313 research outputs found
Determining of the University Freshmen Studentsâ Misconceptions and Alternative Conceptions about Mitosis and Meiosis
- Publication venue
- 'Elsevier BV'
- Publication date
- 31/12/2012
- Field of study
AbstractThe purpose of our study is to determine the misconceptions and inadequate information which the university freshmen studentsâ held about mitosis and meiosis. We majored mostly on the numbers of chromosome potential and the DNA amount in our questions. In addition we wanted our students to interpret their past information about the subject. The results of our qualitative analyses show that students reword interphase as preparatory period but they donât recognize what happens in this period, precisely. Also, they donât explain DNA, chromosome and gene concepts. And they donât precisely recognize the importance of mitosis and meiosis for life
Effects of Urtica dioica on hepatic ischemiaâreperfusion injury in rats
- Publication venue
- Hospital das ClĂnicas da Faculdade de Medicina da Universidade de SĂŁo Paulo
- Publication date
- 01/01/2010
- Field of study
OBJECTIVES: To evaluate the effects of Urtica dioica on hepatic ischemia-reperfusion injury. METHODS: Thirty adult male Wistar albino rats were divided into three groups: sham group (group 1), control group (group 2), and Urtica dioica group (group 3). All the rats were exposed to hepatic ischemia for 60 min, followed by 60 min of reperfusion. In group 2, a total of 2 ml/kg 0.9% saline solution was given intraperitoneally. In group 3, a total of 2 ml/kg Urtica dioica was given intraperitoneally. At the end of the procedure, liver tissue and blood samples were taken from all rats. Serum aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, ceruloplasmin, catalase, paraoxonase, arylesterase, and lipid hydroperoxide levels were measured. Liver tissue histopathologies were also evaluated by light microscopy. RESULTS: Serum aspartate aminotransferase, alanine aminotransferase and lactate dehydrogenase levels were significantly higher in group 2 than in group 1, and significantly lower in group 3 than in group 2. Also, group 2 had higher serum lipid hydroperoxides and ceruloplasmin levels but lower catalase, paraoxonase, and arylesterase levels than group 1. In group 3, serum lipid hydroperoxides and ceruloplasmin levels were significantly lower, and catalase, paraoxonase, and arylesterase levels were higher than those in group 2. Histopathological examination showed that liver tissue damage was significantly decreased in group 3 compared with group 2. CONCLUSIONS: Urtica dioica has a protective effect on the liver in hepatic ischemia-reperfusion-injured rats
Optimally Controlling the Timing of Energy Transfer in Elastic Joints: Experimental Validation of the Bi-Stiffness Actuation Concept
- Author
- Publication venue
- Publication date
- 14/09/2023
- Field of study
Elastic actuation taps into elastic elements' energy storage for dynamic
motions beyond rigid actuation. While Series Elastic Actuators (SEA) and
Variable Stiffness Actuators (VSA) are highly sophisticated, they do not fully
provide control over energy transfer timing. To overcome this problem on the
basic system level, the Bi-Stiffness Actuation (BSA) concept was recently
proposed. Theoretically, it allows for full link decoupling, while
simultaneously being able to lock the spring in the drive train via a
switch-and-hold mechanism. Thus, the user would be in full control of the
potential energy storage and release timing. In this work, we introduce an
initial proof-of-concept of Bi-Stiffness-Actuation in the form of a 1-DoF
physical prototype, which is implemented using a modular testbed. We present a
hybrid system model, as well as the mechatronic implementation of the actuator.
We corroborate the feasibility of the concept by conducting a series of
hardware experiments using an open-loop control signal obtained by trajectory
optimization. Here, we compare the performance of the prototype with a
comparable SEA implementation. We show that BSA outperforms SEA 1) in terms of
maximum velocity at low final times and 2) in terms of the movement strategy
itself: The clutch mechanism allows the BSA to generate consistent launch
sequences while the SEA has to rely on lengthy and possibly dangerous
oscillatory swing-up motions. Furthermore, we demonstrate that providing full
control authority over the energy transfer timing and link decoupling allows
the user to synchronously release both elastic joint and gravitational energy.
This facilitates the optimal exploitation of elastic and gravitational
potentials in a synergistic manner.Comment: 8 pages, 9 figures. Submitted to IEEE Robotics and Automation Letter
Role of serum organic solute transporter alpha/beta and sodium taurocholate cotransporting polypeptide in intrahepatic cholestasis of pregnancy
- Publication venue
- 'VM Media SP. zo.o VM Group SK'
- Publication date
- 09/09/2016
- Field of study
Objectives: This study aimed to assess the role of OST-α, OST-ÎČ and NTCP in patients with ICP, with a view to determine patients with severe prognosis and to minimize adverse fetal outcomes.
Material and methods: Sixty-nine pregnant women diagnosed with ICP and 50 healthy women were included the study. Serum OST-α, OST-ÎČ and NTCP were measured using ELISA kits.
Results: The median OST-α levels were 176.3 pg/mL in women with ICP and 201 pg/mL in healthy subjects (p = 0.205). The median OST-ÎČ levels were found to be 51.17 pg/mL in patients with ICP and 40.9 pg/mL in controls (p = 0.033). Median NTCP levels were 519.7 ng/mL in the ICP group and 483.3 ng/mL in healthy women (p = 0.051).
