85 research outputs found
PREDICTORS OF IN-HOSPITAL MORTALITY IN CRITICALLY ILL PATIENTS WITH SECONDARY AND TERTIARY PERITONITIS
- Author
- Publication venue
- Springer Nature
- Publication date
- 01/01/2015
- Field of study
Search for the standard model Higgs boson at LEP
- Author
- Abbaneo D
- Abbaneo D
- Abbiendi G
- Abbiendi G
- Abdallah J
- Abreu P
- Achard P
- Adam W
- Adriani O
- Adzic P
- Affholderbach K
- Aguilar-Benitez M
- Ainsley C
- Akesson PF
- Albrecht T
- Alcaraz J
- Alderweireld T
- Alemanni G
- Alemany-Fernandez R
- Alexander G
- Allaby J
- Allison J
- Allmendinger T
- Allport PP
- Aloisio A
- Alviggi MG
- Amaldi U
- Amapane N
- Amaral P
- Amato S
- Anagnostou G
- Anashkin E
- Anderhub H
- Anderson KJ
- Andreazza A
- Andreev VP
- Andringa S
- Anjos N
- Anselmo F
- Antilogus P
- Antonelli A
- Antonelli M
- Apel WD
- Arcelli S
- Arefiev A
- Armstrong SR
- Arnoud Y
- Asai S
- Ask S
- Asman B
- Augustin JE
- Augustinus A
- Awunor O
- Axen D
- Azemoon T
- Aziz T
- Azuelos G
- Azzurri P
- Baarmand M
- Badaud F
- Bagliesi G
- Bagnaia P
- Bailey I
- Baillon P
- Bajo A
- Baksay G
- Baksay L
- Baldew SV
- Ballestrero A
- Bambade P
- Banerjee S
- Banerjee S
- Barate R
- Barate R
- Barberio E
- Barbier R
- Barczyk A
- Bardin D
- Barillere R
- Barker G
- Barklow T
- Barlow RJ
- Baroncelli A
- Bartalini P
- Basile M
- Batalova N
- Batley RJ
- Battaglia M
- Battiston R
- Baubillier M
- Bay A
- Becattini F
- Bechtle P
- Becker U
- Becks KH
- Begalli M
- Behner F
- Behnke T
- Behrmann A
- Bell KW
- Bell PJ
- Bella G
- Bellerive A
- Bellucci L
- Ben-Haim E
- Bencivenni G
- Benekos N
- Benelli G
- Benvenuti A
- Berat C
- Berbeco R
- Berdugo J
- Berges P
- Berggren M
- Berkelman K
- Berntzon L
- Bertrand D
- Bertucci B
- Besancon M
- Besson N
- Betev BL
- Bethke S
- Beuselinck R
- Biasini M
- Biebell O
- Biglietti M
- Biland A
- Binnie DM
- Blair GA
- Blaising JJ
- Bloch D
- Bloch-Devaux B
- Blom M
- Blondel A
- Bloodworth IJ
- Bluj M
- Blumenschein U
- Blyth SC
- Bobbink GJ
- Boccali T
- Bock P
- Boeriun O
- Bohm A
- Bohrer A
- Boix G
- Boldizsar L
- Bologna G
- Bonacorsi D
- Bonesini M
- Bonissent A
- Boonekamp M
- Booth CN
- Booth PSL
- Borean C
- Borgia B
- Borisov G
- Bossi F
- Botner O
- Boucrot J
- Bouhova-Thacker E
- Boumediene D
- Bouquet B
- Bourilkov D
- Bourquin M
- Boutemeur M
- Bowcock TJV
- Bowdery CK
- Boyko I
- Braccini S
- Bracko M
- Braibant S
- Brandt S
- Branson JG
- Bravo S
- Brenner R
- Brient JC
- Brigliadori L
- Brochu F
- Brodet E
- Brown RM
- Bruckman P
- Bruneliere R
- Brunet JM
- Buchmuller O
- Buesser K
- Bugge L
- Buijs A
- Burckhart HJ
- Burger JD
- Burger WJ
- Buschmann P
- Cai XD
- Callot O
- Calvi M
- Cameron W
- Campana R
- Campana S
- Camporesi T
- Canale V
- Capell M
- Capon G
- Carena F
- Carlino G
- Carnegie RK
- Caron B
- Carr J
- Cartacci A
- Carter AA
- Carter JR
- Cartwright S
- Casado MP
- Casaus J
- Castro N
- Cattaneo A
- Cavallari F
- Cavallo F
- Cavallo N
- Cavanaugh R
- Cecchi C
- Cerrada M
- Cerutti F
- Chamizo M
- Chang CY
- Chang YH
- Chapkin M
- Charlton DG
- Charpentier P
- Checchia P
- Chemarin M
- Chen A
- Chen G
- Chen GM
- Chen HF
- Chen HS
- Chiarella V
- Chiefari G
- Chierici R
- Chiliapnikov P
- Chmeissani M
- Chudoba J
- Chung SU
- Cieslik K
- Cifarelli L
- Cindolo F
- Ciulli V
- Clare I
- Clare R
- Clarke DP
- Clerbaux B
- Clifft RW
- Coignet G
- Colaleo A
- Colas P
- Coles J
- Colino N
- Collins P
- Combley F
- Contri R
- Cosme G
- Cossutti F
- Costa MJ
- Costantini S
- Cowan G
- Coyle P
- Cranmer K
- Crawley B
- Creanza D
- Crennell D
- Crespo JM
- Csilling A
- Cucciarelli S
- Cuevas J
- Cuffiani M
- Curtil C
- D'Hondt J
- da Silva T
- Da Silva W
- Dado S
- Dai TS
- Dallavalle GM
- Dallison S
- Dalmau J
- David A
- Davier M
- Davies G
- De Angelis A
- de Asmundis R
- De Boer W
- De Bonis I
- De Clercq C
- De Filippis N
- de Guevara PL
- de Jong R
- de la Cruz B
- De Lotto B
- De Maria N
- De Min A
- de Palma M
- de Paula L
- De Roeck A
- De Salvo A
- De Vivie de Regie JB
- De Wolf EA
- Debreczeni J
- Decamp D
- Deglon P
- Degre A
- Deiters K
- Della Ricca G
- della Volpe D
- Delmeire E
- Denes P
- DeNotaristefani F
- Desch K
- Dessagne S
- Dhamotharan S
- Di Ciaccio L
- Di Simone A
- Diemoz M
- Dienes B
