110 research outputs found
Phase separation in t-J ladders
The phase separation boundary of isotropic t-J ladders is analyzed using
density matrix renormalization group techniques. The complete boundary to phase
separation as a function of J/t and doping is determined for a chain and for
ladders with two, three and four legs. Six-chain ladders have been analyzed at
low hole doping. We use a direct approach in which the phase separation
boundary is determined by measuring the hole density in the part of the system
which contains both electrons and holes. In addition we examine the binding
energy of multi-hole clusters. An extrapolation in the number of legs suggests
that the lowest J/t for phase separation to occur in the two dimensional t-J
model is J/t~1.Comment: 8 pages in revtex format including 13 embedded figures, one reference
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Spin Glass Behavior in RuSr2Gd1.5Ce0.5Cu2O10
The dynamics of the magnetic properties of polycrystalline
RuSr2Gd1.5Ce0.5Cu2O10 (Ru-1222) have been studied by ac susceptibility and dc
magnetization measurements, including relaxation and ageing studies. Ru-1222 is
a reported magneto-superconductor with Ru spins magnetic ordering at
temperatures near 100 K and superconductivity in Cu-O2 planes below Tc ~ 40 K.
The exact nature of Ru spins magnetic ordering is still debated and no
conclusion has been reached yet. In this work, a frequency-dependent cusp was
observed in ac susceptibility vs. T measurements, which is interpreted as a
spin glass transition. The change in the cusp position with frequency follows
the Vogel-Fulcher law, which is commonly accepted to describe a spin glass with
magnetically interacting clusters. Such interpretation is supported by
themoremanaent magnetization (TRM) measurements at T = 60 K. TRM relaxations
are well described by a stretched exponential relation, and present significant
ageing effects.Comment: 4 pages, 6 figures, submitted to Phys. Rev.
Spatially homogeneous ground state of the two-dimensional Hubbard model
We investigate the stability with respect to phase separation or charge
density-wave formation of the two-dimensional Hubbard model for various values
of the local Coulomb repulsion and electron densities using Green-function
Monte Carlo techniques. The well known sign problem is particularly serious in
the relevant region of small hole doping. We show that the difference in
accuracy for different doping makes it very difficult to probe the phase
separation instability using only energy calculations, even in the
weak-coupling limit () where reliable results are available. By contrast,
the knowledge of the charge correlation functions allows us to provide clear
evidence of a spatially homogeneous ground state up to .Comment: 7 pages and 5 figures. Phys. Rev. B, to appear 200
Phase separation and stripe formation in the 2D t-J model: a comparison of numerical results
We make a critical analysis of numerical results for and against phase
separation and stripe formation in the t-J model. We argue that the frustrated
phase separation mechanism for stripe formation requires phase separation at
too high a doping for it to be consistent with existing numerical studies of
the t-J model. We compare variational energies for various methods, and
conclude that the most accurate calculations for large systems appear to be
from the density matrix renormalization group. These calculations imply that
the ground state of the doped t-J model is striped, not phase separated.Comment: This version includes a revised, more careful comparison of numerical
results between DMRG and Green's function Monte Carlo. In particular, for the
original posted version we were accidentally sent obsolete data by Hellberg
and Manousakis; their new results, which are what were used in their Physical
Review Letter, are more accurate because a better trial wavefunction was use
Magnetization study of RuSr2Y1.5Ce 0.5Cu2O10 (Ru-1222)
We have studied the magnetic properties of the non-superconducting
RuSr2Ln1.5Ce0.5Cu2O10 (Ln=Y, Dy and Ho, Ru-1222) compounds synthesized under
high pressure (6 Gpa) at elevated temperature. The materials become
magnetically ordered at TM =152(2) K regardless of Ln. The wide
ferromagnetic-like hysteresis loops which open at 5 K, close themselves around
Tirr= 90-100 K and the remanent magnetizations (Mrem) and the coercive fields
(HC) become zero. Surprisingly, at Tirr<T< TM a reappearance of the Mrem and HC
(with a peak at 120-130 K) is observed for all three samples studied. For the
non-magnetic Ln=Y compound, the extracted saturation moment at 5 K and the
effective paramagnetic moment are is 0.75 and 2.05 mB /Ru, values which are
close to the expected 1 mB and 1.73 mB respectively, for the low-spin state of
Ru5+. We argue that the Ru-1222 system becomes (i) anti-ferromagnetically (AFM)
ordered at TM. In this range a metamagnetic transition is induced by the
applied field (ii). At Tirr < TM, weak-ferromagnetism (W-FM) is induced by the
canting of the Ru moments.Comment: 15 pages of text with figure. Submitted to Phys. Rev.
