Efectividad de la conciliación judicial en la resolución de conflictos según la nueva ley procesal del trabajo Chiclayo-2022

El presente estudio tuvo por objetivo determinar si es efectiva la conciliación judicial en la resolución de conflictos según la nueva ley procesal del trabajo Chiclayo metodológicamente fue de tipo básica, de enfoque cualitativo de diseño no experimental transversal descriptiva, como participantes se escogieron a 35 expedientes de distintas materias en el derecho laboral, como técnica se empleó el análisis de expedientes cuyo instrumento fue el análisis documental, se obtuvo como resultado que, no es efectiva la conciliación judicial en la resolución de conflictos según la nueva ley procesal del trabajo en Chiclayo; por lo que se concluyó que la naturaleza de la conciliación es la solución rápida del conflicto suscitado entre las partes. En cuanto a su eficacia en su mayoría hay coincidencia de que no viene siendo eficaz el diseño de la audiencia de conciliación no solamente por su falta de implementación de técnicas de comunicación y negociación si no por la escasez de personal especializado en temas conciliatorios. la cultura de litigiosidad de las partes y de ética de los abogados asesores de las partes en algunos casos son factores determinantes para el logro de la conciliación

Efecto del extracto crudo del mesocarpio de Persea americana MILL var. fuerte en hiperlipidemia inducida en Oryctolagus cunniculus

Presently study is had using 24 especímenes of Oryctolagus cuniculus, to determine the effect of the raw extract of American Persea Mill var. strong in the induced hyperlipidemia. A design experimental growing stimulus has been used, being used biochemical methods and farmacodinámicos to determine the effect hypolipidemy. It was distributed to the specimens in 4 experimentation groups, with 6 animal c/u: Group I (he was not administered treatment), Group II (he was administered lovastatina to the dose of 0.33 mg/Kg p.c.), group III and group IV (they were administered the raw extract of the mesocarpio of american Persea Mill var. strong to the doses of 2.5 g/Kg p.c and 5 g/Kg p.c respectively), for 15 days. Concluding that: The raw extract of the mesocarpio of American Persea Mill var. strong to dose of 2,5 g /Kg p.c. /15 days it possesses effect hypolipidemy.En el presente estudio se han utilizando 24 especímenes de Oryctolagus cuniculus, para determinar el efecto del extracto crudo de Persea americana Mill var. fuerte en la hiperlipidemia inducida. Se ha empleado un diseño experimental estímulo creciente, utilizándose métodos bioquímicos y farmacodinámicos para determinar el efecto hipolipidémico.Se distribuyó a los especimenes en 4 grupos de experimentación, con 6 animales c/u: Grupo I (no se le administró tratamiento), Grupo II (se le administró lovastatina a la dosis de 0.33 mg/Kg p.c.), grupo III y grupo IV (se les administró el extracto crudo del mesocarpio de Persea americana Mill var. fuerte a las dosis de 2.5 g/Kg p.c y 5 g/Kg p.c respectivamente), por 15 días. Concluyendo que: El extracto crudo del mesocarpio de Persea americana Mill var. fuerte a dosis de 2,5 g /Kg p.c./15 días posee efecto hipolipidémico

Hitos Demográficos del Siglo XXI: Migración Internacional

La migración ha sido una constante en la historia mundial. Sin embargo, las migraciones que han tenido lugar desde principios del siglo XXI no tienen precedentes, ya que recientemente éstas han alcanzado su mayor volumen en la historia y presentan características que las diferencian de las observadas en periodos anteriores, lo que ha propiciado una nueva conceptualización del fenómeno, enmarcada en lo que algunos estudiosos llaman “la nueva era” de las migraciones internacionales (Arango, 2003, mencionado por Fernández, 2005). Este nuevo ciclo se caracteriza por una profusa re-configuración del mapa migratorio mundial, el cual parece dar cuenta hoy, de una auténtica mundialización migratoria, con una fuerte tendencia a la diversificación de rutas y conexiones origen-destino. El nuevo mapa es el correlato de un escenario de globalización económica, cultural e informacional, que estimula que segmentos amplios de la población respondan cada vez más rápidamente a informaciones y oportunidades que se originan más allá de las fronteras nacionales (CONAPO, 2009). De esta forma la nueva era de la globalización, se ha convertido en un asunto de especial trascendencia. Por un lado, la mejora y expansión de los sistemas de comunicación y transporte y la significativa reducción del tiempo y coste de desplazamiento, así como las disparidades económicas y la existencia de situaciones sociales y políticas extremas han propiciado el crecimiento de los movimientos transnacionales de personas y la intensificación de las presiones migratorias. En este sentido, España nunca ha sido ajena al fenómeno de las corrientes migratorias. Así por ejemplo, en los últimos años y durante la primera mitad del siglo XX y parte de la segunda, grandes contingentes de españoles emigraron hacia diferentes puntos de América Latina y Europa en busca de un empleo y mejor calidad de vida. Pero fue a finales del siglo pasado cuando España, impulsada por el acelerado ritmo de crecimiento económico adoptado en parte gracias a su integración económica en Europa, pasó de ser una economía emisora de emigrantes a una receptora de inmigrantes. Sin embargo, el fenómeno de la inmigración en España cobró verdadera importancia hasta principios del siglo XXI, cuando las fuertes oleadas masivas de personas provenientes de países en vías de desarrollo se dejaron sentir en su estructura poblacional y actividad laboral; de ésta manera, durante el primer quinquenio de este siglo si al 1 de enero del año 2000 los residentes extranjeros en España eran 0.9 millones (que representaban 2.3 por ciento de las personas empadronadas) al 1 de enero de 2005 ya eran 3.7 millones, es decir, 8.5 por ciento de la población residente en el país, habiéndose por tanto cuadriplicado el efectivo de extranjeros en tan sólo cinco años (González, 2006: 2-3; Gil, 2007: 1). Con base en lo anterior, el objetivo del presente trabajo consistió en analizar las características de los flujos de inmigración actuales en España procedentes de países latinoamericanos, enmarcados en la nueva re-configuración del mapa migratorio mundial