- Dierckxsens M
- Dietl H
- Dionisi C
- Dissertori G
- Dittmar M
- Donkers M
- Doria A
- Dornan PJ
- Doroba K
- Dova MT
- Drees J
- Drevermann H
- Dris M
- Dubbert J
- Duchesneau D
- Duchovni E
- Duckeck G
- Duerdoth IP
- Duflot L
- Duinker P
- Ealet A
- Echenard B
- Edgecock TR
- Eigen G
- Ekelof T
- El Mamouni H
- Elfgren E
- Eline A
- Ellert M
- Ellis G
- Elsing M
- Engler A
- Eppling FJ
- Etzion E
- Ewers A
- Extermann P
- Fabbri F
- Fabbro B
- Falagan MA
- Falciano S
- Falvard A
- Fanourakis G
- Fassouliotis D
- Favara A
- Fay J
- Fayolle D
- Fedin O
- Feindt M
- Felcini M
- Feld L
- Ferguson DPS
- Ferguson T
- Fernandez E
- Fernandez J
- Fernandez-Bosman M
- Ferrari P
- Ferrer A
- Ferro F
- Fesefeldt H
- Fiandrini E
- Fiedler F
- Field JH
- Filthaut F
- Finch AJ
- Fisher PH
- Fisher W
- Fisk I
- Flagmeyer U
- Fleck I
- Foa L
- Focardi E
- Foeth H
- Fokitis E
- Forconi G
- Ford M
- Forty RW
- Foster F
- Fouchez D
- Frank M
- Freudenreich K
- Frey A
- Fulda-Quenzer F
- Furetta C
- Furtjes A
- Fuster J
- Gagnon P
- Galaktionov Y
- Gandelman M
- Ganguli SN
- Ganis G
- Gao Y
- Garcia C
- Garcia-Abia P
- Garcia-Bellido A
- Garrido L
- Gary JW
- Gataullin M
- Gavillet P
- Gay P
- Gaycken G
- Gazis E
- Geich-Gimbel C
- Gentile S
- Geweniger C
- Ghete VM
- Giacomelli G
- Giacomelli P
- Giagu S
- Giammanco A
- Giannini G
- Gianotti F
- Giassi A
- Girone M
- Girtler P
- Giunta M
- Gokieli R
- Goldberg J
- Golob B
- Gomez-Ceballos G
- Goncalves P
- Gong ZF
- Gonzalez S
- Goy C
- Grauges E
- Graziani E
- Green MG
- Greening TC
- Grenier G
- Grimm O
- Grivaz JF
- Grosdidier G
- Gross E
- Gruenewald MW
- Grunhaus J
- Grupen C
- Gruwe M
- Grzelak K
- Guida M
- Gunther PO
- Gupta A
- Gupta VK
- Gurtu A
- Gutay LJ
- Guy J
- Haag C
- Haas D
- Hajdu C
- Hallgren A
- Hamacher K
- Hamann M
- Hamilton K
- Hanke P
- Hansen J
- Hansen JB
- Hansen JD
- Hansen JR
- Hansen PH
- Hanson GG
- Harder K
- Harel A
- Harin-Dirac M
- Harvey J
- Hatzifotiadou D
- Haug S
- Hauler F
- Hauschild M
- Hauschildt J
- Hawkes CM
- Hawkings R
- Hayes OJ
- He H
- Hebbeker T
- Hedberg V
- Heister A
- Hemingway RJ
- Henneche M
- Hensel C
- Hepp V
- Herr H
- Herten G
- Herve A
- Hess J
- Heuer RD
- Heusse P
- Hill JC
- Hill RD
- Hirschfelder J
- Hodgson PN
- Hofer H
- Hoffman J
- Hoffman K
- Holldorfer F
- Holmgren SO
- Holt PJ
- Holzner G
- Homer RJ
- Horvath D
- Hou SR
- Houlden MA
- Howard R
- Hu H
- Hu Y
- Huang X
- Hughes G
- Hultqvist K
- Huntemeyer P
- Hutchcroft DE
- Huttmann K
- Iaselli G
- Igo-Kemenes P
- Ishii K
- Jacholkowska A
- Jackson JN
- Jakobs K
- Janot P
- Jarlskog G
- Jarry P
- Jeans D
- Jeremie H
- Jezequel S
- Jin BN
- Jin S
- Johansson EK
- Johansson PD
- Jones LT
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- Jonsson P
- Joram C
- Josa-Mutuberria I
- Jost B
- Jousset J
- Jovanovic P
- Jungermann L
- Junk TR
- Kachelhoffer T
- Kado M
- Kafer D
- Kanaya N
- Kanzaki J
- Kapusta F
- Karapetian G
- Karlen D
- Kartvelishvili V
- Katsanevas S
- Katsoufis E
- Kaur M
- Kawagoe K
- Kawamoto T
- Kayser F
- Keeler RK
- Kellogg RG
- Kennedy BW
- Kennedy J
- Kernel G
- Kersevan BP
- Kienzle-Focacci MN
- Kiiskinen A
- Kile J
- Kim DH
- Kim JK
- King BT
- Kirkby J
- Kittel W
- Kjaer NJ
- Klein K
- Kleinknecht K
- Klier A
- Klimentov A
- Kluge EE
- Kluit P
- Kluth S
- Kneringer E
- Kobayashi T
- Kobel M
- Kokkinias P
- Komamiya S
- Konig AC
- Konstantinidis N
- Kopal M
- Kormos L
- Kourkoumelis C
- Koutsenko V
- Kouznetsov O
- Kowalewski RV
- Kraber M
- Kraemer RW
- Kramer T
- Krenz W
- Kress T
- Krieger P
- Krop D
- Kruger A
- Kruger K
- Krumstein Z
- Kucharczyk M
- Kuhn D
- Kunin A
- Kupper M
- Kyriakis A
- Lafferty GD
- Laktineh I
- Lamsa J
- Lancon E
- Landi G
- Landsman H
- Lanske D
- Laurelli P
- Layter JG
- Le Coultre P
- Le Goff JM
- Lebeau M
- Lebedev A
- Lebrun P
- Lecomte P
- Lecoq P
- Leder G
- Ledroit F
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- Lees JP
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- Leibenguth G
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- Leitner R
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- Lemaitre V
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- Marchant TE
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- Mnich J