Stripes, Pseudogaps, and Van Hove Nesting in the Three-band tJ Model
Slave boson calculations have been carried out in the three-band tJ model for
the high-T_c cuprates, with the inclusion of coupling to oxygen breathing mode
phonons. Phonon-induced Van Hove nesting leads to a phase separation between a
hole-doped domain and a (magnetic) domain near half filling, with long-range
Coulomb forces limiting the separation to a nanoscopic scale. Strong
correlation effects pin the Fermi level close to, but not precisely at the Van
Hove singularity (VHS), which can enhance the tendency to phase separation. The
resulting dispersions have been calculated, both in the uniform phases and in
the phase separated regime. In the latter case, distinctly different
dispersions are found for large, random domains and for regular (static)
striped arrays, and a hypothetical form is presented for dynamic striped
arrays. The doping dependence of the latter is found to provide an excellent
description of photoemission and thermodynamic experiments on pseudogap
formation in underdoped cuprates. In particular, the multiplicity of observed
gaps is explained as a combination of flux phase plus charge density wave (CDW)
gaps along with a superconducting gap. The largest gap is associated with VHS
nesting. The apparent smooth evolution of this gap with doping masks a
crossover from CDW-like effects near optimal doping to magnetic effects (flux
phase) near half filling. A crossover from large Fermi surface to hole pockets
with increased underdoping is found. In the weakly overdoped regime, the CDW
undergoes a quantum phase transition (), which could be obscured
by phase separation.Comment: 15 pages, Latex, 18 PS figures Corrects a sign error: major changes,
esp. in Sect. 3, Figs 1-4,6 replace
Replication of genetic loci for ages at menarche and menopause in the multi-ethnic Population Architecture using Genomics and Epidemiology (PAGE) study
Do genetic associations identified in genome-wide association studies (GWAS) of age at menarche (AM) and age at natural menopause (ANM) replicate in women of diverse race/ancestry from the Population Architecture using Genomics and Epidemiology (PAGE) Study
Growth Hormone Research Society perspective on biomarkers of GH action in children and adults
Objective
The Growth Hormone Research Society (GRS) convened a Workshop in 2017 to evaluate clinical endpoints, surrogate endpoints and biomarkers during GH treatment of children and adults and in patients with acromegaly.
Participants
GRS invited 34 international experts including clinicians, basic scientists, a regulatory scientist and physicians from the pharmaceutical industry.
Evidence
Current literature was reviewed and expert opinion was utilized to establish the state of the art and identify current gaps and unmet needs.
Consensus process
Following plenary presentations, breakout groups discussed questions framed by the planning committee. The attendees re-convened after each breakout session to share the group reports. A writing team compiled the breakout session reports into a document that was subsequently discussed and revised by participants. This was edited further and circulated for final review after the meeting. Participants from pharmaceutical companies were not part of the writing process.
Conclusions
The clinical endpoint in paediatric GH treatment is adult height with height velocity as a surrogate endpoint. Increased life expectancy is the ideal but unfeasible clinical endpoint of GH treatment in adult GH-deficient patients (GHDA) and in patients with acromegaly. The pragmatic clinical endpoints in GHDA include normalization of body composition and quality of life, whereas symptom relief and reversal of comorbidities are used in acromegaly. Serum IGF-I is widely used as a biomarker, even though it correlates weakly with clinical endpoints in GH treatment, whereas in acromegaly, normalization of IGF-I may be related to improvement in mortality. There is an unmet need for novel biomarkers that capture the pleiotropic actions of GH in relation to GH treatment and in patients with acromegaly
Large expert-curated database for benchmarking document similarity detection in biomedical literature search
Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe
A century of trends in adult human height
Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to estimate mean height for people born between 1896 and 1996 in 200 countries. The largest gain in adult height over the past century has occurred in South Korean women and Iranian men, who became 20.2 cm (95% credible interval 17.5-22.7) and 16.5 cm (13.3-19.7) taller, respectively. In contrast, there was little change in adult height in some sub-Saharan African countries and in South Asia over the century of analysis. The tallest people over these 100 years are men born in the Netherlands in the last quarter of 20th century, whose average heights surpassed 182.5 cm, and the shortest were women born in Guatemala in 1896 (140.3 cm; 135.8-144.8). The height differential between the tallest and shortest populations was 19-20 cm a century ago, and has remained the same for women and increased for men a century later despite substantial changes in the ranking of countries
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