Multi-messenger observations of a binary neutron star merger

On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transient’s position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

Background: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. Methods: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. RESULTS: At 48 months, the median reduction from baseline in the high-sensitivity C-reactive protein level was 26 percentage points greater in the group that received the 50-mg dose of canakinumab, 37 percentage points greater in the 150-mg group, and 41 percentage points greater in the 300-mg group than in the placebo group. Canakinumab did not reduce lipid levels from baseline. At a median follow-up of 3.7 years, the incidence rate for the primary end point was 4.50 events per 100 person-years in the placebo group, 4.11 events per 100 person-years in the 50-mg group, 3.86 events per 100 person-years in the 150-mg group, and 3.90 events per 100 person-years in the 300-mg group. The hazard ratios as compared with placebo were as follows: in the 50-mg group, 0.93 (95% confidence interval [CI], 0.80 to 1.07; P = 0.30); in the 150-mg group, 0.85 (95% CI, 0.74 to 0.98; P = 0.021); and in the 300-mg group, 0.86 (95% CI, 0.75 to 0.99; P = 0.031). The 150-mg dose, but not the other doses, met the prespecified multiplicity-adjusted threshold for statistical significance for the primary end point and the secondary end point that additionally included hospitalization for unstable angina that led to urgent revascularization (hazard ratio vs. placebo, 0.83; 95% CI, 0.73 to 0.95; P = 0.005). Canakinumab was associated with a higher incidence of fatal infection than was placebo. There was no significant difference in all-cause mortality (hazard ratio for all canakinumab doses vs. placebo, 0.94; 95% CI, 0.83 to 1.06; P = 0.31). Conclusions: Antiinflammatory therapy targeting the interleukin-1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid-level lowering. (Funded by Novartis; CANTOS ClinicalTrials.gov number, NCT01327846.

Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials

Aims: The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial. Here we describe the baseline characteristics of participants in GALACTIC‐HF and how these compare with other contemporary trials. Methods and Results: Adults with established HFrEF, New York Heart Association functional class (NYHA) ≥ II, EF ≤35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic‐guided dosing: 25, 37.5 or 50 mg bid). 8256 patients [male (79%), non‐white (22%), mean age 65 years] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NT‐proBNP 1971 pg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTIC‐HF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure < 100 mmHg (n = 1127), estimated glomerular filtration rate < 30 mL/min/1.73 m2 (n = 528), and treated with sacubitril‐valsartan at baseline (n = 1594). Conclusions: GALACTIC‐HF enrolled a well‐treated, high‐risk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation

Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study

Summary Background Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries globally, and identified factors associated with mortality. Methods We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation, and Hirschsprung’s disease. Recruitment was of consecutive patients for a minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause, in-hospital mortality for all conditions combined and each condition individually, stratified by country income status. We did a complete case analysis. Findings We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal malformation, and 517 with Hirschsprung’s disease) from 264 hospitals (89 in high-income countries, 166 in middleincome countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male. Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3). Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups). Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in lowincome countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries; p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11], p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20 [1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention (ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed (ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65 [0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality. Interpretation Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between lowincome, middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger than 5 years by 2030

Spatial distribution of freshwater crustaceans in Antarctic and Subantarctic lakes