Conclusions: This is the first study to evaluate serum levels of OST-α, OST-ÎČ and NTCP in patients with ICP. It is likely that OST-α, OST-ÎČ and NTCP contribute to the etiopathogenesis of ICP. Serum OST-α and OST-ÎČ levels can be used as diagnostic and monitoring markers of ICP, and the inhibition of these molecules could provide therapeutic benefit in ICP by reducing the circulation of enterohepatic bile acids
Prevention of Pulmonary Complications of Pneumoperitoneum in Rats
- Author
- A Dinckan
- A Nickkholgh
- A Uzunkoy
- Abdulkadir Iskender
- Ayhan Saritas
- Banu Karapolat
- C Kuntz
- CN Gutt
- DB Safran
- ES Erden
- H TĂŒrĂŒt
- Hayati Kandis
- Ismet Ozaydin
- KL Dechant
- L Tamer
- M Calikoglu
- M Moretti
- M Pross
- M Quintel
- M Sare
- M Sirmali
- Mehmet Yasar
- P Ypsilantis
- RW Dal Negro
- RW Dal Negro
- RW Dal Negro
- S Yilmaz
- Sami Karapolat
- Suat Gezer
- Talha Dumlu
- Umran Yildirim
- V Nesek-Adam
- Publication venue
- BioMed Central
- Publication date
- 01/01/2011
- Field of study
Why Are Outcomes Different for Registry Patients Enrolled Prospectively and Retrospectively? Insights from the Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF).
- Author
- A'Court C.
- Aaroe H.
- Abd El-Aziz A.
- Abdalla Saad J.
- Abdel-Qader M.
- Abdelrahman H.
- Abdul A.
- Abe M. (Masahiko)
- Abe M. (Masatake)
- Abe M. (Mitsunori)
- Abe S.
- Abe Y.
- Abhayaratna W.
- Abou Seif S. K.
- Abraham S.
- Abu-Mahfouz M.
- Abushal S.
- Accetta Gabriele
- Accogli M.
- Adachi S.
- Adachi S. (Sen)
- Adachi S. (Susumu)
- Adachi T.
- Adak D.
- Adriaansen H.
- Agakhanyan A.
- Agata J.
- Ageta M.
- Aggarwala A.
- Agliardi P.
- Agnelli G.
- Agnelli Giancarlo
- Agrawal A.
- Aguilar J.
- Ahbeck E.
- Ahlmark H.
- Ahmad K.
- Ahmad N.
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- Ahmed W.
- Ahn J. J.
- Ahuad Guerrero R. A.
- Ainsworth P.
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- Al Mahmeed W.
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- Alpay D.
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- Wutthimanop A.
- Xhaet O.
- Xie Q.
- Xiong L. G.
- Xu R. Y.
- Xue L.
- Yagensky A.
- Yakupov E.
- Yamada T.
- Yamagishi T.
- Yamaguchi H.
- Yamamoto K.
- Yamamoto K. (Kenichi)
- Yamamoto K. (Kentaro)
- Yamamoto K. (Kunihiko)
- Yamamoto T.
- Yamasawa M.
- Yamaura M.
- Yamazoe M.
- Yan X. W.
- Yang J. S.
- Yang L. L.
- Yang P.
- Yang Q.
- Yang Y. J.
- Yang Z. M.
- Yap S. Y.
- Yasui K.
- Yawila S.
- Ye S.
- Ye Y.
- Yeo C.
- Yeter E.
- Yildirim E.
- Yildirim R.
- Yilmaz F.
- Yilmaz M. B.
- Yilmaz O.
- Yim K. H.
- Yin Y. H.
- Yokota N.
- Yokoyama Y.
- Yong R.
- Yoo K. M.
- Yoon E. J.
- Yoon J. H.
- Yorgun H.
- Yoshida H.
- Yoshida K.
- Yoshida T. (Tetsuro)
- Yoshida T. (Tomoki)
- Yoshimura A.
- Yoshizawa N.
- Yousef G.
- Yu H. Y.
- Yu J. H.
- Yu T.
- Yuksekdag V
- Yun S. Y.
- Yunis M. E.
- Zaatout E.
- Zaidi S. M. A.
- Zaitsu R.
- Zak J.
- Zakutynska-Kowalczyk K.
- Zaluska R.
- Zaman K.
- Zanolin D.
- Zapata G.
- Zateyshchikov D.
- Zateyshchikova A.
- Zauzig H-D
- Zauzig H.
- Zecca C.
- Zemlianskaia O.
- Zhai H.
- Zhan Q.
- Zhang G. S.
- Zhang H. Q.
- Zhang Q.
- Zhang R.
- Zhang Y.
- Zhao R. P.
- Zhao Y. S.
- Zheng W. Y.
- Zhirov I
- Zhou B.
- Zhou Z. H.
- Zhu X. Y.
- Zhuravleva E.
- Zhurba S.
- Zidek M.
- Zidkova E.
- Ziefle S.
- Zika J.
- Zillo M.
- Zimmett L.
- Zimny H-H
- Zincke S.
- Zinka E.
- Zotova I
- Zrazhevskiy K.
- Zubeeva G.
- Zuber M.
- Zurbrigk F. J.
- Zutz S.
- Zyczynska-Szmon M.
