wang
- R Wetzel
- RJ Chalmers
- S Consolo
- S Fraser
- S Fukui
- S Laurell
- S Marklund
- S Podolsky
- S Uhlhaas
- S Uhlhaas
- SE Gaus
- SH Li
- SJ Enna
- SJ Pearson
- SJ Tabrizi
- SJ Tabrizi
- SJ Tabrizi
- SJ Tabrizi
- SK Barodia
- SM Hersch
- T Caraceni
- T Caraceni
- T Nagatsu
- T Vinther-Jensen
- T Vinther-Jensen
- T Vinther-Jensen
- The Huntington’s Disease Collaborative Research Group
- TJ Montine
- TJ Montine
- TJ Montine
- TM Jeitner
- TM Jeitner
- U Trager
- V Fodale
- V Leoni
- V Leoni
- V Maglione
- V Maglione
- V Niemela
- V Niemelä
- V Popovic
- V Witko-Sarsat
- VK Weise
- W Merens
- W Weiner
- WA Banks
- WD Denckla
- WS Griffin
- Y Hu
- Y-C Huang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
Huntington's disease (HD) is a chronic progressive neurodegenerative condition where new markers of disease progression are needed. So far no disease-modifying interventions have been found, and few interventions have been proven to alleviate symptoms. This may be partially explained by the lack of reliable indicators of disease severity, progression, and phenotype.Biofluid biomarkers may bring advantages in addition to clinical measures, such as reliability, reproducibility, price, accuracy, and direct quantification of pathobiological processes at the molecular level; and in addition to empowering clinical trials, they have the potential to generate useful hypotheses for new drug development.In this chapter we review biofluid biomarker reports in HD, emphasizing those we feel are likely to be closest to clinical applicability
Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4.4 million participants
- Author
- Abdeen ZA
- Abu-Rmeileh NM
- Acosta-Cazares B
- Adams R
- Aekplakorn W
- Aguilar-Salinas CA
- Agyemang C
- Ahmadvand A
- Al Nsour M
- Al-Othman AR
- Ali MK
- Alkerwi A
- Amouyel P
- Amuzu A
- Andersen LB
- Anderssen SA
- Anjana RM
- Aounallah-Skhiri H
- Aris T
- Arlappa N
- Arveiler D
- Assah FK
- Avdicova M
- Azizi F
- Balakrishna N
- Bandosz P
- Barbagallo CM
- Barcelo A
- Batieha AM
- Baur LA
- Ben Romdhane H
- Ben Romdhane H
- Benet M
- Bennett JE
- Bentham J
- Bernabe-Ortiz A
- Bharadwaj S
- Bhargava SK
- Bi Y
- Bixby H
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- van Valkengoed IGM
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- Zuniga Cisneros J
- Publication venue
- Publication date
- 09/04/2016
- Field of study
BACKGROUND: One of the global targets for non-communicable diseases is to halt, by 2025, the rise in the age-standardised adult prevalence of diabetes at its 2010 levels. We aimed to estimate worldwide trends in diabetes, how likely it is for countries to achieve the global target, and how changes in prevalence, together with population growth and ageing, are affecting the number of adults with diabetes. METHODS: We pooled data from population-based studies that had collected data on diabetes through measurement of its biomarkers. We used a Bayesian hierarchical model to estimate trends in diabetes prevalence—defined as fasting plasma glucose of 7·0 mmol/L or higher, or history of diagnosis with diabetes, or use of insulin or oral hypoglycaemic drugs—in 200 countries and territories in 21 regions, by sex and from 1980 to 2014. We also calculated the posterior probability of meeting the global diabetes target if post-2000 trends continue. FINDINGS: We used data from 751 studies including 4 372 000 adults from 146 of the 200 countries we make estimates for. Global age-standardised diabetes prevalence increased from 4·3% (95% credible interval 2·4–7·0) in 1980 to 9·0% (7·2–11·1) in 2014 in men, and from 5·0% (2·9–7·9) to 7·9% (6·4–9·7) in women. The number of adults with diabetes in the world increased from 108 million in 1980 to 422 million in 2014 (28·5% due to the rise in prevalence, 39·7% due to population growth and ageing, and 31·8% due to interaction of these two factors). Age-standardised adult diabetes prevalence in 2014 was lowest in northwestern Europe, and highest in Polynesia and Micronesia, at nearly 25%, followed by Melanesia and the Middle East and north Africa. Between 1980 and 2014 there was little change in age-standardised diabetes prevalence in adult women in continental western Europe, although crude prevalence rose because of ageing of the population. By contrast, age-standardised adult prevalence rose by 15 percentage points in men and women in Polynesia and Micronesia. In 2014, American Samoa had the highest national prevalence of diabetes (>30% in both sexes), with age-standardised adult prevalence also higher than 25% in some other islands in Polynesia and Micronesia. If post-2000 trends continue, the probability of meeting the global target of halting the rise in the