Antarctic and Subantarctic lakes are unique ecosystems with relatively simple food webs, which are likely to be strongly affected by climate warming. While Antarctic freshwater invertebrates are adapted to extreme environmental conditions, little is known about the factors determining their current distribution and to what extent this is explained by biogeography or climate. We explored the distribution of freshwater crustaceans (one of the most abundant and diverse group of organisms in Antarctic and Subantarctic lakes) across four biogeographic provinces (Continental Antarctic, CA; Maritime Antarctic, MA; Subantarctic islands, SA; and Southern Cool Temperate, SCT) based on the literature, predicting that species distribution would be determined by biogeography, spatial autocorrelation among regions (in relation to dispersal) and climate. We found that variation in species composition was largely explained by the joint effect of spatial autocorrelation and climate, with little effect of biogeography - only regions within the SA province had a clearly distinct species composition. This highlights a plausible main influence of crustacean dispersal - mainly through migratory seabirds - and suggests that some regions will be more affected by climate warming than others, possibly in relation to the existence of nearby sources of colonists

Missing food: the case of postharvest grain losses in sub-Saharan Africa

Low-income, food-deficit countries have become especially concerned about the global and national food situation over the past three years. While the proximate cause of this heightened concern was the surge in food prices that began in 2006 and peaked in mid-2008, concerns remain for other reasons, among them the higher market-clearing price levels that now seem to prevail, continuing price volatility, and the risk of intermittent food shortages occurring repeatedly far into the future. For lower-income Sub-Saharan Africa (SSA) countries, ongoing contributing factors include persistently low productivity, difficulty adapting to climate change, financial difficulties (inability to handle the burden of high food or fuel prices or a credit squeeze), and increased dependence on food aid. Yet there is an additional, often-forgotten factor that exacerbates food insecurity: postharvest losses (PHL). They can and do occur all along the chain from farm to fork, which reduces real income for all consumers. This especially affects the poor, as such a high percentage of their disposable income is devoted to staple foods. Interest in the reduction of PHL is not new. After the mid-1970s food crisis, considerable development investment went into PHL reduction for staple crops. In fact, in 1975, the United Nations brought postharvest storage losses into international focus when it declared that “further reduction of postharvest food losses in developing countries should be undertaken as a matter of priority” (FAO 1981). Unfortunately, once real commodity prices resumed their historical downward trend, the policy shifted to emphasize food security through economic liberalization and trade. The world seems to have forgotten the importance of postharvest food losses in the African grain sector, and those networks or programs that sought to reduce them, such as FAO’s Prevention of Food Losses Program and the Global Postharvest Forum (PhAction), have fallen into abeyance. The low adoption of the PHL technologies promoted in various SSA countries has also led to the declining investments in this area. With renewed emphasis on agriculture, and in the aftermath of the recent food and financial crises, the profile of PHL has been significantly raised. Interventions in PHL reduction are seen as an important element of the efforts of many agencies to reduce food insecurity in SSA. PHL is increasingly recognized as part of an integrated approach to realizing agriculture’s full potential to meet the world’s increasing food and energy needs. Therefore, reducing PHL—along with making more effective uses of today’s crops, improving productivity on existing farmland, and sustainably bringing additional acreage into production— is critical to facing the challenge of feeding an increased world population. Postharvest losses feature prominently in recent global initiatives such as the Comprehensive Framework for Action issued in 2009 by the UN High-Level Task Force for Food Security and Nutrition after the global food crisis, the Global Agricultural and Food Security Program endorsed by the World Bank in January 2010, and the recently reformed Committee on World Food Security (CFS). It is clearly recognized that the context of agricultural production and marketing in SSA has evolved since the 1970s and 1980s, as have the challenges associated with PHL reduction. Changes have included (i) increasing competition from international markets in the wake of market liberalization; (ii) the state’s withdrawal from grain marketing activities that provided the commercial sector with variable technical support in grain handling and storage; (iii) development of more sophisticated grain value chains coordinated by an emerging private sector; (iv) increased regional integration, which has resulted in the easier movement of grain but with limited monitoring of quality; (v) impacts of HIV/AIDS and urbanization on labor availability; (vi) spread of the larger grain borer, a devastating storage pest; (vii) introduction of varieties with high yield that require inputs and are more susceptible to pest attack; (viii) increasing land fragmentation, with a corresponding decrease of farm size, accompanied by declining soil fertility; (ix) erratic weather patterns that have led to recurrent failures in harvests and consequent food shortages; and (x) the erosion of postharvest expertise to serve the needs of developing country producers and supply chains. Limited success in reducing PHL and a shrinking technical capacity to respond to the challenges of PHL reduction highlight the need to build up a knowledge base of lessons to raise the profile of PHL and to provide best practices and practical recommendations for scaling up. Consequently, the World Bank undertook this policy-oriented research of the current state of knowledge and technology related to PHL reduction. It did so in collaboration with FAO, with the expertise of the U.K. Natural Resources Institute, and with contributions of key PHL stakeholders and institutions, capturing lessons from past interventions that could provide insights for the implementation of effective PHL strategies. This analysis looks at the evolution of public and private sector responses over the last two decades to reduce losses along the various stages of the supply chains and supports and to build on the African Development Bank’s current Post Harvest Loss Initiative for SSA. It also highlights critical factors that determine technology uptake and sustainable use, with a focus on gender dimensions of technology adoption for reducing PHL. The main findings of this research are discussed in the following pages