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2018
- Field of study
Background: Retrospective and prospective observational studies are designed to reflect real-world evidence on clinical practice, but can yield conflicting results. The GARFIELD-AF Registry includes both methods of enrolment and allows analysis of differences in patient characteristics and outcomes that may result. Methods and Results: Patients with atrial fibrillation (AF) and â„1 risk factor for stroke at diagnosis of AF were recruited either retrospectively (nâ=â5069) or prospectively (nâ=â5501) from 19 countries and then followed prospectively. The retrospectively enrolled cohort comprised patients with established AF (for a least 6, and up to 24 months before enrolment), who were identified retrospectively (and baseline and partial follow-up data were collected from the emedical records) and then followed prospectively between 0-18 months (such that the total time of follow-up was 24 months; data collection Dec-2009 and Oct-2010). In the prospectively enrolled cohort, patients with newly diagnosed AF (â€6 weeks after diagnosis) were recruited between Mar-2010 and Oct-2011 and were followed for 24 months after enrolment. Differences between the cohorts were observed in clinical characteristics, including type of AF, stroke prevention strategies, and event rates. More patients in the retrospectively identified cohort received vitamin K antagonists (62.1% vs. 53.2%) and fewer received non-vitamin K oral anticoagulants (1.8% vs . 4.2%). All-cause mortality rates per 100 person-years during the prospective follow-up (starting the first study visit up to 1 year) were significantly lower in the retrospective than prospectively identified cohort (3.04 [95% CI 2.51 to 3.67] vs . 4.05 [95% CI 3.53 to 4.63]; pâ=â0.016). Conclusions: Interpretations of data from registries that aim to evaluate the characteristics and outcomes of patients with AF must take account of differences in registry design and the impact of recall bias and survivorship bias that is incurred with retrospective enrolment. Clinical Trial Registration: - URL: http://www.clinicaltrials.gov . Unique identifier for GARFIELD-AF (NCT01090362)
Search for dark matter produced in association with bottom or top quarks in âs = 13 TeV pp collisions with the ATLAS detector
- Author
- Aaboud Morad
- Aad Georges
- Abbott Brad
- Abdinov Ovsat
- Abeloos Baptiste
- Abidi Syed
- AbouZeid Ossama
- Abraham Nicola
- Abramowicz Halina
- Abreu Henso
- Abreu Ricardo
- Abulaiti Yiming
- Acharya Bobby
- Adachi Shunsuke
- Adamczyk Leszek
- Adelman Jahred
- Adersberger Michael
- Adye Tim
- Affolder Tony
- Afik Yoav
- Agatonovic-Jovin Tatjana
- Agheorghiesei Catalin
- Aguilar-Saavedra Juan
- Ahlen Steven
- Ahmadov Faig
- Aielli Giulio
- Akatsuka Shunichi
- Akerstedt Henrik
- Akilli Ece
- Akimov Andrei
- Alberghi Gian
- Albert Justin
- Albicocco Pietro
- Alconada Verzini Maria
- Alderweireldt Sara
- Aleksa Martin
- Aleksandrov Igor
- Alexa Calin
- Alexander Gideon
- Alexopoulos Theodoros
- Alhroob Muhammad
- Ali Babar
- Aliev Malik
- Alimonti Gianluca
- Alison John
- Alkire Steven
- Allbrooke Benedict
- Allen Benjamin
- Allport Phillip
- Aloisio Alberto
- Alonso Alejandro
- Alonso Francisco
- Alpigiani Cristiano
- Alshehri Azzah
- Alstaty Mahmoud
- Alvarez Gonzalez Barbara
- Alviggi Mariagrazia
- Amadio Brian
- Amaral Coutinho Yara
- Amelung Christoph
- Amidei Dante
- Amor Dos Santos Susana
- Amoroso Simone
- Anastopoulos Christos
- Ancu Lucian
- Andari Nansi
- Andeen Timothy
- Anders Christoph
- Anders John
- Anderson Kelby
- Andreazza Attilio
- Andrei George
- Angelidakis Stylianos
- Angelozzi Ivan
- Angerami Aaron
- Anisenkov Alexey
- Anjos Nuno
- Annovi Alberto
- Antel Claire
- Antonelli Mario
- Antonov Alexey
- Antrim Daniel
- Anulli Fabio
- Aoki Masato
- Aperio Bella Ludovica
- Arabidze Giorgi
- Arai Yasuo
- Araque Juan
- Araujo Ferraz Victor
- Arce Ayana
- Ardell Rose
- Arduh Francisco
- Arguin Jean-Francois
- Argyropoulos Spyridon
- Arik Metin
- Armbruster Aaron
- Armitage Lewis
- Arnaez Olivier
- Arnold Hannah
- Arratia Miguel
- Arslan Ozan
- Artamonov Andrei
- Artoni Giacomo
- Artz Sebastian
- Asai Shoji
- Asbah Nedaa
