1,476 research outputs found
Goldstone Bosons in Effective Theories with Spontaneously Broken Flavour Symmetry
- Author
- AJ Buras
- AJ Buras
- AL Kagan
- B Stech
- B Zumino
- C Cheung
- CD Froggatt
- F Wilczek
- F Wilczek
- G D’Ambrosio
- GL Kane
- J Berger
- J Preskill
- J Wess
- JE Kim
- M Antonelli
- M Artuso
- M Ciuchini
- M Leurer
- M Leurer
- M-C Chen
- M. E. Albrecht
- MA Shifman
- P Fileviez Perez
- P Langacker
- PH Frampton
- Q Chang
- Q Chang
- R Barbieri
- R Barbieri
- R Barbieri
- R Mohanta
- R Zwicky
- RD Peccei
- RD Peccei
- RD Peccei
- S Antusch
- S Weinberg
- SF King
- T Feldmann
- T Feldmann
- T Feldmann
- TE Browder
- Th. Feldmann
- Th. Mannel
- V Barger
- V Barger
- V Cirigliano
- WA Bardeen
- Z Berezhiani
- ZG Berezhiani
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 03/09/2010
- Field of study
The Flavour Symmetry of the Standard Model (SM) gauge sector is broken by the
fermion Yukawa couplings. Promoting the Yukawa matrices to scalar spurion
fields, one can break the flavour symmetry spontaneously by giving appropriate
vacuum expectation values (VEVs) to the spurion fields, and one encounters
Goldstone modes for every broken flavour symmetry generator. In this paper, we
point out various aspects related to the possible dynamical interpretation of
the Goldstone bosons: (i) In an effective-theory framework with local flavour
symmetry, the Goldstone fields represent the longitudinal modes for massive
gauge bosons. The spectrum of the latter follows the sequence of
flavour-symmetry breaking related to the hierarchies in Yukawa couplings and
flavour mixing angles. (ii) Gauge anomalies can be consistently treated by
adding higher-dimensional operators. (iii) Leaving the U(1) factors of the
flavour symmetry group as global symmetries, the respective Goldstone modes
behave as axions which can be used to resolve the strong CP problem by a
modified Peccei-Quinn mechanism. (iv) The dynamical picture of flavour symmetry
breaking implies new sources of flavour-changing neutral currents, which arise
from integrating out heavy scalar spurion fields and heavy gauge bosons. The
coefficients of the effective operators follow the minimal-flavour violation
principle.Comment: 27 pages, abstract and introduction extended, more detailed
discussion of heavy gauge boson spectrum and auxiliary heavy fermions,
outline restructured. Matches version to be published in JHE
Search for rare quark-annihilation decays, B --> Ds(*) Phi
- Author
- Abe T
- Abrams GS
- Adye T
- Ahmed M
- Ahmed S
- Alam MS
- Albert J
- Aleksan R
- Allen MT
- Allison J
- Allmendinger T
- Altenburg D
- Andreassen R
- Andreotti M
- Angelini C
- Anulli F
- Arnaud N
- Aston D
- Aubert B
- Azzolini V
- Baak M
- Back JJ
- Baldini-Ferroli R
- Band HR
- Banerjee S
- Barate R
- Bard DJ
- Barlow NR
- Barlow RJ
- Barrett M
- Bartoldus R
- Batignani G
- Battaglia M
- Bauer JM
- Beck TW
- Behera PK
- Bellini F
- Benayoun M
- Benelli G
- Berger N
- Bernard D
- Berryhill JW
- Best D
- Bettarini S
- Bettoni D
- Bevan AJ
- Bhimji W
- Bhuyan B
- Bianchi F
- Biasini M
- Biesiada J
- Blanc F
- Blaylock G
- Blinov AE
- Blinov VE
- Bloom PC
- Blount NL
- Bomben M
- Bona M
- Bondioli M
- Bonneaud GR
- Bosisio L
- Boutigny D
- Bowerman DA
- Boyarski AM
- Boyd JT
- Bozzi C
- Brandenburg G
- Brandt T
- Brau J
- Breon AB
- Brose J
- Brown CL
- Brown CM
- Brown DN
- Brown DN
- Bruinsma M
- Brunet S
- Bucci F
- Buchanan C
- Buchmueller OL
- Bugg W
- Bukin AD
- Bula R
- Bulten H
- Buono LD
- Burchat PR
- Burke JP
- Button-Shafer J
- Buzzo A
- Cahn RN
- Calabrese R
- Calcaterra A
- Calderini G
- Campagnari C
- Capra R
- Carpinelli M
- Cartaro C
- Cavallo N
- Cavoto G
- Cenci R
- Chai X
- Chaisanguanthum KS
- Chao M
- Charles E
- Charles MJ
- Chauveau J
- Chavez CA
- Chen A
- Chen C
- Chen E
- Chen JC
- Chen S
- Chen X
- Cheng B
