67 research outputs found
Boron isotope analysis of silicate glass with very low boron concentrations by secondary ion mass spectrometry
Author Posting. © The Author(s), 2014. This is the author's version of the work. It is posted here by permission of International Association of Geoanalysts for personal use, not for redistribution. The definitive version was published in Geostandards and Geoanalytical Research 39 (2015): 31-46, doi:10.1111/j.1751-908X.2014.00289.x.Here we present an improved method for the determination of the boron isotopic composition of volcanic glasses with boron concentrations of as low as 0.4–2.5 μg g−1, as is typical for mid-ocean ridge basalt glasses. The analyses were completed by secondary ion mass spectrometry using a Cameca 1280 large-radius ion microprobe. Transmission and stability of the instrument and analytical protocol were optimised, which led to an improvement of precision and reduction in surface contamination and analysis time compared with earlier studies. Accuracy, reproducibility (0.4–2.3‰, 2 RSD), measurement repeatability (2 RSE = 2.5–4.0‰ for a single spot with [B] = 1 μg g−1), matrix effects (≪ 0.5‰ among komatiitic, dacitic and rhyolitic glass), machine drift (no internal drift; long-term drift: ~ 0.1‰ hr−1), contamination (~ 3–8 ng g−1) and machine background (0.093 s−1) were quantified and their influence on samples with low B concentrations was determined. The newly developed set-up was capable of determining the B isotopic composition of basaltic glass with 1 μg g−1 B with a precision and accuracy of ± 1.5‰ (2 RSE) by completing 4–5 consecutive spot analyses with a spatial resolution of 30 μm × 30 μm. Samples with slightly higher concentrations (≥ 2.5 μg g−1) could be analysed with a precision of better than ± 2‰ (internal 2 RSE) with a single spot analysis, which took 32 min.This study was financially supported
by the NSF ocean sciences program (OCE grant 1232996 to Dorsey Wanless and HRM).2015-06-1
Accuracy and reproducibility of coral Sr/Ca SIMS timeseries in modern and fossil corals
© The Author(s), 2022. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Sayani, H., Cobb, K., Monteleone, B., & Bridges, H. Accuracy and reproducibility of coral Sr/Ca SIMS timeseries in modern and fossil corals. Geochemistry, Geophysics, Geosystems, 23(9), (2022): e2021GC010068, https://doi.org/10.1029/2021gc010068.Coral strontium-to-calcium ratios (Sr/Ca) provide quantitative estimates of past sea surface temperatures (SST) that allow for the reconstruction of changes in the mean state and climate variations, such as the El Nino-Southern Oscillation, through time. However, coral Sr/Ca ratios are highly susceptible to diagenesis, which can impart artifacts of 1–2°C that are typically on par with the tropical climate signals of interest. Microscale sampling via Secondary Ion Mass Spectrometry (SIMS) for the sampling of primary skeletal material in altered fossil corals, providing much-needed checks on fossil coral Sr/Ca-based paleotemperature estimates. In this study, we employ a set modern and fossil corals from Palmyra Atoll, in the central tropical Pacific, to quantify the accuracy and reproducibility of SIMS Sr/Ca analyses relative to bulk Sr/Ca analyses. In three overlapping modern coral samples, we reproduce bulk Sr/Ca estimates within ±0.3% (1σ). We demonstrate high fidelity between 3-month smoothed SIMS coral Sr/Ca timeseries and SST (R = −0.5 to −0.8; p < 0.5). For lightly-altered sections of a young fossil coral from the early-20th century, SIMS Sr/Ca timeseries reproduce bulk Sr/Ca timeseries, in line with our results from modern corals. Across a moderately-altered section of the same fossil coral, where diagenesis yields bulk Sr/Ca estimates that are 0.6 mmol too high (roughly equivalent to −6°C artifacts in SST), SIMS Sr/Ca timeseries track instrumental SST timeseries. We conclude that 3–4 SIMS analyses per month of coral growth can provide a much-needed quantitative check on the accuracy of fossil coral Sr/Ca-derived estimates of paleotemperature, even in moderately altered samples.We'd also like to thank Yolande Berta and Georgia Tech's Center for Nanostructure Characterization for providing access to their SEM facilities, and the Khaled bin Sultan Living Ocean Foundation and The Nature Conservancy for financial and logistical support for field excursions to Palmyra. Funding for this work was provided by the National Science Foundation (Award Numbers 1502832 and 2002458 to K.M.C) and the National Oceanic and Atmospheric Administration (Award Number: NA11OAR4310165 to K.M.C)
Laser (U-Th)/He thermochronology of detrital zircons as a tool for studying surface processes in modern catchments