- Ashkenazi Adi
- Asquith Lily
- Assamagan Ketevi
- Astalos Robert
- Atkinson Markus
- Atlay Naim
- Augsten Kamil
- Avolio Giuseppe
- Axen Bradley
- Ayoub Mohamad
- Azuelos Georges
- Baas Alessandra
- Baca Matthew
- Bachacou Henri
- Bachas Konstantinos
- Backes Moritz
- Bagnaia Paolo
- Bahmani Marzieh
- Bahrasemani Sina
- Baines John
- Bajic Milena
- Baker Oliver
- Bakker Pepijn
- Baldin Evgenii
- Balek Petr
- Balli Fabrice
- Balunas William
- Banas Elzbieta
- Bandyopadhyay Anjishnu
- Banerjee Swagato
- Bannoura Arwa
- Barak Liron
- Barberio Elisabetta
- Barberis Dario
- Barbero Marlon
- Barillari Teresa
- Barisits Martin-Stefan
- Barkeloo Jason
- Barklow Timothy
- Barlow Nick
- Barnes Sarah
- Barnett Bruce
- Barnett Michael
- Barnovska-Blenessy Zuzana
- Baroncelli Antonio
- Barone Gaetano
- Barr Alan
- Barranco Navarro Laura
- Barreiro GuimarĂŁes da Costa JoĂŁo
- Barreiro Fernando
- Barros Vale Maria
- Bartoldus Rainer
- Barton Adam
- Bartos Pavol
- Basalaev Artem
- Bassalat Ahmed
- Bates Richard
- Batista Santiago
- Batley Richard
- Battaglia Marco
- Bauce Matteo
- Bauer Florian
- Bawa Harinder
- Beacham James
- Beattie Michael
- Beau Tristan
- Beauchemin Pierre-Hugues
- Bechtle Philip
- Beck Hans~Peter
- Beck Helge
- Becker Kathrin
- Becker Maurice
- Becot Cyril
- Beddall Andrew
- Beddall Ayda
- Bednyakov Vadim
- Bedognetti Matteo
- Bee Christopher
- Beermann Thomas
- Begalli Marcia
- Begel Michael
- Behr Janna
- Bell Andrew
- Bella Gideon
- Bellagamba Lorenzo
- Bellerive Alain
- Bellomo Massimiliano
- Belotskiy Konstantin
- Beltramello Olga
- Belyaev Nikita
- Benary Odette
- Benchekroun Driss
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- Benhammou Yan
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- Benitez Jose
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- Benoit Mathieu
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- Bentvelsen Stan
- Beresford Lydia
- Beretta Matteo
- Berge David
- Bergeaas Kuutmann Elin
- Berger Nicolas
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- Berlendis Simon
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- Bessidskaia Bylund Olga
- Bessner Martin
- Besson Nathalie
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- Bethke Siegfried
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- Bevan Adrian
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- Billoud Thomas
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- Bjergaard David
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- Blue Andrew
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- Bobbink Gerjan
- Bobrovnikov Victor
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- Bocci Andrea
- Bock Christopher
- Boehler Michael
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- Bogavac Danijela
- Bogdanchikov Alexander
- Bohm Christian
- Boisvert Veronique
- Bokan Petar
- Bold Tomasz
- Boldyrev Alexey
- Bolz Arthur
- Bomben Marco
- Bona Marcella
- Boonekamp Maarten
- Borisov Anatoly
- Borissov Guennadi
- Bortfeldt Jonathan
- Bortoletto Daniela
- Bortolotto Valerio
- Boscherini Davide
- Bosman Martine
- Bossio Sola Jonathan
- Boudreau Joseph
- Bouhova-Thacker Evelina
- Boumediene Djamel
- Bourdarios Claire
- Boutle Sarah
- Boveia Antonio
- Boyd James
- Boyko Igor
- Bozson Adam
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- Brandt Andrew
- Brandt Gerhard
- Brandt Oleg
- Braren Frued
- Bratzler Uwe
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- Brendlinger Kurt
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- Briglin Daniel
- Bristow Timothy
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- Britzger Daniel
- Brochu Frederic
- Brock Ian
- Brock Raymond
- Brooijmans Gustaaf
- Brooks Timothy
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- Brost Elizabeth
- Broughton James
- Bruckman de Renstrom Pawel
- Bruncko Dusan
- Bruni Alessia
- Bruni Graziano
- Bruni Lucrezia
- Bruno Salvatore
- Brunt Benjamin
- Bruschi Marco
- Bruscino Nello
- Bryant Patrick
- Bryngemark Lene
- Buanes Trygve
- Buat Quentin
- Buchholz Peter
- Buckley Andrew
- Budagov Ioulian
- Buehrer Felix
- Bugge Magnar
- Bulekov Oleg
- Bullock Daniel
- Burch Tyler
- Burdin Sergey
- Burgard Carsten