- Cheng CH
- Chia YM
- Cibinetto G
- Clark PJ
- Claus R
- Cochran J
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- Collaboration BABAR
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- Convery MR
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- Cote D
- Cottingham WN
- Couderc F
- Covarelli R
- Cowan G
- Cowan R
- Crawley HB
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- Cristinziani M
- Cuhadar-Donszelmann T
- Cunha A
- Curry S
- D'Orazio A
- Dahmes B
- Dallapiccola C
- Danielson N
- Dasu S
- Datta M
- Dauncey PD
- David P
- Davier M
- Davis CL
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- de la Vaissiere C
- de Monchenault GH
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- Dickopp M
- Dingfelder JC
- Dittongo S
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- Dorfan J
- Druzhinin VP
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- Eckhart EA
- Eckmann R
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- Ernst JA
- Eschenburg V
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- Eyges V
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- Groysman Y
- Guo QH
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- Hart AJ
- Hartfiel BL
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- Hill EJ
- Hirschauer JF
- Hitlin DG
- Hocker A
- Hodgkinson MC
- Hollar JJ
- Hong TM
- Honscheid K
- Hopkins DA
- Hryn'ova T
- Hufnagel D
- Hulsbergen WD
- Hutchcroft DE
- Igonkina O
- Innes WR
- Izen JM
- Jackson PD
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- Jacobsen RG
- Jawahery A
- Jessop CP
- John MJJ
- Johnson JR
- Judd D
- Kadel RW
- Kadyk J
- Kagan H
- Karyotakis Y
- Kass R
- Kelly MP
- Kelsey MH
- Kerth LT
- Khan A
- Kim H
- Kim P
- Kirkby D
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- Kolomensky YG
- Kovalskyi D
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- Kozanecki W
- Kravchenko EA
- Kreisel A
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- Kroeger R
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- Kyberd P
- Lacker HM
- Lae CK
- Lafferty GD
- Lanceri L
- Lange DJ
- Langenegger U
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- Latham TE
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- Lau YP
- Lazzaro A
- Lees JP
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- Leith DWGS
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- Lewandowski B
- Li H
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- Long O
- LoSecco JM
- Lou XC
- Lu C
- Lu M
- Luitz S
- Lund P
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- Luth V
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- Lynch G
- Lynch HL
- MacFarlane DB
- Macri MM
- Mader WF
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- Mallik U
- Mancinelli G
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- Marchiori G
- Marco ED
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- Mattison TS
- Mayer B
- Mazur MA
- Mazzoni MA
- McKenna JA
- McMahon TR
- Meadows BT
- Mellado B
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- Messner R
- Meyer WT
- Mihalyi A
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- Mir LM
- Mohanty GB
- Mohapatra AK
- Mommsen RK
- Monge MR
- Monorchio D
- Moore TB
- Morandin M
- Morgan SE
- Morganti M
- Morganti S
- Morii M
- Muheim F
- Muller DR
- Naisbit MT
- Nardo GD
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- Nash JA
- Nauenberg U
- Neal H
- Negrini M
- Neri N
- Nesom G
- Nicholson H
- Nikolich MB
- Nogowski R
- Nugent IM
- O'Grady CP
- Ocariz J
- Oddone PJ
- Ofte I
- Olaiya EO
- Olivas A
- Olsen J
- Onuchin AP
- Orimoto TJ
- Otto S
- Oyanguren A
- Ozcan VE
- Paar HP
- Pacetti S
- Palano A
- Palombo F
- Pan Y
- Panetta J
- Panvini RS
- Paoloni E
- Paolucci P
- Pappagallo M
- Parry RJ
- Passaggio S
- Patel PM
- Patrignani C
- Patteri P
- Payne DJ