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- Mori T
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- Moutoussi A
- Muanza GS
- Mueller U
- Muenich K
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- Musicar B
- Musy M
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- Myatt G
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- Nakamura I
- Napolitano M
- Nassiakou M
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- Newman H
- Ngac A
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- Nikolenko M
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- Vodopianov I
- Vogel H
- Vogt H
- Vollmer CF
- von Krogh J
- von Wimmersperg-Toeller JH
- Vorobiev I
- Vorobyov AA
- Voss H
- Vossebeld J
- Vrba V
- Waananen A
- Wachsmuth H
- Wadhwa M
- Wahlen H
- Waller D
- Wallraff W
- Wang M
- Wang T
- Wang XL
- Wang ZM
- Ward CP
- Ward DR
- Ward JJ
- Washbrook AJ
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- Watkins PM
- Watson AT
- Watson NK
- Weber M
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- Well PS
- Wengler T
- Wermes N
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- Wetterling D
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- Wienemann P
- Wilkens H
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- Wolf G
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- Wu SL
- Wu SX
- Wu X
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- Wyatt TR
- Wynhoff S
- Xia L
- Xie Y
- Xu R
- Xu ZZ
- Xue S
- Yamamoto J
- Yamashita S
- Yang BZ
- Yang CG
- Yang HJ
- Yang M
- Yeh SC
- Yuan C
- Yushchenko O
- Zachariadou K
- Zalewska A
- Zalewski P
- Zalite A
- Zalite Y
- Zavrtanik D
- Zeitnitz C
- Zer-Zion D
- Zhang J
- Zhang L
- Zhang ZP
- Zhao J
- Zhao W
- Zhu GY
- Zhu RY
- Zhuang HL
- Zhuravlov V
- Zichichi A
- Ziegler T
- Zilizi G
- Zimin NI
- Zimmermann B
- Zintchenko A
- Zito G
- Zivkovic L
- Zobernig G
- Zoller M
- Zupan M
- Publication venue
- ELSEVIER SCIENCE BV
- Publication date
- 17/07/2003
- Field of study
Glial Innate Immunity Generated by Non-Aggregated Alpha-Synuclein in Mouse: Differences between Wild-type and Parkinson's Disease-Linked Mutants
- Author
- A Klegeris
- A Klegeris
- AD Reynolds
- AD Reynolds
- AD Reynolds
- Adahir Labrador-Garrido
- B Mirza
- BI Giasson
- C Knott
- C Richter-Landsberg
- C Roodveldt
- CA Colton
- CE Moussa
- Christian C. Lachaud
- Christopher A. Waudby
- Christopher M. Dobson
- Cintia Roodveldt
- CM Long-Smith
- CW Bertoncini
- CW Bertoncini
- CY Chung
- David Pozo
- DC Wu
- DJ Moore
- DK Stone
- E Croisier
- EC Hirsch
- EJ Benner
- EJ Lee
- Elena Gonzalez-Rey
- F Chiti
- F Mori
- G Candiano
- H Schagger
- HA Lashuel
- HJ Lee
- I Wittig
- J Liu
- J Mestas
- J Saura
- JH Dufour
- JJ Zarranz
- JL Eriksen
- JM Souza
- Joseph Najbauer
- JY Park
- JY Sung
- JY Sung
- LI Golbe
- LS Forno
- M Delgado
- M Reale
- M Rentzos
- M Schwartz
- M Vila
- Mario Delgado
- Marta Caro
- MG Spillantini
- MH Polymeropoulos
- MM Dedmon
- MP Thomas
- MR Cookson
- NB Cole
- O Barreiro
- OM El-Agnaf
- OM El-Agnaf
- PH Jensen
- PH Weinreb
- PJ Spira
- PL McGeer
- R Borghi
- R Kruger
- R Sanchez-Pernaute
- Rafael Fernandez-Montesinos
- RB Banati
- RG Perez
- RR Rich
- S Bostantjopoulou
- S Gangemi
- S Kim
- S Papapetropoulos
- S Theodore
- SA Austin
- SH Joo
- SJ Lee
- T Gasser
- V Bonifati
- V Sanchez-Guajardo
- W Hoyer
- W Zhang
- W Zhang
- X Su
- X Su
- XL Gu
- YS Kim
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2010
- Field of study
Background: Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized pathologically by the presence in the brain of intracellular protein inclusions highly enriched in aggregated alpha-synuclein (alpha-Syn). Although it has been established that progression of the disease is accompanied by sustained activation of microglia, the underlying molecules and factors involved in these immune-triggered mechanisms remain largely unexplored. Lately, accumulating evidence has shown the presence of extracellular alpha-Syn both in its aggregated and monomeric forms in cerebrospinal fluid and blood plasma. However, the effect of extracellular alpha-Syn on cellular activation and immune mediators, as well as the impact of familial PD-linked alpha-Syn mutants on this