Ultrasound Assisted Facile Synthesis of 2-Benzylidenebenzofuran-3(2H)-ones

2-Benzylidenebenzofuran-3(2H)-ones commonly known as aurones, are an important class of oxygen heterocyclic compounds of flavonoid family. They exhibit some biological activities such as antioxidant, antifungal, anticancer, enzyme inhibitory, antiparasitic and antileishmanial activities. They are also responsible for imparting yellow color to the flowers and fruits. Owing to their varied importance, a simple and efficient method for the synthesis of 2-benzylidenebenzofuran-3(2H)-ones involving the reaction of 1-(2'-hydroxy-phenyl)-3-phenyl-propenones with copper acetate in ethanol under ultrasonic irradiation conditions has been described. The present method offers a faster reaction and a higher yield than conventional methods

Late recovery of phrenic nerve palsy in a neonate: A case report

Hyperextension of the neck at birth can injure the phrenic nerve and/or brachial plexus usually at the point where the phrenic nerve crosses the brachial plexus. We present a case of the preterm baby, who had Erb’s palsy and diaphragmatic paralysis since birth after breech delivery. Persistent respiratory distress and chest X-ray gave a clue to diagnosis, which was confirmed on ultrasound. The baby recovered on the conservative approach at 2 months of life without surgical plication. This study describes that late spontaneous recovery up to 2 months is possible in a newborn with respiratory distress due to phrenic nerve palsy

SpiroMask: Measuring Lung Function Using Consumer-Grade Masks

According to the World Health Organisation (WHO), 235 million people suffer from respiratory illnesses and four million people die annually due to air pollution. Regular lung health monitoring can lead to prognoses about deteriorating lung health conditions. This paper presents our system SpiroMask that retrofits a microphone in consumer-grade masks (N95 and cloth masks) for continuous lung health monitoring. We evaluate our approach on 48 participants (including 14 with lung health issues) and find that we can estimate parameters such as lung volume and respiration rate within the approved error range by the American Thoracic Society (ATS). Further, we show that our approach is robust to sensor placement inside the mask.Comment: Accepted in the ACM Transactions on Computing for Healthcare (HEALTH

Multi-band Extension of the Wideband Timing Technique

The wideband timing technique enables the high-precision simultaneous estimation of Times of Arrival (ToAs) and Dispersion Measures (DMs) while effectively modeling frequency-dependent profile evolution. We present two novel independent methods that extend the standard wideband technique to handle simultaneous multi-band pulsar data incorporating profile evolution over a larger frequency span to estimate DMs and ToAs with enhanced precision. We implement the wideband likelihood using the libstempo python interface to perform wideband timing in the tempo2 framework. We present the application of these techniques to the dataset of fourteen millisecond pulsars observed simultaneously in Band 3 (300 - 500 MHz) and Band 5 (1260 - 1460 MHz) of the upgraded Giant Metrewave Radio Telescope (uGMRT) as a part of the Indian Pulsar Timing Array (InPTA) campaign. We achieve increased ToA and DM precision and sub-microsecond root mean square post-fit timing residuals by combining simultaneous multi-band pulsar observations done in non-contiguous bands for the first time using our novel techniques.Comment: Submitted to MNRA

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

Strangulation injury from indigenous rocking cradle

Indigenously made rocking cradle is frequently used in rural India. We report strangulation from an indigenously made rocking cradle in an 11-month-old female child. The unique mode of injury and its mechanism have been discussed. Strangulation is an important cause of homicidal and suicidal injury in adults but in children it is usually accidental leading to death due to asphyxia as a result of partial hanging. In western countries, it is the third most common cause of accidental childhood deaths, 17% of them being due to ropes and cords. It ranks fourth amongst the causes of unintentional injury in children less than 1 year of age following roadside accidents, drowning and burns. However, in India, strangulation injury is under reported although indigenous rocking cradles are very commonly used in rural India, and they are even more dangerous than the cribs and adult beds as there are no safety mechanisms therein. We report a case of accidental strangulation following suspension from an indigenously made rocking cradle. The unique mode of injury has prompted us to report this case

Thermometry in children

Accurate measurement of temperature is important for detection of fever and hypothermia in pediatric patients. Ideal temperature-measurement technique should be safe, easy, noninvasive, cost effective, time efficient, and should precisely reflect core body temperature. Pulmonary artery is the closest to hypothalamus and best reflects the core temperature. Other sites used are distal esophagus, urinary bladder and nasopharynx. All these methods are invasive and difficult to use in clinical practice. Amongst the noninvasive methods, rectal thermometry is considered to be the closest to core temperature, but it has its own drawbacks. With the current evidence available, tympanic artery thermometry for children more than 2 years of age and temporal artery thermometry in all age groups are taking precedence over other methods