- Pelizaeus M
- Perazzo A
- Perl M
- Peruzzi IM
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- Petersen BA
- Petersen TC
- Petzold A
- Piatenko T
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- Rosenberg EI
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- Schwitters RF
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- Sinev NB
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- Stelzer J
- Stocchi A
- Stoker DP
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- Sundermann JE
- Suzuki K
- Swain SK
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- Taylor F
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- Telnov AV
- Teodorescu L
- Ter-Antonyan R
- Therin G
- Thiebaux C
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- Tisserand V
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- Ulmer KA
- Uwer U
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- van Bakel N
- Vasileiadis G
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- Verkerke W
- Vetere ML
- Viaud FB
- Vitale L
- Voci C
- Voena C
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- Wagoner DE
- Waldi R
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- Wang P
- Wang WF
- Wappler FR
- Watson AT
- Weaver M
- Weidemann AW
- Weinstein AJR
- Wenzel WA
- Wilden L
- Williams DC
- Williams JC
- Willocq SY
- Wilson FF
- Wilson JR
- Wilson MG
- Wilson RJ
- Winklmeier F
- Wisniewski WJ
- Wittgen M
- Wong QK
- Wormser G
- Wright DH
- Wright DM
- Wu J
- Wu SL
- Xie Y
- Yamamoto RK
- Yarritu AK
- Ye S
- Yeche C
- Yi JI
- Yi K
- Young CC
- Yu Z
- Yushkov AN
- Zain SB
- Zallo A
- Zeng Q
- Zghiche A
- Zhang J
- Zhang L
- Zhao HW
- Zhu YS
- Ziegler V
- Zito M
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 12/12/2005
- Field of study
We report on searches for B- --> Ds- Phi and B- --> Ds*- Phi. In the context
of the Standard Model, these decays are expected to be highly suppressed since
they proceed through annihilation of the b and u-bar quarks in the B- meson.
Our results are based on 234 million Upsilon(4S) --> B Bbar decays collected
with the BABAR detector at SLAC. We find no evidence for these decays, and we
set Bayesian 90% confidence level upper limits on the branching fractions BF(B-
--> Ds- Phi) Ds*- Phi)<1.2x10^(-5). These results
are consistent with Standard Model expectations.Comment: 8 pages, 3 postscript figues, submitted to Phys. Rev. D (Rapid
Communications
Measurement of the inclusive and dijet cross-sections of b-jets in pp collisions at sqrt(s) = 7 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdesselam A
- Abdinov O
- Abi B
- Abolins M
- Abramowicz H
- Abreu H
- Acerbi E
- Acharya BS
- Ackers M
- Adams DL
- Addy TN
- Adelman J
- Aderholz M
- Adomeit S
- Adragna P
- Adye T
- Aefsky S
- Aguilar-Saavedra JA
- Aharrouche M
- Ahlen SP
- Ahles F
- Ahmad A
- Ahsan M
- Aielli G
- Akdogan T
- Akesson TPA
- Akimoto G
- Akimov AV
- Alam MA
- Alam MS
- Albrand S
- Aleksa M
- Aleksandrov IN
- Aleppo M
- Alessandria F
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Aliev M
- Alimonti G
- Alison J
- Aliyev M
- Allport PP
- Allwood-Spiers SE
- Almenar CC
- Almond J
- Aloisio A
- Alon R
- Alonso A
- Alonso J
- Alviggi MG
- Amako K
- Amaral P
- Amelung C
- Ammosov VV
- Amorim A
- Amoros G
- Amram N
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- Anderson KJ
- Andreazza A
- Andrei V
- Andrieux M-L
- Anduaga XS
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- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 31/12/2010
- Field of study
The inclusive and dijet production cross-sections have been measured for jets
containing b-hadrons (b-jets) in proton-proton collisions at a centre-of-mass
energy of sqrt(s) = 7 TeV, using the ATLAS detector at the LHC. The
measurements use data corresponding to an integrated luminosity of 34 pb^-1.