stimulation, are still largely unknown.Methods and Findings: In this work, we have compared the activation profiles of non-aggregated, extracellular wild-type and PD-linked mutant alpha-Syn variants on primary glial and microglial cell cultures. After stimulation of cells with alpha-Syn, we measured the release of Th1- and Th2-type cytokines as well as IP-10/CXCL10, RANTES/CCL5, MCP-1/CCL2 and MIP-1 alpha/CCL3 chemokines. Contrary to what had been observed using cell lines or for the case of aggregated alpha-Syn, we found strong differences in the immune response generated by wild-type alpha-Syn and the familial PD mutants (A30P, E46K and A53T).Conclusions: These findings might contribute to explain the differences in the onset and progression of this highly debilitating disease, which could be of value in the development of rational approaches towards effective control of immune responses that are associated with PD
Spontaneous Breathing in Early Acute Respiratory Distress Syndrome: Insights From the Large Observational Study to UNderstand the Global Impact of Severe Acute Respiratory FailurE Study
- Author
- Abad RD
- Abe T
- Abroug F
- Adams JC
- Adamsson RO
- Adolfsson A
- Aguilar RZ
- Aguirre JS
- Aguirre-Bermeo H
- Aisa TM
- Aisiku I
- Ajetunmobi OO
- Aker M
- Akyol OO
- Al Dorzi HM
- Al Jabbary AS
- Albaiceta GM
- Albarrak MM
- Albiero D
- Alda RS
- Alejandro RV
- Alexander P
- Algaba Á
- Aliaga FA
- Alisasis AU
- Allan RM
- Allue RM
- Almekhlaf G
- Alonso JG
- Altaf W
- Alvarez AM
- Alvarez J
- Amin P
- Amir F
- Amor M
- An Y
- Andersen FH
- Andoh K
- Andruszkiewicz P
- Aneman A
- Antonelli MM
- Antônio ACP
- Aoki N
- Appelberg H
- Arabi Y
- Arabi YM
- Araujo AM
- Arizmendi A
- Arnal JM
- Artiga MJD
- Artigas A
- Ascoli A
- Au SM
- Avila LE
- Azad R
- Azevedo LC
- Baboi L
- Badie JC
- Bailey IM
- Bailey MB
- Bajwa E
- Balkhi H
- Baltus T
- Banner-Goodspeed VM
- Barberet G
- Baron RM
- Baronia AK
- Barratt-Due A
- Barros FM
- Barros NC
- Batra H
- Battle CE
- Bauer PR
- Beck E
- Beck O
- Bedreag OH
- Beegle SH
- Beitler JR
- Bellani G
- Bellani G.
- Beloncle F
- Ben Souissi A
- Benslama A
- Beraldo DO
- Berghe C
- Berkelmans F
- Besset SL
- Bettini LR
- Beuret P
- Bezzi MG
- Bhardwaj VK
- Bhowmick K
- Biehler J
- Bigot C
- Bihari S
- Biondi RS
- Biscione RR
- Bisso MC
- Black CS
- Blakeman TC
- Blanco J
- Bolon S
- Borello SA
- Borotto EE
- Botteri M
- Bouchoucha S
- Boukhazna M
- Bouw MJ
- Boyd O
- Bramall J
- Braschi A
- Brazzi L
- Breen DM
- Briquet A
- Brito VA
- Brizuela M
- Brochard L
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- Broman LM
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- Browne TS
- Bruhn AR
- Brunettini B
- Bruns MM
- Buensuseso JA
- Bugedo G
- Buise MP
- Bulpa PA
- Bumbasierevic V
- Bumbasirevic V
- Burtenshaw AJ
- Burtin P
- Buzancais G
- Béduneau G
- Camsooksai J
- Canestrini S
- Cani A
- Carbayo-Gorriz C
- Cardonnet LP
- Careless JP
- Carpentier D
- Carreño NG
- Carteaux G
- Casalena P
- Casement J
- Castro AG
- Castro S
- Catorze NT
- Cazorla-Barranquero FG
- Ceniceros-Barros A
- Cereijo E
- Cerny V
- Cerrato VI
- Cesar PS
- Ceunen H
- Ceylan I
- Chabanne R
- Chapman R
- Chau SK
- Chelly J
- Chen K
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- Chiche JD
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- Christiansen A
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- Cinnella G
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- Zogheib EH
- Ñamendys-Silva SA
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- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/01/2019
- Field of study
