732 research outputs found
Programa de Educação Tutorial
Objetivo: Apresentar o conjunto de açÔes da ĂĄrea do ensino, pesquisa e extensĂŁo de dois grupos do Programa de Educação Tutorial (PET), atuantes na ĂĄrea da Educação FĂsica. Metodologia: Trata-se de um relato de experiĂȘncias relativo Ă s atividades do PET-BiomecĂąnica e PET-Educação FĂsica, entre os anos de 2011-2019, na cidade de Petrolina-PE, regiĂŁo do SertĂŁo pernambucano. Essas equipes sĂŁo interdisciplinares, compostas por 12 discentes bolsistas, alĂ©m de voluntĂĄrios, todos sob a coordenação de um tutor. Resultados e discussĂŁo: Verificou-se que os grupos PET vĂȘm contribuindo significativamente para indissociabilidade entre o ensino, a pesquisa e a extensĂŁo, qualificando a formação dos futuros professores de Educação FĂsica da regiĂŁo. Ao longo dos anos, as equipes desenvolveram diferentes ferramentas, que proporcionam a troca de conhecimentos com a comunidade local e, por conseguinte, o desenvolvimento de novas metodologias de ensino, em carĂĄter interdisciplinar. ConclusĂŁo: Com base na trĂade ensino, pesquisa e extensĂŁo as açÔes dos grupos PET apresentam grande potencial Ă formação acadĂȘmica, porque informam e instrumentalizam os discentes sobre temas relevantes da ĂĄrea da Educação FĂsica, SaĂșde e Educação. Ademais, as açÔes auxiliaam os petianos na elaboração e fixação dos conhecimentos de sala de aula, alĂ©m do desenvolvimento de princĂpios de cidadania
Influence of Clinical Status and Parasite Load on Erythropoiesis and Leucopoiesis in Dogs Naturally Infected with Leishmania (Leishmania) chagasi
Background: The bone marrow is considered to be an important storage of parasites in Leishmania-infected dogs, although little is known about cellular genesis in this organ during canine visceral leishmaniasis (CVL).
Methodology/Principal Findings: The aim of the present study was to evaluate changes in erythropoiesis and leucopoiesis in bone marrow aspirates from dogs naturally infected with Leishmania chagasi and presenting different clinical statuses and bone marrow parasite densities. The evolution of CVL from asymptomatic to symptomatic status was accompanied by increasing parasite density in the bone marrow. The impact of bone marrow parasite density on cellularity was similar in dogs at different clinical stages, with animals in the high parasite density group. Erythroid and eosinophilic hypoplasia, proliferation of neutrophilic precursor cells and significant increases in lymphocytes and plasma cell numbers were the major alterations observed. Differential bone marrow cell counts revealed increases in the myeloid:erythroid ratio associated to increased numbers of granulopoietic cells in the different clinical groups compared with non-infected dogs.
Conclusions: Analysis of the data obtained indicated that the assessment of bone marrow constitutes an additional and useful tool by which to elaborate a prognosis for CVL
Anisotropy studies around the galactic centre at EeV energies with the Auger Observatory
Data from the Pierre Auger Observatory are analyzed to search for
anisotropies near the direction of the Galactic Centre at EeV energies. The
exposure of the surface array in this part of the sky is already significantly
larger than that of the fore-runner experiments. Our results do not support
previous findings of localized excesses in the AGASA and SUGAR data. We set an
upper bound on a point-like flux of cosmic rays arriving from the Galactic
Centre which excludes several scenarios predicting sources of EeV neutrons from
Sagittarius . Also the events detected simultaneously by the surface and
fluorescence detectors (the `hybrid' data set), which have better pointing
accuracy but are less numerous than those of the surface array alone, do not
show any significant localized excess from this direction.Comment: Matches published versio
Adaptive Immunity against Leishmania Nucleoside Hydrolase Maps Its C-Terminal Domain as the Target of the CD4+ T CellâDriven Protective Response
Nucleoside hydrolases (NHs) show homology among parasite protozoa, fungi and bacteria. They are vital protagonists in the establishment of early infection and, therefore, are excellent candidates for the pathogen recognition by adaptive immune responses. Immune protection against NHs would prevent disease at the early infection of several pathogens. We have identified the domain of the NH of L. donovani (NH36) responsible for its immunogenicity and protective efficacy against murine visceral leishmaniasis (VL). Using recombinant generated peptides covering the whole NH36 sequence and saponin we demonstrate that protection against L. chagasi is related to its C-terminal domain (amino-acids 199â314) and is mediated mainly by a CD4+ T cell driven response with a lower contribution of CD8+ T cells. Immunization with this peptide exceeds in 36.73±12.33% the protective response induced by the cognate NH36 protein. Increases in IgM, IgG2a, IgG1 and IgG2b antibodies, CD4+ T cell proportions, IFN-Îł secretion, ratios of IFN-Îł/IL-10 producing CD4+ and CD8+ T cells and percents of antibody binding inhibition by synthetic predicted epitopes were detected in F3 vaccinated mice. The increases in DTH and in ratios of TNFα/IL-10 CD4+ producing cells were however the strong correlates of protection which was confirmed by in vivo depletion with monoclonal antibodies, algorithm predicted CD4 and CD8 epitopes and a pronounced decrease in parasite load (90.5â88.23%; pâ=â0.011) that was long-lasting. No decrease in parasite load was detected after vaccination with the N-domain of NH36, in spite of the induction of IFN-Îł/IL-10 expression by CD4+ T cells after challenge. Both peptides reduced the size of footpad lesions, but only the C-domain reduced the parasite load of mice challenged with L. amazonensis. The identification of the target of the immune response to NH36 represents a basis for the rationale development of a bivalent vaccine against leishmaniasis and for multivalent vaccines against NHs-dependent pathogens
Evaluation of parameters related to libido and semen quality in Zebu bulls naturally infected with Trypanosoma vivax
Effect of light intensity, light duration and photoperiods in the performance of an outdoor photobioreactor for urban wastewater treatment
[EN] A series of eight experiments were carried out to analyse the effects of light intensity, light duration and photoperiods on a microalgae culture for treating AnMBR effluent at an outdoor photobioreactor (PBR) plant.