The b-jets are identified using either a lifetime-based method, where secondary
decay vertices of b-hadrons in jets are reconstructed using information from
the tracking detectors, or a muon-based method where the presence of a muon is
used to identify semileptonic decays of b-hadrons inside jets. The inclusive
b-jet cross-section is measured as a function of transverse momentum in the
range 20 < pT < 400 GeV and rapidity in the range |y| < 2.1. The bbbar-dijet
cross-section is measured as a function of the dijet invariant mass in the
range 110 < m_jj < 760 GeV, the azimuthal angle difference between the two jets
and the angular variable chi in two dijet mass regions. The results are
compared with next-to-leading-order QCD predictions. Good agreement is observed
between the measured cross-sections and the predictions obtained using POWHEG +
Pythia. MC@NLO + Herwig shows good agreement with the measured bbbar-dijet
cross-section. However, it does not reproduce the measured inclusive
cross-section well, particularly for central b-jets with large transverse
momenta.Comment: 10 pages plus author list (21 pages total), 8 figures, 1 table, final
version published in European Physical Journal
Search for direct pair production of the top squark in all-hadronic final states in proton-proton collisions at s√=8 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdinov O
- Aben R
- Abi B
- Abolins M
- AbouZeid OS
- Abramowicz H
- Abreu H
- Abreu R
- Abulaiti Y
- Acharya BS
- Adamczyk L
- Adams DL
- Adelman J
- Adomeit S
- Adye T
- Agatonovic-Jovin T
- Aguilar-Saavedra JA
- Agustoni M
- Ahlen SP
- Ahmadov F
- Aielli G
- Akerstedt H
- Akesson TPA
- Akimoto G
- Akimov AV
- Alberghi GL
- Albert J
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- Alconada Verzini MJ
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Alimonti G
- Alio L
- Alison J
- Allbrooke BMM
- Allison LJ
- Allport PP
- Almond J
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- Alonso F
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- Alviggi MG
- Amako K
- Amaral Coutinho Y
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- Amor Dos Santos SP
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- Zurzolo G
- Zutshi V
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
The results of a search for direct pair production of the scalar partner to the top quark using an integrated luminosity of 20.1fb−1 of proton–proton collision data at √s = 8 TeV recorded with the ATLAS detector at the LHC are reported. The top squark is assumed to decay via t˜→tχ˜01 or t˜→ bχ˜±1 →bW(∗)χ˜01 , where χ˜01 (χ˜±1 ) denotes the lightest neutralino (chargino) in supersymmetric models. The search targets a fully-hadronic final state in events with four or more jets and large missing transverse momentum. No significant excess over the Standard Model background prediction is observed, and exclusion limits are reported in terms of the top squark and neutralino masses and as a function of the branching fraction of t˜ → tχ˜01 . For a branching fraction of 100%, top squark masses in the range 270–645 GeV are excluded for χ˜01 masses below 30 GeV. For a branching fraction of 50% to either t˜ → tχ˜01 or t˜ → bχ˜±1 , and assuming the χ˜±1 mass to be twice the χ˜01 mass, top squark masses in the range 250–550 GeV are excluded for χ˜01 masses below 60 GeV
Search for pair-produced long-lived neutral particles decaying to jets in the ATLAS hadronic calorimeter in ppcollisions at √s=8TeV
- Author
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- Yen AL
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- Yildiz HD
- Yilmaz M
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- Young CJS
- Youssef S
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- Zaidan R
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- Zambito S
- Zanello L
- Zanzi D
- Zeitnitz C
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- Zemla A
- Zengel K
- Zenin O
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- Zhemchugov A
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- Zhou N
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- Zhukov K
- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann C
- Zimmermann R
- Zimmermann S
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- Zinonos Z
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- Zobernig G