OBJECTIVES: To describe the characteristics and outcomes of patients with acute respiratory distress syndrome with or without spontaneous breathing and to investigate whether the effects of spontaneous breathing on outcome depend on acute respiratory distress syndrome severity. DESIGN: Planned secondary analysis of a prospective, observational, multicentre cohort study. SETTING: International sample of 459 ICUs from 50 countries. PATIENTS: Patients with acute respiratory distress syndrome and at least 2 days of invasive mechanical ventilation and available data for the mode of mechanical ventilation and respiratory rate for the 2 first days. INTERVENTIONS: Analysis of patients with and without spontaneous breathing, defined by the mode of mechanical ventilation and by actual respiratory rate compared with set respiratory rate during the first 48 hours of mechanical ventilation. MEASUREMENTS AND MAIN RESULTS: Spontaneous breathing was present in 67% of patients with mild acute respiratory distress syndrome, 58% of patients with moderate acute respiratory distress syndrome, and 46% of patients with severe acute respiratory distress syndrome. Patients with spontaneous breathing were older and had lower acute respiratory distress syndrome severity, Sequential Organ Failure Assessment scores, ICU and hospital mortality, and were less likely to be diagnosed with acute respiratory distress syndrome by clinicians. In adjusted analysis, spontaneous breathing during the first 2 days was not associated with an effect on ICU or hospital mortality (33% vs 37%; odds ratio, 1.18 [0.92-1.51]; p = 0.19 and 37% vs 41%; odds ratio, 1.18 [0.93-1.50]; p = 0.196, respectively ). Spontaneous breathing was associated with increased ventilator-free days (13 [0-22] vs 8 [0-20]; p = 0.014) and shorter duration of ICU stay (11 [6-20] vs 12 [7-22]; p = 0.04). CONCLUSIONS: Spontaneous breathing is common in patients with acute respiratory distress syndrome during the first 48 hours of mechanical ventilation. Spontaneous breathing is not associated with worse outcomes and may hasten liberation from the ventilator and from ICU. Although these results support the use of spontaneous breathing in patients with acute respiratory distress syndrome independent of acute respiratory distress syndrome severity, the use of controlled ventilation indicates a bias toward use in patients with higher disease severity. In addition, because the lack of reliable data on inspiratory effort in our study, prospective studies incorporating the magnitude of inspiratory effort and adjusting for all potential severity confounders are required
Multi-messenger observations of a binary neutron star merger
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- Zhang Y
- Zhang Y
- Zhang Y
- Zhang Y-H
- Zhang YF
- Zhang YJ
- Zhang Z
- Zhang ZL
- Zhao C
- Zhao HS
- Zhao JL
- Zhao W
- Zhao XF
- Zheng SJ
- Zhou H
- Zhou J
- Zhou M
- Zhou Z
- Zhu SJ
- Zhu XJ
- Zhu Y
- Zhu YX
- Zhu Z
- Ziegler A
- Zimmerman AB
- Zimmermann B
- Zimnukhov DS
- Ziolkowski M
- Zoll M
- Zong Z
- Zorn J
- Zornoza JD
- Zou CL
- Zuccarello F
- Zucker ME
- Zuniga J
- Zweizig J
- Zywucka N
- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2017
- Field of study
On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transient’s position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta
Identifying associations between diabetes and acute respiratory distress syndrome in patients with acute hypoxemic respiratory failure: an analysis of the LUNG SAFE database
- Author
- Abad Rd
- Abe T
- Abroug F
- Adams Jc
- Adamsson Ro
- Adolfsson A
- Aguilar Rz
- Aguirre Js
- Aguirre-Bermeo H
- Aisa Tm
- Aisiku I
- Ajetunmobi Oo
- Aker M
- Akyol Oo
- Al Dorzi Hm
- Al Jabbary As
- Albaiceta Gm
- Albarrak Mm
- Albiero D
- Alda Rs
- Alejandro Rv
- Alexander P
- Algaba Á
- Aliaga Fa
- Alisasis Au
- Allan Rm
- Allue Rm
- Almekhlafi G
- Alonso Jg
- Altaf W
- Alvarez Am
- Alvarez J
- Amin P
- Amir F
- Amor M
- An Y
- Andersen Fh
- Andoh K
- Andruszkiewicz P
- Aneman A
- Antonelli Mm
- Antônio Acp
- Aoki N
- Appelberg H
- Arabi Y
- Arabi Ym
- Arabi Ym
- Araujo Am
- Arizmendi A
- Arnal Jm
- Artiga Mjd
- Artigas A
- Ascoli A
- Au Sm
- Avila Le
- Azad R
- Azevedo Lc
- Baboi L
- Badie Jc
- Bailey Im
- Bailey Mb
- Bajwa E
- Balkhi H
- Baltus T
- Banner-Goodspeed Vm
- Barberet G
- Baron Rm
- Baronia Ak
- Barratt-Due A
- Barros Fm
- Barros Nc
- Batra H
- Battle Ce
- Bauer Pr
- Beck E
- Beck O
- Bedreag Oh
- Beegle Sh
- Beitler Jr
- Bellani G
- Bellani Giacomo
- Beloncle F
- Benslama A
- Beraldo Do
- Berkelmans F
- Besset Sl
- Bettini Lr
- Beuret P
- Bezzi Mg
- Bhardwaj Vk
- Bhowmick K
- Biehler J
- Bihari S
- Biondi Rs
- Biscione Rr
- Bisso Mc
- Black Cs
- Blakeman Tc
- Blanco J
- Bolon S
- Borello Sa
- Borotto Ee
- Botteri M
- Bouchoucha S
- Boukhazna M
- Bouw Mj
- Boyd O
- Boyle Andrew J.