Author Posting. © American Geophysical Union, 2013. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research: Earth Surface 118 (2013): 1333–1341, doi:10.1002/jgrf.20091.Detrital mineral thermochronology of modern sediments is a valuable tool for interrogating landscape evolution. Detrital zircon (U-Th)/He thermochronology is of particular interest because zircons are durable and withstand transport in glacial and fluvial systems far better than, for example, apatite. However, because of the time-intensive nature of conventional zircon (U-Th)/He thermochronology, most previous studies of this kind have relied on data for a few tens of grains, even though conventional wisdom holds that a substantially larger number is necessary for a robust characterization of the population of cooling ages in a sample. Here, we introduce a microanalytical approach to detrital zircon (U-Th)/He thermochronology that addresses many factors that can complicate the interpretation of conventional zircon (U-Th)/He data, particularly with respect to alpha ejection and injection and U + Th zoning. In addition, this technique permits the effective dating of naturally abraded and broken grains, and, therefore, lessens the potential for sampling bias. We apply both conventional and laser microprobe techniques to a detrital sample from the Ladakh Range in the northwestern Indian Himalaya, showing that the two yield very similar principal modes of apparent ages. However, the laser microprobe data yield a broader spectrum of ages than that of the conventional data set, which we interpret to be caused by bias related to the selection requirements for zircons used for conventional dating. This method thus provides a time-efficient route to obtaining a higher-resolution distribution of dates from a single sample, which will, in turn, yield higher-fidelity constraints regarding catchment-wide erosion rates for surface process studies.Funding for this project was provided by
NSF EAR-0642731, awarded to KVH and a Lewis and Clark Grant awarded
to AT-L.2014-01-2
Halogen (F, Cl) concentrations and Sr-Nd-Pb-B isotopes of the basaltic andesites from the southern Okinawa Trough: implications for the recycling of subducted serpentinites
Author Posting. © American Geophysical Union, 2021. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research: Solid Earth 126(3), (2021): e2021JB021709, https://doi.org/10.1029/2021JB021709.Serpentinites are increasingly recognized as playing an important role in the global geochemical cycle. However, discriminating the contributions of serpentinites to arc magmas from those of other subduction components is challenging. The Okinawa Trough is a back-arc basin developed behind the Ryukyu subduction zone, where magmas are extensively affected by sediment subduction. In this study, we reported the F-Cl concentrations and Sr-Nd-Pb-B isotopes of basaltic andesites from the Yaeyama Graben, Yonaguni Graben, and Irabu Knoll in the southern Okinawa Trough. The Irabu Knoll lavas show the most enrichment of fluid-mobile elements and F ± Cl, and have the heaviest B isotopes (δ11B: +6.6 ± 1.5‰). They also have decoupled Sr-Nd isotopes: higher 87Sr/86Sr (∼0.7049) but have no obvious decrease of 143Nd/144Nd (∼0.5128). Results from slab dehydration modeling and mixing calculations suggest that the heavy δ11B in the Irabu Knoll lavas is not consistent with fluids derived from altered oceanic crust (AOC), sediments, or wedge serpentinites (formed in the mantle wedge), but rather from slab serpentinites (formed within the subducting plate); sediments control the subduction input of Nd, whereas the decoupled Sr-Nd isotopes are most likely due to the excess radiogenic Sr carried by AOC fluids. Our results imply that recycling of serpentinite fluids and AOC fluids are usually coupled in subduction zones, as the arc lavas influenced by subducted serpentinite generally show Sr-Nd isotopes decoupling. The large variation of Sr-Nd-B isotopes observed in a relatively localized area is consistent with a focused migration through the mantle wedge of components from multiple sources.This study was funded by the National Natural Science Foundation of China (91958213), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB42020402), the China Postdoctoral Science Foundation (2019M662454), the Shandong Provincial Natural Science Foundation, China (ZR2020QD068 and ZR2020MD068), the International Partnership Program of the Chinese Academy of Sciences (133137KYSB20170003), the Special Fund for the Taishan Scholar Program of Shandong Province (ts201511061), and the China Scholarship Council (201709410550).2021-09-1
The boron and lithium isotopic composition of mid-ocean ridge basalts and the mantle
A global selection of 56 mid-ocean ridge basalt (MORB) glasses were analysed for Li and B abundances and isotopic compositions. Analytical accuracy and precision of analyses constitute an improvement over previously published MORB data and allow a more detailed discussion of the Li and B systematics of the crust-mantle system. Refined estimates for primitive mantle abundances ([Li]=1.39±0.10[Li]=1.39±0.10 μg/g and [B]=0.19±0.02[B]=0.19±0.02 μg/g) and depleted mantle abundances ([Li]=1.20±0.10[Li]=1.20±0.10 μg/g and [B]=0.077±0.010[B]=0.077±0.010 μg/g) are presented based on mass balance and on partial melting models that utilise observed element ratios in MORB.