- Zoccoli A
- zur Nedden M
- Zurzolo G
- Zutshi V
- Zwalinski L
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2014
- Field of study
The ATLAS detector at the Large Hadron Collider at CERN is used to search for the decay of a scalar boson to a pair of long-lived particles, neutral under the Standard Model gauge group, in 20.3fb−1of data collected in proton–proton collisions at √s=8TeV. This search is sensitive to long-lived particles that decay to Standard Model particles producing jets at the outer edge of the ATLAS electromagnetic calorimeter or inside the hadronic calorimeter. No significant excess of events is observed. Limits are reported on the product of the scalar boson production cross section times branching ratio into long-lived neutral particles as a function of the proper lifetime of the particles. Limits are reported for boson masses from 100 GeVto 900 GeV, and a long-lived neutral particle mass from 10 GeVto 150 GeV
Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at √ s = 8 TeV with the ATLAS detector
- Author
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- Abbott B
- Abbott DC
- Abeling K
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
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- Tseng JC-L
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- Tsopoulou M
- Tsukerman II
- Tsulaia V
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- Tudorache V
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- Vadla KOH
- Vaidya A
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- Valentinetti S
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- Varnes EW
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- Vukotic I
- Wagner P
- Wagner W
- Wagner-Kuhr J
- Wahdan S
- Wahlberg H
- Walbrecht VM
- Walder J
- Walker R
- Walker SD
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- Wallangen V
- Wang AM
- Wang AZ
- Wang C
- Wang F
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- Wang Q
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- Wang R-J
- Wang SM
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- Wanotayaroj C
- Warburton A
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- Washbrook A
- Watson AT
- Watson MF
- Watts G
- Waugh BM
- Webb AF
- Webb S
- Weber C
- Weber MS
- Weber SA
- Weber SM
- Weidberg AR
- Weingarten J
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- Weiser C
- Wells PS
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- Wengler T
- Wenig S
- Wermes N
- Werner MD
- Wessels M
- Weston TD
- Whalen K
- Whallon NL
- Wharton AM
- White A
- White AS
- White MJ
- Whiteson D
- Whitmore BW
- Wiedenmann W
- Wiel C
- Wielers M
- Wieseotte N
- Wiglesworth C
- Wiik-Fuchs LAM
- Wilkens HG
- Wilkins LJ
- Williams HH
- Williams S
- Willis C
- Willocq S
- Wingerter-Seez I
- Winkels E
- Winklmeier F
- Winston OJ
- Winter BT
- Wittgen M
- Wobisch M
- Wolf A
- Wolf TMH
- Wolff R
- Wolker R
- Wollrath J
- Wolter MW
- Wolters H
- Wong VWS
- Woods NL
- Worm SD
- Wosiek BK
- Wozniak KW
- Wraight K
- Wu SL
- Wu X
- Wu Y
- Wyatt TR
- Wynne BM
- Xella S
- Xi Z
- Xia L
- Xiao X
- Xiotidis I
- Xu D
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- Yabsley B
- Yacoob S
- Yajima K
- Yallup DP
- Yamaguchi N
- Yamaguchi Y
- Yamamoto A
- Yamatani M
- Yamazaki T
- Yamazaki Y
- Yan Z
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- Yao W-M
- Yap YC
- Yasu Y
- Yatsenko E
- Ye H
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- Ye S
- Yeletskikh I
- Yexley MR
- Yigitbasi E
- Yildiz HD
- Yorita K
- Yoshihara K
- Young C
- Young CJS
- Yu J
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- Yue X
- Zaazoua M
- Zabinski B
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- Zaffaroni E
- Zahreddine J
- Zaitsev AM
- Zakareishvili T
- Zakharchuk N
- Zambito S
- Zanzi D
- Zaripovas DR
- Zeissner S
- Zeitnitz C
- Zemaityte G
- Zeng JC
- Zenin O
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- Zerwas D
- Zgubic M
- Zhang B
- Zhang DF
- Zhang G
- Zhang H
- Zhang J
- Zhang L
- Zhang M
- Zhang R
- Zhang S
- Zhang X
- Zhang Y
- Zhang Z
- Zhao P
- Zhao Z
- Zhemchugov A
- Zheng Z
- Zhong D
- Zhou B
- Zhou C
- Zhou M
- Zhou MS
- Zhou N
- Zhou Y
- Zhu C
- Zhu CG
- Zhu H
- Zhu HL
- Zhu J
- Zhu Y
- Zhuang X
- Zhukov K
- Zhulanov V
- Zieminska D
- Zimine N
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zivkovic L