- Bramall J
- Braschi A
- Braschi A
- Brazzi L
- Breen Dm
- Briquet A
- Brito Va
- Brizuela M
- Broman Lm
- Brown Sm
- Browne Ts
- Bruhn Scar
- Brunettini B
- Bruns Mm
- Buensuseso Ja
- Bugedo G
- Buise Mp
- Bulpa Pa
- Bumbasierevic V
- Bumbasirevic V
- Burtenshaw Aj
- Burtin P
- Buzancais G
- Béduneau G
- Camsooksai J
- Cani A
- Carbayo-Gorriz C
- Cardonnet Lp
- Careless Jp
- Carpentier D
- Carreño Ng
- Carteaux G
- Casalena P
- Casement J
- Castro Ag
- Castro S
- Catorze Nt
- Cazorla-Barranquero Fg
- Ceniceros-Barros A
- Cereijo E
- Cerny V
- Cerrato Vi
- Cervantes Mr
- Cesar Ps
- Ceunen H
- Ceylan I
- Chabanne R
- Chapman R
- Chau Sk
- Chelly J
- Chen K
- Chena A
- Cheng Mp
- Chiche Jd
- Chouchene I
- Choudry S
- Christiansen A
- Cimic N
- Cinnella G
- Cirone R
- Citalán Je
- Claraco-Vega Lm
- Clarkson K
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- Cohen Je
- Cole Jm
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- Colombo R
- Combaux Dm
- Combes A
- Constantin Jm
- Conti S
- Cooper R
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- Corneci De
- Cortegiani A
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- Coxo Cm
- Cracchiolo An
- Cranshaw Jh
- Crapelli G
- Crouch Dr
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- Crova Pj
- Csabi P
- Curley G
- Curto Eg
- Daldin J
- Dangers L
- Daniel F.
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- Daviaud F
- Davies Kg
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- De Haro C
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- Dector D
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- Deicas A
- Del Carmen Lorente M
- Dellamonica J
- Dellera C
- Delsing A
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- Demoule A
- Dempsey G
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- Depuydt P
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- Tainter C
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- Vascotto Er
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- Veljovic M.
- Venti A
- Vercueil A
- Vermassen J
- Verstraete R
- Villagomez A
- Villagomez Aj
- Villamagua Bg
- Villar V
- Virgilio Cg
- Vitale Mn
- Volta Ca
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- Zani G
- Zantua Ks
- Zazu A
- Zeggwagh Aa
- Zeggwagh Aa
- Zein So
- Zender Ho
- Zhai Z
- Zhang F
- Zhang Xy
- Zhao H
- Zhao J
- Zhao Xy
- Zheng R
- Zhou Fc
- Zhou S
- Zhu Bh
- Zhu Wh
- Zogheib Eh
- Ñamendys-Silva Sa
- Ünal N
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
Background: Diabetes mellitus is a common co-existing disease in the critically ill. Diabetes mellitus may reduce the risk of acute respiratory distress syndrome (ARDS), but data from previous studies are conflicting. The objective of this study was to evaluate associations between pre-existing diabetes mellitus and ARDS in critically ill patients with acute hypoxemic respiratory failure (AHRF). Methods: An ancillary analysis of a global, multi-centre prospective observational study (LUNG SAFE) was undertaken. LUNG SAFE evaluated all patients admitted to an intensive care unit (ICU) over a 4-week period, that required mechanical ventilation and met AHRF criteria. Patients who had their AHRF fully explained by cardiac failure were excluded. Important clinical characteristics were included in a stepwise selection approach (forward and backward selection combined with a significance level of 0.05) to identify a set of independent variables associated with having ARDS at any time, developing ARDS (defined as ARDS occurring after day 2 from meeting AHRF criteria) and with hospital mortality. Furthermore, propensity score analysis was undertaken to account for the differences in baseline characteristics between patients with and without diabetes mellitus, and the association between diabetes mellitus and outcomes of interest was assessed on matched samples. Results: Of the 4107 patients with AHRF included in this study, 3022 (73.6%) patients fulfilled ARDS criteria at admission or developed ARDS during their ICU stay. Diabetes mellitus was a pre-existing co-morbidity in 913 patients (22.2% of patients with AHRF). In multivariable analysis, there was no association between diabetes mellitus and having ARDS (OR 0.93 (0.78-1.11); p = 0.39), developing ARDS late (OR 0.79 (0.54-1.15); p = 0.22), or hospital mortality in patients with ARDS (1.15 (0.93-1.42); p = 0.19). In a matched sample of patients, there was no association between diabetes mellitus and outcomes of interest. Conclusions: In a large, global observational study of patients with AHRF, no association was found between diabetes mellitus and having ARDS, developing ARDS, or outcomes from ARDS. Trial registration: NCT02010073. Registered on 12 December 2013
Epidemiology and patterns of tracheostomy practice in patients with acute respiratory distress syndrome in ICUs across 50 countries
- Author
- Abad RD
- Abe T
- Abe T.
- Abroug F
- Adams JC
- Adamsson RO
- Adolfsson A
- Aguilar RZ
- Aguirre JS
- Aguirre-Bermeo H
- Aisa TM
- Aisiku I
- Ajetunmobi OO
- Aker M
- Akyol OO
- Al Dorzi HM
- Al Jabbary AS
- Albaiceta GM
- Albarrak MM
- Albiero D
- Alda RS
- Alejandro RV
- Alexander P
- Algaba Á
- Aliaga FA
- Alisasis AU
- Allan RM
- Allue RM
- Almekhlafi G
- Alonso JG
- Altaf W
- Alvarez AM
- Alvarez J
- Amin P
- Amir F
- Amor M
- An Y
- Andersen FH
- Andoh K
- Andruszkiewicz P
- Aneman A
- Antonelli MM
- Antônio ACP
- Aoki N
- Appelberg H
- Arabi Y
- Arabi YM
- Arabim YM
- Araujo AM
- Arizmendi A
- Arnal JM
- Artiga MJD
- Artigas A
- Ascoli A
- Au SM
- Avila LE
- Azad R
- Azevedo LC
- Baboi L
- Badie JC
- Bailey IM
- Bailey MB
- Bajwa E
- Balkhi H
- Baltus T
- Banner-Goodspeed VM
- Barberet G
- Baron RM
- Baronia AK
- Barratt-Due A
- Barros FM
- Barros NC
- Batra H
- Battle CE
- Bauer PR
- Beck E
- Beck O
- Bedreag OH
- Beegle SH
- Beitler JR
- Bellani G
- Bellani G.