Improved performance was achieved in terms of nutrient recovery rates, biomass productivity and effluent nutrient concentrations at a higher net photon flux. However, the higher irradiance was also responsible for lower biomass productivity:light irradiance ratios.
None of the experiments with different lighting regimes and the same net photon flux showed any significant differences. The data obtained suggest that microalgae performance in this system did not depend on the time of day when light was applied or the length of the photoperiods, but on the net photon flux. No photoinhibiton was observed in any of the experiments, probably because of the significant shadow effect on the microalgae in the PBRs.This research work was supported by the Spanish Ministry of Economy and Competitiveness (MINECO, Projects CTM2014-54980-C2-1-R, CTM2014-54980-C2-2-R, CTM2011-28595-C02-01, and CTM2011-28595-C02-02) jointly with the European Regional Development Fund (ERDF), both of which are gratefully acknowledged. It was also supported by the Spanish Ministry of Education, Culture and Sport via a pre-doctoral FPU fellowship to author J. GonzĂĄlez-Camejo (FPU14/05082).Gonzalez-Camejo, J.; Viruela Navarro, A.; Ruano GarcĂa, MV.; Barat, R.; Seco Torrecillas, A.; Ferrer, J. (2019). Effect of light intensity, light duration and photoperiods in the performance of an outdoor photobioreactor for urban wastewater treatment. Algal Research. 40:1-11. https://doi.org/10.1016/j.algal.2019.101511S1114
Model-independent evidence for contributions to decays
The data sample of decays acquired with the
LHCb detector from 7 and 8~TeV collisions, corresponding to an integrated
luminosity of 3 fb, is inspected for the presence of or
contributions with minimal assumptions about
contributions. It is demonstrated at more than 9 standard deviations that
decays cannot be described with
contributions alone, and that contributions play a dominant role in
this incompatibility. These model-independent results support the previously
obtained model-dependent evidence for charmonium-pentaquark
states in the same data sample.Comment: 21 pages, 12 figures (including the supplemental section added at the
end
Quantum numbers of the state and orbital angular momentum in its decay
Angular correlations in decays, with , and , are used to measure
orbital angular momentum contributions and to determine the value of
the meson. The data correspond to an integrated luminosity of 3.0
fb of proton-proton collisions collected with the LHCb detector. This
determination, for the first time performed without assuming a value for the
orbital angular momentum, confirms the quantum numbers to be .
The is found to decay predominantly through S wave and an upper limit
of at C.L. is set on the fraction of D wave.Comment: 16 pages, 4 figure
Observation of associated near-side and away-side long-range correlations in âsNN=5.02ââTeV proton-lead collisions with the ATLAS detector
Two-particle correlations in relative azimuthal angle (ÎÏ) and pseudorapidity (Îη) are measured in âsNN=5.02ââTeV p+Pb collisions using the ATLAS detector at the LHC. The measurements are performed using approximately 1ââÎŒb-1 of data as a function of transverse momentum (pT) and the transverse energy (ÎŁETPb) summed over 3.1<η<4.9 in the direction of the Pb beam. The correlation function, constructed from charged particles, exhibits a long-range (2<|Îη|<5) ânear-sideâ (ÎÏâŒ0) correlation that grows rapidly with increasing ÎŁETPb. A long-range âaway-sideâ (ÎÏâŒÏ) correlation, obtained by subtracting the expected contributions from recoiling dijets and other sources estimated using events with small ÎŁETPb, is found to match the near-side correlation in magnitude, shape (in Îη and ÎÏ) and ÎŁETPb dependence. The resultant ÎÏ correlation is approximately symmetric about Ï/2, and is consistent with a dominant cosâĄ2ÎÏ modulation for all ÎŁETPb ranges and particle pT
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