- Burger Angela
- Burghgrave Blake
- Burka Klaudia
- Burke Stephen
- Burmeister Ingo
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- Buttar Craig
- Butterworth Jonathan
- Butti Pierfrancesco
- Buttinger William
- Buzatu Adrian
- Buzykaev Aleksey
- BĂŒscher Daniel
- BĂŒscher Volker
- C-Q Changqiao
- Cabrera UrbĂĄn Susana
- Caforio Davide
- Cai Huacheng
- Cairo Valentina
- Cakir Orhan
- Calace Noemi
- Calafiura Paolo
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- Calderini Giovanni
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- Callea Giuseppe
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- Calvente Lopez Sergio
- Calvet David
- Calvet Samuel
- Calvet Thomas
- Camacho Toro Reina
- Camarda Stefano
- Camarri Paolo
- Cameron David
- Caminal Armadans Roger
- Camincher Clement
- Campana Simone
- Campanelli Mario
- Camplani Alessandra
- Campoverde Angel
- Canale Vincenzo
- Cano Bret Marc
- Cantero Josu
- Cao Tingting
- Capeans Garrido Maria
- Caprini Irinel
- Caprini Mihai
- Capua Marcella
- Carbone Ryne
- Cardarelli Roberto
- Cardillo Fabio
- Carli Ina
- Carli Tancredi
- Carlino Gianpaolo
- Carlson Benjamin
- Carminati Leonardo
- Carney Rebecca
- Caron Sascha
- Carquin Edson
- Carrillo-Montoya German
- CarrĂĄ Sonia
- Casadei Diego
- Casado Maria
- Casha Albert
- Casolino Mirkoantonio
- Casper David
- Castelijn Remco
- Castillo Gimenez Victoria
- Castro Nuno
- Catinaccio Andrea
- Catmore James
- Cattai Ariella
- Caudron Julien
- Cavaliere Viviana
- Cavallaro Emanuele
- Cavalli Donatella
- Cavalli-Sforza Matteo
- Cavasinni Vincenzo
- Celebi Emre
- Ceradini Filippo
- Cerda Alberich Leonor
- Cerri Alessandro
- Cerrito Lucio
- Cerutti Fabio
- Cervelli Alberto
- Cetin Serkant
- Chafaq Aziz
- Chakraborty Dhiman
- Chan Stephen
- Chan Wing
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- Chang Philip
- Chapman John
- Charlton Dave
- Chau Chav
- Chavez Barajas Carlos
- Che Siinn
- Cheatham Susan
- Chegwidden Andrew
- Chekanov Sergei
- Chekulaev Sergey
- Chelkov Gueorgui
- Chelstowska Magda
- Chen Cheng
- Chen Chunhui
- Chen Hucheng
- Chen Jing
- Chen Shenjian
- Chen Shion
- Chen Xin
- Chen Ye
- Cheng Hok
- Cheng Huajie
- Cheplakov Alexander
- Cheremushkina Evgeniya
- Cherkaoui El Moursli Rajaa
- Cheu Elliott
- Cheung Kingman
- Chevalier Laurent
- Chiarella Vitaliano
- Chiarelli Giorgio
- Chiodini Gabriele
- Chisholm Andrew
- Chitan Adrian
- Chiu Yu
- Chizhov Mihail
- Choi Kyungeon
- Chomont Arthur
- Chouridou Sofia
- Chow Yun
- Christodoulou Valentinos
- Chu Ming
- Chudoba Jiri
- Chuinard Annabelle
- Chwastowski Janusz
- Chytka Ladislav
- Ciftci Abbas
- Cinca Diane
- Cindro Vladimir
- Cioara Irina
- Ciocio Alessandra
- Cirotto Francesco
- Citron Zvi
- Citterio Mauro
- Ciubancan Mihai
- Clark Allan
- Clark Brian
- Clark Michael
- Clark Philip
- Clarke Robert
- Clement Christophe
- Coadou Yann
- Cobal Marina
- Coccaro Andrea
- Cochran James
- Colasurdo Luca
- Cole Brian
- Colijn Auke-Pieter
- Collot Johann
- Colombo Tommaso
- Conde Muiño Patricia
- Coniavitis Elias
- Connell Simon
- Connelly Ian
- Constantinescu Serban
- Conti Geraldine
- Conventi Francesco
- Cooke Mark
- Cooper-Sarkar Amanda
- Cormier Felix
- Cormier Kyle
- Corradi Massimo
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- Cortes-Gonzalez Arely
- Costa Giuseppe
- Costa MarĂa
- Costanzo Davide
- Cottin Giovanna
- Cowan Glen
- Cox Brian
- Cranmer Kyle
- Crawley Samuel
- Creager Rachael
- Cree Graham
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- Cribbs Wayne
- Cristinziani Markus
- Croft Vince
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- Crépé-Renaudin Sabine
- Cueto Ana
- Cuhadar Donszelmann Tulay
- Cukierman Aviv
- Cummings Jane
- Curatolo Maria
- Czekierda Sabina
- Czodrowski Patrick
- CĂșth Jakub
- D'amen Gabriele
- D'Auria Saverio
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- D'Onofrio Monica
- Da Cunha Sargedas De Sousa Mario
- Da Via Cinzia
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- Dado Tomas
- Dai Tiesheng
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- Dallaire Frederick
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- Dam Mogens
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- de Asmundis Riccardo