- Beloncle F
- Benslama A
- Beraldo DO
- Berghe C
- Berkelmans F
- Besset SL
- Bettini LR
- Beuret P
- Bezzi MG
- Bhardwaj VK
- Bhowmick K
- Biehler J
- Bigot C
- Bihari S
- Biondi RS
- Biscione RR
- Bisso MC
- Black CS
- Blakeman TC
- Blanco J
- Bolon S
- Borello SA
- Borotto EE
- Botteri M
- Bouchoucha S
- Boukhazna M
- Bouw MJ
- Boyd O
- Bramall J
- Braschi A
- Brazzi L
- Breen DM
- Briquet A
- Brito VA
- Brizuela M
- Brochard L
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- Zogheib EH
- Ñamendys-Silva SA
- Ünal N
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
Background: To better understand the epidemiology and patterns of tracheostomy practice for patients with acute respiratory distress syndrome (ARDS), we investigated the current usage of tracheostomy in patients with ARDS recruited into the Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG-SAFE) study. Methods: This is a secondary analysis of LUNG-SAFE, an international, multicenter, prospective cohort study of patients receiving invasive or noninvasive ventilation in 50 countries spanning 5 continents. The study was carried out over 4 weeks consecutively in the winter of 2014, and 459 ICUs participated. We evaluated the clinical characteristics, management and outcomes of patients that received tracheostomy, in the cohort of patients that developed ARDS on day 1-2 of acute hypoxemic respiratory failure, and in a subsequent propensity-matched cohort. Results: Of the 2377 patients with ARDS that fulfilled the inclusion criteria, 309 (13.0%) underwent tracheostomy during their ICU stay. Patients from high-income European countries (n = 198/1263) more frequently underwent tracheostomy compared to patients from non-European high-income countries (n = 63/649) or patients from middle-income countries (n = 48/465). Only 86/309 (27.8%) underwent tracheostomy on or before day 7, while the median timing of tracheostomy was 14 (Q1-Q3, 7-21) days after onset of ARDS. In the subsample matched by propensity score, ICU and hospital stay were longer in patients with tracheostomy. While patients with tracheostomy had the highest survival probability, there was no difference in 60-day or 90-day mortality in either the patient subgroup that survived for at least 5 days in ICU, or in the propensity-matched subsample. Conclusions: Most patients that receive tracheostomy do so after the first week of critical illness. Tracheostomy may prolong patient survival but does not reduce 60-day or 90-day mortality. Trial registration: ClinicalTrials.gov, NCT02010073. Registered on 12 December 2013
Dark matter interpretations of ATLAS searches for the electroweak production of supersymmetric particles in s√=8 s=8 TeV proton-proton collisions
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- A Salam
- A. A. Affolder
- A. A. Alshehri
- A. A. E. Bannoura
- A. A. Elliot
- A. A. Grillo
- A. A. J. Lesage
- A. A. Komar
- A. A. Korol
- A. A. Maier
- A. A. Minaenko
- A. A. Nepomuceno
- A. A. O’Rourke
- A. A. Snesarev
- A. A. Solodkov
- A. A. Talyshev
- A. Aloisio
- A. Alonso
- A. Amorim
- A. Andreazza
- A. Angerami
- A. Annovi
- A. Antonov
- A. Artamonov
- A. Ashkenazi
- A. B. Fenyuk
- A. B. Kowalewska
- A. Baroncelli
- A. Basalaev
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- A. Beddall
- A. Bellerive
- A. Bethani
- A. Bingul
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- A. Bocci
- A. Borisov
- A. Boveia
- A. Brandt
- A. Bruni
- A. Buzatu
- A. C. Daniells
- A. C. König
- A. C. Martyniuk
- A. C. Schaffer
- A. C. Taylor
- A. Calandri
- A. Camplani
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- A. Castelli
- A. Catinaccio
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- Y. Heng
- Y. Hernández Jiménez
- Y. Horii
- Y. Huang
- Y. Ikegami
- Y. Ilchenko
- Y. Jiang
- Y. K. Kim
- Y. Kataoka
- Y. Komori
- Y. Kulchitsky
- Y. L. Chan
- Y. L. Liu
- Y. Li
- Y. Liu
- Y. Ma
- Y. Makida
- Y. Minami
- Y. Minegishi
- Y. Ming
- Y. Nagasaka
- Y. Nakahama
- Y. Ninomiya
- Y. Okumura
- Y. Oren
- Y. Qin
- Y. Rodina
- Y. Rozen
- Y. S. Gao
- Y. Sakurai
- Y. Smirnov
- Y. Sugaya
- Y. Takubo
- Y. Tayalati
- Y. Tu
- Y. Unno
- Y. Wu
- Y. Yamaguchi
- Y. Yamazaki
- Y. Yang
- Y. Yasu
- Y. Zhao
- Y. Zhu
- Yu. A. Tikhonov
- Z. Barnovska-Blenessy
- Z. D. Greenwood
- Z. Dolezal
- Z. Gecse
- Z. H. Citron
- Z. Hajduk
- Z. Hubacek
- Z. Idrissi
- Z. J. Grout
- Z. Liang
- Z. M. Karpova
- Z. Marshall
- Z. Rurikova
- Z. Vykydal
- Z. Yan
- Z. Yang
- Z. Zhang
- Z. Zhao
- Z. Zinonos
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