- Zobernig G
- Zoccoli A
- Zoch K
- Zorbas TG
- Zou R
- Zu Theenhausen HM
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses 20.3 fb−1 of √ s = 8 TeV data collected in 2012 with the ATLAS detector at the LHC. Events are required to have at least one jet with pT > 120 GeV and no leptons. Nine signal regions are considered with increasing missing transverse momentum requirements between Emiss T > 150 GeV and Emiss T > 700 GeV. Good agreement is observed between the number of events in data and Standard Model expectations. The results are translated into exclusion limits on models with either large extra spatial dimensions, pair production of weakly interacting dark matter candidates, or production of very light gravitinos in a gauge-mediated supersymmetric model. In addition, limits on the production of an invisibly decaying Higgs-like boson leading to similar topologies in the final state are presente
Sex doll ownership: an agenda for research
- Author
- A Ferguson
- BB Chatterjee
- BJ Dixson
- C Cox-George
- CA MacKinnon
- CJ Ferguson
- Craig A. Harper
- D Finkelhor
- D Knox
- D Singh
- E Fosch-Villaronga
- E Orehek
- E(L) Papadaki
- EA Vasquez
- EC Carvalho Nascimento
- G Saad
- G Saad
- GCN Hall
- J Danaher
- J Danaher
- J Danaher
- J Danaher
- J Eggleton
- J Hilgard
- JD Griffith
- JM Szczuka
- K Richardson
- L Strikwerda
- M Butovskaya
- M Del Zotto
- M Langcaster-James
- M Morgan
- M-H Maras
- MB Mathur
- MC Nussbaum
- MC Seto
- N Döring
- N Döring
- N Kock
- N Shokri
- NM Malamuth
- NM Su
- P Singer
- R Eskens
- R Sparrow
- RC Seabrook
- Rebecca Lievesley
- S Brownmiller
- S Kagan
- SJ Gervais
- T Ward
- T Ward
- V Cassidy
- WA Fisher
- WD Lassek
- WL Marshall
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 15/08/2020
- Field of study
Purpose of review: The topic of sex doll ownership is becoming an increasingly discussed issue from both a social and legal perspective. This review aims to examine the veracity of the existing psychological, sexological, and legal literature in relation to doll ownership.
Recent findings: Strong views exist across the spectrum of potential socio-legal positions on sex doll ownership. However, there is an almost total lack of empirical analyses of the psychological characteristics or behavioral implications of doll ownership. As such, existing arguments appear to represent the philosophical positions of those scholars expressing them, rather than being rooted in any objective evidence base.
Summary: Despite an absence of empirical data on the characteristics and subsequent effects of doll ownership, discussions about the ethical and legal status of doll ownership continue. This highlights a real and urgent need for a coherent research agenda to be advanced in this area of work
Intensity-Modulated Radiotherapy in Patients with Cervical Cancer. An intra-individual Comparison of Prone and Supine Positioning
- Author
- A van't Riet
- Achim Schneider
- AJ Mundt
- AJ Mundt
- Carmen Stromberger
- Christhardt Köhler
- CW Whitney
- DE Heron
- EY Huang
- F Landoni
- F Siddiqui
- G Hänsgen
- HG Strauss
- HJ Andreyev
- HS Ryu
- IJ Das
- International Commision on Radiation Units and Measurements
- International Commission on Radiation Units & Measurements
- J Füller
- J Martin
- JA Green
- JC Roeske
- JF Barter
- JG Letschert
- JG Letschert
- JK Salama
- JM Kirwan
- K Gerszten
- K Ghosh
- K Vandecasteele
- L Portelance
- M Adli
- M Bouchard
- M Morris
- M Olofsen-van Acht
- M Pinkawa
- MF Chen
- MF Chen
- Michael Kawgan-Kagan
- MJ Gallagher
- P Georg
- PG Rose
- RS Ahmed
- S Beriwal
- S Beriwal
- S Marnitz
- S Marnitz
- S Marnitz
- Simone Marnitz
- Tristan Mensing
- Ulrich Jahn
- V Nagy
- Volker Budach
- WA Peters
- WD D'Souza
- Yves Kom
- Publication venue
- BioMed Central
- Publication date
- 01/01/2010
- Field of study
