Delayed presentation of congenital diaphragmatic hernia: a case report

Congenital diaphragmatic hernia (CDH) is known as a structural defect caused by inadequate fusion of the pleuroperitoneal membrane forming the diaphragm, allowing peritoneal viscera to protrude into the pleural cavity. It affects nearly one out of 2500 live births. We here report the case of a six-month-old boy with left diaphragmatic hernia presenting with poor feeding, breathing difficulty, cough, and recurrent pneumonia in the last 2 months. Chest X-ray and computed tomography scan revealed left sided CDH. The defect was corrected through open surgical repair without complications. At 5-month follow-up a radiograph was performed which revealed full recovery. The primary goal of this report was to alert physicians to suspect this diagnosis in patients with unexpected presentation of diaphragmatic hernia

Medication Sector in Qatar: Hand in Hand Facing the Blockade

Conference agend

A multi-targeted approach to suppress tumor-promoting inflammation

Cancers harbor significant genetic heterogeneity and patterns of relapse following many therapies are due to evolved resistance to treatment. While efforts have been made to combine targeted therapies, significant levels of toxicity have stymied efforts to effectively treat cancer with multi-drug combinations using currently approved therapeutics. We discuss the relationship between tumor-promoting inflammation and cancer as part of a larger effort to develop a broad-spectrum therapeutic approach aimed at a wide range of targets to address this heterogeneity. Specifically, macrophage migration inhibitory factor, cyclooxygenase-2, transcription factor nuclear factor-κB, tumor necrosis factor alpha, inducible nitric oxide synthase, protein kinase B, and CXC chemokines are reviewed as important antiinflammatory targets while curcumin, resveratrol, epigallocatechin gallate, genistein, lycopene, and anthocyanins are reviewed as low-cost, low toxicity means by which these targets might all be reached simultaneously. Future translational work will need to assess the resulting synergies of rationally designed antiinflammatory mixtures (employing low-toxicity constituents), and then combine this with similar approaches targeting the most important pathways across the range of cancer hallmark phenotypes

Dynamics of Anti-S IgG Antibodies Titers after the Second Dose of COVID-19 Vaccines in the Manual and Craft Worker Population of Qatar

There is limited seroepidemiological evidence on the magnitude and long-term durability of antibody titers of mRNA and non-mRNA vaccines in the Qatari population. This study was conducted to generate evidence on long-term anti-S IgG antibody titers and their dynamics in individuals who have completed a primary COVID-19 vaccination schedule. A total of 300 male participants who received any of the following vaccines BNT162b2/Comirnaty, mRNA-1273, ChAdOx1-S/Covishield, COVID-19 Vaccine Janssen/Johnson, or BBIBP-CorV or Covaxin were enrolled in our study. All sera samples were tested by chemiluminescent microparticle immunoassay (CMIA) for the quantitative determination of IgG antibodies to SARS-CoV-2, receptor-binding domain (RBD) of the S1 subunit of the spike protein of SARS-CoV-2. Antibodies against SARS-CoV-2 nucleocapsid (SARS-CoV-2 N-protein IgG) were also determined. Kaplan–Meier survival curves were used to compare the time from the last dose of the primary vaccination schedule to the time by which anti-S IgG antibody titers fell into the lowest quartile (range of values collected) for the mRNA and non-mRNA vaccines. Participants vaccinated with mRNA vaccines had higher median anti-S IgG antibody titers. Participants vaccinated with the mRNA-1273 vaccine had the highest median anti-S-antibody level of 13,720.9 AU/mL (IQR 6426.5 to 30,185.6 AU/mL) followed by BNT162b2 (median, 7570.9 AU/mL; IQR, 3757.9 to 16,577.4 AU/mL); while the median anti-S antibody titer for non-mRNA vaccinated participants was 3759.7 AU/mL (IQR, 2059.7–5693.5 AU/mL). The median time to reach the lowest quartile was 3.53 months (IQR, 2.2–4.5 months) and 7.63 months (IQR, 6.3–8.4 months) for the non-mRNA vaccine recipients and Pfizer vaccine recipients, respectively. However, more than 50% of the Moderna vaccine recipients did not reach the lowest quartile by the end of the follow-up period. This evidence on anti-S IgG antibody titers should be considered for informing decisions on the durability of the neutralizing activity and thus protection against infection after the full course of primary vaccination in individuals receiving different type (mRNA verus non-mRNA) vaccines and those with natural infection.The World Health Organization (WHO) - grant number [2021/1183356-0]

Détermination des répertoires d'effecteurs de type III chez Xanthomonas spp. et analyse de leur rôle dans la spécificité d'hôte

Le genre Xanthomonas est constitué de 27 espèces bactériennes toutes associées aux plantes. Chez les Xanthomonas, comme chez de nombreuses bactéries phytopathogènes, l'adaptation à l'hôte est très étroite et est désignée sous le terme "pathovar". Un pathovar regroupe les souches responsables d'un même type de symptômes sur une même gamme d'hôtes. Notre hypothèse de base est que la spécificité d'hôte résulte de la confrontation entre un répertoire de gênes de colonisation de la bactérie et un répertoire de gênes de défense de la plante. Les gênes bactériens candidats sont les gênes codant les effecteurs de type III (ET3s) puisqu'ils peuvent élargir la gamme d'hôte des souches en supprimant les défenses de la plante, ou bien la restreindre lorsqu'ils sont reconnus par la plante...The genus Xanthomonas comprises 27 plant-associated bacterial species. As for many plant pathogenic bacteria, host specialisation is very high for bacteria belonging to the genus Xanthomonas, and numerous pathovars were defined in each species of the genus. A pathovar is a subspecific division that groups all bacterial strains that cause the same symptoms on the same plant host range. Our hypothesis is that host specificity would result from the interaction between repertoires of bacterial virulence genes and repertoires of genes involved in host defences. As bacterial candidate genes, we have chosen type III effectors (T3Es) since they may enlarge the host range of the strains of a given bacterium by suppressing host defences, or narrow the host range when one of them is specifically recognized by the plant...ANGERS-BU Lettres et Sciences (490072106) / SudocSudocFranceF

Chimie de l'isocyanate de chlorosulfonyle et applications aux biomolécules (A-Peptides latents, synthèse, structure et réactivité. B-N-hydroxylsulfamides analogues de l'hydroxylurée)

MONTPELLIER-BU Sciences (341722106) / SudocSudocFranceF

Qualitative And Quantitative Assessment Of Drained Water From Urban Ground-Water

Although the groundwater table in the State of Qatar peninsula is reducing, there is a persistent increasing level of groundwater in some areas in Doha city. This increasing tendency could be attributed to the topography of the area, geological structure, rapid urbanization, increase in water consumption, uncontrolled irrigation of farms and green areas as well as the absence of storm-water drainage system. To lower the groundwater table, a drainage system has been laid through Rayan and Wadi Musheirib which are the worst affected areas. This system drains away the groundwater as well as the stormwater to the Arabian Gulf. A qualitative and quantitative monitoring program was initiated in order to evaluate the possibility of utilizing this drained water. The results obtained indicate that the drainage water could be used for irrigating certain types of trees