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- De Kaushik
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- della Volpe Domenico
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- Drechsler Eric
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- Eckardt Christoph
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- Elliot Alison
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- Ezzi Mohammed
- Fabbri Federica
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- Zanzi Daniele
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- Zemaityte Gabija
- Zemla Andrzej
- Zeng Jian
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- Zhang Ruiqi
- Zhang Xueyao
- Zhang Yu
- Zhang Zhiqing
- Zhao Xiandong
- Zhao Yongke
- Zhao Zhengguo
- Zhemchugov Alexey
- Zhou Bing
- Zhou Chen
- Zhou Li
- Zhou Maosen
- Zhou Mingliang
- Zhou Ning
- Zhou You
- Zhu Cheng
- Zhu Hongbo
- Zhu Junjie
- Zhu Yingchun
- Zhuang Xuai
- Zhukov Konstantin
- Zibell Andre
- Zieminska Daria
- Zimine Nikolai
- Zimmermann Christoph
- Zimmermann Stephanie
- Zinonos Zinonas
- Zinser Markus
- Ziolkowski Michael
- Zobernig Georg
- Zoccoli Antonio
- Zou Rui
- zur Nedden Martin
- Zwalinski Lukasz
- Ă kesson Torsten
- Ć filigoj Tina
- ĆœeniĆĄ Tibor
- ĆœivkoviÄ Lidija
- Îlvarez Piqueras DamiĂĄn
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fbâ1 of protonâproton collision data recorded by the ATLAS experiment at âs = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements
Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries
- Author
- Aamir Faiqa Binte
- Aamir Syed Roohan
- Ababneh Adnan
- Abbal Muhammad Anas
- Abbas Ahmed M
- Abbas Mostafa
- Abd-Albain Montasir A
- Abdalei Abdulwahab
- Abdalla Ahmed
- Abdalla Ahmed Yassir
- Abdalla Mohamed Galal Ali
- Abdalla Zainab
- Abdallah Mohamed M
- Abdalmahmoud Noon Ezzeldien
- Abdalsadeg Rowa
- Abdelaal Ahmed M
- Abdelbagi Alnazeer Y
- Abdelbaky Mostafa
- Abdelbaset Doaa
- AbdElbaset Esraa
- Abdelbast Menhag
- Abdelfatah Mohammed Abdelnasser
- Abdelgawad Samia
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- Wright Deborah
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- Wu Hongyi
- Wycliff Daniel
- Xiao Haotian
- Xie Maria
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- Xu William
- Xu William
- Xu William
- Yaghmour Jamal
- Yahya Bilal Shuaibu
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- Yildirim Yasemin
- Yildiz Ahmet
- Yıldız Berkay
- Yilmaz Hakan
- Yin Chonghao
- Ying Geoffrey
- Yodkitydomying Chatnapa
- Yong Nathania
- Yoon Si Woo
- You Ha Seong
- Young Simon
- Young Stevie
- Younus Khadijah
- Yousif Fatima Imad
- Yousri Mohamed
- Youssef Ahmed A
- Youssef Arkan
- Yu Hoi Hang
- Yu Victor
- Yuan Grace
- Yue Bosco
- Yue Tiffany
- Yunos Mohamed Haseef Mohamed
- Yusuf Stephen
- Yuzgec Ayse Nilufer
- Zachomitros Fotios
- Zaed Moahmed
- Zafar Fatima
- Zaghloul Ahmed
- Zaheer Adil
- Zaidi Faseeh
- Zain Ahmad
- Zakaria Ahmed
- Zakaria Andee Dzulkarnaen
- Zakaria Mohd Zaim
- Zalloum Jihad
- Zamanbandhon Bushra
- Zambon Mattia
- Zapsalis Konstantinos
- Zargar Kamran
- Zarzour Mohamed A
- Zeng Raymond
- Zeng Raymond
- Zengin Kagan
- Zertuche Juventino Tadeo Guerrero
- Zhang Caitlin
- Zhang Edward
- Zhang Shane
- Zhang Yichi
- Zhao Hailin
- Zheng Helen
- Zhou Karen
- Zhou Yida
- Ziergiebel Felix
- Zou Peishan
- Zuylekom Kate Van
- Zuylekom Katie Van
- Zwain Yasir Adnan
- Zyul'korneeva Sof'ya
- âAladna âAbdallah
- âAljoumaa âAbdullah
- âNawfal âHamdi
- âNiazi âAmmar
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely
Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.
- Author
- A. Abd El-Aziz
- A. Abdul
- A. Agakhanyan
- A. Aggarwala
- A. Agrawal
- A. Al Mulla
- A. Al Naeemi
- A. Alfieri
- A. Ali
- A. Altun
- A. Alvarez D'Amelio
- A. Andersson
- A. Argena
- A. Austria
- A. Aydinlar
- A. Babyesiza
- A. Barai
- A. Barreau
- A. Barszcz
- A. Bartes
- A. Bazzoni Ruiz
- A. Beattie
- A. Bianchi
- A. Biernacka
- A. Black
- A. Blenkhorn
- A. Branjovich Tijuan
- A. Bremmelgaard
- A. Brown
- A. Browne
- A. Capucci
- A. Caspar
- A. Catanchin
- A. Chmielowski
- A. Choi
- A. Cieszynska
- A. Conde Y Bolado
- A. Connelly
- A. Cortada Cabrera
- A. Davids
- A. De Blasio