prevalence of diabetes by 2025 at the 2010 level worldwide is lower than 1% for men and is 1% for women. Only nine countries for men and 29 countries for women, mostly in western Europe, have a 50% or higher probability of meeting the global target. INTERPRETATION: Since 1980, age-standardised diabetes prevalence in adults has increased, or at best remained unchanged, in every country. Together with population growth and ageing, this rise has led to a near quadrupling of the number of adults with diabetes worldwide. The burden of diabetes, both in terms of prevalence and number of adults affected, has increased faster in low-income and middle-income countries than in high-income countries. FUNDING: Wellcome Trust
Multi-messenger observations of a binary neutron star merger
- Author
- Aab A
- Aartsen MG
- Abbott BP
- Abbott R
- Abbott TD
- Abbott TMC
- Abdalla H
- Abe F
- Abeysekara AU
- Abramo LR
- Abramowski A
- Abreu P
- Acernese F
- Acero F
- Ackermann M
- Ackley K
- Ackley K
- Adams C
- Adams J
- Adams SM
- Adams T
- Addesso P
- Adhikari RX
- Adya VB
- Affeldt C
- Afrough M
- Agarwal B
- Agathos M
- Agatsuma K
- Aggarwal N
- Aglietta M
- Agliozzo C
- Agudo I
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- Aguilar JA
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- Ajith P
- Akras S
- Al Samarai I
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- Albuquerque IFM
- Albury JM
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- Alighieri S Di Serego
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- Salvadori I
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- Sampedro L
- Sampson LM
- Samtleben DFE
- Sanchez B
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- Sanchez LE
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- Schoenen S
- Schofield RMS
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- Schonbeck A
- Schoneberg S
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- Schreiber E
- Schroder FG
- Schroder S
- Schroder SL
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- Sciutto SJ
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- Sekiguchi Y
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- Sevilla-Noarbe I
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- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2017
- Field of study
On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transient’s position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta
Use of anticoagulants and antiplatelet agents in stable outpatients with coronary artery disease and atrial fibrillation. International CLARIFY registry
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- A. L. R. Ng
- Abardia Oliva F. J.
- Abdel Malak S.
- Abdel Wahab H.
- Abdul Kareem B. B.
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- Weglarz M.
- Wehr G.
- Wei J.
- Weingrod M.
- Weinrich L.
- Weinrich R.
- Wellenkamp E.
- Wernham C.
- West P.
- Wettstein T.
- Weytjens C.
- Whetstone S.
- Widimsky P.
- Wiggers P.
- Wilkinson I.
- Williams H.
- Williams S.
- Wilson G.
- Windstetter U.
- Winter M.
- Wirtz J. H.
- Wittekoek J. E.
- Wittlich N.
- Wong A. P. T.
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- Wong P.
- Wongcharoen W.
- Woodall A.
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- Wu Amen L.
- Wu D.
- Wu G.
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- Wu S.
- Wu Y.
- Wysocki R.
- Xiao J.
- Xie J.
- Xie X.
- Xie Y.
- Xing Y.
- Xiong C.
- Xiong L.
- Xu D.
- Xu M.
- Xu W.
- Xu Z.
- Xue H.
- Xue M.
- Yakimova N.
- Yakovenko E.
- Yakovova S.
- Yan J.
- Yan X.
- Yanes Bowden G.
- Yanez Wonenburger J. C.
- Yang F.
- Yang H.
- Yang K.
- Yang M.
- Yang Q.
- Yang X.
- Yang Y.
- Yanina Y.
- Yanni N.
- Yao E.
- Yao X.
- Yao Y.
- Yared K.
- Yeo C. K.
- Yeung M. M. M.
- Yip T.
- Yordanova V.
- Yu A.
- Yu B.
- Yu G.
- Yu M.
- Yu X.
- Yuan C.
- Yusuf A.
- Yusufali A.
- Yvorra S.
- Zaca F.
- Zachos V.
- Zagozen P.
- Zagreanu M.
- Zakirova V.
- Zakopoulos C.
- Zalewska D.
- Zamorano Gomez J. L.
- Zamorano J. L.
- Zaoral L.
- Zarauza Navarro J.
- Zarechnova S.
- Zaronskiene D.
- Zatsarina E.
- Zdrojewska J.
- Zeitouni R.
- Zhabina L.
- Zhang A.
- Zhang C.
- Zhang G.
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- Zhang J.
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- Zhang S.
- Zhang X.
- Zhang Y.
- Zhao G.
- Zhao H.
- Zhao R.
- Zhao S.
- Zhao Y.
- Zharikova L.
- Zheng S.
- Zheng X.
- Zheng Y.
- Zherebtsova A.
- Zherlitsyna E.
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- Zhu J.
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- Ziak E.
- Ziccarelli C.
- Ziehn P.
- Zimolag R.
- Zundorf P.
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2015
- Field of study
- …