Assimilation of seawater (or brine) or seawater-altered material beneath the ridge, identified by high Cl/KCl/K, causes significant elevation of MORB δ11Bδ11B and variable elevation in δ7Liδ7Li. The B isotope ratio is, hence, identified as a reliable indicator of assimilation in MORB and values higher than −6‰ are strongly indicative of shallow contamination of the magma.
The global set of samples investigated here were produced at various degrees of partial melting and include depleted and enriched MORB from slow and fast-spreading ridge segments with a range of radiogenic isotope signatures and trace element compositions. Uncontaminated (low-Cl/KCl/K) MORB show no significant boron isotope variation at the current level of analytical precision, and hence a homogenous B isotopic composition of δ11B=-7.1±0.9‰δ11B=-7.1±0.9‰ (mean of six ridge segments; 2SD). Boron isotope fractionation during mantle melting and basalt fractionation likely is small, and this δ11Bδ11B value reflects the B isotopic composition of the depleted mantle and the bulk silicate Earth, probably within ±0.4‰.
Our sample set shows a mean δ7Li=+3.5±1.0‰δ7Li=+3.5±1.0‰ (mean of five ridge segments; 2SD), excluding high-Cl/KCl/K samples. A significant variation of 1.0–1.5‰ exists among various ridge segments and among samples within individual ridge segments, but this variation is unrelated to differentiation, assimilation or mantle source indicators, such as radiogenic isotopes or trace elements. It, therefore, seems likely that kinetic fractionation of Li isotopes during magma extraction, transport and storage may generate δ7Liδ7Li excursions in MORB. No mantle heterogeneities, such as those generated by deeply recycled subducted materials, are invoked in the interpretation of the Li and B isotope data presented here, in contrast to previous work on smaller data sets.
Lithium and boron budgets for the silicate Earth are presented that are based on isotope and element mass balance. A refined estimate for the B isotopic composition of the bulk continental crust is given as δ11B=-9.1±2.4‰δ11B=-9.1±2.4‰. Mass balance allows the existence of recycled B reservoirs in the deep mantle, but these are not required. However, mass balance among the crust, sediments and seawater shows enrichment of 6Li6Li in the surface reservoirs, which requires the existence of 7Li7Li-enriched material in the mantle. This may have formed by the subduction of altered oceanic crust since the Archaean
Expert Panel Curation of 113 Primary Mitochondrial Disease Genes for the Leigh Syndrome Spectrum
OBJECTIVE: Primary mitochondrial diseases (PMDs) are heterogeneous disorders caused by inherited mitochondrial dysfunction. Classically defined neuropathologically as subacute necrotizing encephalomyelopathy, Leigh syndrome spectrum (LSS) is the most frequent manifestation of PMD in children, but may also present in adults. A major challenge for accurate diagnosis of LSS in the genomic medicine era is establishing gene-disease relationships (GDRs) for this syndrome with >100 monogenic causes across both nuclear and mitochondrial genomes. METHODS: The Clinical Genome Resource (ClinGen) Mitochondrial Disease Gene Curation Expert Panel (GCEP), comprising 40 international PMD experts, met monthly for 4 years to review GDRs for LSS. The GCEP standardized gene curation for LSS by refining the phenotypic definition, modifying the ClinGen Gene-Disease Clinical Validity Curation Framework to improve interpretation for LSS, and establishing a scoring rubric for LSS. RESULTS: The GDR with LSS across the nuclear and mitochondrial genomes was classified as definitive for 31/114 gene-disease relationships curated (27%); moderate for 38 (33%); limited for 43 (38%); and 2 as disputed (2%). Ninety genes were associated with autosomal recessive inheritance, 16 were maternally inherited, 5 autosomal dominant, and 3 X-linked. INTERPRETATION: GDRs for LSS were established for genes across both nuclear and mitochondrial genomes. Establishing these GDRs will allow accurate variant interpretation, expedite genetic diagnosis of LSS, and facilitate precision medicine, multi-system organ surveillance, recurrence risk counselling, reproductive choice, natural history studies and eligibility for interventional clinical trials. This article is protected by copyright. All rights reserved
Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders
Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci. However, the nature and mechanisms of these pleiotropic effects remain unclear. We performed analyses of 232,964 cases and 494,162 controls from genome-wide studies of anorexia nervosa, attention-deficit/hyper-activity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, and Tourette syndrome. Genetic correlation analyses revealed a meaningful structure within the eight disorders, identifying three groups of inter-related disorders. Meta-analysis across these eight disorders detected 109 loci associated with at least two psychiatric disorders, including 23 loci with pleiotropic effects on four or more disorders and 11 loci with antagonistic effects on multiple disorders. The pleiotropic loci are located within genes that show heightened expression in the brain throughout the lifespan, beginning prenatally in the second trimester, and play prominent roles in neurodevelopmental processes. These findings have important implications for psychiatric nosology, drug development, and risk prediction.Peer reviewe
