Absorption spectra of the dibenzofluorene derivative belonging to the KuQuinones family

A detailed study of the UV-Vis spectra of the dibenzofluorene derivative belonging to the KuQuinones family was carried out in polar aprotic (CH3CN), polar protic (CH3OH), and slightly polar (CHCl3) solvents. The spectral properties of this compound underscore its similarity to other KuQuinones on the one hand, while on the other hand they confirm that it is not a planar but a three-dimensional (3D) structure with separated charges. The existence of keto–enol tautomerization and acid-base equilibrium under different pH conditions has also been investigated

Repeated Use of Purified Wastewater in the Dyeing of Polyether Fabrics with Dispersed Dyes

The article presents the results of reuse of treated wastewater from the dyeing and finishing production in the technology of fabric dyeing. The wastewater is purified by adsorption using natural zeolite, followed by coagulation and flocculation. The purified water is reused in the process of dyeing polyester fabric with dispersed dyes of Dark Blue Z, Red 2C, Yellow Stable 2K. They ensure the intensity of fabric coloring at 95-99.9% compared to 100%. The stability of the obtained color is at the level of 2-4 points according to the greyscale. The double treatment of the same wastewater makes it easy to dye Polyether fabric with dispersed Dark Blue Z dye

Differential Pulse Cathodic Voltammetric Determination of Metopimazine in Dosage Forms through Treatment with Oxone

A simple, rapid and sensitive voltammetric method for determining Metopimazine (MPZ) as its sulfoxide was developed. The Metopimazine sulfoxide derivative (MPZO) is formed quickly and quantitatively at room temperature by adding potassium caroate solution. Well-defined cathodic waves were obtained for MPZO in 0.02 mol/L HCl using the differential-pulse mode at the hanging mercury drop electrode (HMDE). It is shown that the limiting stage of the MPZO reduction process is the adsorption of MPZO on the electrode surface. Factors affecting the peak current were studied and optimised. The current–concentration relationship was linear over the 0.4-2.7 µg/mL ranges for MPZ, respectively. The technique has been developed and the possibility of quantitative determination of Metopimazine in Vogalene Lyoc 7.5 mg tablets by an indirect voltammetric method using potassium caroate (Oxone) as an oxidising agent has been shown. RSD was ≤1.63% (δ = –0.40…..–1.07%), where δ = (-µ)·100%/µ, and µ is the average value of the quantitative determination by reference spectrophotometric method. According to the data of the linear part of the calibration graph, the limit of detection (LOD) and the limit of quantification (LOQ) were calculated, which are 0.1 μg/mL and 0.4 μg/mL, respectively. The method is specific for an intact drug in the presence of oxidative and photochemical decomposition products and excipients

Investigating the Bioactive Compounds of Moringa and Garlic in the Treatment of Chronic Diseases: A Comprehensive Review

Herbal remedies have been used for centuries to treat various ailments. Natural products, derived from plants, animals, and microorganisms, have been used for centuries as a source of medicinal compounds in traditional and modern herbal remedies. Understanding the chemical properties herbal remedies is crucial for their effective and safe application in managing chronic diseases. This review explores the chemical properties and mechanisms of two potent herbal remedies, Moringa oleifera and Garlic (Allium sativum L.) in managing chronic diseases such as diabetes, cardiovascular diseases, and autoimmune disorders. It emphasizes the need for a balanced approach combining herbal and conventional medicine, reducing healthcare costs and improving patient outcomes. The review includes 10 studies investigating the efficacy of herbal remedies in managing chronic diseases in Moringa and Ginger. The study revealed that Moringa oleifera, a valuable plant in traditional and modern medicine, has diverse therapeutic effects, making it beneficial for managing chronic diseases. Garlic, a powerful herbal remedy with bioactive compounds, is also considered a powerful natural treatment due to its antioxidant, anti-inflammatory, antimicrobial, antiemetic, and anticancer activities. The therapeutic potential of moringa and garlic in managing chronic diseases is underscored by their ability to alleviate symptoms and improve health outcomes through natural mechanisms. This review highlights the importance of integrating these herbal remedies into conventional medical practices to enhance disease management, promote overall well-being and develop effective treatments for chronic diseases and enhance their integration into modern medicine

Occurrence of Heavy Metals Concentration in Grown Food Crops (Manihot esculenta and Colocasia esculenta) around Disused Ogbete Coal Mine in Enugu Metropolis, South Eastern Nigeria

The major food crops frequently consumed by communities in southeastern Nigeria are Manihot esculenta (cassava) and Colocasia esculenta (cocoyam). The crops are sometimes grown in disused mining sites. The study was carried out in Ogbete disused coal mine area, GRA (government residential area) Enugu, in Enugu State, Nigeria. the study area is located between latitude 6̊ 27̍ N and 35.8704̎ N and longitude7̊ 32̍ E and 56.2164̎ E. This study was conducted to assess the occurrence and concentration of heavy metals in the soil and crop samples. The five heavy metals studied were (Cd, Cr, Zn, Ni and Pb). The samples included twenty-four crops of which eighteen were collected from three sampling locations. The study shows that food grown in the site could pose health risks. The study recommends the ongoing monitoring of heavy metal concentration in the study area