A selection of searches by the ATLAS experiment at the LHC for the electroweak production of SUSY particles are used to study their impact on the constraints on dark matter candidates. The searches use 20 fb−1 of proton-proton collision data at s √ =8 s=8 TeV. A likelihood-driven scan of a five-dimensional effective model focusing on the gaugino-higgsino and Higgs sector of the phenomenological minimal supersymmetric Standard Model is performed. This scan uses data from direct dark matter detection experiments, the relic dark matter density and precision flavour physics results. Further constraints from the ATLAS Higgs mass measurement and SUSY searches at LEP are also applied. A subset of models selected from this scan are used to assess the impact of the selected ATLAS searches in this five-dimensional parameter space. These ATLAS searches substantially impact those models for which the mass m(χ ~ 0 1 ) m(χ~10) of the lightest neutralino is less than 65 GeV, excluding 86% of such models. The searches have limited impact on models with larger m(χ ~ 0 1 ) m(χ~10) due to either heavy electroweakinos or compressed mass spectra where the mass splittings between the produced particles and the lightest supersymmetric particle is small
First measurement of the |t|-dependence of coherent J/ψ photonuclear production
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- Willems GA
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- Witt WE
- Xu R
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- Yin Z
- Yokoyama H
- Yoo I-K
- Yoon JH
- Yuan S
- Yurchenko V
- Zaccolo V
- Zaman A
- Zampolli C
- Zanoli HJC
- Zardoshti N
- Zarochentsev A
- Zavada P
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- Zbroszczyk H
- Zhalov M
- Zhang X
- Zhang Y
- Zhang Z
- Zhao C
- Zherebchevskii V
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- Zhou Z
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- Zhu Y
- Zichichi A
- Zimmermann MB
- Zinovjev G
- Zmeskal J
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
The first measurement of the cross section for coherent J/ψ photoproduction as a function of |t|, the square of the momentum transferred between the incoming and outgoing target nucleus, is presented. The data were measured with the ALICE detector in ultra-peripheral Pb–Pb collisions at a centre-of-mass energy per nucleon pair sNN=5.02TeV with the J/ψ produced in the central rapidity region |y|<0.8, which corresponds to the small Bjorken-x range (0.3−1.4)×10−3.
The measured |t|-dependence is not described by computations based only on the Pb nuclear form factor, while the photonuclear cross section is better reproduced by models including shadowing according to the leading-twist approximation, or gluon-saturation effects from the impact-parameter dependent Balitsky–Kovchegov equation. These new results are therefore a valid tool to constrain the relevant model parameters and to investigate the transverse gluonic structure at very low Bjorken-x.publishedVersio
Comparative transcriptome analysis reveals different strategies for degradation of steam-exploded sugarcane bagasse by Aspergillus niger and Trichoderma reesei
- Author
- A Amore
- A Bourdais
- A Criscuolo
- A Levasseur
- A Saloheimo
- A Schuster
- A Sethi
- Aline Tieppo de Souza
- Angélica de Oliveira Pontes
- AR Stricker
- AR Stricker
- B Zhang
- BE Della-Bianca
- BG Jensen
- BM Nitsche
- BR Scott
- BS Gruben
- BS Gruben
- C Derntl
- C Florencio
- C Ivanova
- Camila Cristina Sanchez
- CE Dowzer
- CL Dos Santos
- CL Santos dos
- CP Kubicek
- D Glassop
- D Kim
- D Klein-Marcuschamer
- D Kracher
- D Poggi-Parodi
- D Verma
- DG Hatzinikolaou
- Diego Mauricio Riaño-Pachón
- E Battaglia
- E Fernandez-Fueyo
- E Kunitake
- E Kunitake
- EL Sonnhammer
- Eliane Silva de Santana
- EM Young
- ES Martens-Uzunova
- F Lu
- F Segato
- GC Cerqueira
- GJ Ruijter
- GL Miller
- GM Rashid
- GP Borin
- GR Hemsworth
- Guilherme Keppe Zanini
- Gustavo Henrique Goldman
- Gustavo Pagotto Borin
- H Nordberg
- HJ Pel
- HV Amorim
- I Benoit
- J Bayry
- J Carro
- J Karlsson
- J Kuuskeri
- J Popp
- J Sloothaak
- J Strauss
- J Zhang
- JE Kowalczyk
- JE Kowalczyk
- JH Clark
- JM Munster van
- JP Franco Cairo
- Juliana Velasco de Castro Oliveira
- K Bohle
- K Suzuki
- KE Hammel
- KK Nakasone
- KR Frederick
- L Kappel
- L Lehmann
- L Li
- L Ries
- L Wang
- M Eibinger
- M Hakkinen
- M Hakkinen
- M Ilmen
- M Mandels
- M Nitta
- M Ogawa
- M Prieto
- M Saloheimo
- M Schmoll
- M Schmoll
- M Tanghe
- MA Esawy
- MC Wanderley
- MD Robinson
- MG Steiger
- MR Andersen
- MR Drysdale
- N Aro
- N Aro
- N Aro
- N Jacquet
- NA Brown
- NN Peij van
- NRAF Rocha
- P Perez-Rodriguez
- P Rasoulnia
- PA Kuyk van
- PK Foreman
- PR Kommoju
- PW Dijck van
- R Bischof
- R He
- R Peterson
- RA Lockington
- RC Correa
- RCC Leite
- Renato Augusto Corrêa dos Santos
- Roberta Maria Menegaldo Tavares Soa Dal’Mas
- RP Vries de
- RR Singhania
- S Crom Le
- S Delmas
- S Mitidieri
- S Mohanram
- S Tarazona
- S Zeilinger
- S Zhao
- SC Rabelo
- SE Baker
- SR Patil
- ST Pullan
- TN Petersen
- TR Jorgensen
- V Lombard
- V Seidl
- W Kricka
- W Zhang
- WR Souza de
- WR Souza de
- X Wang
- XL Yuan
- Y Liao
- Y Mathieu
- Y Yin
- ZB Huang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
- …