<p>Abstract</p> <p>Background</p> <p>Chemoradiation for cervical cancer patients is associated with considerable gastrointestinal toxicity. Intensity-modulated radiotherapy (IMRT) has demonstrated superiority in terms of target coverage and normal tissue sparing in comparison to conventional 3D planning in gynaecological malignancies. Whether IMRT in prone (PP) or supine position (SP) might be beneficial for cervical cancer patients remains partially unanswered.</p> <p>Methods</p> <p>10 patients on FIGO stage IB-III cervical cancer, 6 patients for definitive and 4 patients for adjuvant external beam pelvic RT, were planned in PP and SP using a 7-field IMRT technique. IMRT plans for PP and SP (mean dose, D<sub>mean </sub>50.4 Gy) were optimized in terms of PTV coverage (1<sup>st </sup>priority) and small bowel sparing (2<sup>nd </sup>priority). A comparison of DVH parameters for PTV, small bowel, bladder, and rectum was performed.</p> <p>Results</p> <p>The comparison showed a similar PTV coverage of 95% of the prescribed dose and for target conformity in IMRT plans (PP, SP). PTV, rectum and bladder volumes were comparable for PP and SP. Significantly larger volumes of small bowel were found in PP (436 cc, + 35%, p = 0.01). PP decreased the volume of small bowel at 20-50.4 Gy (p < 0.05) and increased the rectum volumes covered by doses from 10-40 Gy (p < 0.01), the V50.4 was < 5% in both treatment positions. Bladder sparing was significant better at 50.4 Gy (p = 0.03) for PP.</p> <p>Conclusion</p> <p>In this dosimetric study, we demonstrated that pelvic IMRT in prone position for patients with cervical cancer seems to be beneficial in reducing small bowel volume at doses ≥20 Gy while providing similar target coverage and target conformity. The use of frequent image guidance with KV (kilovolt) or MV (megavolt) computertomography can reduce set-up deviations, and treatment in prone position can be done with a higher set-up accuracy. Clinical outcome studies are needed to affirm lower toxicity.</p
Case-based learning and multiple choice questioning methods favored by students
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Supreme activity of gramicidin S against resistant, persistent and biofilm cells of staphylococci and enterococci.
- Author
- A Carotenuto
- AM Edwards
- AM Guzman Prieto
- AP Magiorakos
- B Herigstad
- C de la Fuente-Núñez
- C Pozzi
- CA Arias
- CK Tan
- CL Ventola
- CR Arciola
- D Pletzer
- D Zhang
- E Maisonneuve
- EJ Prenner
- EM Krauss
- EM Krauss
- F Jockenhöfer
- GF Gause
- H Nikaido
- HJ Chen
- I Keren
- I Wiegand
- J Kyte
- JB Kaplan
- JB Patel
- JC Cortay
- JG Hurdle
- JN Pendleton
- K Lewis
- K Valkó
- K Valkó
- L Andresen
- L Czaplewski
- L Ringstad
- L Steinstraesser
- L Zhang
- M Bagheri
- M Berditsch
- M Berditsch
- M Berditsch
- M Berditsch
- M Berditsch
- M D’Abramo
- M Galluzzi
- M Hartmann
- M Ng
- M Otto
- M Wenzel
- M Wenzel
- M Wieczorek
- M Wu
- MA Marahiel
- Marina Berditsch
- ML Mangoni
- MR Saviello
- N Sánchez de Groot
- O Babii
- PG Sergiev
- PJT Johnson
- PS Stewart
- R Domalaon
- R Serra
- R Singh
- RA Proctor
- RX Lins
- S Afonin
- S Afonin
- S Mohamadi
- S Stepanović
- SC Mansour
- SJ Yang
- T Mogi
- TK Wood
- VE Kagan
- WA McGuinness
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 29/11/2019
- Field of study
Three promising antibacterial peptides were studied with regard to their ability to inhibit the growth and kill the cells of clinical strains of Staphylococcus aureus, Enterococcus faecalis and Enterococcus faecium. The multifunctional gramicidin S (GS) was the most potent, compared to the membranotropic temporin L (TL), being more effective than the innate-defence regulator IDR-1018 (IDR). These activities, compared across 16 strains as minimal bactericidal and minimal inhibitory concentrations (MIC), are independent of bacterial resistance pattern, phenotype variations and/or biofilm-forming potency. For S. aureus strains, complete killing is accomplished by all peptides at 5 × MIC. For E. faecalis strains, only GS exhibits a rapid bactericidal effect at 5 × MIC, while TL and IDR require higher concentrations. The biofilm-preventing activities of all peptides against the six strains with the largest biofilm biomass were compared. GS demonstrates the lowest minimal biofilm inhibiting concentrations, whereas TL and IDR are consistently less effective. In mature biofilms, only GS completely kills the cells of all studied strains. We compare the physicochemical properties, membranolytic activities, model pharmacokinetics and eukaryotic toxicities of the peptides and explain the bactericidal, antipersister and antibiofilm activities of GS by its elevated stability, pronounced cell-penetration ability and effective utilization of multiple modes of antibacterial action
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