Mannich Bases of Chromones Containing a 2,3-fused Heterocyclic Ring

Aminomethylation of chromones сontaining a 2,3-fused heterocyclic ring, such as indolizine, pyrroloquinoline and pyrrolothiazole, namely 9-hydroxy-6/8-alkyl-12H-chromeno[3,2-a]indolizin-12-ones, 10-(alk)oxy-9-R-7Н-сhromeno[3',2':3,4]pyrrolo[1,2-а]quinolin-7-ones and 9-alkyl-8-hydroxy-3-methyl-5-R-11H-chromeno[3’,2’:3,4]pyrrolo[2,1-b][1,3]thiazol-11-ones with bisdialkylaminomethanes was studied. The α-position of the pyrrole ring and the ortho-positions to the hydroxyl group in the benzene ring in the above mentioned systems are active sites and the Mannich reaction can occur at these three positions as shown for 10-hydroxy-7Н-сhromeno[3',2':3,4]pyrrolo[1,2-а]quinolin-7-one yielding 9,11,13-tri(dialkylaminomethyl) derivative. Using the strategy of introducing substituents into the active centers, as well as replacing the OH group with OAlk, it was possible to obtain mono- and diaminomethylation products. The above systems substituted at positions 6 or 8 of the chromone ring afforded di(dialkylaminomethyl) products, respectively 5,7-di(dimethylaminomethyl)-9-alkyl-8-hydroxy-3-methyl-11H-chromeno[3’,2’:3,4]pyrrolo[2,1-b][1,3]thiazol-11-ones, 6,8- or 6,10-di(dimethylaminomethyl)-8/10-alkyl-9-hydroxy-12H-chromeno[3,2-a]indolizin-12-ones and 11,13-di(dialkylaminomethyl)-9-ethyl-10-hydroxy-7Н-сhromeno[3',2':3,4]pyrrolo[1,2-а]quinolin-7-ones. Monoaminomethylated products were prepared for 5-acyl-8-hydroxy-3-methyl-11H-chromeno[3’,2’:3,4]pyrrolo[2,1-b][1,3]thiazol-11-ones. Aminomethylation of 10-alkoxy-7Н-сhromeno[3',2':3,4]pyrrolo[1,2-а]quinolin-7-ones occurred only at the pyrrole ring, giving 10-alkoxy-13-dimethylaminomethyl derivatives. Taking into account that derivatives of 7Н-сhromeno[3',2':3,4]pyrrolo[1,2-а]quinolin-7-one system exhibited hypoglicemic and anabolic activities, the obtained Mannich bases may be of interest as potential biologically active substances

Enantioselective Catalyzed Addition of Substituted Indens to Unsaturated Epoxides

Unsaturated aromatic epoxides can be regioselectively opened by substituted indenes in the presence of catalytic amounts of (R)-1,1'-bi-2,2'-naphthotitanium diisopropoxide (1 mol%). The reaction proceeds and enables the synthesis of (1R,2R)-2-(5-bromo-1H-inden-3-yl)-2-phenyl-1-[(prop-2-yn-1-yl)oxy]propan-1-ol with moderate yield and high enantioselectivity (ee up to 97%)

Usage of Rice Husk for the Production of Low-Temperature Cement: Physico-Chemical and Technological Aspects

The aim of the work was to deepen scientific understanding of the physicochemical aspects of phase formation of silicate systems of the CaO-SiO2-Al2O3 type when using rice husk as a silica-containing component of technogenic origin. The research methods included a complex of chemical, X-ray phase analyses, computer calculations and technological testing of materials. Based on the analysis of the results of calculations regarding compliance with the required values of the cement modulus characteristics, possible quantitative ratios of the carbonate component and rice husk were determined. As a result of technological testing, the compositions of the initial binary mixture based on marl with a content of up to 28 wt. % rice husk were determined, which ensures the production of a mineral binder - an analogue of Roman cement with an increase in strength indicators by 1.5 times. According to the data of X-ray phase analysis, the peculiarities of physicochemical transformations during the firing of the compositions were established, which are associated with the increased reactivity of amorphous rice husk silica to phase formation with a change in the quantitative ratio of crystalline phases of calcium silicates, the development of C2AS and A3S2 phases distributed in the glass phase. A conclusion was made about the possibility and feasibility of using rice husk to produce cement fired by low temperature for a comprehensive solution to the issues of chemical technology and resource saving

Analysis of the complex of adaptive and compensatory changes in chronic inflammation of the reproductive system based on the evaluation of the features of the spectrum of cytochemical indicators of the activity of circulating and tissue leukocytes

Physiological processes occurring in the human body are reflected in cellular metabolism. One of the criteria for assessing the state of human health is the study of the features of the cytochemical indicators of the activity of circulating and tissue leukocytes, which react especially subtly to functional and pathological changes, reflecting multifactorial internal processes that affect the organism of the subject and provide important information about the reactivity of the organism and the severity of the course disease. The state of the cytochemical spectrum of these cells reflects reactive changes in the macroorganism, and makes it possible to determine the depth and direction of the pathological process. These studies at the cellular level can detect adaptive and compensatory changes in metabolism even when the cells do not change morphologically

Beckmann Fragmentation of Camphor-4-carboxylic and Camphor-4-acetic Acid Oximes

A mild and efficient recyclization reaction of bornanone-4-carboxylic and bornanone-4-acetic acid oximes in aqueous hydrochloric acid has been developed. Beckmann fragmentation followed by hydrolysis provides a straightforward method for the preparation and isolation of functionalized [2.2.1] and [3.3.0] bicyclic lactones in nearly quantitative yields. These simple transformations offer the opportunity to obtain a wide range of more complex functionalized bicyclic terpenoids on a large-scale, starting from readily available camphor derivatives