- A. De Wolf
- A. Dickerson
- A. Domenech Borras
- A. Dumikyan
- A. Edin
- A. Egilsson
- A. El-Etreby
- A. Elbahry
- A. Elorriaga Madariaga
- A. Espallargas
- A. Ewert
- A. Fearon
- A. Fedorowsky
- A. Ferreira-Jardim
- A. Ferrer
- A. Filippi
- A. Fleck
- A. Flynn
- A. Forero
- A. Frankiewicz
- A. Fujisawa
- A. Gallagher
- A. Ganatra
- A. Gegenhuber
- A. Gieroba
- A. Gilliland
- A. Giombolini
- A. Gonzales Segovia
- A. Grande Ruiz
- A. Grau
- A. Grytzmann
- A. Gubanov
- A. Guerrero Molina
- A. Guinand
- A. Haideri
- A. Hajimirsadeghi
- A. HallarÄker
- A. Halpin
- A. Hay
- A. Heer
- A. Heyse
- A. Horak
- A. Hot-Bjelac
- A. Howitt
- A. Iglesias Garcia
- A. Ishihara
- A. Ivanov
- A. Iñiguez Romo
- A. Jackun-Podlesna
- A. Jaremczuk-Kaczmarczyk
- A. Jarzebowski
- A. Jefferies
- A. Jekthammer
- A. Jerzewski
- A. John Camm
- A. John Camm
- A. John Camm
- A. Jones
- A. Kaczmarzyk-Radka
- A. Karczmarczyk
- A. Katta
- A. Kemmel
- A. Khan
- A. Khokhlov
- A. Koch
- A. Kolesnikova
- A. Kolodzinska
- A. Komlo
- A. Konopka
- A. Kopf
- A. Krueger
- A. Krzesiak-Lodyga
- A. Lavoie
- A. Lawande
- A. Lee
- A. Lettenström
- A. Leyva RendĂłn
- A. Lindberg
- A. Lindh
- A. Lindourkova
- A. Lischka-Lindner
- A. Lo Buglio
- A. Lopes
- A. Lopez
- A. Lucassen
- A. Ludkova
- A. Lysek-Jozefowicz
- A. Mannermyr
- A. Manzanal Rey
- A. Mariani
- A. Markiewicz
- A. Marquand
- A. Martin Vila
- A. Martinelli
- A. Maselli
- A. Matoltsy
- A. Mauric
- A. Meirino
- A. Menezes Lorga Filho
- A. Merliss
- A. Metzgier-Gumiela
- A. Mielot
- A. Mirtl
- A. Miyashita
- A. Mizuno
- A. Mowafy
- A. Murray
- A. Naguib
- A. Nagy
- A. Nakagomi
- A. Nakata
- A. Navarro
- A. Negrete Palma
- A. Negri
- A. Niemirycz-Makurat
- A. Nowak
- A. Nygaard
- A. Ohanissian
- A. Ohlsson
- A. Olofsson
- A. Ortiz
- A. Osberg
- A. Ota
- A. Oto
- A. Ovsannikova
- A. Page
- A. Papp
- A. Parkhomenko
- A. Pawelska-Buczen
- A. Pedersen
- A. Phrommintikul
- A. Pinter
- A. Pizzini
- A. Plauskat
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- A. Taguchi
- A. Talkenberger
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- A. Thomson
- A. Tomasello
- A. Ushakov
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- Ajay K. Kakkar
- Ajay K. Kakkar
- Alex Parkhomenko
- Alex Spyropoulos
- Alexander G.G. Turpie
- Ali Oto
- Antonio Carlos Pereira Barretto
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- B.Y. Sayin
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- Bernard J. Gersh
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- J. Abdalla Saad
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- J. Aguilar
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- J. Goram
- J. Gunasegaram
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- J. Jankielewicz
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- Y. Wakasa
- Y. Ye
- Y. Yokoyama
- Y. Zhang
- Y.-I. Kim
- Y.H. Li
- Y.H. Sun
- Y.H. Yin
- Y.J. Yang
- Y.J. Yang
- Y.K. On
- Y.M. Chen
- Y.M. Lee
- Y.M. Sohn
- Y.R. Jeon
- Y.S. Oh
- Y.S. Son
- Y.S. Zhao
- Y.Y. Liu
- Ying Wang
- Yoichi Nakamura
- Yong Wang
- Yoshihisa Fujiura
- Yoshitake Fujiura
- Yuhei Shiga
- Yuichiro Nakamura
- Yukihiro Koretsune
- Yukio Shiga
- Z. Babjakova
- Z. Boda
- Z. Djaidani
- Z. Lajkowski
- Z. Laszlo
- Z. May
- Z. Monhart
- Z. Ongen
- Z. Radics
- Z.C. Lu
- Z.H. Zhou
- Z.M. Yang
- Publication venue
- Indian Heart J
- Publication date
- 01/01/2018
- Field of study
BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362
Improved risk stratification of patients with atrial fibrillation: an integrated GARFIELD-AF tool for the prediction of mortality, stroke and bleed in patients with and without anticoagulation.
- Author
- A'Court C.
- Aaroe H.
- Abdel-Qader M.
- Abdelrahman H.
- Abdul A.
- Abe M.
- Abe M.
- Abe M.
- Abe S.
- Abe Y.
- Abhayaratna W.
- Abraham S.
- Abu-Mahfouz M.
- Abushal S.
- Accogli M.
- Adachi S.
- Adachi S.
- Adachi S.
- Adachi T.
- Adak D.
- Adriaansen H.
- Agakhanyan A.
- Agata J.
- Ageta M.
- Aggarwala A.
- Agliardi P.
- Agnelli G.
- Agrawal A.
- Aguilar J.
- Ahbeck E.
- Ahlmark H.
- Ahmad K.
- Ahmad N.
- Ahmad S.
- Ahmed F.
- Ahmed W.
- Ahn J. J.
- Ainsworth P.
- Airaksinen J.
- Akahane K.
- Akiyama M.
- Aktas O.
- Akutsu M.
- Al Mahmeed W.