Analysis of shared heritability in common disorders of the brain
ience, this issue p. eaap8757 Structured Abstract INTRODUCTION Brain disorders may exhibit shared symptoms and substantial epidemiological comorbidity, inciting debate about their etiologic overlap. However, detailed study of phenotypes with different ages of onset, severity, and presentation poses a considerable challenge. Recently developed heritability methods allow us to accurately measure correlation of genome-wide common variant risk between two phenotypes from pools of different individuals and assess how connected they, or at least their genetic risks, are on the genomic level. We used genome-wide association data for 265,218 patients and 784,643 control participants, as well as 17 phenotypes from a total of 1,191,588 individuals, to quantify the degree of overlap for genetic risk factors of 25 common brain disorders. RATIONALE Over the past century, the classification of brain disorders has evolved to reflect the medical and scientific communities' assessments of the presumed root causes of clinical phenomena such as behavioral change, loss of motor function, or alterations of consciousness. Directly observable phenomena (such as the presence of emboli, protein tangles, or unusual electrical activity patterns) generally define and separate neurological disorders from psychiatric disorders. Understanding the genetic underpinnings and categorical distinctions for brain disorders and related phenotypes may inform the search for their biological mechanisms. RESULTS Common variant risk for psychiatric disorders was shown to correlate significantly, especially among attention deficit hyperactivity disorder (ADHD), bipolar disorder, major depressive disorder (MDD), and schizophrenia. By contrast, neurological disorders appear more distinct from one another and from the psychiatric disorders, except for migraine, which was significantly correlated to ADHD, MDD, and Tourette syndrome. We demonstrate that, in the general population, the personality trait neuroticism is significantly correlated with almost every psychiatric disorder and migraine. We also identify significant genetic sharing between disorders and early life cognitive measures (e.g., years of education and college attainment) in the general population, demonstrating positive correlation with several psychiatric disorders (e.g., anorexia nervosa and bipolar disorder) and negative correlation with several neurological phenotypes (e.g., Alzheimer's disease and ischemic stroke), even though the latter are considered to result from specific processes that occur later in life. Extensive simulations were also performed to inform how statistical power, diagnostic misclassification, and phenotypic heterogeneity influence genetic correlations. CONCLUSION The high degree of genetic correlation among many of the psychiatric disorders adds further evidence that their current clinical boundaries do not reflect distinct underlying pathogenic processes, at least on the genetic level. This suggests a deeply interconnected nature for psychiatric disorders, in contrast to neurological disorders, and underscores the need to refine psychiatric diagnostics. Genetically informed analyses may provide important "scaffolding" to support such restructuring of psychiatric nosology, which likely requires incorporating many levels of information. By contrast, we find limited evidence for widespread common genetic risk sharing among neurological disorders or across neurological and psychiatric disorders. We show that both psychiatric and neurological disorders have robust correlations with cognitive and personality measures. Further study is needed to evaluate whether overlapping genetic contributions to psychiatric pathology may influence treatment choices. Ultimately, such developments may pave the way toward reduced heterogeneity and improved diagnosis and treatment of psychiatric disorders
Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors
Background Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. Methods We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors. Results Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged. Conclusions Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders.Peer reviewe
Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study
Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research
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