- Al Mulla A.
- Al Naeemi A.
- Al Omairi M.
- Al-Khalili F.
- Alaguibe E. D.
- Alban F.
- Alberts M.
- Alborough E.
- Aldegather J.
- Aleksandrova E.
- Alfaro T. A. A.
- Alfieri A.
- Ali A.
- Alia J. J. M.
- Alia P. M.
- Alkan D. U.
- Allasia B.
- Alonso C.
- Alonso C.
- Alonso L. F. I.
- Alpay D.
- Alsina R. C.
- Altun A.
- Alunni M.
- Alvarez D.
- Alvarez M.
- Alvarez M. R.
- Alzand B.
- Amano T.
- Amarenco P.
- Amaro M.
- Ambicka M.
- Ambrosino P.
- Ambrosio G.
- Amstutz D.
- An H. J.
- Andere N.
- Andersson A.
- Andersson L.
- Andersson L.
- Ando H.
- Ando S.
- Andrzejewski D.
- Angaran P.
- Angchaisuksiri P.
- Angel G.
- Anne W.
- Antonova P.
- Antonsen H.
- Aoki K.
- Aoyama T.
- Arabetti C.
- Arai H.
- Araminowicz J.
- Aras D.
- Aras F.
- Arasaki O.
- Araujo G. R.
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- Zaluska R.
- Zaman K.
- Zanolin D.
- Zapata G.
- Zateyshchikov D.
- Zateyshchikova A.
- Zauzig H.
- Zauzig H. -D.
- Zavala M. G. R.
- Zavaleta N. E.
- Zecca C.
- Zemlianskaia O.
- Zhai H.
- Zhan Q.
- Zhang G. S.
- Zhang H. Q.
- Zhang Q.
- Zhang R.
- Zhang Y.
- Zhao R. P.
- Zhao Y. S.
- Zheng W. Y.
- Zhirov I.
- Zhou B.
- Zhou Z. H.
- Zhu X. Y.
- Zhuravleva E.
- Zhurba S.
- Zidek M.
- Zidkova E.
- Ziefle S.
- Zika J.
- Zillo M.
- Zimmett L.
- Zimny H. -H.
- Zincke S.
- Zinka E.
- Zotova I.
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- Zubeeva G.
- Zuber M.
- Zurbrigk F. J.
- Zurita F. M.
- Zutz S.
- Zyczynska-Szmon M.
- Publication venue
- BMJ Open
- Publication date
- 01/01/2017
- Field of study
OBJECTIVES: To provide an accurate, web-based tool for stratifying patients with atrial fibrillation to facilitate decisions on the potential benefits/risks of anticoagulation, based on mortality, stroke and bleeding risks. DESIGN: The new tool was developed, using stepwise regression, for all and then applied to lower risk patients. C-statistics were compared with CHA2DS2-VASc using 30-fold cross-validation to control for overfitting. External validation was undertaken in an independent dataset, Outcome Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF). PARTICIPANTS: Data from 39 898 patients enrolled in the prospective GARFIELD-AF registry provided the basis for deriving and validating an integrated risk tool to predict stroke risk, mortality and bleeding risk. RESULTS: The discriminatory value of the GARFIELD-AF risk model was superior to CHA2DS2-VASc for patients with or without anticoagulation. C-statistics (95%âCI) for all-cause mortality, ischaemic stroke/systemic embolism and haemorrhagic stroke/major bleeding (treated patients) were: 0.77 (0.76 to 0.78), 0.69 (0.67 to 0.71) and 0.66 (0.62 to 0.69), respectively, for the GARFIELD-AF risk models, and 0.66 (0.64-0.67), 0.64 (0.61-0.66) and 0.64 (0.61-0.68), respectively, for CHA2DS2-VASc (or HAS-BLED for bleeding). In very low to low risk patients (CHA2DS2-VASc 0 or 1 (men) and 1 or 2 (women)), the CHA2DS2-VASc and HAS-BLED (for bleeding) scores offered weak discriminatory value for mortality, stroke/systemic embolism and major bleeding. C-statistics for the GARFIELD-AF risk tool were 0.69 (0.64 to 0.75), 0.65 (0.56 to 0.73) and 0.60 (0.47 to 0.73) for each end point, respectively, versus 0.50 (0.45 to 0.55), 0.59 (0.50 to 0.67) and 0.55 (0.53 to 0.56) for CHA2DS2-VASc (or HAS-BLED for bleeding). Upon validation in the ORBIT-AF population, C-statistics showed that the GARFIELD-AF risk tool was effective for predicting 1-year all-cause mortality using the full and simplified model for all-cause mortality: C-statistics 0.75 (0.73 to 0.77) and 0.75 (0.73 to 0.77), respectively, and for predicting for any stroke or systemic embolism over 1âyear, C-statistics 0.68 (0.62 to 0.74). CONCLUSIONS: Performance of the GARFIELD-AF risk tool was superior to CHA2DS2-VASc in predicting stroke and mortality and superior to HAS-BLED for bleeding, overall and in lower risk patients. The GARFIELD-AF tool has the potential for incorporation in routine electronic systems, and for the first time, permits simultaneous evaluation of ischaemic stroke, mortality and bleeding risks. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier for GARFIELD-AF (NCT01090362) and for ORBIT-AF (NCT01165710)
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